Scientific Program Table of contents

Scientific Program Table of contents Keynote Lecture-----------------------------------------------------------------2 Antony Leong Memorial Lecture--...
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Scientific Program Table of contents Keynote Lecture-----------------------------------------------------------------2 Antony Leong Memorial Lecture--------------------------------------------------2 Biomedicine----------------------------------------------------------------------2 Breast Pathology----------------------------------------------------------------4 Cytopathology ------------------------------------------------------------------5 Dermatopathology (1)---------------------------------------------------------5 Dermatopathology (2)---------------------------------------------------------6 Forensic Medicine--------------------------------------------------------------7 Gynecopathology---------------------------------------------------------------8 Hematopathology--------------------------------------------------------------9 Liver Pathology------------------------------------------------------------------9 Lung Pathology-----------------------------------------------------------------10 Liquid Biopsy -------------------------------------------------------------------11 Molecular Pathology ---------------------------------------------------------12 Molecular Technology Update ---------------------------------------------13 Neuropathology----------------------------------------------------------------14 Novel Targets in Diseases----------------------------------------------------15

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(9:30—10:30, Dec. 10, 2016) Keynote Lecture Yun Yen, MD.,PhD. President, Taipei Medical University, Taiwan Topic: Bile Duct Cancer in Asia (11:00—12:00, Dec. 10, 2016) Antony Leong Memorial Lecture Robert Y Osamura, MD., PhD. Professor, International University of Health and Welfare(IUHW) Graduate School, Japan Topic: “Molecular Immunohistology” in Genomic Era

S1 Biomedicine (9:00—17:30, Dec. 09, 2016) (9:00am-12:30noon) James Wang (王乾基), PhD. Professor, CEO at Trican Biotechnology Co.,Ltd., V.P. R&D at Global BioPharma,Inc., Taiwan Topic: Future of Medicine –Therapeutic Monoclonal Antibodies Suh-Chin Wu (吳夙欽), PhD. Professor, Institute of Biotechnology, National Tsing Hua University, Taiwan, Department of Medical Science, National Tsing Hua University, Taiwan Topic: Dendritic cell activation by influenza hemagglutinin glycoproteins and its implications for vaccine development Ching-Chuan Kuo (郭靜娟), PhD. Associate Investigator, Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes, Taiwan Topic: Modulation of indoleamine 2,3-dioxygenase, an immuno-oncology target , for cancer therapeutics Ying-Jan Wang (王應然), PhD. Professor, Department of Environmental and Occupational Health College National Chen Kung University, Taiwan Topic: ER stress triggered autophagy may contribute to the enhanced immune response of nanoparticles in an allergic contact dermatitis animal model induced by chromium (VI) Yuan-Soon Ho(何元順), PhD. Professor, Graduate Institute of Sciences, College of Medicine, Taipei Medical University, Taiwan 2

Topic: Studies on the mechanisms of histamine N-methyltransferase (HNMT)- mediated Herceptin® drugresistance in breast cancer cells Bu-Miin Huang (黃步敏), PhD. Professor, Department of Cell Biology and Anatomy College of Medicine, National Cheng Kung University, Taiwan Topic: Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways (14:00-17:30) Min-Hsiung Pan (潘敏雄), PhD. Professor, Institute of Food Science and Technology, National Taiwan University, Taiwan Topic: Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)epicatechin-3- gallate in LPS-induced macrophages and endotoxemia Tsung-Hsien Chuang (莊宗顯), PhD. Associate Investigator, Immunology Research Center, National Health Research Institutes, Taiwan Topic: Role of Toll-like receptors in initiation of inflammatory and oncological diseases Yun-Jin Jiang (江運金), PhD. Associate Investigator, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan Topic: GON4L is Required for DNA Replication by Regulating CDC6 Expression and Participating in Prereplication Complex Formation Yi-Rong Chen (陳怡榮), PhD. Associate Investigator, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan Topic: The biochemical effects and clinical implications of VHR/DUSP3 deficiency in lung cancer development Jun-Yang Liou (劉俊揚), PhD. Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Taiwan Topic: 14-3-3 proteins contribute to tumor progression of hepatocellular carcinoma Neng-Yao Shih (施能耀), PhD. Associate Investigator, National Institute of Cancer Research, National Health Research Institutes, Taiwan Topic: Immuno-Targeting ENO1 as A Novel Strategy for Cancer Therapy

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S9 Breast Pathology (9:00-17:30, Dec.11, 2016) (9:00am-12:30noon) Rin Yamaguchi, MD., PhD. Associate Professor, Department of Pathology & Laboratory Medicine, Kurume University Medical Center, Fukuoka, Japan Topic: DCIS subtypes and TILs Puay Hoon Tan, MBBS, FRCPA, FAMS, MD, FRCPath, MIAC. Senior Consultant Histopathologist and Head, Department of Pathology, Singapore General Hospital, and Academic Chair of the SingHealth-Duke NUS Pathology Academic Program, Singapore Topic: Updates in breast fibroepithelial tumours Yunn-Yi Chen, MD., PhD. Professor of Clinical Pathology, University of California, San Francisco, USA Topic: Correlation of genotype and phenotype in breast cancer Gary M.K. Tse, MBBS (HK), FRCPC, FCAP, Dip Am Bd AP, MIAC Senior Medical officer of the Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China Topic: Update on biomarkers of breast pathology (14:00-17:30) Wei-Wu Chen (陳偉武), MD. Attending physician, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan Topic: Precision Medicine in Breast Cancer Chi-Kuan Chen (陳冀寬), MD.,PhD. Director, Molecular Diagnostics R&D, Department of Laboratory Medicine, Mackay Memorial Hospital, Taipei, Taiwan Topic: Genomics in breast cancer Cheng-Ping Yu (于承平), MD.,PhD. Associate Professor, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Topic: The evolution of breast cancer classification toward precision medicine Tsun-Hou Chang (張尊厚), MD. Director, Women’s Health Center, Tri-Service General Hospital, Taipei, Taiwan Topic: Case presentation for radio-pathologic inconsistence in BIRAD category 4 Chih-Yi Hsu (許志怡), MD. Director of General Pathology, Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan Topic: The determination of pathological complete response in breast cancer Chih-Jung Chen (陳志榮), MD.,PhD. Director, Division of Molecular Diagnosis, Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan Topic: Liquid biopsy in breast cancer diagnosis and therapeutic response monitor 4

S11 Cytopathology (9:00am-12:30noon, Dec.11, 2016) (09:00-09:18) Chiung-Ru Lai (賴瓊如), MD. Section Chief, Department of Pathology, Taipei Veterans General Hospital Topic : Uncommon Variant of Papillary Thyroid Carcinoma (9:19-9:36) Chien-Chin Chen (陳建欽), MD. Attending Physician, Ditmanson Medical Foundation Chia-Yi Christian Hospital,Taiwan Topic : Thyroid Fine Needle Aspiration : a poorly differentiated neoplasm (9:37-9:54) Yeh-Han Wang (王業翰), MD. Attending Physician, Department of Anatomic Pathology, Keelung Hospital, Ministry of Health and Welfare, Taiwan Topic : The Cytological Features of Mammary-Analogue Secretory Carcinoma (MASC) in Salivary Gland Fine Needle Aspiration (FNA) : A Case Report and Literature Review (9:55-10:12) Chih-yi Liu (劉之怡), MD. Attending Pathologist, Division of pathology, Sijhih Cathay General Hospital Topic: EBV-positive lymphoepithelioma-like thyroid carcinoma: report of a case with cytologic and histologic correlation (10:13-10:30) Jie-Yang, Jhuang (莊傑仰), MD. Attending physician, Department of Anatomic Pathology, Mackay Memorial Hospital Topic : Metastatic Merkle cell carcinoma in urine (11:00-11:45) Aileen Wee, MB,BS, FRCPath, FRCPA Professor of Pathology and Senior Consultant, National University of Singapore, Singapore Topic: Liver fine needle aspiration (11:45-12:30) Rin Yamaguchi, MD., PhD. Associate Professor, Department of Pathology & Laboratory Medicine, Kurume University Medical Center, Fukuoka, Japan Topic: Papillary lesions in Breast FNA

S7 Dermatopathology (14:00-17:30, Dec.10, 2016) (14:00-14:30) Suat Hoon Tan, MD. Director and Professor, National Skin Center, Singapore 5

Topic: Acral melanoma – Asian aspect (14:30-15:00) Dong Youn Lee, MD. Professor, Department of Dermatology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea Topic: Subungual melanoma (15:00-15:30) Yu-Hung Wu (吳育弘), MD. Assistant Professor, Department of Medicine, Mackay Medical College, Taiwan Topic: Problematic seborrheic keratosis (16:00-16:30) Jie-Yang Jhuang (莊傑仰), MD. Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan Topic : Immunohistochemistry in cutaneous lymphoma (16:30-17:00) Julia Yu-Yun Lee (李玉雲), MD. Director and Professor, Department of Dermatology, National Cheng Kung University, Taiwan Topic: 10-year experience of cutaneous lymphoma

S15 Dermatopathology (9:00-17:30, Dec. 11, 2016 ) Slide Seminar (9:30am-12:30noon) (9:30-10:00) Yu-Hung Wu (吳育弘), MD. Assistant Professor, Department of Medicine, Mackay Medical College, Taiwan Topic: Cutaneous vascular tumor (10:00-10:30) Cheng-Hsiang Hsiao (蕭正祥), MD. Director and Associate Professor, Department of Pathology, Cheng Hsin General Hospital, Taipei, Taiwan Topic: Skin adnexal tumor (11:00-11:30) Dong Youn Lee, MD. Professor, Department of Dermatology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea Topic: Subungual melanoma (11:30-12:00) Suat Hoon Tan, MD. Director and Professor, National Skin Center, Singapore Topic: Cutaneous T cell lympgoma Self-assessment case discussion (14:00-17:30) 6

(14:00-14:30) Cheng-Hsiang Hsiao (蕭正祥), MD. Director and Associate Professor, Department of Pathology, Cheng Hsin General Hospital, Taipei, Taiwan Topic: Case 1-5 (14:30-15:00) Kuo-Hsien Wang (王國憲), MD. Associate Professor, Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan Topic: Case 6-10 (15:00-15:30) Hong-Wei Gao (高鴻偉), MD. Director, Division of Surgical Pathology, Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan Topic: Case 11-15 (16:00-16:30) Chi-Shun Yang (楊啟順), MD. Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan Topic: Case 16-20 (16:30-17:00) Szu-Ying Chin (金思穎), MD. Department of Dermatology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan Topic: Case 21-25 (17:00-17:30) Jie-Yang Jhuang(莊傑仰), MD. Department of Pathology, Mackay Memorial Hospital Taipei, Taiwan Topic: Case 26-30

S4 Forensic Medicine (14:00-17:30, Dec.9, 2016) Adrian Linacre, BSc., PhD. Professor of Forensic Biology, School of Biological Sciences, Flinders University, Australia Topic: Role of Massively Parallel DNA Sequencing in Forensic Science William Goodwin, PhD. Reader (Professor) in Forensic Genetics, School of Forensic and Applied Sciences, University of Central Lancashire, Preston, UK Topic: Advances in Human Remains Identification Hsiao-Lin Hwa (華筱玲), MD.,PhD. Director and Associate Professor, Department of Forensic Medicine, College of Medicine, National Taiwan University, Taiwan Topic: SNP analysis for individual identification James Chun-I Lee (李俊億), PhD. 7

Professor, Department of Forensic Medicine, College of Medicine, National Taiwan University, Taiwan Topic: STR sequence searching in massively parallel sequencing Huiyuan Niu (牛慧媛), MSc.

Sequencing Specialist, Illumina China - Beijing Branch, China Topic: Applications of MiSeq FGx in Forensic Science

S13 Gynecopathology (14:00-17:30, Dec.11, 2016) (14:00-14:50) Ie-Ming Shih (施益民), MD., PhD. Richard W. TeLinde Distinguished Professor, Department of Gynecology and Obstetrics, and Professor, Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, USA Topic: Molecular Genetic Landscape of Endometriosis - a time to re-define what is cancer? (14:50-15:10) Chang-Che Wu (吳長哲), MD. Resident, Department of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Topic : Case Presentation: Uterine myeloid sarcoma (15:10-15:30) Gog-Kai Huang (黃恭愷), MD. Clinical Fellow, Department of Pathology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan Topic : Case Presentation: High-grade endometrial stromal sarcoma (16:00-16:30) Chiung-Ru Lai (賴瓊如), MD. Director, Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan Topic: Glandular lesions in Pap smear (16:30-17:00) Kuan-Ting Kuo (郭冠廷), MD. Associated professor, Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan Topic : Müllerian adenosarcoma : an intriguing puzzle (17:00-17:30) Pao-Shu Wu (吳保樹), MD.,PhD. Assistant Professor, Department of Pathology, MacKay Memorial Hospital, Taipei, Taiwan Topic : Immunohistochemical and molecular analysis of ovarian sclerosing stromal tumor

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S6 Hematopathology (14:00-17:30, Dec.10, 2016) (14:00-14:45) Andrew C. Wotherspoon, MB, BCh, FRCPath Professor, Department of Histopathology, Royal Marsden Hospital, London, UK President, European Association for Haematopathology Topic: Primary Splenic Small B-cell lymphomas (14:45-15:30) Ming-Qing Du, MD., PhD. Professor, Department of Pathology, Cambridge Cancer Center, University of Cambridge, Cambridge, U.K. Topic: SMZL: novel molecular insights by exome sequencing (16:00-16:45) Philippe Gaulard, MD. Professor, Department of Pathology, University Hospital Henri Modor of Créteil, France Topic: AITL and PTCL-NOS: emerging biomarkers in diagnosis (16:45-17:30) Leticia Quintanilla-Fend, PhD., Dr.med. Professor, Institute of Pathology, University Hospital Tübingen, Eberhard-Karls-University of Tübingen, Tübingen, Germany Topic: EBV associated T/NK LPD: updates in diagnosis

S8 Liver Pathology

(14:00-17:30, Dec.10, 2016)

Young Nyun Park, MD., PhD. Chairman, Avison Distinguished Professor, Department of Pathology, Yonsei University College of Medicine, Seoul, Korea Topic: HCC with stemness and tumor microenvironment Aileen Wee, MB,BS, FRCPath, FRCPA Professor of Pathology and Senior Consultant, National University of Singapore, Singapore Topic: Mimics of Hepatocellular carcinoma Wilson Man-shan Tsui (崔文山), MD., FRCPath Chief of Service, Department of Pathology, Caritas Medical Centre, Hong Kong, China Topic: Combined hepatocellular- cholangiocarcinoma Matthew M. Yeh, MD., PhD. Professor, Department of Pathology, University of Washington School of Medicine, Seattle, USA Topic: Fatty liver and fatty liver tumor: do they occur together? Lihong Chen (陳麗紅), MD. 9

Director, Department of Pathology, Mengchao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, China Topic: Case presentation Julintorn Somran, MD. Assistant Professor, Department of Pathology, Naresuan University, Phitsanulok 65000, Thailand Topic: Case presentation Yi-Chen Yeh(葉奕成), MD. Department of Pathology, Taipei Veteran General Hospital, Taipei, Taiwan Topic: Case presentation Hui-Ting Hsu (許惠婷), MD. Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan Topic: Case presentation

S12 Lung Pathology (8:30-17:30, Dec.11, 2016) Neoplastic section (8:30am—12:30 noon) (8:30am-9:00am) Masayuki Noguchi, MD., PhD. Professor, Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan Topic: Genetic and epigenetic abnormalities of early lung adenocarcinoma (9:00am-9:30am) Geon Kook Lee, MD., PhD. Chief Scientist of Lung Cancer Branch, Division of Translational & Clinical Research, National Cancer Center, Ilsan-dong-gu, Gyeonggi-do, Korea Topic: Tumor immunology in Lung cancers (9:30am-10:00am) Yuichi Ishikawa, MD., PhD. Vice Director of The Cancer Institute, Japanese Foundation of Cancer Research, and Head of the pathology division, Tokyo, Japan Topic: PD-L1 expression in lung cancers (10:00am-10:30am) Ka-Fai To, MBChB (CUHK), FRCPA, FHKCPath, FHKAM(Path) Professor and Chairman, Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, China. Topic: Potential Actionable Molecular Alterations in Pulmonary Large Cell Carcinoma (11:00am-11:30am) Shiu-Feng Huang (黃秀芬), MD., PhD. Investigator and Attending physician, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan 10

Topic: The mutation spectrum of the NSCLC in Taiwan and its implications (11:30am-12:00noon) Yasuto Jin, MD., PhD. Professor, Department of Respiratory Medicine, Hiratsuka Kyosai Hospital, Kanagawa, Japan Topic: Targeted therapy and immunotherapy for lung cancer: clinicopathological study (12:00-12:30noon) Yao-tseng Chen (陳耀楨), MD.,PhD. Professor, Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, USA Topic: The Role of Practice Pathologists in the Era of Targeted Therapy and Immunotherapy

Non-neoplastic section (14:00-17:30) (14:00-14:30) Osamu Matsubara, MD., PhD. Professor, Pathology division, The Cancer Institute, Japanese Foundation of Cancer Research, Tokyo, Japan Topic: Update in pulmonary vascular disease 14:30-15:00 Wun-Ju Shieh (謝文儒), MD., MPH, PhD, FCAP, FASCP Senior Medical Officer/Deputy Chief, Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, USA Topic: Pathology of Viral pneumonia 15:00-15:30 Pradeep Vaideeswar, MB, BS, MD. Professor (Additional), Department of Pathology (Cardiovascular & Thoracic Division), Seth G. S. Medical College, Mumbai, India Topic: Congenital lung diseases in adult patients 16:00-16:30 Kun Young Kwon, MD., PhD. Professor, Department of Pathology, Keimyung University Dongsan Medical Center, Daegu, Korea Topic: Smoking-related lung pathology 16:30-17:00 Sonja Klebe, MD., PhD, FRCPA Associate Professor, Department of Anatomical Pathology, Flinders Medical Centre, Adelaide, Australia Topic: Pathology of Asbestosis-related mesothelioma 17:00-17:30 Soon Hee Jung, MD., PhD. Professor, Department of Pathology, Yonsei University, Seoul, Korea Topic: Comparison of asbestos fiber detection methods in BAL fluid and lung tissue

S14 Liquid Biopsy: Changing the Way of Diagnosis for NSCLC patients 11

( 8:50am-12:40 noon, Dec 9, 2016 ) Pan-Chyr Yang (楊泮池) MD., PhD. President, National Taiwan University, Taiwan Topic: Precision Medicine for Lung Cancer Marc G Dennis, PhD. Biochemistry and Molecular Biology at Nantes University Hospital, France Topic: Next-Generation Sequencing (NGS), Digital PCR and qPCR: Technologies for Liquid Biopsy Development Shinichi Toyooka, MD. Professor, Department of Clinical Genomic Medicine, Okayama University Hospital, Okayam, Japan Topic: Our experience of liquid biopsy for lung cancer Wanseop Kim, MD. Department of Pathology, Konkuk University, Seoul, Korea Topic: Experience Sharing of Liquid Biopsy for EGFR Mutation Testing Youngchul Kim, MD., PhD. Lung and Esophageal Cancer Clinic, Department of Internal Medicine, Chonnam National University Hwasun Hospital, Gwangju, Chonnam, Korea Topic: Current clinical practice when the 3rd generation TKIs are available in Korea

S10 Molecular Pathology (9:00-17:30, Dec.11, 2016) (9:00-9:20) I-Chieh Chuang (莊依潔), MD. Staff pathologist, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan Topic:Case study: molecular diagnosis of soft tissue tumor 1 (9:20-9:40) Cher-Wei Liang (梁哲維), MD. Staff pathologist, Department of Pathology, National Taiwan University Hospital, Taiwan Topic:Case study: molecular diagnosis of soft tissue tumor 2 (9:40-10:10) Paul Chih-Hsueh Chen (陳志學), MD., PhD. Staff pathologist, Department of Pathology and Laboratory Medicine, Taipei-Veterans General Hospital, Taiwan Topic:Case study: molecular diagnosis of bone tumor 1 12

(10:10 -10:30) Daichi Maeda, MD.,PhD. Associate Professor, Akita University School of Medicine, Japan. Topics: Case study: Ovarian sex cord-stromal tumor in a patient with Ollier's disease (11:00-11:20) Maki Yoshida, MD. Staff pathologist, Department of Pathology, Tokyo Medical University, Japan Topic: case study: molecular diagnosis of salivary gland tumors (11:20-11:40) Kentaro Inamura, MD., PhD. Staff Scientist, The Cancer Institute Hospital of Japanese Foundation for Cancer Research (JFCR), Japan Topic: Case study: PD-L1 expression in high-grade neuroendocrine carcinoma of the lung (11:40-12:00) Naoki Oishi, MD., PhD. Assistant Professor, Department of Pathology, University of Yamanashi, Japan Topic: Case study: molecular diagnosis of lymphomas

(14:00-17:30) (14:00-14:45) Shih-Chiang Huang (黃士強), MD. Staff pathologist, Department of Anatomical Pathology, Linkou Chang Gung Memorial Hospital, Taiwan Topic: Molecular Pathogenesis of vascular tumors (14:45pm-15:30pm) Jen-Chieh Lee(李仁傑), MD., PhD. Staff pathologist, National Taiwan University Hospital, Taipei, Taiwan Topic: Phosphaturic Mesenchymal Tumors (16:00pm-16:45pm) Chien-Feng Li (李健逢), MD., PhD. Director, Division of Clinical Pathology, Chi Mei Medical Center, Tainan, Taiwan Topic : Targeting Metabolic Transformation for Sarcoma Therapy (16:45pm-17:30pm) Ryohei Katoh, MD., PhD. Professor, Faculty of Medicine Department of Human Pathology, University of Yamanashi, Japan Topic: Recent Progress in Molecular Diagnosis and Therapeutic Aspect of Thyroid Tumor Pathology

S2 Molecular Technology Update (9:00am-12:00 noon, Dec.09, 2016) Weei-yuarn Huang(黃緯元) MD., PhD. Associate Professor, Department of Pathology, Faculty of Medicine, Dalhouse University, Nova Scotia, Canada Topic: Genome-Wide Copy Number Alterations in Colonic Mixed Adenoneuroendocrine Carcinoma 13

(MANEC) ChiKuan Chen(陳冀寬) MD., PhD. Director, Molecular Diagnostics R&D, Department of Laboratory Medicine, Mackay Memorial Hospital, Taipei, Taiwan Topic: From Probe to Decode Eugene (Seong-Youl) Kim, PhD. Director, Academic Affair & Marketing Department, Seegene Inc., Seoul, Korea Topic: Cutting-edge Real-time PCR Technologies in Molecular Diagnostics Mengchu Wu(吳夢楚), PhD. Director of Application Development, Personal Genomics, Taiwan Topic: Next-generation sequencing applications for liquid biopsy cancer research Shu-Jen Chen(陳淑貞), PhD. Chief Scientific Officer, ACT Genomics Co., Ltd. Taiwan Topic: Cancer Genomics and Immune Therapy

S5 Neuropathology (14:00-17:30, Dec.10, 2016) Jing Zhang (章京), MD., PhD. Professor, Shaw Endowed Chair in Neuropathology, University of Washington, School of Medicine, Seattle, USA Topic: 2016 WHO classification of adult glioma Hsin-Yi Huang(黃馨儀), MD., PhD. Attending Physician, Department of Pathology, National Taiwan Univeristy Hospital, Taipei, Taiwan Topic: Updates on the diagnosis and molecular biology of pediatric high-grade gliomas Diego Shih-Chieh Lin (林士傑), MD. Attending Physician, Department of Pathology, Taipei Veteran General Hospital, Taipei, Taiwan Topic: Clinico-pathological study of Brain Metastases Ho Keung Ng (吳浩強), FRCPath, FRCPA, FCAP, FFPathRCPI, MIAC, FHKC Path. Associate Dean (Education), Faculty of Medicine, Chair Professor, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China Topic: How can one do molecular diagnostics of brain tumors in practice ? Tai-Tong Wong (黃棣棟), MD. Professor, Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan Topic: Treating of medulloblastoma integrating clinical factors and molecular diagnosis

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Dueng-Yuan Hueng(洪東源), MD., PhD. Superintendent, Triservice General Hospital, Penghu Branch, Penghu, Taiwan Topic: Omics data mining makes easy for the investigation of survival-correlated novel genes in human gliomas

S3 Novel Targets in Diseases (9:00—17:30, Dec.9, 2016) Program Convenor: Hsien-Jien Kung (龔行健), PhD. Distinguished Investigator and Academician, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan ✽Each section has 5 talks (15 minutes oral presentations and 3 minutes Q&A) 9:00-9:05 Opening 09:05-10:30 Targeting Cell signaling Moderators: Yi-Rong Chen (陳怡榮), PhD. Associate Investigator, Institute of Molecular and Genomic Medicine,National Health Research Institutes, Taiwan Ching-Liang Chu(朱清良), PhD. Associate Professor, Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taiwan Speakers: To be announced 10:30-11:00 Coffee break and poster viewing 11:00-12:30 Targeting Inflammation and Microbiota Moderators: Wen-Jye Lin (林文傑), PhD. Assistant Investigator, Immunology Research Center,National Health Research Institutes, Taiwan Hsin-Chih Lai (賴信志), PhD. Professor, Department of Medical Technology and Laboratory Science, College of Medicine, Chang Gung University, Taiwan Speakers: To be announced 12:30-14:00 Lunch and Poster viewing 14:00-15:30 Targeting Metabolism and mitochondria Moderators: Alan Yueh-Luen Lee (李岳倫), PhD. Associate Investigator, National Institute of Cancer Research, National Health Research Institutes, Taiwan Dar-Shong Lin (林達雄), MD., PhD. Associated Professor and Director, Mitochondrial Research Medicine, Department of Medical Research, Mackay Memorial Hospital, Mackay Medical College, Taiwan Speakers: To be announced 15

15:30-16:00 Coffee break and Poster viewing 16:00-17:30 Targeting Epigenetics Moderators: Yue-Liang Leon Guo (郭育良), MD.,PhD. Director and Distinguished Investigator, National Institute of Environmental health Science, National Health Research Institutes, Taiwan Li-Jung Juan (阮麗蓉), PhD. Investigator, Genomic Research Center, Academia Sinica, Taipei, Taiwan Speakers: To be announced 17:30-17:50

Awards ceremony

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