Slow Brain Oscillations of Sleep, Resting State and Vigilance

Slow Brain Oscillations of Sleep, Resting State and Vigilance Organized by the Netherlands Institute for Neuroscience (NIN), the VU University (VU), t...
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Slow Brain Oscillations of Sleep, Resting State and Vigilance Organized by the Netherlands Institute for Neuroscience (NIN), the VU University (VU), the University of Amsterdam (UvA) and the Leiden University Medical Center (LUMC) http://www.nin.knaw.nl/summerschool/ Tuesday June 29 – Friday July 2, 2010, official pre-FENS satellite Venue: Trippenhuis, Royal Netherlands Academy of Arts and Sciences (KNAW) Kloveniersburgwal 29, 1011 JC Amsterdam Organizers: Eus Van Someren, Ysbrand van der Werf, Pieter Roelfsema, Huibert Mansvelder, Fernando Lopes da Silva Implementation: Tini Eikelboom, Wilma Verwey, Henk Stoffels (NIN) The most important quest of cognitive neuroscience may be to unravel the mechanisms by which the brain selects, links, consolidates and integrates new information into its neuronal network, while preventing saturation to occur. During the last decade, neuroscientists working on the memory system within several disciplines and in many labs over the world have observed an important involvement of the specific types of brain oscillations that occur during sleep – the cortical slow oscillations; during the resting state – the MRI default mode and other networks; and during task performance – the EEG power and performance modulations. Understanding the role of these slow oscillations thus appear to be essential for our fundamental understanding of the essentials of brain function. Never before has an international meeting taken place that integrated these three fields of study and allowing for crossfertilization. Brain activity is characterized by oscillations; in spike frequency, field potentials or blood oxygen level-dependent MRI signals. Environmental stimuli, reaching the brain through our senses, activate, or inactivate, neuronal populations and modulate ongoing activity. In the absence of sensory input, as is the case during rest or sleep, brain activity does not cease. Rather, its oscillations continue and change with respect to their dominant frequencies and coupling topography. Studies ranging from the molecular, physiological and behavioral to the cognitive level have in the past decade clearly indicated that the study of these slow oscillations is essential for our understanding of plasticity, memory, brain structure from synapse to default mode network, cognition, consciousness and ultimately for our understanding of the mechanisms and functions of sleep and vigilance. At this 26th International Summer School an international selection of the most renowned scientists advancing these fields will present and discuss their work. The lectures will cover all levels of biological organization and are targeted at Ph.D-students, postdoctoral fellows and senior researchers, both in basic and clinical science, with an interest in plasticity, memory, sleep, vigilance, oscillations, default mode network activity, cognition and consciousness.

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Tuesday 29 June 2010 8:00 9:00

Registration Eus Van Someren: welcome and overview

Themes and Speakers (bold) including published example paper on topic I. Slow oscillations in detail and in perspective 9:15

Cellular and network mechanisms of recurrent cortical network activity Sanchez-Vives MV and McCormick DA (2000) Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nat Neurosci 3:1027-1034

10:00 Mechanisms of slow oscillations generation during sleep: neurons, glia and networks Amzica F and Massimini M (2002) Glial and neuronal interactions during slow wave and paroxysmal activities in the neocortex. Cerebr Cortex 12:1101-1113 10:45 Coffee break 11:15 Involvement of cytokines in slow wave sleep Krueger JM, Rector DM, Roy S, Van Dongen HP, Belenky G and Panksepp J (2008) Sleep as a fundamental property of neuronal assemblies. Nat Rev Neurosci 9:910-919. 12:00 Lunch II. Sleep and resting state EEG-profile as heritable endophenotype and during development 13:15 Genetic determination of sleep EEG profiles in mice Maret S, Franken P, Dauvilliers Y, Ghyselinck NB, Chambon P and Tafti M (2005) Retinoic acid signaling affects cortical synchrony during sleep. Science 310:111-113. 14:00 Genetic determination of sleep EEG profiles in man Retey JV, Adam M, Honegger E, Khatami R, Luhmann UF, Jung HH, Berger W and Landolt HP (2005) A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. PNAS 102:15676-15681. 14:45 Developmental aspects of slow oscillations during sleep Kurth S, Jenni OG, Riedner BA, Tononi G, Carskadon MA and Huber R (2009) Characteristics of sleep slow-waves in children and adolescents. Sleep in press 15:30 Tea break III. Genetic, cellular and small scale network mechanisms of local use-dependent slow oscillations 16:00 Modulation of cortical neuronal activity by vigilance state, behavior and preceding sleepwake history: cellular correlates of sleep homeostasis in freely behaving rats. Vyazovskiy VV, Cirelli C, Pfister-Genskow M, Faraguna U and Tononi G (2008) Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nat Neurosci 11:200-208. 16:45 Involvement of adenosine in slow wave sleep Halassa MM, Florian C, Fellin T, Munoz JR, Lee SY, Abel T, Haydon PG and Frank MG (2009) Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron 61:213-219 18:00 Reception and buffet at the West-Indisch Huis

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Wednesday 30 June 2010 IV. Phasic events during slow oscillations: 9:00

Impact of brainstem network activity on cortical dynamics during slow oscillations Mena-Segovia J, Sims HM, Magill PJ and Bolam JP (2008) Cholinergic brainstem neurons modulate cortical gamma activity during slow oscillations. J Physiol 586:2947-2960.

9:45

Grouping of spindle activity during slow oscillations in sleep Molle M, Marshall L, Gais S and Born J (2002) Grouping of spindle activity during slow oscillations in human non-rapid eye movement sleep. J Neurosci 22:10941-10947.

10:30 Coffee break 11:00 Spontaneous neural activity during human slow wave sleep Dang-Vu TT, Schabus M, Desseilles M ... and Maquet P. (2008) Spontaneous neural activity during human slow wave sleep. PNAS 105:15160-15165. 11:45 Lunch and poster session V. Thalamocortical network interactions during slow sleep oscillations 13:15 Neuronal plasticity in thalamocortical networks during sleep and waking oscillations Steriade M and Timofeev I (2003) Neuronal plasticity in thalamocortical networks during sleep and waking oscillations. Neuron 37:563-576. 14:00 Thalamocortical mechanisms of slow oscillations Crunelli V, Blethyn KL, Cope DW, Hughes SW, Parri HR, Turner JP, Toth TI and Williams SR (2002) Novel neuronal and astrocytic mechanisms in thalamocortical loop dynamics. Philos Trans R Soc Lond B Biol Sci 357:1675-1693. 14:45 Tea break VI. Cortico-hippocampal network interactions and replay during slow oscillations 15:15 The dynamics of memory reactivation and cortico-hippocampal interactions Johnson LA, Euston DR, Tatsuno M and McNaughton BL (in press). Stored-trace reactivation in rat prefrontal cortex is correlated with down-toup state transitions in neuronal ensemble activity. J Neurosci. 16:00 Coordinated memory replay in the visual cortex and hippocampus during sleep Ji D and Wilson MA (2007) Coordinated memory replay in the visual cortex and hippocampus during sleep. Nat Neurosci 10:100-107. 16:45 Communication between neocortex and hippocampus during sleep in rodents Sirota A, Csicsvari J, Buhl D and Buzsaki G (2003) Communication between neocortex and hippocampus during sleep in rodents. PNAS 100:2065-2069.

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Thursday 1 July 2010 VII. Cortical synchronization and travelling of slow oscillations 9:00

Microvascular compliance changes across sleep and wake: mechanisms for local sleep regulation Rector DM, Schei JL, Van Dongen HP, Belenky G and Krueger JM (2009) Physiological markers of local sleep. The European journal of neuroscience 29:1771-1778.

9:45

Long range synchronization of up and down states Volgushev M, Chauvette S, Mukovski M and Timofeev I (2006) Precise long-range synchronization of activity and silence in neocortical neurons during slow-wave oscillations. J Neurosci 26:5665-5672

10:30 Coffee break 11:00 The sleep slow oscillation as a traveling wave Massimini M, Huber R, Ferrarelli F, Hill S and Tononi G (2004) The sleep slow oscillation as a traveling wave. J Neurosci 24:6862-6870. 11:45 Sources of slow oscillation travelling waves; overlap with the default mode network? Murphy, M., Riedner, B.A., Huber, R., Massimini, M., Ferrarelli, F. and Tononi, G. (2009) Source modeling sleep slow waves. PNAS, 106: 1608-1613. 12:30 Lunch and poster session VIII. Functional benefits of slow oscillations during sleep 14:15 Mechanisms of sleep-dependent consolidation of cortical plasticity Aton SJ, Seibt J, Dumoulin M, Jha SK, Steinmetz N, Coleman T, Naidoo N and Frank MG (2009) Mechanisms of sleep-dependent consolidation of cortical plasticity. Neuron 61:454466. 15:00 Sleep slow oscillations for memory consolidation Marshall L, Helgadottir H, Molle M and Born J (2006) Boosting slow oscillations during sleep potentiates memory. Nature 444:610-613. 15:45 Tea break 16:15 Sleep benefits subsequent hippocampal functioning Van Der Werf YD, Altena E, Schoonheim MM, Sanz-Arigita E, Vis JC, De Rijke W and Van Someren EJW (2009) Sleep benefits subsequent hippocampal functioning. Nat Neurosci 12:122-123 18:00 Dinner

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Friday 2 July 2010 IX. What comes to mind 9:00

Resting state networks as seen via FMRI: Characteristics and interpretations Smith, SM, Fox PT, Miller KL, Glahn DC, Fox PM, Mackay CE, Filippini N, Watkins KE, Toro R, Laird AR and Beckmann CF (2009) Correspondence of the brain's functional architecture during activation and rest. PNAS 106:13040-13045.

9:45

Resting state default network oscillations interfacing vigilance and sleep Larson-Prior LJ, Zempel JM, Nolan TS, Prior FW, Snyder AZ and Raichle ME (2009) Cortical network functional connectivity in the descent to sleep. PNAS 106:4489-4494

10:30 Coffee break 11:00 Low frequency BOLD fluctuations during resting wakefulness and light sleep Horovitz SG, Fukunaga M, de Zwart JA, van Gelderen P, Fulton SC, Balkin TJ and Duyn JH (2007) Low frequency BOLD fluctuations during resting wakefulness and light sleep: A simultaneous EEG-fMRI study. Hum Brain Mapp 11:45 Lunch break and poster session X. Slow oscilations in the competition between vigilant performance and resting state 13:15 Daydreaming your way out of coma? fMRI restings state studies in disorders of consciousness Boly M, Balteau E, Schnakers C, Degueldre C, Moonen G, Luxen A, Phillips C, Peigneux P, Maquet P and Laureys S (2007) Baseline brain activity fluctuations predict somatosensory perception in humans. PNAS 104:12187-12192. 14:00 Very slow EEG fluctuations predict the dynamics of stimulus detection Monto S, Palva S, Voipio J and Palva JM (2008) Very slow EEG fluctuations predict the dynamics of stimulus detection and oscillation amplitudes in humans. J Neurosci 28:82688272. 14:45 Tea break 15:15 Infraslow oscillations in drowsy performance and EEG Huang, R.-S., Jung, T.-P., Delorme, A. & Makeig, S. Tonic and phasic electroencephalographic dynamics during continuous compensatory tracking. NeuroImage 39, 1896–1909 (2008). 16:00 Closing and drinks

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