Product Guide

2014-2015

Sold Exclusively Through Veterinarians and Other Qualified Veterinary Professionals

Dear Veterinary Professional, For more than 80 years, Standard Process has been committed to developing nutritional supplements that help improve and enhance quality of life for people. Using the principles of our founder, Dr. Royal Lee, we also deliver supplements specifically designed for animals with Standard Process Veterinary Formulas. In the 1920s, Dr. Lee focused on developing whole food supplements for humans because he saw an immediate need for a more natural approach to health care. Realizing the benefits of whole food supplements, veterinarians began to use Standard Process’ human products for their patients. With the increasing interest in whole food supplements for animals, our customer profile grew over the years to include many veterinarians. While the Standard Process human products helped animals live better lives for many years, we realized that there were differences between animal and human nutritional requirements that needed to be addressed. This prompted us to develop a supplement line specifically designed for animals. As with all our products, the Standard Process commitment to quality remains constant. We control the quality of our products from the time seeds are planted on our certified organic farmland until the final product is produced and distributed from our state-of-art manufacturing facility. In doing so, we continuously produce highquality nutritional supplements made with whole food and other ingredients that improve our health and lives, as well as those of our dogs, cats, and horses. Standard Process is committed to you, the veterinary professional, just as you have dedicated your life to helping animals. We have always believed that the best health care comes from trained professionals. We continue to stand by this principle by only selling Standard Process Veterinary Formulas through veterinarians and other qualified veterinary professionals. We hope your patients enjoy the health benefits that Standard Process Veterinary Formulas provide. Yours in health, The DuBois Family

Charles C. DuBois President

Mary DuBois-Wisniewski Vice President | Administration

Our Mission Standard Process is devoted to improving the quality of life by providing safe, effective, high-quality dietary supplements through health care professionals.

Our Corporate Values Standard Process demonstrates commitment to the Whole: Person

By fostering the physical, emotional, intellectual, and spiritual health of customers and employees.

Product By emphasizing the importance of concentrated whole foods and herbs in the product line. Process By ensuring the highest quality in every stage of development, from farming through shipping. Planet By utilizing environmentally safe farming, manufacturing, and business practices. Posterity By preserving and strengthening the company for all future generations.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Index

Index What Makes Our Veterinary Formulas Unique . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Canine Formulas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Canine Adrenal Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Canine Cardiac Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Canine Dermal Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Canine Enteric Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Canine Flex Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Canine Hepatic Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Canine Immune System Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Canine Musculoskeletal Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Canine Renal Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Canine Thyroid Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Canine Whole Body Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Feline Formulas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Feline Cardiac Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Feline Enteric Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Feline Hepatic Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Feline Immune System Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 Feline Renal Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Feline Whole Body Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 Equine Formulas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Equine GI Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 Equine Immune Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 Equine Metabolic Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Equine Mobility Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 Equine Performance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 About Standard Process . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 Reading Labels and the “Best Used By” Code . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 References and Glossary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 Getting Started . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50

This guide is for veterinary professional use only. Clients should consult with a veterinary professional before feeding any products to animals. 2

Our Veterinary Formulas

What Makes Our Veterinary Formulas Unique Whole Foods and the Whole Food Philosophy Since 1929, Standard Process has been dedicated to the field of nutritional supplements and the whole food philosophy, introduced by our founder, Dr. Royal Lee. Dr. Lee’s goal was to provide nutrients as they are found in nature—in a whole food state where he believed their natural potency and efficacy would be realized. Dr. Lee believed that when nutrients remain intact and are not split from their natural associated synergists, known and unknown, bioactivity is markedly enhanced over isolated nutrients. Following this philosophy, small amounts of whole food concentrates will offer enhanced nutritional support compared to an isolated or fractionated vitamin. Standard Process products are built upon this holistic philosophy.

The Key Is High-Quality Ingredients As in any recipe, the quality of ingredients affects the quality of the final product. Manufacturers who grow their own ingredients have absolute control over them, so Standard Process owns a certified organic farm. But for items we can’t grow, Standard Process has an extensive, rigorous system of supplier auditing and validation. This allows us to provide patients with a product that has been controlled, tested, and verified from beginning to end.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Our Veterinary Formulas

Take a Look at What’s Inside Whole Foods—complete foods that are minimally processed If you read our product labels, you will find many recognizable foods. Some of these whole food ingredients are grown locally on our certified organic farm, including alfalfa, barley grass, beets, Brussels sprouts, buckwheat, kale, kidney beans, oats, pea vine, Spanish black radish, and sweet potatoes. This allows us to control the quality of our ingredients from seed to supplement.

Whole Food Extracts—processed part of a whole food containing two or more constituents of the original whole food These extracts are used when a beneficial concentration of nutrients cannot be obtained using a whole food. Chlorophyll extract is an example; it is derived from plant material and acts as a stimulant for tissue health, maintenance, and regeneration.

Animal Tissue Extracts and Concentrates—health-supporting whole food ingredients derived from bovine, ovine, and porcine sources These tissues provide many essential nutritional compounds. It is the known and unknown substances contained in the tissues that we believe provide nutrients and support for the corresponding tissues in the patient. All raw animal tissues are obtained exclusively from U.S. Department of Agriculture (USDA)-inspected facilities. Protomorphogen™ Brand Extracts Continuing the pioneering work of Dr. Royal Lee, certain Standard Process products contain specific Protomorphogen™ brand extracts. Protomorphogen™ brand extracts provide an important adjunct for nutritional support of cellular function. In the 1940s, Dr. Royal Lee pioneered a unique method of deriving extracts that contain what he called cell determinants from specific organs and glands for clinical use. Dr. Lee believed that these cell determinants functioned in cell regulation, maintenance, and interaction with tissue antibodies. It is important to note that Protomorphogen™ extracts differ in manufacture from what are commonly referred to as glandulars. Because our extracts are manufactured with an exclusive proprietary process, they should not be confused with the more common ingredient known as a “glandular.”

“The Best Sources of Vitamins and Minerals Are Found in Whole Foods.” —Dr. Royal Lee

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Our Veterinary Formulas

Cytosol™ Brand Extracts Cytosol™ brand extracts are derived from the cytoplasm of selected organs and glands. These extracts contain cellular factors such as hormone precursors and synergistic cofactors that are the biochemical building blocks essential to cellular metabolism. ProtomorphogenTM and CytosolTM extracts offer complementary support to organs and glands. Whole Desiccates Whole desiccates are whole tissues that have been dried to provide the nutritional content of the organ in a concentrated form.

Botanicals—plant compounds with health-supporting properties Botanicals provide important factors that contribute additional support to the body’s systems by complementing the vitamins, minerals, enzymes, and tissue concentrates found in foods.

Whole Food Isolates—single components from a whole food Sometimes levels of specific nutrients are not available in sufficient quantities in foods to address certain health challenges. In this case, we use evidence-based food isolates to complement whole food ingredients and provide optimal nutritional support. Isolates like glucosamine are used in our products because they are well researched and have strong evidence for efficacy. Isolates derived from whole food sources are combined with other whole food ingredients to maximize their efficacy.

Synthetic Ingredients—a nutrient produced by chemical means We believe Dr. Lee included synthetics in his original formulas to meet label claims and/or enhance product effect. Historically, and still today, this type of ingredient is used selectively. Where synthetics appear, they’ve been added to protect the complexity and synergistic design of the formula.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Canine Formulas Canine Formulas Since dogs are omnivores, the canine formulas contain a variety of ingredients, including a balance of animal tissues and botanical materials. These ingredient combinations provide a spectrum of nutrients to support multiple organs. Most of the canine formulas are powdered to accommodate the range of body weights in the canine population. 6

The adrenal glands help the body adapt to stress through the release of corticosteroids and hormones. With chronic stress, the adrenals can become fatigued, affecting many body systems, including the pituitary and thyroid glands, autonomic nervous system, liver, duodenum, and kidneys. Canine Adrenal Support is formulated to: ▶▶Help adrenal glands respond normally to stress and metabolic demands ▶▶Support the glands’ ability to rebuild and regenerate ▶▶Provide vital nutritional support to related organs

Indications for Use ▶▶Sudden stressful event or ongoing stress (internal or external) ▶▶Signs of fatigue, reduced stamina, glucose intolerance, inflammatory response, and inadequate immune system functioning ▶▶Clinical signs associated with adrenal stress as indicated by alkaline phosphatase, ACTH stimulation test, low-dose dexamethasone suppression test, and/or high-dose dexamethasone suppression test

Adjunctive Products ▶▶Canine Whole Body Support

Canine Formulas

Canine Adrenal Support

Supplement Facts Stated amounts depend on dose. Ingredients Bovine liver, bovine adrenal PMG™ extract, black currant juice, alfalfa juice, porcine duodenum, Eleutherococcus senticosus, defatted wheat germ, mushroom, nutritional yeast, carrot, wheat germ oil, veal bone PMG™ extract, buckwheat leaf juice and seed, bovine adrenal Cytosol™ extract, pea vine juice, rice bran, bovine adrenal, bovine kidney, sea salt, oat flour, bovine orchic extract, allantoin, bovine pituitary PMG™extract, bovine thyroid PMG™ extract, soybean lecithin, chlorophyll extract, kelp, and manganese glycerophosphate. Minerals Sodium. . . . . . 35 mg / ½ tsp. Content Product No. Servings per Container 25 g . . . . . . . . A1100 . . . . . . . . . 65 based on 1⁄8 tsp. 100 g. . . . . . . A1150 . . . . . . . . . 65 based on ½ tsp.

▶▶Canine Hepatic Support

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please consult the product packaging label for the most accurate product information.

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Canine Formulas

Canine Cardiac Support The heart is at the center of the cardiovascular system, which is a complex, coordinated group of organs and tissues. Nutritional support for the cardiovascular system also includes the other organs that support the heart such as the liver, kidneys, and digestive system. Canine Cardiac Support provides nutrients that: ▶▶Support optimal cardiac function ▶▶Support natural muscle-cell healing and regeneration

Indications for Use ▶▶General cardiac support ▶▶Patients with increased cardiac demand or conditions that increase cardiac workload as indicated by cardiac auscultation, EKG, thoracic radiographs, and echocardiography

Adjunctive Products ▶▶Canine Renal Support ▶▶Canine Adrenal Support

Supplement Facts Stated amounts depend on dose. Ingredients L-carnitine, bovine liver, bovine heart PMG™ extract, rice bran, bovine kidney, bovine and ovine spleen, bovine orchic extract, beet root, defatted wheat germ, buckwheat leaf juice and seed, high selenium yeast, ribonucleic acid, wheat germ oil, bovine pancreas Cytosol™ extract, veal bone PMG™ extract, alfalfa juice, mushroom, calcium lactate, Crataegus oxyacantha, nutritional yeast, carrot, pea vine juice, Tillandsia usneoides, para‑aminobenzoate, chlorophyll extract, inositol, choline bitartrate, oat flour, and porcine brain. Minerals Calcium. . . . . . 1 mg / ½ tsp. Sodium. . . . . . 12 mg / ½ tsp.

Selenium. . . . . 18 mcg / ½ tsp.

Content Product No. Servings per Container 25 g . . . . . . . . A1200 . . . . . . . . . 60 based on 1⁄8 tsp. 100 g. . . . . . . A1250 . . . . . . . . . 70 based on ½ tsp.

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

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41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

Please consult the product packaging label for the most accurate product information.

Nutrition plays a major role in skin health. Healthy skin is a result of a well-functioning, synchronized effort by tissues and organs in the body. Canine Dermal Support contains whole food ingredients to help: ▶▶Maintain proper liver, adrenal, immune, and intestinal function ▶▶Support and maintain the skin’s ability to withstand the effects of environmental exposure to toxins, antigens, and microorganisms

Indications for Use ▶▶General skin health ▶▶General digestive system health, adrenal gland health, or immune system health

Adjunctive Products ▶▶Canine Enteric Support ▶▶Canine Adrenal Support ▶▶Canine Hepatic Support

Supplement Facts

Canine Formulas

Canine Dermal Support

Stated amounts depend on dose. Ingredients Bovine liver, L-glutamine, Silybum marianum, bovine kidney, defatted wheat germ, alfalfa juice, Emblica officinalis, carrot (root), fat soluble extract (from alfalfa [whole plant], sunflower [seed], carrot [root], Tillandsia usneoides, buckwheat [leaf and seed], and pea [vine]), bovine and ovine spleen, bovine adrenal PMG™ extract, Strombus gigas, calcium lactate, bovine liver fat extract, black currant juice, Carthamus tinctorius, bovine liver PMG™ extract, nutritional yeast, mushroom, porcine jejunum, maltodextrin, porcine stomach, betaine hydrochloride, bovine parotid PMG™ extract, para-aminobenzoate, beet leaf juice, beet root, oat flour, porcine brain, bovine adrenal Cytosol™ extract, purified bovine bile salts, bone meal, Taraxacum officinale, and inositol. Minerals Zinc . . . . . . . . 56 mcg / ½ tsp. Vitamins Vitamin A. . . . . 12 IU / ½ tsp. Content Product No. Servings per Container 30 g . . . . . . . . A1300 . . . . . . . . . 65 based on 1⁄8 tsp. 125 g. . . . . . . A1350 . . . . . . . . . 75 based on ½ tsp.

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please consult the product packaging label for the most accurate product information.

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Canine Formulas

Canine Enteric Support A healthy digestive tract is critical to overall health and well-being. In addition to breakdown and absorption of nutrients, digestive health can also have a significant impact on other body systems (immune system, liver, bone marrow, or adrenal glands). Canine Enteric Support contains a variety of functional foods, both plant and animal, that “feed” the various components of the digestive system to: ▶▶Provide general digestive system support ▶▶Support the ability of intestinal cells to function, regenerate, and respond to daily metabolic and immune challenges

Indications for Use ▶▶General enteric support ▶▶Patients with increased metabolic demand ▶▶Hepatic patients in need of additional enteric support as indicated by ALT, alkaline phosphatase, bile acids studies, and enteric histopathology

Adjunctive Products ▶▶Canine Immune System Support ▶▶Canine Hepatic Support

Supplement Facts Stated amounts depend on dose. Ingredients Porcine stomach, L-glutamine, porcine duodenum, porcine jejunum, bovine and ovine spleen, defatted wheat germ, bovine liver, veal bone PMG™ extract, alfalfa juice, bovine parotid PMG™ extract, bovine kidney, mushroom, nutritional yeast, bovine liver PMG™ extract, bovine adrenal PMG™ extract, pea vine juice, bovine pancreas Cytosol™ extract, carrot, rice bran, bovine orchic extract, oat flour, bovine pancreas PMG™ extract, purified bovine bile salts, Tillandsia usneoides, licorice, allantoin, wheat germ oil, beet leaf juice, beet root, calcium glycerophosphate, chlorophyll extract, bovine pituitary PMG™ extract, bentonite, and bovine parathyroid. Minerals Phosphorus. . . 5 mg / ½ tsp.

Sodium. . . . . . 12 mg / ½ tsp.

Vitamins Vitamin B2. . . . 30 mcg / ½ tsp.

Niacin. . . . . . . 0.2 mcg / ½ tsp.

Content Product No. Servings per Container 30 g . . . . . . . . A1400 . . . . . . . . . 75 based on 1⁄8 tsp. 110 g. . . . . . . A1450 . . . . . . . . . 70 based on ½ tsp.

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

10

41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

Please consult the product packaging label for the most accurate product information.

Wear and tear of joints and surrounding tissues, especially in very active and aging dogs, can cause stiffness and trigger inflammatory responses. Canine Flex Support encourages the normal repair and rebuilding of cartilage and provides targeted joint protection. It provides nutrients that: ▶▶Moderate the body’s normal inflammatory response ▶▶Provide potent antioxidants ▶▶Support healthy immune modulation

Indications for Use ▶▶Prevention: especially for large breeds, performance dogs, and growing puppies ▶▶Short- or long-term support: for any dog with joint challenges, especially for active or aging dogs

Adjunctive Products ▶▶Canine Musculoskeletal Support ▶▶Tuna Omega-3 Oil (formulated for human use, read label for contents)

Canine Formulas

Canine Flex Support

Supplement Facts Stated amounts depend on dose. Ingredients Glucosamine (as glucosamine sulfate) (shellfish source) . . . . . 250 mg Chondroitin (as chondroitin sulfate) (bovine source). . . . . . . . . 110 mg Vitamin E (as mixed tocopherols) (soy). . . . . . . . . . . . . . . . . . 5 IU Vitamin C (as ascorbic acid) . . . . . . . . . . . . . . . . . . . . . . . . . 5 mg Other Ingredients Honey, ginger root, bovine liver, maltodextrin, gum acacia, turmeric extract, and calcium stearate. Content Product No. Servings per Container 100 wafers . . . A1480 . . . . . . . . . 100 based on 1 wafer per serving

Dose Schedule Based on body weight, the canine patient should receive the canine formula according to the following recommendations, or as otherwise directed. 1-25 lbs.. . . . . 1 wafer / day 26-50 lbs.. . . . 2 wafers / day

51-80 lbs.. . . . 3 wafers / day > 80 lbs.. . . . . 4 wafers / day

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please consult the product packaging label for the most accurate product information.

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Canine Formulas

Canine Hepatic Support The liver is a complex organ that interacts with most organs in the body, including the intestinal tract, cardiovascular system, kidneys, and autonomic nervous system. Nutritional support for the liver must address these interactions to be effective. Canine Hepatic Support is formulated to support: ▶▶Liver metabolism

▶▶Bile production and flow

▶▶Hepatic circulation

▶▶Hepatic immune function

Indications for Use ▶▶General hepatic support ▶▶Patients with increased metabolic demand ▶▶Patients in need of additional hepatic support as indicated by ALT, alkaline phosphatase, bile acids studies, BUN, liver histopathology, or ultrasound

Adjunctive Products ▶▶Canine Renal Support ▶▶Canine Enteric Support

Supplement Facts Stated amounts depend on dose. Ingredients Bovine liver PMG™ extract, bovine and ovine spleen, porcine duodenum, bovine kidney, porcine stomach, veal bone PMG™ extract, porcine jejunum, wheat germ oil, mushroom, bovine liver, bovine heart PMG™ extract, bovine orchic extract, ribonucleic acid, alfalfa juice, defatted wheat germ, calcium lactate, Ginkgo biloba, nutritional yeast, rice bran, black currant seed oil, beet leaf juice, beet root, oat flour, Silybum marianum, Taraxacum officinale, bovine liver fat extract, buckwheat leaf juice and seed, high selenium yeast, calcium glycerophosphate, L-glutamine, zinc liver chelate, Brussels sprouts, para-aminobenzoate, Strombus gigas, carrot, Tillandsia usneoides, bovine pituitary PMG™ extract, porcine brain, allantoin, bovine thyroid PMG™ extract, magnesium lactate, betaine hydrochloride, inositol, chlorophyll extract, and choline bitartrate. Minerals Calcium. . . . . . 2.5 mg / ½ tsp.

Magnesium . . . 800 mcg / ½ tsp.

Content Product No. Servings per Container 30 g . . . . . . . . A1500 . . . . . . . . . 70 based on 1⁄8 tsp. 110 g. . . . . . . A1550 . . . . . . . . . 75 based on ½ tsp.

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

12

41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

Please consult the product packaging label for the most accurate product information.

The immune system is a complex array of cells that are found throughout the body. Immune cells are designed to work in conjunction with other immune cells to provide a defense against unwanted invaders. The complexity of the immune system requires a multidimensional approach of nutritional factors. The nutritional support of the immune system is directed at facilitating normal function and is not intended to be suppressive or stimulating. Canine Immune System Support: ▶▶Provides nutritional and biochemical support for healthy immune cells and tissues ▶▶Supports optimal immune protection

Indications for Use ▶▶General immune system support ▶▶Colder climates or during the fall/winter months ▶▶When kenneled or in a shelter

Adjunctive Products ▶▶Canine Hepatic Support ▶▶Canine Enteric Support

Canine Formulas

Canine Immune System Support

Supplement Facts Stated amounts depend on dose. Ingredients Bovine liver, nutritional yeast, bovine and ovine spleen, rice bran, bovine spleen PMG™ extract, bovine thymus PMG™ extract, carrot, bovine kidney, bovine thymus Cytosol™ extract, buckwheat leaf juice and seed, bovine pancreas Cytosol™ extract, pea vine juice, Eleutherococcus senticosus, porcine duodenum, black currant juice, porcine jejunum, bovine adrenal Cytosol™ extract, veal bone PMG™ extract, oat flour, calcium lactate, purified bovine bile salts, defatted wheat germ, mushroom, Spanish black radish, ribonucleic acid, bovine adrenal PMG™ extract, Tillandsia usneoides, Withania somnifera, zinc liver chelate, kelp, and black currant seed oil. Minerals Calcium. . . . . . 2.5 mg / ½ tsp. Sodium. . . . . . 25 mg / ½ tsp.

Magnesium. . . 700 mcg / ½ tsp. Zinc . . . . . . . . 480 mcg / ½ tsp.

Content Product No. Servings per Container 30 g . . . . . . . . A1600 . . . . . . . . . 75 based on 1⁄8 tsp. 110 g. . . . . . . A1650 . . . . . . . . . 75 based on ½ tsp.

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please consult the product packaging label for the most accurate product information.

13

Canine Formulas

Canine Musculoskeletal Support The canine musculoskeletal system has many components: bones, joints, muscles, tendons, ligaments, nerves, blood vessels, and organs that support these tissues, including the liver, kidneys, and adrenal glands. Canine Musculoskeletal Support: ▶▶Provides a wide range of essential nutrients ▶▶Helps maintain optimal health and function ▶▶Helps tissues respond to extra demands by promoting regeneration

Indications for Use ▶▶General growth support ▶▶Performance/working animals ▶▶Senior animals ▶▶General musculoskeletal support ▶▶Neuromuscular disorders

Adjunctive Products ▶▶Canine Hepatic Support ▶▶Canine Whole Body Support

Supplement Facts Stated amounts depend on dose. Ingredients Veal bone PMG™ extract, Boswellia serrata, bovine trachea, bovine heart PMG™ extract, Perna canaliculus, pea vine juice, oat flour, black currant juice, carrot, bovine liver, bovine adrenal, Eleutherococcus senticosus, bovine orchic Cytosol™ extract, bovine kidney, soybean lecithin, bromelain, alfalfa juice, porcine jejunum, Strombus gigas, porcine duodenum, beet root, manganese lactate, ribonucleic acid, bovine thyroid PMG™ extract, buckwheat leaf juice and seed, calcium lactate, beet root juice, defatted wheat germ, wheat germ oil, Tillandsia usneoides, beet leaf juice, mushroom, dicalcium phosphate, magnesium lactate, calcium glycerophosphate, chlorophyll extract, and extract of Rhizopus oryzae grown on Tillandsia usneoides and beet root. Minerals Sodium. . . . . . 17 mg / ½ tsp. Magnesium. . . 900 mcg / ½ tsp.

Manganese. . . 700 mcg / ½ tsp.

Content Product No. Servings per Container 20 g . . . . . . . . A1700 . . . . . . . . . 65 based on 1⁄8 tsp. 90 g . . . . . . . . A1750 . . . . . . . . . 78 based on ½ tsp.

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

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41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

Please consult the product packaging label for the most accurate product information.

For renal challenges, not only should the kidneys be supported but consideration should also be given to support of the liver, cardiovascular system, and autonomic nervous system. Canine Renal Support: ▶▶Provides support for the natural rehabilitation of the kidneys ▶▶Supports the liver, cardiovascular system, and autonomic nervous system

Indications for Use ▶▶Patients in need of renal support as indicated by BUN, creatinine, phosphorus, urine specific gravity ▶▶Hepatic patients in need of additional renal support

Adjunctive Products ▶▶Canine Hepatic Support ▶▶Canine Cardiac Support

Supplement Facts Stated amounts depend on dose.

Canine Formulas

Canine Renal Support

Ingredients Bovine kidney, kidney bean extract, buckwheat leaf juice and seed, oat flour, bovine liver, ribonucleic acid, nutritional yeast, veal bone PMG™ extract, bovine orchic Cytosol™ extract, pea vine juice, beet root, bovine and ovine spleen, alfalfa juice, bovine kidney PMG™ extract, mushroom, rice bran, bovine thyroid PMG™ extract, carrot, wheat germ oil, black currant seed oil, black currant juice, kelp, bovine adrenal, allantoin, bovine pituitary PMG™ extract, chlorophyll extract, manganese glycerophosphate, beet leaf juice, and extract of Rhizopus oryzae grown on Tillandsia usneoides and beet root. Minerals Sodium. . . . . . 60 mg / ½ tsp.

Chloride. . . . . 10 mg / ½ tsp.

Content Product No. Servings per Container 30 g . . . . . . . . A1800 . . . . . . . . . 70 based on 1⁄8 tsp. 110 g. . . . . . . A1850 . . . . . . . . . 75 based on ½ tsp.

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please consult the product packaging label for the most accurate product information.

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Canine Formulas

Canine Thyroid Support The endocrine system has an interesting web of interactions with different organs in the body, and the thyroid gland plays a major role. Canine Thyroid Support: ▶▶Provides critical trace nutrient support for the thyroid gland ▶▶Supports glands and tissues that interact with the thyroid, including the adrenals and liver ▶▶Supports all aspects of thyroid function

Indications for Use ▶▶General thyroid support ▶▶Patients in need of thyroid support as indicated by T3, T4, TSH, and other testing parameters ▶▶Patients with increased metabolic demand

Adjunctive Products ▶▶Canine Whole Body Support ▶▶Canine Hepatic Support

Supplement Facts Stated amounts depend on dose. Ingredients Eleutherococcus senticosus, bovine liver, bovine orchic extract, bovine adrenal, bovine thyroid PMG™ extract (processed to remove its thyroxine), Tillandsia usneoides, mushroom, buckwheat leaf juice and seed, calcium lactate, Strombus gigas, carrot, bovine adrenal PMG™ extract, soybean lecithin, porcine ovary PMG™ extract, kelp, wheat germ oil, rice bran, bone meal, pea vine juice, defatted wheat germ, alfalfa juice, bovine heart PMG™ extract, porcine duodenum, para-aminobenzoate, oat flour, ribonucleic acid, porcine brain, calcium glycerophosphate, and ascorbic acid. Minerals Calcium. . . . . . 8 mg / ½ tsp. Phosphorus. . . 5 mg / ½ tsp.

Sodium. . . . . . 25 mg / ½ tsp.

Content Product No. Servings per Container 25 g . . . . . . . . A1900 . . . . . . . . . 65 based on 1⁄8 tsp. 100 g. . . . . . . A1950 . . . . . . . . . 80 based on ½ tsp.

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

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41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

Please consult the product packaging label for the most accurate product information.

Many dogs have a diet limited to highly processed pet foods. Supplements made from whole foods, organ and tissue extracts, botanicals, and other ingredients can fill the nutrition gap created by feeding processed foods. Canine Whole Body Support: ▶▶Provides general multisystem support for daily maintenance of all body systems, with emphasis on a healthy endocrine system ▶▶Is an excellent nutritional foundation for use with all other system-support formulas

Indications for Use ▶▶Daily supplement for any patient ▶▶Growing animals ▶▶Performance/working animals ▶▶Endocrine system support ▶▶Pregnancy/lactation ▶▶Senior animals

Adjunctive Products ▶▶Canine Hepatic Support ▶▶Canine Immune System Support ▶▶Canine Renal Support ▶▶Canine Cardiac Support

Supplement Facts

Canine Formulas

Canine Whole Body Support

Stated amounts depend on dose. Ingredients Defatted wheat germ, bovine liver, pea vine juice, nutritional yeast, carrot, rice bran, bovine and ovine spleen, alfalfa juice, Silybum marianum, beet root, porcine stomach, oat flour, bovine heart PMG™ extract, Tillandsia usneoides, L-carnitine, Brussels sprouts, bovine orchic Cytosol™ extract, kidney bean extract, kelp, bovine liver PMG™ extract, bone meal, bovine trachea, bovine kidney PMG™ extract, mushroom, bovine kidney, inositol, choline bitartrate, thiamine hydrochloride, bovine adrenal Cytosol™ extract, celery, bentonite, veal bone PMG™ extract, bovine liver fat extract, calcium lactate, manganese glycerophosphate, carbamide, bovine adrenal PMG™ extract, bovine hypothalamus Cytosol™ extract, bovine thymus PMG™ extract, bovine pituitary PMG™ extract, zinc liver chelate, copper liver chelate, iron liver chelate, soybean lecithin, bovine hypothalamus PMG™ extract, bovine thymus Cytosol™ extract, bovine thyroid PMG™ extract, para-aminobenzoate, porcine brain, and ascorbic acid. Minerals Calcium. . . . . . 5 mg / ½ tsp. Sodium. . . . . . 14 mg / ½ tsp. Iron . . . . . . . . 500 mcg / ½ tsp.

Copper. . . . . . . 200 mcg / ½ tsp. Manganese. . . . 600 mcg / ½ tsp. Zinc . . . . . . . . 300 mcg / ½ tsp.

Content Product No. Servings per Container 25 g . . . . . . . . A2000 . . . . . . . . . 65 based on 1⁄8 tsp. 100 g. . . . . . . A2050 . . . . . . . . . 70 based on ½ tsp.

Dose Schedule Based on body weight, the canine patient should receive the formula according to the following recommendations, or as otherwise directed. 1-10 lbs.. . . . . 1⁄8 tsp. once / day 11-20 lbs.. . . . 1⁄8 tsp. twice / day 21-40 lbs.. . . . ¼ tsp. twice / day

41-60 lbs.. . . . ½ tsp. twice / day 61-80 lbs.. . . . ¾ tsp. twice / day > 80 lbs.. . . . . 1 tsp. twice / day

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please consult the product packaging label for the most accurate product information.

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Feline Formulas Feline Formulas Since cats are obligate carnivores, the feline formulas contain fewer ingredients than the canine formulas and focus more on animal tissues. These ingredient combinations provide a wide range of nutrients to support multiple organs. The feline formulas are in tablet form to allow for several administration options.

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The heart is at the center of the cardiovascular system, which is a complex, coordinated group of organs and tissues. Nutritional support to the cardiovascular system also includes the organs that support the heart, such as the liver, kidneys, and digestive system. Feline Cardiac Support: ▶▶Provides nutrients that support optimal cardiac function ▶▶Supports natural muscle-cell healing and regeneration

Indications for Use ▶▶General cardiac support ▶▶Patients with increased cardiac demand or conditions that increase cardiac workload as indicated by cardiac auscultation, EKG, thoracic radiographs, and echocardiographs

Adjunctive Products ▶▶Feline Renal Support ▶▶Feline Hepatic Support ▶▶Feline Whole Body Support

Feline Formulas

Feline Cardiac Support

Supplement Facts Stated amounts depend on dose. Ingredients Bovine orchic Cytosol™ extract, bovine adrenal, bovine heart PMG™ extract, bovine liver, Tillandsia usneoides, alfalfa juice, bovine and ovine spleen, L-carnitine, bovine heart Cytosol™ extract, buckwheat leaf juice and seed, bovine kidney, Emblica officinalis, rice bran, pea vine juice, nutritional yeast, Crataegus oxyacantha, ribonucleic acid, kelp, bovine adrenal Cytosol™ extract, wheat germ oil, oat flour, and bone meal. Other Ingredients Honey and calcium stearate as tableting aids. Minerals Calcium. . . . . . 1 mg / tablet Potassium. . . . 5 mg / tablet

Sodium. . . . . . 3 mg / tablet Manganese. . . 3.5 mcg / tablet

Content Product No. 60 tablets . . . . A5000

How to Administer The feline patient should receive one tablet two times per day, or as directed. Feline formulas can be administered in a variety of ways, including: ▶▶ Whole tablet or crushed ▶▶ Dosed directly or mixed with food ▶▶ Cautiously, as a powder suspended in water given by oral syringe To familiarize the cat with the supplement, it may be helpful to place one tablet beside the food bowl for two or three days prior to mixing the tablet with the food.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please consult the product packaging label for the most accurate product information.

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Feline Formulas

Feline Enteric Support A healthy digestive tract is critical to overall health and well-being. The digestive health of an animal can impact not only breakdown and absorption of nutrients, but can also have a significant impact on other body systems (immune system, liver, bone marrow, or adrenal glands). Feline Enteric Support contains a variety of functional foods, both plant and animal, that “feed” the various components of the digestive system to: ▶▶Provide general digestive system support ▶▶Support the ability of intestinal cells to function, regenerate, and respond to daily metabolic and immune challenges

Indications for Use ▶▶General enteric support ▶▶Patients with increased metabolic demand ▶▶Hepatic patients in need of additional enteric support as indicated by ALT, alkaline phosphatase, bile acids studies, and enteric histopathology

Adjunctive Products ▶▶Feline Immune System Support ▶▶Feline Hepatic Support ▶▶Feline Whole Body Support

Supplement Facts Stated amounts depend on dose. Ingredients Bovine and ovine spleen, porcine jejunum, bovine liver, porcine stomach, L-glutamine, porcine duodenum, rice bran, nutritional yeast, bovine kidney, defatted wheat germ, alfalfa juice, Strombus gigas, carrot, allantoin, veal bone PMG™ extract, and chlorophyll extract. Other Ingredients Honey and calcium stearate as tableting aids. Minerals Manganese. . . 3.5 mcg / tablet Content Product No. 60 tablets . . . . A5100

How to Administer The feline patient should receive one tablet two times per day, or as directed. Feline formulas can be administered in a variety of ways, including: ▶▶ Whole tablet or crushed ▶▶ Dosed directly or mixed with food ▶▶ Cautiously, as a powder suspended in water given by oral syringe To familiarize the cat with the supplement, it may be helpful to place one tablet beside the food bowl for two or three days prior to mixing the tablet with the food.

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Please consult the product packaging label for the most accurate product information.

The liver is a complex organ that interacts with most organs in the body, including the intestinal tract, cardiovascular system, kidneys, and autonomic nervous system. Nutritional support for the liver must address these interactions to be effective. Feline Hepatic Support is formulated to support: ▶▶Liver metabolism ▶▶Hepatic circulation, bile production and flow ▶▶Hepatic immune function

Indications for Use ▶▶General hepatic support ▶▶Patients with increased metabolic demand ▶▶Patients in need of additional hepatic support as indicated by ALT, alkaline phosphatase, bile acids studies, low BUN, liver histopathology, or ultrasound

Adjunctive Products ▶▶Feline Renal Support ▶▶Feline Enteric Support ▶▶Feline Whole Body Support

Feline Formulas

Feline Hepatic Support

Supplement Facts Stated amounts depend on dose. Ingredients Bovine liver PMG™ extract, bovine liver, bovine and ovine spleen, bovine kidney, L-glutamine, Emblica officinalis, porcine stomach, bone meal, pea vine juice, porcine duodenum, buckwheat leaf juice and seed, Strombus gigas, oat flour, bovine kidney PMG™ extract, defatted wheat germ, nutritional yeast, bovine liver fat extract, bovine adrenal, Silybum marianum, beet leaf juice, beet root, inositol, choline bitartrate, alfalfa juice, rice bran, copper liver chelate, zinc liver chelate, iron liver chelate, and extract of Rhizopus oryzae grown on Tillandsia usneoides and beet root. Other Ingredients Honey and calcium stearate as tableting aids. Minerals Sodium. . . . . . 7 mg / tablet Chloride. . . . . 7 mg / tablet Iron . . . . . . . . 150 mcg / tablet

Copper . . . . . . 15 mcg / tablet Zinc . . . . . . . . 21 mcg / tablet

Content Product No. 60 tablets . . . . A5200

How to Administer The feline patient should receive one tablet two times per day, or as directed. Feline formulas can be administered in a variety of ways, including: ▶▶ Whole tablet or crushed ▶▶ Dosed directly or mixed with food ▶▶ Cautiously, as a powder suspended in water given by oral syringe To familiarize the cat with the supplement, it may be helpful to place one tablet beside the food bowl for two or three days prior to mixing the tablet with the food.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please consult the product packaging label for the most accurate product information.

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Feline Formulas

Feline Immune System Support The immune system is a complex array of cells that are found throughout the body. Immune cells are designed to work in conjunction with each other to provide a defense against unwanted invaders. The complexity of the immune system requires a multidimensional approach to nutritional factors. Nutritional support of the immune system is directed at facilitating normal function and is not intended to be suppressive or stimulating. Feline Immune System Support: ▶▶Provides nutritional and biochemical support for healthy immune cells and tissues ▶▶Supports optimal immune protection

Indications for Use ▶▶General immune system support ▶▶Colder climates or during the fall/winter months ▶▶When kenneled or in a shelter

Adjunctive Products ▶▶Feline Whole Body Support ▶▶Feline Enteric Support

Supplement Facts Stated amounts depend on dose. Ingredients Eleutherococcus senticosus, bovine liver, L-glutamine, porcine jejunum, bovine orchic Cytosol™ extract, Emblica officinalis, ribonucleic acid, bovine and ovine spleen, bovine spleen PMG™ extract, bovine thymus Cytosol™ extract, bovine pituitary PMG™ extract, bovine adrenal Cytosol™ extract, buckwheat leaf juice and seed, pea vine juice, bovine hypothalamus Cytosol™ extract, oat flour, bovine kidney, bovine thyroid PMG™ extract, alfalfa juice, copper liver chelate, iron liver chelate, zinc liver chelate, kelp, and bovine pancreas PMG™ extract. Other Ingredients Honey and calcium stearate as tableting aids. Minerals Potassium. . . . 3.5 mg / tablet Iron . . . . . . . . 140 mcg / tablet

Copper . . . . . . 20 mcg / tablet Zinc . . . . . . . . 70 mcg / tablet

Content Product No. 60 tablets . . . . A5300

How to Administer The feline patient should receive one tablet two times per day, or as directed. Feline formulas can be administered in a variety of ways, including: ▶▶ Whole tablet or crushed ▶▶ Dosed directly or mixed with food ▶▶ Cautiously, as a powder suspended in water given by oral syringe To familiarize the cat with the supplement, it may be helpful to place one tablet beside the food bowl for two or three days prior to mixing the tablet with the food.

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Please consult the product packaging label for the most accurate product information.

For renal challenges, not only should the kidneys be supported but consideration should also be given to support of the liver, cardiovascular system, and autonomic nervous system. Feline Renal Support: ▶▶Facilitates support and natural rehabilitation of the kidneys ▶▶Provides balanced cellular nutrition for all aspects of urinary system function

Indications for Use ▶▶Patients in need of renal support as indicated by BUN, creatinine, phosphorus, urine specific gravity ▶▶Hepatic patients in need of additional renal support

Adjunctive Products ▶▶Feline Hepatic Support ▶▶Feline Cardiac Support ▶▶Feline Whole Body Support

Supplement Facts

Feline Formulas

Feline Renal Support

Stated amounts depend on dose. Ingredients Bovine kidney PMG™ extract, bovine kidney, bovine liver, veal bone PMG™ extract, bone meal, defatted wheat germ, bovine and ovine spleen, buckwheat leaf juice and seed, Emblica officinalis, oat flour, pea vine juice, bovine adrenal Cytosol™ extract, ribonucleic acid, alfalfa juice, bovine heart PMG™ extract, kidney bean extract, Strombus gigas, Tillandsia usneoides, rice bran, porcine duodenum, beet leaf juice, beet root, and extract of Rhizopus oryzae grown on Tillandsia usneoides and beet root. Other Ingredients Honey and calcium stearate as tableting aids. Minerals Calcium. . . . . . 3.5 mg / tablet Phosphorus. . . 2.4 mg / tablet

Sodium. . . . . . 15 mg / tablet

Content Product No. 60 tablets . . . . A5400

How to Administer The feline patient should receive one tablet two times per day, or as directed. Feline formulas can be administered in a variety of ways, including: ▶▶ Whole tablet or crushed ▶▶ Dosed directly or mixed with food ▶▶ Cautiously, as a powder suspended in water given by oral syringe To familiarize the cat with the supplement, it may be helpful to place one tablet beside the food bowl for two or three days prior to mixing the tablet with the food.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Please consult the product packaging label for the most accurate product information.

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Feline Formulas

Feline Whole Body Support Many cats have a diet limited to highly processed pet foods. Supplements made with whole food ingredients, organ and tissue extracts, botanicals, and other ingredients can fill the nutrition gap created by feeding processed foods. Feline Whole Body Support: ▶▶Provides general multisystem support for daily maintenance of all body systems with emphasis on a healthy endocrine system ▶▶Is an excellent nutritional foundation for use with all other system-support formulas

Indications for Use ▶▶Daily supplement for any patient ▶▶Growing animals ▶▶Active animals ▶▶Endocrine system support ▶▶Pregnancy/lactation ▶▶Senior animals

Adjunctive Products ▶▶Feline Hepatic Support ▶▶Feline Enteric Support ▶▶Feline Renal Support

Supplement Facts Stated amounts depend on dose. Ingredients Bovine liver, bovine and ovine spleen, alfalfa juice, bovine liver PMG™ extract, bovine trachea, bone meal, bovine heart PMG™ extract, L-glutamine, bovine kidney, rice bran, porcine jejunum, Emblica officinalis, bovine kidney PMG™ extract, buckwheat leaf juice and seed, oat flour, bovine adrenal Cytosol™ extract, nutritional yeast, pea vine juice, bovine orchic Cytosol™ extract, high chromium yeast, Strombus gigas, beet leaf juice, beet root, zinc liver chelate, L-carnitine, maltodextrin, defatted wheat germ, kidney bean extract, inositol, allantoin, choline bitartrate, and extract of Rhizopus oryzae grown on Tillandsia usneoides and beet root. Other Ingredients Honey and calcium stearate as tableting aids. Minerals Sodium. . . . . . 5 mg / tablet Zinc . . . . . . . . 180 mcg / tablet

Chromium. . . . 5 mcg / tablet

Content Product No. 60 tablets . . . . A5500

How to Administer The feline patient should receive one tablet two times per day, or as directed. Feline formulas can be administered in a variety of ways, including: ▶▶ Whole tablet or crushed ▶▶ Dosed directly or mixed with food ▶▶ Cautiously, as a powder suspended in water given by oral syringe To familiarize the cat with the supplement, it may be helpful to place one tablet beside the food bowl for two or three days prior to mixing the tablet with the food.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Please consult the product packaging label for the most accurate product information.

Equine Formulas

Equine Formulas The equine formulas contain ingredients such as vegetables, herbs, and fruits to deliver a full spectrum of phytonutrients, enzymes, minerals, and vitamins in their most potent form. Safe and effective, these formulas were developed to target the nutritional demands of specific systems. The equine formulas are in powder form and do not contain any animal tissues.

Equine Formulas

Equine GI Support Product Overview The equine gastrointestinal (GI) tract is an extensive set of organs that must function as a synergistic team to maintain: healthy intestinal function, a healthy stomach lining, a normal appetite, a cooperative working attitude, and a pleasant disposition.

▶▶Lining of the stomach ▶▶Healthy bacterial populations in the intestine ▶▶Energy generation ▶▶Oxidation processes Equine GI Support can be added to a balanced equine diet to ensure smooth operation of the horse’s:

▶▶Liver function ▶▶Immune responses Equine GI Support can be used for either short- or long-term support.

Content 30 ounces (850 g)

Servings Per Container 28

▶▶Liver detoxification pathways

▶▶Hind gut

Product Number E7700

Serving Size ¼ cup (30 g)

Equine GI Support is backed by research-proven ingredients that support:

▶▶Upper GI tract

Supplement Facts

Ingredients Whey (milk) protein powder, flax meal, L-glutamine, inulin, rice protein powder, Brussels sprouts (whole plant), kale (whole plant), corn starch, calcium citrate, magnesium citrate, buckwheat (leaf), choline bitartrate, inositol, chamomile extract, barley (grass), alfalfa (whole plant) juice powder, gum acacia, grape (seed) extract, soybean lecithin powder, mixed tocopherols, carrot (root) powder, and red wine extract. Suggested Use ¼ cup (30 g)/1,000 lb. horse/day, or as directed. Warnings For equine use only. Keep all supplements out of the reach of children and other animals. In case of accidental overdose, contact a health care professional immediately. Precautions Safe use in pregnant animals or animals for breeding has not been proven.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Please consult the product packaging label for the most accurate product information.

Brussels sprouts and kale: Cruciferous vegetables like Brussels sprouts and kale influence detoxification pathways.These vegetables contain compounds called glucosinolates and an enzyme called myrosinase.When crucifers are cut or chewed, myrosinase enzymes act on the glucosinolates to make them into other compounds that have demonstrated (via cell, animal, and epidemiological studies) an increase in the activation of detoxification enzymes.1, 2 Chamomile: This well-known herb has a long history of traditional use as support for the stomach lining, complete digestive system, and immune system balance. Chamomile is also thought to act as a natural calmative that relaxes while still maintaining a positive energy level. Equine GI Support contains chamomile that is standardized to contain 1.2 percent apigenin, a key flavonoid linked to a number of health effects in animal studies.3, 4

Equine Formulas

Key Ingredients

This ingredient could be considered a controlled substance by certain entities that govern equine competitions. We advise those who feed any supplement to competing horses to check with the governing body specific to the event regarding whether the product contains ingredients that could be considered a controlled substance.

Inulin: This nondigestible fiber supports the cecum in horses. Levels of up to 2 percent in feed improved fermentation in the cecum without any adverse effects. In humans, inulin shows preferential support for Bifidobacteria populations, while promoting healthy bacteria and pH in the gut. Inulin also supports immune-cell function and antibody production in the gut, absorption of calcium and magnesium, and healthy elimination. 5, 6, 7, 8 L-glutamine: Glutamine is an amino acid that is used as a building block for other amino acids and compounds like glutathione. Some of our cells that require a lot of energy (like those in the gut) can use glutamine as an energy source. In this way, glutamine supports the integrity of the intestinal lining and the immune cells associated with the intestines. This amino acid can be depleted by stress, which can in turn slow the body’s natural regeneration and healing process.9, 10 Vitamin E: This fat-soluble vitamin has antioxidant properties that support the body under stress. Stress is often associated with an increase in oxidation products that could damage cells.

Clinical Perspective “I have had the privilege of trialing the Equine GI Support supplement on several of my equine patients. In my findings, this product was very beneficial for horses with temperament issues and for general GI support. Horses on the supplement displayed a much calmer demeanor and appeared to be much more comfortable in their environment, whether that was in a stall or out to pasture. Horses challenged by environmental factors before being put on Equine GI Support showed improvement once put on the product. “I feel very comfortable advising my clients to use Equine GI Support, because of its whole food ingredients and because I know Standard Process does extensive quality control testing on all of its products.” —Richard Tully, DVM | Standard Process supervising veterinarian of equine clinical research

“Sundi, my 9-year-old Percheron/thoroughbred mare that I use for dressage and jumping, had digestive issues and frequently consumed dirt by the mouthful.Then a colleague of mine mentioned there was a GI product in the research phases that had helped her own horse.Taking her suggestion, I started Sundi on Equine GI Support. Ever since, she has had no further issues to speak of, and she has stopped eating dirt. “It has been such a relief to have her feeling well consistently! Since starting Equine GI Support, Sundi has also seemed quieter and more responsive overall, which makes riding and being around her much more enjoyable.” —Stephanie Byrket, DVM 27

Equine Formulas

Equine Immune Support Product Overview The equine immune system faces countless stressors year-round. Training, competition, travel, environmental factors, and lack of turnout can all take a toll. Equine Immune Support is a complex supplement for a complex system, caring for the interlocking cells and organisms that coordinate activity to recognize what belongs in the body and what doesn’t. Equine Immune Support encourages an optimal immune response—either defensively or offensively—to safeguard the health, performance, and stamina of the horse by supporting: ▶▶Immune-cell signaling ▶▶Antioxidant activities ▶▶Cell integrity ▶▶Nutritional status This supplement is uniquely designed with whole food and other ingredients to:

Supplement Facts Product Number E7800 Content 30 ounces (850 g) Serving Size ¼ cup (30 g) Servings Per Container 28 Ingredients Whey (milk) protein powder, flax meal, L-glutamine, turmeric (root) extract, maltodextrin, rice protein powder, mushroom powder (Coriolus versicolor), mushroom powder (reishi/shiitake), yeast culture, calcium citrate, magnesium citrate, buckwheat (leaf), Brussels sprouts (whole plant), kale (whole plant), choline bitartrate, inositol, barley (grass), alfalfa (whole plant) juice powder, grape (seed) extract, soybean lecithin powder, arabic gum, starch, sucrose (beets), carrot (root), vitamin A palmitate, cholecalciferol, and red wine extract.

▶▶Support the entire body while targeting vital aspects of immune system response

Suggested Use ¼ cup (30 g)/1,000 lb. horse/day, or as directed.

▶▶Help the body respond in the most appropriate way in times of need, whether that is by stimulating or calming the normal, healthy immune response

Warnings For equine use only. Keep all supplements out of the reach of children and other animals. In case of accidental overdose, contact a health care professional immediately.

Equine Immune Support can be used for either shortor long-term support.

Precautions Safe use in pregnant animals or animals for breeding has not been proven.

Key Ingredients L-glutamine: This amino acid is a universal energy substrate for cells throughout the body, especially those of the immune system. Glutamine’s broad role in metabolism supports the body’s natural regeneration and healing processes.1, 2 Turmeric: In-vitro and animal studies have shown that curcumin, just one of many phytochemicals in turmeric, supports the downregulation of inflammatory cytokines, displays antioxidant properties, and modulates a wide range of cell-signaling molecules.3, 4, 5

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Please consult the product packaging label for the most accurate product information.

▶▶Turkey tail mushroom’s support for immune function is mainly attributed to a protein-bound polysaccharide and has been shown to support the antibody-mediated immune response.6 ▶▶Shiitake has a long history of traditional use for immune stimulation, cholesterol processing, and overall support for aging.7, 8 ▶▶Reishi is traditionally used to support cholesterol already within a normal range, blood flow, stamina, and antibody-mediated immune response.9, 10, 11, 12

Equine Formulas

Mushrooms: Shiitake (Lentinula edodes), reishi (Ganoderma lucidum), and turkey tail (Coriolus versicolor) mushrooms have a long history of use for immune support in traditional Chinese medicine.

Vitamin A palmitate: This vitamin is critical for maintaining epithelial-cell integrity, eye health, and kidney and immune function. Vitamin A palmitate is included in Equine Immune for support of epithelial tissue—a front-line barrier in immune response.13 Vitamin D: Receptors for vitamin D are in almost every immune cell, and current research suggests that vitamin D helps regulate T cells, leading to moderation of the normal inflammatory process. Horses that are kept indoors or get limited sun exposure might not have the opportunity to make sufficient endogenous vitamin D.14 Yeast culture: Yeast cultures have more than 60 years of use in supporting immune status in animals, including livestock, poultry, dogs, and cats. Research in horses suggests that the addition of yeast cultures supports a healthy gut environment and nutrient availability.15, 16, 17

Clinical Perspective “I began trialing Equine Immune Support after determining that it was an interesting mix of safe and evidence-based ingredients.We began several horses on the product that showed immune-related seasonal environmental issues. In my observations, the horses on the Equine Immune Support showed less reactivity to environmental challenges and substances in comparison to past springs and summers prior to using the supplement. Once the horses were put on Equine Immune Support, these horses could proceed with few or no challenges.These horses were also subjectively observed to be more comfortable in their environment and seemed more relaxed and less anxious. Changes in habits were evident, especially tail-rubbing habits.” —Richard Tully, DVM | Standard Process supervising veterinarian of equine clinical research

“A 3-year-old saddlebred was dermatologically challenged. Only Equine Immune Support was used for treatment, and the condition cleared up over a couple of weeks.The coat came back more beautiful than before.” —Heather Forry, DC (equine)

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Equine Formulas

Equine Metabolic Support Product Overview The metabolic system is complex, involving organs such as the thyroid, liver, kidneys, and pancreas. Some signs indicative of metabolic stress may include: ▶▶Changes in insulin levels ▶▶Seasonal pasture sensitivities

Supplement Facts Product Number E7900 Content 40 ounces (1134 g) Serving Size ¼ cup (37 g)

▶▶Immune system challenges ▶▶Excess weight or fatty deposits

Servings Per Container 30

Equine Metabolic Support:

Ingredients Buckwheat flour, carrot powder, cinnamon, licorice (root), green tea extract, cayenne, chromium yeast, and vanadium chelate (rice and soy).

▶▶Promotes healthy glucose metabolism and insulin function ▶▶Provides antioxidant activity

Suggested Use ¼ cup (37 g)/1,000 lb. horse/day, or as directed.

▶▶Supports the endocrine system Equine Metabolic Support can be used for either short- or long-term support.

Key Ingredients Licorice root: There is evidence that licorice root can help maintain glucose homeostasis as well as pituitary hormone homeostasis.1 Licorice may directly impact the underlying pituitary imbalance.

Warnings For equine use only. Do not administer to cattle or other ruminants. Keep all supplements out of the reach of children and other animals. In case of accidental overdose, contact a health care professional immediately. Precautions Safe use in pregnant animals or animals for breeding has not been proven.

Cinnamon: There is evidence that components of cinnamon can modulate glucose homeostasis.2-13 By maintaining normal glucose levels, it may be possible to bring other endocrine signals back to normal. Cayenne (chili powder): As with cinnamon, there is increasing evidence that chili powder can help maintain normal glucose levels. The mechanism is unclear. Regular consumption of chili may attenuate postprandial hyperinsulinemia.5, 7 This ingredient could be considered a controlled substance by certain entities that govern equine competitions. We advise those who feed any supplement to competing horses to check

with the governing body specific to the event regarding whether the product contains ingredients that could be considered a controlled substance.

Buckwheat flour: Buckwheat seed and juice contain a variety of flavonoids including rutin. Flavonoids are primarily found conjugated to sugar molecules. In this form there is evidence that they can compete with other sugars for uptake into the body. This might effectively slow the absorption of sugar and lessen the postprandial glucose surge. This would lessen the concomitant insulin spike. In addition, rutin has been implicated in the maintenance of capillary integrity and, along with the other flavonoids, provides antioxidant activity.14-19 Green tea extract: Contains catechins/polyphenols that may work in a similar fashion as the flavonoids found in buckwheat. Additionally, catechins/polyphenols have strong antioxidant properties and interact with a number of signaling pathways related to immune system response. Chromium: Potentiates insulin actions and combines with several other components to make the glucose tolerance factor.20-26 Vanadium: Can mimic insulin’s actions. It is possible that by slowing glucose metabolism, improving blood glucose levels, and mimicking insulin’s actions, circulating levels in a horse with metabolic challenges may be reduced.27-34 30

Please consult the product packaging label for the most accurate product information.

Figure 1: Average serum level and corresponding blood glucose

Twenty-nine horses were identified with elevated insulin, which can be associated with challenges to the metabolic system. Four veterinarians participated in the evaluations and recommended appropriate changes in diet and exercise. The animals were given ¼ cup (approximately 2 ounces) of Equine Metabolic Support daily for four months. Results The response in fasting insulin levels varied but predominantly decreased (20 animals). Six animals had variable responses, and three animals had increased circulating insulin levels. Figure 1 shows the average serum insulin level and corresponding blood glucose levels over the course of the trial for all animals. Even though blood glucose levels rose slightly, they still remained within the normal range for a horse.

Equine Formulas

Clinical Evaluations

Clinical Perspective “Rico is a 21-year-old Paso Fino gelding who has won multiple titles in his lifetime. At the start of the study, he was overweight with a body score of 8 out of 9. He was lame and had a fasting serum insulin of greater than 1,600 pmol/L. His neck was heavy and cresty. He had fat pads, especially on the thorax and around his tail. He was placed on a course of Equine Metabolic Support. He lost significant mass on his neck, the fat pads dramatically diminished, and his fasting serum insulin was less than 200, all after just one month on Equine Metabolic Support. His body score was estimated at 6 out of 9. He was also walking without evidence of pain. It should be noted that Equine Metabolic Support was the only treatment Rico received. Rico subsequently went off Equine Metabolic Support after five months, and his body score returned to a level approximately 8 out of 9.The owners have now put Rico back on Equine Metabolic Support, and he is responding in a manner to that originally observed.” —Richard Tully, DVM | Standard Process supervising veterinarian of equine clinical research

Before

After

Before

After

Note:Variations in coat color are due to pictures being taken during different seasons in Wisconsin.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

31

Equine Formulas

Equine Mobility Support Product Overview Equine joints inevitably suffer stress during daily riding, training, and competing. Friction and load-bearing stress on a horse’s joints ultimately affect comfort and performance, sometimes even before the signs are apparent. Equine Mobility Support is a scientifically researched formula comprised of whole food ingredients that can help:

Supplement Facts Product Number E8000 Content 40 ounces (1134 g) Serving Size ¼ cup (33 g)

▶▶Stimulate cartilage growth and maintain joint health ▶▶Promote bone growth and restoration

Servings Per Container 30

Equine Mobility Support:

Ingredients Flax meal, glucosamine sulfate (4 g), ginger (root), chondroitin sulfate (1.5 g), wheat germ oil, honey, and cinnamon.

▶▶Promotes healthy joint function, flexibility, and mobility

Suggested Use ¼ cup (33 g)/1,000 lb. horse/day, or as directed.

▶▶Supports the natural repair system of joints

Warnings For equine use only. Do not administer to cattle or other ruminants. Keep all supplements out of the reach of children and other animals. In case of accidental overdose, contact a health care professional immediately.

▶▶Supply omega-3 fatty acids

▶▶Supplies antioxidant activity to help protect against damage from free radicals ▶▶Supports a healthy inflammatory response and full and firm stride

Key Ingredients

Precautions Safe use in pregnant animals or animals for breeding has not been proven.

Glucosamine sulfate: An important component of cartilage growth, maintenance, and repair. While research is ongoing in horses, meta-analysis of human clinical trials has confirmed the value of glucosamine in support of bone health.1, 2, 3 In the horse, glucosamine has been implicated in regulation of matrix metalloproteinase expression, an important enzyme working in joint tissues.4, 5 Chondroitin sulfate: An important component of the extracellular matrix of connective tissue. Low-molecularweight chondroitin sulfate is bioavailable in the horse, although to a limited degree.6 While the mechanism of chondroitin sulfate action in joint health remains to be determined, chondroitin sulfate is an important component of compounds found in various functional components of the joint. Wheat germ oil: Provides a rich source of vitamin E, which promotes healthy circulation, enhances athletic performance, and helps reduce muscle cramping.Vitamin E is an important lipophilic antioxidant implicated in a number of physiological functions. Tocopherols support immune function and lessen the inflammatory response by scavenging reactive oxygen species. Flax meal: Contains significant levels of omega-3 fatty acids, specifically alpha-linolenic acid (ALA) and omega-3 fatty acids, which have been implicated in reducing the inflammatory response. Studies have shown that omega-3 fatty acids reduced inflammatory thromboxane and decreased endotoxin-induced TNF production in horses.7, 8 Ginger: Contains a broad spectrum of bioactive compounds. Several ginger compounds have well-documented effects on the inflammatory response. For example, 6-gingerol and 6-paradol have such activity, while 8-paradol and 9-shagaol have been shown to inhibit COX-2 activity. This action may explain ginger’s historic uses.9, 10 This ingredient could be considered a controlled substance by certain entities that govern equine competitions. We advise those who feed any supplement to competing horses to check with the governing body specific to the event regarding whether the product contains ingredients that could be considered a controlled substance.

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Please consult the product packaging label for the most accurate product information.

Horses representing different breeds, ages, and gender were evaluated prior to initiating the study to define their level of lameness. Animals having a spavin score of greater than 1 in a leg joint were recruited. Fifteen horses were enrolled in the study and were given ¼ cup (approximately 2 ounces) of Equine Mobility Support daily for 60 days. Equine participants were re-evaluated at 30-day intervals. Change in spavin score, or lack thereof, was noted after 30 and 60 days. Serum chemistries and complete blood-cell counts were performed prior to and during the study to assure no unexpected side effects developed during the study. With one exception, all horses showed improvement of aggregate spavin score (total for all limbs) by 30 days. At 60 days, all horses showed continued improvement. In addition, there were no actionable changes in blood chemistries. Subjective comments from the trainers involved indicated many animals showed greater range in motion. Second Trial: Eighteen additional animals were recruited for assessment. These animals were more active (dressage, endurance, jumping, therapy) and likely to exhibit different stress symptoms/indicators on their limbs. Sixteen animals finished the 60-day trial with a similar protocol. The results support those found in the initial trial.

Equine Formulas

Clinical Evaluation

Figure 1: Effect of Equine Mobility Support on lameness (aggregate data)

These studies contained no control group and represent the observations and measurements by the attending veterinarian.

Clinical Perspective “Michael is a 21-year-old ex-racehorse that is very active in his daily pasture turnout. Michael had been on top-of-the-line joint supplements through the years. But it wasn’t until we put him on Equine Mobility Support that we saw significant improvement in his condition. “He had been uncomfortable on a daily basis and overtly lame on a weekly basis. He is now comfortable in his retirement and his owner is very happy. “It’s been a bonus that Michael readily consumes the product. He’s quite picky about anything new in his feed, but he readily ate the Equine Mobility Support from the start.” —Debra Tibbitts, DVM

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Equine Formulas

Equine Performance Product Overview

Supplement Facts

Rigorous training and competition can bring on an inflammatory response, exercise-related muscle soreness, and oxidative stress. Regardless of the discipline, quick muscle recovery and optimal energy levels are essential. Equine Performance is specially formulated to help return the entire body to equilibrium following physical stress.

Product Number E8100 Content 30 ounces (850 g) Serving Size ¼ cup (30 g)

The ingredients in Equine Performance complement each other to: ▶▶Support energy-related pathways ▶▶Provide energy substrates (nucleotides, ribose, amino acids) ▶▶Offer antioxidant activity, cognition, and activityrelated inflammation support Equine Performance supports the body’s: ▶▶Nutritional supplement needs

Servings Per Container 28 Ingredients Whey (milk) protein powder, flax meal, L-glutamine, glutamic acid, nutritional yeast, rice protein powder, tart cherry powder, ribonucleic acid, calcium citrate, magnesium citrate, selenium yeast (550 mcg selenium), buckwheat (leaf), Brussels sprouts (whole plant), kale (whole plant), choline bitartrate, inositol, barley (grass), alfalfa (whole plant) juice powder, soybean lecithin powder, grape (seed) extract, carrot (root) powder, and red wine extract. Suggested Use ¼ cup (30 g)/1,000 lb. horse/day, or as directed.

▶▶Cellular activity ▶▶Muscle-rebuilding processes Equine Performance is equally suitable for short- or long-term support.

Warnings For equine use only. Keep all supplements out of the reach of children and other animals. In case of accidental overdose, contact a health care professional immediately.

Key Ingredients

Precautions Safe use in pregnant animals or animals for breeding has not been proven.

Glutamate: Central to reactions that generate energy and support the excretion of excess/waste compounds from the body. The addition of this amino acid during exercise supports tissue levels of glutamate and alanine while also reducing ammonia during and following exercise.1 L-glutamine: This amino acid is a universal energy substrate for hard-working cells throughout the body, like those of the immune and gastrointestinal tract.2, 3 Nutritional yeast: A rich source of natural B vitamins, nutritional yeast is included to support overall cell functions, especially those related to energy metabolism, as well as cognitive function.4, 5

34

Please consult the product packaging label for the most accurate product information.

Selenium: Selenium is part of the protection mechanisms within cells. As an essential component of glutathione peroxidase, selenium supports the metabolism of oxidation products within cells. Selenium also plays a role in thyroid hormone metabolism.7, 8, 9

Equine Formulas

RNA: RNA contains nucleotides, the building blocks of energy molecules like adenosine triphosphate (ATP), cytidine triphosphate (CTP), and guanosine triphosphate (GTP). These molecules support metabolism. The RNA in this product is added to provide a larger pool of “raw materials” for the base energy systems that fuel the body. RNA also provides ribose, an excellent energy source to support peak performance.6

Tart cherry: Historically used for activity-based inflammatory response, this ingredient’s mechanism of action is still unknown. Human studies have found improvements in muscle strength and comfort in those consuming tart cherry as compared to those consuming a placebo.10, 11

Clinical Perspective “I began trialing Equine Performance in several endurance horses after determining that the ingredients were both safe and research based. In my observations of Equine Performance, I found that horses subjectively exhibited quicker pulse and respiratory recovery times post-exercise, than they had prior to starting the supplement. Animals also appeared to be more comfortable after exercise, showing less signs of cramping, exercise-related muscle soreness, and fatigue.This perception of improved recovery is being evaluated by monitoring blood lactate levels. “I recommend this supplement as a great way to support the equine athlete, and I feel comfortable advising clients to use this product, because of its whole food ingredients and extensive quality control and safety testing.” —Richard Tully, DVM | Standard Process supervising veterinarian of equine clinical research

“I have been using Equine Performance in my equine chiropractic practice. Equine Performance has cut the frequency of adjustments and recovery time in half.The horses are able to hold their adjustments sooner and for a longer period of time. “I had a 5-year-old saddlebred patient that several chiropractors and vets had seen but had never successfully relieved of the inflammatory response over the sacral area.Within three days of using Equine Performance, there was a dramatic decrease. Not to mention, the coat looked healthier, so the overall health of the animal had improved. Equine Performance has become a staple in my practice, and I have used it on several breeds with a wide age range and have yet to not see a difference. “A 7-year-old quarter horse that had surgery two years ago and had pins and screws in the front right shoulder stressed it somehow, causing massive swelling around the joint.The owner called me, and after one month of adjustments and the Equine Performance, he is back to galloping around the field. Life changing!” —Heather Forry, DC (equine)

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

35

Equine Formulas

Feeding Tips Here are a few tips to make sure horses consume their daily dose of supplement: ▶▶Start slowly. Introduce the product in small amounts to let the animal get used to the taste. ▶▶Make a wet feed so the powder mixes in with the rations. This will also prevent the powder from falling to the bottom of the bucket. ▶▶Mix with sugar-free applesauce and horse’s feed. ▶▶Make a mash using commonly found low-starch and pelleted feeds or soaked hay cubes. ▶▶Mix with applesauce and syringe directly into mouth.

References Equine GI Support

1. Robbins MG, Andersen G, Somoza V, Eshelman BD, Barnes DM, Hanlon PR. Heat treatment of Brussels sprouts retains their ability to induce detoxification enzyme expression  in vitro  and  in vivo. J Food Sci. 2011 Apr; 76(3):C454-61. 2. Robbins MG, Hauder J, Somoza V, Eshelman BD, Barnes DM, Hanlon PR. Induction of detoxification enzymes by feeding unblanched Brussels sprouts containing active myrosinase to mice for 2 wk. J Food Sci. 2010 Aug 1;75(6):H190-9. 3. Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010 Sep; 29(3):405-34. 4. Amsterdam JD, et al. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol. 2009; 29(4):378-82. 5. Van Loo J. How chicory fructans contribute to zootechnical performance and well-being in livestock and companion animals. J. Nutr. 2007; 137(11): 2594S-2597. 6. Kleessen B, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M. Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers. Br J Nutr. 2007 Sep; 98(3):540-9. Epub 2007 Apr 20. 7. Watzl B., Girrbach S., and Roller M. Inulin, oligofructose and immunomodulation. Br J Nutr. 2005; 93 Suppl 1: p. S49-55. 8. Scholz-Ahrens K.E., et al., Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure. J Nutr, 2007. 137(3 Suppl 2): p. 838S-46S. 9. Ehrlich SD. (2009, June 20) Complementary medicines. Glutamine. July 29, 2011; http://www.umm.edu/altmed/articles/glutamine-000307.htm. 10. Lacey JM and Wilmore DW. Is glutamine a conditionally essential amino acid? Nutrition Reviews.2009; 48(8): 297-309.

Equine Immune Support

1. Ehrlich, SD. (2009, June 20) Complementary medicines. Glutamine. July 29, 2011; http://www.umm.edu/altmed/articles/glutamine-000307.htm. 2. Lacey, JM., Wilmore, DW. Is glutamine a conditionally essential amino acid? Nutrition Reviews 2009; 48(8): 297-309. 3. Nandal S, Dhir A, Kuhad A, Sharma S, Chopra K. Curcumin potentiates the anti-inflammatory activity of cyclooxygenase inhibitors in the cotton pellet granuloma pouch model. Methods Find Exp Clin Pharmacol. 2009 Mar;31(2):89-93. 4. Kolodziejczyk J, Olas B, Saluk-Juszczak J, Wachowicz B. Platelets. Antioxidative properties of curcumin in the protection of blood platelets against oxidative stress in vitro. 2011; 22(4):270-6. Epub 2011 Feb 8. 5. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of turmeric (Curcuma longa). J Altern Complement Med. 2003; 9(1):161-8. 6. Jeong SC, Yang BK, GN K, et al. Macrophage-stimulating activity of polysaccharides extracted from fruiting bodies of Coriolus versicolor (Turkey Tail Mushroom). J Med Food. 2006;9:175-181. 7. Hobbs C. Medicinal Mushrooms, 3rd ed. Loveland (CO): Interweave Press; 1996. 8. Darmadi I, et al. Food and nutrient intakes and overall survival of elderly Japanese. Asia Pacific J Clin Nutr 2000; 9(1):7-11. 9. Kim SD. Isolation and structure determination of a cholesterol esterase inhibitor from Ganoderma lucidum. J Microbiol Biotechnol. 2010 Nov.; 20(11):1521-3. 10. Kumaran S, Palani P, Nishanthi R, Kaviyarasan V. Studies on screening, insolation and purification of a fibrinolytic protease from an isolate (VK12) of Ganoderma lucidum and evaluation of its antithrombotic activity. Med Mycol J. 2011; 52(2):153-62. 11. Shiao MS.; Lee, KR.; Lin, LJ., Wang, CT. (1994) Natural products and biological activities of the Chinese medical fungus, Ganoderma lucidum, in: Food Phytochemicals for Cancer Prevention. II: Teas, Spices and Herbs, (Ho, CT., Osawa, T., Huang, M.T. and Rosen, R.T.; Eds.), American Chemical Society: Washington, DC, p. 342-354. 12. Lin ZB, Zhang HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004 Nov; 25(11):1387-95. 13. Semba RD. Impact of vitamin A on immunity and infection in developing countries. In: Bendich A, Decklebaum RJ, eds. Preventitive Nutrition: The Comprehensive Guide for Health Professionals. 2nd ed. Totowa: Humana Press Inc; 2001:329-346. 14. Marques CD, Dantas AT, Fragoso TS, Duarte AL. The importance of vitamin D levels in autoimmune diseases. [Article in English, Portuguese] Rev Bras Reumatol. 2010 Feb; 50(1):67-80. 15. Agazzi A, et al. Evaluation of the effects of live yeast supplementation on apparent digestibility of high-fiber diet in mature horses using the acid insoluble ash marker modified method. J of Equine Vet Sci. 2011; 31(1):13-18. 16. Jouany JP, Gobert J, Medina B, Bertin G, and Julliand V. Effect of live yeast culture supplementation on apparent digestibility and rate of passage in horses fed a high-fiber or high-starch diet. Journal of Animal Science 2008; 86: 339-347. 17. Médina B, Girard ID., Jacotot E, Julliand V. Effect of a preparation of Saccharomyces cerevisiae on microbial profiles and fermentation patterns in the large intestine of horses fed a high fiber or a high starch diet. Journal of Animal Science 2002; 80: 2600-2609.

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1. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. Acta Diabetol.Lat. 1989;26(1):51-55. 2. Huss U, Ringbom T, Perera P, Bohlin L, Vasange M. Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. J Nat Prod. 2002;65(11):1517-1521. 3. Reddy AM, Seo JH, Ryu SY, Kim YS, Kim YS, Min KR, Kim Y. Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia. Planta Med 2004;70(9):823-827. 4. Dragland S, Senoo H, Wake K, Holte K, Blomhoff R. Several culinary and medicinal herbs are important sources of dietary antioxidants. J Nutr 2003;133(5):1286-1290. 5. Shobana S, Naidu KA. Antioxidant activity of selected Indian spices. Prostaglandins Leukot. Essent. Fatty Acids 2000;62(2):107-110. 6. Berrio LF, Polansky MM, Anderson RA. Insulin activity: stimulatory effects of cinnamon and brewer’s yeast as influenced by albumin. Horm.Res 1992;37(6):225-229. 7. Broadhurst CL, Polansky MM, Anderson RA. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric.Food Chem 2000;48(3):849-852. 8. Imparl-Radosevich J, Deas S, Polansky MM, Baedke DA, Ingebritsen TS, Anderson RA, Graves DJ. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling. Horm.Res 1998;50(3):177-182. 9. Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll.Nutr 2001;20(4):327-336. 10. Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003;84(1):105-108. 11. Kreydiyyeh SI, Usta J, Copti R. Effect of cinnamon, clove and some of their constituents on the Na(+)-K(+)-ATPase activity and alanine absorption in the rat jejunum. Food Chem Toxicol 2000;38(9):755762. 12. Lee HS. Inhibitory activity of Cinnamomum cassia bark-derived component against rat lens aldose reductase. J Pharm Sci 2002;5(3):226-230. 13. Onderoglu S, Sozer S, Erbil KM, Ortac R, Lermioglu F. The evaluation of long-term effects of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J.Pharm.Pharmacol. 1999;51(11):1305-1312. 14. Boyle SP, Dobson VL, Duthie SJ, et al. Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study. Eur J Clin Nutr 2000;54(10):774-782. 15. Mathiesen FR. Arterial insufficiency in the leg treated with rutosides. A double blind trial. Vasa 1974;3(3):319-324. 16. Riabokon’ EN, Gavrilenko TI, Kornilina EM, et al. [The effect of Wobenzym on the atherogenic potential and inflammatory factors at the rehabilitation stage for patients who have had a myocardial infarct]. Lik Sprava 2000;(5):111-114. 17. Ihme N, Kiesewetter H, Jung F, et al. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial. Eur J Clin Pharmacol 1996;50(6):443-447. 18. Ortolani O, Conti A, De Gaudio AR, et al. Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome. Shock 2000;13(1): 14-18. 19. Mayer B, Schumacher M, Brandstatter H, et al. High-throughput fluorescence screening of antioxidative capacity in human serum. Anal Biochem 2001;297(2):144-153. 20. Anderson RA. Chromium in the prevention and control of diabetes. Diabetes Metab 2000;26(1):22-27. 21. Bahijri SM, Mufti AM. Beneficial effects of chromium in people with type 2 diabetes, and urinary chromium response to glucose load as a possible indicator of status. Biol Trace Elem Res 2002;85(2):97109. 22. Balk EM, Tatsioni A, Lichtenstein AH, Lau J, Pittas AG. Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care. 2007 Aug;30(8):2154-63. Epub 2007 May 22. 23. Hoeger WW, Harris C, Long EM, Hopkins DR. Four-week supplementation with a natural dietary compound produces favorable changes in body composition. Adv Ther. 1998 Sep-Oct;15(5):305-14. 24. Jovanovic L, Gutierrez M, Peterson CM. Chromium supplementation for women with gestational diabetes mellitus. J Trace Elem Exp Med 1999;12(2):91-97. 25. Kleefstra N, Houweling ST, Bakker SJ, et al. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care. 2007 May;30(5):1092-6. 26. Khan, A, Bryden, NA, Polansky, MM, Anderson, RA. Insulin potentiating factor and chromium content of selected foods and spices. Biol Trace Elem.Res 1990;24(3):183-188. 27. Vanadium - help for blood sugar problems? Treatment update. 8-1-1999;11(6):5-7. 28. Sakurai, H. A new concept: the use of vanadium complexes in the treatment of diabetes mellitus. Chem.Rec. 2002;2(4):237-248. 29. Shafrir, E, Spielman, S, Nachliel, I, Khamaisi, M, Bar-On, H, Ziv, E. Treatment of diabetes with vanadium salts: general overview and amelioration of nutritionally induced diabetes in the Psammomys obesus gerbil. Diabetes Metab Res.Rev. 2001;17(1):55-66. 30. Shao, J, Catalano, PM, Yamashita, H, Ishizuka, T, Friedman, JE. Vanadate enhances but does not normalize glucose transport and insulin receptor phosphorylation in skeletal muscle from obese women with gestational diabetes mellitus. Am.J.Obstet.Gynecol. 2000;183(5):1263-1270. 31. Shechter, Y. Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes. Diabetes 1990;39(1):1-5. 32. Shechter, Y, Shisheva, A. Vanadium salts and the future treatment of diabetes. Endeavour 1993;17(1):27-31. 33. Srivastava, AK. Anti-diabetic and toxic effects of vanadium compounds. Mol.Cell Biochem. 2000;206(1-2):177-182. 34. Thompson, KH, Orvig, C. Vanadium compounds in the treatment of diabetes. Met. Ions. Biol. Syst. 2004;41:221-252.

Equine Formulas

Equine Metabolic Support

Equine Mobility Support

1. Clegg DO, Reda DJ, Harris CL, et. al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006; 354:795-808. 2. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. 2000; 283:1469-1475. 3. Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev: CD002946; 2005. 4. Neil KM, Orth MW, Coussens PM, Chan PS, Caron JP. Effects of glucosamine and chondroitin sulfate on mediators of osteoarthritis in cultured equine chondrocytes stimulated by use of recombinant equine interleukin-1beta. Am J Vet Res. 2005; 66:1861-1869. 5. Chan PS, Caron JP, Orth MW. Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1-challenged bovine articular cartilage explants. Am J Vet Res. 2005; 66:1870-1876. 6. Du J, White N, Eddington ND. The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse. Biopharm Drug Dispos. 2004; 25:109-116. 7. McCann ME, Moore JN, Carrick JB, Barton MH. Effect of intravenous infusion of omega-3 and omega-6 lipid emulsions on equine monocyte fatty acid composition and inflammatory mediator production in vitro. Shock. 2000; 14:222-228. 8. Morris DD, Henry MM, Moore JN, Fischer JK. Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. Am J Vet Res. 1991; 52:528-532. 9. Surh Y. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res. 1999; 428:305-327. 10. Tjendraputra E, Tran VH, Liu-Brennan D, Roufogalis BD, Duke CC. Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorg Chem. 2001; 29:156-163.

Equine Performance

1. Mourtzakis M, Graham TE. Glutamate ingestion and its effects at rest and during exercise in humans. Appl Physiol. 2002 Oct;93(4):1251-9. 2. Ehrlich, SD. (2009, June 20) Complementary Medicines. Glutamine. July 29, 2011; http://www.umm.edu/altmed/articles/glutamine-000307.htm. 3. Lacey JM and Wilmore DW. Is glutamine a conditionally essential amino acid? Nutrition Reviews. 2009; 48(8): 297-309. 4. Depeint F, et al. (2006). Mitochondrial function and toxicity: Role of the B vitamin family on mitochondrial energy metabolism. Chemico-Biological Interactions. 163(1-2):94-112. 5. Malouf, R and Grimley EJ. (2003). The effect of vitamin B6 on cognition. Cochrane Database Syst Rev. (4):CD004393. 6. Carver JD. Dietary nucleotides: effects on the immune and gastrointestinal systems. Acta Paediatr Suppl. 1999; 430:83-88. 7. Karren BJ, et al. Effect of selenium supplementation and plane of nutrition on mares and their foals: selenium concentrations and glutathione peroxidase. J anim Sci. 2010; 88(3):991-7. 8. De Moffarts B, et al. Effects of oral antioxidant supplementation on blood antioxidant status in trained thoroughbred horses. Vet J. 2005; 169(1):7-9. 9. Avellini L, et al. Effect of exercise training, selenium and vitamin E on some free radical scavengers in horses (Equus caballus). Comp Biochem Physiol B Biochem Mol Biol. 1999; 123(2):147-54. 10. Ducharme NG et al. Effect of a tart cherry juice blend on exercise-induced muscle damage in horses. Am J Vet Res. 2009; 70(6): 758-63. 11. Connolly DA, et al. Efficacy of a tart cherry juice blend in prevention the symptoms of muscle damage. Br J Sports Med. 2006; 40(8):679-83.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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About Standard Process

For more than 80 years, Standard Process has provided health care professionals with high-quality nutritional supplements with whole food ingredients. Our product formulas contain unique combinations of synergistic ingredients to provide specific nutritional support to the body. Standard Process meets the most demanding quality standards set by federal and state agencies, as well as by our own internal production and quality control departments.

Certified Organic Farming Our founder, Dr. Royal Lee, emphasized the importance of producing high-quality supplements with whole food ingredients. We are proud to be one of the few supplement manufacturers that can assure quality ingredients by continuing our tradition of growing many of our raw materials locally and organically.

Quality Begins With a Healthy Harvest The Kettle Moraine basin of Wisconsin contains nutrient-rich soil. It is here, on company-owned certified organic farmland, that we grow strong, vital plants for use in our supplements.We regularly grow the following crops: alfalfa, barley grass, beets, Brussels sprouts, buckwheat, kale, kidney beans, oats, pea vine, Spanish black radish, and sweet potatoes.

Organic Farming Methods Nature has provided the foundation, and we use organic farming practices to ensure that the quality of our farmland is maintained for years to come. In accordance with our organic certification, we follow strict guidelines to grow our crops, keeping detailed records of our farming practices. Our farmland is monitored annually by certifying agencies to ensure that only the approved farming practices are used. At Standard Process, we are involved from the moment a seed is planted through shipping the finished product to your door. Seeds There is zero tolerance in an organic system for genetic modification. On the Standard Process farm, we use certified organic seeds whenever they are available, whether they are purchased or saved from our own farm. Untreated conventional seed is an option but is considered only after a diligent search is conducted and it is determined that certified organic seed is not available. Irrigation Irrigation water is supplied from a naturally occurring artesian flowage below the farm’s surface. Weed Control Organic weed-control standards are strictly adhered to at the Standard Process farm. The main methods of weed management include: ▶▶Cultivating ▶▶Mowing ▶▶Hand weeding ▶▶Cover crops—used for weed prevention and as a source of nitrogen and organic matter ▶▶Crop flamer—used to eliminate the last flush of weeds before vegetable emergence ▶▶Crop rotation—an effective weed-control, insect-control, and disease-control strategy 38

Composting Standard Process utilizes composting, which is nature’s way of recycling, to increase fertility and soil health on the farm. Composting is the biological process of breaking up organic production waste from the farm’s press room into an extremely useful humus-like substance.

About Standard Process

Eco-Sensitive Processing The majority of biodegradable byproducts produced during manufacturing are returned to the fields in a monitored, land-spreading program. By doing this, we keep unnecessary wastes out of landfills and put nutrients back into the soil to benefit crops in the following years.

Environmental Buffers Our farm is surrounded on all sides by environmental buffers to minimize the impact of nonagricultural land and synthetic inputs from conventional farming practices.

Manufacturing Dr. Royal Lee, founder of Standard Process, said, “Whole foods are the best natural source of vitamins. The key to the highest quality is the manufacturing process.” Because preserving the whole food complex is a top priority when manufacturing our supplements, we base our formulas on Dr. Lee’s time-proven philosophies. Our manufacturing process, from raw materials to finished product, takes an average of six weeks. Throughout the process, raw materials are handled in a carefully controlled environment and continually tested for quality.

Exclusive Manufacturing Processes Each process is precision designed to preserve the nutrients in raw materials. Grinding Immediately after harvest, whole foods grown on our certified organic farmland, such as Brussels sprouts, are ground for further processing. Juice Extraction To capture the nutrients from raw materials such as buckwheat, alfalfa, and pea vine, the juice is pressed from the plants and separated from the pulp. The result is a concentrated product containing both fat- and water-soluble nutrients. Separation Process Selected animal tissues used to make our Protomorphogen™ and Cytosol™ extracts are ground to create a liquid slurry.The slurry is subjected to our exclusive multistep separation methods. All raw animal tissues are obtained exclusively from USDA-certified facilities. Low-Temperature, High-Vacuum Dryers Raw materials are dried in low-temperature, high-vacuum dryers to preserve nutrients. 39

We use isolated production suites for the following processes. These suites enhance cleanliness in the manufacturing area.

Quality Checks From Raw Ingredient to Final Product Supplier audits

Mixing Dried materials are measured and mixed with the utmost precision. Because of the variability in natural and organic ingredients, color, texture, and smell may vary from batch to batch. However, the basic formula remains constant, and quality is ensured by repeat testing. Binding and Processing Aids After mixing, our fluid bed granulator is used to add natural binding ingredients, such as honey and arabic gum, to the product batch for tableting.

Most raw materials

Loading dock

Mixing/ milling

Internal Audits

About Standard Process

Continuing the Process

Tablet/capsule preparation

Other processing aids we use include cellulose and calcium stearate. Cellulose is often used to give body to the powders. When needed, calcium stearate, derived from vegetable sources, is used to help product release from the tooling of the tablet and capsule machines. No artificial flavoring is ever used.

Tableting/ capsuling

Forms of Delivery

Continuous monitoring of label claims, including shelf life, and customer comments

Packaging

Identification Microorganism check Chemistry: supplier claims

Microorganism check Chemistry: label claims

Microorganism check Chemistry: label claims Gluten content

Microorganism check Prep lab (tablet hardness, capsule closure, weight)

Microorganism check Shelf-life samples

Powders In order to fill our powder formulas, Standard Process uses a volumetric filler. This system achieves very accurate fills and provides a highly consistent product from batch to batch. Tablets and Wafers The tablet presses used by Standard Process allow for high-volume production without sacrificing quality control in the manufacturing process. All of our finished tablets and wafers are routinely analyzed for content to ensure that label claims are accurate.

Packaging The veterinary products are sealed in green bottles. The color helps protect the food’s nutrients from damaging light, while the sealed bottle helps prevent product oxidation. Induction seals and neckbands protect against product tampering. The bottled product is then labeled and packaged in ecofriendly cardboard boxes providing easy storage, protection, and shipping. For ease of dispensing, a scoop holding ¹⁄8 or ½ teaspoon has been added to each box of the powdered canine formula, and a scoop holding ¼ cup is included in equine formulas.

Cleaning In between product runs, all of the equipment used in our manufacturing process is taken apart, cleaned, and sanitized. Adenosine triphosphate (ATP) testing is used to validate the effectiveness of the equipment-cleaning process. In addition, the surrounding production suite, including the floors, walls, and vent covers, is cleaned. Environmental Program In order to monitor the general level of plant hygiene, Standard Process has implemented an environmental monitoring program for the facility. This program allows for detection of any microorganism that may be found in the facility, including the drains. The program is twofold. It highlights the presence of any foodborne pathogen that may be in the facility and determines the source of these pathogens. Routine meetings between production and quality control are held to maintain the highest level of cleanliness throughout all areas of the facility. 40

Standard Process has always taken great pride in its quality control program. Since the good manufacturing practices (GMPs) for dietary supplements were published in 2007, many companies began to look at quality in the way that we at Standard Process have been doing for decades. Our team of scientists, composed of highly trained and degreed microbiologists and chemists, work meticulously to guarantee our customers receive the highest-quality products. Our quality control unit ensures our label claims are met and testing is performed after critical stages of production to confirm our products are free of bacterial contamination. Additionally, shelf-life studies are conducted on each product to make certain that label claims are met throughout the life of the product.

Testing Repeated testing on every batch throughout the manufacturing process enables us to ensure quality and safety of our products. On average, a product is tested six times. Every week our scientists in our full-scale quality control laboratory perform as many as 1,100 tests on raw materials, in-process product batches, and finished product. We use analytical methods that have been approved by nationally recognized evaluative bodies, including the Association of Analytical Communities (AOAC) and United States Pharmacopeia (USP).

About Standard Process

Quality Control

Laboratory Information Management System (LIMS) Standard Process’ quality control department has fully validated and implemented the Nexxis iLAB laboratory integrated management system (LIMS) by Labtronics. The system allows for a centralized storage location for all data analysis conducted by the laboratory. This implementation has improved data analysis by ensuring quality and accuracy of results, providing real-time data retrieval, preventing data errors, automating manual calculations, and allowing for lab data to be accessed throughout the facility.

Chemistry Standard Process chemists perform multiple assays to guarantee that our products meet or exceed label claims and to ensure the viability of the product through its “best used by” date. We use the following instrumentation in testing raw materials and final product mixes: High-Performance Liquid Chromatography (HPLC) Gas Chromatography (GC) Inductively Coupled Plasma (ICP) High-Performance Thin-Layer Chromatography (HPTLC) Fourier Transform Infrared Spectroscopy (FTIR) LECO ®

vitamins A, E, B6, B12, D; niacin; folic acid solvents minerals, heavy metals botanical identification raw material identification protein analyzer

The chemistry laboratory personnel also conduct wet chemistry tests for a variety of things, such as: vitamin C, vitamins B1 and B2, pepsin, bile salts, water activity, moisture, carotene, iodine, phosphorous, and chloride. The vast testing capability of the chemistry laboratory allows Standard Process to verify the identity, purity, and strength of our products and of the raw materials used in our products.

Microbiology Standard Process microbiologists perform pathogen testing on every product batch to ensure the products are safe to continue to the next stage of production. Testing is conducted on all facets of the manufacturing process, including raw materials, mixing, milling, tableting, capsuling, and packaging. Raw materials, in-process products, and final products are only released to the next stage of production by the quality control unit upon verification that the material or product has passed all testing requirements.

Farm Soil samples are taken annually to determine mineral and nutrient levels of the soil. No synthetic fertilizers or pesticides are ever used in the organic growing process. 41

About Standard Process

Research and Development Dr. Royal Lee believed in the value of scientifically researched supplements with whole food ingredients. He field tested, endorsed, and supported clinical evaluations of his unique nutritional supplements. Input from health care professionals enabled him to enhance and perfect the health benefits of Standard Process products.

Building for the Future Standard Process is dedicated to continuing Dr. Lee’s research and development practices by applying the latest technology and expertise to his founding principles.  We combine the evaluation of current scientific research and Dr. Lee’s insights and teachings with applied clinical research in our research and development department. Our research and development department consists of skilled, professionally trained scientists who work to provide a scientific basis for the safe and effective use of our supplements, herbs, and other natural products for health care professionals.

Types of Research The goal of our scientists is to gain a detailed understanding of the underlying biochemical components, physiological activities, and population health applications of supplements with whole food ingredients. Discovery Science Discovery science is conducted using powerful analytical techniques including high-pressure liquid chromatography, gas chromatography, and mass spectral detection to identify, quantify, and analyze key chemical markers within whole food ingredients. Using plants grown in experimental test plots at our farm, our scientists evaluate which plant varieties will survive and grow in our climate and determine appropriate harvest time to maximize nutrient content. Further experiments with multiple laboratory models such as mammalian cell culture, biochemical assays, and measurement of gene expression by real-time polymerase chain reaction (PCR) are used to document the biological activity of individual ingredients and finished products. We use this approach to expand our understanding of Standard Process materials and are always working to inform health care professionals, patients, and the scientific community about our findings through the publication of peerreviewed journal articles, presentations at international scientific conferences, and informational communications undertaken by Standard Process. Clinical Research Clinical research is primarily conducted through collaborative relationships with conventional and complementary research and educational institutions. This allows us to evaluate the effectiveness of new and existing whole food supplements in large populations of patients and seeks to establish relationships between supplements and improved health. By collaborating with experts, we can use clinical research to explore the impact of supplements with whole food ingredients on patients. The clinical research conducted by our research department allows us to continually evaluate the effectiveness of our products.

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What the ‘Best Used By’ Date Means The “best used by” information, located on all product boxes and on the shoulder of all product bottles, represents the date by which the product is best used by and the product code. The “best used by” date should not be viewed as an expiration date but as a guideline for when products are considered 100 percent potent. Products tend to lose potency over time but may still be considered effective after this date. Standard Process only guarantees product potency up until the “best used by” date. Products are continuously tested to determine their shelf life. This testing has shown that certain products tend to have shorter shelf lives, which is reflected in the “best used by” date.

How to Read the ‘Best Used By’ Information

Reading Labels

Reading Labels and the ‘Best Used By’ Code

In this example, the product is best used by July 2015. Product code numbers are used to determine when products are produced. In the example, the product code is L316. For example: L—Lot number Best Used By 3—Last number of the year it was produced (3 = Year 2013) 1—Batch number Date 7-15 L316 Code 6—Month it was produced (6 = June)

How to Read the Product Labels Below is an example of the different parts of our label and what they refer to.

2

Key

1. Principal display panel (PDP): This area displays product line, product name, product number, size, and suggested use (feline only).

3 1 4

5

2. Serving information 3. Ingredients: Ingredients contained within the product and with tableting aids (feline only) are listed in decreasing order of predominance.

6

4. Mineral and vitamin content: This nutrient information is required only if the product contains more than 2 percent of the daily value. 5. Dose schedule (canine only): Recommendations are based on body weight.

2 3

6. Bar code: Provides easier inventory control. A list of current bar codes can be found on our website.

1

6

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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References and Glossary

Primary Ingredient Cross Reference Use this quick reference to find the products that contain specific ingredients as one of their primary ingredients. Please reference the individual product description to see all of the ingredients in a certain product. Adrenal: Canine Adrenal Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Feline Cardiac Support, Feline Hepatic Support Adrenal Cytosol™ Extract: Canine Adrenal Support, Canine Dermal Support, Canine Immune System Support, Canine Whole Body Support, Feline Cardiac Support, Feline Immune System Support, Feline Renal Support, Feline Whole Body Support Adrenal PMG™ Extract: Canine Adrenal Support, Canine Dermal Support, Canine Enteric Support, Canine Immune System Support, Canine Thyroid Support, Canine Whole Body Support Alfalfa Juice: Canine Adrenal Support, Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Cardiac Support, Feline Enteric Support, Feline Hepatic Support, Feline Immune System Support, Feline Renal Support, Feline Whole Body Support Allantoin: Canine Adrenal Support, Canine Enteric Support, Canine Hepatic Support, Canine Renal Support, Feline Enteric Support, Feline Whole Body Support Antronex® Base: Canine Dermal Support, Canine Hepatic Support, Canine Whole Body Support, Feline Hepatic Support Arginex® Base (Extract of Rhizopus oryzae grown on Tillandsia usneoides and beet root): Canine Musculoskeletal Support, Canine Renal Support, Feline Hepatic Support, Feline Renal Support, Feline Whole Body Support

Brussels Sprouts: Equine GI Support, Equine Performance, Equine Immune Support Buckwheat: Canine Adrenal Support, Canine Cardiac Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Feline Cardiac Support, Feline Hepatic Support, Feline Immune System Support, Feline Renal Support, Feline Whole Body Support, Equine Metabolic Support, Equine GI Support, Equine Performance, Equine Immune Support Calcium Glycerophosphate: Canine Enteric Support, Canine Hepatic Support, Canine Musculoskeletal Support, Canine Thyroid Support Calcium Lactate: Canine Cardiac Support, Canine Dermal Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Thyroid Support, Canine Whole Body Support Carrot: Canine Adrenal Support, Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Enteric Support Cayenne: Equine Metabolic Support Chamomile: Equine GI Support

Beet Leaf Juice: Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Musculoskeletal Support, Feline Hepatic Support, Feline Renal Support, Feline Whole Body Support

Chlorophyll Extract: Canine Adrenal Support, Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Musculoskeletal Support, Canine Renal Support, Feline Enteric Support

Beet Root: Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Whole Body Support, Feline Hepatic Support, Feline Renal Support, Feline Whole Body Support

Choline Bitartrate: Canine Cardiac Support, Canine Hepatic Support, Canine Whole Body Support, Feline Hepatic Support, Feline Whole Body Support

Black Currant Juice: Canine Adrenal Support, Canine Dermal Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support Black Currant Seed Oil: Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support Bone Meal: Canine Dermal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Cardiac Support, Feline Hepatic Support, Feline Renal Support, Feline Whole Body Support Boswellia serrata (Boswellia): Canine Musculoskeletal Support 44

Bovine Bile Salts: Canine Dermal Support, Canine Enteric Support, Canine Immune System Support

Chondroitin Sulfate: Canine Flex Support, Equine Mobility Support Chromium: Equine Metabolic Support Cinnamon: Equine Metabolic Support, Equine Mobility Support Copper Liver Chelate: Canine Hepatic Support, Canine Whole Body Support, Feline Hepatic Support, Feline Immune System Support Crataegus oxyacantha (Hawthorn): Canine Cardiac Support, Feline Cardiac Support Duodenum: Canine Adrenal Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Thyroid Support, Feline Enteric Support, Feline Hepatic Support, Feline Renal Support

Eleutherococcus senticosus (Eleuthero): Canine Adrenal Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Thyroid Support, Feline Immune System Support Emblica officinalis (Indian Gooseberry): Canine Dermal Support, Feline Cardiac Support, Feline Hepatic Support, Feline Immune System Support, Feline Renal Support, Feline Whole Body Support Flax Meal: Equine Mobility Support Ginger: Canine Flex Support, Equine Mobility Support Glucosamine Sulfate: Canine Flex Support, Equine Mobility Support Glutamate: Equine Performance Green Tea: Equine Metabolic Support

Kidney: Canine Adrenal Support, Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Whole Body Support, Feline Cardiac Support, Feline Enteric Support, Feline Hepatic Support, Feline Immune System Support, Feline Renal Support, Feline Whole Body Support Kidney Bean Extract: Canine Renal Support, Canine Whole Body Support, Feline Renal Support, Feline Whole Body Support Kidney PMG™ Extract: Canine Renal Support, Canine Whole Body Support, Feline Hepatic Support, Feline Renal Support, Feline Whole Body Support L-carnitine: Canine Cardiac Support, Canine Whole Body Support, Feline Cardiac Support, Feline Whole Body Support

Heart PMG™ Extract: Canine Cardiac Support, Canine Hepatic Support, Canine Musculoskeletal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Cardiac Support, Feline Renal Support, Feline Whole Body Support

L-glutamine: Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Feline Enteric Support, Feline Hepatic Support, Feline Immune System Support, Feline Whole Body Support, Equine GI Support, Equine Immune, Equine Performance

Hypothalamus Cytosol™ Extract: Canine Whole Body Support, Feline Immune System Support

Licorice Root: Equine Metabolic Support

Hypothalamus PMG™ Extract: Canine Whole Body Support Inositol: Canine Cardiac Support, Canine Dermal Support, Canine Hepatic Support, Canine Whole Body Support, Feline Hepatic Support, Feline Whole Body Support Inulin: Equine GI Support Iron Liver Chelate: Canine Whole Body Support, Feline Hepatic Support, Feline Immune System Support Jejunum: Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Feline Enteric Support, Feline Immune System Support, Feline Whole Body Support Kale: Equine GI Support, Equine Performance, Equine Immune Support Kelp: Canine Adrenal Support, Canine Immune System Support, Canine Renal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Cardiac Support, Feline Immune System Support

References and Glossary

Brussels Sprouts

Liver: Canine Adrenal Support, Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Flex Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Cardiac Support, Feline Enteric Support, Feline Hepatic Support, Feline Immune System Support, Feline Renal Support, Feline Whole Body Support Liver PMG™ Extract: Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Whole Body Support, Feline Hepatic Support, Feline Whole Body Support Manganese Glycerophosphate: Canine Adrenal Support, Canine Renal Support, Canine Whole Body Support Mushroom: Canine Adrenal Support, Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Canine Whole Body Support, Equine Immune Support

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References and Glossary

Nutritional Yeast: Canine Adrenal Support, Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Renal Support, Canine Whole Body Support, Feline Cardiac Support, Feline Enteric Support, Feline Hepatic Support, Feline Whole Body Support Orchic Cytosol™ Extract: Canine Musculoskeletal Support, Canine Renal Support, Canine Whole Body Support, Feline Cardiac Support, Feline Immune System Support, Feline Whole Body Support Orchic Extract: Canine Adrenal Support, Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Thyroid Support Pancreas Cytosol™ Extract: Canine Cardiac Support, Canine Enteric Support, Canine Immune System Support Pea Vine Juice: Canine Adrenal Support, Canine Cardiac Support, Canine Enteric Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Cardiac Support, Feline Hepatic Support, Feline Immune System Support, Feline Renal Support, Feline Whole Body Support Pituitary PMG™ Extract: Canine Adrenal Support, Canine Enteric Support, Canine Hepatic Support, Canine Renal Support, Canine Whole Body Support, Feline Immune System Support Ribonucleic Acid: Canine Cardiac Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Feline Cardiac Support, Feline Immune System Support, Feline Renal Support Rice Bran: Canine Adrenal Support, Canine Cardiac Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Renal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Cardiac Support, Feline Enteric Support, Feline Hepatic Support, Feline Renal Support, Feline Whole Body Support Selenium: Equine Performance Silybum marianum (Milk Thistle): Canine Dermal Support, Canine Hepatic Support, Canine Whole Body Support, Feline Hepatic Support Soybean Lecithin: Canine Adrenal Support, Canine Musculoskeletal Support, Canine Thyroid Support, Canine Whole Body Support Spleen: Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Renal Support, Canine Whole Body Support, Feline Cardiac Support, Feline Enteric Support, Feline Hepatic Support, Feline Immune System Support, Feline Renal Support, Feline Whole Body Support

Stomach: Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Whole Body Support, Feline Enteric Support, Feline Hepatic Support Strombus gigas (Conch): Canine Dermal Support, Canine Hepatic Support, Canine Musculoskeletal Support, Canine Thyroid Support, Feline Enteric Support, Feline Hepatic Support, Feline Renal Support, Feline Whole Body Support Tart Cherry: Equine Performance Thymus Cytosol™ Extract: Canine Immune System Support, Canine Whole Body Support, Feline Immune System Support Thymus PMG™ Extract: Canine Immune System Support, Canine Whole Body Support Thyroid PMG™ Extract: Canine Adrenal Support, Canine Hepatic Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Immune System Support Tillandsia usneoides (Spanish Moss): Canine Cardiac Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Cardiac Support, Feline Renal Support Trachea: Canine Musculoskeletal Support, Canine Whole Body Support, Feline Whole Body Support Turmeric: Canine Flex Support, Equine Immune Support Vanadium: Equine Metabolic Support Veal Bone PMG™ Extract: Canine Adrenal Support, Canine Cardiac Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Whole Body Support, Feline Enteric Support, Feline Renal Support Wheat Germ: Canine Adrenal Support, Canine Cardiac Support, Canine Dermal Support, Canine Enteric Support, Canine Hepatic Support, Canine Immune System Support, Canine Musculoskeletal Support, Canine Thyroid Support, Canine Whole Body Support, Feline Enteric Support, Feline Hepatic Support, Feline Renal Support, Feline Whole Body Support Wheat Germ Oil: Canine Adrenal Support, Canine Cardiac Support, Canine Enteric Support, Canine Hepatic Support, Canine Musculoskeletal Support, Canine Renal Support, Canine Thyroid Support, Feline Cardiac Support, Feline Enteric Support, Feline Hepatic Support Zinc Liver Chelate: Canine Hepatic Support, Canine Immune System Support, Canine Whole Body Support, Feline Hepatic Support, Feline Immune System Support, Feline Whole Body Support

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Allantoin—A crystallizable substance derived from plants. Formed by the oxidation of uric acid.

Chondroitin sulfate—An important component of the extracellular matrix of connective tissue.

Bentonite (montmorillonite)—A natural colloidal, adsorbing clay that can bind substances present in the lumen of the digestive tract, allowing these substances to be eliminated with the fecal material.

Chromium—A blue-white metallic element shown to support insulin’s actions, which regulates the metabolism of glucose and other nutrients.

Betaine—A sweet, crystalline, quaternary ammonium salt found in beet juice. Can be used as a lipotropic factor or a gastric acidifier. Black currant juice—A source of anthocyanins with antioxidant properties. Black currant seed oil—A good source of omega-6 essential fatty acids, such as gamma-linoleic acid. Boswellia serrata (boswellia)—This herb helps maintain healthy joint tissue by maintaining the body’s normal inflammation response function. Bovine bile salts—A purified source of bovine bile salts in a powdered form. Supports the healthy metabolism and absorption of dietary fat.

Copper liver chelate—Provides an excellent source of copper. Copper is an essential trace mineral that is important for a wide range of biochemical processes. Crataegus oxyacantha (hawthorn)—Hawthorn is a wellknown heart and vascular tonic. Cytosol™ extract—Cytosol™ is the trademark owned and used by Standard Process Inc. as a brand name for extracts derived from the cytoplasm of the cell. They contain the materials such as enzymes, hormone precursors, and synergistic cofactors produced by the cell. These materials serve as the building blocks for cellular metabolic end products that are utilized by the cell itself or transported outside the cell.

Bromelain—Protein-digesting and milk-clotting enzyme generally found in pineapple fruit juice and stem tissue.

Defatted wheat germ—Wheat germ is noted for its dense nutritional content of the vitamin B complex and many important trace minerals essential for the full physiological activity of the associated vitamin complexes.

Brussels sprouts—Cruciferous vegetable that influences detoxification pathways.

Dicalcium phosphate—A calcium compound used in calcium therapy.

Buckwheat—A rich source of vitamin P (rutin), quercetin, and other bioflavonoids and minerals.

Eleutherococcus senticosus (eleuthero)—Eleuthero contains compounds that work to promote vitality, enhance immune system function, and support the body’s ability to adapt to temporary stress; its tonifying ability promotes physical and mental endurance.

Calcium glycerophosphate—A white crystalline powder that is soluble in cold water. A source of calcium. Calcium lactate—A source of calcium. (Not derived from a dairy product or source.) Carbamide powder—A food-grade urea. A source of nitrogen that promotes healthy cellular fluid levels.

Emblica officinalis (Indian gooseberry)—A source of bioflavonoids and vitamin C. Native to India, the plum-sized fruit is revered for its anti-aging and immune-enhancing properties.

Carthamus tinctorius (safflower)—The flower tops are diaphoretic, diuretic, and laxative. They also appear to have a supportive effect on the cardiovascular system.

Flax meal—Contains significant levels of omega-3 fatty acids, specifically alpha-linolenic acid (ALA), which has been implicated in reducing the inflammatory response.

Chamomile—This well-known perennial composite herb has a long history of traditional use as support for the stomach lining, complete digestive system, and immune system balance. It is also thought to act as a natural calmative that relaxes while still maintaining a positive energy level.

Ginger—A thickened pungent aromatic rhizome that contains a broad spectrum of bioactive compounds.

Chlorophyll extract—A fat-soluble extract from plant material that acts to support tissue health, maintenance, and regeneration. Chlorophyll is regarded as a natural gastrointestinal tract deodorant and cleanser.

References and Glossary

Glossary

Ginkgo biloba (ginkgo)—Ginkgo is known for a number of traditional benefits, including strengthening blood vessels, stabilizing cell membranes, and scavenging free radicals. It also supports healthy oxygen flow to the brain and peripheral areas of the body. Glucosamine sulfate—An important component of cartilage growth, maintenance, and repair.

Choline bitartrate—A vitamin of the B complex essential to liver function. 47

References and Glossary

Glutamate—An amino acid that generates energy and supports the excretion of excess/waste compounds from the body.

Licorice—An herb that helps stimulate cellular response. Known to promote healthy adrenal gland function and support the digestive and urinary tract systems.

Glycerophosphate—A salt of glycerophosphoric acid used as a dietary supplement.

Magnesium lactate—Source of magnesium. Magnesium plays an essential role as a cofactor, assisting enzymes in catalyzing many necessary reactions.

High-chromium yeast—A source of chromium. Chromium has been shown to improve glucose tolerance and immune response. High-selenium yeast—A source of selenium. Selenium is an essential trace element that has antioxidant activity. It is also believed to help maintain a healthy heart and joints. Inositol—A component of the B-vitamin complex. Inositol acts as an important catalyst in energy reactions that involve the metabolizing of some fats and carbohydrates. Inulin—A complex carbohydrate and soluble fiber. It is beneficial to the gut microflora and supports calcium and magnesium absorption. Inulin is found naturally in many common plants, especially chicory. Iron chelate—Provides an excellent source of iron. Iron is an important nutrient essential for a wide range of vital biological processes, including the synthesis of hemoglobin, and is also involved in the entire process of respiration, including oxygen and electron transport. Kale—Cruciferous vegetable that influences detoxification pathways Kelp (seaweed)—A good source of trace minerals. L-carnitine—Carnitine is required for transporting longchain fatty acids into the cells, which is essential to the conversion of fatty acids into energy for the cells, especially in heart muscle. L-glutamine—An amino acid used to make other amino acids, glucose, and glutathione. Used for energy by immune and intestinal cells.

Manganese glycerophosphate—Source of manganese, an essential trace mineral important for skeletal and cartilage formation. Manganese lactate—Source of manganese. A manganese salt derived from lactic acid. Manganese acts as a cofactor and catalyst in many enzymatic processes. Mushroom—Available in many varieties and has a long history of use for immune support in traditional Chinese medicine. Nutritional yeast (Saccharomyces cerevisiae)—Inactive yeast with high protein and B-vitamin content. Pea vine—An annual leguminous vine. Peas are a rich source of vitamin C; vitamin K; provitamin A carotenoids; and minerals, such as iron, potassium, phosphorus, and folacin. Perna canaliculus—Green-lipped mussel powder. A source of highly concentrated glycosaminoglycans, trace minerals, and fatty acids. Thought to improve joint flexibility. Protomorphogen™ extract—In the 1940s, Dr. Royal Lee pioneered a unique method of deriving extracts that contain what he called cell determinants from specific organs and glands for clinical use. He believed that these cell determinants functioned in cell regulation, maintenance, and interaction with tissue antibodies. It is clear both from the description of the extraction process and clinical use that these extracts differ from what is commonly referred to as “glandulars.” Furthermore, because these extracts have a distinct clinical application and effect, they should not be confused with glandulars, nor should they be referred to simply as “protomorphogens.” Rather, Protomorphogen™ is the trademark owned and used by Standard Process Inc. as a brand name assigned to these uniquely derived extracts. PMG™ is another trademark owned and used by Standard Process Inc. as another brand name for these extracts. Rhizopus oryzae—A mold grown on Tillandsia usneoides and beet root as a source of enzymes. Ribonucleic acid—Nucleic acid occurring in cell cytoplasm and the nucleolus, first isolated in plants but later found in animal cells.

Pea Vine

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Selenium—Part of the protection mechanisms within cells. It supports the metabolism of oxidation products within cells and also plays a role in thyroid hormone metabolism.

Botanical Name. . . . . . . . . . . . . Common Name

Common Name. . . . . . . . . . . . . Botanical Name

Boswellia serrata. . . . . . . . . . . . . boswellia

Ashwagandha, Indian ginseng. . . . Withania somnifera

Carthamus tinctorius . . . . . . . . . . safflower

Boswellia. . . . . . . . . . . . . . . . . . . Boswellia serrata

Crataegus oxyacantha . . . . . . . . . hawthorn

Dandelion root. . . . . . . . . . . . . . . Taraxacum officinale

Eleutherococcus senticosus . . . . . eleuthero

Eleuthero. . . . . . . . . . . . . . . . . . . Eleutherococcus senticosus

Emblica officinalis . . . . . . . . . . . . Indian gooseberry

Filamentous fungi. . . . . . . . . . . . . Rhizopus oryzae

Ginkgo biloba. . . . . . . . . . . . . . . . ginkgo

Ginkgo . . . . . . . . . . . . . . . . . . . . Ginkgo biloba

Rhizopus oryzae. . . . . . . . . . . . . . filamentous fungi

Hawthorn. . . . . . . . . . . . . . . . . . . Crataegus oxyacantha

Silybum marianum . . . . . . . . . . . milk thistle

Indian gooseberry. . . . . . . . . . . . . Emblica officinalis

Taraxacum officinale . . . . . . . . . . dandelion root

Milk thistle. . . . . . . . . . . . . . . . . . Silybum marianum

Tillandsia usneoides. . . . . . . . . . . Spanish moss

Safflower. . . . . . . . . . . . . . . . . . . Carthamus tinctorius

Withania somnifera . . . . . . . . . . . ashwagandha, Indian ginseng

Spanish moss . . . . . . . . . . . . . . . Tillandsia usneoides

Silybum marianum (milk thistle)—Contains flavanolignans (collectively known as silymarin), which are some of the most potent liver-protecting substances known. Stabilizes liver cell membrane against injury, regulates its permeability, assists in cellular regeneration, and scavenges for free radicals.

Tillandsia usneoides (Spanish moss)—A plant belonging to the pineapple family, grown in the southeastern coastal plain of the United States. It is a nonparasitic plant that is supported by another plant and has aerial roots exposed to the humid atmosphere.

Soybean lecithin—A rich source of lecithin, a precursor to choline. A substance that is crucial for proper central nervous system, liver, cardiovascular, and immune system health. A rich source of phospholipids. Spanish black radish—An excellent source of sulfur, which protects against free radicals and is also beneficial in the healthy functioning of the gastrointestinal tract. Strombus gigas (conch)—A sea mollusk with a large spiral shell. A good source of protein, amino acids, and trace minerals.

Turmeric—An Indian perennial herb of the ginger family. Contains many phytochemicals, some of which support the downregulation of inflammatory cytokines, displays antioxidant properties, and modulates a wide range of cellsignaling molecules. Vanadium—A grayish metallic element found combined in minerals that can mimic insulin’s actions. Wheat germ oil—One of the richest sources of the complete vitamin E complex. Vitamin E is beneficial in multiple metabolic processes.

Tart cherry—Historically used for activity-based inflammation response.

Withania somnifera (ashwagandha, Indian ginseng)— Studies indicate ashwagandha possesses antistress, antioxidant, immunomodulatory, hemopoietic, and cellular regeneration properties; it also encourages a healthy response to environmental stresses. It also appears to exert a positive influence on the endocrine, cardiopulmonary, and central nervous systems.

Thiamine (vitamin B1)—Essential for the normal metabolism of carbohydrates and fats.

Zinc liver chelate—Contains zinc that is bound to bovine liver to maintain healthy zinc levels.

Taraxacum officinale (dandelion)—Useful for its ability to stimulate the liver, as a diuretic, and for its cellular protection properties.

References and Glossary

Botanical and Common Name Reference

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Getting Started

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Client Education Materials We offer a variety of complimentary educational materials to share with your clients.Visit us online at standardprocess.com to view all available items. Examples

L4664 Whole Food Supplements for Pets Brochure

L4593 Equine Brochure

L4508 and L4509 Canine and Feline Formulas Overview Handouts

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