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Serum vitamin D among children with inherited metabolic disorders Katie Elizabeth Geiger
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Serum Vi t amin D Among Children with Inherited Metabolic Disorders
Katie Elizabeth Geiger
A THESIS
Submitt ed to the Facuity of the Graduate Programs in Human Nutrition And the Oregon Health & Science University School of Medicine in partial fulfillment of
the requirement s for the degree of Mast er of Science
Oinical Nutrition November 2012
xhool of Medicine Oregon Health & Science
Uni~€rsity
,
TABLE OF CONTENTS
Pa.ge
Acknowledgements
iii
Ust of Abbreviations and Acronyms
i.
l ist of Figures list of Tab les
" ."
Abstr~ct
Chapter 1 .
Chapter 2.
Introduction
1
Specific Aims and Hypotheses
3
Background and Significance
6
Discovery of PKU
6
Disease Mechanism
,
Diagnosis, Treatment and Compliance
8
Vit~min
D and Bone Mineral Density
Vitamin D: A
Perspective
15
Vitamin D Deficiency ~nd 05teopenia
"
Vitamin D Recommendations
18
PKU, Vitamin D, and Bone Mineral Density
19
Further Chapter 3.
Historic~1
11
Rese~rch
Needed
03
Methods
24
General Design
24
Blood Sample Collection and An alySiS
26
Bone Mineral Densi ty and Measurements
"
Chapter 4.
Dietary Intake Analysis
"
Stati~tical Analy~i5
29
Results
31
Aim 1 Deseri ptive Characteristic5
31
Stati~tical Analy~i~
36
Unconditional Logistic RegreS5ion Analysis
37
Aim2 Descriptive
Chapter S.
Characteristic~
39
Biochemical Analysis
39
Dietary Intake
43
Bone Mineral Density
"
Correlation Analysis
44
Discussion
51
Aim 1 Summary
51
Aim 1 Summary
54
Future Research
58
Conclusion
59
Appendix 1
6
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