Supplementary Table 1. Studies Excluded after Full-Text Review* Citation

Reason For Exclusion

Randomized Controlled Trials Aucamp AK, Schoeman HS, Coetzee JHJ. Pilot trial to determine the

Cross-over design

efficacy of a low dose of fish oil in the treatment of angina pectoris in the geriatric patient. Prostaglandins Leukotrienes and Essential Fatty Acids. 1993;49(3):687-9. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.

Duplicate study

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet. 1999;354(9177):447-455. Benedetto U, Melina G, di Bartolomeo R, et al. N-3 Polyunsaturated Fatty

No placebo/ not randomized

Acids after Coronary Artery Bypass Grafting. Ann Thorac Surg. 91(4): 1169-75; 2011. Blacher J, Czernichow S, Paillard F, et al. Cardiovascular effects of B-

Duplicate study

vitamins and/or N-3 fatty acids: The Su.Fol.Om3 trial. Int J Cardiol. 2012. Bobescu E, Radoi M, Dobreanu D, et al. Drugs with effects in reduction of

Abstract

oxidative stress, platelets hyperactivity, hypercoagulability status and incidence of sudden death in ACS. Fundamental and Clinical Pharmacology. 2011;25(6):I. Bonds DE, Harrington M, Worrall BB, et al. Effect of long-chain ω-3 fatty

No outcomes of interest

1   

acids and lutein+zeaxanthin supplements on cardiovascular outcomes: Results of the age-related eye disease study 2 (AREDS2) randomized clinical trial. JAMA Internal Medicine. 2014;174(5):763-771. Bozcali E, Babalik E, Himmetoglu S, Mihmanli I, Toprak S. ω-3 fatty acid

No outcomes of interest

treatment in cardiac syndrome X: A double-blind, randomized, placebocontrolled clinical study. Coronary Artery Disease. 2013;24(4):328-333. Burr ML, Fehily AM. Fatty fish and heart disease: a randomized controlled

Duplicate study

trial. World Rev Nutr Diet. 1991;66:306-12. Eussen SR, Geleijnse JM, Giltay EJ, et al. Effects of n-3 fatty acids on

No eligible outcomes

major cardiovascular events in statin users and non-users with a history of myocardial infarction. Eur Heart J. 2012;33(13):1582-8. Kurita A, Takashima H, Ando H, et al. Effects of eicosapentaenoic acid on

No eligible outcomes

peri-procedural (type IVa) myocardial infarction following elective coronary stenting. Journal of Cardiology. 2015;66(2):114-119. Leaf A, Jorgensen MB, Jacobs AK, et al. Do fish oils prevent restenosis

No eligible outcomes

after coronary angioplasty? Circulation. 1994;90(5):2248-57. Liosis S, Bauer T, Schiele R, et al. Predictors of 1-year mortality in patients

No eligible outcomes

with contemporary guideline-adherent therapy after acute myocardial infarction: results from the OMEGA study. Clinical Research in Cardiology. Sep 2013;102(9):671-677. Macchia A, Monte S, Pellegrini F, et al. Omega-3 fatty acid

No outcomes of interest

supplementation reduces one-year risk of atrial fibrillation in patients hospitalized with myocardial infarction. Eur J Clin Pharmacol.

2   

2008;64(6):627-34. Marchioli R, Barzi F, Bomba E, et al. Early protection against sudden death

Duplicate study

by n-3 polyunsaturated fatty acids after myocardial infarction: timecourse analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation. 2002;105(16):1897-1903. Matsuzaki M, Yokoyama M, Saito Y, et al. Incremental effects of

No eligible outcomes

eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease. Circ J. 2009;73(7):1283-90. Oikawa S, Yokoyama M, Origasa H, et al. Suppressive effect of EPA on the No eligible outcomes incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis. 2009;206(2):535-9. Saito Y, Yokoyama M, Origasa H, et al. Effects of EPA on coronary artery

No eligible outcomes

disease in hypercholesterolemic patients with multiple risk factors: subanalysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis. 2008;200(1):135-40. Sasaki J, Yokoyama M, Matsuzaki M, et al. Relationship between coronary

No outcomes of interest

artery disease and non-HDL-C, and effect of highly purified EPA on the risk of coronary artery disease in hypercholesterolemic patients treated with statins: sub-analysis of the Japan EPA Lipid Intervention Study (JELIS). J Atheroscler Thromb. 2012;19(2):194-204. Tuttle KR, Shuler LA, Packard DP, et al. Comparison of low-fat versus

EPA/DHA intake levels not

3   

Mediterranean-style dietary intervention after first myocardial infarction

specified

(from The Heart Institute of Spokane Diet Intervention and Evaluation Trial). Am J Cardiol. 2008;101(11):1523-30. Writing Group for the ARG, Bonds DE, Harrington M, et al. Effect of long-

Duplicate study

chain omega-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA Internal Medicine. May 2014;174(5):763-771. Prospective Cohort Studies Andrikopoulos G, Tzeis S, Nikas N, et al. Short-term outcome and

Exclude - outcomes not stratified

attainment of secondary prevention goals in patients with acute coronary by EPA+DHA intake syndrome-Results from the countrywide TARGET study. International Journal of Cardiology. 2013;168(2):922-927. Bjerregaard LJ, Joensen AM, Dethlefsen C, et al. Fish Intake and Acute

EPA/DHA intakes not specified

Coronary Syndrome. European Heart Journal. 2010;31(1):29-34. De Oliveira Otto MC, Wu JH, Baylin A, et al. Circulating Biomarkers of N-

Abstract

3 and N-6 Polyunsaturated Fatty Acid and Incidence of Cvd in the Multi-Ethnic Study of Atherosclerosis (Mesa). Circulation. 2013;127(12). Egeland GM, Meyer HE, Selmer R, et al. Cod Liver Oil Consumption,

EPA/DHA intake not specified

Smoking, and Coronary Heart Disease Mortality: Three Counties, Norway. Int J Circumpolar Health. 2001;60(2):143-9. Erkkila AT, Lehto S, Pyorala K, et al. N-3 Fatty Acids and 5-Y Risks of

EPA/DHA intake not specified

4   

Death and Cardiovascular Disease Events in Patients with Coronary Artery Disease. Am J Clin Nutr. 2003;78(1):65-71. Feskens EJ, Bowles CH, Kromhout D. Association between Fish Intake and

EPA/DHA intake not specified

Coronary Heart Disease Mortality. Differences in Normoglycemic and Glucose Intolerant Elderly Subjects. Diabetes Care. 1993;16(7):102934. Folsom AR, Demissie Z. Fish Intake, Marine Omega-3 Fatty Acids, and

No outcomes of interest

Mortality in a Cohort of Postmenopausal Women. Am J Epidemiol. 2004;160(10):1005-10. Hisamatsu T, Miura K, Ohkubo T, et al. Interaction between dietary marine- No outcomes of interest - ICD9 derived n-3 fatty acids intake and J-point elevation on the risk of cardiac

codes for cardiac death include

death: a 24-year follow-up of Japanese men. Heart. Jul

cardiovascular death

2013;99(14):1024-1029. Hoen PW, Denollet J, de Jonge P, Whooley MA. Positive affect and survival in patients with stable coronary heart disease: findings from the

Data not stratified by EPA/DHA intake

Heart and Soul Study. Journal of Clinical Psychiatry. Jul 2013;74(7):716-722. Keys A, Menotti A, Karvonen MJ, et al. The Diet and 15-Year Death Rate

EPA/DHA intake not specified

in the Seven Countries Study. Am J Epidemiol. 1986;124(6):903-15. Lentjes MAH, Welch AA, Mulligan AA, Luben RN, Wareham NJ, Khaw

Data not stratified by EPA/DHA

KT. Cod liver oil supplement consumption and health: Cross-sectional results from the EPIC-Norfolk cohort study. Nutrients. 2014;6(10):4320-4337.

5   

Leung Yinko SSL, Thanassoulis G, Stark KD, Avgil Tsadok M, Engert JC, Pilote L. Omega-3 fatty acids and the genetic risk of early onset acute

Outcomes not stratified by EPA/DHA intake

coronary syndrome. Nutrition, Metabolism and Cardiovascular Diseases. 2014;24(11):1234-1239. Nagata C, Takatsuka N, Shimizu H. Soy and Fish Oil Intake and Mortality

EPA/DHA intake not specified

in a Japanese Community. Am J Epidemiol. 2002;156(9):824-31. Poole CD, Halcox JP, Jenkins-Jones S, et al. Omega-3 Fatty acids and

No outcomes of interest

mortality outcome in patients with and without type 2 diabetes after myocardial infarction: a retrospective, matched-cohort study. Clinical Therapeutics. Jan 2013;35(1):40-51. Soinio M, Laakso M, Lehto S, et al. Dietary Fat Predicts Coronary Heart

EPA/DHA intake not specified

Disease Events in Subjects with Type 2 Diabetes. Diabetes Care. 2003;26(3):619-24. Strand E, Pedersen ER, Svingen GF, et al. Dietary intake of n-3 long-chain

Subgroup analysis of Manger

polyunsaturated fatty acids and risk of myocardial infarction in coronary 2010, no new unique data artery disease patients with or without diabetes mellitus: a prospective cohort study. BMC Medicine. 2013;11:216. Strand E, Pedersen ER, Svingen GFT, et al. Dietary intake of n-3 long-

Duplicate publication

chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: A prospective cohort study. BMC Medicine. 2013;11(1). Strom M, Halldorsson TI, Mortensen EL, et al. Fish, N-3 Fatty Acids, and

No outcomes of interest

Cardiovascular Diseases in Women of Reproductive Age: A Prospective

6   

Study in a Large National Cohort. Hypertension. 2012;59(1):36-43. Turunen AW, Verkasalo PK, Kiviranta H, et al. Mortality in a Cohort with High Fish Consumption. Int J Epi. 2008;37(5):1008-17. Vedtofte MS, Jakobsen MU, Lauritzen L, et al. Dietary Alpha-Linolenic

EPA/DHA intake not examined in relation to CHD outcomes No outcomes if interest

Acid, Linoleic Acid, and N-3 Long-Chain Pufa and Risk of Ischemic Heart Disease. Am J Clin Nutr. 2011;94(4):1097-103. Vedtofte MS, Jakobsen MU, Lauritzen L, et al. Association between the intake of alpha-linolenic acid and the risk of CHD. British Journal of

Data not stratified by EPA/DHA intake

Nutrition. Sep 14 2014;112(5):735-743. Wu JH, Lemaitre RN, King IB, et al. Circulating omega-6 polyunsaturated

EPA/DHA intake not specified

fatty acids and total and cause-specific mortality: the Cardiovascular Health Study. Circulation. Oct 7 2014;130(15):1245-1253. Yamagishi K, Iso H, Date C, et al. Fish, Omega-3 Polyunsaturated Fatty Acids, and Mortality from Cardiovascular Diseases in a Nationwide

EPA/DHA intake not specified (sent author email to confirm)

Community-Based Cohort of Japanese Men and Women the Jacc (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study. J Am Coll Cardiol. 2008;52(12):988-96. *Multiple reasons for publication exclusion may exist, only one reason listed here.

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