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ISSN: 0973-4945; CODEN ECJHAO E-Journal of Chemistry 2012, 9(3), 1196-1205

Screening for Hypoglycemic Activity on The Leaf Extracts of Nine Medicinal Plants: In-Vivo Evaluation ADITYA ARYA,1, 2* MAHMOOD AMEEN ABDULLAH,3BATOUL SADAT HAERIAN,1 AND MUSTAFA ALI MOHD1* 1

Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia 2 Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia 3 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia [email protected] [email protected] Received 3 November 2011; Accepted 7 January 2012

Abstract: The traditional use of certain plants by the tribal community in central India involves using the young leaves for several ailments, including hyperglycaemia; this study was performed to evaluate the effects of the leaf extracts from 9 such plants in the management of diabetes. Initially, hypoglycemic screening was performed on normal rats whose blood glucose levels were measured before and after oral or intraperitoneal (i.p.) administration of the extracts at different periods. The plants were screened at doses of 250 mg/kg i.p. or 500 mg/kg orally. Of these, only Centratherum anthelminticum (Asteraceae), Cissus quadrangularis (Vitaceae), and Woodfordia fruticosa Kurz (Lythraceae) significantly reduced postprandial blood glucose levels in normal glycemic rats (P