Saturday, October 22, 2016 7:45 - 8:30 8:30 - 8:45

8:45 - 9:00

9:00 - 9:20

9:20 - 10:30

Registration | Continental Breakfast | Exhibitors | Research Poster Hall 8:30 – 1:00 PLENARY SESSIONS Welcome and Opening Remarks from Brain Tumour Foundation of Canada Masters of Ceremony: Dr. Kenneth Shonk Dr. Shonk has been a public speaker for over 20 years and has given over 700 talks to approximately 150,000 people. His focus is on healthy humour and he will demonstrate that pain in life is inevitable but suffering is optional. Personal Story of Hope: Steve and Iris Rawlings Stephen was diagnosed with an anaplastic oligodendroglioma (grade III) in November of 2015 at the age of 53 years old, and will share his personal experiences through diagnosis and treatment including an awake craniotomy; while Iris, an emergency room nurse, will share her personal experience as a caregiver not only to her husband but to their daughter who was diagnosed with a pineal adenoma tumour (grade I) eight years ago. The Rawlings story is one of hope, support and perseverance. Brain Tumour Foundation of Canada Keynote Research Recipients Supporting brain tumour research in Canada allows each of us to both better understand this disease and to move closer to finding new treatments, improving current treatments, and enhancing the quality of life for people affected by a brain tumour. The following physicians are recipients of Brain Tumour Foundation of Canada’s research grant programs: “How Genetics Impact your Child's Brain Cancer Journey” Dr. Sorana Morrissy, Senior Post-Doctoral Fellow, SickKids, Toronto, ON Pediatric Brain Cancer Impact Grant Dr. Morrissy is a representative of Dr. Michael Taylor’s team at SickKids Medulloblastoma is the most common brain cancer of childhood, and despite very aggressive toxic therapy is a major cause of pediatric cancer death in Canada. Thus, innovative strategies are needed to improve the quality of life for families of children with brain tumours and to increase survival rates. Specifically, we hope to develop more effective, personalized, and molecularly targeted therapies, using information gained from genetic analysis of individual patient tumors. However, growing evidence from adult cancers suggests that different geographical areas within the same tumour are biologically very dissimilar, and that these regions can respond differently even to targeted treatments. Indeed, if a new drug is going to be effective in the clinic, it is paramount that we know if a target of that drug is present in all pieces of a tumor. Thus, we sought to evaluate the geographical differences in pediatric brain tumors by analyzing several biopsies from the same patient at the time of their surgery. Our results provide a new insight into whether biological pathways are geographically stable, and how many biopsies are required for a clinically-relevant genomic-based understanding of tumor biology. “Exploring the Effects of Radiation and its Impact on Metastatic Brain Cancer” Dr. Paula Foster, Scientist/Associate Professor, Medical Biophysics, University of Western Ontario/Robarts Research Institute 2015 Research Grant Recipient Prophylactic RT is a standard treatment for all small cell lung cancer patients with response to chemotherapy to prevent the development of metastatic brain tumours, and it is now being considered for some breast cancer patients. Unfortunately RT has been shown to have multiple negative consequences in normal brain tissue including radio necrosis (tissue death), cognitive deficits and both short and long term neuro-inflammation. The purpose of this project is to investigate the impact of RT on brain metastases and dormant cancer cells and the influence that radiation-induced damage has on the growth of metastatic brain cancer.

“Mindfulness and Brain Tumours: Finding Your Way Through The Storm” Dr. Steven Selchen, Psychiatry, Sunnybrook Research Institute Dr. Janet Ellis, Medical Psychiatrist Sunnybrook Health Sciences Centre 2015 Research Grant Recipients Brain tumour survivors often experience ongoing psychological distress and decreased wellbeing. This can often go underestimated and untreated, reducing survivors’ quality of life and increasing the burden on caregivers and loved-ones. Unfortunately, there has been little research to-date on therapy options for survivors. However, recent literature suggests a role for Mindfulness-Based Interventions (MBIs) in improving outcomes in this population. MBIs combine eastern meditative practices with western psychotherapeutic approaches to help individuals cope more effectively with their difficulties. We will discuss the potential of Mindfulness to reduce distress and enhance wellbeing in brain tumour survivors, which we are exploring in our BTFC-funded research study. 10:30 – 10:50 10:50 – 11:50

Break | Exhibitors | Research Poster Hall “I don’t want to get high, I want to get help!” Understanding Medicinal Cannabis Keynote Speaker: Dr. David Hepburn Dr. Dave Hepburn is an award winning syndicated columnist to more than 100 newspapers across the United States and Canada. He is a recipient of the prestigious Canadian Community Newspaper Association columnist of the year award as well as the Arizona Newspaper Association columnist of the year. He is the author of "The Doctor Is In(sane)" which was nominated for several book awards. Cohost of the Oprah Winfrey Network show Buyologic and was the cohost of the popular national radio program "Wisequacks". Dr. David Hepburn MD wants to help educate Canadian doctors and the general community about the potential uses of medical cannabis. This presentation will review the role medical cannabis plays on certain illnesses and the current research available on medicinal cannabis.

11:50 – 12:10

12:10 – 1:00

1:00 – 1:20

Update from Brain Tumour Foundation of Canada Susan Marshall, CEO Video & Update Lunch | Exhibitors | Research Poster Hall 1:00 – 2:20 CONCURRENT SESSIONS Outline of concurrent sessions available at the end of this document Advancing the The New From Caring to Our Future – The Understanding Normal – What Caregiving Road Ahead for of Tumours and Now? Pediatric Brain Treatment Tumours “A New Era in “Physical, “Taking Care “Navigating the Treatment Cognitive and of You” School and Rosie Cashman, Friends after of Brain Psychosocial Nurse Tumours” Rehabilitation Pediatric Brain Practitioner & Dr. Catherine Following a Tumour Suzanne Heft, Maurice, Brain Tumour” Treatment” Caregiver Neuro-Oncologist Ilyse Lax, Dr. Sharon Guger, Rehabilitation Neuropsychologist Consultant, Occupational Therapist

Students, Research & Science – Oh My!

Moderator: Claire Snyman Teams from: - McMaster University - University of Toronto - Queens University Panelists: - Dr. Joe Megyesi - Dr. Chris Wynder

This session will serve as a mock undergraduate research competition 1:20 – 1:30 1:30 – 1:50

1:50 – 2:00 2:00 – 2:20 2:20 – 2:35 2:35 – 3:35

“Surgical Management of Adult Low and High Grade Gliomas” Dr. Paul Kongkham, Neurosurgeon

“Advance Care Planning: It's How we Care for Each Other” Louise Hanvey, Speak Up

“Early Grief as Part of the Grieving Process” Jennifer ThompsonCroft, Social Worker

“Parenting through Transitions: How Health Issues and the Teen Years can Complicate the Job” Dr. Joel Tourigny, Pediatric Psychologist

Competition continued

Panel Panel Panel Panel Panel Break | Back to Plenary Room 2:35 – 4:30 PLENARY SESSION Clinical Trials & Patient Panel This session will provide information about the current landscape of clinical trials within the brain tumour population in Canada, focusing both on challenges and successes within our research centres. Patients who have been a part of various clinical trials will share their own experiences, providing invaluable feedback around the importance of the patient perspective in clinical trial designs. Moderator: Dr. Sten Myrehaug, Radiation Oncologist, Odette Cancer Centre, Sunnybrook Health Sciences Centre Panelists: - Steve Mazza, diagnosed with an Anaplastic Astrocytoma (grade II) and had experience with a clinical trial comparing Dexmedetomidine and Propofol-remifentanil Conscious Sedation for awake Craniotomy for Tumor Surgery -

Denis Raymond, glioblastoma multiforme (GBM) (grade IV) survivor, and participant in the Optune in conjunction with Temozolomide clinical trial from August 2013 to march 2016

3:35 – 4:15

Dr. Kenneth Shonk – Healthy Humour Dr. Shonk will provide a brief summary of the history, physiology, anatomy, biochemistry, classification and uses of humour. He will then focus on using humour in dealing with serious illnesses, caregiver burnout, improving communication with health care professionals and even death and dying. All of this liberally sprinkled with lousy jokes, puns and anecdotal stories from 40 + years of medical practice.

4:15 – 4:30

Closing Remarks

Outline of Concurrent Sessions Concurrent Stream #1: Advancing the Understanding of Tumours and Treatment “A New Era in the Treatment of Brain Tumours” Dr. Catherine Maurice, Neuro-Oncologist, University Health Network, Toronto, ON This presentation will focus on the current standard of care for the treatment of glial brain tumours, new drugs currently studied in trials and their mechanism of action and why those recent molecules are promising for the future of brain tumours treatment. “Surgical Management of Adult Low and High Grade Gliomas” Dr. Paul Kongkham, Neurosurgeon, University of Toronto & Toronto Western Hospital, Toronto, ON This presentation will review the criteria as to who is a candidate for surgery, surgical strategies, decision making, and operative technologies to assist in safe resection of a brain tumour. Panelist: Dr. Catherine Maurice, Dr. Paul Kongkham, and Dr. David Hepburn

Concurrent Stream #2: The New Normal – What Now? “Physical, Cognitive and Psychosocial Rehabilitation Following a Brain Tumour” Ilyse Lax, Rehabilitation Consultant, Occupational Therapist, Pencer Brain Tumor Centre & Princess Margaret Hospital, Toronto, ON People who have been diagnosed with a primary brain tumour and undergo treatments experience a range of physical, cognitive and psychosocial effects which impact on their independence, safety and quality of life. These concerns may be addressed through rehabilitation intervention. Despite advances in the medical treatment of brain tumours, rehabilitation for this population has not gained similar momentum. Timely and individualized rehabilitation services over the course of the disease process is beneficial. This presentation will describe an innovative rehabilitation consultation model of care currently integrated into outpatient neuro-oncology treatment for persons and their loved ones who are affected by a primary brain tumour. “Advance Care Planning: It's how we Care for Each Other” Louise Hanvey, Director, Advance Care Planning in Canada, Canadian Hospice Palliative Care Association, Ottawa, ON Advance care planning is the process of reflecting on values, beliefs and wishes for future health and personal care, and having conversations. Advance care planning includes deciding on a substitute decision maker - or the person who would speak on your behalf if you could not make your own decisions about your medical and personal care. This presentation will explore why advance care planning is important for everyone - but particularly for those who have been diagnosed with a brain tumour. The presentation will walk through the steps of advance care planning with practical suggestions about the kinds of questions that need to be considered and how to have the conversations. Participants will learn about important resources that they can use to engage in advance care planning. Panelist: Ilyse Lax & Louise Hanvey

Concurrent Stream #3: From Caring to Caregiving “Taking Care of You” Rosemary Cashman, Nurse Practitioner, BC Cancer Agency, Vancouver, BC and Suzanne Heft, widow of a brain tumour patient who was treated in Toronto and has written articles on caregiving Participants will learn ways to effectively manage and reduce personal stress related to caregiving, while exploring self-care strategies. “Early Grief as Part of the Grieving Process” Jennifer Thompson-Croft, Social Worker, The Ottawa Hospital Psychosocial Oncology Program, Ottawa, ON Nearly everyone involved in caring for a loved ones experiences grief. Caregivers grieve the loss – the loss of function, the loss of independence and sometimes the loss of personality. Learn more about how to cope with early grief

Panelist: Rosie Cashmen, Suzanne Heft and Jennifer Thompson-Croft

Concurrent Stream #4: Our Future – The Road Ahead for Pediatric Brain Tumours “Navigating School and Friends After Pediatric Brain Tumour Treatment” Dr. Sharon Guger, Neuropsychologist, SickKids, Toronto, ON Returning to school after treatment can signal a return to a normal routine. While some survivors of pediatric brain tumours embrace this return, others experience frustration with learning and/or peers. This presentation will review common challenges faced by students and parents upon returning to the classroom. Strategies on how to support children academically and socially will be reviewed. As well, collaboration with educators and self-advocacy will also be discussed. “Parenting through Transitions: How Health Issues and the Teen Years can Complicate the Job” Dr. Joel Tourigny, Pediatric Psychologist, SickKids, Toronto, ON Parenting children and teens as they transition to a new school, new home, or new living arrangement can be difficult enough. When a child has a significant health issue, such as recovery from a pediatric brain tumour to work through, it can make the job of parenting seem unmanageable at times. This presentation will review some of the common challenges facing parents today and examine these challenges through the lens of rehab and recovery. We will discuss the added challenge of parenting children with chronic health issues and highlight strategies that help children thrive. Panelist: Dr. Sharon Guger, Dr. Joel Tourigny, and Dr. Sorana Morissy

Concurrent Stream #5: Students, Research & Science – Oh My! This session will serve as a mock undergraduate research competition to promote scientific innovation among undergraduate students and provide them with the opportunity to present their work to scientists, professionals, and others relevant in the field of brain tumour research for review. Moderator: Claire Snyman Panelist: Dr. Joseph Megyesi, Dr. Chris Wynder Four Teams: McMaster University (x1), University of Toronto (x2), and Queens University (x1)