Subclinical Hypothyroidism & Metabolic Disease Michael D. Loughner, M.D. Endocrinology Associates, Denver, CO 303-722-4683 (p), 303-778-0726 (fax) May 2010
Elevated Total and LDL Cholesterol in SCH • 2108 participants from community health survey in Australia
SCH Euthyroid
Total Chol*
LDL*
(mg/dl)
(mg/dl)
244
159
224
135
* p < 0.003
No difference seen in mean HDL or triglyceride levels
Clin Endocrinol (Oxf). 2005 Dec;63(6):670-5.
Altered Lipids Across TSH Reference Range • Cross-sectional population-based study of 30,656 subjects without known thyroid disease in Norway – Demonstrated that increasing TSH levels across the reference range (0.2-4.5 mIU/L) were linearly associated with deranged lipid concentrations p 240 mg/dl
Thyroid. 2007 Nov;17(11):1075-84.
Thyroid Function Associated with Metabolic Syndrome • Roos et al.: Cross-sectional cohort study of 2703 subjects – Both free T4 and TSH significantly associated with HOMA-IR (p