Research Knowledge Forum Tumor

Research Knowledge Forum Tumor 2015-Q3 Report Page 1 of 17 Steering Committee Charles Fisher (Chairman) University of British Columbia Vancouver,...
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Knowledge Forum Tumor 2015-Q3 Report

Page 1 of 17

Steering Committee

Charles Fisher (Chairman) University of British Columbia Vancouver, BC, Canada Start of Term: 01 Mar 2014 End of Term: 28 Feb 2017

Stefano Boriani Rizzoli Institute Bologna, Italy Start of Term: 01 Jan 2012 End of Term: 31 Dec 2017

Ziya Gokaslan The Warren Alpert Medical School of Brown University Providence, RI, USA Start of Term: 01 Mar 2014 End of Term: 28 Feb 2017

Peter Pal Varga National Center for Spinal Disorders Budapest, Hungary Start of Term: 01 Jan 2012 End of Term: 31 Dec 2017

Laurence Rhines The University of Texas MD Anderson Cancer Center Houston, TX, USA Start of Term: 01 Jan 2012 End of Term: 31 Dec 2017

Chetan Bettegowda Johns Hopkins University School of Medicine Baltimore, MD, USA Start of Term: 01 Jul 2012 End of Term: 30 Jun 2018

Norio Kawahara Kanazawa Medical University Kahoku-gun, Japan Start of Term: 01 Jan 2012 End of Term: 31 Dec 2017

Arjun Sahgal Sunnybrook Health Sciences Center Toronto, ON, Canada Start of Term: 24 Mar 2014 End of Term: 30 Mar 2017

Knowledge Forum Manager Niccole Germscheid AOSpine International Clavadelerstrasse 8 7270 Davos Switzerland T +41 81 414 27 34

[email protected]

Page 2 of 17

Projects SINS (Spine Instability Neoplastic Score) Title: Interdisciplinary validity and reliability of the SINS instability score in radiologists and radiation oncologists

Aim: To assess the inter- and intra-observer reliability and validity of SINS in radiation oncologists and radiologists

Principal Investigator:

Publication Goal: 2 Manuscripts

Charles Fisher

Participating Sites: Local Investigator Institute

City

Country

Region

Charles

University of British Columbia, Vancouver General Hospital

Vancouver

Canada

NA

Gokaslan

Ziya

Johns Hopkins University School of Medicine

Baltimore

USA

NA

Boriani

Stefano

Rizzoli Institute

Bologna

Italy

EU

Varga

Peter Pal

National Center for Spinal Disorders

Budapest

Hungary

EU

Rhines

Laurence

The University of Texas MD Anderson Cancer Center

Houston

USA

NA

Kawahara

Norio

Kahoku-gun

Japan

AP

Fourney

Daryl

Kanazawa Medical University University of Saskatchewan Royal University Hospital

Saskatoon

Canada

NA

Reynolds

Jeremy

Oxford University Hospital NHS Trust

Oxford

UK

EU

Fehlings

Michael

University of Toronto, Toronto Western Hospital

Toronto

Canada

NA

Last

First

Fisher

Collaborating Radiologists and Radiation Oncologists: Region

Number

Asia Pacific

12

Europe

25

North America

33

Publications: • 8 Abstracts presented (5 oral, 3 poster) • 2 Manuscripts published: − 1 in the American Journal of Roentgenology − 1 in Radiation Oncology Awards & Nominations: None Status: Completion

Page 3 of 17

Primary Tumor Retrospective Title: Predictors of mortality and morbidity in the surgical management of primary tumors of the spine: a multi-center retrospective cohort study with a cross-sectional survival check.

Aim: To determine what variables (clinical, diagnostic, therapeutic, or demographic) are associated with local recurrence and survival within defined groups of primary malignant and benign bone and soft tissue spine tumors.

Principal Investigator: Charles Fisher Co-Principal Investigator:

Ziya Gokaslan

1.

Overall Analysis—analysis of the complete collection.

2.

Histotype Analysis—analysis of each tumor histotype. Each histotype (13 identified) will undergo a separate analysis by assigned project members

Publication Goal: 14 Manuscripts Participating Sites: Local Investigator Institute

City

Country

Region

Charles

University of British Columbia, Vancouver General Hospital

Vancouver, BC

Canada

NA

Gokaslan

Ziya

Johns Hopkins University School of Medicine

Baltimore, MD

USA

NA

Boriani

Stefano

Rizzoli Institute

Bologna

Italy

EU

Varga

Peter Pal

National Center for Spinal Disorders

Budapest

Hungary

EU

Rhines

Laurence

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

NA

Reynolds

Jeremy

Oxford University Hospital NHS

Oxford

UK

EU

Fehlings

Michael

University of Toronto, Toronto Western Hospital

Toronto, ON

Canada

NA

Bilsky

Mark

Memorial Sloan-Kettering Center

New York, NY

USA

NA

Dekutoski

Mark

The CORE Institute

Pheonix, AZ

USA

NA

Luzzati

Alessandro

Istituto Ortopedico Galeazzi

Milan

Italy

EU

Williams

Richard

Princess Alexandra Hospital

Brisbane

Australia

AP

Chou

Dean

University of California San Francisco

San Francisco, CA

USA

NA

Quraishi

Nasir

Queens Medical Centre, Nottingham University Hospital NHS Trust

Nottingham

UK

EU

Last

First

Fisher

Publications: • 1 Abstract submitted • 1 Abstract accepted (oral) • 51 Abstracts presented (41 oral, 10 poster) • 2 Manuscripts submitted • 3 Manuscripts accepted − 2 in Spine − 1 in the Journal of Neurosurgery: Spine • 6 Manuscripts published: − 1 in Spine − 1 in the European Spine Journal − 2 in the Journal of Neurosurgery: Spine − 1 in the Journal of Neuro-Oncology − 1 in the Evidence Based Spine Journal

Awards & Nominations: • Nominated for the Whitecloud Award for Best Clinical Paper at the 22nd International Meeting on Advanced Spine Techniques (IMAST) 2015. • Invited by the Editor of Neurosurgery to submit a manuscript about mobile chordoma (2014). • Nominated for the EuroSpine Full Paper Award 2014 & presented as "Best of Show" papers (the highest scoring abstracts session) at EuroSpine 2014. • Nominated for a value added award at the NASS 28th Annual Meeting 2013. • Awarded best paper at the 11th Annual AOSpine North America Fellows Forum 2013 where the abstract will be published in the Evidence Based Spine Journal. Status: Disseminating

Page 4 of 17

FFPE Chordoma (an extension of Primary Tumor Retrospective) Title: An analysis of the role of the single nucleotide polymorphism rs2305089 in retrospectively collected chordomas. Principal Investigator: Chetan Bettegowda Co-Principal Investigator: Stephen Yip

Aim: To determine the role that the SNP rs2305089 has in the prognosis of chordoma patients by evaluating whether or not there is a relationship between the status of the SNP and various clinical outcomes/measures (e.g., survival, local recurrence, response to radiation therapy, response to chemotherapy, link to metastasis, demographics). Publication Goal: 1 Manuscript

Participating Sites: Local Investigator Last

Institute

City

Country

Region

First

Bettegowda

Chetan

Johns Hopkins University School of Medicine

Baltimore, MD

USA

NA

Gokaslan

Ziya

Johns Hopkins University School of Medicine

Baltimore, MD

USA

NA

Varga

Peter Pal

National Center for Spinal Disorders

Budapest

Hungary

EU

Lazary

Aron

National Center for Spinal Disorders

Budapest

Hungary

EU

Rhines

Laurence

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

NA

Wang

Billy

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

NA

Lazar

Alexander

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

NA

Fisher

Charles

University of British Colombia, Vancouver General Hospital

Vancouver, BC

Canada

NA

Yip

Stephen

University of British Columbia, Vancouver General Hospital

Vancouver, BC

Canada

NA

Boriani

Stefano

Rizzoli Institute

Bologna

Italy

EU

Gambarotti

Marco

Rizzoli Institute

Bologna

Italy

EU

Publications: • 1 Abstract accepted (oral) • 5 Abstracts presented (4 oral, 1 poster) • 1 Manuscript submitted

Awards & Nominations: None Status: Disseminating

Page 5 of 17

TERT (an extension of Primary Tumor Retrospective) Title: An analysis of the role of the TERT promoter mutations in retrospectively collected primary spinal column tumors.

Aim: To determine the rates of TERT promoter mutation (mutation of the promoter of the telomerase gene [23348506,23348503]) and its prognostic significance in primary spinal column tumors.

Principal Investigator: Chetan Bettegowda Publication Goal: 1 Manuscript Co-Principal Investigator: Ziya Gokaslan

Participating Sites: Local Investigator Last

Institute

City

Country

Region

First

Bettegowda

Chetan

Johns Hopkins University School of Medicine

Baltimore, MD

USA

NA

Gokaslan

Ziya

Johns Hopkins University School of Medicine

Baltimore, MD

USA

NA

Varga

Peter Pal

National Center for Spinal Disorders

Budapest

Hungary

EU

Lazary

Aron

National Center for Spinal Disorders

Budapest

Hungary

EU

Rhines

Laurence

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

NA

Wang

Billy

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

NA

Lazar

Alexander

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

NA

Fisher

Charles

University of British Colombia, Vancouver General Hospital

Vancouver, BC

Canada

NA

Yip

Stephen

University of British Columbia, Vancouver General Hospital

Vancouver, BC

Canada

NA

Ng

Tony

University of British Columbia, Vancouver General Hospital

Vancouver, BC

Canada

NA

Boriani

Stefano

Rizzoli Institute

Bologna

Italy

EU

Gambarotti

Marco

Rizzoli Institute

Bologna

Italy

EU

Clarke

Michelle

Mayo Clinic

Rochester, MN

USA

NA

Dekutoski

Mark

The CORE Institute

Phoenix, AZ

USA

NA

Publications: • Abstracts: 0 • Manuscripts: 0

Awards & Nominations: None Status: Executing – data collection Page 6 of 17

PTRON (Module within Spine ReCORD) Title: Primary Tumor Research and Outcome Network (PTRON): a multicenter prospective registry for the management of primary tumors of the spine. Principal Investigator: Charles Fisher Co-Principal Investigators: Ziya Gokaslan, Laurence Rhines Aim: To prospectively investigate the prognostic variables (clinical, diagnostic, and therapeutic) within subgroups of patients diagnosed with primary spinal column tumors that are associated with survival, local recurrence, perioperative morbidity, and patient reported outcomes. Publication Goal: To be defined Participating Sites: To be defined Publications: • Abstracts: 0 • Manuscripts: 0 Awards & Nominations: None

Status: Planning

Page 7 of 17

EPOSO Title: The epidemiology, process and outcomes of spine oncology (EPOSO). Principal Investigator: Charles Fisher

Aim: The main purpose of this study is to utilize a comprehensive, prospective clinical database to collect patient, diagnostic and treatment variables along with disease specific and generic health related quality of life (HRQOL) data on consecutively treated patients with metastatic spine tumors.

Co-Principal Investigator: Ziya Gokaslan Publication Goal: 3 manuscripts

Participating Sites: Local Investigator Institute

City

Country

Region

Charles

University of British Colombia, Vancouver General Hospital

Vancouver, BC

Canada

NA

Arnold

Paul

Kansas University Medical Center

Kansas City, MO

USA

NA

Clarke

Michelle

Mayo Clinic

Rochester, MN

USA

NA

Fehlings

Michael

University of Toronto, Western Hospital

Toronto, ON

Canada

NA

Rhines

Laurence

The University of Texas MD Anderson Cancer Center

Houston, TX

USA

NA

Sahgal

Arjun

Sunnybook Health Sciences Center

Toronto, ON

Canada

NA

Sciubba

Daniel

Johns Hopkins University School of Medicine

Baltimore, MD

USA

NA

Schuster

James

Hospital of the University of Pennsylvania

Philadelphia, PA

USA

NA

Varga

Peter

National Center for Spinal Disorders

Budapest

Hungary

EU

Weber

Michael

Montreal General Hospital

Montreal, QC

Canada

NA

Last

First

Fisher

Publications: • Abstracts: 0 • Manuscripts: 0

Awards & Nominations: This project is co-funded by the Orthopaedic Research & Education Foundation (OREF) through a Spine Prospective Clinical Research Grant. Status: Executing – data collection

Page 8 of 17

Systematic Reviews Title: Systematic reviews about the outcomes of surgical treatment of metastases to the spine and primary tumors of the spine. Principal Investigator: Charles Fisher Co-Principal Investigators: Michelle Clarke, Daniel Sciubba, and Daryl Fourney

Aim: To perform a systematic review of the literature for prognostic factors specific to: 1) surgical treatment of prostate metastases to the spine 2) surgical treatment of breast metastases to the spine 3) surgical treatment of renal cell metastases to the spine 4) surgical treatment of lung metastases to the spine 5) symptomatic vertebral hemangioma To perform a systematic review of the literature for the management of malignant primary tumors of the spine. Publication Goal: 5 manuscripts

Publications: • 9 Abstracts presented (8 oral, 1 poster) • 2 Manuscripts submitted

Awards & Nominations: None Status: Reporting

Bone Graft Title: Bone grafting practices in spine oncology Principal Investigator: Raja Rampersaud

Aim: To determine the optimal structural bone graft for reconstruction following surgical treatment of primary and metastatic spine tumors through the best available evidence and expert opinion.

Co-Principal Investigators: Charles Fisher Publication Goal: 2 manuscripts Publications: • 2 Abstracts presented (all oral) • Manuscripts: 0

Awards & Nominations: None Status: Reporting

Spine Oncology Focus Issue Title: Spine Oncology Focus Issue Principal Investigator: Charles Fisher

Aim: To product a Spine Oncology Focus Issue which synthesizes the best available evidence and expert opinion in the management of primary spinal column tumors and metastatic spine disease. Publication Goal: 15 manuscripts

Publications: • Manuscripts: 0

Awards & Nominations: None Status: Planning

Page 9 of 17

Publication Summary Abstracts Submitted (under review) 1.

Versteeg AL, Dea N, Boriani S, Varga PP, Luzzati A, Fehlings MG, Bilsky MH, Rhines LD, Reynolds JJ, Dekutoski MB, Gokaslan ZL, Germscheid NM, Fisher CG. Surgical management of spinal osteoblastoma. Global Spine Congress 2016, Dubai, United Arab Emirates, April 13-16, 2016.

Accepted for Presentation Podium Presentations: 1.

Gokaslan ZL, Zadnik P, Sciubba DM, Germscheid N, Goodwin CR, Wolinsky J-P, Bettegowda C, Groves M, Luzzati A, Rhines L, Fisher C, Varga PP, Dekutoski MB, Clarke M, Fehlings MG, Quraishi NA, Chou D, Reynolds JJ, Williams R, Boriani S. Mobile spine chordoma: results of 166 patients from the AOSpine Knowledge Forum Tumor. North American Spine Society (NASS) 2015, Chicago, USA, October 14-17, 2015.

Poster Presentations: 1.

N/A

Presented Podium Presentations: 1.

2.

3.

4.

5.

Varga PP, Gokaslan ZL, Fisher C, Boriani S, Wang W-L, Lazary A, Germscheid N, Bettegowda C, Yip S, Rhines LD. Prognostic significance of T gene SNP rs2305089 in individuals with spinal column chordoma. Scoliosis Research Society (SRS) 50th Annual Meeting & Course, Minneapolis, MN, USA, September 30-October 3, 2015. Gokaslan ZL, Zadnik P, Sciubba DM, Germscheid N, Goodwin CR, Wolinsky J-P, Bettegowda C, Groves M, Luzzati A, Rhines L, Fisher C, Varga PP, Dekutoski MB, Clarke M, Fehlings MG, Quraishi NA, Chou D, Reynolds JJ, Williams R, Boriani S. Mobile spine chordoma: results of 166 patients from the AOSpine Knowledge Forum Tumor. 22nd International Meeting on Advanced Spine Techniques (IMAST), Kuala Lumpur, Malaysia, July 8-11, 2015. Rhines LD, Dirks MS, Boriani S, Luzzati A, Fehlings MG, Fisher CG, Dekutoski MB, Williams R, Quraishi NA, Gokaslan ZL, Bettegowda C, Germscheid N, Varga PP. Ewing's sarcoma of the spine: survival and local control in surgically treated patients. 22nd International Meeting on Advanced Spine Techniques (IMAST), Kuala Lumpur, Malaysia, July 8-11, 2015. Fisher CG, Versteeg AL, Dea N, Boriani S, Varga PP, Dekutoski MB, Luzzati A, Gokaslan ZL, Williams RP, Reynolds JJ, Fehlings MG, Bettegowda C, Rhines LD. Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality in a multicenter study. 22nd International Meeting on Advanced Spine Techniques (IMAST), Kuala Lumpur, Malaysia, July 8-11, 2015. Clarke MJ, Dekutoski MD, Luzzati A, Rhines LD, Varga PP, Rose P, Fisher CG, Chou D, Fehlings MG, Reynolds JJ, Williams R, Quraishi NA, Germscheid NM, Sciubba D, Gokaslan ZL, Boriani S. Osteosarcoma of the spine:

prognostic variables for local recurrence and overall survival, a multi-center ambispective study. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015. 6.

Versteeg AL, Fisher CG, Boriani S, Varga PP, Dekutoski MB, Luzzati A, Gokaslan ZL, Williams RP, Reynolds JJ, Fehlings MG, Bettegowda C, Rhines LD. Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality in a multicenter study. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.

7.

Rhines LD, Dirks MS, Boriani S, Luzzati A, Fehlings MG, Fisher CG, Dekutoski MB, Williams R, Quraishi NA, Gokaslan ZL, Bettegowda C, Germscheid NM, Varga PP. Ewing's sarcoma of the spine: prognostic variables for survival and local control in surgically treated patients. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.

8.

Varga PP, Szövérfi Z, Lazary A, Gokaslan Z, Fisher C, Boriani S, Dekutoski M, Chou D, Quraishi N, Fehlings M, Rhines L. Prognostic variables for local recurrence and overall survival after surgical treatment of sacral chordoma – an analysis from AOSpine Tumor Knowledge Forum Primary Spinal Tumor Retrospective Database. Global Spine Congress 2015, Buenos Aires, Argentina, May 2023, 2015.

9.

Sciubba D, Yurter A, Ju D, Gokaslan Z, Fisher C, Rhines L, Fehlings M, Fourney D, Mendel E, Laufer I, Bettegowda C, Goodwin CR, Patel S, Rampersaud R, Reynolds J, Chou D, Weber M, Clarke M. A systematic review of clinical outcomes and prognostic factors for patients undergoing surgery for spinal metastases secondary to breast cancer. Global Spine Congress 2015, Buenos Aires, Argentina, Page 10 of 17

May 20-23, 2015. 10. Varga P, Lo S, Puvaneserajah V, Fisher C, Rhines L, Boriani S, Lazary A, Wang W-L, Gambarotti M, Germscheid NM, Yip S, Gokaslan Z, Bettegowda C. Prognostic significance of T gene SNP rs2305089 in individuals with spinal column chordoma. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015. 11. Goldstein CL, Varga PP, Gokaslan ZL, Boriani S, Luzzati A, Rhines L, Fisher CG, Chou D, Williams RP, Dekutoski MB, Quraishi NA, Bettegowda C, Kawahara N, Fehlings MG. Outcomes of surgical management and risks of recurrence of symptomatic spinal hemangiomas: a multicenter series of 68 cases. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015. 12. Zamorano JJ, Fehlings MG, Nater A, Tetreault L, Varga P, Gokaslan ZL, Boriani S, Fisher CG, Rhines LD, Bettegowda C, Kawahara N, Chou D. Risk factors for local recurrence after surgical resection of spine schwannomas: retrospective analysis of 169 patients from a multicenter international database. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015. 13. Lazary A. Local recurrence and overall survival after surgical treatment of sacral chordoma – an analysis of prognostic variables from AOSpine Knowledge Forum Primary spinal tumor retrospective database. 11th International Turkish Spine Congress, Cesme, Turkey, April 29-May 3, 2015. 14. Sewell M. Prognostic factors in the operative management of sacral chordomas. Spine Society of Australia, 26th Annual Scientific Meeting, Canberra, Australia, April 1012, 2015. 15. Sewell M. Systematic review of en bloc resection in the management of Ewing's sarcoma of the mobile spine with respect to local control and disease free survival. Spine Society of Australia, 26th Annual Scientific Meeting, Canberra, Australia, April 10-12, 2015. 16. Williams R, Sowman B, Boriani S, Varga PP, Luzzati A, Gokaslan ZL, Fehlings MG, Fisher CG, Dekutoski MB, Rhines LD, Reynolds J, Bettegowda C, Kawahara N, Quraishi NA. Spinal osteoid osteoma: a multicenter retrospective cohort study comparison of results with appendicular osteoid osteoma. British Association of Spine Surgeons (BASS) 2015, Bath, UK, March 18-20, 2015. 17. Williams R, Sewell M, Varga PP, Quraishi N. Systematic review of en bloc resection in the management of Ewing's sarcoma of the mobile spine with respect to local control and disease free survival. British Association of Spine Surgeons (BASS) 2015, Bath, UK, March 18-20, 2015. 18. Varga P, Szövérfi Z, Gokaslan Z, Fisher C, Boriani S, Dekutoski M, Chou D, Quraishi N, Fehlings M, Rhines L. Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival. British Association of Spine Surgeons (BASS) 2015, Bath, UK, March 18-20, 2015. 19. Varga PP, Szövérfi Z, Gokaslan Z, Fisher C, Boriani S, Dekutoski M, Chou D, Quraishi N, Fehlings M, Rhines L. Prognostic variables for local recurrence and overall survival after surgical treatment of sacral chordoma an analysis from AOSpine Tumor Knowledge Forum primary

spinal retrospective database. EuroSpine 2014, Lyon, France, October 1-3, 2014. 20. Clarke MJ, Varga PP, Rhines LD, Fisher CG, Chou D, Quraishi NA, Fehlings MG, Gokaslan ZL, Boriani S. Primary osteosarcomas of the spine: a multicenter review of 57 surgical cases. EuroSpine 2014, Lyon, France, October 1-3, 2014. 21. Boriani S, Lo SL, Puvanesarajah V, Chou D, Fisher CG, Rhines LD, Williams R, Varga PP, Szövérfi Z, Bettegowda C. Aneurysmal bone cysts of the spine: treatment options and considerations. EuroSpine 2014, Lyon, France, October 1-3, 2014. 22. Varga PP, Fisher CG, Rhines LD, Boriani S, Lazary A, Wang W-L, Germscheid N, Yip S, Bettegowda C. Prognostic significance of T gene SNP rs2305089 in individuals with spinal column chordoma. EuroSpine 2014, Lyon, France, October 1-3, 2014. 23. Quraishi NA, Boriani S, Varga PP, Luzzati A, Gokaslan ZL, Fehlings MG, Fisher CG, Rhines LD, Reynolds JJ, Williams R. A multicenter retrospective cohort study of spinal osteoid osteomas: surgical treatment and local recurrence results. EuroSpine 2014, Lyon, France, October 1-3, 2014. 24. Goldstein CL, Varga PP, Gokaslan ZL, Boriani S, Luzzati A, Rhines LD, Fisher CG, Chou D, Quraishi NA, Fehlings MG. Hemangiomas of the spine: results of surgical management and prognostic variables for local recurrence and mortality in a multicenter study. EuroSpine 2014, Lyon, France, October 1-3, 2014. 25. Varga P, Macki M, Bydon M, Sciubba DM, Wolinsky JP, Fisher CG, Reynolds JJ, Rhines LD, Chou D, Szövérfi Z, Gokaslan ZL. Long-term outcomes in primary, spinal osteochondroma: a multicenter study of 27 patients. EuroSpine 2014, Lyon, France, October 1-3, 2014. 26. Varga PP, Dirks MS, Rhines LD, Boriani S, Luzzati A, Fehlings MG, Fisher CG, Dekutoski MB, Williams RP, Gokaslan ZL. Ewing’s sarcoma of the spine: prognostic variables for recurrence and survival in surgically treated patients. 27th Annual Meeting of the European MusculoSkeletal Oncology Society, Vienna, Austria, May 21-23, 2014. 27. Varga P, Gokaslan ZL, Sciubba DM, Wolinsky J, Bettegowda C, Luzzati A, Rhines L, Fisher C, Dekutoski M, Boriani S. Mobile spine chordoma. Results of 168 patients from the AOSpine Primary Tumor Knowledge Forum. 27th Annual Meeting of the European MusculoSkeletal Oncology Society, Vienna, Austria, May 21-23, 2014. 28. Varga P, Szövérfi Z, Gokaslan Z, Fisher C, Boriani S, Dekutoski M, Chou D, Quraishi N, Fehlings M, Rhines L. Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival. 27th Annual Meeting of the European Musculo-Skeletal Oncology Society, Vienna, Austria, May 21-23, 2014. 29. Boriani S, Lo SL, Puvanesarajah V, Fisher CG, Rhines LD, Germscheid NM, Chou D, Williams RP, Bettegowda C, Gokaslan ZL. Aneurysmal bone cysts of the spine: treatment options and considerations. 27th Annual Meeting of the European Musculo-Skeletal Oncology Society, Vienna, Austria, May 21-23, 2014. Page 11 of 17

30. Varga PP, Fisher CG, Rhines LD, Gokaslan ZL, Boriani S, Lazary A, Wang W, Bozsodi A, Yip S, Bettegowda C. Prognostic significance of T gene SNP rs2305089 in individuals with spinal column chordoma. 27th Annual Meeting of the European Musculo-Skeletal Oncology Society, Vienna, Austria, May 21-23, 2014. 31. Williams R, Sowman B, Boriani S, Varga P, Luzzati A, Gokaslan Z, Fehlings M, Fisher C, Dekutoski M, Rhines L, Reynolds J, Bettegowda C, Kawahara N, Quraishi NA. Spinal osteoid osteoma: a multicentre retrospective cohort study comparison of results with appendicular osteoid osteoma. Spine Society of Australia Annual Scientific Meeting, Brisbane, Australia, April 10-12, 2014. 32. Zadnik P, Varga P, Bettegowda C, Fisher C, Fehlings M, Quraishi N, Luzzati A, Rhines L, Wolinsky JP, Sciubba D, Dekutoski M, Kawahara N, Boriani S, Gokaslan Z. Survival and recurrence following resection of chordoma in the mobile spine: results of 171 patients from the AOSpine Primary Tumor Knowledge Forum. 82nd American Association of Neurological Surgeons Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014. 33. Goldstein C, Varga P, Gokaslan Z, Boriani S, Luzzati A, Williams R, Rhines L, Fisher C, Chou D, Dekutoski M, Quraishi N, Bettegowda C, Kawahara N, Fehlings M. Hemangiomas of the spine: results of surgical management and prognostic variables for local recurrence and mortality in a multicenter study. 2014 30th Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Orlando, FL, USA, March 5-8, 2014. 34. Zadnik P, Varga P, Bettegowda C, Fisher C, Fehlings M, Quraishi N, Luzzati A, Rhines L, Wolinsky JP, Sciubba D, Dekutoski M, Kawahara N, Boriani S, Gokaslan Z. Survival and recurrence following resection of chordoma in the mobile spine: results of 171 patients from the AOSpine Primary Tumor Knowledge Forum. 2014 30th Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Orlando, FL, USA, March 58, 2014. 35. Fisher, Versteeg A, Boriani S, Varga PP, Dekutoski MB, Gokaslan ZL, Williams RP, Reynolds JJ, Fehlings MG, Bettegowda C, Kawahara N, Rhines LD. Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality in a multicenter study. Combined meeting with the Canadian Spine Society and the New Zealand Spine Society 2014, Lake Louise, AB, Canada, February 25March 1, 2014. 36. Goldstein C, Varga P, Gokaslan Z, Boriani S, Luzzati A, Williams R, Rhines L, Fisher C, Chou D, Dekutoski M, Quraishi N, Bettegowda C, Kawahara N, Fehlings M. Hemangiomas of the spine: results of surgical management and prognostic variables for local recurrence and mortality in a multicenter study. Combined meeting with the Canadian Spine Society and the New Zealand Spine Society 2014, Lake Louise, AB, Canada, February 25-March 1, 2014. 37. Fehlings M, Zamorano JJ, Nater A, Tetreault L, Varga P, Gokaslan Z, Boriani S, Fisher C, Rhines L, Bettegowda C, Kawahara N, Chou D. Risk factors for recurrence of surgically treated spine schwannomas: analysis of 169 patients from a multicenter international database. Combined meeting with the Canadian Spine Society and the New Zealand Spine Society 2014, Lake Louise, AB, Canada, February 25-March 1, 2014.

38. Fisher CG, Boriani S, Varga PP, Rhines LD, Bilsky MH, Dekutoski MB, Fehlings MG, Reynolds J, Williams R, Chou D, Quraishi NA, Bettegowda C, Gokaslan ZL, AOSpine Knowledge Forum Tumor. The new frontier for research and management of primary tumors of the spine. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30-February 1, 2014. 39. Rampersaud R. Determining optimal structural bone graft for reconstruction following en bloc resection of primary spine tumors: a synthesis of best available evidence and expert opinion. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30February 1, 2014. 40. Wu AS, Fourney D. A systematic review of aggressive and symptomatic vertebral hemangioma. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30-February 1, 2014. 41. Boriani S, Lo SL, Puvanesarajah V, Fisher CG, Varga PP, Rhines LD, Germscheid NM, Luzzati A, Chou D, Reynolds JJ, Williams RP, Zadnik P, Groves M, Sciubba DM, Bettegowda C, Gokaslan ZL, AOSpine Knowledge Forum Tumor. Aneurysmal bone cysts of the spine: treatment options and considerations. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30February 1, 2014. 42. Varga P, Macki M, Bydon M, Sciubba D, Wolinsky JP, Boriani S, Bettegowda C, Chou D, Fisher CG, Luzzati A, Reynolds JJ, Germscheid NM, Zadnik P, Rhines LD, Gokaslan ZL, AOSpine Knowledge Forum Tumor. Longterm outcomes in primary, spinal osteochondroma: a multicenter study of 27 patients. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30-February 1, 2014. 43. Varga P, Fisher C, Rhines L, Gokaslan Z, Boriani S, Lazary A, Wang WL, Germscheid N, Yip S, Bettegowda C. Prognostic significance of T gene SNP rs2305089 in individuals with spinal column chordoma. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30-February 1, 2014. 44. Clarke M. Systematic review of survival and outcomes in prostate cancer metastases to the spine. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30-February 1, 2014. 45. Sciubba D. Systematic review of survival and outcomes in breast cancer metastases to the spine. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30-February 1, 2014. 46. Fisher C. Influence of clinical and histopathologic parameters in the management of metastatic disease of the spine secondary to lung cancer – a systematic review. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30-February 1, 2014. 47. Wu AS, Fourney D. A systematic review of prognosis and treatment outcomes for metastatic renal cell carcinoma to the spine. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30-February 1, 2014. 48. Rampersaud R. Determining optimal bone graft for reconstruction following surgery for metastatic spine disease: a synthesis of best available evidence and expert Page 12 of 17

opinion. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, January 30-February 1, 2014. 49. Fisher C, Boriani S, Varga PP, Fehlings MG, Bilsky MH, Dekutoski MB, Williams RP, Berven SH, Chou D, Reynolds JJ, Quraishi NA, Rhines LD, Bettegowda C, Gokaslan ZL. A novel scientific model for rare and often neglected neoplastic conditions: AOSpine International Knowledge Forum Tumor database for primary tumors of the spine. North American Spine Society (NASS) 28th Annual Meeting, New Orleans, LA, USA, October 9-12, 2013. 50. Reynolds J, Fisher C, Boriani S, Varga PP, Fehlings MG, Bilsky MH, Dekutoski MB, Rhines L, Bettegowda C, Gokaslan Z. A novel scientific model for rare and often neglected neoplastic conditions. EuroSpine 2013, Liverpool, UK, October 2-4, 2013. 51. Fisher C, Fehlings M, Bilsky M, Dekutoski M, Luzzati A, Williams R, Berven S, Quraishi N, Rhines L, Bettegowda C, Gokaslan Z. A novel scientific model for rare and often neglected neoplastic conditions: AOSpine knowledge forum tumor international dataset for primary tumors of the spine. 20th International Meeting on Advanced Spine Techniques, Vancouver, BC, Canada, July 10-13, 2013.

55. Fisher C, Boriani S, Varga PP, Rhines LD, Kawahara N, Fourney D, Reynolds JJ, Fehlings MG, Schouten R, Gokaslan ZL. Spinal instability neoplastic score (SINS): reliability and validity among radiation oncologists. Global Spine Congress 2013, Hong Kong, April 4-6, 2013. 56. Bettegowda C. AOSpine Tumor Knowledge Forum Biobank. Fourth International Chordoma Research Workshop, Boston, MA, USA, March 21-22, 2013. 57. Fisher C, Goldschlager T, Boriani S, Varga P, Fehlings MG, Bilsky M, Dekutoski M, Luzzati A, Williams R, Berven S, Chou D, Quraishi N, Rhines L, Bettegowda C, Gokaslan Z. A novel scientific model for rare and often neglected neoplastic conditions. 11th Annual AOSpine North America Fellows Forum, Banff, AB, Canada, March 14-16, 2013. 58. Fisher C, Boriani S, Varga P, Fehlings M, Bilsky M, Dekutoski M, Luzzati A, Williams R, Berven S, Chou D, Quraishi N, Rhines L, Bettegowda C, Gokaslan Z. A novel scientific model for rare and often neglected neoplastic conditions. 13th Annual Scientific Conference of the Canadian Spine Society, Mont-Tremblant, QC, Canada, February 27-March 2, 2013.

52. Fisher C, Rhines L, Kawahara N, Fourney D, Reynolds J, Fehlings M, Schouten R, Gokaslan Z. Spinal Instability Neoplastic Score: an analysis of reliability and validity in radiation oncologists: an AOSpine knowledge forum tumor project. 20th International Meeting on Advanced Spine Techniques, Vancouver, BC, Canada, July 10-13, 2013.

59. Fisher C, Nadeau M, Varga PP, Boriani S, Rhines L, Kawahara N, Fourney D, Reynolds J, Fehlings M, Schouten R, Gokaslan Z. Spinal instability neoplastic score: an analysis of reliability and validity in radiologists: An AOSpine Knowledge Forum Tumor project. 13th Annual Scientific Conference of the Canadian Spine Society, Mont-Tremblant, QC, Canada, February 27-March 2, 2013.

53. Fisher C, Boriani S, Varga PP, Fehlings M, Bilsky M, Dekutoski M, Luzzati A, Williams R, Berven S, Chou D, Reynolds J, Quraishi N, Rhines L, Bettegowda C, Gokaslan Z. A novel evidence based model for rare and often neglected neoplastic conditions. Third Charité Spine Tumor Days, Berlin Germany, May 31-June 1, 2013.

60. Fisher C, Boriani S, Varga PP, Rhines LD, Kawahara N, Fourney D, Reynolds JJ, Fehlings MG, Schouten R, Gokaslan ZL. Spinal Instability Neoplastic Score (SINS): reliability and validity in radiation oncologists. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, February 15-16, 2013.

54. Fisher C, Boriani S, Varga PP, Rhines L, Kawahara N, Fourney D, Reynolds J, Fehlings M, Schouten R, Gokaslan Z. Assessing the reliability of Spinal Instability Neoplastic Score (SINS) among radiation oncologists and radiologists. Third Charité Spine Tumor Days, Berlin Germany, May 31-June 1, 2013.

61. Fisher C, Boriani S, Varga PP, Rhines LD, Bilsky MH, Dekutoski MB, Fehlings MG, Reynolds JJ, Williams RP, Chou D, Berven S, Quraishi NA, Bettegowda C, Gokaslan ZL. A novel model for rare and often neglected neoplastic conditions. Association for Collaborative Spine Research Meeting, San Diego, CA, USA, February 15-16, 2013.

Poster Presentations: 1.

Clarke M, Molina C, Fourney D, Fisher C, Gokaslan Z, Schmidt M, Rhines L, Fehlings M, Laufer I, Patel S, Rampersaud R, Reynolds J, Chou D, Bettegowda C, Mendel E, Weber M, Sciubba D. Systematic review of surgical treatment outcomes of prostate metastases to the spine. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.

2.

Sahgal A, Schouten R, Versteeg A, Boriani S, Varga PPal, Rhines L, Kawahara N, Fourney D, Weir L, Reynolds J, Fehlings M, Gokaslan Z, Fisher C. A multi-institutional study evaluating the reliability of the spinal instability neoplastic score (SINS) among radiation oncologists for spinal metastases. 2014 Annual Meeting of the American Society for Radiation Oncology, San Francisco, September 14-17, 2014.

3.

Dekutoski MB, Boriani S, Rose PS, Clarke MJ, Varga PP, Rhines LD, Fisher CG, Chou D, Quraishi NA, Fehlings MG, Gokaslan ZL. Enneking appropriate en bloc surgery of osteogenic sarcoma of the spine results in reduced local recurrence and enhanced survival over Enneking inappropriate intralesional surgery. Scoliosis Research Society (SRS) 49th Annual Meeting & Course, Anchorage, AK, USA, September 10-13, 2014.

4.

Varga P, Macki M, Bydon M, Sciubba DM, Wolinsky J, Boriani S, Reynolds JJ, Rhines LD, Fisher CG, Gokaslan ZL, et al. Long-term outcomes in primary spinal osteochondroma: a multicenter center study of 27 patients. 27th Annual Meeting of the European Musculo-Skeletal Oncology Society, Vienna, Austria, May 21-23, 2014.

Page 13 of 17

5.

Varga P, Fisher C, Rhines L, Gokaslan Z, Boriani S, Lazary A, Wang W-L, Germscheid N, Yip S, Bettegowda C. Prognostic significance of T gene SNP rs2305089 in individuals with spinal column chordoma. 105th American Association for Cancer Research Annual Meeting 2014, San Diego, CA, USA, April 5-9, 2014.

6.

Fisher CG, Versteeg A, Boriani S, Varga PP, Dekutoski MB, Gokaslan ZL, Williams RP, Reynolds JJ, Fehlings MG, Bettegowda C, Kawahara N, Rhines LD. Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality in a multicenter study. 82nd American Association of Neurological Surgeons Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014.

7.

8.

9.

Rhines LD, Dirks MS, Boriani S, Luzzati A, Fehlings MG, Fisher CG, Dekutoski MB, Williams R, Quraishi NA, Gokaslan ZL, Bettegowda C, Kawahara N, Varga PP. Ewing’s sarcoma of the spine: prognostic variables for recurrence and survival in surgically treated patients. 82nd American Association of Neurological Surgeons Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014. Quraishi NA, Boriani S, Varga P, Luzzati A, Gokaslan ZL, Fehlings MG, Fisher C, Dekutoski M, Rhines L, Reynolds J, Bettegowda C, Kawahara N, Williams R. A multi-center retrospective cohort study of spinal osteoid osteomas: surgical treatment and local recurrence results. 82nd American Association of Neurological Surgeons Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014. Varga PP, Macki M, Bydon M, Boriani S, Fisher CG, Rhines LD, Chou D, Luzzati A, Reynolds JJ, Kawahara N, Bettegowda C, Sciubba D, Wolinsky JP, Gokaslan ZL. Long-term outcomes in primary spinal osteochondroma: a multicenter center study of 27 patients. 82nd American Association of Neurological Surgeons Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014.

10. Zamorano JJ, Fehlings M, Nater A, Tetreault L, Varga P, Gokaslan Z, Boriani S, Fisher C, Rhines L, Bettegowda C, Kawahara N, Chou D. Local recurrence risk factors after surgical resection of spine schwannomas: analysis of 169 patients from a multicenter international database. 82nd American Association of Neurological Surgeons Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014. 11. Quraishi NA, Boriani S, Varga P, Luzzati A, Gokaslan ZL, Fehlings MG, Fisher C, Dekutoski M, Rhines L, Reynolds J, Bettegowda C, Kawahara N, Williams R. A multi-center retrospective cohort study of spinal osteoid osteomas: surgical treatment and local re-currence results .BritSpine, Warwick, U.K., April 2014. 12. Lo SL, Puvanesarajah V, Germscheid N, Chou D, Fisher C, Rhines LD, Williams RP, Boriani S, Gokaslan ZL, Bettegowda C. Aneurysmal bone cysts of the spine: treatment options and considerations (manuscript-for Mayfield Clinical Science Award). 2014 30th Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Orlando, FL, USA, March 5-8, 2014. 13. Reynolds J, Fisher C, Boriani S, Varga PP, Rhines L, Kawahara N, Fourney D, Fehlings M, Schouten R, Gokaslan Z. Spinal Instability Neoplastic Score: an analysis of reliability and validity in radiologists. EuroSpine 2013, Liverpool, UK, October 2-4, 2013. 14. Fisher C, Boriani S, Varga PP, Rhines LD, Kawahara N, Fourney D, Reynolds JJ, Fehlings MG, Schouten R, Gokaslan ZL. Spinal instability neoplastic score (SINS): reliability and validity among radiologists. Global Spine Congress 2013, Hong Kong, April 4-6, 2013. 15. Fisher C, Boriani S, Varga PP, Rhines LD, Bilsky MH, Dekutoski MB, Fehlings MG, Reynolds JJ, Williams RP, Chou D, Berven S, Quraishi NA, Bettegowda C, Gokaslan ZL. A novel model for rare and often neglected neoplastic conditions. Global Spine Congress 2013, Hong Kong, April 4-6, 2013.

Manuscripts Submitted 1.

2.

3.

Quraishi NA, Boriani S, Kumar A, Varga PP, Luzzati A, Gokaslan ZL, Fehlings MG, Fisher CG, Dekutoski MB, Rhines LD, Reynolds JJ, Germscheid NM, Bettegowda C, Williams RP, AOSpine Knowledge Forum Tumor. A multicenter cohort study of spinal osteoid osteomas: results of surgical treatment and analysis of local recurrence. The Spine Journal (In review, October 2015).

Mendel E, Weber MH, Sciubba DM. Systematic review of the outcomes of surgical treatment of prostate metastases to the spine. Global Spine Journal (Submitted, August 2015). 4.

Bettegowda C, Yip S, Lo SL, Fisher CG, Boriani S, Rhines LD, Wang JY, Lazary A, Gambarotti M, Wang W, Luzzati A, Dekutoski MB, Bilsky MH, Chou D, Fehlings MG, McCarthy EF, Quraishi NA, Reynolds JJ, Sciubba DM, Williams RP, Wolinsky JP, Zadnik PL, Germscheid NM, Kalampoki V, Varga PP, Gokaslan ZL, AOSpine Knowledge Forum Tumor. Spinal column chordoma: prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival: an ambispective cohort analysis. NeuroOncology (In review, September 2015).

Sciubba DM, Yurter A, Ju D, Gokaslan ZL, Fisher C, Rhines LD, Fehlings MG, Fourney DR, Mendel E, Laufer I, Bettegowda C, Goodwin CR, Patel SR, Rampersaud YR, Sahgal A, Reynolds JR, Chou D, Weber MH, Clarke MJ. A systematic review of clinical outcomes and prognostic factors for patients undergoing surgery for spinal metastases secondary to breast cancer. Global Spine Journal (Accepted, August 2015).

5.

Fehlings MG, Nater A, Zamorano JJ, Tetreault LA, Varga PP, Gokaslan ZL, Boriani S, Fisher CG, Rhines L, Bettegowda C, Kawahara N, Bilsky MH, Chou D. Risk factors for recurrence of surgically treated conventional spinal schwannomas: analysis of 169 patients from a multicenter international database. Spine (Accepted, August 2015).

Clarke MJ, Molina C, Fourney DR, Fisher C, Gokaslan ZL, Schmidt M, Rhines L, Fehlings MG, Laufer I, Patel SR, Rampersaud R, Reynolds JR, Chou D, Bettegowda C,

6.

Fisher GC, Versteeg AL, Dea N, Boriani S, Varga PP, Dekutoski MB, Luzzati A, Gokaslan ZL, Williams PR, Page 14 of 17

Reynolds JJ, Fehlings MG, Germscheid NM, Bettegowda C, Rhines LD. Surgical management of spinal chondrosarcomas. Spine (Accepted, July 2015). 7.

8.

Dekutoski MB, Clarke M, Rose P, Luzzati A, Rhines LD, Varga PP, Fisher CG, Chou D, Fehlings MG, Reynolds JJ, Williams R, Quraishi NA, Germscheid NM, Sciubba DM, Gokaslan ZL, Boriani S, AOSpine Knowledge Forum Tumor. Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multi-center ambispective study. Journal of Neurosurgery: Spine (In review, July 2015).

5.

Fisher CG, Versteeg A, Schouten R, Boriani S, Varga PP, Rhines LD, Heran MKS, Kawahara N, Fourney D, Reynolds JJ, Fehlings MG, Gokaslan ZL. Reliability of the Spinal Instability Neoplastic Score (SINS) among radiologists: an assessment of instability secondary to spinal metastases. American Journal of Roentgenology 203(4):869-74, 2014.

6.

Boriani S, Lo SL, Puvanesarajah V, Fisher CG, Varga PP, Rhines LD, Germscheid NM, Luzzati A, Chou D, Reynolds JJ, Williams RP, Zadnik P, Groves M, Sciubba DM, Bettegowda C, Gokaslan ZL, AOSpine Knowledge Forum Tumor. Aneurysmal bone cysts of the spine: treatment options and considerations. Journal of Neuro-Oncology 120(1):171-8, 2014.

7.

Fisher CG, Schouten R, Versteeg AL, Boriani S, Varga PP, Rhines LD, Kawahara N, Fourney D, Weir L, Reynolds JJ, Sahgal A, Fehlings MG, Gokaslan ZL. Reliability of the Spinal Instability Neoplastic Score (SINS) among radiation oncologists; an assessment of instability secondary to spinal metastases. Radiation Oncology 9(1):69, 2014.

8.

Fisher C, Goldschlager T, Boriani S, Varga PP, Fehlings MG, Bilsky MH, Dekutoski MB, Luzzati A, Williams RP, Berven S, Chou D, Reynolds JJ, Quraishi NA, Rhines LD, Bettegowda C, Gokaslan ZL. A novel model for rare and often neglected neoplastic conditions. Evidence Based Spine Journal – Spine Fellows Forum Abstract, 4(2), 2013.

Gokaslan ZL, Zadnik PL, Sciubba DM, Germscheid N, Goodwin CR, Wolinsky J-P, Bettegowda C, Groves ML, Luzzati A, Rhines LD, Fisher CG, Varga PP, Dekutoski MB, Clarke MJ, Fehlings MG, Quraishi NA, Chou D, Reynolds JJ, Williams RP, Kawahara N, Boriani S. Mobile spine chordoma: results of 166 patients from the AOSpine Knowledge Forum Tumor. Journal of Neurosurgery: Spine (Accepted, July 2015).

Published 1.

Goldstein CL, Varga PP, Gokaslan ZL, Boriani S, Luzzati A, Rhines L, Fisher CG, Chou D, Williams RP, Dekutoski MB, Quraishi NA, Bettegowda C, Kawahara N, Fehlings MG. Spinal hemangiomas: results of surgical management for local recurrence and mortality in a multicenter study. Spine 40(9):656-664, 2015.

2.

Sciubba DM, Macki M, Bydon M, Germscheid NM, Wolinsky JP, Boriani S, Bettegowda C, Chou D, Luzzati A, Reynolds JJ, Szövérfi Z, Zadnik P, Rhines LD, Gokaslan ZL, Fisher CG, Varga PP. Long-term outcomes in primary, spinal osteochondroma: a multicenter study of 27 patients. Journal of Neurosurgery: Spine 22(6):582-8, 2015.

3.

4.

Varga PP, Szövérfi Z, Fisher CG, Boriani S, Gokaslan ZL, Dekutoski MD, Chou D, Quraishi NA, Reynolds JJ, Luzzati A, Williams R, Fehlings MG, Germscheid NM, Lazary A, Rhines LD. Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival. European Spine Journal 24(5):1092-101, 2015. Fisher CG, Goldschlager T, Boriani S, Varga PP, Rhines LD, Fehlings MG, Luzzati A, Dekutoski MB, Reynolds JJ, Chou D, Berven S, Williams RP, Quraishi NA, Bettegowda C, Gokaslan ZL. An evidence based medicine model for rare and often neglected neoplastic conditions. Journal of Neurosurgery: Spine 21(5):704-10, 2014.

Book Chapters 1.

Li YM, Dirks MS, Tatsui CE, Rhines LD, Evaluation and decision making for metastatic spinal tumors, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp.1-13.

2.

Fourney DR, Fisher CG, Neoplastic Spinal Instability, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp.14-22.

3.

Lo SS, Sahgal A, Chang EL, Major complications associated with stereotactic ablative radiotherapy for spinal metastasis, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp.23-33.

4.

Laufer I, Wolinsky JP, Bilsky MH, En bloc resection in the treatment of spinal metastases: technique and indications, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp.34-44.

5.

Lina IA, Zadnik PL, Sciubba DM, Region-specific approaches, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp.45-60.

6.

Saigal R, Chou D, Spinal reconstruction and fixation/fusion, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp.61-72.

7.

Schmidt MH, Minimally invasive surgery for metastatic spine disease, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp.73-83.

8.

Mendel E, Bourekas EC, Porensky P, Vertebral augmentation for metastatic disease, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp.84-93.

Page 15 of 17

9.

Clarke MJ, Surgical complications and their avoidance, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp.94-103.

10. Boriani S, Fisher CG, Evaluation and decision making, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.1-14. 11. Fourney DR, Fisher CG, Boriani S, Safety and efficacy of surgery for primary tumors of the spine, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.15-22. 12. Kathuria S, Interventional options for primary tumors of the spine, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.23-34. 13. Kimball BY, Yamada Y, Radiation therapy for primary bone tumors, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.35-49.

Tumors. Thieme, New York, 2015, pp.134-146. 22. Varga PP, Spinopelvic reconstruction/fixation and fusion, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.147-156. 23. Rampersaud YR, Structural graft selection, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.157-164. 24. Sacks JM, Broyles JM, Wound closure techniques, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.165-174. 25. Oh MC, Deviren V, Ames CP, Complications and their avoidance: how to plan primary tumor resection to minimize complications and maximize outcome, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.175-189.

14. Okuno SH, Robinson SI, Patel S, Medical oncology principles for the spine oncology surgeon, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.50-59. 15. Nadeau M, DiPaola CP, Spinal osteoid osteoma and osteoblastoma, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.6070. 16. Boriani S, Bandiera S, Ghermandi R, Colangeli S, Amendola L, Gasbarrini A, Aneurysmal bone cyst and giant cell tumor, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.71-84. 17. Sui J, Zadnik PL, Groves ML, Gokaslan ZL, Chordoma, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.85-96. 18. Boriani S, Bandiera S, Ghermandi R, Colangeli S, Amendola L, Gasbarrini A, Chondrosarcoma, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.97-109. 19. Ju DG, Zadnik PL, Sciubba DM, Osteogenic sarcoma and Ewing's sarcoma of the spine, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.110-123. 20. Laufer I, Groves ML, Wolinsky JP, Margins in spine tumor resection: how much is enough? Is planned transgression okay?, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp.124-133. 21. Dea N, Schouten R, Principles behind determining the right approach, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL (Eds.) AOSpine Masters Series, Volume 2: Primary Spinal Page 16 of 17

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