Scientific Group on Methodologies for the Safety Evaluation of Chemicals *Philippe Bourdeau,

Director of Environmental Research, Commission of the European Communities, Rue de la Loi 200, B-1049, Brussels, Belgium

N.P. Bockov,

Director, Institute of Medical Genetics, Kasirskoe sosse 6A, Moscow 115478, USSR

*Gordon C. Butler,

Director, Division of Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Canada KIA OR6

*J .R. Hickman,

Director General, Environmental Health Directorate, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada KIA OL2 SWAT/, 27, Dr. Radhakrishnan Salai, Mylapore, Madras 600 004, India Czechoslovak Academy of Sciences, Institute of Entomology, Vinicna 7, Prague 2, Czechoslovakia Professor and Chairman, Departments ofCommunity, Environmental and Occupational Medicine, Ein Shams University, PO Box 38, Abbassia, Cairo, Egypt Institute for Environmental Medicine, New York University Medical Center, 550 First Avenue, New York, New York, USA 10016 (Chairman) Environmental Advisory of the Minister of Health, Lopez Cotilla 739, Col del. Valle 03100 D.V., Mexico

C.R. Krishna Murti, v. Landa, Aly Massoud,

*Norton Nelson,

Blanca Ordonez,

Jiri Parizek,

International Programme on Chemical Safety, Division of Environmental Health, World Health Organization, I2Il Geneva 27, Switzerland XXVll

xxviii David Peakall,

Patrick Sheehan,

*Emmanuel Somers,

R. Truhaut,

*Member of the Executive Committee.

Short-term Toxicity Testsfor Non-genotoxic Effects

Head, Toxicology Section,National Wildlife ResearchCentre,CanadianWildlife Service,Ottawa, Ontario, Canada KiA OE7 Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada KiA OR6 Director General, Drugs Directorate, Health Protection Branch, Health and Welfare Canada, Health Protection Building, Tunney's Pasture, Ottawa, Ontario, Canada KiA OL2 Laboratoire de Toxicologie et d'Hygiene industrielle, Faculte des Sciences, Pharmaceutiques et Biologiques de Paris, Universite Rene Descartes, 4 avenue de I'Observatoire, 75006 Paris, France

Participants of the Workshop on Short-term Toxicity Tests for Non-genotoxic Effects D.K. Agarwal,

*Bernard Astill,

Donald Barltrop,

G.c. Beeking,

A. Berlin,

Philippe Bourdeau,

J.W. Bridges,

Martin Brueton,

Gordon C. Butler,

National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, Raleigh, North Carolina 27709, USA Health, Safety and Human Factors Laboratory, Eastman Kodak Company, 1669 Lake Avenue, Rochester, New York 14650, USA Department of Child Health, Westminster Medical School, University of London, Vincent Square, London SW1P 2NS, UK Interregional Research Unit, International Programme on Chemical Safety (IPCS), National Institute of Environmental Health Science, PO Box 12233, Research Triangle Park, Raleigh, North Carolina 27709, USA Health and Safety Directorate, Commission of European Communities, Plateau DE, Kirchberg L-2920, Luxemburg,OMEA Director of Environmental Research, Commission of the European Communities, Rue de la Loi 200, B-l049, Brussels, Belgium (Co-Chairman) Professor of Toxicology, Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH,UK Assistant Director, Department of Child Health, Westminster Medical School, University of London, Vincent Square, London SW1P 2NS, UK Director, Division of Biological Sciences, National Research Council afCanada, 100 Sussex Drive, Ottawa, Canada KiA OR6 XXIX

xxx

DavideCalamari,

Short-term Toxicity Tests for Non-genotoxic Effects

FacultyofAgriculture,UniversityofMilan,ViaCel. oria 2,20133 Milan, Italy

Neil Chernoff,

Director, Division of Reproductive and Developmental Toxicology, Health Effects Laboratory, MD-67, u.s. Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA

James Clark,

Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77003, USA

Jack H. Dean,

Head, Immunobiology Program and ImmunotoxicologylCell Biology Section, Chemical Industry Institute of Toxicology, PO Box /2137, Research Triangle Park, North Carolina 27709, USA

Robert L. Dixon,

Sterling-Winthrop Research Institute, Rensellaer, New York, USA

B. Ekwall,

Toxicology Laboratory, tion, Uppsala, Sweden

Nilda Fernicola,

Pan American Center for Human Ecology Health, Apartado Postal 249, Toluca, Mexico

Theodor Fliedner,

Rector, University of Ulm, D 79 Ulm, Federal Republic of Germany

J. Friedrich,

National

Food Administraand

Lehrstuhl fur Organische Chemie, T.v., Lichtenbergstr 4, 8046 Garching, Federal Republic of Germany

Silvio Garattini,

Direttore, Istituto di Ricerche Pharmacologiche, Mario Negri, Via Eritrea 62, Milan, Italy

James W. Gillett,

114 Fernow Hall, Cornell University, Department of Natural Resources, Ithaca, New York 14853-0188, USA

Alan Goldberg,

Department of Environmental Health Sciences, Johns Hopkins School of Hygiene, 615 N. Wolfe Street, Baltimore, Maryland 21205, USA

M.I. Gounar,

International Programme on Chemical Safety (IPCS), Division of Environmental Health, World Health Organization, /2Il Geneva 27, Switzerland

H. Heit,

University of Ulm, D 79 Ulm, Federal Republic of Germany

J.R. Hickman,

Director General, Environmental Health Directorate, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada KIA OL2

XXXI

Participants of the Workshop

Fina Kalayanova,

K. Khera,

C.R. Krishna Murti, Ralf Krowke,

V. Landa, B.V. Leonov,

Carlton Nadolney,

Director, Institute of Hygiene and Occupational Health, Academy of Medicine, Boul. D. Nestorov 15, Sofia 1431, Bulgaria General Toxicology Section, Food Directorate, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A OL2 SWAT/, 27, Dr. Radhakrishnan Salai, Mylapore, Madras 600 004, India Institute fur Toxikologie und Embryopharmakologie, Freie Universitiit Berlin, Garystr. 5, 1000 Berlin 33 , Federal Republic of Germany Czechoslovak Academy of Sciences, Institute of Entomology, Vinicna 7, Prague 2, Czechoslovakia Head, Laboratories for Experimental Embryology, All Union Research Institute of OBSIGYN, Elansky Street, Moscow 119435, USSR U.S. Environmental Protection Agency, Mail Drop RE 683, 401 M Street S.w., Washington, D.C. 20460, USA

Norton Nelson,

Institute for Environmental Medicine, New York University Medical Center, 550 First Avenue, New York, New York 10016, USA

*D. Neubert,

Institut fur Toxikologie und Embryopharmakologie der Freien Universitiit Berlin, Garysterasse 9, D-1000, Berlin 33, Federal Republic of Germany Environmental Advisory of the Minister of Health, Lopez Cotilla 739, COL del. Valle 03100 D.v., Mexico

B. Ordonez,

G. Pabst, Jiri Parizek,

D. Peakall,

G. Persoone,

Andrew Rowan,

University of Ulm, D 79 Ulm, Federal Republic of Germany International Programme on Chemical Safety, Division of Environmental Health, World Health Organization, 1211 Geneva 27, Switzerland Head, Toxicology Section, National Wildlife Research Centre, Canadian Wildlife Service, Ottawa, Ontario, Canada K1A OE7 Director, Laboratory for Biological Research in Environmental Pollution, State University of Ghent, 1. Plateaustraat 22, B-9000, Ghent, Belgium Assistant Dean, Tufts School of Veterinary Medicine, 203 Harrison Avenue, Boston, Massachusetts

02111,USA

XXXll

I.V. Sanockij,

Lauri Saxen, P. Sheehan,

*Vittorio Silano, Emmanuel Somers,

A.L. Stammati, Raymond Suskind,

Sonia Tabakova,

R. Truhaut,

*Ivar Ugi,

F.X.R. van Leeuwen, J.G. Vos,

Peter Wells,

F. Zucco,

*Did not attend Workshop.

Short-term Toxicity Testsfor Non-genotoxic Effects

Institute of Industrial Hygiene and Occupational Diseases, Academy of Medical Science of USSR, PROSP Budennoga 31, Moscow 105275, USSR University of Helsinki, Haartmaninkatu 3, 00290 Helsinki 29, Finland Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada KIA OR6 Istituto Superiore di Sanita, ViaIe Regina Elena 299, 00161 Rome, Italy Director General, Drugs Directorate, Health Protection Branch, Health and Welfare Canada, Health Protection Building, Tunney's Pasture, Ottawa, Ontario, Canada KIA OL2(Co-chairman) Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy University of Cincinnati Medical Center, Institute of Environmental Health, Kettering Laboratory (#56), 3223 Eden Avenue, Cincinnati, Ohio 45267, USA Institute of Hygiene and Occupational Health, Academy of Medicine, Boul. D. Nestorov 15, Sofia 1431, Bulgaria Laboratoire de Toxicologie et d' Hygiene Industrielle, Faculte des Sciences, Pharmaceutiques et Biologiques de Paris, Universite Rene Descartes, 4 avenue de l'Observatoire, 75006 Paris, France Lehrstuhl fur Organische Chemie, T.U., Lichtenbergstr 4, 8046 Garching, Federal Republic of Germany National Institute of Public Health, PO Box I, Bilthoven, The Netherlands National Institute of Public Health and Environmental Protection, PO Box I, Bilthoven, The Netherlands Toxic Chemicals Management Center, Environment Canada, Fiace Vincent Massey, 351 St. Joseph Boulevard, Hull, Quebec, Canada KIA IC8 Istituto di Tecnologie Biomediche, CNR., Rome, Italy