SCIENTIFIC PROGRAM

www.toll2018.org

INDEX

WELCOME LETTER............................................................. 4 COMMITTEE............................................................................ 5 GENERAL INFORMATION................................................ 6 CONGRESS FLOOR PLAN................................................ 8 SCIENTIFIC PROGRAM Wednesday, June 6th...................................................... 11 Thursday, June 7th............................................................ 15 Friday, June 8th.................................................................. 21 Saturday, June 9th............................................................ 27 POSTER................................................................................... 33 SPONSORS AND EXHIBITORS.................................... 95

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Welcome Letter Dear friends and colleagues, It is with great pleasure that we invite you to the TOLL2018 conference to be held from 6th to 9th June in Porto in Portugal. Toll2018, like the previous five meetings, aims at displaying and challenging most recent developments in cellular innate immunity. Areas of particular interest are host-pathogen interactions, pattern recognition receptors, cellular signaling and immunometabolism, and myeloid cell development. Furthermore, we wish to explore the implications of improved knowledge in innate immune mechanisms for diagnosing and treating diseases. The Toll meetings are all about communication and networking between a world class faculty, ranging from developmental biologists to translational scientists, and new and established researchers in the field. Porto, the UNESCO World Heritage Site with its dramatic location along the Douro river, and the historic Alfandega congress center offer a wonderful environment for intense and lasting interactions. We are looking forward to define – together with you – the leading edge in understanding and manipulating innate immunity.

Douglas T. Golenbock MD Department of Medicine University of Massachusetts Medical School. USA

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Philipp Henneke MD Center for Pediatrics & Center for Chronic Immunodeficiency Medical Center – University of Freiburg, Germany

Committee Organizing Committee Chairs: Douglas Golenbock Philipp Henneke Kate Fitzgerald Ricardo Gazzinelli Eicke Latz Egil Lien Kenneth Rock Neal Silverman

Scientific Partner

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General Information Venue Centro de Congressos da Alfandega do Porto Rua Nova da Alfândega – Edifício da Alfândega - 4050-430 Porto - Portugal GPS coordinates: 41.1430389,-8.6217094

Technical Secretariat Opening Hours Wednesday June 6th Thursday June 7th Friday June 8th Saturday June 9th

09:00 - 19:00 08:30 - 19:10 08:30 - 21:15 08:30 - 18:50

Certificate Attendance Participants will receive their Certificates of Attendance by email one week after the Congress.

APP Download and Install the mobile APP of the Toll Meeting, get all info in your device. Available for: iPhone, iPad and Android devices. Use the following CODE to unlock the application, when is requested: 39418

Congress Name Badge On arrival, at the registration counter you will receive your name badge. Please wear your badge at all times at the Congress, during all sessions and events.

Currency All official congress prices are indicated in Euro €. The official currency in Portugal is the Euro €. All major credit cards are accepted in most hotels, restaurants, and shops.

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Liability and Insurance The Congress Secretariat and organizers are not and cannot accept liability for personal accidents or loss of or damage to private property of participants. Participants are advised to take their own personal travel and health insurance for their trip.

Safety and Security Please, do not leave bags or suitcases unattended at any time, whether inside or outside the session halls. Hotels strongly recommend that you use their safety deposit for your valuables.

WiFi WiFi will be available for participants at the venue during all the Congress. User: TOLL2018 Password: PORTO2018

Mobile Phones and Photography Participants are kindly requested to keep their mobile phones switched off at the halls when attending session’s and refrain from taking pictures during sessions.

Official Language The official language of the congress is English.

Smoking Policies The TOLL Meeting is non-smoking event and participants are requested to refrain from smoking in the venue.

Congress Organizers Kenes Group

Calle Eraso 36, 2º 28028, Madrid +34 91 361 2600

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Congress Floor Plan GROUND FLOOR

WEST GROUND FLOOR Exhibition Area,  Poster Area,  Speakers Preview Catering Area

ENTRANCE

ENTRANCE TO ALFANDEGAS

1

NOBLE HALL CAIS/QUAY

1

STAIRS TO THE 2nd FLOOR Elevators Toilets

8

2nd FLOOR

ARCHIVE HALL 2

INFANTE HALL

2

Access

CONGRESS SECRETARIAT Elevators Toilets

9

Scientific Program

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Wednesday, June 6th

ROOM ARCHIVE HALL 9:00-13:00

REGISTRATION

13:00-13:15

OPENING

13:15-15:15

IMMUNITY TO BACTERIA I

15:15-15:45

COFFEE BREAK

15:45-17:45

CELLULAR TRANSFORMATION AND INNATE IMMUNITY

17:45-18:15

COFFEE BREAK

18:15-19:00

KEY NOTE LECTURE

19:00-21:30

NETWORKING EVENT I: SCIENCE AND PORTUGUESE SPECIALITIES

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Wednesday, June 6th

Wednesday, June 6th 13:00 - 13:15

Opening

Room Archive Hall



Douglas Golenbock and Philipp Henneke

13:15 - 15:15

Immunity to bacteria I

Room Archive Hall



Chairs: Margarida Saraiva and Philipp Henneke



Greg Barton (USA) New mechanisms controlling self vs. non-self discrimination by TLRs



Neal Silverman (USA) Functional amyloids in innate immune signal transduction

Selected: Trude Flo (Norway) Single-cell dynamics of pyroptosis in M. tuberculosis infected macrophages

Dana Philpott (Canada) The role of NOD-like receptors in intestinal homeostasis



Arturo Zychlinsky (Germany) Mechanisms of net formation

15:15 - 15:45

Coffee break

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Cellular transformation and innate immunity

Room Archive Hall

Chairs: Kate Fitzgerald and Paul Herzog

Andrea Ablasser (Switzerland) Small molecule-mediated targeting of STING



Stefanie Vogel (USA) How influenza “retrains” the host for increased susceptibility to secondary bacterial infection

Selected: Colin Adrain (Portugal) Identification and physiological characterization of a novel protein essential for TNF release in humans and mice

Judy Lieberman (USA) The search for gasdermin inhibitors

Douglas Golenbock (USA) The development of innate immune training in falciparum malaria 17:45 - 18:15

Coffee break

18:15 - 19:00

Key note lecture

Room Archive Hall

Chair: Eicke Latz

Emmanuelle Charpentier (Germany) CRISPR-Cas9: A bacterial immune system harnessed as a revolutionary genetic engineering technology

19:00 - 21.30

Networking Event I: Science and Portuguese Specialities

13

Wednesday, June 6th

15:45 - 17:45

Scientific Program

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Thursday, June 7th

ROOM ARCHIVE HALL 09:00-11:00

IMMUNITY TO PARASITES & INTRACELLULAR BACTERIA I

11:00-11:25

COFFEE BREAK

11:25-13:25

IMMUNITY TO VIRUSES

13:35-14:35

POSTER AND LUNCH Exhibition Area

13:35-14:35

INNATE IMMUNE MODIFIERS FROM BENCH TO BEDSIDE Sponsored by the Pillar Group (Lunch will be available)

14:45-16:45

IMMUNITY TO BACTERIA II

16:45-17:10

COFFEE BREAK

17:10-19:10

IMMUNITY TO PARASITES & INTRACELLULAR BACTERIA II

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Thursday, June 7th

Thursday, June 7th 09:00 - 11:00

Immunity to parasites & intracellular bacteria I

Room Archive Hall

Chairs: Egil Lien and Clare Bryant

Bruno Lemaitre (Switzerland) Drosophila antimicrobial peptides: popular so far, but what are they really doing?

P’ng Loke (USA) Alternatively activated M2 macrophages during helminth infections Selected: André Barateiro (Brazil) AIM2 and NLRP3 inflammasomes induce poor pregnancy outcomes through IL1 axis activation during placental malaria

Terje Espevik (Norway) Phagocytic signalling for antibacterial defence



Ricardo Gazzinelli (Brazil) The circadian cycle in malaria

11:00 - 11:25

Coffee break

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Immunity to viruses

Thursday, June 7th

11:25 - 13:25 Room Archive Hall

Chairs: Shizuo Akira and Stefanie Vogel

Lynda Stuart Transposon mutagenesis screens for host resistance



Sara Cherry (USA) Harnessing functional genomics to explore the interface between viruses and hosts

Selected: Lorena Zuliani-Alvarez (UK) cGAS is activated by HIV-2, but not HIV-1, in primary human macrophages

Katherine Fitzgerald (USA) Regulation of inflammatory responses



Paul Hertzog (Australia) Interferon epsilon regulates protective immunity in mucosal infection and tumourigenesis

13:35 - 14:35

Poster and Lunch

Exhibition Area

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Thursday, June 7th

13:35 - 14:35 Room Archive Hall

Innate immune modifiers from bench to bedside Sponsored by the Pillar Group (Lunch will be available)

Chair: Sudhir Agrawal

Cara Haymaker, MDACC TLR9 agonist harnesses innate immunity to drive tumorinfiltrating T-cell expansion in distant lesions in a phase 1/2 study of intratumoral IMO-2125 + ipilimumab in anti-PD1 refractory melanoma patients



Alexander Poltorak, Tufts Sting modulators

14:45 - 16:45

Immunity to bacteria II

Room Archive Hall

Chairs: Andrea Ablasser and Terje Espevik

Lalita Ramakrishnan (UK) A TNF-mediated mitochondrial-lysosomal-ER circuit mediates pathogenic macrophage necrosis in tuberculosis.



Yasmine Belkaid (USA) Non classical immunity to the microbiota

Selected: Alanna Cameron (Germany) NAD salvage and DNA damage in inflammatory macrophages

Philipp Henneke (Germany) The daily grind of skin macrophages



Steven Holland (USA) Rac2, Brute?

16:45 - 17:10

Coffee break

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Immunity to parasites & intracellular bacteria II

Room Archive Hall

Chairs: Steven Holland and Maria Mota

Shankar Ghosh (USA) Targeting of chromatin-remodeling factors by micro RNAs regulate innate immune memory in sepsis



Dominique Ferrandon (France) The yin and the yang of host defense: resilience to infections and environment mediated by the cytoplasmic or lipidic purges of enterocytes

Selected: Hiromitsu Hara (Japan) A novel receptor recognizing mycobacterium cell wall lipids that regulates mincle-induced inflammation

Clare Bryant (UK) Pattern recognition receptor recognition of bacterial pathogens



Sergio Grinstein (Canada) Molecular mechanisms of phagocytosis

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Thursday, June 7th

17:10 - 19:10

Scientific Program

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Friday, June 8th

ROOM ARCHIVE HALL

ROOM INFANTE HALL

09:00-11:00

SELECTED ABSTRACTS Parallel Session I

SELECTED ABSTRACTS Parallel Session II

11:00-11:20

COFFEE BREAK

11:20-13:00

GENE AND SIGNALING REGULATION

13:00-17:30

EXPLORING PORTO (Individual/ organized)

17:30-19:10

MONOCYTES, MACROPHAGES AND BEYOND Sponsored by the Portuguese Society of Immunology SPI Session I

19:10-19:35

WINE AND OLIVES/BREAD

19:35-21:15

SPI Session II

21:15-22:45

NETWORKING EVENT II: POSTERS AND PETISCOS

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Friday, June 8th

Friday, June 8th 09:00 – 11:00 Room Archive Hall

Selected abstracts Parallel Session I

Chairs: Eicke Latz and Greg Barton

Manfred Kopf (Switzerland) The mechanism of NRF2-mediated inflammasome activation



Read Pukkila-Worley (USA) A conserved nuclear hormone receptor functions in small molecule surveillance to drive a protective immune response in c. elegans



Dario Zamboni (Brazil) The leishmania lypophosphoglycan triggers caspase-11 and the non-canonical activation of the NLRP3 inflammasome



Dan Weng (China) RIP1 contributes to er stress-induced inflammasome activation



Jack Green (UK) Chloride channel activity is necessary for activation of the NLRP3 inflammasome

Paula Saz-Leal (Spain) Boosting trained immunity by targeting SHIP-1 in myeloid cells

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Susan Carpenter (USA) Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2

Room Infante Hall

Selected abstracts Parallel Session II

Chairs: Ann Rothstein and Miguel Soares Samuel Keating (Netherlands) Lysine methylation sets the scene for innate immune memory Alberto Yanez (USA) Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes

Iain Fraser (USA) A genome-wide screen identifies a critical role for mitochondrial NDP kinases in inflammasome activation

Leonie Unterholzner (UK) cGAS-dependent and cGAS-independent modes of STING activation result in different signalling outcomes in human cells

Mojca Benčina (Slovenia) Short DNA degradation products augment activation of tolllike receptor 9 with mammalian genomic DNA



Nicolas Manel (France) Implication of nuclear cGAS in the recognition of HIV and self-DNA in the nucleus



Manuele Rebsamen (Austria) Systematic mapping of necroptosis genes identifies SLC39A7 as modulator of immune receptor trafficking

11:00 – 11:20

Coffee break

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Friday, June 8th

09:00 – 11:00

Friday, June 8th

11:20 - 13:00

Gene and signaling regulation

Room Archive Hall

Chairs: Veit Hornung and Virginia Pascual

Hao Wu (USA) Structures and functions of gasdermins in pyroptosis and IL-1 release



Caetano Reis e Sousa (UK) Understanding the dendritic cell network in innate and adaptive immunity



Steve Smale (USA) Molecular mechanisms transcriptional cascades



Chris Glass (USA) Decoding gene by environment interactions that regulate macrophage phenotypes

13:00 - 17:30

Exploring Porto (Individual/ organized)

17:30 - 19:10

Monocytes, macrophages and beyond I Sponsored by the Portuguese Society of Immunology

Room Archive Hall

regulating

stimulus-specific

Chairs: Dana Philpott and Nuno Alves

Miguel Soares (Portugal) Metabolic regulation of disease tolerance to infection



Luis Teixeira (Portugal) Growth regulation of the antiviral symbiont wolbachia

Ricardo Silvestre (Portugal) Immunometabolic networks interactions 24

regulating

Miriam Merad (USA) Myeloid cells control of tumor immunity

host-pathogen

Wine and olives/ bread

19:40 - 21:20

Monocytes, macrophages and beyond II Sponsored by the Portuguese Society of Immunology

Room Archive Hall

Friday, June 8th

19:10 - 19:40

Chairs: Luke O ‘Neill and Luis Graça

Maria Mota (Portugal) Plasmodium ability to control host autophagy



Alexandre Carmo (Portugal) The role of SRCR proteins in infection and inflammation



Marc Veldohen (Portugal) Maintaining intestinal epithelial T cells



Vishva Dixit (USA) Death of innate immune cells drives inflammation

21:15 - 22:45

Networking Event II Posters and Petiscos

25

Scientific Program

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Saturday, June 9th

ROOM ARCHIVE HALL 09:00-11:00

METABOLISM AND IMMUNE REGULATION

11:00-11:25

COFFEE BREAK

11:25-13:05

AUTOIMMUNITY AND INTERFERONS

13:10-14:10

POSTER AND LUNCH Exhibition Area      

13:10-14:10

MEET THE EDITORS (Lunch will be available)

14:20-16:20

INFLAMMATION IN SPECIFIC NICHES

16:20-16:50

COFFEE BREAK

16:50-18:50

MUCOSAL IMMUNITY

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Saturday, June 9th

Saturday, June 9th 09:00 - 11:00

Metabolism and immune regulation

Room Archive Hall

Chairs: Neal Silverman and Judy Lieberman

Jonathan Kagan (USA) Regulation of innate immunity



Ken Rock (USA) Identification and characterization of a novel damp receptor

Selected: Musa Mhlanga (South Africa) Trained immune genes are regulated by LncRNAs in discrete nuclear compartments

Egil Lien (USA) Bacterial secretion systems target pathways controlling GSDMD cleavage



Luke O’Neill (Ireland) Krebs cycle reprogrammed for cytokines

11:00 - 11:25

Coffee break

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Autoimmunity and interferons

Saturday, June 9th

11:25 - 13:05 Room Archive Hall

Chairs: Ken Rock and Yasmine Belkaid

Virginia Pascual (USA) Tba



Veit Hornung (Germany) Inflammasome signaling in the human system



Ann Marshak-Rothstein (USA) TLR9 Regulation of Systemic Autoimmunity



James Chen (USA) Innate Immune Sensing of DNA through cGAS

13:10 - 14:10

Poster and Lunch

Exhibition Area    

13:10– 14:10

Meet the Editors

Room Archive Hall

(Lunch will be available)



Chairs: Kate Fitzgerald and Gaia Trincucci Which papers are we looking for? How do we wish to communicate with the authors? Which misperceptions by authors are common? What do we expect from revisions?



A round table discussion with: Ursula Weiss (Nature), Peter Lee (Immunity), Sri Devi Narasimhan (Cell), Alejo Chorny (J. Experimental Medicine), Ioana Visan (Nature Inmunology) Sara Hamilton (Cell Reports)

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Saturday, June 9th

14:20 - 16:20

Inflammation in specific niches

Room Archive Hall

Chairs: Sara Cherry and Riccardo Gazzinelli

Gabriel Núñez (USA) NOD2, the microbiota and intestinal inflammation

Eicke Latz (Germany) Posttranslational regulation of NLRP3 inflammasome activation Selected: Kate Schroder (Australia) A new model for inflammasome function and signal termination via an intrinsic proteolytic timer Michael Heneka (Germany) NLRP3 knockout protects from tau pathology in TAU22 mice

Shizuo Akira (Japan) Towards understanding the mechanism of fibrosis

16:20 – 16:50

Coffee break

30

Mucosal immunity

Saturday, June 9th

16:50 - 18:50 Room Archive Hall

Chairs: Lalita Ramakrishnan and Douglas Golenbock

Eran Elinav (Israel) Host microbiome interactions in health and disease



Richard Flavell (USA) New guardians of mucosal immunity



Marco Colonna (USA) Innate immunity in neurodegeneration



David Artis (USA) Immune regulation at barrier surfaces

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Posters

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POSTER TOPIC INDEX

TLR SIGNALING

1 - 108

INTERFERON SIGNALING

109 - 129

ANTIVIRAL SIGNALING

130 - 166

MYELOID DEVELOPMENT

167 - 177

IMMUNITY TO PARASITES

178 - 197

NLR/ INFLAMMASOME

198 - 285

FLY IMMUNITY

286 - 292

INTRACELLULAR PATHOGENS

293 - 330

SUBCELLULAR SIGNALING

331 - 348

MISCELLANEOUS

349 - 390

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Posters

TLR SIGNALING 1.00 EFFECT OF INTESTINAL MICROBIOTA ON THE EXPRESSION OF INNATE IMMUNITY FACTORS GALT OF RAT IN CONDITIONS OF CHRONIC SOCIAL STRESS Inna Topol1 1. Zaporozhye State Medical University 2.00 MODULATING EFFECTS OF OMEGA-3 FATTY ACIDS AND PIOGLITAZONE COMBINATION ON INSULIN RESISTANCE THROUGH TOLL-LIKEE RECEPTOR 4 IN TYPE 2 DIABETES MELLITUS Laila Eissa, Noha Abdel-Rahman, Salma Eraky 1. Biochemistry Department,Faculty Of Pharmacy,Mansoura Unversity  3.00 CONVERTION OF A TLR7-ACTIVATING RNA INTO A TLR8-SPECIFIC LIGAND BY 2’-O- METHYLATION Stephanie Jung1,2, Tina von Thuelen1, Stefan Bauer1 1. Philipps-University, Marburg, Germany  2. current affiliation: German Research Center for Environmental Health, Munich, Germany 4.00 A TRANSMEMBRANE ADAPTOR FOR TOLL-LIKE RECEPTORS PROMOTES SELECTIVE PROINFLAMMATORY RESPONSES Lin Luo1, James Curson1, Adam Wall1, Samuel Tong1, Matthew Sweet1, Jennifer Stow1 1. Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, Brisbane, Queensland, 4072, Australia  5.00 NUCLEIC ACID DEPENDENT RECOGNITION OF S. PYOGENES BY THE INNATE IMMUNE SYSTEM IN VITRO AND IN VIVO Tatjana Eigenbrod1, Anna Hafner1, Ulrike Kolbe1, Isabel Freund1, Virginia Castiglia2, Pavel Kovarik2, Tanja Poth1, Alexander Dalpke1 1. University Hospital Heidelberg  2. Max F. Perutz Laboratories 6.00 SLAMF1 REGULATES TLR4 SIGNALING IN HUMAN MACROPHAGES Mariia Yurchenko1, Astrid Skjesol1, Harald Husebye1, Terje Espevik1 1. Norwegian University of Science and Technology 7.00 GUANABENZ INHIBITS TLR9 SIGNALING VIA A GADD34-INDEPENDENT PATHWAY AND CH25H DOWN-MODULATION Philippe Pierre1, Jessica Perego, Andreia Mendes, Clarisse Bourbon, Evelina Gatti 1. Centre d’Immunologie de Marseille- Luminy  8.00 ASSOCIATIONS OF TOLL-LIKE RECEPTOR 7 AND 8 POLYMORPHISMS WITH ASTHMA AND ASTHMA-RELATED PHENOTYPES IN A CHINESE HAN POPULATION Qian Zhang1, Xiao-Wei Yin1, Qi Cao1 1. Affiliated Changzhou No.2 People’s Hospital, Nanjing Medical University  34

10.00 TLR-ADJUVANTS UTILIZE CD169+ MACROPHAGES DIFFERENTLY LEADING TO DIFFERENTIAL ANTIBODY PROFILES Christina Lisk1, Lee Wetzler1, Michael Reiser2, Rachel Yuen 1 1. Boston University School of Medicine, Boston, MA, USA  2. BioNTech RNA Pharmaceuticals, Mainz, Rhineland, Germany 11.00 TLR ADJUVANTS INFLUENCE ANTIGEN DEPOSITION ON FOLLICULAR DENDRITIC CELLS Christina Lisk1, Rachel Yuen1, Michael Reiser2, Lee Wetzler1 1. Boston University School Of Medicine  2. BioNTech RNA Pharmaceuticals, Mainz, Rhineland, Germany   12.00 TLR10 IS AN INHIBITORY PATTERN RECOGNITION RECEPTOR ACTING THROUGH IL-1RA Marije Oosting, Vera Mourits, Mihai Netea, Leo Joosten 1. Radboudumc  13.00 THE FUNCTIONAL GENOMIC ARCHITECTURE OF TRAINED IMMUNITY AND INNATE IMMUNE TOLERANCE Simone Moorlag1, Yang Li2, Marije Oosting1, Rutger Jan Röring1, Vera Mourits1, Sanne Smeekens1, Raul Gamboa2, Vasiliki Matzaraki2 Niels Riksen1 Mihai Netea1 1. Radboud University Medical Center, Nijmegen.The Netherlands  2. University Medical Center Groningen, Groningen, The Netherlands 14.00 AUTOPHAGY INHIBITION MODIFIES THE INNATE RESPONSE OF HUMAN PLASMACYTOID DENDRITIC CELLS Paulo Antas1, Carolina Silva1, Voahirana Camosseto2, Evelina Gatti1,2, Catarina Almeida1,3, Philippe Pierre1,2 1. IBiMED - Institute of Biomedicine, University Of Aveiro  2. CIML - Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, France 3. Department of Medical Sciences, University of Aveiro, Portugal 15.00 MODULATION OF PEROXIREDOXIN-5 EXPRESSION BY LPS AND MICRORNAS IN MOUSE AND HUMAN PHAGOCYTES Sarah Becker1, Eric Lauwers1, Julien Glibert1, Alice Haumont1 1. Université Catholique De Louvain 

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Posters

9.00 STAPHYLOCOCCUS AUREUS VIRULENT PSMα PEPTIDES INDUCE KERATINOCYTE ALARMIN RELEASE TO ORCHESTRATE MYD88-DEPENDENT IL-17-MEDIATED SKIN INFLAMMATION Masanori Matsumoto1, Seitaro Nakagawa2, Michael Otto3, Yumi Nakamura2, Gabriel Nunez1 1. The University of Michigan Medical School  2. Chiba University Graduate School of Medicine 3. NIAID, NIH

Posters

16.00 ANALYSIS OF THE IMMUNE BARRIER FUNCTION OF THE GASTROINTESTINAL EPITHELIUM OF MOUSE AND HUMAN USING ORGANOIDS AS A MODEL Ozge Kayisoglu1, Nina Wallaschek1, Malvika Pompaiah1, Sina Bartfeld1 1. Research Center for Infectious Diseases (ZINF/IMIB)  17.00 CHARACTERIZING THE HUMORAL IMMUNOLOGICAL MEMORY POPULATIONS INDUCED BY TLR ADJUVANTS Rachel Yuen1, Christina Lisk1, Lee Wetzler1 1. Boston University School Of Medicine  18.00 TLR ADJUVANT INDUCED ALTERATIONS OF GERMINAL CENTER B CELL AND T FOLLICULAR HELPER CELL KINETICS Rachel Yuen1, Christina Lisk1, Lee Wetzler1 1. Boston University School Of Medicine  19.00 THE MOLECULAR BASIS OF THE INNATE RESPONCE TO OLIGOMERS OF BETA AMYLOID AND ALPHA SYNUCLEIN. Craig Hughes1, Lee Hopkins1, Marija Iljina2, Suman Dee2, Francesco Aprile2, David Klenerman2, Clare Bryant1 1. University Of Cambridge, department of veterinary medicine  2. University Of Cambridge, department of Chemistry 20.00 PRR DRIVEN CALCINEURIN-NFAT SIGNALLING IN MESENCHYMAL STEM CELLS Federico Tidu1,2, Kamila Bendickova1, Shyam Jose1, 2, Jan Fric1 1. Center for Translational Medicine (CTM)  2. Masaryk University 21.00 HIGH-MOBILITY GROUP BOX 1 PROTEIN (HMGB1), AN ENDOGENOUS LIGAND OF TOLL-LIKE RECEPTOR, INDUCES ASTROGLIAL INFLAMMATION AND APOPTOSIS Ebtisam Alofi1, Azizah Alrafiah1, Badrah Alghamdi1, Duaa Jabrah1, Sara Jambi1 1. King Abdulaziz University, Jeddah, Saudi Arabia  22.00 A CYTOSOLIC LIPID-BINDING SEQUENCE MEDIATES THE LOCALIZATION OF TLR5 ON THE PLASMA MEMBRANE Jiwon Huh1, Wondae Kang1, Hyunseop Song2, You-Me Kim2 1. Pohang University of Science and Technology  2. Korea Advanced Institute of Science and Technology 23.00 LIGAND RECOGNITION MECHANISM OF TLR7 REVEALED BY A LARGE-SCALE CRYSTALLOGRAPHIC STUDY Zhikuan Zhang1, Umeharu Ohto1, Takuma Shibata1, Ryota Sato1, Kensuke Miyake1, Toshiyuki Shimizu1 1. The University of Tokyo  36

25.00 SYNERGISTIC IMMUNOMODULATORY EFFECTS OF HUMAN MESENCHYMAL STEM CELL EXOSOMES WITH TLR ANTAGONIST A151 ODN Ozlem Bulut1, Sergio Camoes2, Joana Miranda2, Ihsan Gursel1 1. Bilkent University, Ankara, Turkey  2. University of Lisbon, Lisbon, Portugal 26.00 INNATE RECOGNITION AND INFLAMMASOME ACTIVATION IN HUMAN MYELOID IMMUNE CELLS BY METHANOGENIC ARCHAEA Tim Vierbuchen1, Corinna Bang2, Ruth A. Schmitz3, Holger Heine1 1. Research Center Borstel, Kiel, Germany  2. University Hospital Schleswig-Holstein, Kiel, Germany 3. Christian-Albrechts-University, Kiel, Germany 27.00 THE MEK1/2-ERK PATHWAY INHIBITS TYPE I IFN PRODUCTION IN PLASMACYTOID DENDRITIC CELLS Vaclav Janovec1,2,3, Besma Aouar4, Albert Font-Haro1,2,3, Tomas Hofman2, Katerina Trejbalova1, Jan Weber3, Daniel Olive4, Jacques Nunès4 Ruzena Stranska4 Ivan Hirsch1,2,3,4 1. Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague; Czech Republic  2. Faculty of Science, Biocev, Charles University, 12844 Prague, Czech Republic 3. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, IOCB & Gilead Research Center, 16610 Prague, Czech Republic 4. Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, AixMarseille Université UM105, 13273 Marseille, France 28.00 UNRAVELLING BCAP-PI3K SIGNALLING TO UNDERSTAND TOLL-LIKE RECEPTOR REGULATION Johannes Lauenstein1 1. University Of Cambridge  29.00 SPECIFICITY OF INNATE IMMUNE RESPONSES TO LPS IN THE ORAL MUCOSA- CLINICAL CONSEQUENCES Svetislav Zaric1, Alexander Strachan1, Zoe Harrington1, Clare McIlwaine1, Matthew Jerreat1, Aniko Kilar2, Louise Belfield1, Simon Jackson1 Andrew Foey1 1. University Of Plymouth, Peninsula Schools of Medicine And Dentistry  30.00 MODULATION OF INFLAMMATION AND LOCAL INNATE IMMUNE COMPONENTS BY RIFAXIMIN IN A MURINE MODEL OF DSS-INDUCED COLITIS Marina Ferrer1, Vicente Martínez1 1. Universitat Autònoma De Barcelona  37

Posters

24.00 GM-CSF INTRINISCALLY CONTROLS EOSINOPHIL ACCUMULATION IN ALLERGIC AIRWAY INFLAMMATION Samuel Philip Nobs1,2, Merve Kayhan1, Manfred Kopf1 1. ETH Zurich, Zurich, Switzerland  2. Weizmann Institute Of Science, Rehovot, Israel

Posters

31.00 α2, 3-AND α2, 6-SIALYLLACTOSE ENHANCE BACTERIAL CLEARANCE VIA ENDOCYTIC ACTIVITY OF MACROPHAGES IN THE PAK-INDUCED PNEUMONIA MODEL Jimin Kim1,2, Yong-Jae Kim1, Jae Wha Kim1,2 1. Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea  2. University of Science and Technology, Daejeon, Republic of Korea 32.00 TLR4-MEDIATED RESPONSES ARE INHIBITED THROUGH SFK-INDUCED PHOSPHORYLATION BY DISSOCIATING MYD88 AND MAL/TIRAP Su Jin Kim1, Jonathon Mitchell2, Gwangbeom Heo1, Sang Hoon Rhee2, Eunok Im1 1. Pusan National University  2. Oakland University

TYROSINE

33.00 TRANSCRIPTIONAL PROFILES IN ARCHIVED POSTMORTEM TISSUE SAMPLES FROM PATIENTS WITH MENINGOCOCCAL SEPTIC SHOCK Berit Sletbakk Brusletto1,2, Else Marit Løberg3,2, Bernt Christian Hellerud4, Ingeborg Løstegaard Goverud3,2, Åshild Vege5,2, Jens Petter Berg1,2, Unni Gopinathan1,2, Petter Brandtzaeg1,2 Ole Kristoffer Olstad1 Reidun Øvstebø1 1. Department of Medical Biochemistry,Oslo University Hospital, Oslo, Norway  2. Institute of Clinical Medicine, University of Oslo, Oslo, Norway 3. Department of Pathology, Oslo University Hospital, Oslo, Norway 4. Institute of Immunology, Oslo University Hospital, Oslo, Norway 5. Section for Forensic Pediatric Pathology, Department of Forensic Sciences, Oslo University Hospital Oslo; Norway 34.00 ACTIVATION OF TLR2 BY VIBRIO CHOLERAE OMPU INDUCES MAPK MEDIATED PROINFLAMMATORY RESPONSES IN IMMUNE CELLS G. V. R. Krishna Prasad1, Arunika Mukhopadhaya1 1. Indian Institute Of Science Education And Research Mohali  35.00 REGULATION OF TLR SIGNALLING IN MONOCYTES FROM SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS Ryan Thwaites1, Jonathan Smith1, Rekha Parmar2, Frederique Ponchel2, Sandra Sacre1 1. University of Sussex  2. University of Leeds 36.00 A NOVEL TLR4 ANTAGONIST (FP7) REGULATES IN VITRO AND IN VIVO STERILE INFLAMMATION Grisha Pirianov1, Charys Palmer1, Francesco Peri2, Frank Neumann3 1. Anglia Ruskin University, Cambridge, United Kingdom  2. University of Milano-Bicocca, Italy 3. Innaxon, Tewkesbury, United Kingdom

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38.00 TARGETING STING WITH COVALENT SMALL MOLECULE ANTAGONISTS Simone M. Haag1, Muhammet F. Gulen1, Luc Reymond2, Antoine Gibelin2, Laurence Abrami1, Alexiane Decout1, Michael Heymann1, Gisou Van Der Goot1 Gerardo Turcatti2 Rayk Behrendt3 Andrea Ablasser1 1. Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL)  2. Biomolecular Screening Facility, Swiss Federal Institute of Technology Lausanne 3. Institute for Immunology, Faculty of Medicine, Technical University Dresden 39.00 INVESTIGATION OF THERAPEUTIC POTENTIAL OF IMMUNOSUPPRESSIVE A151 ODN LOADED LIPOSOMES IN BLEOMYCIN INDUCED MOUSE SCLERODERMA MODEL Gizem Kilic1, Muzaffer Yildirim1, Ozlem Bulut1, Havva Ozgen Kilgoz1, Banu Bayyurt Kocabas1, Tamer Kahraman1, Gozde Gucluler1, Ihsan Gursel1 1. Bilkent University  40.00 COMPLEMENT C5, TOLL-LIKE RECEPTOR 4, CD14 AND PHAGOCYTOSIS PLAY KEY ROLES IN ESCHERICHIA COLI-INDUCED EXPRESSION OF TISSUE FACTOR ON HUMAN MONOCYTES Anne Landsem1,2, Hilde Fure1, Judith Krey Ludviksen1, Dorte Christiansen1, Grethe Bergseth1, Stig Nymo1, Knut Tore Lappegaard1,2, Terje Espevik3 Tom Eirik Mollnes1,2,3,4 Ole-Lars Brekke1,2 1. Research Laboratory  2. UiT- The ArctisUniversity of Norway, Tromsø, Norway 3. Norwegian University of Science and Technology, Trondheim, Norway 4. Oslo University Hospital Rikshospitalet and University of Oslo, Norway 41.00 PHOSHATIDYLINOSITOL 4-KINASE II-β (PI4KIIβ) IS PALMITOYLATED AND ACTIVATED IN LPSSTIMULATED CELLS TO REGULATE TLR4 SIGNALING AS FOUND USING CLICK CHEMISTRYBASED PROTEOMICS Justyna Sobocińska1, Paula Roszczenko-Jasińska1, Monika Zaręba-Kozioł1, Aneta HromadaJudycka1, Orest Matveichuk1, Gabriela Traczyk1, Katarzyna Kwiatkowska1 1. Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland  42.00 SPHINGOMYELIN AFFECTS TLR4 LEVEL AND LPS-INDUCED CYTOKINE PRODUCTION IN MACROPHAGES Kamila Prymas1, Anna Świątkowska1, Anna Ciesielska1, Ewelina Ziemlińska1, Katarzyna Kwiatkowska1 1. Nencki Institute of Experimental Biology Polish Academy of Sciences 

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37.00 COMPLEXES OF RNA AND THE PSORIASIS-ASSOCIATED ANTIMICROBIAL PEPTIDE, LL37, TRIGGER CYTOKINE AND CHEMOATTRACTANT RELEASE FROM NEUTROPHILS Franziska Herster1, Zsofia Bittner1, David Eisel1, Sabine Dickhöfer1, Markus Löffler1, Dominik Hartl2, Martin Heister3, Kamran Ghoreschi3 Alexander N.R. Weber1 1. Department Of Immunology Tübingen  2. Pediatrics Department, Tübingen 3. Department of Dermatology – Molecular Immunology, Tübingen

Posters

43.00 TOLL-LIKE RECEPTOR 8 SENSES BACTERIA IN HUMAN MONOCYTES AND BLOOD Birgitta Ehrnström1, 2, June F. Kojen 1, Siv Helen Moen1, Jan Kristian Damås1, 2, Tom Eirik Mollnes1, 3, Zhenyi Hu 4, Hang Hubert Yin4, 5, Terje Espevik1 Jørgen Stenvik1, 2 1. Norwegian University of Science and Technology, Trondheim, Norway  2. St. Olavs Hospital HF, Trondheim University Hospital, Trondheim, Norway 3. University of Oslo, Oslo, Norway 4. University of Colorado Boulder, Boulder, Colorado, USA 5. Tsinghua University, Beijing, China 44.00 TLR7 ESCAPE FROM X CHROMOSOME INACTIVATION CONTROLS B-CELL RESPONSES IN WOMEN Mélanie Souyris1, Claire Cenac1, Julie Chaumeil2, José E Mejia1, Jean-Charles Guéry1 1. Centre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France.  2. Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris-Descartes, Paris, France. 45.00 SPATIO-TEMPORAL LOCALIZATION OF TLR2 AND TLR4 RECEPTORS IN PRENATAL DEVELOPMENT OF THE HUMAN RETINA Natalia Nizyaeva1, Rimma Poltavtseva1, Veronica Sinitsyna1, Ina Panova2 1. National Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia  2. N.K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences 46.00 TLR4 SIGNALLING IS REGULATED BY THE ER-RESIDENT TRAFFICKING PROTEIN PROTRUDIN Håvard Lindholm1, Sristy Dangol1, Harald Husebye1, Camilla Raiborg2, Harald Stenmark1, Terje Espevik1, Lene Grøvdal1,2 1. NTNU, Trondheim, Norway  2. University of Oslo, Norway 47.00 HIGH-THROUGHPUT SCREENING OF NANO-INHIBITORS TARGETING TOLL-LIKE RECEPTOR SIGNALING AS NOVEL THERAPEUTICS FOR INFLAMMATORY DISEASES Hong Yang1 1. Shanghai Jiaotong University Affiliated First People’s Hospital  48.00 POLYMORPHISM OF TREM-1 AND TLR GENES AND ITS SIGNIFICANCE IN THE DEVELOPMENT OF A CRITICAL DISEASE AFTER CORONARY ARTERY BYPASS GRAFTING Anastasia Ponasenko1, Maria Khutornaya1, Artem Radivilko1, Anton Kutikhin1, Irina Zhidkova1, Evgeniy Grigoryev1 1. Research Institute for Complex Issues of Cardiovascular Diseases  49.00 MAMMALIAN CELL LINES ENGINEERING FOR STUDYING SPECIFIC TLR2 RESPONSE FOLLOWING SYNTHETIC OR NATURAL LIGANDS INDUCTION Sébastien Desfarges1, Chantal Petit1, Sophie Gauthier1, Arnaud Debin1, Daniel Drocourt1, Jérôme Nigou2, Eric Perouzel1, Michèle Tiraby1 Jean Paul Reynès1 1. InvivoGen, Toulouse, France  2. Pharmacologie et de Biologie Structurale CNRS, Toulouse, France 40

51.00 DIFFERENTIALY REGULATION OF INFLAMMATORY RESPONSES IN MACROPHAGES BY CHLOROQUINE Charlotte Lübow1, Günther Weindl1 1. Institute of Pharmacy (Pharmacology and Toxicology), Freie Universität Berlin  52.00 IDENTIFICATION OF A PYROGALLOL DERIVATIVE AS A POTENT AND SELECTIVE HUMAN TLR2 ANTAGONIST Maria Grabowski1, Manuela S. Murgueitio 2, Marcel Bermudez2, Gerhard Wolber2, Günther Weindl1 1. Institute of Pharmacy (Pharmacology and Toxicology); Freie Universität Berlin  2. Institute of Pharmacy (Pharmaceutical Chemistry); Freie Universität Berlin 53.00 EXPERIMENTAL VALIDATION OF TOLL-LIKE RECEPTOR 8 INHIBITORS IDENTIFIED BY COMPUTATIONAL MODELLING Maria Grabowski1, Dora Šribar2, Manuela S. Murgueitio2, Marcel Bermudez2, Gerhard Wolber2, Günther Weindl1 1. Institute of Pharmacy (Pharmacology and Toxicology); Freie Universität Berlin  2. Institute of Pharmacy (Pharmaceutical Chemistry); Freie Universität Berlin 54.00 INNATE IMMUNE RESPONSES TO TOLL-LIKE RECEPTOR STIMULATION ARE ALTERED DURING THE COURSE OF PREGNANCY Susanne Ziegler1, Cai Niklaas Feldmann1, Sven Hendrik Hagen1, Laura Richert1-4, Virginija Jazbutyte5, Thomas Renné5,6, Kurt Hecher7, Anke Diemert7 Petra Clara Arck7 Marcus Altfeld1 1. Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany  2. Vaccine Research Institute (VRI), Créteil, F-94010, France 3. Université Bordeaux, ISPED, Centre INSERM U1219, Inria, SISTM, Bordeaux, France 4. CHU de Bordeaux, pôle de santé publique, F-33000, Bordeaux, France 5. Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 6. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center HamburgEppendorf, Hamburg, Germany 7. Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital Solna (L1:00), Stockholm, Sweden 55.00 CD5L LIPIDOME REMODELING FUNCTION DEFINES INFLAMMATORY STATE OF HUMAN MACROPHAGES. Neda Nejati Moharrami1, Erlend Tande1, Terje Espevik1, Victor Boyartchuk1 1. CEMIR, Norwegian University of Science and Technology  41

Posters

50.00 RECOGNITION OF MICROBIAL VIABILITY VIA TLR8 DRIVES T FOLLICULAR HELPER CELL DIFFERENTIATION AND VACCINE RESPONSES Matteo Ugolini1, Jenny Gerhard1, Sanne Burkert2, Kristoffer J. Jensen3, Gregers Jungersen3, Ralf R. Schumann2, Leif Erik Sander1 1. Department of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin Berlin, Berlin Germany  2. Institute of Microbiology and Hygiene, Charité – Universitätsmedizin Berlin, Berlin Germany 3. National Veterinary Institute, Technical University of Denmark, Kgs Lyngby, Denmark

Posters

56.00 GENOME-WIDE SCREENING COMBINED WITH AN ITERATIVE BIOINFORMATIC ANALYSIS MODEL IDENTIFIES CRITICAL ROLES FOR PROTEIN DEGRADATION AND ALTERNATIVE SPLICING IN TLR-INDUCED MACROPHAGE ACTIVATION Samuel Katz1, Jing Sun1, Jian Song1, Jospeh Gillen1, Nicolas Lounsbury1, Aleksandra Nita-Lazar1, Clare Bryant2, Iain Fraser1 1. National Institutes of Health  2. University of Cambridge 57.00 TLR9 MODULATES HOST DEFENSE VIA REGULATING B CELL RECRUITMENT AND IGM PRODUCTION DURING SEPSIS Meihong Deng1, Li Xu1, Rosemary Hoffmann1, Timothy Billiar1 1. University of Pittsburgh  58.00 THE TRANSLATION OF NON-CANONICAL OPEN READING FRAMES FACILITATES MUCOSAL IMMUNITY Ruaidhri Jackson1, Will Bailis1, Lina Kroehling1, Abigail Jarret1, Omair Khan1, Autumn York1, Angel Solis1, Alexandra Khitun1 Sarah Slavoff1 Richard Flavell1 1. Yale University  59.00 ACTIVATION OF THE TLR4 SIGNALLING COMPLEX BY THE EBOLA VIRUS GLYCOPROTEIN Michael Scherm1, Olaniyi Opaleye1, Nick Gay1 1. University Of Cambridge  60.00 IMMUNE ACTIVATION BY PARTICULATE MATTER AIR POLLUTION Victoria M. Cevallos1, Valeria Díaz1, 2, Cherilyn M. Sirois1, 3, 4 1. Universidad de Las Américas, Quito, Ecuador  2. Secretariat of the Environment, Quito, Ecuador 3. Universidad Tecnológica Equinoccial, Quito, Ecuador 4. Springfield College, Springfield, Massachusetts, United States 61.00 ANALYSIS OF TRIF (TOLL/INTERLEUKIN-1 RECEPTOR [TIR]-DOMAIN-CONTAINING ADAPTORINDUCING INTERFERON-ß) OLIGERMIC STRUCTURES James Linyard1, Brett Verstak2, Nick Gay1 1. University of Cambridge, Cambridge, United Kingdom  2. Abzena, Cambridge, United Kingdom 62.00 SYNTHETIC FLUX OF MONO-UNSATURATED FATTY ACIDS IS REQUIRED TO NEGATIVELY REGULATE INFLAMMATION Autumn York1, 2, 3, Quan Zhou2, Kevin Williams2, Philip Scumpia2, Stephen Smale2, Richard Flavell1, 3 , Steven Bensinger2 1. Yale University  2. University of California, Los Angeles 3. Howard Hughes Medical Institute 42

64.00 A NEW POTENT ADJUVANT / IMMUNOMODULATORY PROTEIN OF TRYPANOSOMA CRUZI ACTS THROUGHT TLR2 AND TLR4 Sarra Ait Djebbara1, Pauline Lehebel1, 2, Véronique Flamand3, Noria Segueni1, Carine Truyens1 1. Universite libre de Bruxelles, Brussels, Belgium  2. Scientific Institute of Public Health, Brussels, Belgium 3. Université libre de Bruxelles, Gosselies, Belgium 65.00 LEISHMANIA AMAZONENSIS SABOTAGE MACROPHAGE SUMO SKILLS FOR INTRACELLULAR PROLIFERATION Kendi Okuda1, Sara Cherry2, Neal Silverman1 1. Department of Medicine University of Massachusetts Medical School, Worcester, USA 2. Department of Microbiology University of Pennsylvania, Philadelphia, USA 66.00 GENOME-WIDE ANALYSIS OF H3K27AC AND PU.1 BINDING PATTERNS IN HUMAN NEUTROPHILS ACTIVATED VIA TLR8 Nicola Tamassia1, Francisco Bianchetto-Aguilera1, Sara Gasperini1, Sara Polletti2, Gioacchino Natoli2, Marco Antonio Cassatella1 1. University of Verona, Verona, Italy  2. Humanitas University, Rozzano, Milan, Italy 67.00 IDENTIFICATION OF NOVEL STAT1/P65 BINDING MULTI-GENE ENHANCERS IN IMMEDIATEEARLY PRO-INFLAMMATORY GENE EXPRESSION Anna Piaszyk-Borychowska1, Joanna Wesoły1, Hans Bluyssen1 1. Adam Mickiewicz University, Poznań, Poland  68.00 FASL PROMOTES AN INDUCIBLE TLR-DEPENDENT MODEL OF CUTANEOUS LUPUS-LIKE INFLAMMATION Purvi Mande1, Bahar Zirak2, Wei-Ko Che1, April Deng1, Rachel Ettinger3, Katherine A. Fitzgerald1, Michael Rosenblum2, John E. Harris1, Ann Marshak-Rothstein1 1. University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA. 2. UCSF School of Medicine, San Francisco, CA 94143, USA. 3. Respiratory, Autoimmunity, and Inflammation Department, MedImmune LLC, Gaithersburg, Maryland 20878, USA.

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Posters

63.00 TOLL-LIKE RECEPTOR 4 EVADING DETECTION: DETECTION OF TLR4 USING ADVANCED PROTEOMICS STUDIES Sanam Mustafa1, Chris Ashwood2, Nicki Packer2, Mark Hutchinson1 1. University of Adelaide  2. University of Macquarie

Posters

69.00 CLASS I  PI3Kα AND PI3Kδ ISOFORMS DIFFERENTIALLY REGULATE PRR SIGNALLING IN INTESTINAL EPITHELIAL CELLS AND CONTROL GUT HOMEOSTASIS AND HEALTH Laura Medrano Gonzalez1, Maria Gonzalez-Nunez1, Esther Castellano1, Ezra Aksoy1 1. Queen Mary University of London, London, United Kingdom  70.00 ANTIBIOTIC TREATMENT-INDUCED SECONDARY IGA-DEFICIENCY ENHANCES SUSCEPTIBILITY TO PSEUDOMONAS AERUGINOSA PNEUMONIA Catherine Chaput1, Oliver Robak1,2, Andrey Kruglov3, Sandra Prepens1, H. Hochrein4, C. J. Kirschning5, U. Steinhoff7, Leif Sander1,6 Markus Heimesaat1 Bastian Opitz1,6 1. Charite Medicin-University  2. Medical University of Vienna, Vienna, Austria 3. German Rheumatism Research Center, Berlin, Germany 4. Bavarian Nordic GmbH, Martinsried, Germany 5. Institute of Medical Microbiology, University of Duisburg-Essen, Essen Germany 6. German Center for Lung Research (DZL) 7. Institute for Medical Microbiology and Hygiene - University of Marburg, Marburg, Germany 71.00 CROSSTALK OF HUMAN TLR2 AND TLR8-IRF5 SIGNALING Siv Helen Moen1, June Frengen Kojen1, Birgitta Ehrnström1,2, Jan Kristian Damås1,2, Terje Espevik1, Jørgen Stenvik1,2 1. Norwegian University of Science and Technology, Trondheim, Norway  2. St. Olavs Hospital HF, Trondheim University Hospital, Trondheim, Norway 72.00 MODULATION OF MACROPHAGES ACTIVITY AND TLRS EXPRESSION BY OXIDIZED PHOSPHOLIPIDS DERIVED FROM PULMONARY LIQUID SURFACTANT Carlos Sorgi1,2, Luma Loureiro2, Luana Loureiro2, Edson Gabriel-Junior1, Lucia Faccioli1 1. Universidade De Sao Paulo (USP), Ribeirão Preto/ SP - Brazil  2. Universidade Federal do Amazonas (UFAM), Manaus/ AM - Brazil 73.00 D-ALANYLATION OF TEICHOIC ACIDS IN STAPHYLOCOCCUS AUREUS PREVENTS IMMUNE ACTIVATION OF MACROPHAGES Helene Skovsted1, Hanne Frøkiær1 3. University of Copenhagen  74.00 CAGED TLR2 LIGANDS CAN BE CONDITIONALLY CONTROLLED TO STUDY THE DYNAMICS OF TLR SIGNALING Timo Oosenbrug1, Michel J. van de Graaff2, Rob C. Hoeben1, Jacques J.C. Neefjes1, Maaike E. Ressing1, Sander I. van Kasteren2 1. Leiden University Medical Center, Leiden, The Netherlands  2. Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

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77.00 DEVELOPMENT OF NOVEL TLR4 ANTAGONISTS Joe Boyle1, Krzysztof Kolmus1, Nick Gay1, Clare Bryant1 1. University Of Cambridge  78.00 P38/MK2 PHOSPHORYLATES RIPK1 TO LIMIT CYTOTOXIC RIPK1 SIGNALING IN BACTERIAINFECTED MACROPHAGES Julia Gropengießer1, Lena Novikova1, Hanna Schimmeck1, Nicole Czymmeck1, Klaus Ruckdeschel1 1. Institute for Microbiology, University Medical Center Eppendorf  79.00 HEART TOLL-LIKE RECEPTOR 2 RECOGNIZE SCORPION VENOM AND CONTRIBUTES TO IL-1β PRODUCTION Mouzarllem Reis, Carlos Sorgi, Alyne Meirelles, Lúcia Faccioli 1. Universidade De São Paulo  80.00 MICROBIAL LIPID A MODIFICATIONS REGULATE DENDRITIC CELL FUNCTION AND DEVELOPMENT OF HOST IMMUNITY Caroline Genco2, George Papadopoulos1,2, Robert Berland2, Ashwini Sunkavalli2, Richard Darveau3, Stephen Coats3 1. Boston University School of Medicine  2. Tufts University School of Medicine 3. University of Washington, Seattle 81.00 SYNERGISTIC EFFECT OF EGFR/MEK INHIBITORS AND PROPIONIBACTERIUM ACNES IN THE INDUCTION OF IL-36G-MEDIATED CUTANEOUS INFLAMMATION Takashi Satoh1, Mark Mellett1, Barbara Meier1, Gabriele Fenini1, Atsushi Otsuka2, Emmanuel Contassot1, Lars French1 1. University of Zurich  2. Kyoto University 82.00 CHARACTERIZATION OF NATURALLY OCCURRING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE TOLL-LIKE-RECEPTOR 3 GENE Jasper Hesebeck-Brinckmann1, Ombretta Colasanti1, Volker Lohmann1 1. University of Heidelberg 

45

Posters

75.00 FUNGAL CHITIN RECOGNITION IN MAMMALS IS BASED ON OLIGOMER SIZE AND TLR2 Yamel Cardona Gloria1, Katharina Fuchs1, Olaf-Oliver Wolz1, Franziska Herster1, Lokesh Sharma2, Carly Dillen3, Christoph Täumer1, Sabine Dickhöfer1 Zsofia Bittner1 Alexaner N.R. Weber1 1. University of Tübingen, Tübingen, Germany  2. Center for Pulmonary Infection Research and Infection, New Haven, USA 3. Johns Hopkins University School of Medicine, Baltimore, USA

Posters

83.00 EXPRESSION OF TLRS AND INFLAMMATORY CYTOKINES IN DENTAL PULP TISSUE ASSOCIATED WITH DEEP CARIOUS LESIONS Ana Pamela Gómez-García1, Alma Reyna Escalona-Montaño1, Miriam Nieves-Ramírez 1, Yolanda López-Vidal1, María Magdalena Aguirre-García1 1. Unam  84.00 TMED PROTEINS AND THEIR ROLE IN THE TRANSPORT OF TOLL- LIKE RECEPTORS FROM ER TO GOLGI Julia Holm1, Nicholas Gay 1, Sandro Soares 2 1. University of Cambridge, Cambridge, United Kingdom  2. Universidade de São Paulo, São Paulo, Brazil 85.00 THE IkB-PROTEIN BCL-3 CONTROLS THE CELLULAR DECISION TO REPOND TO TOLL-LIKE RECEPTOR ACTIVATION BY REGULATING MAPK AND NF-ĸB ACTIVITY IN THE NUCLEUS Ruaidhri Carmody1, Patricia Collins1, Felicity Herrington1, Domenico Somma1, Robert Nibbs1 1. University Of Glasgow  86.00 TLR3 EXPRESSION IN THE TERM PLACENTA INFECTED WITH HUMAN CYTOMEGALOVIRUS Agnieszka Jabłońska1, Mirosława Studzińska1, Jarosław Kalinka2, Patrycja Stańczyk2, Edyta Paradowska1 1. Institute of Medical Biology of The Polish Academy of Sciences, Lodz, Poland  2. Medical University of Lodz, Poland 87.00 SURFACE TOLL-LIKE RECEPTOR 3 EXPRESSION IN METASTATIC INTESTINAL EPITHELIAL CELLS INDUCES INFLAMMATORY CYTOKINE PRODUCTION AND PROMOTES INVASIVENESS Marit Bugge1,2, Bjarte Bergstrom1, Oda K Eide1, Helene Solli1, Ingrid F. Kjønstad1, Jørgen Stenvik1, Terje Espevik1, Nadra J. Nilsen1,2 1. Norwegian University of Science and Technology, Trondheim, Norway  2. St Olav’s University Hospital, Trondheim, Norway 88.00 IRAK4 KINASE INHIBITORS: THE PHARMACOLOGY OF BLOCKING TOLL/IL1 SIGNALING Vikram Rao1, Saurav De1, Aaron Winkler1, Katherine Lee1, Leah Cushing1, Scott Jelinsky1, Ken Dower1, Weiyong Sun1 Andrea Bree1 Martin Hegen1 1. Pfizer Inc  89.00 TLR9 -1237T/C AND 2848C/T POLYMORPHISMS ARE ASSOCIATED WITH THE RISK OF HIV/ CMV CO-INFECTION Agnieszka Jabłońska 1, Mirosława Studzińska1, Elżbieta Jabłonowska2, Juliusz Kamerys2, Dorota Nowakowska3, Zuzanna Gaj3, Jan WilczyńSki4, Edyta Paradowska1 1. Institute of Medical Biology of The Polish Academy of Sciences, Lodz, Poland  2. Medical University in Lodz, Poland 3. Polish Mother’s Memorial Hospital Research Institute, Lodz, Poland 4. Warsaw Medical University, Poland 46

91.00 THE SIMULTANEOUS BINDING OF TWO DNA MOTIFS FOR EFFICIENT ACTIVATION OF TLR9 REVEALED BY X-RAY CRYSTALLOGRAPHY Umeharu Ohto1, Hanako Ishida1, Takuma Shibata1, Ryota Sato1, Kensuke Miyake1, Toshiyuki Shimizu1 1. University Of Tokyo  92.00 TOLL-LIKE RECEPTOR GENE POLYMORPHISMS IN CHILDREN AND ADOLESCENTS WITH INFECTIOUS MONONUCLEOSIS Agnieszka Jabłońska1, Mirosława Studzińska1, Leszek Szenborn2, Monika Karlikowska-Skwarnik2, Małgorzata Wiśniewska-Ligier3, Tomasz Gęsicki3, Zbigniew J. Leśnikowski1, Edyta Paradowska1 1. Institute of Medical Biology of The Polish Academy of Sciences, Lodz, Poland  2. Wroclaw Medical University, Wroclaw, Poland 3. Polish Mother’s Memorial Hospital Research Institute, Lodz, Poland 93.00 INDUCTION OF TLR2-DEPENDENT COMMON ANTI-VIRAL IMMUNE RESPONSES BY REPEATING PROTEIN SUBUNIT ASSEMBLIES Agnieszka Rynda-Apple1, Kelly Shepardson1, Benjamin Schwartz2,3, Trevor Douglas2, Kyle Larson1, Laura Johns1, John Avera2 1. Montana State University, Bozeman, Montana, USA  2. Indiana University, Bloomington, Indiana, USA 3. National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA 94.00 GUANOSINE SENSING BY TLR7 AND ITS IMPLICATION IN INFLAMMATORY DISEASE Takuma Shibata1,4, Masato Taoka2, Umeharu Ohto3, Zhikuan Zhang3, Shin-Ichiroh Saitoh1, Yuji Motoi1, Toshiaki Isobe2, Toshiyuki Shimizu3,4 Kensuke Miyake1 1. The Institute of Medical Science, The University of Tokyo  2. Graduate School of Science and Technology, Tokyo Metropolitan University 3. Graduate School of Pharmaceutical Sciences, The University of Tokyo 4. CREST, Japan Science and Technology agency 96.00 NOD2 INTERVENES COLORECTAL TUMORIGENESIS VIA SUPPRESSION OF THE TLR PATHWAYS Hasan Zaki1 1. UT Southwestern Medical Center  97.00 A NOVEL TERMINAL URIDYLTRANSFERASE REGULATES TLR4-DRIVEN INFLAMMATORY RESPONSES Li-Chung Hsu1, Chia-Ching Lin1, Yi-Ru Shen1, Chi-Chih Chang1, Yun-Yun Yang1, Xiang-Yi Guo1 1. National Taiwan University 

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90.00 INVOLVEMENT OF NON-CANONICAL AUTOPHAGY IN RESPONSE TO BORRELIA BURGDORFERI Bijaya Sharma1 1. Tufts University 

Posters

98.00 DUPLICATED TLR5 OF ZEBRAFISH FUNCTIONS AS A HETERODIMERIC RECEPTOR Carlos Voogdt1, Jaap Wagenaar1, Jos van Putten1 1. Utrecht University  100.00 DIFFERENTIAL REGULATION OF THE TRANSCRIPTOMIC AND SECRETOMIC LANDSCAPE OF SENSOR AND EFFECTOR FUNCTIONS OF HUMAN AIRWAY EPITHELIAL CELLS Lehmann R1, Müller MM1,2, Klassert TE1, Driesch D3, Stock M1, Heinrich A1, Conrad T1,4, Moore C1 Schier UK1 Guthke R4 Slevogt H1 1. Septomics Research Centre, Jena University Hospital, Jena, Germany  2. Integrated Research and Treatment Centre - Centre for Sepsis Control and Care (CSCC), Jena 3. University Hospital, Jena, Germany 3. BioControl Jena GmbH, Jena, Germany 4. Research Group Systems Biology and Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany 101.00 FUNCTIONAL ANNOTATION OF MEMBRANE LIPIDS IN TLR BIOLOGY Leonhard Heinz1, Berend Snijder1, Marielle Köberlin1, Giulio Superti-Furga1 1. CeMM Research Center for Molecular Medicine of The Austrian Academy Of Sciences  103.00 TLR3 IS A NEGATIVE REGULATOR OF IMMUNE RESPONSES AGAINST PARACOCCIDIOIDES BRASILIENSIS Karen Ferreira1, Grasielle Jannuzzi2, José Almeida2, Gustavo Amarante-Mendes2, Lavinia Romera2, Gilberto Kaihami2, José Vasconcelos1, Camila Ferreira1, Sandro Almeida2 1. UNIFESP  2. USP 104.00 INTRATUMORAL IMMUNOTHERAPY WITH TLR7/8 AGONIST MEDI9197 MODULATES THE TUMOR MICROENVIRONMENT LEADING TO ENHANCED ACTIVITY WHEN COMBINED WITH OTHER IMMUNOTHERAPIES Stefanie Mullins1, John Vasilakos2, Katharina Deschler1, Iwen Grigsby2, Song Ren3, Matthew Elder1, Simon Dovedi1, Andrew Leishman1 Patricia Ryan3 Zachary Cooper3 James Elvecrog2 Ronald Herbst Rakesh Kumar Mark Tomai Robert Wilkinson 1. MedImmune Ltd, Cambridge, UK  2. 3M, St. Paul, MN, USA 3. MedImmune LLC, Gaithersburg, MD, USA 105.00 MODULATION OF TLR4 SIGNALING AND CASPASE-4/11 ACTIVATION WITH SYNTHETIC SUGARS Alla Zamyatina1, Holger Heine2, Rudi Beyaert3, Feng Shao4 1. University of Natural Resources and Life Sciences  2. Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany 3. Center for Inflammation Research, VIB, Ghent University, Ghent, Belgium 4. National Institute of Biological Sciences, Beijing, China

48

Posters

106.00 STRUCTURAL STUDIES OF THE NS1-TLR4 COMPLEX Olaniyi Opaleye1, Nicholas J. Gay1 1. University Of Cambridge  107.00 SATURATED CARDIOLIPINS ACTIVATE TLR4: A MECHANISTIC BASIS FOR INFLAMMATION IN BARTH SYNDROME Malvina Pizzuto1, 2, Caroline Lonez2, Monique Gangloff3, Pani Tourlomousis3, Jean-Marie Ruysschaert2, Nick J Gay3, Clare E Bryant3 1. Biomedical Research Institute of Murcia (IMIB-Arrixaca),  2. Université Libre de Bruxelles, Brussels, Belgium 3. University of Cambridge, Cambridge, United Kingdom   108.00 SYMBIONT-ASSOCIATED MOLECULAR PATTERNS DIRECT TOLEROGENIC RESPONSES VIA MULTIPLE PATHWAYS Deniz Erturk-Hasdemir1, Sungwhan Oh1,2, Nihal Okan 1, Giuseppe Stefanetti1, Francesca Gazzaniga1, Peter Seeberger3,4, Scott Plevy5, Dennis Kasper 1 1. Harvard Medical School, Boston, MA 02115, USA  2. Brigham and Women’s Hospital, Boston, MA 02115, USA 3. Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany 4. Free University Berlin, 14195 Berlin, Germany 5. Janssen Research and Development, LLC, Spring House, PA, USA

INTERFERON SIGNALING 109.00 TYPE III INTERFERONS REGULATE INTESTINAL INFLAMMATION Ivan Zanoni1, Achille Broggi1, Francesca Granucci2 1. Harvard Medical School  2. University of Milano-Bicocca 110.00 A MUTATIONAL STUDY OF IRF3 REVEALS DIFFERENCES OF IRF3 ACTIVATION BY MAVS, STING AND TRIF Louise Marie Kragh Dalskov1, Line Lykke Andersen2, Ryo Narita1, Hans Henrik Gad1, Kennith Hudtloff Kristensen1, Jacob Giehm Mikkelsen1, Trine Hyrup Mogensen1, Rune Hartmann1 1. Aarhus University, Aarhus, Denmark  2. Max Planck Institute of Biochemistry, Munich, Germany 111.00 THE TLR4 ADAPTOR TRAM CONTROLS PHAGOCYTOSIS OF GRAM-NEGATIVE BACTERIA THROUGH TRAM AND THE RAB11-FAMILY INTERACTING PROTEIN 2 Harald Husebye1, Astrid Skjesol1, Mariia Yurchenko1, Lene Melsæther Grøvdal1, Giuseppe Teti2, Korbinian Bösl1, Bjørnar Sporsheim1, Richard Kumaran Kandasamy1 Mary McCaffrey3 Terje Espevik1 1. Norwegian University of Science and Technology, Trondheim, Norway  2. University of Messina, Messina, Italy 3. University College Cork, Cork, Ireland 49

Posters

112.00 REVISITING THE INTERFEROME Mario Santiago7, Kejun Guo1, Jon Kibbie2, Tania Gonzalez3, Stephanie Dillon4, Martin McCarter5, Cara Wilson6 1. University of Colorado  113.00 MYCOBACTERIUM TUBERCULOSIS ESAT6 INDUCES IFN-β MACROPHAGES VIA TLRS-MEDIATED SIGNALING Ah-Ra Jang1, Joo-Hee Choi1, Sung Jae Shin2, Jong-Hwan Park1 1. Chonnam National University, Gwangju, Republic of Korea  2. Yonsei University College of Medicine, Seoul, Republic of Korea

GENE

EXPRESSION

IN

114.00 INFLUENZA VACCINATION INDUCES NK CELL MEDIATED TYPE-II IFN RESPONSE THAT REGULATES HUMORAL IMMUNITY IN AN IL-6 DEPENDENT MANNER Yagmur Farsakoglu1, 2, Miguel Palomino-Segura1, 2, Silvia Zanaga1, Nikolaos Chatziandreou1, Diego Ulisse Pizzagalli1, 3, Federica Sallusto1, 4, Jens Stein5, Santiago F. Gonzalez1 1. Institute for Research In Biomedicine  2. Graduate School of Cellular and Molecular Sciences, University of Bern 3. Institute of Computational Science (ICS), Università della Svizzera italiana. 4. Institute for Microbiology, ETH Zurich 5. Theodor Kocher Institute (TKI), University of Bern 115.00 RECIPROCAL REGULATION OF STING AND TCR SIGNALING BY MTORC1 FOR T CELL ACTIVATION AND FUNCTIONS Takayuki Imanishi1, Takashi Saito1 1. RIKEN Center for Integrative Medical Sciences (IMS)  116.00 DNA DAMAGE ACTIVATES AN EARLY INNATE IMMUNE RESPONSE IN HUMAN CELLS DEPENDENT ON NON-CANONICAL STING ACTIVATION Gillian Dunphy1, Dympna J. Connolly2, Kasper L. Jønsson3, Martin R. Jakobsen3, Andrew G. Bowie2, Leonie Unterholzner1 1. Lancaster University, Lancaster, United Kingdom  2. Trinity Biomedical Sciences Institute, Dublin, Ireland 3. Aarhus University, Aarhus, Denmark 117.00 THE ROLE OF CELL FREE FETAL DNA AND DNA-RECOGNITION RECEPTORS EXPRESSION IN EARLY-ONSET PREECLAMPSIA N.V.Nizyaeva 1, A.O.Karapetian, А.А.Sadekova, A.M.Krasniy, G.V.Khlestova, O.R. Baev 1. National Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow

50

119.00 HUMAN PLASMACYTOID DENDRITIC CELLS SENSE DSDNA VIA THE CGAS-STING SIGNALING PATHWAY Folkert Steinhagen1, Mario Fox1, Poonam Tewary2, Dennis Klinman3, Christian Bode1 1. University Hospital Bonn, Germany  2. Leidos Biomedical Research Inc, FNLCR, Frederick, MD, USA 3. Center for Cancer Research, NCI, Frederick, MD, USA 120.00 SUPPRESSIVE OLIGODEOXYNUCLEOTIDES INHIBIT THE CYTOSOLIC DNA SENSING PATHWAY CGAS-STING Christian Bode1, Thomas Zillinger2, Mario Fox1, Dennis Klinman3, Folkert Steinhagen1 1. University Hospital Bonn  2. Center for Cancer Research/NCI 3. University Hospital Bonn 121.00 MACROPHAGES AND NOT CONVENTIONAL DENDRITIC CELLS ARE THE PRIMARY IFN-β SOURCE IN RESPONSE TO GROUP B STREPTOCOCCUS Nuria Elias Perdigo1, Reinhild Feuerstein1, Sebastian Baasch1, Philipp Henneke1,2 1. Center For Chronic Immunodeficiency, University Medical Center, Freiburg  2. Center for Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany 122.00 CHARACTERIZATION OF IRF1 AND IRF8 TRANSCRIPTIONAL NETWORKS IN VASCULAR INFLAMMATION AND IDENTIFICATION OF FUNCTIONAL INHIBITORS. Aleksandra Antończyk1, Małgorzata Szeląg1, Anna Piaszyk-Borychowska1, Joanna Wesoły1, Hans Bluyssen1 1. Adam Mickiewicz University, Poznan, Poland  123.00 INTERFERON TARGETING BY ENTERIC BACTERIA Andrew Voak1, Shayla Venkaya1, Kyle Frowde1, Charlotte Odendall1 1. King’s College London  124.00 GENETIC CAUSES AND NEW THERAPEUTIC APPROACH IN MONOGENIC SYSTEMIC LUPUS ERYTHEMATHOSUS Christine Wolf1, Constanze Griep1, Michael Kirschfink2, Normi Brück1, Katharina Palm-Beden3, Stefan Winkler1, Victoria Tüngler1, Reinhard Berner1 Claudia Günther1 Min Ae Lee-Kirsch1 1. Universitätsklinikum Dresden  2. Universitätsklinikum Heidelberg 3. St. Josef-Stift Sendenhorst

51

Posters

118.00 LEUKOTRIENE B4 – TYPE I INTERFERON AXIS REGULATES MACROPHAGE-MEDIATED HOST TOLERANCE TO INFLUENZA INFECTION Erwan Pernet1, Jeffrey Downey1, Maziar Divangahi1 1. McGill University, Montreal, Québec, Canada 

Posters

125.00 REGULATION OF IRG1 IN PRIMARY IMMUNODEFICIENCY SYNDROMES Katelyn McCann1,2, Amy Hsu1, Alexandra Freeman1, Elizabeth Sampaio1, Beth McCormick2, Steven Holland1 1. NIAID, NIH, Bethesda, MD, USA  2. University of Massachusetts Medical School, Worcester, MA, USA 126.00 REGULATION OF DENDRITIC CELL ACTIVATION BY CHECKPOINT INHIBITORS Meredith O’Keeffe1, Christophe Macri1, Benjamin Fancke2, Ee Shan Pang1, Joanne Pooley1, Timothy Patton1, Daniel Gray3, Hubertus Hochrein4 1. Monash University  2. Peter MacCallum Cancer Centre 3. WEHI 4. Bavarian-Nordic GmbH 127.00 REGULATION OF TLR9-INITIATED TYPE I IFN PRODUCTION IN HUMAN PLASMACYTOID DENDRITIC CELLS Katarzyna Grzes1, Edward Pearce1,2 1. MPI Freiburg  2. University of Freiburg   128.00 AUTOPHAGY COUNTERS INFLAMMATORY CYTOKINE-INDUCED MACROPHAGE CELL DEATH AND PROMOTES SURVIVAL DURING THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME. Anthony Orvedahl1, Michael McAllaster1, Chandni Desai1, Ya-Ting Wang1, Dale Balce1, Robert Orchard1, Scott Handley1, Max Artyomov1 John Doench2 Herbert Virgin1 1. Washington University, St. Louis, Missouri, USA  2. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA 129.00 TYPE I INTERFERON SIGNALING PATWAY IS INCREASED IN BREAST CANCER PATIENTS WITH GOOD PROGNOSIS TUMORS Maria Clavijo-Salomon1,2, Adilson Kleber Ferreira1, Roger Chammas2 1. Institute of Biomedical Sciences, University of São Paulo, Sao Paulo, SP, Brazil  2. Institute of Cancer of Sao Paulo, University of São Paulo Medical School, Sao Paulo, SP, Brazil

ANTIVIRAL SIGNALING 130.00 NRF2 IS A NEGATIVE REGULATOR OF STING DURING METABOLIC REPROGRAMMING David Olagnier1, Aske M. Brandtoft1, Camilla Gunderstofte1, Nikolaj L. Villadsen1, Christian Krapp1, Anne L. Thielke1, Anders Laustsen1, Suraj Peri2 Anne-Louise Hansen1 Lene Bonefeld1 1. Aarhus University, Aarhus, Denmark  2. Fox Chase Cancer Center, Philadelphia, USA

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132.00 CGAS IS ACTIVATED BY DNA IN A LENGTH-DEPENDENT MANNER Stefanie Luecke1, Andreas Holleufer1, Maria Christensen1, Kasper Jønsson1, Gerardo Boni1, Lambert Sørensen2, Mogens Johannsen2, Martin Jakobsen1, Rune Hartmann1, Søren Paludan1 1. Aarhus University  2. Aarhus University Hospital 133.00 PROTEIN GERANYLGERANYLATION LICENSES RHO GTPASES-INHIBITION OF MAVS SIGNALING Donghai Wang1, Shigao Yang1, Alfred Harding2, Catherine Sweeney1, David Miao1, Connie Zhou1, Zhaozhao Jiang3, Katherine Fitzgerald3 Gianna Hammer4 Martin Bergo5 1. Duke University School of Medicine  2. Duke University School of Medicine 3. UMASS Medical School 4. Duke University School of Medicine MGM 5. Karolinska Institute 6. Vanderbilt University School of Medicine 7. University of Toronto 134.00 NRF2 INCREASES SUSCEPTIBILITY TO HSV INFECTION BY IMPAIRING THE ANTIVIRAL INNATE IMMUNE RESPONSE Camilla Gunderstofte1, Marie B. Iversen1, Christian K. Holm1, David Olagnier1 1. Aarhus University, Biomedicine Department, Aarhus C, 8000, Denmark  135.00 THE STUDY OF ROLE P204 IN SENSING OF MOUSE POLYOMAVIRUS GENOMES IN THE MOUSE FIBROBLASTS Sandra Huerfano1, Vojtech Shroller1, Irina Soldatova1, Jitka Forstova1 1. Charles University  136.00 POTENT AND SELECTIVE INHIBITION OF MERS CORONAVIRUS PAPAIN-LIKE PROTEASE BY ENGINEERED UBIQUITIN VARIANTS Marjolein Kikkert1, Robert Knaap1, Wei Zhang2, Ben Bailey-Elkin3, Brian Mark3, Sachdev Sidhu2 1. Leiden University Medical Center, Leiden, ZH, Netherlands  2. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, University of Manitoba, Mannitoba, Winnipeg, Canada

53

Posters

131.00 SIGN-R1-DEPENDENT RECOGNITION OF INFLUENZA BY INFLAMMATORY DC CONTRIBUTE TO THE REDUCTION OF VIRUS LEVELS IN THE TRACHEA BY PROMOTING RECRUITMENT AND ACTIVATION OF NK CELLS. Miguel Palomino Segura1, Yagmur Farsakoglu1, Tommaso Virgilio1, Rocco D’Antuono1, Diego Ulisse Pizzagalli1,2, Nikolaos Chatziandreou1, Laureant Perez1, Santiago Fernandez Gonzalez1 1. Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.  2. Institute of Computational Science, Università della Svizzera italiana, Lugano, Switzerland.

Posters

137.00 POXVIRUSES PREVENT STING ACTIVATION TO EVADE CELLULAR INNATE IMMUNITY Iliana Georgana1, Rebecca Sumner2, Greg Towers2, Carlos Maluquer de Motes1 1. University of Surrey, Guildford, United Kingdom  2. University College London, London, United Kingdom 138.00 SECONDARY INFECTION WITH MRSA AFTER INFLUENZA A VIRUS INFECTION Victor Bruun1, Jacob Thyrsted Jensen1, Christian Kanstrup Holm1 1. Department Of Biomedicine  139.00 STRUCTURAL BASIS OF VIRAL DOUBLE-STRANDED RNA RECOGNITION BY MDA5 Qin Yu1, Kun Qu2, Yorgo Modis1 1. University of Cambridge / MRC Laboratory of Molecular Biology, Cambridge, U.K.  2. MRC Laboratory of Molecular Biology, Cambridge, U.K. 140.00 A DNA-SENSING-INDEPENDENT ROLE OF A NUCLEAR RNA HELICASE, DHX9 IN INNATE IMMUNITY AGAINST DNA VIRUSES Yee Ching Ng1, Woo-Chang Cheong1, Hye-ri Kang1, Hye Jeong Cho1, Eun-Byeol Park2, Suk-Jo Kang2, Moon Jung Song1 1. Korea University  2. Korea Advanced Institute of Science and Technology 141.00 THE MOONLIGHTING PROTEIN 14-3-3ƞ PLAYS AN ESSENTIAL ROLE IN MDA5-DEPENDENT ANTI-VIRAL SIGNALING PATHWAY Jih-Pu Lin1, Helene Minyi Liu1 1. National Taiwan University/Institution of Biochemistry and Molecular Biology  142.00 MITOCHONDRIA DYNAMICS REGULATING THE STING-MEDIATED DNA SENSING PATHWAY Suk-Jo Kang1, Dohyeong Kwon1, Eunbyeol Park1, Hiromi Sesaki2 1. Korea Advanced Institute of Science and Technology  2. Johns Hopkins University School of Medicine 143.00 PERSISTENT REPLICATION OF HIV, HCV AND HBV RESULTS IN DISTINCT GENE EXPRESSION PROFILES BY HUMAN NK CELLS Lauke Boeijen1, Jun Hou1, Rik de Groen1, Annelies Verbon1, Andre Boonstra1 1. Erasmus Mc  146.00 TRIM9 AND ITS DICHOTOMOUS PROVIRAL FUNCTION IN INNATE IMMUNITY Dharmendra Pandey1, Hanna Nowotny1, Johannes Rueckel1, Jannis Tossounidis1, Sophia Anton1, Hanaa Gaber2, Ulrike Protzer2, Stefan Endres1 Simon Rothenfusser1 1. Department of Clinical Pharmacology, Department Of Medicine IV, Ludwig-Maximilian University Of Munich, Munich, Germany  2. Institute of Virology, Technische Universität München and Helmholtz Zentrum München, Munich, Germany 54

148.00 THE CGAS-STING PATHWAY IN DROSOPHILA MELANOGASTER Andreas Holleufer1, Bine Simonsen1, Jean-Luc Imler2, Rune Hartmann1 1. Aarhus Universitet  2. University of Strasbourg 149.00 NONCANONICAL CELL DEATH INDUCTION BY POLY(I:C) INDEPENDENT OF RLR Daniel Boehmer1, Simone Formisano1, Peter Duewell1, Simon Rothenfusser1, Max Schnurr1, Lars M. Koenig1 1. University Hospitals, Ludwig-Maximilians-Universität München, Munich, Germany  150.00 DDX3 AS A MULTI-FUNCTIONAL ADAPTOR MOLECULE IN INNATE IMMUNE SIGNALLING PATHWAYS Martina Schroeder1, Anthony Fullam1, Lili Gu1, Yvette Hoehn1, Niamh McCormack1 1. Maynooth University  151.00 IDENTIFICATION OF NEW MAVS INTERACTION PARTNERS BY ASCORBATE PEROXIDASE (APEX)-MEDIATED IN VIVO PROXIMITY LABELING Viktoria Bothe1, Clarissa Zappe1, Corinna Meyer-Gehlen1, Natalia Kochanova2, Axel Imhof2, Stefan Endres1, Simon Rothenfußer1 1. University Hospital, Ludwig Maximilians University Munich, Germany  2. Munich Center of Integrated Protein Science and Adolf-Butenandt-Institute, Ludwig Maximilians University Munich, Germany 152.00 LENTIVIRAL ACCESSORY PROTEIN VPX IS A DNA SENSING ANTAGONIST THAT SELECTIVELY INHIBITS ACTIVATION OF NFKB SIGNALLING DOWNSTREAM OF CGAS/STING Douglas Fink1, Rebecca Sumner1, Choon Tan1, Greg Towers1 1. University College London  153.00 THE PEROXISOMAL LOCALIZATION OF THE HUMAN CYTOMEGALOVIRUS VMIA IS NOT ESSENTIAL FOR ITS ROLE ON THE INHIBITION OF THE PEROXISOME-DEPENDENT ANTIVIRAL RESPONSE Mariana Marques1, Ana Rita Ferreira1, Isabel Valença1, Daniela Ribeiro1 1. Institute of Biomedicine, University of Aveiro, Portugal  55

Posters

147.00 YELLOW FEVER VACCINE STRAIN 17D TRIGGERS RIG-I-LIKE HELICASES AND INDUCES HIGHLY VARIABLE IMMUNE RESPONSES IN VACCINEES Julia Ahlfeld1, 5, Paul Schwarzlmüller1, Magdalena Scheck1, Giulia Spielmann1, Michael Pritsch2, Giovanna Barba-Spaeth3, Johanna Huber4, Katharina Eisenächer4 Anne Krug4 Simon Rothenfußer1, 5 1. University Hospital of The Ludwig-Maximilians-University, 80337 Munich, Germany  2. Medical Center of the University of Munich (LMU), 80802 Munich, Germany 3. Institut Pasteur, 75015 Paris, France 4. Ludwig-Maximilians-University, 82152 Martinsried, Germany 5. Helmholtz Zentrum München, 85764 Neuherberg, Germany

Posters

154.00 INDUCTION AND INTERFERENCE OF TOLL-LIKE-RECEPTOR 3 SIGNALING BY HEPATITIS A AND HEPATITIS C VIRUS Ombretta Colasanti1, Katharina Esser-Nobis2, Jannik Traut1, Oliver Gruenvogel1 1. University of Heidelberg  2. University of Washington Seattle 155.00 A SINGLE INJECTION DRUG DELIVERY PLATFORM WITH PULSATILE RELEASE KINETICS TO ELICIT ANTIVIRAL IMMUNITY Padmini Pillai1, Jamie Webster1, Kevin McHugh1, Matthew Taylor1, Sviatlana Rose1, Robert Langer1, Ana Jaklenec1 1. Massachusetts Institute of Technology (MIT)  156.00 HUMAN CYTOMEGALOVIRUS’ VMIA DAMPENS ANTIVIRAL SIGNALLING AND CONTROLS PEROXISOME MORPHOLOGY VIA MAVS AND MFF Ana Rita Ferreira1, Ana Gouveia1, Ana Cristina Magalhães1, Jonathan C. Kagan2, Michael Schrader3, Daniela Ribeiro1 1. Institute of Biomedicine, University of Aveiro  2. Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA 3. College of Life and Environmental Sciences, University of Exeter, UK 158.00 A DIVISION OF LABOUR FOR THE TYPE I INTERFERON AND APOPTOSIS INDUCTION AFTER VIRAL INFECTION Tomohiko Okazaki1, Moe Inoue1, Yukiko Gotoh1 4. Graduate School of Pharmaceutical Sciences, The University Of Tokyo  159.00 H5N1 INFLUENZA A VIRUS PB1-F2 CONTROLS PYROPTOTIC CELL DEATH IN INFECTED HUMAN MACROPHAGES Inês Boal-Carvalho1, Béryl Mazel-Sanchez1, Mirco Schmolke1 1. University Of Geneva, Geneva, Switzerland  160.00 NETWORK ANALYSIS OF HOST-VIRUS INTERACTION LANDSCAPE Korbinian Bösl1, Jacques Colinge2,3, Giulio Superti-Furga3,4, Berend Snijder5, Richard K Kandasamy1,6 1. Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway.  2. University of Montpellier, Institut de Recherche en Cancérologie de Montpellier Inserm U1194, Institut régional du Cancer Montpellier, 34000 Montpellier, France. 3. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, 7 Austria. 4. Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. 5. Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, 8093 Zürich, Switzerland. 6. Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, 0349 Oslo, Norway. 56

162.00 INVESTIGATING THE KEY PLAYERS OF NECROPTOSIS UPON VIRAL INFECTION Gaia Trincucci1, Kate Fitzgerald 1 1. UMass Medical School  164.00 DYSREGULATION OF THE INNATE RESPONSE IN HIGH-RISK HUMAN PAPILLOMAVIRUS PERSISTENT INFECTION THROUGH EPIGENETIC MECHANISMS. Marisa Gariglio1, Irene Lo Cigno1, Federica Calati1, Silvia Albertini1, Cinzia Borgogna1, Marco De Andrea2, Santo Landolfo2 1. University of Piemonte Orientale, Medical School  2. University of Turin. Medical School 165.00 Z-FORM NUCLEIC ACID SENSING BY ZBP1/DAI IS REQUIRED TO INDUCE ANTIVIRAL CELL DEATH Jonathan Maelfait1, Layal Liverpool2, Jan Spitaels1, Anne Bridgeman2, Peter Vandenabeele1, Sophie Janssens1, Xavier Saelens1, Wim Declercq1, Jan Rehwinkel2 1. VIB-Ugent Center for Inflammation Research, University of Ghent, Belgium  2. Weatherall Institute of Molecular Medicine, University of Oxford, UK. 166.00 INFECTION WITH A BRAZILIAN ISOLATE OF ZIKA VIRUS GENERATES RIG-I STIMULATORY RNA AND THE VIRAL NS5 PROTEIN BLOCKS TYPE I INTERFERON INDUCTION AND SIGNALLING Jonny Hertzog1, Antonio Gregorio Dias Junior1, Rachel E Rigby1, Claire L Donald2, Alice Mayer1, Chaojun Song3, Boquan Jin3, Philip Hublitz1 Alain Kohl2 Jan Rehwinkel1 1. MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK  2. MRC University of Glasgow Centre for Virus Research, Glasgow, UK 3. The Fourth Military Medical University, Xi’an, PR China

57

Posters

161.00 CELL FATE DECISIONS IN RESPONSE TO VIRAL RNA ARE COORDINATED BY IFNβ Zbigniew Korwek1, Maciej Czerkies1, Wiktor Prus1, Marek Kochańczyk1, Joanna JaruszewiczBłońska1, Karolina Tudelska1, Sławomir Błoński1, Marek Kimmel2,3 Allan, R. Brasier4 Tomasz Lipniacki1 1. Institute of Fundamental Technological Research of the Polish Academy of Sciences, Warsaw, Poland  2. Rice University, Houston, USA 3. Silesian University of Technology, Gliwice, Poland 4. University of Texas Medical Branch, Galveston, USA

Posters

MYELOID DEVELOPMENT 167.00 A FUNCTIONAL HIGH-CONTENT SCREEN IN THP-1 MACROPHAGES IDENTIFIES MICRORNAS INVOLVED IN REGULATION OF PHAGOCYTOSIS Estefania Herdoiza Padilla1, Nicole Wiederspohn1, Sabrina Förster1, Max Senft1, Peter Crauwels1, Tim Bergner1, Paul Walther1, Christian U. Riedel1 1. University Of Ulm  168.00 IL-10 CAUSES EMERGENCY MYELOPOIESIS Ana Cardoso1,2,3,4,5, A. Gil Castro4,5, Isabel Castro4,5, Ana Cumano3, Paulo Vieira3, Margarida Saraiva1,2 1. I3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal  2. IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal 3. Institut Pasteur, 75015 Paris, France 4. ICVS, University of Minho, Braga, Portugal 5. ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal 169.00 HETEROGENEITY OF PLASMACYTOID DENDRITIC CELLS (PDCS) IS REVEALED BY A DISTINCT LINEAGE OF ORIGIN Patrick Rodrigues Fernandes1, Robert Ivanek1,2, Roxane Tussiwand1 1. University of Basel  2. Swiss Institute of Bioinformatics 170.00 IMPAIRED LYSOSOMAL ACIDIFCATION IN A TLR9-DEFICIENT MYELOID POPULATION Kerstin Nündel1, Anette Christ2, Eicke Latz2, Ann Marshak-Rothstein1, S. Schmidt2, S. Sharma3 1. UMass Medical School  2. Universitätsklinikum Bonn 3. Tufts University, Boston, MA, USA 171.00 RESIDENT MACROPHAGES IN THE SKIN INTERCONNECT IMMUNE AND NERVOUS SYSTEM Julia Kolter1,2, Reinhild Feuerstein1, Mirjam Freudenhammer1,5, Nora Hagemeyer3, Marco Prinz3, Tim Lämmermann4, Philipp Henneke1,5 1. Center for Chronic Immunodeficiency, University Medical Center, Freiburg, Germany  2. Faculty of Biology, University of Freiburg, Germany 3. Institute of Neuropathology, University Medical Center, Freiburg, Germany 4. Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany 5. Center for Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany 172.00 TUMOUR-DERIVED MICRORNA-21 REPROGRAMS MACROPHAGE RESPONSES TO LIMIT ANTICANCER IMMUNITY Sarah Case1, Sorcha Poole1, Hannah Prendeville1, Emily Holmes1, Stephanie Elliot1, Emer Hackett1, Cathal Harmon1, Dalal Almuaili1 Cliona O’Farrelly1 Frederick Sheedy1 1. Trinity College Dublin, Ireland. 

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Posters

173.00 EARLY LIFE GUT MICROBIAL CHANGES AFFECT HEMATOPOIESIS IN MICE Eva Fuglsang1, Lukasz Krych1, Mia T. Lundsager1, Dennis S. Nielsen1, Hanne Frøkiær1 1. University of Copenhagen, Frederiksberg C, Denmark  174.00 DISSECTION OF THE MYELOID CELL COMPARTMENT DURING NEUROINFLAMMATION IDENTIFIES NEW DISEASE-MODULATING CELL SUBSETS Marta Jordão1, Stephanie Brendecke2, Roman Sankowski1, Giuseppe Locatelli3, Tai Yi-Heng4, Tuan Tay1, Nora Hagemeyer1, Dominic Gruen5 Martin Kerschensteiner4 Marco Prinz1 1. Institute of Neuropathology, University of Freiburg, Freiburg  2. Oslo University Hospital, Oslo, Norway 3. Theodor Kocher Institute, bern, Switzerland 4. Institut für Klinische Neuroimmunologie, Ludwig-Maximilians Universität München, Munich 5. Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany 175.00 CONSTITUTIVE SIGLEC-1 EXPRESSION BY HUMAN DENDRITIC CELL PRECURSORS ENABLES HIV-1 REPLICATION AND DISSEMINATION TO CD4+ T CELLS Philippe Benaroch1, Nicolas Ruffin1, Ester Gea-Mallorquí1, Mabel Jouve2, Aymeric Silvin1, 3, Peter See3, Charles-Antoine Dutertre3, Florent Ginhoux3 1. Insitut Curie INSERM U932  2. Institut Curie UMR3215 3. Singapore Immunology Network (SIgN), A*STAR 4. Program in Emerging Infectious Disease, Singapore 176.00 CELLULAR AND MOLECULAR INSIGHT INTO THE NATURE, REGULATION AND FUNCTION PROTEASOMES IN MICROGLIA Maja Studencka-Turski1, Frédéric Ebstein1, Heike Junker1, Eileen Schormann1, Elke Krüger1 1. Universitätsmedizin Greifswald  177.00 GENOMIC DISSECTION OF THE TUMOR IMMUNE MICROENVIRONMENT DURING BREAST CANCER PROGRESSION Magdalena Matusiak1, Aaron Newman1, Chloe Steen1, Joseph Foley1, ChunFang Zhu1, Sujay Vennam1, Peipei Lu1, Ash Alizadeh1 Matt van de RIjn1 Rob West1 1. Stanford University, Stanford, CA, USA 

IMMUNITY TO PARASITES 178.00 DECIPHERING THE ROLE OF EOSINOPHILS IN A MOUSE MODEL OF ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS (ABPA) Axel Dietschmann1, Ralf Willebrand1,2, Sebastian Schruefer3, Sven Krappmann3, David Voehringer1 1. Department of Infection Biology, University Hospital Erlangen  2. VIB Laboratory of Translational Immunomodulation Center for Inflammation Research, Hasselt University 3. Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Erlangen   59

Posters

179.00 CYCLIC GMP-AMP SYNTHASE CGAS IS THE CYTOSOLIC SENSOR OF PLASMODIUM FALCIPARUM GENOMIC DNA AND ACTIVATES TYPE I INTERFERONS IN MALARIA Carolina Gallego-Marin1, Jacob E. Schrum1, Warrison A. Andrade1, Scott A. Shaffer1, Lina F. Giraldo2, Alvaro M. Lasso2, Evelyn A. Kurt-Jones1, Kate A. Fitzgerald1 Douglas T. Golenbock1 1. UMass Medical School  2. Centro Internacional de Entrenamiento e Investigaciones Medicas 180.00 SENSING OF TRYPANOSOMA CRUZI BY TLR8 Noria Segueni1, Natalia. A. Juiz2, Silvia A. Longhi2, Alejandro Schijman2, Carine Truyens1 1. Université Libre De Bruxelles, Brussels, Belgium  2. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Buenos Aires, Argentina 181.00 IMMUNOSUPPRESSIVE FUNCTIONS OF HELMINTHS ON INFLAMMATORY RESPONSES IN VITRO AND IN VIVO Amin Zakeri1, Peter Nejsum1, Martin Jakobsen2 1. Aarhus Universityhospital  2. Aarhus University 182.00 PREGNANCY DOWN-REGULATES MHCII EXPRESSION BY MACROPHAGES DURING TOXOPLASMA GONDII INFECTION Margarida Borges1, Carina Brito1, Maria Miguel Castro1, Tânia Magalhães2, Craig Roberts3, Natércia Teixeira1 1. UCIBIO/REQUIMTE, Faculty of Pharmacy University of Porto, Porto, Portugal  2. Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal. 3. Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK 183.00 IMMUNE MODULATORY EFFECTS ON INNATE IMMUNE RESPONSES BY ADULT BODY FLUID FROM PARASITIC HELMINTH, ASCARIS SUUM. Sidsel Dahl Andersen1, Christian Krapp1, Martin Roelsgaard Jakobsen1, Peter Nejsum1 1. Aarhus University, Aarhus, Denmark  184.00 RECOGNITION OF TLR2 AND TLR4 N-GLYCANS BY THE TOXOPLASMA GONDII LECTINS TGMIC1 AND TGMIC4 TRIGGERS HOST CELLS ACTIVATION Flávia Costa Mendonça-Natividade1, Aline Sardinha-Silva 1, Rafael Ricci-Azevedo 1, Carla Duque Lopes 1, Camila Figueiredo Pinzan 1, Igor Correia Almeida 2, Nicholas J. Gay 3, Maria Cristina RoqueBarreira 1 1. University of Sao Paulo  2. University of Texas 3. University of Cambridge

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186.00 INNATE SENSING OF PROTOZOAN PARASITES Felix Yarovinsky, Alexandra Safronova, Daniel Beiting, Alessandra Araujo 1. University of Rochester Medical Center  187.00 γδT CELLS EFFICIENTLY KILL INTRACELLULAR PLASMODIUM FALCIPARUM IN A GRANZYMEDEPENDENT MECHANISM DURING THE MALARIA BLOOD STAGE Maria Andrea Hernandez Castaneda1, Katharina Happ1, Filippo Cattalani1, Alexandra Walliman1, Marianne Blanchard1, Isabelle Fellay1, Luis Filgueira1, Pierre-Yves Mantel1 Michael Walch1 1. Department of Medicine, University of Fribourg, Switzerland  188.00 HYPOXIA-INDUCIBLE FACTOR-1 ALPHA DEFICIENCY RESULTS IN DYSREGULATED LIPID METABOLISM ASSOCIATED WITH INCREASED SUSCEPTIBILITY TO LEISHMANIA DONOVANI INFECTION Inês Mesquita1,2, Carolina Ferreira1,2, Diana Moreira1,2, George Kluck1,2,3, Ana Barbosa1,2, Egídio Torrado1,2, Ricardo Dinis4,5, António Gil Castro1,2 Jérôme Estaquier7,8 Ricardo Silvestre1,2 1. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal 2. ICVS/3B’s–PT Government Associate Laboratory, Braga/Guimarães, Portugal 3. Medical Biochemistry Institute, Federal University of Rio de Janeiro, Brasil 4. Faculty of Medicine, University of Porto, Porto, Portugal 5. IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, University Institute of Health Sciences (IUCS), CESPU, CRL, Gandra, Portugal 6. Faculty of Pharmacy, University of Porto, Porto, Portugal 7. CNRS FR 3636, Université Paris Descartes, 75006 Paris, France 8. Centre de Recherche du CHU de Québec, Université Laval, Québec G1V 4G2, Canada 189.00 MODULATION OF THE HOST LIPID ENVIRONMENT CAN DICTATE THE SUCCESS OF LEISHMANIA INFECTION Diana Moreira1,2,6,7, Inês Mesquita6,7, Jérôme Estaquier3,4, Anabela Silva1,2,5, Ricardo Silvestre6,7 1. IBMC - Instituto de Biologia Molecular e Celular, Portugal  2. I3S - Instituto de Investigação e Inovação em Saúde, Portugal 3. CNRS FRE 3636, Université Paris Descartes, Paris, France 4. Université Laval, Centre de Recherche du CHU, Québec, Canada 5. Faculdade de Farmácia, UPorto, Portugal, 6. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal 7. ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal

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Posters

185.00 THE DSRNA VIRUS FROM LEISHMANIA GUYANENSIS WORSENS INFECTION BY LIMITING NLRP3 INFLAMMASOME ACTIVATION THROUGH A TLR3-TRIF-IFN-β-AUTOPHAGY PATHWAY Renan Villanova Homem de Carvalho1, Djalma de Souza Lima-Júnior1, Marcus Vinícius Gomes da Silva1, Ângela Kaysel Cruz1, Eurico de Arruda Neto1, Dario Simões Zamboni1 1. Ribeirão Preto Medical School, University of São Paulo 

Posters

190.00 TLR3-TRIF SIGNALING PATHWAY MODULATES THE IMMUNE RESPONSE AGAINST NEOSPORA CANINUM INFECTION Vanessa Dos Santos Miranda1, Flávia Batista Ferreira França, Caroline Martins Mota, Vanessa Resende, Mylla Spirandelli da Costa, Patrício da Silva Cardoso Barros, Fernanda Maria Santiago, José Roberto Mineo Tiago Wilson Patriarca Mineo 1. Universidade Federal De Uberlândia  191.00 THE PLASMODIUM FALCIPARUM SPECIFIC NUCLEOSIDE 5’-METHYLTHIOINOSINE IS A NEW TLR8 LIGAND Gabriele Köllisch1, Jeanine Klein1, Stefan Baumeister1, Klaus Lingelbach1, Stefan Bauer2 Department of Parasitology, Philipps University Marburg  1. Institute for Immunology, Philipps University Marburg 192.00 INTERACTION OF TLR2 AND TLR4 WITH TGMIC1 ACCOUNTS FOR THE FORMATION OF NEUTROPHIL EXTRACELLULAR TRAPS INDUCED BY TOXOPLASMA GONDII TACHYZOITES. Rafael Ricci-Azevedo1,2, Giulia Ballestero1, Flávia Costa Mendonça-Natividade1, Denis Girard2, Maria Cristina Roque-Barreira1 1. Laboratory of Immunochemistry and Glycobiology, Department of Cell and Molecular Biology, School of Medicine of Ribeirão Preto, University of São Paulo – Brazil.  2. Laboratoire de Recherche en Inflammation et Physiologie des Granulocytes, University of Québec, INRS-Institut Armand-Frappier, Laval, Québec, Canada. 193.00 DAILY PATTERN OF FEEDING AND RHYTHMIC OSCILLATION OF TNFa PRODUCTION REGULATE SYNCHRONY OF PLASMODIUM CHABAUDI STAGES WITH HOST CIRCADIAN CYCLE Isabella Hirako1,2, Patrícia de Assis2, Natália Hojo-Satchiko1, Helder Nakaya3, Douglas Golenbock2, Roney Coimbra1, Ricardo Gazzinelli1,2,4 1. Instituto De Pesquisas René Rachou – Fundação Oswaldo Cruz MinasInstituto de Pesquisas René Rachou – Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil  2. University of Massachusetts Medical School, Worcester, Massachusetts, USA 3. Escola de Ciências Farmacêuticas – Universidade de São Paulo, São Paulo, Brazil 4. Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil   194.00 TRAINED IMMUNITY BY P. FALCIPARUM REQUIRES T CELL HELP TO INDUCE DENDRITIC CELL MATURATION AND MONOCYTE HYPER-RESPONSIVENESS. Juliet Crabtree1, Jacob Schrum1, Katherine Fitzgerald1, Douglas Golenbock1 1. University Of Massachusetts Medical School  195.00 UNDERSTANDING TYPE 2 RESPONSES IN THE MUCOSA-ASSOCIATED ADIPOSE TISSUE Agnieszka Kabat1, Edward Pearce1 1. Max Planck Institute of Immunobiology and Epigenetics 

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197.00 NLRP3 PREVENTS INHIBITION OF AUTOPHAGY-INDUCED BY TRYPANOSOMA CRUZI IN MACROPHAGES. Kely Catarine Matteucci1, Priscila Andrade2, Soraya Smaili2, Ricardo Weinlich3, Gustavo Pereira2, Karina Bortoluci2 1. University of São Paulo (USP)  2. University Federal of São Paulo (UNIFESP) 3. Israelita Albert Einstein Hospital

NLR/ INFLAMMASOME 198.00 A DIGITAL SIGNALING CIRCUIT DRIVES THE ASSEMBLY OF THE AIM2-ASC INFLAMMASOME Jungsan Sohn1, Mariusz Matyszewski1, Seamus Morrone1 1. Johns Hopkins University School of Medicine  199.00 SPECIFIC NOD2-MICROBIOTA INTERACTIONS DRIVE THE DEVELOPMENT OF CROHN’S DISEASE-LIKE COLITIS Roberta Caruso1, Naohiro Inohara1, Eric Martens1, Nobuhiko Kamada1, Gabriel Núñez1 1. University of Michigan Medical School, Ann Arbor, Michigan, USA.  200.00 THE NLRP3 INFLAMMASOME IS IMMUNOCOMPROMISED IN HUMAN SEPSIS DUE TO MITOCHONDRIAL FAILURE IN MONOCYTES Juan J Martínez-García1, Helios Martinez-Banaclocha1, Diego Angosto1, Carlos de Torre-Minguela1, Joaquín Amores-Iniesta1, Fatima Martín-Sánchez1, Alberto Baroja1, Carlos García-Palenciano1 Pablo Pelegrín1 1. Biomedical Research Institute Of Murcia  201.00 AUTOPHAGY IS A CELL AUTONOMOUS EFFECTOR MECHANISM MEDIATED BY NLRP3 TO CONTROL T. CRUZI INFECTION. Kely Matteucci1, Priscila Andrade1, Ricardo Weinlich2, Gustavo Pereira3, Karina Bortoluci1 1. Department of Biological Science And CTC-Mol - Federal University of São Paulo  2. Albert Einstein Hospital 3. Department of Pharmacology - Federal University of São Paulo 63

Posters

196.00 CYTOTOXIC CD8+T CELLS ACTIVATE INFLAMMASOME IN A MECHANISM DEPENDENT ON GRANZYME B AND PERFORIN IN CUTANEOUS LEISHMANIASIS CAUSED BY L.(V.) BRAZILIENSIS Cláudia Brodskyn1,2,4, Tiago Cardoso1,2,3, Daniel Feijó1, Hugo Almeida1, Lucas Carvalho1,2,3, Vaéria Borges1, Edgar Carvalho1,2,3 1. IGM-FIOCRUZ-Bahia  2. Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil 3. Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT (CNPq/MCT), Salvador, BA, Brazil. 4. Instituto Nacional de Ciência e Tecnologia Instituto de Investigação em Imunologia (CNPq/MCT), São Paulo, SP, Brazil

Posters

202.00 EVALUATION OF OXIDATIVE STRESS, CASPASE-1, ASC AND IL-1B LEVELS IN DIFFERENT BIOLOGICAL FLUIDS OF BODYBUILDERS USING PROTEIN SUPPLEMENTS Kübra Aral1, Eynar Berdeli2, Cüneyt Asým Aral1, Afig Berdeli3, Merve Atan4 1. Malatya Oral and Dental Health Hospital, The Turkish Ministry of Health, Malatya, Turkey  2. Faculty of Dentistry, Izmir Katip Çelebi University, Izmir, Turkey 3. Faculty of Medicine, Ege University, Izmir, Turkey
 4. Ege University, Izmir, Turkey 203.00 LIGAND ACTIVATION OF THE NAIP/NLRC4 INFLAMMASOMES Anna Gram1, John Wright1, Clare Bryant1, 2 1. GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom  2. Cambridge University, Cambridge, Cambridgeshire, United Kingdom 204.00 ROLE OF ADAPTER PROTEIN, ASC IN NANOSILICA INDUCED CYTOTOXICITY IN DIFFERENT LUNG CELL POPULATIONS Shalini Singh1, Nidhi Sharma1, Shivanjali Saxena1, Ishan Agarwal1, Radhika Poojari2, Dulal Panda2, Sushmita Jha1 1. IIT Jodhpur  2. IIT Bombay 205.00 HUMAN CASPASE-4, IN COOPERATION WITH GBPS, DETECTS TETRA-ACYLATED LPS AND CYTOSOLIC FRANCISELLA HIGHLIGHTING FUNCTIONAL DIFFERENCES WITH MURINE CASPASE-11. Brice Lagrange1, Sacha Benaoudia1, Pierre Wallet1, Flora Magnotti1, Fanny Michal1, Amandine Martin1, Flaviana Di Lorenzo2, Bénédicte Py1 Antonio Molinaro2 Thomas Henry1 1. Inserm, Lyon, France  2. University of Napoli Federico II, Napoli, Italy 206.00 PLATELETS BOOST INFLAMMASOME-DERIVED IL-1 CYTOKINES BY REGULATING NLRP3 EXPRESSION Verena Rolfes1, Lisa Böttcher1, Salie Maasewerd1, Lucas S. Ribeiro1, Maximilian Rothe1, James Stunden1, Susanne V. Schmidt1, Eicke Latz1,2,3 Bernardo S. Franklin1 1. Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany  2. Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA 3. German Center for Neurodegenerative Diseases, Bonn, Germany 207.00 HYPERURICEMIA DOES NOT INCREASE EXPRESSION OR ACTIVITY OF THE NLRP3 INFLAMMASOME IN MONOCYTES FROM GOUT PATIENTS Ben Alberts1, James Barber1, Pietro Ghezzi1, Kevin Davies1, Lisa Mullen1 1. Brighton And Sussex Medical School, Brighton, United Kingdom 

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209.00 MARK4 REGULATES NLRP3 POSITIONING AND INFLAMMASOME ACTIVATION THROUGH A MICROTUBULE-DEPENDENT MECHANISM Xuan Li1, Sarah Thome1, Xiaodan Ma2, Mamta Amrute-Nayak3, Alison Finigan1, Lauren Kitt1, Leanne Masters1, John James4 Yuguan Shi5 Ziad Mallat1 1. University of Cambridge  2. Shanghai JiaoTong University 3. Hannover Medical School 4. University of Cambridge, MRC-LMB 5. University of Texas Health Science Center at San Antonio 210.00 ALTERED RESPONSE OF NLRP3-/- MICE TO THROMBOTIC STROKE Eloise Lemarchand1, Jack Barrington1, Alistair Chenery1, Graham Coutts1, Christopher Hoyle1, Judith E Allen1, Stuart M Allan1, David Brough1 1. University Of Manchester  211.00 UNRAVELLING THE COOPERATIVITY BETWEEN TLRS AND INFLAMMASOMES Atul Udgata1 1. University of Cambridge    212.00 NLRP11 NEGATIVELY REGULATES NF-kB AND TYPE I INTERFERON RESPONSES Kornelia Ellwanger1, Emily Becker1, Ioannis Kienes1, Anna Sowa1, Yvonne Postma1, Yamel Cardona Gloria 2, Alexander N.R. Weber2, Thomas Kufer1 1. Institute of Nutritional Medicine, University of Hohenheim  2. Interfaculty Institute for Cell Biology, University of Tübingen 213.00 LIPIN-2 REGULATES SATURATED FATTY ACID-INDUCED NLRP3 INFLAMMASOME ACTIVATION Miren Itziar Sanjuán-García1, 2, Jesús Balsinde1, 2, María Ángeles Balboa1,2 1. Institute of Molecular Biology and Genetics (IBGM), Spanish National Research Council (CSIC), University Of Valladolid  2. Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28029 Madrid, Spain

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Posters

208.00 GRAPHENE OXIDE INHIBITS PRODUCTION OF IL-1β Christopher Hoyle1, Eloise Lemarchand1, Sandra Vranic2,3, Maurizio Buggio2,3, Emily Wang1, Stuart Allan1, Kostas Kostarelos2,3, David Brough1 1. Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, U.K.  2. Nanomedicine Laboratory, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, U.K. 3. National Graphene Institute, University of Manchester, Booth Street East, Manchester, M13 9PL, U.K.

Posters

214.00 ACTIVATION OF NLRC4 DAMPENS ANTIGEN-SPECIFIC, CD4+ T CELL MEMORY IMMUNE RESPONSES AGAINST SALMONELLA TYPHIMURIUM IN MICE INDEPENDENTLY OF CASPASE-1 Panagiotis Tourlomousis1, John Wright1, Paola Zaccone1, Pietro Mastroeni1, Katherine Fitzgerald2, Duncan Maskell1, Clare Bryant1 1. University of Cambridge, Cambridge, UK  2. University of Massachusetts, Worcester, USA 215.00 ALTERNATIVE SPLICING: AN ALTERNATIVE LEVEL OF NLRP3 INFLAMMASOME REGULATION Florian Hoss1, Rebecca Brinkschulte1, Gerald Seifert1, Stefan Canzar2, Matthias Geyer1, Hal M Hoffman3, Eicke Latz1,4,5 1. University Hospital, University of Bonn, Germany  2. Ludwig-Maximilians-Universität München, Munich, Germany 3. University of California San Diego, La Jolla, California, USA. 4. University of Massachusetts Medical School, Worcester, USA. 5. German Center for Neurodegenerative Diseases, Bonn, Germany. 216.00 NON-CANONICAL CASPASE-11 PATHWAY ACTIVATES GASDERMIN-D TO INDUCE PYROPTOSIS LEADING TO CONTROL OF BRUCELLA ABORTUS INFECTION IN MICE Sergio Oliveira1, Daiane Cerqueira1, Marco Tulio Gomes1, Alexandre Silva2, Dario Zamboni2, Petr Broz3 1. Universidade Federal De Minas Gerais, Belo Horioznte-MG, Brazil  2. Universidade de São Paulo-Ribeirão Preto, São Paulo, Brazil 3. University of Basel, Basel, Switzerland 217.00 NLRP3 INFLAMMASOME ACTIVATION IS REGULATED VIA TYROSINE PHOSPHORYLATION BY BRUTON’S TYROSINE KINASE (BTK) Zsofia Bittner1, Xiao Liu1, Franziska Herster1, Juliane Walz1,2, Markus Löffler1, Anita Delor3, Bodo Grimbacher3, Alexander N. R. Weber1 1. Department of Immunology Tübingen  2. Medical Hospital II, University Hospital Tübingen 3. Center for Chronic Immunodeficiency, University Medical Center, Freiburg 218.00 IRF2 REGULATES NON-CANONICAL INFLAMMASOME BY CONTROLLING LEVELS OF CASP4 Sacha Benaoudia1, Brice Lagrange1, Thomas Henry1 1. Ciri  219.00 CROSS-SPECIES INVESTIGATION OF THE INFLAMMASOME Zsofia Digby1, Lee J. Hopkins1, Clare E. Bryant1 1. University Of Cambridge  220.00 THE REGULATION OF EICOSANOID PRODUCTION BY NLRP3 Milton César De Almeida Pereira1, Christine Hinz1, Panagiotis Tourlomousis1, Jules Griffin1, Clare Bryant1 1. University of Cambridge    66

Posters

221.00 PATHOGEN SENSING BY THE NLRP1 INFLAMMASOME Patrick Mitchell1, Andrew Sandstrom1, Edward Mu1, Russell Vance1,2, Joseph Chavarría-Smith1 1. University of California, Berkeley, Berkeley, California, USA  2. HHMI, Berkeley, California, USA 222.00 PATHOGEN BLOCKADE OF TAK1 TRIGGERS CASPASE-8 DEPENDENT CLEAVAGE OF GASDERMIN D AND CELL DEATH Pontus Orning1, 2, Dan Weng1, 4, Kristian Starheim1, 2, Dmitry Ratner1, Zachary Best1, Nobuhiko Kayagaki3, Kate Fitzgerald1, Egil Lien1, 2 1. UMass Medical School, Worcester, MA, USA  2. CEMIR, NTNU, Trondheim, Norway 3. Genentech, San Francisco, CA, USA 4. Nanjing University of Science and Technology, Nanjing, China 223.00 PSEUDOMONAS TRIGGERS DIFFERENTIAL NAIP5-NLRC4 INFLAMMASOME MEDIATED HOST RESPONSES DEPENDING ON ITS CELLULAR LOCALIZATION Elif Eren1, Julien Buyck2, 3, Pierre-Jean Bordignon1, Andre Colom1, Remi Planes1, Jose Santos2, Dirk Bumann2, Olivier Neyrolles1 Peter Broz2, 4 Etienne Meunier1, 2 1. Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France  2. University of Basel, Biozentrum, Focal Area Infection Biology, Basel, Switzerland 3. UFR Medicine and Pharmacy, INSERM U1070, University of Poitiers, France 4. Department of Biochemistry, University of Lausanne, Epalinges, Switzerland 224.00 ROLE OF PHOSPHOLIPASE C IN INFLAMMASOME ACTIVATION Tomasz Prochnicki1, Matthew S. Mangan1, 2, Dagmar Wachten1, 3, Eicke Latz1, 2, 4, 5 1. Institute Of Innate Immunity, University Of Bonn  2. German Center of Neurodegenerative Diseases (DZNE), Bonn, Germany 3. Research Center caesar, Bonn, Germany 4. University of Massachusetts Medical School, Worcester, MA, USA 5. Centre for Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology, Trondheim, Norway 225.00 EFFECT OF MITOTEMPO ON NLRP3 ACTIVATION IS DUE TO A DIRECT INHIBITION OF P2X7 RECEPTOR Carlos De Torre Minguela, Ana Isabel Gómez, Pablo Pelegrín 1. Biomedical Research Institute of Murcia  226.00 MOLECULAR MECHANISM OF NLRP3 INFLAMMASOME ASSEMBLY AND SELF-REGULATION Iva Hafner-Bratkovic1,2, Dusko Lainscek1, Petra Susjan1, Kosta Cerovic1, Lucija Kadunc1, Ana TapiaAbellan3, Diego Angosto-Bazarra3, Pablo Pelegrin3 Roman Jerala1,2 1. National Institute of Chemistry  2. EN-FIST Centre of Excellence 3. Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital “Virgen de la Arrixaca”, Murcia, Spain 67

Posters

227.00 A COMPARISON OF CASPASE 1 AND CASPASE-11 LOCALISATION AND TRAFFICKING IN CANONONICAL AND NON-CANONICAL INFLAMMASOME ASSEMBLY Lee Hopkins1, Alessandro Rizzo, Clare Bryant 1. Department of Veterinary Medicine, University Of Cambridge  228.00 MYD88 INDUCIBLE PATHWAY UNVEILS AN ALTERNATIVE INFLAMMATORY CELL DEATH TRIGGERED BY PSEUDOMONAS AERUGINOSA Rémi Planes1, Elif Eren1, Karin Santoni1, Pierre-Jean Bordignon1, Julien Buyck2, 3, Etienne Meunier1, 2 1. Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France  2. University of Basel, Biozentrum, Focal Area Infection Biology, Basel, Switzerland 3. UFR Medicine and Pharmacy, INSERM U1070, University of Poitiers, France 229.00 CROSS-TALK BETWEEN HUMAN MACROPHAGES AND NK CELLS IN CLEARING BORDETELLA PERTUSSIS: A POSSIBLE ROLE FOR THE NLRP3 INFLAMMASOME Michiel Kroes1, Rob Mariman1, Hendrik-Jan Hamstra1, Jelle de Wit1, Elena Pinelli1 1. National Institute for Public Health and The Environment  230.00 INVESTIGATION OF VIRUS-INDUCED INFLAMMASOMES BY A NOVEL VIRUS-ENCODED FLUORESCENT CASPASE-1 REPORTER Maria Hønholt Christensen1, Yonas Mehari Tesfamariam1, Florian Ingo Schmidt1 1. University Hospital Bonn  231.00 MECHANISM OF CELL DEATH IN CHICKEN MACROPHAGES INFECTED WITH SALMONELLA ENTERICA SEROVAR TYPHIMURIUM John Wright1, Lee Hopkins1, Zsofia Digby1, Panagiotis Tourlomousis1, Arijit Das1, Daniel Wise1, Jim Kaufman1, Clare Bryant 1. University Of Cambridge  232.00 CASPASE-1/IL-18-DEPENDENT IFNγ PROTECTS FROM BURKHOLDERIA INFECTIONS THROUGH INDUCTION OF ROS WHILE CASPASE-11 PROTECTION IS MEDIATED BY PYROPTOSIS OF LUNG EPITHELIAL CELLS Fabio Re1, Jinyong Wang1, Manoranjan Sahoo1, Louis Lantier1, Hector Cordero1, Kelly Deobald1 1. Rosalind Franklin University of Medicine and Science  233.00 STUDYING NLRP3 ACTIVE CONFORMATION BY BIOLUMINESCENT RESONANCE ENERGY TRANSFER Ana Tapia-Abellan1, Diego Angosto1, Iva Hafner-Bratkovič 2, Maria del Carmen Baños-Gregori1, Alberto Baroja-Mazo 1, Pablo Pelegrín1 1. Biomedical Research Institute of Murcia, Murcia, Spain  2. National Institute of Chemistry, Ljubljana, Slovenia

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235.00 LEPTOSPIRA INTERROGANS LIPL21 LIPOPROTEIN BINDING TO PEPTIDOGLYCAN: ESCAPE FROM NOD RECEPTORS SIGNALING AND BACTERIAL CLEARANCE Catherine Werts1, Frédérique Vernel-Pauillac1, Ignacio Santecchia1, Gwenn Ratet1, Allison Williams1, Ivo Boneca1 1. Institut Pasteur  236.00 A NEW HMGB1 HUMAN REPORTER CELL LINE FOR INFLAMMASOME-DERIVED-PYROPTOSIS AND NECROPTOSIS STUDIES. Emmanuel Ravet1, Audrey Reysset1, Rachael Dominguez1, Jean-Paul Reynes1, Eric Perouzel1, Michele Tiraby1 1. Invivogen  237.00 NOD1,2 RECEPTORS COLLABORATE WITH MINCLE RECEPTOR RESULTING IN POTENTIATION OF NF-KB/AP-1 ACTIVITY AND CYTOKINE PRODUCTION AFTER COMBINED STIMULATION IN HUMAN THP-1 CELLS Amir Tukhvatulin1, Alina Dzharullaeva1, Denis Logunov1, Boris Naroditsky1, Alexander Gintsburg1 1. N. F. Gamaleya National Research Center for Epidemiology and Microbiology,  238.00 LIPIN-2 REGULATES INFLAMMASOME ACTIVATION UPON POLY(I:C) STIMULATION IN MACROPHAGES. Nagore De Pablo1, 2, Jesús Balsinde1, 2, María A. Balboa1, 2 1. Instituto De Biología Y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid  2. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) 239.00 CHARCOT-LEYDEN CRYSTALS ACTIVATE THE NLRP3 INFLAMMASOME AND CAUSE IL-1 INFLAMMATION Juan F Rodríguez-Alcázar1, Marco A Ataide2, Gudrun Engels1, Christine Schmitt-Mabmunyo2, Natalio Garbi2, Wolfgang Kastenmüller2, Eicke Latz1,3,4, Bernardo S Franklin1 1. Institute of Innate Immunity - University of Bonn, Bonn, Germany  2. Institute of Experimental Immunology - University of Bonn, Bonn, Germany 3. University of Massachusetts Medical School, Worcester, Massachusetts, USA 4. German Center for Neurodegenerative Diseases, Bonn, Germany.

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234.00 INFLAMMASOMES IN LIVESTOCK: CHARACTERIZATION OF THE NLRP1 INFLAMMASOME RESPONSE TO LETHAL TOXIN IN CATTLE AS A NATURAL HOST SPECIES Catherine Vrentas1, Paola Boggiatto1, Steven Olsen1, Stephen Leppla2, Mahtab Moayeri2 1. U.S. Department of Agriculture  2. National Institutes of Health

Posters

240.00 THE NLRP3 INFLAMMASOME IS DETRIMENTAL IN GASTROINTESTINAL NOROVIRUS INFECTION Andy Wullaert1, Hanne Dubois1, Yvan Saeys1, Liesbet Martens1, Mohamed Lamkanfi1, Frederic Sorgeloos2, Ian Goodfellow2, Soroush Sarvestani3 Jason MacKenzie3 1. Ghent University  2. University of Cambridge 3. University of Melbourne 241.00 CERAMIDE METABOLISM CONTRIBUTES TO ENDOPLASMIC RETICULUM (ER) STRESS INDUCED INFLAMMATION Gang Pei1, Thomas Kufer2, Ivo Boneca3, Anca Dorhoi4, Stefan Kaufmann1 1. Max Planck Institute for Infection Biology, Berlin, Germany  2. Hohenheim University, Stuttgart, Germany 3. Institut Pasteur, Paris, France 4. Friedrich-Loeffler-Institut, Greifswald, Germany 242.00 THE ROLE OF MURINE CASPASE-11 CATALYTIC ACTIVITY AND AUTO-PROCESSING IN GSDMD CLEAVAGE Irma Stowe1, Bettina Lee1, Keith Anderson1, Soren Warming1, Juan Zhang1, Wyne Lee1, Vishva Dixit1, Nobuhiko Kayagaki1 1. Genentech  243.00 INVESTIGATING THE PRODUCTION AND MATURATION OF INTERLEUKIN-18 IN ASTROCYTES IN ALZHEIMER’S DISEASE Stephanie Becker1,2,3, Te-Chen Tzeng1, Tobias Dierkes2,3, Bernardo Franklin2, Eicke Latz1,2,4, Michael Heneka1,3,4, Douglas Golenbock1 1. University of Massachusetts Medical School, Worcester, Massachusetts, United States  2. Institute of Innate Immunity, Bonn, Germany 3. University of Bonn, Bonn, Germany 4. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany 244.00 DISSECTING INFLAMMASOME ACTIVATION WITH ALPACA NANOBODIES Sabine Normann1, Alvin Lu2, Maria H. Christensen1, Karl-Elmar Lange1, Hao Wu2, Hidde L. Ploegh3, Florian Schmidt1 1. University of Bonn, Bonn, NRW, Germany  2. Harvard Medical School, Boston, MA, USA 3. Boston Children’s Hospital, Boston, MA, USA 245.00 CELL FATE AFTER INFLAMMASOME ACTIVATION IS REGULATED BY SARM Michael Carty1, Jay Kearney1, Ryan Thwaites2, Dympna Connolly1, Emily Hams1, Natalia MuñozWolf 1, Giselle Chamberlain2, Claudia Gürtler 1 Katherine Fitzgerald3 Edward Lavelle1 1. Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.  2. Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9RY, UK. 3. University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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247.00 CATALYTIC INACTIVE CASPASE 8 PROMOTES INFLAMMATION AND PYROPTOSIS DURING DEVELOPMENT Katherine Wickliffe, Allie Maltzman, Debra Dugger, Joshua Webster, Merone Roose-Girma, Soren Warming, Vishva Dixit, Kim Newton 1. Genentech  248.00 AZAPEPTIDE MPE001, A CD36 LIGAND PROTECTS AGAINST PHOTORECEPTORS DEGENERATION IN TLR2-MEDIATED RETINAL INFLAMMATION Huy Ong1, Katia Mellal1, Samy Omri1,2, Houda Tahiri1,2, Marie-France Dorion1, Jinqiang Zhang1, Sylvie Marleau1, William Lubell1 Sylvain Chemtob1,2,3 1. Université De Montreal,Montreal , Quebec, Canada  2. Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada 3. Sainte Justine Hospital, Montreal, Quebec, Canada 249.00 LIPIN-2 CONTROLS P2X7 RECEPTOR ACTIVITY AND IL-1BETA PRODUCTION IN MACROPHAGES María Balboa1,2, Gema Lordén1,2 IBGM (CSIC-UVA)  1. CIBERDEM 250.00 FAMILIAL MEDITERRANEAN FEVER MUTATIONS LIFT THE OBLIGATORY REQUIREMENT FOR MICROTUBULES IN PYRIN INFLAMMASOME ACTIVATION Pedro Saavedra1, Hanne Van Gorp1, Nathalia M. de Vasconcelos1, Nina Van Opdenbosch1, Lieselotte Vande Walle1, Magdalena Matusiak1, Filip Van Hauwermeiren1, Dieter Demon1 Fabrizio De Benedetti2 Mohamed Lamkanfi1 1. VIB-UGent Center for Inflammation Research  2. Bambino Gesù Children’s Hospital 251.00 NOVEL NLRP6 MUTATION IDENTIFIED IN A PATIENT WITH AN UNEXPLAINED AUTOINFLAMMATORY DISORDER Sinead Kenealy1, Dina Danso-Abeam 2, Gareth Brady1, Elizabeth J. Ryan2, Ronan T. Leahy3, Emma Creagh1 1. Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland  2. Education and Research Centre, St. Vincent’s University Hospital, Dublin 4, Ireland 3. Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland  

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246.00 A COMMON MECHANISM OF NLRP1B INFLAMMASOME ACTIVATION BY TWO DISTINCT BACTERIAL EFFECTORS Andrew Sandstrom1, Patrick Mitchell1, Edward Mu1, Joseph Chavarria-Smith1, Russell Vance1 1. University of California Berkeley and Howard Hughes Medical Institute 

Posters

252.00 GAIN-OF-FUNCTION VARIANTS IN INFLAMMASOME COMPONENTS CONTRIBUTE TO MULTIPLE SCLEROSIS DEVELOPMENT AND SEVERITY. Jaíne Soares, Dhêmerson Lima, Edione Reis, Fernanda Fernandes, Vinícius Leal, Enedina Oliveira, Alessandra Pontillo 1. University of São Paulo - USP, São Paulo/São Paulo and Brazil  253.00 CHITOSAN WITH LOWER DEGREE OF ACETYLATION DECREASE NLRP3 INFLAMMASOME RESPONSE Daniela Vasconcelos1,2, Carlos Torre-Minguela3, Ana Gomez3, Artur Águas 2, Mário Barbosa1,2, Pablo Pelegrín3, Judite Barbosa1,2 1. i3S/INEB - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal  2. ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal 3. Biomedical Research Institute of Murcia, Murcia, Spain 254.00 NLRP6 AS REGULATOR OF MICROBIOTA AND ATHEROSCLEROSIS Peter Duewell1, Anette Christ2,4,5, Christoph Thaiss3, Max Schnurr1, Eran Elinav3, Eicke Latz2,4,5 1. Klinikum der Universität München, Munich, Germany  2. University of Massachusetts Medical School, Worcester, MA, USA 3. Weizmann Institute of Science, Rehovot, Israel 4. University Bonn, Bonn, Germany 5. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany 255.00 BACTERIAL FLAGELLIN INDUCES A BETTER ACTIVATION OF DENDRITIC CELLS THAN LPS IN HIV+ INDIVIDUALS: PERSPECTIVE FOR NOVEL ADJUVANT IN IMMUNOCOMPROMISED INDIVIDUALS Edione Reis1, Vinícius Leal1, Fernanda Fernandes1, Jaíne Soares1, Dhêmerson Lima1, Alessandra Pontillo1 1. University of Sao Paulo/USP, São Paulo/ São Paulo and Brazil.  256.00 STAT1-MEDIATED TUMOUR SUPPRESSION IS REGULATED BY CASPASE-11 IN A MURINE MODEL OF COLITIS-ASSOCIATED CARCINOGENESIS. Brian Flood1, Joan Manils1, Ewelina Flis1, Elaine W. Kay2, Emma M. Creagh1 1. Trinity Biomedical Sciences Institute, School of Biochemistry & Immunology, Trinity College Dublin, Dublin 2, Ireland  2. Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin 9, Ireland. 257.00 THE CELL TYPE-DEPENDENT EFFECT OF CAFFEINE ON NLRP3 INFLAMMASOME ACTIVATION IN HUMAN MYELOID CELLS Marietta Margit Budai1, Elek Gergõ Kovács1, Zsuzsanna Csáki1, Elek Kocsis1, József Tõzsér1, Szilvia Benkõ1 1. University of Debrecen 

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259.00 ENZYMATICALLY INACTIVE CASPASE-1 INITIATES TUMOR NECROSIS FACTOR MEDIATED INFLAMMATION IN VIVO Stefan Winkler1, Sören Reinke1, Mary Linge1, Hella Luksch1, Angela Rösen-Wolff1 1. Department of Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany  260.00 ROLE OF NLRP3 INFLAMMASOME IN PERIPHERAL BLOOD LEUKOCYTES DURING CHRONIC HIV-1 INFECTION Vinícius Nunes Cordeiro Leal1, Edione Cristina dos Reis1, Jaíne Soares Lima da Silva1, Fernanda Pereira Fernandes1, Dhêmerson Souza de Lima1, Alessandra Pontilllo1 1. Institute of Biomedical Science/University of São Paulo/São Paulo/São Paulo/Brazil  261.00 CASPASE 1 ACTIVITY IMPAIRS CD8+ T CELLS RESPONSES IN CORONAVIRUS INDUCED HEPATITIS Maite Duhalde1, Mathias Jeldres1, Marcelo Hill1,2 1. Laboratory of Immunoregulation and Inflammation. Institut Pasteur de Montevideo. Montevideo, Uruguay  2. Immunobiology Department. Faculty of Medicine. University of the Republic. Montevideo, Uruguay. 262.00 INFLAMMATION BY DANGER RESPONSE IN VISCERAL AND SUBCUTANEOUS ADIPOSE TISSUE FROM OBESE AND LEAN INDIVIDUALS Ivar Myklebust1, Lobke Gierman, Gabriela Silva, Hege Bjøru, Ivan Pavlovic, Anne Mari Rokstad, Bård Kulseng, Ann-Charlotte Iversen 1. NTNU 263.00 MODULATION OF INFLAMMASOME ACTIVATION IN MACROPHAGES BY LEISHMANIA MEXICANA PROTEIN SECRETION Stefania Medellín-Lacedelli1, Alma Reyna Escalona-Montaño1, Araceli Rojas-Bernabé1, Adriana Ruiz-Remigio1, Laila Gutiérrez-Kobeh 1, Arturo Alfredo Wilkins-Rodríguez1, María Magdalena Aguirre-García1 1. UNAM  264.00 A GENOME WIDE CRISPR-SCREEN FOR NLRP3 ACTIVATION IN MURINE BONE MARROW DERIVED MACROPHAGES Niklas Schmacke1, Björn Hiller1, Veit Hornung1 1. Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München 

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Posters

258.00 INFLAMMASOME GENETICS IN INFECTIOUS AND STERILE DISEASES: SHARED MECHANISMS AND NEW CONCEPTS Edione Reis1, Jaine Soares1, Fernanda Fernandes1, Vinicius Leal1, Dhemerson Souza de Lima1, Alessandra Pontillo1 1. University Of Sao Paulo 

Posters

265.00 EVALUATION OF THE CONTRIBUTION OF INFLAMMASSOMA IN THE IMMUNE RESPONSE TO CERVICAL CARCINOMA Fernanda Pereira Fernandes1, Edione Reis1, Dhêmerson Lima de Souza11, Jaíne Soares1, Vinícius Nunes1, Alessandra Pontillo1, Ana Paula Lepique1 1. University of São Paulo, São Paulo, São Paulo/SP Brazil  266.00 THE ROLE OF P110δ PI3K SIGNALING IN NOD2-MEDIATED GASTROINTESTINAL IMMUNITY AND INFLAMMATION Maria González-Núñez 1, Klartje Kok1, Oliver Haworth1, Laura Medrano-Gonzalez1, Klaus Okkenhaug2, Bart Vanhaesebroeck3, Bénédicte Manoury4, Ezra Aksoy1 1. Queen Mary University of London, London, United Kingdom  2. Brabaham Institute, Cambridge, United Kingdom 3. University College London, London, United Kingdom 4. French National Centre for Scientific Research, Paris, France 267.00 CHARACTERISATION OF THE VESICULAR SECRETOME UPON NLRP3 ACTIVATION Christina Franziska Budden1, 2, Linden James Gearing3, Paul Hertzog2, 3, Eicke Latz1, 4, 5 1. Institute of Innate Immunity, University Hospital, University of Bonn, Germany  2. Peter Doherty Institute, University of Melbourne, Australia 3. Hudson Institute of Medical Research, Monash University, Melbourne, Australia 4. Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, USA 5. German Center for Neurodegenerative Diseases, Bonn, Germany   269.00 PYRIN DEPHOSPHORYLATION IS SUFFICIENT TO TRIGGER PYRIN INFLAMMASOME ACTIVATION IN FAMILIAL MEDITERRANEAN FEVER PATIENTS Flora Magnotti1, Lucie Lefeuvre1,2, Sarah Benezech1,2, Louis Waeckel1,2, Amandine Martin1, Mathieu Gerfaud-Valentin2, Thierry Walzer1, Alexandre Belot1,2 Yvan Jamilloux1,2 Thomas Henry1 1. Inserm/CIRI  2. Lyon Hospital 270.00 INFLAMMASOME ASSEMBLY DYNAMICS AND DOWNSTREAM EFFECTORS IN FISH Eva Hasel1, Paola Kuri2, Maria Leptin1, 3, 4 1. Directors’ Research Unit, European Molecular Biology Laboratory, Heidelberg, Germany  2. Perelman School of Medicine, University of Pennsylvania 3. Institute of Genetics, University of Cologne, Cologne, Germany 4. European Molecular Biology Organization, Heidelberg, Germany 271.00 THE ROLE OF NLRP12 IN HEPATOCELLULAR CARCINOMA Hasan Zaki1, SM Nashir Udden1 1. UT Southwestern Medical Center 

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272.00 NKT CELLS HYPERACTIVATE DCS DURING MICROBIAL ENCOUNTER Carlos Donado1,2, Patrick Brennan1,2, Michael Brenner1,2 1. Harvard Medical School, Boston, MA, USA  2. Brigham and Women’s Hospital, MA, USA 273.00 THE DNA INFLAMMASOME IN HUMAN MYELOID CELLS IS INITIATED BY A STING-CELL DEATH PROGRAM UPSTREAM OF NLRP3. Moritz Gaidt1, Thomas Ebert1, Dhruv Chauhan1, Katharina Ramshorn1, Francesca Pinci1, Sarah Zuber1, Fionan O’Duill1, Jonathan Schmid-Burgk1 Florian Hoss2 Raymund Buhmann3 Georg Wittmann3 Eicke Latz Marion Subklewe Veit Hornung 1. Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität Munich, Munich, 81377, Germany  2. Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany 3. Department of Transfusion Medicine, University Hospital Grosshadern, Ludwig-MaximiliansUniversität Munich, Munich, 81377, Germany 4. Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA 5. Laboratory for Translational Cancer Immunology, Gene Center, Ludwig-Maximilians-Universität Munich, Munich, 81377, Germany 6. Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität Munich, Munich, 81377, Germany  274.00 REGULATION OF THE NLRP3 INFLAMMASOME BY A NOVEL MECHANISM. Sambit Nanda1, Philip Cohen1, Thomas William Monteiro-Crozier2, Tony Ly2 1. MRC Protein Phosphorylation and Ubiquitylation Unit  2. The Centre for Gene Regulation and Expression 275.00 OMEGA-3 REVERTS NLRP3-INOS PATHWAY IN THE CONTEXT OF TYPE 1 DIABETES Mariana Davanso1,2,3, Amanda Crisma1, Tarcio Braga1, Maximilian Rothe2, Pia Langhoff2, Mario Lauterbach2, Eicke Latz2, Rui Curi1 1. University São Paulo, São Paulo, São Paulo, Brazil  2. University of Bonn, Bonn, North Rhine-Westphalia, Germany 3. University of Tuiuti of Paraná, Curitiba, Paraná, Brazil 276.00 NAIP IS INVOLVED IN THE INFLAMMASOME SIGNALING DOWNSTREAM TO SOLUBLE URIC ACID ACTIVATION Tarcio Braga1,2,3, David Mendes2, Mariana Davanso2,3, Tiago Souza2, Tomasz Prochnicki3, Mario Lauterbach3, Carlos Menck2, Eicke Latz3 Niels Camara2,4 1. Federal University Of Parana  2. University of Sao Paulo 3. University of Bonn 4. Federal University of Sao Paulo 277.00 REGULATION OF NLRP3 INFLAMMASOME ACTIVATION BY XIAP Yung-Hsuan Wu1, Shu-Ting Mo, Ming-Zong Lai 1. Academia Sinica   

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278.00 ROLE OF NOD1 IN HUMAN TOLEROGENIC DENDRITIC CELLS Theresa Neuper1, Muamera Sarajlic2, Gernot Posselt3, Silja Wessler4, Jutta Horejs-Hoeck5 1. University of Salzburg  279.00 CAGPAI-DEPENDENT INNATE ACTIVATION OF HUMAN MYELOID CELLS BY THE BACTERIAL PATHOGEN HELICOBACTER PYLORI Christine Josenhans1, 2, Saskia Stein2, Eugenia Faber2 1. Ludwig Maximilians University Munich, Max von Pettenkofer Institute, Munich, Germany  2. Hannover Medical School, Institute for Medical Microbiology, Hannover, Germany  280.00 GERM-CELL SPECIFIC NLRP14 IS A NEGATIVE REGULATOR OF CYTOSOLIC NUCLEIC ACID SENSING Sagi Shapira1,2,3, Takayuki Abe1,2,3, Albert Lee1, Ramaswami Sitharam1,2,3, Raul Rabadan1,2 1. Columbia University  2. Dep of Systems Biology 3. dep of Microbiology and Immunology 281.00 REPURPOSING OF CARDIOVASCULAR DRUGS FOR THE TREATMENT OF IL-1 MEDIATED DISEASE Fiachra Humphries1, Paul Moynagh2, Katherine Fitzgerald 1 1. UMASS Medical School  2. Maynooth University 282.00 ENTAMOEBA HISTOLYTICA INDUCED CASPASE-4 ACTIVATION REGULATES IL-1β SECRETION THROUGH CASPASE-1 Kris Chadee4, Jeanie Quach1, France Moreau2, Christina Sandall3 1. University of Calgary  283.00 IONIC CONTROL OF THE NLRP3 INFLAMMASOME BY SALT Shi Yu1, Jack Green2, Catherine Lawrence3, David Brough4 1. University Of Manchester  284.00 A MITOCHONDRIA LOCALIZED MICROPEPTIDE ENCODED FROM AN ANNOTATED LONG NONCODING RNA REGULATES INFLAMMATORY RESPONSE Ankit Bhatta1, Maninjay Atianand2, Daniel Caffrey1, Katherine A Fitzgerald1 1. University of Massachusetts Medical School  2. University of Pittsburgh

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FLY IMMUNITY 286.00 THE KINASE IKKβ REGULATES A STING AND NF-kB-DEPENDENT ANTIVIRAL RESPONSE IN DROSOPHILA Hua Cai1,2, Akira Goto1, Kiyoshi Okado1, Nelson Martins1, Laurent Daeffler1, Jean-Luc Imler1 1. Université De Strasbourg, CNRS, Réponse Immunitaire Et Développement Chez Les Insectes, UPR9022  2. Sino-French Hoffmann Institute, State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China. 287.00 ROLE OF UBIQUITINATION IN THE GENETIC VARIATION OF DROSOPHILA ANTIVIRAL IMMUNITY Rupinder Kaur1, Miguel Landum1, Anastasiya Kryzhanska1, Nelson Martins1,2, Luis Teixeira1 1. Instituto Gulbenkian de Ciência, Oeiras, Portugal  2. Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France 288.00 UNIQUE STRUCTURAL ORGANISATION OF A DUPLICATED TOLL RECEPTOR IN THE MOSQUITO AEDES AEGYPTI Monique Gangloff1, Yoann Sauceereau1 1. University of Cambridge  289.00 STRUCTURAL DIVERGENCE OF THE MOSQUITO TOLL LIGAND SPÄTZLE Yoann Saucereau1, Monique Gangloff 1. University of Cambridge  291.00 IMMUNITY AND MEMORY AGAINST MALARIA: AN ATLAS OF THE MOSQUITO IMMUNE SYSTEM AT SINGLE CELL RESOLUTION Gianmarco Raddi1,2,3, Carolina Barillas-Mury2, Oliver Billker1 1. Wellcome Trust Sanger Institute, University of Cambridge, Cambridge, UK  2. National Institutes of Health, Bethesda, MD, USA 3. University of California Los Angeles, Los Angeles, CA, USA 292.00 THE NF-kB INHIBITOR IMD-0354 AFFECTS IMMUNE GENES EXPRESSION, BACTERIAL MICROBIOTA AND TRYPANOSOMA CRUZI INFECTION IN RHODNIUS PROLIXUS MIDGUT Cecilia Vieira1, Daniele Castro, Peter Waniek, Patrícia Azambuja 1. Instituto Oswaldo Cruz  2. Universidade Federal Fluminense 77

Posters

285.00 NLRP3 ACTIVATION AND LYSOSOMAL CATHEPSINS ARE NON-REDUNDANT PATHWAYS THAT CONTRIBUTES TO NAIP/NLRC4 INFLAMMASOME RESPONSES TO FLAGELLIN. Laura Branco1,2, Silvia Lage1,2,3, Ricardo Weinlich4, Karina Bortoluci1 1. Universidade de São Paulo, São Paulo, Brazil, Brazil  2. Universidade Federal de São Paulo, São Paulo, Brazil 3. National Institutes of Health, Bethesda, United States of America 4. Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil

Posters

INTRACELLULAR PATHOGENS 293.00 WOODCHUCK TOLL-LIKE RECEPTORS 1 TO 10 AND THEIR DIFFERENTIAL EXPRESSION IN DISTINCT IMUNOVIROLOGICAL FORMS OF EXPERIMENTAL HEPATITIS B VIRUS INFECTION Thomas Michalak1, John Bradley Williams1, Alena Huppner1, Patricia Mulrooney-Cousins1 1. Memorial University Of Newfoundland  294.00 THE P38 KINASE SIGNALING PATHWAY IS RESPONSIBLE FOR THE EARLY EXPRESSION OF IL12B AND IL10 IN DENDRITIC CELLS BY FRANCISELLA TULARENSIS INVASION Jiri Stulik1, Ivo Fabrik1, Marek Link1, Ivona Pavkova1, Lenka Plzakova1, Zuzana Krocova1, Daniela Putzova1, Pavel Rehulka1 1. FMHS UO Hradec Kralove Czech Republic  295.00 TRANSMEMBRANE TNF REGULATES THE PRESENCE OF CD3+ TCRab+/TCRab- MYELOID CELLS AFTER BCG INFECTION Adriana Rodriguez-Cruz1, Lucero Ramon-Luing1, Claudia Carranza1, Ricardo Lascurain-Ledesma2, Valerie Quesniaux3, Bernhard Ryffel3, Irene Garcia4, Leslie Chavez-Galan1 1. Instituto Nacional De Enfermedades Respiratorias  2. Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico. 3. UMR7355, University of Orléans, Francia. 4. Faculty of Medicine, University of Geneva, Geneva, Switzerland. 298.00 INTERLEUKIN-10 IS CRITICAL FOR THE PROTECTION OF MICE FROM LETHALITY BY LUNG INFECTION OF ACINETOBACTER BAUMANNII Min-Jung Kang1, Jong-Hwan Park1 1. Chonnam National University  299.00 INNATE IMMUNE RESPONSES VIA MYD88 AND TLR IS ESSENTIAL INVASION-DEPENDENT INNATE IMMUNE STIMULATION OF EPITHELIAL CELLS Kaiyi Zhang1 1. Institute of Medical Microbiology 

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300.00 MYCOBACTERIUM TUBERCULOSIS LIMITS GLYCOLYSIS TO EVADE MACROPHAGE INNATE IMMUNE RESPONSES VIA MODULATION OF MICRORNA-21 Emer Hackett1, Seonadh O’Leary1, Sinead Corr1, Joseph Keane1, Frederick Sheedy 1. Trinity College Dublin  301.00 MITOCHONDRIAL CYCLOPHILIN D AS A NOVEL MEDIATOR OF HOST TOLERANCE TO INFLUENZA A VIRUS INFECTION Jeffrey Downey1, Erwan Pernet1, Maziar Divangahi1 1. McGill University, Montreal, Quebec, Canada 

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303.00 1-PALMITOYL-2-LINOLEOYL-3-ACETYL-RAC-GLYCEROL (PLAG) PREVENTS STREPTOZOTOCININDUCED PANCREATIC β-CELL DYSFUNCTION AND MAINTAINS A NON-DIABETIC CONDITIONS Jimin Kim1,2, Jae Wha Kim1,2, Do Young Lee3, Byoung-Gon Moon3, Ki-Young Sohn3, Sun Young Yoon3 1. Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea  2. University of Science and Technology, Daejeon, Republic of Korea 3. ENZYCHEM Lifesciences, Jecheon, Republic of Korea 304.00 STING AGONISTS ENABLE ANTIVIRAL CROSS-TALK BETWEEN HUMAN CELLS AND CONFER PROTECTION AGAINST GENITAL HERPES IN MICE Alice Knudsen1, Morten Skouboe1, Line Reinert1, Cedric Boularan2, Thierry Lioux2, Eric Perouzel2, Martin Thomsen1, Søren Paludan1 1. Aarhus University, Aarhus, Denmark  2. InvivoGen, Toulouse, France 305.00 1-PALMITOYL-2-LINOLEOYL-3-ACETYL-RAC-GLYCEROL ATTENUATES CONCANAVALIN A-INDUCED HEPATITIS Young-Eun Ko1, Sun Young Yoon2, Do Young Lee2, Byoung-Gon Moon2, Ki-Young Sohn2, Jae Wha Kim1 1. Korea Research Institute of Bioscience and Biotechnology  2. ENZYCHEM Lifesciences   306.00 COMMON MONOCYTE PROGENITORS ARE NOVEL ANTIMYCOBACTERIAL EFFECTOR CELLS Anne Kathrin Lösslein1, Kourosh Gharun1,2, Lisa Scheuermann3, Florens Lohrmann1,4,5, Julia Kolter1,2, Aaron Forde1,2, Anca Dorhoi3, Philipp Henneke1,5 1. Center for Chronic Immunodeficiency (CCI), Medical Center – University of Freiburg, Freiburg, Germany  2. Faculty of Biology, University of Freiburg, Freiburg, Germany 3. Max Planck Institute for Infection Biology, Berlin, Germany 4. Spemann Graduate School for Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany 5. Center for Pediatrics and Adolescent Medicine, Medical Center – University of Freiburg, Freiburg, Germany

79

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302.00 INTESTINAL DYSBIOSIS COMPROMISES ALVEOLAR MACROPHAGE IMMUNITY TO MYCOBACTERIUM TUBERCULOSIS Nargis Khan1, Laura Mendonca1, Achal Dhariwal1, Ghislaine Fontes1, Dick Menzies1, Jianguo Xia1, Maziar Divangahi1, Irah King1 1. McGill University 

Posters

307.00 EDUCATION OF STEM CELLS BY BCG: AN INNOVATIVE APPROACH IN TB VACCINE DEVELOPMENT Eva Kaufmann1,4, Joaquin Sanz2,3, Jonathan L. Dunn1,4, Nargis Khan1,4, Laura E. Mendonca1,4, Irah L. King1,4, Anastasia Nijnik4, Clinton S. Robbins5 Luis B. Barreiro2,3 Maziar Divangahi1,4 1. McGill University Health Centre, Meakins-Christie Laboratories  2. Université de Montréal, Canada 3. CHU Sainte-Justine Research Center, Montreal, QC, Canada 4. McGill University, Montreal, QC, Canada 5. University of Toronto, Toronto, ON, Canada 308.00 AN ANTIMYCOBACTERIAL MECHANISM INDEPENDENT OF IFNγ SIGNALING IN MACROPHAGES Mariana Resende1,2, Marcos S. Cardoso1, Ricardo Fróis-Martins1, Margarida Borges3, Michael B. Jordan4, António Gil Castro2, Rui Appelberg1 1. I3S - Instituto de Investigação e Inovação em Saúde/ IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal  2. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho/ ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal 3. Faculty of Pharmacy, University of Porto, Portugal 4. Cincinnati Children’s Hospital Medical Center/University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA 309.00 DECIPHERING THE MOLECULAR BASES OF MYCOBACTERIA AND LIPOGLYCAN RECOGNITION BY THE C-TYPE LECTIN DECTIN-2 Alexiane Decout1,2,4, Sandro Silva-Gomes 1, Daniel Drocourt 2, Martine Gilleron 1, Jacques Prandi 1, Karen Dobos 3, Michel Rivière 1, Mary Jackson 3 Gérard Tiraby 2 Jérôme Nigou 1 1. Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, 205 route de Narbonne, F-31077 Toulouse, France  2. InvivoGen, Research Department, F-31400 Toulouse, France 3. Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 4. Ecole Polytechnique Fédérale De Lausanne 310.00 VIRAL PROTEASE INHIBITION CAUSES HIV-1 TO ACTIVATE DNA SENSOR CGAS Rebecca Sumner1, Thomas Peacock1, Greg Towers1 1. University College London  311.00 THE COMMON HAQ STING VARIANT IMPAIRS CGAS-DEPENDENT ANTIBACTERIAL RESPONSES AND IS ASSOCIATED WITH SUSCEPTIBILITY TO LEGIONNAIRES’ DISEASE IN HUMANS Juan S. Ruiz-Moreno1, Lutz Hamann1, Javeed A. Shah2, 3, Annelies Verbon4, Frank P. Mockenhaupt1, Monika Puzianowska-Kuznicka5, Ralf R. Schumann1, Lei Jin6 Thomas R. Hawn2 Bastian Opitz1 1. Charité Universitätsmedizin Berlin, Berlin, Germany  2. University of Washington, Seattle, Washington, United states of America 3. VA Puget Sound Health Care System, Seattle, Washington, United states of America 4. Erasmus University Medical Center, Rotterdam, The Netherlands 5. Polish Academy of Sciences, Warsaw, Poland 6. University of Florida, Gainesville, Florida, United States of America

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313.00 ANTI-GM-CSF THERAPY AND TUBERCULOSIS: MECHANISMS OF DISEASE EXACERBATION Lúcia Moreira-Teixeira1, Philippa Stimpson 1, Sabelo Hadebe 1, Evangelos Stavropoulos 1, Probir Chakravarty 1, Eleanor Ross 2, Xuemei Wu 1, Anne O’Garra 1,3 1. The Francis Crick Institute  2. Royal Veterinary College, London, United Kingdom 3. Imperial College London, London, United Kingdom 314.00 LRRK2 REGULATES PHAGOSOME MATURATION AND INFLAMMATORY RESPONSES TO M. TUBERCULOSIS Susanne Herbst1, Angela Rodgers1, Anetta Härtlova2, Matthias Trost2, Maximiliano Gabriel Gutierrez1 1. The Francis Crick Institute, London, UK  2. Newcastle University, Newcastle-upon-Tyne, UK 315.00 EARLY SIGNALING PATHWAYS INDUCED IN MACROPHAGES BY MYCOBACTERIUM TUBERCULOSIS INFECTION Arnaud Machelart1, Christophe Queval1, Samuel Jouny1, Eik Hoffmann1, Nathalie Deboosere1, Isabelle Ricard1, Alexandre Vandeputte1, Ok-Ruyl Song1 Mathias Chamaillard1 Priscille Brodin1 1. University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 – UMR 8204-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France.  316.00 HOST-PATHOGEN INTERACTIONS IN MYCOBACTERIUM TUBERCULOSIS INFECTION OF AIRWAY EPITHELIAL CELLS Stacey-Ann Lee1, Robert Heyderman2, Rachel Lai1, Katalin Wilkinson1, Robert Wilkinson1 1. The Francis Crick Institute, London, UK  2. University College London, London, UK 317.00 USING HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED MACROPHAGES TO STUDY AUTOPHAGY IN MYCOBACTERIUM TUBERCULOSIS INFECTION Elliott Bernard1, Rachel Lai1, Maximiliano Gutierrez1 1. The Francis Crick Institute  318.00 THE IMPACT OF GLYCANS MODULATION DURING MYCOBACTERIUM TUBERCULOSIS INFECTION Kaori Fonseca1, Rita Matos1, Ana Raquel Maceiras1, Leandro Barros1, Joana Gomes1, Pedro Rodrigues1,2, Celso Reis1,2, Ana Magalhães1 Margarida Saraiva1 1. I3S - Instituto De Investigação E Inovação Em Saúde, Porto, Portugal  2. University of Porto, Porto, Portugal 81

Posters

312.00 THE INFLUENCE OF POSTNATAL INFECTIOUS CHALLENGE ON ENTERIC TISSUE MATURATION Stefan Schlößer1, Nastaran Fazel Modares 1, Kaiyi Zhang1, Urska Repnik 2, Aline Dupont 1, Mathias Hornef 1 1. University Hospital RWTH Aachen, Aachen, Germany  2. Section for Physiology and Cell Biology, Oslo University, Oslo, Norway

Posters

319.00 IDENTIFICATION OF TWO NEW POLYPEPTIDES FROM SEGMENT 2 OF IAV THAT MODULATE THE TYPE I INTERFERON RESPONSE Rute Maria Pinto1, Helen Wise1, Liliane Man-Wah Chung1, Marlynne Quigg-Nicol1, Samantha Lycett1, Bernadette Dutia1, Paul Digard 1. The Roslin Institute, The University of Edinburgh  320.00 FUNCTIONAL IMPACT OF DIFFERENTIAL IL-1 SIGNALING IN TUBERCULOSIS Jeremy Sousa1,2, Leandro Barros1,2, Kaori Fonseca1,2, Nuno Osório3,4, Angelica Ramos5, Teresa Carvalho5, António Castro3,4, João Guimarães5,6 Helder Bastos3,4,7 Margarida Saraiva1,2 1. i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal  2. Institute for Molecular and Cell Biology, Univiversity do Porto, Porto, Portugal 3. Life and Health Sciences Research Institute, University of Minho, Braga, Portugal 4. ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal 5. São João Hospital Center & EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal 6. Faculty of Medicine, University of Porto, Porto, Portugal 7. São António Hospital, Porto, Portugal 321.00 HUMAN STING POLYMORPHISMS AFFECT IMMUNE SENSING OF CYCLIC DINUCLEOTIDES AND LISTERIA MONOCYTOGENES Thomas Zillinger1, Eva Bartok1, Hildegard Schilling1, Fabian Ullricht1, Mang Xu1, Gunther Hartmann1, Winfried Barchet1,2 1. University Hospital Bonn, Bonn, Germany  2. German Center for Infection Research (DZIF), Bonn, Germany   322.00 WOLBACHIA GROWTH REGULATION MECHANISMS REVEALED BY FORWARD GENETICS Elves Heleno Duarte1,2, Ana Carvalho1, Luis Teixeira1,3 1. Instituto Gulbenkian de Ciência, Portugal  2. Universidade de Cabo Verde, Cabo Verde 3. Universidade de Lisboa, Portugal 323.00 A NOVEL MODE OF IMMUNE INDUCTION IMPACTS VECTOR COMPETENCE FOR TICKTRANSMITTED PATHOGENS Dana Shaw1,2, Xiaowei Wang2, Adela Oliva Chávez2, Kathryn Reif3,4, Erin McClure2, Massaro Ueti4, Jose de la Fuente5,6, Utpal Pal7 Erol Fikrig8,9 Joao Pedra2 1. Washington State University, Pullman, WA USA  2. University of Maryland, Baltimore, MD USA 3. Kansas State University, Manhattan, KS USA 4. United States Department of Agriculture, Pullman, WA USA 5. IREC, CSIC-UCLM-JCCM, Ciudad Real, Spain 6. Oklahoma State University, Stillwater, OK USA 7. University of Maryland, College Park, MD USA 8. Yale University, New Haven, CT USA 9. Howard Hughes Medical Institute, Chevy Chase, MD USA

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325.00 IMMUNOMETABOLIC HOST RESPONSES OF ITACONATE TO MYCOBACTERIUM TUBERCULOSIS Eik Hoffmann1,2, Arnaud Machelart1,2, Ok-Ryul Song1,2, Samuel Jouny1,2, Nathalie Deboosere1,2, Isabelle Ricard1,2, Priscille Brodin1,2 1. Pasteur Institute Lille, France  2. Center for Infection and Immunity of Lille (CIIL), France 326.00 CAVEOLIN-1 MODULATES MYCOBACTERIA-INDUCED SIGNALING PATHWAYS IN MYEOLID DERIVED SUPPRESSOR CELLS Vini John1, Manfred Lutz1 1. Institute of Virology and Immunobiology  327.00 COMPREHENSIVE PAN-VIRAL INTERACTOME UNCOVERS FUNCTIONAL AND EVOLUTIONARY FEATURES UNDERLYING VIRUS-HUMAN INTERACTIONS Sagi Shapira1,2,3, Gorka Lasso1,2,3, Sandra Mayer1,2,3, Evandro Wilkelmann1,2,3, Tim Chu1,2, Oliver Elliot1,2, Juan Patino-Galindo1,2, Donald Petrey1,2 Raul Rabadan1,2 Barry Honnig1,2,4 1. Columbia University  2. Dep of Systems Biology 3. Dep of Microbiology and Immunology 4. Howard Hughes Medical Institute 328.00 THE ROLE OF INTERFERON-γ IN RESTRICTING MYCOBACTERIUM TUBERCULOSIS INFECTION Marietta Ravesloot-Chavez1, Jonathan Braverman1, Sarah Stanley1 1. University of California Berkeley, Berkeley, California, USA  329.00 DETERMINANTS OF IMMUNOSUPPRESSION BY PHAGOSOME-CONFINED MONOCYTOGENES Alfredo Chavez-Arroyo1, Brittney Nguyen1, Maria Krasilikov1, Daniel Portnoy1 1. University of California Berkeley, Berkeley, California, USA 

LISTERIA

 330.00 INFLAMMATORY SIGNALLING AMPLIFICATION DURING EPITHELIAL INFECTION BY SHIGELLA – NEW INSIGHT ON SENSING OF INVADING BACTERIA Laura Barrio Cano1, Samy Gobaa1, Jost Enninga1 1. Institut Pasteur 

83

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324.00 MODULATION OF LIPID BIOGENESIS AND LIPID ANTIGEN PRESENTATION DURING INFECTION OF LEGIONELLA PNEUMOPHILA Gabriel Araujo1, Dalila Ribeiro1, Dario Zamboni2, Kelly Magalhães1 1. Universidade De Brasilia  2. Universidade de São Paulo

Posters

SUBCELLULAR SIGNALING 331.00 INTERACTION BETWEEN THE ER-STRESS ASSOCIATED MOLECULE IRE1 AND INNATE ACTIVATION IN PDC Carolina Silva1, Rita Faria1, Voahirana Camosseto2, Paulo Antas1, Evelina Gatti1,2, Catarina R. Almeida1,3, Philippe Pierre1,2 1. IBiMED - Institute for Biomedicine  2. CIML - Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, France 3. Department of Medical Sciences, University of Aveiro, Portugal 332.00 IL-1 CYTOKINES IN STREPTOCOCCUS PYOGENES INFECTION: NEW VIEW OF KNOWN PLAYERS Kevin Eislmayr1, Annika Bestehorn1, Pavel Kovarik1 1. University Of Vienna  333.00 IRAP+ ENDOSOMES REGULATE TOLL-LIKE RECEPTOR 9 SIGNALING IN DENDRITIC CELLS Joel Babdor1, Delphyne Descamps2, Luiz Vasconcellos1, Loredana Saveanu3, Bénédicte Manoury1 1. Institut Necker Enfants Malades, INSERM U1151- CNRS UMR 8253  2. VIM, INRA, Université Paris Saclay 3. INSERM, UMR 1149, Centre de Recherche sur l’inflammation   334.00 DISCOVERING NOVEL REGULATORS OF IL-1α PROCESSING Michael Daniels1, Jack Rivers-Auty1, Nadia Luheshi2, David Brough1 1. University of Manchester, Manchester, Greater Manchester, UK  2. MedImmune Ltd, Cambridge, Cambridgeshire, UK 335.00 THE CROSSTALK BETWEEN AUTOPHAGY AND INFLAMMATION IN PLASMACYTOID DENDRITIC CELLS Carolina Silva1, Paulo Antas1, Voahirana Camosseto2, Evelina Gatti1, 2, Philippe Pierre1, 2, Catarina Almeida1 1. Institute of Biomedicine – IBiMED, University of Aveiro  2. CIML - Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, France 336.00 TRANSCRIPTIONAL REGULATION OF CYTOKINE INDUCTION BY MOUSE PYHIN PROTEIN IFI207 Marcin Baran1, Zhaozhao Jiang2, Philipp Hubel3, Jennifer L. Swantek4, Sreya Ghosh2, Anthony J. Slavin4, Andreas Pichlmair3, Katherine Fitzgerald2 Andrew Bowie1 1. Trinity College Dublin, Ireland  2. University of Massachusetts Medical School, Worcester, Massachusetts, USA 3. Max-Planck Institute for Biochemistry, Martinsried, Germany 4. AbbVie Bioresearch Center, Worcester, Massachusetts, USA

84

Posters

337.00 RIPK2 FORMS DISTINCT COMPLEXES UPON BACTERIAL INFECTION Christine Arnold1, Kornelia Ellwanger1, Mariana Mohr1, Herbert Schmidt1, Thomas Kufer1 1. University Of Hohenheim  338.00 DNGR-1 CONTROLS THE EXTENT OF DAMAGE BY DAMPENING NEUTROPHIL RECRUITMENT TO INJURED TISSUES Carlos Del Fresno1, Paula Saz-Leal1, Michel Enamorado1, Stephanie Wculek1, Sarai MartínezCano1, Oliver Schulz2, Eva Cano3, Anna Planas4 Caetano Reis e Sousa5 David Sancho6 1. Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC-ISCIII), Madrid, Spain  2. The Francis Crick Institute, London, UK 3. Instituto de Salud Carlos III, Majadahonda, Madrid, Spain 4. Institut d’Investigacions Biomèdiques de Barcelona (IIBB-CSIC), Barcelona, Spain 5. The Francis Crick Institute, London, UK 6. Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC-ISCIII), Madrid, Spain  339.00 IMPACT OF C-MAF DEFICIENCY ON MURINE INKT CELL-DRIVEN ACUTE EXPERIMENTAL HEPATITIS Shi-Chuen Miaw1, Jhang-Sian Yu1, Michito Hamada2, Keigyou Yoh2, Satoru Takahashi2 1. Graduate Institute of Immunology, National Taiwan University College of Medicine  2. Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba 340.00 NUCLEAR ZBP1/DAI PROMOTES MCMV-INDUCED NECROPTOSIS Katherine Ragan1, Jason Upton1 1. University of Texas, Austin  341.00 THE ROLE OF RECYCLING ENDOSOMES AND SECRETORY VESICLES IN TLR2 SIGNALING Bijaya Sharma1, Urmila Powale1, Morgen Clarke1, Stephen Bunnell1, Linden Hu1, Tanja PetnickiOcwieja1 1. Tufts University  342.00 SCAVENGER RECEPTOR MSR-JNK PATHWAY CONTROL ALTERNATIVELY ACTIVATED MACROPHAGES Anetta Sviotorka Hartlova1, Manman Guo2, Matthias Trost1 1. Newcastle University  2. University of Dundee

PHENOTYPIC

SWITCH

OF

85

Posters

343.00 PEROXIREDOXIN-MEDIATED DISULFIDE BOND FORMATION IS REQUIRED FOR NUCLEOCYTOPLASMIC TRANSLOCATION AND SECRETION OF HMGB1 IN RESPONSE TO INFLAMMATORY STIMULI Jeon-Soo Shin1,2,3,5, Man Sup Kwak1, Hee Sue Kim1,2, Young Hun Kim1,2, Myung Gil Hahn1,2, Jae Min Shin1,2, In Ho Park3, Ji Eun Choi4 Sue Goo Rhee3 1. Department of Microbiology, Yonsei University College of Medicine, Seoul 03722, Korea  2. Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea 3. Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea 4. Seoul National University Boramae Hospital, Seoul National University College of Medicine, Seoul 07061, South Korea 5. Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Korea 344.00 GAIN-OF-FUNCTION MUTATION IN THE KERATINOCYTE SIGNALOSOME PROTEIN CARD14 DRIVES IL-23/IL-17-MEDIATED SKIN INFLAMMATION IN VIVO Mark Mellett1, Barbara Meier1, Deepa Mohanan1, Rebekka Schairer2, Phil Cheng1, Takashi K. Satoh1, Margot Thome2, Emmanuel Contassot1 Lars E. French1 1. University Hospital of Zürich  2. University of Lausanne, Epalinges, Switzerland 345.00 SUBCELLULAR POSITIONING OF INNATE IMMUNE SENSORY PROTEINS IS IMPORTANT FOR THEIR FUNCTIONS. Katherine Barnett1,2, Jonathan Kagan1,2 1. Harvard University, Boston, Massachusetts, USA  2. Boston Children’s Hospital, Boston, Massachusetts, USA 347.00 CD14 AND P38 MAPK IN MONOCYTES MEDIATE PARACRINE TNF-DEPENDENT LYMPHOCYTE ACTIVATION BY E. COLI Corinna Lau1, Dorte Christiansen1, Terje Espevik2, Tom Eirik Mollnes1,2,3,4 1. Research laboratory, Nordland Hospital Trust, Bodø, Norway  2. Center of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway 3. Faculty of Health Sciences, K.G. Jebsen TREC, University of Tromsø, Tromsø, Norway 4. Department of Immunology, Oslo University Hospital, and University of Oslo, Oslo, Norway 348.00 ROLE OF SOCS PROTEINS IN HELICOBACTER PYLORI-INFECTED HUMAN DENDRITIC CELLS Muamera Sarajlic1, Theresa Neuper1, Gernot Posselt1, Silja Wessler1, Jutta Horejs-Hoeck1 1. University of Salzburg 

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349.00 LTB4 IS CRUCIAL FOR α-DEFENSIN-1 PRODUCTION DURING PULMONARY INFECTION WITH ACHROMOBACTER XYLOSOXIDANS Lúcia Helena Faccioli1, Morgana Kelly B. Prado1, Gisele A. Locachevic1, Karina F. Zoccal1, Caroline Fontanari1, Priscilla A.T. Pereira1, Luiz Gustavo Gardinassi1, Simone G. Ramos2 Carlos A. Sorgi1 Ana Lucia C Darini1 1. Faculdade De Ciências Farmacêuticas De Ribeirão Preto - USP  2. Faculdade de Medicina de Ribeirão Preto - USP 350.00 IL-36γ IS A BROAD SENSOR OF PATHOGEN-DERIVED PROTEASE ACTIVITY AND FUNCTIONS AS A GLOBAL ALARMIN IN EPITHELIAL TISSUES Joseph Ainscough1, Tom Macleod1, Sara Gogo2, Adeonuola Alase1, Paul Bowyer2, Michel Monod3, Miriam Witmann1, Martin Stacey1 1. University of Leeds  2. University of Manchester 3. Lausanne University Hospital 351.00 INFLUENZA A VIRUS INFECTION IMPACTS INTESTINAL MICROBIOTA DYNAMICS AND CAUSES QUANTITATIVE ENTERIC DYSBIOSIS Soner Yildiz1, Beryl Mazel-Sanchez1, Matheswaran Kandasamy2, Balaji Manicassamy2, Mirco Schmolke 1 1. University of Geneva  2. University of Chicago 352.00 MYD88-MEDIATED RESPONSES ARE CRITICAL FOR THE IMMUNE SURVEILLANCE PREVENTING THE GUT-LIVER-BRAIN INFLAMMATORY INTERACTION Sang Rhee1, Alexandra Seelmann1, Jonathon Mitchell1, Su Jin Kim2, Eunok Im2 1. Oakland University, Rochester, Michigan, USA  2. Pusan National University, Busan, South Korea 353.00 AHR MONITORS BACTERIAL QUORUM SENSING AND INFECTION DYNAMICS Pedro Moura-Alves1, Anne Stinn1,2,3, Andreas Puyskens1, Marion Klemm1, Ute Guhlich-Bornhof1, Anca Dorhoi1, Jens Furkert4, Annika Kreuchwig4, Laura Lozza1, Gang Pei1, Anne Diehl4, Philippe Saikali1, Carolina Perdomo1, Hans J. Mollenkopf 1, Robert Hurwitz1, Frank Kirschhoefer5, Gerald Brenner-Weiss5, January Weiner 3rd 1, Michael Kolbe 1.2,3, Hartmut Oschkinat4, Gerd Krause4, Stefan H.E. Kaufmann1 1. Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany. 2. Center for Structural Systems Biology, Hamburg, Germany. 3. Helmholtz Centre for Infection Research, Braunschweig, Germany. 4. Leibniz-Institut for Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125 Berlin, Germany. 5. Institute of Functional Interfaces, Karlsruhe Institute of Technology, Karlsruhe, Germany.

87

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MISCELLANEOUS

Posters

354.00 MODULATION OF ANTI-TUMOR, CD8-MEDIATED IMMUNE RESPONSE BY GENETICALLY MODIFIED INFECTIOUS AGENTS DEPENDS ON RIPK3 AND CASPASE-1 Gustavo Amarante-Mendes1, Aamir Rana1, Felipe C. De Almeida1, Henry Paico Montero1, Maryanne Gonzales-Carazas1, Karina R. Bortoluci2 1. Instituto De Ciencias Biomedicas/Universidade De Sao Paulo  2. Departamento de Ciências Biológicas - Universidade Federal de São Paulo 355.00 IN VITRO METABOLIC RESPONSES OF MACROPHAGES TO DIFFERENT NANOPARTICLES: INSIGHTS FROM NMR METABOLOMICS Iola F. Duarte1, Raquel Saborano1, Thidarat Wongpinyochit2, John D. Totten2, Blair F. Johnston2, F. Philipp Seib2 1. Universidade de Aveiro, Aveiro, Portugal  2. University of Strathclyde, Glasgow, UK 356.00 INNATE MEMORY TRAINING OF DERMAL MACROPHAGES INCREASES RESISTANCE TO STAPHYLOCOCCUS AUREUS INFECTION. Reinhild Feuerstein1, Aaron Forde1, Philipp Henneke1,2 1. Center for Chronic Immunodeficiency, University Medical Center, Freiburg  2. Center for Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany 357.00 EXPOSURE OF NEUTROPHIL EXTRACELLULAR TRAPS (NETS) TO WOUND-ASSOCIATED PROTEASES DYNAMICALLY MODIFIES THE ‘NETOME’ Chun Hwee Lim1,2, Sunil Shankar Adav1,3, Siu Kwan Sze3, Artur Schmidtchen1,4 1. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore  2. NTU Institute for Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, Singapore 3. School of Biological Sciences, Nanyang Technological University, Singapore 4. Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Lund, Sweden 358.00 INFLUENCE OF TLR AND INFLAMMASOME SIGNALLING ON THE CHAPLE SYNDROME SEVERITY SPECTRUM Goksu Gokberk Kaya1, Muzaffer Yildirim1, Ahmet Ozen2, Sinan Sari3, Buket Dalgic3, Ihsan Gürsel1 1. Bilkent Univeristy  2. Marmara University 3. Gazi University

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362.00 MICROGLIAL DERIVED IL-1 DRIVES A PROTECTIVE MYELOID RESPONSE AFTER INTRACEREBRAL HAEMORRHAGE Jack Barrington1, Jack Rivers-Auty1, Adrian Parry-Jones1, Stuart Allan1, David Brough1 1. University Of Manchester  363.00 CD109 IS A CELL-EXTRINSIC REGULATOR OF CUTANEOUS IL-17 PRODUCING γΓ δT CELLS Hualin Zhang1, Giustino Carnivale1, Barbara Polese1, Ghislaine Fontes1, Irah L. King1 1. McGill University Health Centre  364.00 CYTOMEGALOVIRUS REPROGRAMS MACROPHAGES FACILITATING VIRAL DISSEMINATION Sebastian Baasch1, André Riedl2, Zsolt Ruzsics2, Hartmut Hengel2, Philipp Henneke1,3 1. Center for Chronic Immunodeficiency, University Medical Center, Freiburg, Germany  2. Institute of Virology, University Medical Center, Freiburg, Germany 3. Center for Pediactrics and Adolescent Medicine, University Medical Center, Freiburg, Germany 365.00 A DNA VIRUS INHIBITS THE NF-kB PATHWAYS IN DROSOPHILA Cara West1, Donald Gammon2, Florentina Rus1, Neal Silverman1 1. Division of Infectious Diseases and Immunology, Department of Medicine; Program in Innate Immunity; University of Massachusetts Medical School, Worcester, MA U.S.A 2. University of Texas Southwestern Medical Center, Dallas, TX U.S.A

89

Posters

359.00 INHIBITION OF PRO-ATHEROGENIC GENE EXPRESSION BY MULTI-STAT TARGETING COMPOUNDS AS A NOVEL TREATMENT STRATEGY OF CVD Martyna Plens-Galaska1, Malgorzata Szelag1, Aida Collado2, 3, Patrice Marques2, 3, Susana Vallejo4, 5 , Mariella Ramos-González4, 5, Joanna Wesoly1, Maria Jesus Sanz2, 3 Concepción Peiró4, 5 Hans Bluyssen1 1. Adam Mickiewicz University, Poznan, Poland  2. University of Valencia, Valencia, Spain 3. University Clinic Hospital of Valencia, Valencia, Spain 4. Universidad Autónoma de Madrid, Madrid, Spain 5. Universitario La Paz, Madrid, Spain   361.00 IDENTIFICATION OF A POTENTIAL INHIBITOR OF THE PROTEASOME ACTIVITY INDUCED BY LPS Yisett González1, Deborah Doens1, Hector Cruz1,2, Ricardo Santamaría1, Marcelino Gutierrez1, Alejandro Llanes1, Patricia L. Fernández1 1. Instituto De Investigaciones Científicas Y Servicios De Alta Tecnología  2. Universidad Latina de Panamá

Posters

366.00 DECIPHERING THE MICROBIOME AND METABOLIC FACTORS CONTRIBUTING TO PROTECTION AGAINST ULCERATIVE COLITIS Joana Gaifem1,2, Maria Jose Garzón3,4, Carles Ubeda3,4, Luis Gafeira Gonçalves5, Egidio Torrado1,2, Cristina Cunha1,2, Agostinho Carvalho1,2, Margarida Saraiva6,7 António Gil Castro1,2 Ricardo Silvestre1,2 1. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal  2. ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal 3. Departamento de Genómica y Salud, Centro Superior de Investigación en Salud Pública – FISABIO, Valencia, Spain 4. Centers of Biomedical Research Network (CIBER) in Epidemiology and Public Health, Madrid, Spain 5. Instituto de Tecnologia Química e Biológica (ITQB) António Xavier, Universidade NOVA, Oeiras, Portugal 6. i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal 7. IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal 367.00 FREQUENTLY USED BIOINFORMATIC TOOLS OVERESTIMATE THE DAMAGING EFFECT OF ALLELIC VARIANTS Line Andersen1, Ewa Terczynska-Dyla1, Nanna Mørk2, Veit Hornung3, Mette Christiansen2, Trine Mogensen2, Rune Hartmann1 1. Aarhus University, Aarhus, 8000, Denmark  2. Aarhus University Hospital, 8200, Aarhus, Denmark; 3. Ludwig-Maximilians-Universität München, Munich, 81377, Germany. 368.00 HUMAN ADIPOSE DERIVED-MESENCHYMAL STEM CELLS SWITCH OFF MACROPHAGE PHENOTYPIC MARKERS Carolina Ferreira1, 2, Tírcia Santos2, 3, Inês Mesquita1, 2, Mariana Cerqueira2, 3, Ricardo Silvestre1, 2, Rui Reis2, 3 1. Life Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal  2. ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal 3. B’s Research Group-Biomaterials, Biodegradables, and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal 369.00 INFLAMMATION AT THE UTERINE WALL LINING IN PREGNANCY. Gabriela Silva1, 2, 3, Guro Stødle1, 2, 3, Lobke Gierman1, 2, Siv Mundal1, 2, Mattijs Elschot2, Karin Collett4, Ingunn Nervik5, Unn Elin Dahlberg3 Line Bjørge4, 5 Marie Aune2 1. Norwegian University of Science and Technology (NTNU), Trondheim, Norway  2. Centre of Molecular Inflammation Research, Trondheim, Norway 3. St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway 4. Haukeland University Hospital, Bergen, Norway 5. Cellular & Molecular Imaging Core Facility, Trondheim, Norway 6. University of Bergen, Bergen, Norway

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372.00 HEME INDUCED INNATE IMMUNE MEMORY Elisa Jentho1,2, Boris Novakovic3, Hank G. Stunnenberg3, Franziska Röstel1,2, Joel Guerra1,2, Mihai G. Netea3, Michael Bauer1,2, Sebastian Weis1,2 1. Universitätsklinikum Jena, Germany  2. Center for Sepsis Control and Care, Jena, Germany 3. Medical Centre and Radboud University, Nijmegen, Netherlands   373.00 IL-10 OUTSIDE THE HEMATOPOIETIC SYSTEM: A NEW ROLE ON SKIN CELLS AGEING Ana Raquel Maceiras1, 2, Ana Catarina Martins1, 2, Ana Cardoso1, 2, 3, Ana Rocha1, 2, Joana C. Macedo1, 2 , Gil Castro4, 5, Isabel Castro4, 5, Paulo Vieira3 Elsa Logarinho1, 2 Margarida Saraiva1, 2 1. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal  2. IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal 3. Institut Pasteur, Paris, France 4. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal 5. ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal 374.00 THE INFLUENCE OF IFNL4 SINGLE NUCLEOTIDE POLYMORPHISMS ON IFNL3 EXPRESSION Michelle Møhlenberg1, Ewa Terczyńska-Dyla1, Nanna H. Hansen1, Karen-Louise Thomsen2, Henning Grønbæk2, Yonglun Luo1, Rune Hartmann1 1. Aarhus University  2. Aarhus University Hospital 375.00 CHRONIC INFLAMMATION INVERTS CD200R SIGNALING AND PERPETUATES TYPE I IMMUNE RESPONSES Ines Ramos1, Michiel van der Vlist1, Luuk van den Hoogen1, Christian Widmann2, Robert Lebbink1, Sanne Hiddingh1, Floor Peters1, Ruth Fritsch-Stork3 Timothy Radstake1 Linde Meyaard1 1. UMC Utrecht, Utrecht, Netherlands  2. University of Lausanne, Lausanne, Switzerland 3. Lugwig Boltzmann Institute of osteology, Vienna, Austria

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Posters

370.00 DISSECTING THE ROLE OF DAMPS IN NECROPTOSIS-MEDIATED INFLAMMATION Francesca Pinci1, Moritz Gaidt1, Veit Hornung1 1. Ludwig-Maximilians-Universität Munich    371.00 GANODERMA FORMOSANUM POLYSACCHARIDES ENHANCE ANTITUMOR IMMUNE RESPONSES AND DOWNREGULATE IMMUNOSUPPRESSIVE CELLS IN TUMOR-BEARING MICE Chun-Jen Chen1, Jhe-Yu Yang 1 1. National Taiwan University 

Posters

376.00 THE INTERPLAY BETWEEN IMMUNITYAND BRAIN: THE ROLE OF IRON IN NEURODEGENERATIVE DISEASES Ana-Catarina Martins1, Illyane Sofia Lima1, Inês Pereira1, Antonino Kapitão1, Gracelino Martins1, Raffaella Gozzelino1 1. CEDOC/ NOVA Medical School  377.00 ROLE OF SICKLE RED CELL IN TOLL-LIKE RECEPTORS GENE EXPRESSION IN HUMAN MONONUCLEAR CELLS Thassila Nogueira1,2, Sanzio Santana1, Dalila Zanette1, Carolina da Guarda1, Rayra Santiago1, Corynne Adanho1, Vitor Maffili1, Valma Lopes3 Ricardo Riccio1 Marilda Gonçalves1,4 1. Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz – FIOCRUZ/BA  2. Universidade Católica do Salvador (UCSAL) 3. Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA) 4. Universidade Federal da Bahia. Faculdade de Farmácia (UFBA-FACFAR) 378.00 OVERSTIMULATION OF COLONIC TLR-4 WITH LPS DOES NOT INDUCE VISCERAL HYPERSENSITIVITY IN RATS Sergio López-Estévez1, Vicente Martínez1 1. Universitat Autònoma De Barcelona  379.00 IAPS REGULATE DISTINCT INNATE IMMUNE PATHWAYS TO CO-ORDINATE THE RESPONSE TO BACTERIAL PEPTIDOGLYCANS Che Stafford1,2, Kate Lawlor2, Valentin Heim2, Aleksandra Bankovacki2, Jonathan Bernardini2, John Silke2, Ueli Nachbur2 1. Ludwig Maximilian University, Munich, Germany  2. Walter and Eliza Hall Institute, Melbourne, Australia 380.00 DIFFERENT TLR SIGNALLING PATHWAYS INDUCE MACROPHAGES OR NEUTROPHILS WITH ANTI-TUMOUR FUNCTIONS IN VIVO Raquel Lopes1, Miguel Pinto1, Sofia Mensurado1, Hiroshi Kubo2, Bruno Silva-Santos1, Karine Serre1 1. Instituto De Medicina Molecular - Joao Lobo Antunes  2. Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan 381.00 REGULATION OF SCAVENGER RECEPTOR SR-BI IN THE PLASMA MEMBRANE BY MULTIMERIZATION AND RETENTION Pedro Elias Marques1, Steffen Nyegaard1, Richard Collins1, William Trimble1, Sergio Grinstein1 1. The Hospital for Sick Children, Toronto, Canada 

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383.00 CIRCULATING SERUM AMYLOID, A IS ELEVATED IN MINK KITS SUFFERING FROM PREWEANING DIARRHEA Ronja Mathiesen1, Bettina Nonnemann 1, Julie Melsted Birch2, Mariann Chriél1, Tina Struve3, Henrik Elvang Jensen2, Jens Frederik Agger2, Peter Mikael Helweg Heegaard1 1. Technical University of Denmark, Kgs. Lyngby, Denmark  2. University of Copenhagen, Frederiksberg C, Denmark 3. Kopenhagen Fur, Glostrup, Denmark   384.00 PHOSPHOCHOLINE MODIFIED DENDRIMERS TUNE THE IMMUNE ACTIVITY OF C-REACTIVE PROTEIN Peter M. H. Heegaard1, 2, Ulrik Boas1, Mohammad Daoud1, Sebastian Meier3, Kristoffer Gehring1, Tobias Hansen1, Ditte Juhl Mogensen1 1. Technical University of Denmark, National Veterinary Institute  2. Technical University of Denmark, Department of Bioengineering 3. Technical University of Denmark, Department of Chemistry 385.00 HY380 INCREASES THE NUMBER OF MYELOID-DERIVED SUPPRESSOR CELLS THAT AMELIORATE SEPSIS IN MICE Sooghee Chang1, Youn-Hee Kim1, Young Woo Kim1, Kyoung Sun Park2, Sang Beum Lee2, SeungHyeok Seok1,3, Nam-Hyuk Cho1,2, Murim Choi1 Nagahiro Minato4 Seung-Yong Seong1,2 1. Seoul National University, Seoul, Korea  2. Wide River Institute of Immunology, Hongcheon, Gangwon, Korea 3. Seoul National University Hospital, Seoul, Korea 4. Kyoto University, Kyoto, Japan 386.00 MYELOID PTEN PROMOTES OBESITY-INDUCED INSULIN RESISTANCE Andrea Vogel1, Julia Stefanie Brunner1, Alexander Lercher2, Mario Kuttke1, Ana Korosec2,3, Anastasiya Hladik2,3, Hannah Paar1, Omar Sharif3,4 Gernot Schabbauer1 1. Medical University Vienna, Institute for Vascular Biology and Thrombosis Research, Vienna, Austria  2. CeMM Research Center Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria 3. Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria 4. Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria

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Posters

382.00 ACTIVATION STATE OF EPITHELIA RESIDENT T LYMPHOCYTES Spela Konjar1,2, Ulrika Frising2, Cristina Ferreira1,2, Reinhard Hinterleitner3, Toufic Mayassi3, Qifeng Zhang2, Birte Blankenhaus1, Nejc Haberman4 Yunhua Loo2 Marc Veldhoen1,2 1. Instituto De Medicina Molecular, Portugal  2. Babraham Institute, UK 3. University of Chicago, USA 4. UCL, London, UK

Posters

387.00 FERRITIN CONTROLS THE FUNCTIONAL INTEGRITY OF REGULATORY T CELLS Faouzi Braza1, Eloy Cuadrado2, Brendon Scicluna3, Patricia Amador1, José Silva1, Sebastian Weis4, Birte Blankenhaus1, Jocelyne demengeot1 Derk Amsen2 Miguel Soares1 1. Instituto Gulbenkian De Ciência  2. Sanquin Research and Landsteiner Laboratory AMC/UvA 3. Center for Experimental Molecular Medicine and Academic Medical Center 4. Center for Sepsis Control and Care, Universitätsklinikum Jena 388.00 BISPHENOL A ENHANCES BAFF EXPRESSION IN MACROPHAGES BY THE INCUBATION WITH FIBROBLAST-LIKE SYNOVIOCYTES Sang-Hyuck Lee1, Sung-Sik Yoon1, Eun Yi Moon1 1. Sejong University  389.00 BAX/BAK-INDUCED APOPTOSIS RESULTS IN CASPASE-8 DEPENDENT IL-1β MATURATION IN PRIMARY MACROPHAGES D. Chauhan1, E. Bartok2, M.M. Gaidt1, J. Hermann3,6, J.M. Seeger4, P. Broz5, R. Beckmann1, H. Kashkar4 R. Müller3,6 V. Hornung1 1. Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Bayern, Germany  2. Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, NRW, Germany 3. Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre For Infection Research and Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany 4. Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), CECAD Research Center, University of Cologne, NRW, Germany 5. Department of Biochemistry, University of Lausanne, Epalinges, Switzerland 6. German Center for Infection Research (DZIF), Partner Site Hannover - Braunschweig, Germany 390.00 ROLE OF A NOVEL TRANSPORTER SLC46A3 IN MAINTENANCE OF INTESTINAL INTEGRITY Anubhab Nandy1, Amanda Monahan1, Kendi Okuda1, Michelle Kontoff1, Neal Silverman1 1. Department of Medicine, University of Massachusetts Medical School, Worcester, MA,USA

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