Prevention of Oxidative Stress Caused by Antitubercular Drugs Using Aqueous Extracts of Daucus carota and Moringa oleifera

International Journal of Scientific and Research Publications, Volume 3, Issue 10, October 2013 ISSN 2250-3153 1 Prevention of Oxidative Stress Caus...
Author: Edwina Caldwell
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International Journal of Scientific and Research Publications, Volume 3, Issue 10, October 2013 ISSN 2250-3153

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Prevention of Oxidative Stress Caused by Antitubercular Drugs Using Aqueous Extracts of Daucus carota and Moringa oleifera 1

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*Bello, B., 1Wudil, A.M. and 1Atiku, M.K.

Biochemistry Department, Bayero University Kano, P.M.B. 3011, Kano, Nigeria

ABSTRACT- The antioxidant effect of aqueous extracts of Daucus carota root and Moringa oleifera leaf were investigated in antitubercular drugs (isoniazid, INH and rifampicin, RMP) induced oxidative stress.The test control rats were administered with INH (27mg/kg) and RMP (54mg/kg) for 4 weeks to induce oxidative stress. Rats were pretreated with doses of 100mg/kg and 200mg/kg of aqueous extracts of Daucus carota and Moringa oleifera respectively for 4 weeks then INH and RMP were administered for another 4 weeks. Rats were also co-administered with 100mg/kg and 200mg/kg of the extracts plus INH and RMP for 4 weeks. The effect of the extracts on oxidative stress was determined by monitoring the serum malondialdehyde (MDA) concentration. Pretreatment and coadministration of Daucus carota and Moringa oleifera aqueous extracts significantly (P

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