International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program SESSION A* – MONDAY, SEPTEMBER 2, 2:00 P.M. – 4:00 P.M. SESSION B* – TUESDAY, SEPTEMBER 3, 11:10 A.M. – 1:10 P.M. SESSION C* – WEDNESDAY, SEPTEMBER 3, 2:15 P.M. – 4:15 P.M. *Letter after your poster number denotes your scheduled session

___________________________________________________________________________________________________ 1A - APPLICATION OF WHOLE GENOME MAPPING FOR THE CHARACTERIZATION OF BACILLUS ANTHRACIS ISOLATES FROM CANADA

K. K. Amoako, Kristen Hahn, Matthew Thomas, Noriko Goji, Timothy Janzen; Canadian Food Inspection Agency, Lethbridge Laboratory, National Centres for Animal Disease, Lethbridge, Alberta, T1J 3Z4, Canada

2B - ASSESSMENT OF NEXT GENERATION SEQUENCING FOR THE IDENTIFICATION OF BACILLUS ANTHRACIS

K. S. Antonation, P. Mabon, C. R. Corbett; Bioforensics Assay Development and Diagnostics, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

3C - DETECTION OF BACILLUS ANTHRACIS DNA IN ENVIRONMENTAL SAMPLES BY NEXTGENERATION SEQUENCING 1

1

2

2

3

3

4

5

1

1

N. Be , J. Thissen , S. Gardner , K. McLoughlin , V. Fofanov , H. Koshinsky , S. Ellingson , T. Brettin , P.J. Jackson , C. Jaing ; 1 2 Physical and Life Sciences and Global Security Directorates, Lawrence Livermore National Laboratory, Livermore, CA, USA; 3 4 Eureka Genomics, Hercules, CA, USA; Department of Genome Science and Technology, University of Tennessee, Knoxville, TN, 5 USA; Oak Ridge National Laboratory, Oak Ridge, TN, USA

4A - PROTEOMIC ANALYSES AND WHOLE GENOME NEXT-GENERATION SEQUENCING OF THE NONPROTEOLYTIC BACILLUS ANTHRACIS V770-NPI-R (ATCC14185) STRAIN 1

1

1

1

Theodor Chitlaru , Inbar Gihon , Ofir Israeli , Anat Zvi , 1 2 1 1 1 2 Adi Beth-Din , Haim Levi , Ofer Cohen , Avigdor Shafferman ; Department of Biochemistry and Molecular Genetics; Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel

5B - HIGH-THROUGHPUT NGS TRANSCRIPTOMICS OF B. ANTHRACIS AND ITS HTRA MUTANT FOLLOWING PEROXIDE-INDUCED STRESS

Theodor Chitlaru, Ofer Cohen, Sharon Ehrlich, Inbar Gihon, Ofir Israeli, Anat Zvi, Adi Beth-Din and Avigdor Shafferman; Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel

6C - GENOME SEQUENCE OF A NOVEL BACILLUS STRAIN OF THE B. CEREUS GROUP ISOLATED FROM A THERMAL SPRING 1

2

3

3

4

5

2

2

2

J. V. A. Oliveira , T. Raiol , N. C. Farias , N. F. Almeida , G. P. Telles , J. C. Setubal , F A Torres , J Demarco , M. M. Brigido , 1 2 2 1 M. E. M. T. Walter , M. T. De-Souza , L M. P. Moraes ; Department of Computer Science, University of Brasilia, Brasilia, DF, 2 3 Brazil; Department of Cellular Biology, University of Brasilia, Brasilia, DF, Brazil; College of Computing, Federal University of 4 5 Mato Grosso do Sul, Campo Grande, MS, Brazil; Institute of Computing, Unicamp, Campinas, SP, Brazil; Department of Biochemistry, University of São Paulo, São Paulo, SP, Brazil

7A - DEVELOPMENT OF A WHOLE GENOME SNP-BASED GENOTYPING METHOD AND PUBLIC DATABASE FOR BACILLUS ANTHRACIS

A. Hoffmaster, C. Marston, M. Bell, S. Ranganathan, S. Changayil, R. Weil, D. MacCannell; Centers for Disease Control and Prevention, Atlanta, GA, USA

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

1

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 8B - SPORE LYSIS METHODS FOR INVESTIGATING PROTEOME DYNAMICS

David. S. Wunschel, Janine R. Hutchison, Casey L. Stamper, Brian H. Clowers, Marvin G. Warner; Pacific Northwest National Laboratory, Richland, WA, USA

9C - TRANSCRIPTOMICS AND PROTEOMICS ANALYSES OF BACILLUS THURINGIENSIS

J. P. Wang, J. He, Z. D. Liu, Z. N. Yu; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China

10A - HAL IS A BACILLUS ANTHRACIS HEME ACQUISITION PROTEIN M. Balderas, A. Maresso; Baylor College of Medicine, Houston, TX, USA

11B - GERMINATION AND LIFE CYCLE MONITORING OF STRAIN BACILLUS THURINGIENSIS GFP+CDO IN MICE

D. A. Cavalcante, J. C. de Orem, G. A. Hirata, K. W. R. Macedo, M. A. Merlone, M. T. De-Souza; Cell Department, University of Brasilia, Brasilia, DF, Brazil

12C - HOST-PATHOGEN INTERACTION: PROTEOMIC INSIGHTS INTO GROWTH REGULATION OF BACILLUS CEREUS 1

2

2

1

3

2 1

V. Doll , T. Grunert , E. Frenzel , S. Scherer , R. Vogelmann , M. Ehling-Schulz ; Microbial Ecology Group, WZW, Technische 2 Universität München, München, Germany; Functional Microbiology, Department of Pathobiology, University of Veterinary 3 Medicine Vienna, Vienna, Austria; Second Department of Internal Medicine, University Hospital Mannheim, Mannheim, Germany

13A - INHIBITION OF THE HUMAN INNATE IMMUNE RESPONSE TO BACILLUS ANTHRACIS PEPTIDOGLYCAN BY B. ANTHRACIS CAPSULE T. Jelacic, D. Chabot, S. Tobery, and A. Friedlander; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA

14B - CONTRIBUTION OF PURIFIED BACILLUS ANTHRACIS CAPSULE TO VIRULENCE IN MICE W. Ribot, D. Chabot, T. Obreiter, S. Tobery, A. Friedlander; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA

15C - RE-IMAGE-INING HEME UTILIZATION AS AN IRON-SOURCE DURING INFECTION FOR B. ANTHRACIS 1

2

2

2

2

1 1

C. Nobles , B. Zhu , H. Robinson , N. Wilganowski , E. Sevick , A. Maresso ; Baylor College of Medicine, Houston, TX, USA; 2 University of Texas Health Science Center, Houston, TX, USA

16A - HUMAN LUNG ANTIGEN-PRESENTING CELLS VARY IN PHAGOCYTIC POTENTIAL OF BACILLUS ANTHRACIS SPORES 1

2

2

1,2 1

V. Patel , J. Booth , E. Duggan , J. Metcalf ; Department of Microbiology and Immunology, University of Oklahoma Health 2 Sciences Center, Oklahoma City, OK, USA; Pulmonary and Critical Care Division, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

17B - STRUCTURE-FUNCTION CHARACTERIZATION OF CATALASES FROM BACILLUS ANTHRACIS 1

2

1

1

2

A. Rahi , M. Rehan , R. Garg , D. Tripathi , A.M. Lynn , 1 1 R. Bhatnagar ; Laboratory of Molecular Biology and Genetic Engineering, School of Biotechnology, Jawaharlal Nehru University, 2 New Delhi, India; School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India

18C - STABILITY OF VEGETATIVE BACILLUS ANTHRACIS IN RABBIT BLOOD

M. Valderas, K. Brooks, C. Johnson, S. Jones, F. Romero, L. Zinter, R. Sherwood; Lovelace Respiratory Research Institute, Albuquerque, NM, USA BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

2

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 19A - QUALIFICATION OF INHALATION ANTHRAX ANIMAL MODELS THROUGH THE FDA ANIMAL MODEL QUALIFICATION PROGRAM 1

2

2

1

2

1 1

T. Dreier , J. Hewitt , L. Lanning , J. Little , R. Slay , D. Yeskey ; Biomedical Advanced Research and Development Authority (BARDA), Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, 2 Washington DC, USA; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA

20B- A MURINE MODEL FOR GASTROINTESTINAL ANTHRAX INFECTION

T. Xie, C. Sun, K. Uslu, R. Auth, H. Fang, W. Ouyang, D. Frucht; Laboratory of Cell Biology, Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA

21C - COMPLEMENT MANIPULATION BY BACILLUS ANTHRACIS SPORES

C. Gu, S. Jenkins, Q. Xue, Y. Xu; Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX USA

22A - TOWARDS UNDERSTANDING GLOBAL CONTROL AND TIMING MECHANISMS OF CEREULIDE BIOSYNTHESIS IN BACILLUS CEREUS 1

2

1

3

4

2

1 1

E. Frenzel , R.T. Eijlander , T. Grunert , W. Gerner , M. Wagner , O.P. Kuipers , and M. Ehling-Schulz ; Functional Microbiology, 2 Dept. of Pathobiology, University of Veterinary Medicine Vienna, Austria; Molecular Genetics Group, Groningen Biomolecular 3 Sciences and Biotechnology Institute, University of Groningen, The Netherlands; Institute of Immunology, Dept. of 4 Pathobiology, University of Veterinary Medicine Vienna, Austria; Department of Microbial Ecology, Ecology Centre, University of Vienna, Austria

23B - PHYSIOLOGICAL FUNCTIONS OF TRANSCRIPTIONAL REPRESSOR CODY IN BACILLUS ANTHRACIS S. K. Kim, Y. G. Chai; Hanyang University ERICA Campus, Ansan, Republic of Korea

24C- ROLES OF TWO ATXA GENES IN CAPSULE AND TOXIN PRODUCTION OF BACILLUS CEREUS STRAIN G9241

J. Scarff, J. Vergis, F. Alem, C. Ventura, A. O’Brien; Uniformed Services University of the Health Sciences, Bethesda, MD, USA

25A - AN UP ELEMENT IN THE PROMOTER REGION OF BACILLUS CEREUS B-370 HEMOLYSIN II CHANGES THE TRANSCRIPTION INITIATION MECHANISM 1

Alexander S. Solonin1, Andrey M. Shadrin1,2, Zhanna I. Andreeva-Kovalevskaya1, Konstantin Severinov2,3,4; The Institute of 2 Biochemistry and Physiology of Microorganisms, Pushchino, Russia; Waksman Institute for Microbiology, Department of 3 4 Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ USA; Institute of Gene Biology; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

26B - MEDIA AND TEMPERATURE DEPENDENT VARIATIONS IN THE EXPRESSION OF BACILLUS ANTHRACIS SPORE COAT GENES A. Aronson; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA

27C - PHENOTYPIC EVALUATION OF BACILLUS ANTHRACIS SPORES PRODUCED UNDER DIFFERENT CULTURAL CONDITIONS

S. Hibbs, H. Bird, R. Thomas, T. Hawkyard; Defence Science Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, UK

28A -EXOSPORIUM ARCHITECTURE ALTERED THROUGH BCLA MUTATIONS OBSERVED BY ELECTRON CRYSTALLOGRAPHY S. Jiang1, D. Radford2, A. Moir1, P. Bullough1; 1Krebs Institute, Dept. of Molecular Biology and Biotechnology, University of 2

Sheffield, Sheffield, U.K.; Institute of Cell Biology, University of Edinburgh, King's Buildings, Edinburgh, UK

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

3

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 29B - BACILLUS ANTHRACIS, HUMAN PATHOGENIC BACILLUS CEREUS, AND GREAT APE PATHOGENIC BACILLUS CEREUS SECONDARY CELL WALL POLYSACCHARIDES DISPLAY BOTH CONSERVED AND UNIQUE STRUCTURAL FEATURES 1

2

2

3

2

2

1

1 1

L.S. Forsberg , N. Kamal , E. Saile , S.R. Klee , A.R. Hoffmaster , C.P. Quinn , R.W. Carlson , E.L. Kannenberg ; Complex 2 Carbohydrate Research Center, University of Georgia, Athens, GA, USA, Centers for Disease Control and Prevention, Atlanta, 3 GA, USA, Robert Koch-Institute, Berlin, Germany

30C - LOCALIZATION AND STRUCTURAL ANALYSIS OF A CONSERVED PYRUVYLATED EPITOPE IN THE SECONDARY CELL WALL POLYSACCHARIDE OF BACILLUS ANTHRACIS 1

2

2

3

1

1 1

L.S. Forsberg , T.G. Abshire , A. Friedlander , C.P. Quinn , E.L. Kannenberg , R.W. Carlson ; Complex Carbohydrate Research 2 Center, University of Georgia, Athens, GA, USA; United States Army Medical Research Institute of Infectious Diseases, Frederick, 3 MD, USA; Centers for Disease Control and Prevention, Atlanta, GA, USA.

31A - THE SECONDARY CELL WALL POLYSACCHARIDE OF BACILLUS ANTHRACIS PROVIDES THE SPECIFIC BINDING LIGAND FOR THE C-TERMINAL CELL WALL BINDING DOMAIN OF THE TWO PHAGE ENDOLYSINS, PLYL AND PLYG 1

2

3

3

1

1

3

4

3

J. Ganguly , L.Y. Low , N. Kamal , E. Saile , L.S. Forsberg , G. Gutierrez-Sanchez , A.R. Hoffmaster , R. Liddington , C.P. Quinn , 1 1 1 2 R.W. Carlson , E.L. Kannenberg ; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA; BShire HGT 3 4 Inc., Lexington, MA, USA; Centers for Disease Control and Prevention, Atlanta, GA, USA; Sanford-Burnham Medical Research Institute, La Jolla, CA, USA

32B - IDENTIFICATION OF AN INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE FAMILY PROTEIN AS A BXPB-DEPENDENT EXOSPORIUM PROTEIN OF BACILLUS ANTHRACIS K. Spreng and G. Stewart; Department of Veterinary Pathobiology and Bond Life Sciences Center, University of Missouri, Columbia, MO, USA

33C - CHARACTERIZATION OF UNPURIFIED AND MD76-R PURIFIED BACILLUS ANTHRACIS SPORES STORED IN STERILE WATER, PHOSPHATE BUFFERED SALINE, AND PHENOL

M. Valderas, K. Brooks, C. Johnson, S. Jones, F. Romero, L. Zinter, P. Kuehl, S. Storch, R. Sherwood; Lovelace Respiratory Research Institute, Albuquerque, NM, USA

34A - THE USE OF PERACETIC ACID AND SPORE GERMINANTS TO DECONTAMINATE BACILLUS ANTHRACIS SPORES CONTAMINATING ANIMAL BURIAL SITES IN TURKEY 1

2

2

2

3

1

2

1

Fatih Buyuk , Tom Pottage , Ant Crook , Suzanna Hawkey , Callum Cooper , Ozgur Celebi , Allan Bennett , Mitat Sahin , Les 3 1 2 3 Baillie ; Kafkas University, Kars, Turkey; Public Health England, Porton Down, UK; Cardiff University, Cardiff, Wales, UK

35B - DEVELOPMENT OF A REAL-TIME, MICROWAVE ENHANCED, RAPID DETECTION ASSAY FOR BACILLUS ANTHRACIS 1

2

2

1 1

L. T. Joshi , J. Lees , A. Porch , L.W.J. Baillie ; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK; 2 School of Engineering and Physical Sciences, Cardiff University, Cardiff, UK

36C - DECONTAMINATION OF MATERIALS CONTAMINATED WITH BACILLUS ANTHRACIS AND BACILLUS THURINGIENSIS AL HAKAM SPORES USING PES-SOLID, A SOLID SOURCE OF PERACETIC ACID

Tony L. Buhr, Claire M. Wells, Alice A. Young, Zachary A. Minter, Catherine A. Johnson, Amanda N. Payne, Derrell C. McPherson; Naval Surface Warfare Center, Dahlgren, VA, USA

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

4

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 37A - RESPONSE SURFACE MODELING FOR HOT, HUMID AIR DECONTAMINATION OF MATERIALS CONTAMINATED WITH BACILLUS ANTHRACIS ∆STERNE AND BACILLUS THURINGIENSIS AL HAKAM SPORES

Edward J. Prokop, John R. Crigler, Claire M. Wells, Alice A. Young, Tony L. Buhr; Naval Surface Warfare Center, Dahlgren, VA, USA

38B - WELSH NEMATODES ON ATTACK: BACILLUS ANTHRACIS DECONTAMINATION USING COMMON SOIL PREDATORS 2

1

2

2

2

2

1 1

B. Schelkle , Y. Choi , M. Wendling , W. Richter , J. Rogers , T. Huwar , L. Baillie ; Cardiff School of Pharmacy and 2 Pharmaceutical Sciences, Cardiff University, Cardiff, Wales, UK; Battelle, Columbus, OH, USA

39C - GROUND ANTHRAX BACILLUS REFINED ISOLATION (G.A.B.R.I.) METHOD FOR ANALYZING ENVIRONMENTAL SAMPLES WITH LOW LEVELS OF BACILLUS ANTHRACIS CONTAMINATION 1

1

2

3

5

1

Antonio Fasanella , Pietro Di Taranto , Giuliano Garofolo , Valeriana Colao , Antonio Balestrucci , Leonardo Marino , Rosanna 3 4 1 Adone , Martin Hugh Jones ; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, Anthrax Reference Institute of Italy, 2 3 Foggia, Italy, Istituto Zooprofilattico Sperimentale of Abruzzo and Molise “G. Caporale”, Teramo, Italy; Istituto Superiore di 4 Sanità, Rome, Italy; Department of Environmental Sciences School of the Coast & Environment, Louisiana State University, 5 Baton Rouge, LA, USA; University of Naples, Italy

40A - CONCENTRATION AND PURIFICATION OF BACILLUS ANTHRACIS STERNE SPORES USING IMMUNOMAGENTIC BEADS

Janine R. Hutchison, David S. Wunschel, Casey L. Stamper, Eric M. Winder, Kai-For Mo, Marvin G. Warner; Pacific Northwest National Laboratory, Richland, WA, USA

41B - DIFFERENTIAL DETECTION OF BACILLUS ANTHRACIS SPORES AND VEGETATIVE CELLS USING MULTIPLE ANTIBODY PANELS 1

1

1

1

2

1

Neeraja Venkateswaran , Jennifer Walker , Thomas O’Brien , William Nelson , Kodumudi Venkateswaran , Beverly Mangold ; 1 2 Tetracore, Rockville, MD, USA; Omni Array Biotechnology, Rockville, MD, USA

42C - BACILLUS ANTHRACIS DOES NOT REPLICATE AND SURVIVE IN THE BLOWFLY CALLIPHORA VICINA 1

2

1 1

B. von Terzi , P.C.B. Turnbull and W. Beyer ; University of Hohenheim, Institute of Environmental and Animal Hygiene, 2 Stuttgart, Germany; Salisbury, UK

43A - IDENTIFICATION OF GENES REQUIRED FOR SOIL SURVIVAL IN BACILLUS THURINGIENSIS BY TRANSPOSON-DIRECTED INSERTION SITE SEQUENCING

A. Bishop, P. Rachwal, A. Vaid; Defence Science and Technology Laboratory, Detection Department, Porton Down, Salisbury, Wiltshire, UK

44B - PORCINE ANTHRACOID CASES ANALYSIS

O. Koltchik, B. Stegniy, A. Gerilovych, A. Buzun; National Scientific Centre, Institute for Experimental and Clinical Veterinary Medicine, Kharkiv, Ukraine

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

5

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 45C - GENETIC DIVERSITY OF CRYSTALLINE PROTEIN ENCODING GENES IN NATIVE BACILLUS THURINGIENSIS STRAINS ISOLATED FROM DIVERSE EXTREME ENVIRONMENTS OF INDIA 1

2

3

4

5

6

1 1

S.A. Lone , S.Kumar , A. Gupta , G.T. Gujar , A.K. Saxena , A. Malik , J.C. Padaria* ; Biotechnology and Climate Change, 2 National Research Centre on Plant Biotechnology (NRCPB), Pusa Campus, New Delhi, India; National Bureau of Agriculturally 3 Important Microorganisms (NBAIM), Mau, Utter U.P, India; Central Plantation Crops Research Institute (CPCRI), Kasargod, 4 5 Kerala, India; Division of Entomology, Indian Agriculture Research Institute (IARI), New Delhi, India; Division of Microbiology, 6 Indian Agriculture Research Institute (IARI), New Delhi, India; Department of Microbiology, Faculty of Agriculture, Aligarh Muslim University (AMU), Aligarh, India

46A - ON THE FATE OF BACILLUS CEREUS SENSU LATO IN MULTI-SPECIES COMMUNITIES: BIOFILM FORMATION AND PLASMID TRANSFER P. Modrie, O. Henriet, T. Vanzieleghem, J. Mahillon; Université catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium

47B - SEQUENCE-BASED POPULATION STRUCTURE OF BACILLUS ANTHRACIS C. Olsen, K. Qaadri,; Biomatters, Inc. 185 Clara Street Suite 101A San Francisco, CA USA

48C - MOLECULAR BEACONS FOR THE DETECTION AND DESTRUCTION OF BACTERIAL CELLS AND SPORES

D. Rice, H. Gan, A. Plaunt, B. Smith; Department of Chemistry and Biochemistry and the Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN, USA

49A - INFORMING ZOONOSIS SURVEILLANCE WITH ANIMAL MOVEMENT ECOLOGY: TRACKING ELK DURING THE MONTANA ANTHRAX RISK PERIOD 1,2

1

1,2

3 1

Jason K. Blackburn , Lillian R. Morris , Karoun Bagamian , Valpa Asher ; Spatial Epidemiology & Ecology Research 2 Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA; Emerging Pathogens Institute, University of 3 Florida, Gainesville, FL, USA; Turner Enterprises, Inc., Bozeman, MT, USA

50B - ANTHRAX RETROSPECTIVE EPIZOOTIC ANALYSIS IN UKRAINE

O. Nevolko, L. Maruschak; State Research Institute of Laboratory Diagnostic and Veterinary Sanitary Expertise, Kyiv, Ukraine

51C - A SURVEY OF LABORATORY SAMPLING AND TESTING FOR THE DIAGNOSIS OF ANTHRAX IN ANIMALS IN GEORGIA 2009-2012

M. Nikolaishvili, M Zakareishvili, I. Beradze, M. Donduashvili, M. Kokhreidze, N. Vepkhvadze, L Gelashvili; Laboratory of the Ministry of Agriculture (LMA), Tbilisi, Georgia

52A - BIOSAFETY IN ANTHRAX BACTERIOLOGICAL RESEARCH

Irma Beradze, M. Nikolaishvili, M. Zakareishvili; Laboratory of Ministry of Agriculture (LMA), Tbilisi, Georgia

53B - BLOWFLIES IN THE TAÏ NATIONAL PARK CONTAIN LIVING BACILLUS CEREUS BIOVAR ANTHRACIS BACTERIA: A POTENTIAL SOURCE FOR DISSEMINATION 1

2

2

1,2

S. Dupke , M. Stockhausen , C. Hoffmann , F. Zimmermann , 1 1 1 2 1 2 S.R. Klee , T. Franz , R. Grunow , F. Leendertz ; Centre for Biological Threats and Special Pathogens (ZBS 2); Epidemiology of Highly Pathogenic Microorganisms (P 23), Robert Koch-Institut, Berlin, Germany

54C - DIVERSITY OF AUSTRALIAN BACILLUS ANTHRACIS STRAINS MEASURED BY MULTIPLE LOCUS VNTR ANALYSIS AND WHOLE GENOME SEQUENCE TYPING 1

1

1

1

2

M. Fegan , J. Muller , I. Mohammad , S. Warner , R. Paskin , 1 1 R. Mann ; Department of Environment and Primary Industries, Bioscience Research Division, Centre for AgriBiosciences, 2 Victoria, Australia. Chief Veterinary Officers Unit, Department of Environment and Primary Industries, Victoria, Australia

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

6

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 55A - CHARACTERIZATION OF BACILLUS ANTHRACIS USING MULTIPLE LOCUS VARIABLE NUMBER TANDEM REPEAT ANALYSES (MLVA) FOR THE TYPICAL AFRICAN LABORATORY 2,3

1

4

2,3,5

1 1

Ayesha Hassim , Yolande Hauck , Jenny Rossouw , Gilles Vergnaud , Henriette van Heerden ; University of Pretoria, Faculty 2 of Veterinary Science, Department of Veterinary Science, Pretoria, South Africa; Univ Paris-Sud, Institut de Génétique et 3 4 Microbiologie, Orsay, France; CNRS, Orsay, France; National Institute for Communicable Diseases, Special Bacterial Pathogens 5 Unit, Johannesburg, South Africa; 5-DGA/MRIS-Mission pour la Recherche et l'Innovation Scientifique, Bagneux, France

56B - REAL-TIME PCR DETECTION AND SNP GENOTYPING OF BACILLUS ANTHRACIS STRAINS ISOLATED DURING HUMAN ANTHRAX OUTBREAKS THAT OCCURRED IN 2012 IN THE COUNTRY OF GEORGIA 1

1

1

1

1

1

1

2

1

E.Khmaladze , G. Chanturia , E.Zhgenti , N. Abazashvili , M. Zakalashvili , M. Kekelidze , L.Malania , M. Nikolich , S. Tsanava , 1 1 1 2 N. Tsertsvadze , P. Imnadze ; National Center for Disease Control and Public Health, Tbilisi, Georgia; Walter Reed Army Institute of Research, Silver Spring, MD, USA

57C - CHARACTERIZATION OF A BACILLUS CEREUS ISOLATE HARBORING BACILLUS ANTHRACIS TOXIN GENES ASSOCIATED WITH AN ANTHRAX-LIKE CUTANEOUS LESION 2

1

3

3

3

3

1

1

1

1

1

C. Marston , H. Ibrahim , P. Lee , G. Churchwell , M. Gumke , D. Stanek , A. Boyer , M. Candela , J. Barr , H. Li , D. Boulay , L. 1 1 1 1 2 Cronin , J. Gee , A. Hoffmaster ; Centers for Disease Control and Prevention, Atlanta, GA, USA; Villages Regional Hospital, Lady 3 Lake, FL, USA; Florida Department of Health, Jacksonville, FL, USA

58A - ANTHRAX ASSIST: A DYNAMIC MODELING TOOL FOR PUBLIC HEALTH DECISION SUPPORT DURING AN ANTHRAX EVENT 1

2

2

2

2 1

N. Hupert , G. Rainisch , S. Shadomy , W. Bower , M. I. Meltzer ; Weill Medical College, Cornell University, New York, NY, USA; 2 Centers for Disease Control and Prevention, Atlanta, GA, USA

59B- SURVEILLANCE OF ANTHRAX FOCI IN GEORGIA DURING 2003-2012

Nikoloz Tsertsvadze*, Lile Malania*, Marine Ramishvili, Natalia Abazashvili, Julietta Manvelyan, Mariam Broladze, Ekaterine Khmaladze, Mariam Zakalashvili, Paata Imnadze; National Center for Disease Control and Public Health of Georgia, Tbilisi, Georgia

60C- HUMAN HEALTH RISK ASSESSMENT OF BACILLUS CEREUS ATCC 14579 1

1

2

3

3

1 1

M. Breton , V. Albert , A. Tayabali , D. Bulinski , S. ElOuakfaoui , D. Ashby ; New Substances Assessment & Control Bureau, 2 Safe Environment Directorate, Health Canada, Ottawa, Ontario, Canada; Environmental Health Science and Research Bureau, 3 Environmental and Radiation Health Science Directorate, Health Canada, Ottawa, Ontario, Canada; Emerging Priorities Division, Science and Risk Assessment Directorate, Environment Canada, Gatineau, Québec, Canada

61A- INTERNATIONAL INTERNET-BASED GENOTYPE DATABASES FOR BACILLUS ANTHRACIS 1

2

1

2

1,3

2

C. Tourterel , S. Thierry , P. Le Flèche , N. Madani , S. Derzelle , G. Vergnaud ; 1University Paris Sud, Orsay, France; 2 University Paris Est, Anses, Maisons-Alfort, France; 3DGA/MRIS, Bagneux, France

62B - ANTHRAX OUTBREAKS AND B. ANTHRACIS ISOLATION IN VIETNAM, ISSUES OF PUBLIC HEALTH 1

2

2

1

Ha Thi Thu Hoang , Akiko Okutani , Ionue Satoshi , Hai Thanh Pham Anh Duc Dang1, Tram Thuy Nguyen1, Hung Ngoc Dang3, Hien Tran Nguyen1; 1National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; 2National Institute of Infectious Disease, Tokyo, Japan; 3Dien Bien Preventive Medicine Center, Vietnam

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

7

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 63C - ANTHRAX IN A BACKYARD DOMESTIC DOG IN UKRAINE: A CASE REPORT 1

3

2

4

5

5 1

Atrem Skrypnyk , Valeriy Skrypnyk , Mikeljon Nikolich , Jason Farlow , Karoun H. Bagamian , Jason K. Blackburn ; Black & 2 Veatch Special Projects Corp., Kyiv, Ukraine; State Scientific Control Institute of Biotechnology and Strains of Microorganisms, 3 4 Kyiv, Ukraine; Walter Reed Army Institute of Research, Silver Spring, MD, USA; Arizona State University, Tempe, AZ, USA; 5 Spatial Epidemiology & Ecology Research Laboratory, Emerging Pathogens Institute & Department of Geography, University of Florida, Gainesville, FL, USA

64A- HEROIN-ASSOCIATED INJECTIONAL ANTHRAX IN EUROPE: LESSONS FROM THE FRENCH CASE

F. Thibault1*, F. Biot1, G. Larigauderie2, M. Levast3, S. Forcet1, R. Gebeile3, S. Plumet2, E. Valade1, O. Rogeaux3; 1French National Reference Centre for anthrax. Military biomedical research institute, Lyon FRANCE; 2DGA-Maîtrise NRBC, Vert-le-Petit, FRANCE; 3Chambéry Hospital, Chambéry, FRANCE

65B- ANTHRAX LETHAL FACTOR PURIFICATION AND DETECTION OF ACTIVITY USING AN INTRAMOLECULARLY QUENCHED FLUORESCENT SUBSTRATE C. Beesley, M. McDonald, C. Marston, M. Gallegos, A. Boyer, A. Hoffmaster; Centers for Disease Control and Prevention, Atlanta, GA, USA

66C - DOMINANT NEGATIVE PHENOTYPE OF BACILLUS THURINGIENSIS CRY1AB, CRY11AA AND CRY4BA MUTANTS SUGGEST HETERO-OLIGOMER FORMATION AMONG DIFFERENT CRY TOXINS 1

1

1

1

1

2

2

1

1 1

D. Carmona , C. Rodríguez , C. Muñoz , L. Portugal , C. Pérez , R. de Maagd , P. Bakker , M. Soberón , A. Bravo ; Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, 2 México; Bioscience, Plant Research International, Wageningen, The Netherlands

67A- DEVELOPMENT AND VALIDATION OF PROTECTIVE ANTIGEN ASSAYS FROM BACILLUS ANTHRACIS 1

1

2

3

1 1

2

E. O’Connor , S. E. Carpenter , B. Simpson , M. Kelly , L.S. Casey ; Elusys Therapeutics, Inc., Pine Brook, NJ, USA; Advion, Ithaca, 3 NY, USA; MKelley Consulting LLC, West Chester, PA, USA

68B- NEXT GENERATION DISCOVERY OF BACILLUS THURENGIENSIS DELTA-ENDOTOXINS E. Dunn, R. Thayer, K. Roberts, D. Lehtinen, T. Eberle, K. Sampson; Bayer CropScience, Morrisville, NC, USA

69C - ULTRA-SENSITIVE MULTIPLEXED DETECTION OF ANTHRAX LETHAL FACTOR AND EDEMA FACTOR BY MASS SPECTROMETRY 1

2

1

2

1

1

1 1

M. Gallegos-Candela , R. Lins , K. Isbell , J. Heitz , A.R. Woolfitt , J.R. Barr , A.E. Boyer ; Centers for Disease Control and 2 Prevention, Atlanta, GA, USA; Battelle - Technical On-Site Professional Services, Atlanta, GA, USA

70A- CHARACTERIZATION OF SOME UNUSUAL BACIILUS CEREUS HARBOURING PXO2RELATED VIRULENCE GENES ISOLATED FROM A TRADITIONAL FERMENTED WEST AFRICAN FOOD CONDIMENT 1

2

3

1

1

Christine Kando , Line Thorsen , Niels Bohse Hendriksen , Hagrétou Sawadogo , Bréhima Diawara , Georges Anicet 4 2 1 Ouédraogo , Lene Jespersen ; Food Technology Department (DTA / IRSAT / CNRST), Ouagadougou 03 BP 7047, Burkina Faso; 2 3 Department of Food Science, Faculty of Life Sciences, University of Copenhagen, Denmark; Department of Environmental 4 Science, Aarhus University, Denmark; Université Polytechnique de Bobo-Dioulasso, 01 BP 1091 Bobo-Dioulasso, Burkina Faso

71B- TOWARDS UNDERSTANDING THE MODE OF ACTION OF BACILLUS CEREUS ENTEROTOXIN COMPLEX NHE

A. Didier, N. Jessberger, U. Heilkenbrinker, R. Dietrich, K. Zhu, E. Märtlbauer; Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig - Maximilians-Universität München, Schönleutnerstr. 8, 85764 Oberschleißheim, Germany

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

8

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 72C- ANTHRAX EDEMA FACTOR TOXICITY IS STRONGLY MEDIATED BY THE N-END RULE C. Leysath, D. Phillips, D. Crown, R. Fattah, M. Moayeri, S. Leppla; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

73A - ENHANCEMENT OF INSECTICIDAL ACTIVITY OF DOMAIN III Β16 MUTANTS AGAINST SPODOPTERA FRUGIPERDA (LEPIDOPTERA: NOCTUIDAE) 1

2

1

1

1 1

I. Gómez , J. Ocelotl , G. Peña , A. Bravo , M. Soberón ; Instituto de Biotecnología, Universidad Nacional Autónoma de México, 2 Cuernavaca, Morelos, México; Centro de Investigaciones en Biotecnología, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México

74B- DEVELOPMENT AND CHARACTERISATION OF MONOCLONAL ANTIBODIES AGAINST THE NHEC COMPONENT OF THE BACILLUS CEREUS NON-HEMOLYTIC ENTEROTOXIN

R. Dietrich, K. Schauer, U. Heilkenbrinker, A. Didier, K. Zhu, E. Märtlbauer; Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, Oberschleißheim, Germany

75C - MONOCLONAL ANTIBODIES CAPABLE OF DETECTING ANTHRAX TOXIN COMPLEXES R. Stoddard, C. Quinn, J. Schiffer, S. Soroka, L. Dauphin, A. Hoffmaster; Centers for Disease Control and Prevention, Atlanta, GA, USA

76A- OCCURRENCE OF BACILLUS CEREUS SENSO LATO IN WHOLE MILK IN RIO DE JANEIRO - BRAZIL: TOXIGENIC CHARACTERIZATION AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF THE STRAINS

J. Q. Chaves, E. P. de Paiva, C. F. G. Cavados, L. Rabinovitch, A. M. Vivoni; Instituto Oswaldo Cruz – Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

77B- HIGH SENSITIVITY ASSAY TO QUANTIFY ANTHRAX TOXINS IN A CLINICAL MATRIX 1,2

1,2

1,2

2 1

N. Kamal , M. Epperson , P. Maniatis , and C. P. Quinn ; Atlanta Research and Education Foundation, Decatur GA, USA; 2 Centers for Disease Control and Prevention, Atlanta GA, USA

78C - QUANTIFICATION OF ANTHRAX TOXINS USING MULTI-TARGET, MULTI-ANTIBODY DETECTION 1,2

1,2

2 1

1,2

N. Kamal , M. Epperson , P. Maniatis , C. P. Quinn ; Atlanta Research and Education Foundation, Decatur GA, USA; 2

Centers for Disease Control and Prevention, Atlanta GA, USA

79A- RECOMBINANT ACELLULAR VACCINES TESTED IN GOATS FOR IMMUNOGENICITY AND PROTECTIVITY 1

2

2

3

4

4

1 1

S.M. Köhler , M. Sahin , S. Otlu , M. Doganay , O. Ndumnego , H. van Heerden , W. Beyer ; University of Hohenheim, 2 3 Stuttgart, Germany; Kafkas University, Faculty of Veterinary Medicine, Dept. of Microbiology, 3640 Kars, Turkey; Erciyes 4 University, Faculty of Medicine, Department of Infectious Diseases, 38039 Kayseri, Turkey; University of Pretoria, Department of Veterinary Tropical Diseases, Onderstepoort, South Africa

80B- IMMUNOGENICITY AND SAFETY STUDY OF A THREE-DOSE BIOTHRAX REGIMEN FOR POST-EXPOSURE PROPHYLAXIS OF ANTHRAX IN HEALTHY ADULTS 1

1

1

1

R. Hopkins , C. Howard , E. Hunter-Stitt , M. Tomson , 1 1 1 1 1 2 3 4 5 6 P. Kaptur , S. Sari , V. Montalvo-Lugo , E. Vert-Wong , B. Pleune , T. Rudge , D. Muse , E. Sheldon , M. Davis , C. Strout ; 1 2 3 Emergent BioSolutions, Gaithersburg, MD, USA; Battelle Biomedical Research Center, West Jefferson, OH, USA, Jean Brown 4 5 Research, Salt Lake City, UT, USA, Miami Research Associates, South Miami, FL, USA, Rochester Clinical Research Inc., 6 Rochester, NY, USA, Coastal Carolina Research Center, Mount Pleasant, SC, USA

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

9

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 81C- CHARACTERISATION OF THE HUMAN ANTIBODY RESPONSE TO THE UK ANTHRAX VACCINE 1,2

3

1

4

5

1 1

Ezra Linley , Hannah Cuthbertson , Callum Cooper , Hugh Dyson , Rebecca Ingram , Les Baillie ; School of Pharmacy and 2 3 Pharmaceutical Sciences, Cardiff University, Wales, UK; University College London, England, UK; Public Health England, Porton 4 5 Down, UK; Dstl, Porton Down, UK; Centre for Infection and Immunity, Queen’s University Belfast, Belfast, UK

82A -EVALUATION OF THE POST-EXPOSURE PROPHYLACTIC EFFICACY OF ORALLY ADMINISTERED AZITHROMYCIN AND CLARITHROMYCIN AGAINST INHALATION ANTHRAX IN CYNOMOLGUS MACAQUES 1

1

1

1

1

1

1

2

1

J. Boydston , J. Rayner , J Trombley J. Bohannon , D. Papac , J. Mann , B. Yamamoto , N. Richardson-Harman , R. Watkins ; 1 2 Southern Research, Birmingham, AL, USA; Alpha Stat Consult LLC, Damascus, MD, USA

83B- SELECTING IMMUNE CORRELATES OF PROTECTION FOR ANTHRAX BY LASSO IN BAYESIAN BINARY REGRESSION 2

1

1

3

2 1

L. Chen , J. Schiffer , S. Dalton , D. Madigan , C.P. Quinn ; Atlanta Research and Education Foundation, Atlanta, GA, USA; 3 Centers for Disease Control and Prevention, Atlanta, GA, USA; Columbia University, New York, NY, USA

2

84C- LOGISTIC REGRESSION MODELS BRIDGING NON-HUMAN PRIMATE CORRELATES OF PROTECTION TO REASSESS THE HUMAN AVA BOOSTER SCHEDULE 1

2

2

3

3

1 1

J. Schiffer , S. Dalton , L. Chen , N. Niemuth , C. Sabourin , C.P. Quinn ; Centers for Disease Control and Prevention, Atlanta, GA, 2 3 USA; Atlanta Research and Education Foundation, Atlanta, GA, USA; Battelle, Columbus, OH, USA

85A - ENGINEERING UNNATURAL VARIANTS OF PLANTAZOLICIN THROUGH CODON REPROGRAMMING C. Deane, D. Mitchell; University of Illinois, Urbana, IL, USA

86B- INULIN AND MURABUTIDE ARE EFFECTIVE ADJUVANTS FOR RPA-BASED ANTHRAX VACCINATION 2

1

1

1* 1

Brandon Feinen , Nikolai Petrovsky , Anita Verma , and Tod J. Merkel ; Division of Bacterial, Parasitic and Allergenic Products, 2 Center for Biologics Evaluation and Review, FDA, Bethesda, MD, USA; Flinders Medical Centre and Vaxine Pty Ltd, Bedford Park, South Australia

87C - LOCALIZED AND SYSTEMIC ADVERSE EVENTS AFTER ANTHRAX VACCINATION ARE ASSOCIATED WITH DISTINCT SEROLOGICAL MEASURES 1,2

1,2

3

3

3

1,2,4 1

L. Garman , D. Farris , C. Spooner , M. Nelson , R. Engler , J. James ; Oklahoma Medical Research Foundation, 2 Department of Arthritis and Clinical Immunology, Oklahoma City, OK, USA; Oklahoma University Health Science Center, 3 Department of Microbiology and Immunology, Oklahoma City, OK, USA; Walter Reed National Military Medical Center, 4 Bethesda, MD, USA; Oklahoma University Health Science Center, Departments of Medicine and Pathology, Oklahoma City, OK, USA

88A - A BIODEGRADABLE NANOPARTICULATE ADJUVANT FOR SUBUNIT ANTHRAX VACCINE: SYNTHESIS, FORMULATION AND PRECLINICAL STUDY 1

2

2

2

1

2 1

Y. Gauthier , C. Primard , C. Terrat , A. Borel , JN Tournier , B. Verrier ; Institut de Recherche Biomédicale des Armées, Unité 2 Interactions Hôte-pathogène, La Tronche, France; CNRS-Institut de Biologie et Chimie des Protéines, Lyon, France

89B- COMPARATIVE ANALYSIS OF FRESHLY PREPARED AND STORED RECOMBINANT PROTECTIVE ANTIGEN (RPA) VACCINE FORMULATIONS

Anita Verma, Leslie Wagner, Drusilla L. Burns; Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

10

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 90C- IMMUNOGENICITY AND PROTECTIVE EFFICACY OF THE STERNE 34F2 LIVE SPORE ANTHRAX VACCINE IN GOATS 1

2

1

2

1 1

O. Ndumnego , S. Koehler , J. Crafford , W. Beyer , H. van Heerden ; Department of Veterinary Tropical Diseases, University of 2 Pretoria, Onderstepoort, South Africa; Institute of Environmental and Animal Hygiene, University of Hohenheim, Stuttgart, Germany

91A-FERRIC-CAPSULE POLYMERS FROM BACILLUS ANTHRACIS PROTECT AGAINST ANTHRAX TOXIN LETHALITY 1

2

1

1

2

3

Alexander F. Kintzer , Jakob von Moltke , Allyson K. Sia , Catherine A. Cassou , Michael J. Brown , Naomi Latorraca , Nancy K. 4 4 1,5 1 2 1,2,3,5 1 Montgomery , Paul J. Jackson , Evan R. Williams , Kenneth N. Raymond , Russell E. Vance , Bryan A. Krantz ; Department of 2 Chemistry, University of California, Berkeley, CA, USA; Department of Molecular & Cell Biology, University of California, Berkeley, CA, USA; 3Amgen Scholars Program, University of California, Berkeley, CA, USA; 4Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA; 5California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA

92B- EARLY INNATE, HUMORAL AND CELL-MEDIATED RESPONSES OF AVA.201 PHASE 1B SUBJECTS RECEIVING BIOTHRAX AND CPG 7909 1§

1§

2

1

1

1

1

1

1 1

J. Minang , J. Inglefield , E. Bernton , A. Harris , J. Lathey , D. Alleva , D. Sweeney , R. Hopkins , M. Lacy ; Emergent 2 § BioSolutions, Gaithersburg, MD USA; Present affiliation: Pathway Pharmacology LLC, Chevy Chase, MD, USA; these authors contributed equally

93C- U.S. FOOD AND DRUG ADMINISTRATION’S MEDICAL COUNTERMEASURES INITIATIVE – STRENGTHENING REGULATORY SCIENCE TO SUPPORT DEVELOPMENT AND APPROVAL OF MEDICAL COUNTERMEASURES FOR BACILLUS ANTHRACIS

T. MacGill, R. Raghuwanshi, K. Armstrong, P. Chamberlain, E. Jones, J. Hu-Primmer; Office of Counterterrorism and Emerging Threats, Office of the Chief Scientist, Office of the Commissioner, US FDA, Silver Spring, MD, USA

94A- EVALUATION OF ENCAPSULATED PROTECTIVE ANTIGEN DOMAIN 4 PLGA NANOPARTICLES AS A SINGLE-DOSE VACCINE CANDIDATE AGAINST ANTHRAX 1

1

1

2

1 1

Manish Manish , Amit Rahi , Manpreet Kaur , Samer Singh , Rakesh Bhatnagar ; Laboratory of Molecular Biology and Genetic 2 Engineering, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India; Special Centre for Nano Sciences, Jawaharlal Nehru University, New Delhi, India

95B- QUANTITATIVE ANTI-ANTHRAX IGG ELISA CORRELATES WITH THE ANTHRAX TOXIN NEUTRALIZATION ASSAY IN GOATS 1

1

2

1 1

O. Ndumnego , J. Crafford , W. Beyer , H. van Heerden ; Department of Veterinary Tropical Diseases, University of Pretoria, 2 Onderstepoort, South Africa; Institute of Environmental and Animal Hygiene, University of Hohenheim, Stuttgart, Germany

96C- VACCINE PROTECTION AGAINST BACILLUS CEREUS-MEDIATED RESPIRATORY ANTHRAX-LIKE DISEASE IN MICE 1,2

1,2

1,2

1,2

1,2

3

1,2

So-Young Oh , Hannah Maier , Jay Schroeder , Derek Elli , G. Stefan Richter , James M. Musser , Lauriane E. Quenee , 1,2 1,2 1 Dominique M. Missiakas , Olaf Schneewind ; Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Argonne, IL, 2 3 USA; Department of Microbiology, University of Chicago, Chicago, IL, USA; Department of Pathology and Genomic Medicine, The Methodist Hospital System, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX, USA

97A- THERAPEUTIC EFFICACY OF ANTHRAX IMMUNE GLOBULIN INTRAVENOUS (AIGIV) IN A RABBIT MODEL OF INHALATION ANTHRAX 1

2

3

3

R. Patnaikuni , S. Kammanadiminti , J. Comer , G. Meister , 1 1 1 1 2 C. Sinclair , L. Saward , S. Kodihalli ; Cangene Corporation, Winnipeg, MB, Canada; was an employee of Cangene Corporation, 3 Winnipeg, MB, Canada at the time of study; Battelle Biomedical Research Center, West Jefferson, OH, USA BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

11

International Bacillus ACT Conference September 1-5, 2013 Victoria, BC Canada

Scientific Poster Program 98B- ANTIBODY RESPONSES TO PROTECTIVE ANTIGEN SYNTHETIC PEPTIDES AS IMMUNE CORRELATES OF PROTECTION AGAINST ANTHRAX

V. Semenova, S. Dalton, P. Svoboda, J. Pohl, S. Soroka, J. Schiffer, C. P. Quinn; Centers for Disease Control and Prevention, Atlanta, GA, USA

99C- DETECTION OF ENDOGENOUS ANTI-PA ANTIBODIES IN ANTHRAX-INFECTED RABBITS AFTER TREATMENT WITH ETI-204 1

1

1

2

2

1

1 1

A. Shadiack , E. O’Connor , S. Carpenter , J. Mondick , J. French , H. Tang , and L. Casey ; Elusys Therapeutics Inc., Pine Brook, 2 NJ, USA; Metrum Research Group, Tariffville, CT, USA

100A- PHARMACOKINETICS OF ETI-204, AN ANTI-PA MONOCLONAL ANTIBODY, IN HEALTHY AND ANTHRAX-INFECTED RABBITS AND MONKEYS FOLLOWING IV AND IM ADMINISTRATION 1

2

1

1

1

1 1

H. Tang , J. Mondick , E. O’Connor , S. Carpenter , L. Casey , A. Shadiack ; Elusys Therapeutics Inc., Pine Brook, NJ, USA; 2 Metrum Research Group, Tariffville, CT, USA

101B- RABBIT MODEL OF ANTHRAX FOR EXPLORING COMPLEMENTARITY OF ANTITOXIN/ANTIBIOTIC COMBINATION THERAPY ON SURVIVAL AND DEVELOPMENT OF ADAPTIVE IMMUNITY 1

1

1

1

1 1

N. Serbina , A. Shadiack , E. O’Connor , S. Carpenter , L. Casey ; Elusys Therapeutics Inc., Pine Brook, NJ, USA

102C- EFFECT OF ANTHRAX IMMUNE GLOBULIN ON IMMUNE RESPONSE TO BIOTHRAX® AND SERUM LEVOFLOXACIN LEVELS IN NEW ZEALAND WHITE RABBITS 1

1

2

2

1

1

1

1

N.V. Malkevich , S. Basu , T.L. Rudge , Jr., K.H. Clement , A.C. Chakrabarti , R.T. Aimes , G.S. Nabors , M.H. Skiadopoulos , 1 1 2 B. Ionin ; Emergent BioSolutions, Gaithersburg, MD, USA; Battelle Biomedical Research Center (BBRC), West Jefferson, OH, USA

103A- SMALL MOLECULE INHIBITORS OF LETHAL FACTOR PROTEASE ACTIVITY PROTECT AGAINST ANTHRAX INFECTION 1

1

2

2

2

1

1 1

M. Moayeri , D. Crown , G. Jiao , S. Kim , A. Johnson , C. Leysath , S. H. Leppla ; Laboratory of Parasitic Diseases, National 2 Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; PanTheraBiopharma, LLC, Aiea, HI, USA

104B- INTRANASAL DELIVERY OF A BIOLOGIC NANOPARTICLE VACCINE INDUCES ROBUST LOCAL AND SYSTEMIC IMMUNE RESPONSES TO MULTIPLE BACILLUS ANTHRACIS ANTIGENS 1

1

2

1

1

1

1

1

2

1

A. Dunkle , C. Blanchette , T. Boone , M. Corzett , C. Lychak , M. Hwang , N. Fischer , Paul Hoeprich , Adam Driks , Amy Rasley ; 1 2 Lawrence Livermore National Laboratory, Livermore, CA, USA; Loyola University Medical Center, Maywood, IL, USA

105C - NOVEL GENOTYPING BY SNPS SELECTED FROM GENOME-WIDE ANALYSIS OF B. ANTHRACIS ISOLATED IN JAPAN AND MONGOLIA 1

2

2

3

4

4

1 1

A. Okutani , K. Tungalag , D. Tserennorov , B. Bazartseren , H. Thi Thu Ha , T.N. Hien , S. Inoue ; Department of Veterinary 2 3 Science, National Institute of Infectious Diseases, Japan; National Center for Zoonotic Disease; Institute of Veterinary 4 Medicine, Ulaanbaatar, Mongolia; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

BACT 2013 Scientific Poster Program Agenda Date: August 27, 2013

12