Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Lung Diseases Conference
AGENDA MONDAY, JULY 27
8:30‐4:30 PM Hands‐on workshop, Rowell Building, UVM Campus 5:00‐6:00 Welcoming Reception and Registration, Hotel Vermont
Session 1:
Tracheal Bioengineering: Progress and Controversies Follow up to ISCT Scientific Signature Series Tracheal Bioengineering Session (April 2014, Paris)
Moderators:
Scott Randell, PhD ~ UNC Marsico Lung Institute/CF Center Thomas Waddell, MD, PhD ~ University of Toronto (20 minute talks followed by 10 min Q/A)
6:00‐6:30 6:30‐7:00 7:00‐7:30 7:30‐8:00 8:00‐8:30 8:30‐9:00 9:00
Featured Presentation: Clinical Application of Bioengineered Trachea and Larynx Martin Birchall, MD ~ University College London
Featured Presentation: Airway Regeneration using Aortic Homografts Emmanuel Martinod, MD, PhD ~ Assistance Publique – Hôpitaux de Paris Featured Presentation: Progress and Challenges in Tracheal Replacement Laura Niklason, MD, PhD ~ Yale University School of Medicine Featured Presentation: TBA TBA Featured Presentation: Recellularizing Tracheal Grafts Samuel Janes, MD, PhD ~ University College London Discussion
Free night in Burlington, Dinner on Your Own
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TUESDAY, JULY 28 TUESDAY, JULY 28
(Location: UVM Davis Center) (Location: UVM Davis Center)
6:30‐7:15 AM Shuttle bus looping between Hotel Vermont and UVM Campus 6:45‐7:15 Continental Breakfast and Continued Registration Grand Maple Ballroom, Davis Center, UVM Campus
7:15‐7:30
Welcome and Introduction
Session 2:
Endogenous Lung Progenitor Cells Moderator: Jason Rock, PhD ~ University of California, San Francisco
7:30‐8:10 8:10‐8:50
(30 minute talks followed by 10 min Q/A) Featured Presentation: Proximal Airway and Submucosal Gland Regeneration John Engelhardt, PhD ~ University of Iowa Featured Presentation: Human Airway Progenitor Cells in Health and Disease Renat Shaykhiev, MD, PhD ~ Weill Cornell Medical College
8:50‐9:30
Featured Presentation: Lung Cancer Stem Cells Mark Onaitis, MD ~ Duke University School of Medicine
9:30‐10:00
BREAK
10:00‐10:30 10:30‐11:00
(All subsequent talks: 20 min followed by 10 min Q/A) Epithelial‐Mesenchymal Crosstalk in Lung Fibrosis and Alveolar Homeostasis Christina Barkauskas, MD ~ Duke University School of Medicine A stepwise process regulating the neuroendocrine cell population and localization at the bifurcation points of the branching brochioles Mitsuru Morimoto, PhD ~ Riken Center for Developmental Biology (CDB)
11:00‐11:30
Travel Award Recipient: Interrogating the cellular diversity and biologic properties of mouse and human nasal epithelial basal cell (NEBC) progenitors Dawn Bravo, PhD ~ Stanford University School of Medicine
11:30‐12:00 PM
Travel Award Recipient: Defining the role of LRIG1‐dependent EGFR signaling pathway inhibition in airway homeostasis and lung cancer Laura Succony, BM ~ University College London
12:00‐12:45
Panel Moderated Discussion: Mouse vs Human Epithelial Progenitors Panelists: Brigitte Gomperts, MD ~ Mattel Children’s Hospital UCLA Susan Majka, PhD ~ Vanderbilt University Susan Reynolds, PhD ~ Nationwide Children’s Hospital Barry Stripp, PhD ~ Cedars‐Sinai Medical Center
12:45‐2:15
Mentoring Lunch
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Session 3: 2:15‐2:55 2:55‐3:35 3:35‐4:05 4:05‐4:35 4:35‐5:00 5:00‐5:30 5:30‐6:00 6:00‐6:45 6:45
Embryonic Stem Cells, iPS, and Lung Regeneration Moderator: Wellington Cardoso, MD, PhD ~ Columbia University (30 minute talks followed by 10 min Q/A) Featured Presentation: Lung Epithelial Progenitors and Differentiated Airway Epithelia from ESCs and iPS Cells: Progress and Pitfalls Paul Gadue, PhD ~ Children’s Hospital of Philadelphia Featured Presentation: Genome Editing and Disease Modeling: Applications to Studies of ESCs and iPS for Lung Diseases Chad Cowan, PhD ~ Harvard University (All subsequent talks: 20 min followed by 10 min Q/A) TALEN‐Targeted Lineage Reporters to Purify and Interrogate Human iPS‐Derived Lung Progenitors Finn Hawkins, MBBCh ~ Boston University School of Medicine iPS‐Derived Lung Epithelial Cells: Implications for Disease Amy Firth, PhD ~ Salk Institute of Biological Studies BREAK
Travel Award Recipient: Rejuvenation of aging alveolar stem cells using interrupted reprogramming Lily Guo, MD, MSc ~ Toronto General Hospital Research Institute Travel Award Recipient: Induced Pluripotent Stem Cell derived Vascular Smooth Muscle Cells Stabilizes Endothelial Vascular Network Formation Mirabelle S. H. Ho, PhD ~ Ottawa Hospital Research Institute Panel Discussion: Darrell Kotton, MD ~ Boston University School of Medicine Jay Rajagopal, MD ~ Massachusetts General Hospital Free night in Burlington Shuttle bus looping between UVM Campus and Hotel Vermont
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WEDNESDAY, JULY 29
6:45‐7:15 AM Shuttle bus looping between Hotel Vermont and UVM Campus
7:00‐7:30
Continental Breakfast
Session 4:
Bioengineering Approaches to Lung Regeneration
Moderator: Harald Ott, MD ~ Massachusetts General Hospital
7:15‐7:55 7:55‐8:35 8:35‐9:05 9:05‐9:35 9:35‐10:00
(30 minute talks followed by 10 min Q/A) Featured Presentation: Bioengineering Human Lung: From Screening Platforms to Whole‐Lung Approaches Gordana Vunjak‐Novakovic, PhD ~ Columbia University Featured Presentation: Immunologic Aspects of Lung Recellularization and Implantation Bryan Brown, PhD ~ University of Pittsburgh (All subsequent talks: 20 min followed by 10 min Q/A) Comparative Biology of Decellularized Lung Matrix Jenna Balestrini, PhD ~ Yale University School of Medicine Bioengineering the Lung’s Vasculature using hiPSC‐Derived Cells Charlie Xi Ren, PhD ~ Massachusetts General Hospital/Harvard Medical School BREAK
10:00‐10:30
Stiffness and Stretch Influences on Scaffold Regeneration Franziska Uhl, PhD ~ University of Vermont
10:30‐11:00
Anatomical and Integrin Specific Re‐endothelialization within Decellularized Rodent Lungs Collin Stabler, PhD student ~ Temple University
11:00‐11:30
Travel Award Recipient: Advanced methods for endothelial and epithelial cell seeding and culture for whole lung tissue Andrew Le, PhD ~ Yale University
11:30‐12:00 PM 12:00‐12:45 12:45‐1:00
Travel Award Recipient: Developing a Self‐Assembling Vascularized Airway Organoid as a Step toward Lung Regeneration Qi (Eric) Tan, PhD ~ Mayo Clinic Panel Discussion Christine Finck, MD ~ Connecticut Children’s Medical Center Peter Lelkes, PhD ~ Temple University Laura Niklason, MD, PhD ~ Yale University School of Medicine Angela Panoskaltsis‐Mortari, PhD ~ University of Minnesota BREAK/Lunch distribution
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1:00‐1:30
Lunchtime Featured Presentation: Lessons from Evolution: A Different Kind of Lung John West, MD, PhD ~ University of California – San Diego
1:30‐2:00 2:00‐2:30
Publishing and ethics in stem cell research Graham Parker, PhD ~ Wayne State University School of Medicine GROUP PHOTO AND BREAK
Session 5:
Careers in Stem Cells, Cell Therapies, and Lung Bioengineering
Moderators:
Darcy Wagner, PhD ~ Comprehensive Pneumology Center/Ludwig Maximilians University/Helmholtz Zentrum Munich Sarah Gilpin, PhD ~ Massachusetts General Hospital/Harvard Medical School
2:30‐3:30 3:30‐4:45 4:45‐5:45 4:45‐5:50 6:00‐9:00 9:00
Featured Presentation: Academic Careers in Lung Stem Cells/Cell Therapies/Bioengineering: Where Is This All Headed? Timothy Moore, MD, PhD ~ National Institutes of Health (NHLBI) An Overview of Peer Review at the NIH Center for Scientific Review Ghenima Dirami, PhD ~ National Institutes of Health
Poster Session Women and Diversity Reception Shuttle bus looping between UVM Campus and Hotel Vermont Dinner Cruise on Lake Champlain (Cruise Boards from 6:00‐6:30 and Departs promptly at 6:30pm) Shuttle bus returning from Cruise to Hotel Vermont
THURSDAY, July 30
6:45‐7:30 AM 7:00‐7:30
Shuttle bus looping between hotel and UVM Campus (Recommend bringing luggage to the meeting) Continental Breakfast
Session 6: EPCs, MSCs, and Cell Therapy Approaches for Lung Diseases
Moderator: Bernard Thébaud, MD, PhD ~ Ottawa Hospital Research Institute
7:30‐8:10
(30 minute talks followed by 10 min Q/A) Featured Presentation: Defining MSCs and EPCs: Consensus or Confusion Massimo Dominici, MD, President, ISCT ~ University of Modena
8:10‐8:50
Featured Presentation: Amniotic Fluid Cells and Lung Repair/Regeneration State of the Field Euan Wallace, MD ~ Southern Clinical School/Monash University
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8:50‐9:30
Featured Presentation: Bone Marrow-Derived Mononuclear Cells and Lung Repair/Regeneration: State of the Field Fernanda Cruz, MD, PhD ~ University of Vermont
9:30‐9:50
BREAK
9:50‐10:30
Update in Cell Therapy Clinical Trials for Lung Diseases and Critical Illnesses Kathleen Dori Liu, MD, PhD ~ UCSF School of Medicine
10:30‐11:00
(20 minute talks followed by 10 min Q/A) MSC Conditioned Media and the Microsome Fractions in Pre‐clinical Studies of Lung Diseases Antoine Monsel, MD ~ Hôpital Pitié Salpêtrière
11:00‐11:30
Amniotic Fluid Cells, Stretch, and Lung Bioengineering Charles Drinnan, PhD ~ University of Connecticut Health Center
11:30‐Noon Noon‐12:30 PM 12:30‐12:45 12:45‐1:30
Travel Award Recipient: Role of wnt/β‐catenin signaling at the virus‐host interface in stem/progenitor cell proliferative Carole Schmoldt, PhD ~ University of Giessen BREAK/Lunch distribution Panel Discussion w/box lunch: Daniel Chambers, MBBS, MD ~ The Prince Charles Hospital Laszlo Farkas, MD ~ Virginia Commonwealth University Jae‐Woo Lee, MD ~ University of California, San Francisco Duncan Stewart, MD ~ Ottawa Hospital Research Institute
Travel Award Recipient: Resident lung mesenchymal stromal cells are perturbed in experimental neonatal lung disease Kathleen Atkins ~ Ottawa Hospital Research Institute
Session 7:
Summation and Directions Moderator: Darwin Prockop, MD, PhD ~ Texas A&M Health Science Center COM
1:30‐2:00
Featured Presentation: Stem Cell‐based Products: FDA Update Donald Fink, Jr., PhD ~ US Food and Drug Administration
2:00‐3:00
Open Discussion: Setting Priorities and Recommendations to the NIH and Other Organizations Regarding Future Research Opportunities
Shuttle Bus looping between UVM Campus / Hotel Vermont / Airport
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