Serum vitamin D among children with inherited metabolic disorders

Oregon Health & Science University OHSU Digital Commons Scholar Archive November 2012 Serum vitamin D among children with inherited metabolic disor...
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Oregon Health & Science University

OHSU Digital Commons Scholar Archive

November 2012

Serum vitamin D among children with inherited metabolic disorders Katie Elizabeth Geiger

Follow this and additional works at: http://digitalcommons.ohsu.edu/etd Recommended Citation Geiger, Katie Elizabeth, "Serum vitamin D among children with inherited metabolic disorders" (2012). Scholar Archive. Paper 963.

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Serum Vi t amin D Among Children with Inherited Metabolic Disorders

Katie Elizabeth Geiger

A THESIS

Submitt ed to the Facuity of the Graduate Programs in Human Nutrition And the Oregon Health & Science University School of Medicine in partial fulfillment of

the requirement s for the degree of Mast er of Science

Oinical Nutrition November 2012

xhool of Medicine Oregon Health & Science

Uni~€rsity

,

TABLE OF CONTENTS

Pa.ge

Acknowledgements

iii

Ust of Abbreviations and Acronyms

i.

l ist of Figures list of Tab les

" ."

Abstr~ct

Chapter 1 .

Chapter 2.

Introduction

1

Specific Aims and Hypotheses

3

Background and Significance

6

Discovery of PKU

6

Disease Mechanism

,

Diagnosis, Treatment and Compliance

8

Vit~min

D and Bone Mineral Density

Vitamin D: A

Perspective

15

Vitamin D Deficiency ~nd 05teopenia

"

Vitamin D Recommendations

18

PKU, Vitamin D, and Bone Mineral Density

19

Further Chapter 3.

Historic~1

11

Rese~rch

Needed

03

Methods

24

General Design

24

Blood Sample Collection and An alySiS

26

Bone Mineral Densi ty and Measurements

"

Chapter 4.

Dietary Intake Analysis

"

Stati~tical Analy~i5

29

Results

31

Aim 1 Deseri ptive Characteristic5

31

Stati~tical Analy~i~

36

Unconditional Logistic RegreS5ion Analysis

37

Aim2 Descriptive

Chapter S.

Characteristic~

39

Biochemical Analysis

39

Dietary Intake

43

Bone Mineral Density

"

Correlation Analysis

44

Discussion

51

Aim 1 Summary

51

Aim 1 Summary

54

Future Research

58

Conclusion

59

Appendix 1

6
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