PRELIMINARY SCIENTIFIC PROGRAM Thursday July 14th 13:30-17:30 SPECIAL WORKSHOP WS01 WORKSHOP ON COMMUNICATION OF RESEARCH RESULTS Chaired by: Michael J. Zigmond (Pittsburgh, USA) and Beth A. Fischer (Pittsburgh, USA) 16:00-17:30 SINS SPECIAL FEATURE FOUR ITALIAN NEUROSCIENTISTS 17:30-18:30 OPENING CEREMONY EDAB PRESIDENT’S LECTURE Fifty Years of IBRO Albert J. Aguayo (Montreal, Canada) IBRO PLENARY SESSION IBRO Past Presidents & Secretary Generals awarded by Carlos Belmonte (Alicante, Spain) & Pierre Magistretti (Lausanne, Switzerland) 18:30-19:30 OPENING PLENARY LECTURE PL1 Optical technologies for probing neural signals and systems Karl Deisseroth (Stanford, USA) 19:30-20:30 WELCOME RECEPTION

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Friday July 15th 08:30-09:30 PLENARY LECTURE PL2 Regulation and function of adult neurogenesis in the hippocampal formation Fred H. Gage (La Jolla, USA) 09:30-11:30 SYMPOSIUM S01 INTEGRATION OF NEW NEURONS IN THE ADULT BRAIN: LESSONS FOR BRAIN REPAIR Chaired by: Alejandro Fabian Schinder (Buenos Aires, Argentina) Temporal expression of neurotrophin receptors regulates newborn neuron integration into hippocampal circuits Marco Canossa (Genoa, Italy) Local network activity controls maturation and functional integration of adult-born hippocampal neurons Alejandro Fabian Schinder (Buenos Aires, Argentina) Molecular development of projection neuron types and building of local microcircuitry in the cerebral cortex Paola Arlotta (Cambridge, USA) Voluntary versus forced metamorphosis of astroglia into neurons Benedikt Berninger (Munich, Germany) 09:30-11:30 SYMPOSIUM S02 MOLECULAR AND CELLULAR DETERMINANTS OF NEURON/GLIA SPECIFICATION Chaired by: Flávia Carvalho Alcantara Gomes (Rio de Janeiro, Brazil) Glial cells generating neurons: molecular and cellular mechanisms Magdalena Gotz (Munich, Germany) Radial glial polarity and its contributions to neuronal migration in cerebral cortex Eva Anton (Chapel Hill, USA) Intra- and extra-cellular factors regulating neural stem cell differentiation during brain development Kinichi Nakashima (Ikoma, Japan) Cellular determinants of radial glia commitment and astrocyte differentiation: implications for synapse formation Flávia Carvalho Alcantara Gomes (Rio de Janeiro, Brazil) 09:30-11:30 SYMPOSIUM S03 ELIMINATION OF AMYLOID FROM THE AGEING AND ALZHEIMER DISEASE BRAIN: UNCLOGGING THE DAM Chaired by: Roxana Octavia Carare (Southampton, UK)

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The prion-like aspect of cerebral amyloidosis Yvonne Eisele (Tubingen, Germany) The role of perivascular drainage in ageing Roxana Octavia Carare (Southampton, UK) Immunotherapy in Alzheimer's Disease James Nicoll (Southampton, UK) Dissolving the fibrils and targeting the phagocytes of the Alzheimer's brain JoAnne McLaurin (Toronto, Canada) 09:30-11:30 SYMPOSIUM S04 BLINDSIGHT IN ACTION: RESIDUAL VISUOMOTOR FUNCTIONS AFTER LESIONS OF PRIMARY VISUAL CORTEX Chaired by: Carlo Alberto Marzi (Verona, Italy) Goal-directed grasping and obstacle avoidance after lesions of V1 Melvyn Goodale (London, Canada) Disynaptic routes from superior colliculus to dorsal stream visual areas Ed Callaway (La Jolla, USA) Sensory-motor blindsight in the physical and social world Beatrice de Gelder (Tilburg, The Netherlands) Is blindsight mediated by the lesioned or the intact hemisphere? Carlo Alberto Marzi (Verona, Italy) 09:30-11:30 SYMPOSIUM S05 COMPUTATIONAL STUDY OF MEMORY INFORMATION PROCESSING: DATA ANALYSIS AND MODELING OF CORTICO-HIPPOCAMPAL INTERACTION Chaired by: Masami Tatsuno (Lethbridge, Canada) Cortical reactivation of recent neuronal activity patterns in the subsequent sleep is related to hippocampal activity Francesco Battaglia (Amsterdam, The Netherlands) Memory reactivation during slow-wave sleep and REM sleep Masami Tatsuno (Lethbridge, Canada) Role of the cognitive map during navigation planning: from place cells to direction cells – a computational model Colin Molter (Lausanne, Switzerland) Dynamical representation of environments in the brain Yoko Yamaguchi (Wako City, Japan) 11:30-14:30 POSTER SESSION

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12:30-14:00 SPECIAL EVENT SE01 IPSEN FOUNDATION PRIZE AWARDS 12:30-14:00 SPECIAL EVENT SE02 MOLECULAR AND SYSTEMS NEUROBIOLOGY IN DEVELOPMENT AND DISEASE: CONTRIBUTIONS FROM IBRO ALUMNI WORLDWIDE Chaired by: Susan J. Sara (Paris, France) and Pierre Magistretti (Lausanne, Switzerland) Herbal compounds in the treatment of drug abuse: Fruit essential oil of Cuminum cyminum attenuates morphine-induced conditioned place preference Abbas Haghparast (Teheran, Iran) Herbal compounds in the treatment of psychiatric disorders:The aqueous extract of leaves of Piliostigma reticulatum possesses anxiolytic and antipyretic activity in mice Elisabeth Ngo Bum (Ngaoundere, Cameroon) In search of organizing principles during synapse elimination: Correlation between motoneuron size and position at spinal cord and motor unit innervation patterns Cristina Guatimosim (Belo Horizonte, Brazil) Molecular architecture of the hippocampal dendritic spine Bence Racz (Budapest, Hungary) 12:30-14:00 SPECIAL EVENT SE03 SINS-SDN JOINT MINISYMPOSIUM 1 14:30-16:00 WORKSHOP W01 BERGMANN GLIA CELLS IN SYNAPTIC FUNCTION Chaired by: Arturo Ortega (Mexico City, Mexico) Insights into the biological roles of Bergmann glia by transcriptional profiling Gabriel Corfas (Boston, USA) Plasticity of neuron to Bergmann glial cell transmission Tomas Bellamy (Cambridge, UK) The role of Bergmann glia for purinergic modulation of the cerebellar network Joaquim Deitmer (Kaiserslautern, Germany) Translational control of Bergmann glia/neuronal coupling Arturo Ortega (P, Mexico City, Mexico) 14:30-16:00 WORKSHOP W02 NEXT GENERATION SEQUENCING STRATEGIES IN NEUROGENETICS Chaired by: Guy A. Rouleau (Montreal, Canada) Personal genome analyses to elucidate the molecular pathogenesis of neurodegenerative diseases Shoji Tsuji (Tokyo, Japan)

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Using next generation sequencing to identify candidate genes for neurogenetic disorders Iscia Lopez-Cendes (Campinas, Brazil) Is exome sequencing the answer for definitive molecular diagnosis of the many rare hereditary neuropathies? Garth Nicholson (Sydney, Australia) Next sequencing generation in rare monogenic disorders: An experience in spinocerebellar degenerations Alexis Brice (Paris, France) 14:30-16:00 WORKSHOP W03 BASAL GANGLIA CONTROL OF SLEEP-WAKE REGULATION Chaired by: Yoshihiro Urade (Osaka, Japan) Sources and actions of adenosine in the basal ganglia Bertil Fredholm (Stockholm, Sweden) The role of adenosine A2A receptors in the nucleus accumbens for sleep-wake regulation Michael Lazarus (Osaka, Japan) Dopamine D2 receptors in the basal ganglia are essential in the maintenance of wakefulness Zhi-Li Huang (Shanghai, China) Basal ganglia control of sleep-wake behavior and cortical activation Jun Lu (Boston, USA) 14:30-16:00 WORKSHOP W04 GENETIC MOUSE MODELS TO UNDERSTAND SCHIZOPHRENIA Chaired by: Raul R. Gainetdinov (Genoa, Italy) Mouse models for genes associated with risk for psychosis: a platform for identification of novel antipsychotic targets Colm O'Tuathaigh (Dublin, Ireland) DISC1 mouse models of schizophrenia: a comparative analysis and future developments Mikhail Pletnikov (Baltimore, USA) Role of glutamatergic neurotransmission in the mechanism of action of antipsychotics Fabio Fumagalli (Milan, Italy) Animal models to identify therapeutic mechanisms of antipsychotics Jean-Martin Beaulieu (Quebec, Canada) 14:30-16:00 WORKSHOP W05 ACTIVITY-DEPENDENT TRAFFICKING OF NMDA AND KAINATE RECEPTORS IN SYNAPTIC PLASTICITY Chaired by: R. Suzanne Zukin (New York, USA)

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Regulation of NMDA receptor trafficking by palmitoylation Richard L. Huganir (Baltimore, USA) SNAP25 is a target of PKC phosphorylation critical to NMDA receptor trafficking R. Suzanne Zukin (P, New York, USA) A role for SNAP25 in kainate receptor internalization and synaptic plasticity Juan Lerma (Alicante, Spain) Bidirectional plasticity expressed by NMDA receptors at hippocampal mossy fiber synapses Pablo E. Castillo (New York, USA) 16:00-17:30 WORKSHOP W06 REMODELLING OF NEURAL EXTRACELLULAR MATRIX IN HEALTH AND DISEASE Chaired by: Alexander Dityatev (Genoa, Italy) Extracellular matrix of perineuronal nets and neuroplasticity Alexander Dityatev (Genoa, Italy) Matrix metalloproteinase MMP-9 in synaptic plasticity, elipeptogenesis and drug addiction Leszek Kaczmarek (Warsaw, Poland) The neurotrypsin/agrin system – its roles in mental retardation and activity-dependent structural plasticity in the CNS Peter Sonderegger (Zurich, Switzerland) Plasminogen activating system in post-injury recovery and epileptogenesis Asla Pitkanen (Kuopio, Finland) 16:00-17:30 WORKSHOP W07 NEUROBIOLOGICAL BASIS OF EMERGING THERAPIES IN DRUG ADDICTION Chaired by: Gaetano Di Chiara (Cagliari, Italy) The dopamine hypothesis of drug addiction Marco Diana (Sassari, Italy) The human dopamine system in addiction Diana Martinez (New York, USA) Interaction between 5-HT and DA in relation to the treatment of psychostimulant dependence Valentina Valentini (Cagliari, Italy) Forgetting to be addicted by brain stimulation: from animal models to human application Abraham Zangen (Rehovot, Israel) 16:00-17:30 WORKSHOP W08 HABILITATION OF HEARING IN THE 21ST CENTURY Chaired by: Edwin W. Rubel (Seattle, USA) Challenges for hair cell regeneration as a therapy for deafness Andrew Forge (London, UK)

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Novel therapies for noise-induced hearing loss based on the actions of insulin-like growth factor 1 and transforming growth factor β2 Isabel Varela (Madrid, Spain) Targeting cell cycle molecules and tumor suppressors for therapeutic benefit: implications in sensory hair cell regeneration and survival Ulla Pirvola (Helsinki, Finland) Can we restore lost hearing? Development and regeneration of the inner ear Neil Segil (Los Angeles, USA) 16:00-17:30 WORKSHOP W09 EPILEPTOGENESIS: MECHANISMS AND PREVENTION Chaired by: Christophe Bernard (Marseille, France) Epigenetic factor mediate HCN1 channelopathy Christophe Bernard (Marseille, France) T-type clacium channel upregulation as a pro-epileptogenic factor Albert Becker (Bonn, Germany) Preventing epileptogenesis: anti-inflammatory strategy Annamaria Vezzani (Milan, Italy) Preventing epileptogenesis: growth factors strategy Michele Simonato (Ferrara, Italy) 16:00-17:30 WORKSHOP W10 THE PERILS AND PITFALLS OF TRANSLATING COMPLEX BRAIN RESEARCH RESULTS FOR PUBLIC UNDERSTANDING Chaired by: Linda Mayes (New Haven, USA) Neurologic heuristics and artistic whimsy: the cerebral cartography of Wilder Penfield Peter Jeffrey Snyder (Providence, USA) Neurosurgical evolution and the media Dennis Spencer (New Haven, USA) Asymmetries of the brain: the right and the wrong Giorgio Vallortigara (Rovereto, Italy) The translation of complex stories in neuroscience into “Take Home Messages”: a general summary and synthesis Linda Mayes (New Haven, USA) 17:30-18:30 PLENARY LECTURE PL3 Motivational value in the human brain Ray J. Dolan (London, UK)

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18:30-19:30 SPECIAL WORKSHOP SW02 YOUNG INVESTIGATOR VISITING PROGRAM WORKSHOP Chaired by: Micaela Morelli (Cagliari, Italy) 18:30-19:30 SPECIAL WORKSHOP SW03 EVENING DISCUSSION WITH PLENARY SPEAKERS I Using pre- and post-doctoral training to prepare for a successful professional career. Chaired by: Michael J. Zigmond (Pittsburgh, USA) and Beth A. Fischer (Pittsburgh, USA)

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Saturday July 16th 08:30-09:30 PLENARY LECTURE PL4 Local control of synaptic function Erin M. Schuman (Frankfurt, Germany) 09:30-11:30 SYMPOSIUM S06 PUTTING DENDRITES BACK INTO THE BRAIN: NEW APPROACHES FOR STUDYING DENDRITIC FUNCTION IN VIVO Chaired by: Greg Stuart (Canberra, Australia) Synaptic activation of dendrites and spines in sensory cortex neurons in vivo Arthur Konnerth (Munich, Germany) Two-photon imaging of Purkinje cell dendritic activity in vivo Kazuo Kitamura (Tokyo, Japan) Exploring dendritic activity in vivo from different angles - what do we learn about cortical networks Matthew Larkum (Bern, Switzerland) Dendritic synaptic integration in mouse visual cortex in vivo Michael Hausser (London, UK) 09:30-11:30 SYMPOSIUM S07 SIGNAL TRANSDUCTION AND CELL BIOLOGY OF GROWTH CONE GUIDANCE Chaired by: Yimin Zou (La Jolla, USA) Cell polarity signaling and growth cone guidance Yimin Zou (La Jolla, USA) ADF/Cofilin-mediated actin turnover directs neuritogenesis in the developing mammalian brain Frank Bradke (Martinsried, Germany) Membrane dynamics in growth cone guidance Hiroyuki Kamiguchi (Wako City, Japan) Molecular mechanisms of axon branching and its role in neural circuit formation Dietmar Schmucker (Leuven, Belgium) 09:30-11:30 SYMPOSIUM S08 SUBCELLULAR LOCALIZATION AND FUNCTION OF VOLTAGE-GATED ION CHANNELS Chaired by: Matthew Nolan (Edinburgh, UK) Polarized subcellular distribution of voltage-gated Na+ and K+ channels in the central nervous system Andrea Lorincz (Budapest, Hungary)

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Compartmentalized processing and storage in pyramidal neurons Jeffery Magee (Ashburn, USA) HCN channel regulation of cortical glutamatergic synaptic transmission Mala Shah (London, UK) Kv1.1 in neuronal excitability and synaptic transmission: insights from channelopathies Dimitri Kullmann (London, UK) 09:30-11:30 SYMPOSIUM S09 PRION BIOLOGY AND PATHOLOGY Chaired by: Rafael Linden (Rio de Janeiro, Brazil) Reggie/flotillin and prion protein in axon growth and adherens junction formation Claudia Stuermer (Konstanz, Germany) Interaction of mammalian prion proteins with nucleic acids and glycosaminoglycans Jerson Silva (Rio de Janeiro, Brazil) The role of the N-terminal region of prion protein in prion disease Suehiro Sakaguchi (Tokushima, Japan) The role of neuroinflammation in the pathogenesis of prion disease Hugh Perry (Southampton, UK) 09:30-11:30 SYMPOSIUM S10 THE ENDOGENOUS OPIOID SYSTEMS IN PSYCHIATRIC AND NEUROLOGICAL DISEASES Chaired by: Brigitte Kieffer (Illkirch, France) Mu and delta opioid receptors: opposing roles Brigitte Kieffer (Illkirch, France) Opioids and the coordination of stress response Andreas Zimmer (Bonn, Germany) A role for p38 MAPK in kappa opioid receptor-dependent dysphoria Michael Bruchas (St. Louis, USA) The dynorphin/KOP system in temporal lobe epilepsy Christoph Schwarzer (Innsbruck, Austria) 11:30-14:30 POSTER SESSION 12:30-14:00 SPECIAL EVENT SE04 IBRO SYMPOSIUM: CONTRIBUTION OF IBRO TO WORLD NEUROSCIENCE

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12:30-14:00 SPECIAL EVENT SE05 FINE-SCALE MAPPING OF THE DEVELOPING MOUSE AND HUMAN BRAIN Chaired by: John Hohmann (Seattle, USA) A new approach to mammalian brain ontologies based on ontogeny Luis Puelles (Murcia, Spain) Spatial mapping of gene expression in developing mouse brain Salvador Martinez (Alicante, Spain) High resolution reference atlases in human brain Allan Jones (Seattle, USA) Mapping of gene expression across human development John Hohmann (Seattle, USA) 12:30-14:00 SPECIAL EVENT SE06 SINS-SDN JOINT MINISYMPOSIUM 2 14:30-16:30 WORKSHOP W11 STEM CELLS FOR THE TREATMENT OF SPINAL CORD INJURY: ARE WE THERE YET? Chaired by: Eva Sykova (Prague, Czech Republic) Stem cells and biomaterials for the treatment of spinal cord injury Eva Sykova (Prague, Czech Republic) Use of neural stem cells for repair of the injured spinal cord Michael G. Fehlings (Toronto, Canada) Transplantation of human bone marrow-derived cells induces axonal sprouting and improves functional outcome after axonal damage to the spinal cord Jeffery D. Kocsis (New Haven, USA) Cell integration and axon growth in the spinal cord James W. Fawcett (Cambridge, UK) 14:30-16:30 WORKSHOP W12 THE DIVERSE ACTIONS OF ESTROGENS IN HOMEOSTATIC REGULATION Chaired by: Shaila Mani (Houston, USA) Estrogen receptor beta regulation of stress responses Robert Handa (Phoenix, USA) Estrogens and neuroprotection mechanisms in cholinergic neurons Istvan Abraham (Dunedin, New Zealand) Estrogen regulation of hippocampal synaptogenesis Gabriele Rune (Hamburg, Germany)

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Novel actions of estrogen receptors in nociception Paul Micevych (Los Angeles, USA) 14:30-16:30 WORKSHOP W13 ODORANTS, RECEPTORS AND GLOMERULI Chaired by: Peter Mombaerts (Frankfurt, Germany) Phragrance and pharmacology: a functional approach to mammalian odorant receptors Stuart Firestein (New York, USA) Olfactory transduction in the mouse: amplification by calcium-activated chloride channels Anna Menini (Trieste, Italy) Protomaps in the development of the mouse olfactory system Charles Greer (New Haven, USA) Olfaction targeted Peter Mombaerts (Frankfurt, Germany) 14:30-16:30 WORKSHOP W14 STRUCTURAL PLASTICITY AND MEMORY Chaired by: Paul Frankland (Toronto, Canada) Neocortical rewiring and memory storage Gerald Finnerty (London, UK) Structural plasticity of the long-term consolidation of memories in the cortex Paul Frankland (Toronto, Canada) Bidirectional remodeling of hippocampal and cortical circuits during extinction of remote conditioned fear Martine Ammassari-Teule (Rome, Italy) Integration of adult born hippocampal neurons into behaviorally relevant networks and their role in information processing Victor Ramirez-Amaya (Mexico City, Mexico) 14:30-16:30 WORKSHOP W15 TRANSCRIPTOMIC AND GENOMIC APPROACHES TO NEUROLOGICAL DISORDERS Chaired by: Yuri Bozzi (Trento, Italy) Systems-level functional genomic investigations of the CNS transcriptome Daniel Geschwind (Los Angeles, USA) Gene expression profiling of forebrain areas in a mouse model of autism Yuri Bozzi (Trento, Italy) mRNA and miRNA transcriptomes of epileptic tolerance David Henshall (Dublin, Ireland)

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Transcriptome analysis of dopaminergic cells: implications for Parkinson's disease Stefano Giustincich (Trieste, Italy) 16:00-17:30 WORKSHOP W16 ENGINEERING RECEPTORS TO INVESTIGATE THE IN VIVO CELL SIGNALING CASCADES THET UNDERLIE PHYSIOLOGY, BEHAVIOUR, AND NEUROLOGICAL DISORDERS Chaired by: John Neumaier (Seattle, USA) Probing striatal function using pathway-selective viral vectors and engineered receptors John Neumaier (Seattle, USA) Control of Gi/o signaling and neuronal activity by light to modulate spinal cord and motor function Stefan Herlitze (Bochum, Germany) Activation of astrocytic GPCRs in vivo leads to a striking behavioral phenotype Ken McCarthy (Chapel Hill, USA) 5-HT4 RASSL and neurodegenerative diseases Joel Bockaert (Montpellier, France) 16:00-17:30 WORKSHOP W17 NICOTINIC MECHANISMS UNDERLYING REWARD, EMOTION AND COGNITION Chaired by: Sigismund Huck (Vienna, Austria) Nicotinic receptors and attention performance: focus on receptor desensitization Huibert D. Mansvelder (Amsterdam, The Netherlands) Endogenous cholinergic inputs and the modulation of cortico-amygdala transmission Lorna W. Role (Stony Brook, USA) Alpha 5 nicotinic receptors and the mechanisms of drug withdrawal Mariella De Biasi (Houston, USA) Nicotinic receptors and synaptic plasticity in the meso-accumbens dopamine system Daniel S. McGehee (Chicago, USA) 16:00-17:30 WORKSHOP W18 PHYSIOLOGICAL ROLES AND ANTIPARKINSONIAN POTENTIAL OF METABOTROPIC GLUTAMATE RECEPTORS IN THE BASAL GANGLIA MOTOR CIRCUIT Chaired by: P. Jeffrey Conn (Nashville, USA) Physiological roles and antiparkinsonian potential of mGluRs in the basal ganglia motor circuit P Jeffrey Conn (Nashville, USA) Role of metabotropic glutamate receptors in Parkinsonian motor impairment in the rat Marianne Amalric (Marseille, France)

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Neuroprotective role of metabotropic glutamate receptors in experimental parkinsonism Giuseppe Battaglia (Pozzilli, Italy) Group I and group III mGluRs: potential targets for antiparkinsonian and neuroprotective therapies in MPTP-treated monkeys Yoland Smith (Atlanta, USA) 16:00-17:30 WORKSHOP W19 STRESS-INDUCED CHANGES IN CORTICO-LIMBIC STRUCTURES Chaired by: Andrew Holmes (Bethesda, USA) Effects of stress on neuronal structure and function in medial prefrontal cortex Cara Wellman (Bloomington, USA) Interactions between the amygdala and the prefrontal cortex under stressful conditions Mouna Maroun (Haifa, Israel) Synaptic changes in prefronto-limbic circuits induced by neonatal adverse socio-emotional experience Katharina Braun (Magdeburg, Germany) Impact of stress and ageing on hippocampal corticosterone and memory retrieval in mice Daniel Beracochea (Talence, France) 16:00-17:30 WORKSHOP W20 COMMUNICATING NEUROSCIENCE TO THE PUBLIC Chaired by: Colin Blakemore (Oxford, UK) No time to be ethical? Judy Illes (Vancouver, Canada) What matters in developing countries Rajesh Kalaria (Newcastle, UK) What matters in Europe Piergiorgio Strata (Turin, Italy) Brain research in the media Elaine Snell (London, UK) 17:30-18:30 PLENARY LECTURE PL5 The neurobiology of pain and its control Allan I. Basbaum (San Francisco, USA) 18:30-19:30 SPECIAL WORKSHOP SW04 AFRICAN RESEARCH WORKSHOP Chaired by: Abdul Mohammed (Stockholm, Sweden)

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18:30-19:30 SPECIAL WORKSHOP SW05 EVENING DISCUSSION WITH PLENARY SPEAKERS II How to start your own lab Chaired by: Michael J. Zigmond (Pittsburgh, USA) and Beth A. Fischer (Pittsburgh, USA)

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Sunday July 17th 08:30-09:30 PLENARY LECTURE PL6 Visualizing circuits in the developing visual system Joshua R. Sanes (Harvard, USA) 09:30-11:30 SYMPOSIUM S11 CHROMATIN REMODELING IN NEURAL DEVELOPMENT Chaired by: Victor Tarabykin (Berlin, Germany) Understanding the words of chromatin remodeling Gerald R. Crabtree (Stanford, USA) A novel epigenetic mechanism in neurons Antonella Riccio (London, UK) The role of histone modifying enzymes in motor neuron development Soo-Kyung Lee (Houston, Texas) Control of neocortical development by Satb proteins Victor Tarabykin (Berlin, Germany) 09:30-11:30 SYMPOSIUM S12 GLIAL AND NEURONAL CONTROL OF BRAIN BLOOD FLOW IN HEALTH AND DISEASE Chaired by: Serge Charpak (Paris, France) The regulation of brain blood flow by synaptic activity in vivo Martin Lauritzen (Glostrup, Denmark) Astrocyte modulation of cerebral blood vessels in health and disease Brian MacVicar (Vancouver, Canada) Glial regulation of blood flow in the normal and diabetic retina Eric Newman (Minneapolis, USA) Regulation of capillary diameter by pericytes in health and disease David Attwell (London, UK) 09:30-11:30 SYMPOSIUM S13 NEW ROLES FOR MELANOPSIN PHOTOPIGMENT IN NON-VISUAL AND VISUAL FUNCTIONS Chaired by: Howard Cooper (Bron, France) Light and the human circadian timing system Claude Gronfier (Bron, France) Melanopsin input to visual structures of the brain in the mouse Robert J. Lucas (Manchester, UK)

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Short wavelength light modulation of cognitive and emotional brain function in humans Gilles Vandewalle (Liege, Belgium) Use of ectopically expressed Melanopsin to restore vision in blind animals Satchidananda Panda (La Jolla, USA) 09:30-11:30 SYMPOSIUM S14 MENTAL AND PHYSICAL ACTIVITY AS MODULATORS OF BRAIN FUNCTION AND DISEASE Chaired by: Anthony Hannan (Melbourne, Australia) Brain and environment Lamberto Maffei (Pisa, Italy) Regulation and function of adult hippocampal neurogenesis: the role of exercise Henriette van Praag (Baltimore, USA) Unraveling the role of genes and environment in cognitive dysfunction Jess Nithianantharajah (Cambridge, UK) Preventive and curative effects of environmental enrichment on drug addiction Marcello Solinas (Poitiers, France) 09:30-11:30 SYMPOSIUM S15 STRESS, PLASTICITY & DRUG-SEEKING SPONSORED BY THE BRITISH JOURNAL OF PHARMACOLOGY Chaired by: Andrew Lawrence (Victoria, Australia) Stress due to maternal separation induces changes in the brain plasticity of dams and pups Giovanni Biggio (Cagliari, Italy) The effect of drug exposure on learning-related plasticity in the striatum and decision-making Bernard Balleine (Sydney, Australia) The role of neuronal nicotinic acetylcholine receptors in the development of alcohol and nicotine use disorders Selena Bartlett (San Francisco, USA) New anti-relapse drugs: findings from preclinical and translational studies Rainer Spanagel (Mannheim, Germany) 12:00-14:30 POSTER SESSION 12:30-13:30 SPECIAL EVENT SE07 THE VOYAGE INTO THE BRAIN OF PATIENT H.M. - THE ANATOMICAL EXAMINATION OF A NOTABLE CASE OF AMNESIA Presented by: Jacopo Annese (San Diego, USA)

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12:30-14:00 SPECIAL EVENT SE08 SFN SYMPOSIUM ON PUBLISHING MISCONDUCT 12:30-14:00 SPECIAL EVENT SE09 SINS-SDN JOINT MINISYMPOSIUM 3 14:30-16:00 WORKSHOP W21 BUILDING CEREBELLAR CIRCUITS: FROM NEURONAL SPECIFICATION TO SYNAPSE FORMATION Chaired by: Constantino Sotelo (Alicante, Spain) Patterning of cerebellar neurogenesis as revealed through analysis of cerebellar malformations in humans and mice Kathleen Millen (Chicago, USA) The genesis of cerebellar GABAergic neurons Ferdinando Rossi (Turin, Italy) Molecular control of neuronal migration in the cerebellar system Alain Chedotal (Paris, France) Molecular mechanisms of synaptic specificity in cerebellar circuits Peter Scheiffele (Basel, Switzerland) 14:30-16:00 WORKSHOP W22 NEURAL MECHANISMS UNDERLYING SPATIAL STABILITY Chaired by: David Burr (Florence, Italy) Saccadic suppression from the pulvinar pathway Robert Wurtz (Bethesda, USA) The role of oculomotor proprioception in spatial computations Michael Goldberg (New York, USA) Space encoding during fast eye movements Frank Bremmer (Marburg, Germany) Spatio-temporal plasticity of receptive fields during saccades Concetta Morrone (Pisa, Italy) 14:30-16:00 WORKSHOP W23 BDNF AND THE CONTROL OF THE TRANSLATIONAL MACHINERY IN DENDRITES Chaired by: Enrico Tongiorgi (Trieste, Italy) BDNF-induced changes in the proteome of dendrites: protein synthesis vs. protein degradation Carlos Duarte (Coimbra, Portugal)

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BDNF and the translational control of long-term potentiation Clive Bramham (Bergen, Norway) Regulation of miRNAs-mediated synaptic plasticity by BDNF Simon Arthur (Dundee, UK) Diversity in the regulation of BDNF splice variants translation Enrico Tongiorgi (Trieste, Italy) 14:30-16:00 WORKSHOP W24 PRION PROTEIN IN INTRACELLULAR AND INTERCELLULAR SIGNALLING IN THE BRAIN Chaired by: Marco Prado (London, Canada) Imaging prions: the site of pathological conversion and mechanism of spreading Chiara Zurzolo (Paris, France) LRP1-prion protein (PrPC) interactions as controllers of amyloid processing by neurons Roger Morris (London, UK) Copper dependent regulation of NMDA receptor by cellular prion protein – a role in Alzheimer’s disease Gerald Zamponi (Calgary, Canada) Regulation of cellular signaling: Prion protein on the move Marco Prado (London, Canada) 14:30-16:00 WORKSHOP W25 ADVANCES IN OPTICAL IMAGING OF BRAIN FUNCTION Chaired by: Gian Michele Ratto (Pisa, Italy) and Giorgio Carmignoto (Padova, Italy) Targeted patch clamp recordings from fine dendrites Thomas Nevian (Bern, Switzerland) STED microscopy to study macromolecular architectures at synapses Stephan J. Sigrist (Berlin, Germany) High resolution fluorescence imaging of optically cleared mouse brain tissue Gunter Giese (Heidelberg, Germany) Chloride and pH imaging in vivo using a GFP-based sensor Daniele Arosio (Trento, Italy) 16:00-17:30 WORKSHOP W26 ASTROCYTES IN PHYSIOLOGY AND PATOHOLOGY Chaired by: Michael VL Bennett (New York, USA) Endocannabinoid-mediated astrocyte-neuron signalling Alfonso Araque (Madrid, Spain)

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Normal and pathological astrocyte-oligondendrocyte coupling Luis C. Barrio (Madrid, Spain) Cholinergic signalling in astrocyte-neuron communication Gertrudis Perea (Cambridge, USA) Pannexin and connexin hemichannels in spinal cord inflammation Michael VL Bennett (New York, USA) 16:00-17:30 WORKSHOP W27 TEMPORAL STRUCTURE OF SPATIAL MEMORY: ATTRACTOR DYNAMICS OF HIPPOCAMPAL SPATIAL PROCESSING IN HEALTH AND SCHIZOPHRENIA Chaired by: Alessandro Treves (Trieste, Italy) Constructing a sense of place - the role of cue detection and cue integration Kate Jeffery (London, UK) Memories as hippocampal attractor states and their competition disclosed by teleportation Karel Jezek (Prague, Czech Republic) Neural correlates of cognitive control and schizophrenia-related disorganization in hippocampus Andre A. Fenton (Brooklyn, USA) Instability in attractor neural network dynamics and schizophrenia Edmund T. Rolls (Oxford, UK) 16:00-17:30 WORKSHOP W28 STRESS AT THE SYNAPSE. HOW BEHAVIORAL STRESS AND CORTICOSTEROIDS MODIFY SYNAPTIC TRANSMISSION AND PLASTICITY Chaired by: Maurizio Popoli (Milan, Italy) Metaplasticity of corticosteroid actions in the synapse Marian Joels (Utrecht, The Netherlands) Imaging the interplay of stress hormone and glutamate receptor at the single molecule level Laurent Groc (Bordeaux, France) Action of stress on presynaptic release of glutamate and modulation by antidepressant agents Maurizio Popoli (Milan, Italy) Synaptic and local circuit plasticity in the dentate gyrus. Potential relevance to traumatic memories Ziv Ardi (Haifa, Israel)

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16:00-17:30 WORKSHOP W29 IMMUNE CELL ENTRY AND FUNCTION WITHIN THE CNS: NEW MECHANISMS AND THERAPEUTIC OPPORTUNITIES Chaired by: Robyn Klein (St. Louis, USA) From immune surveillance to autoimmune disease: how effector T cells invade the brain Alexander Fluegel (Martinsried, Germany) Lymphocytes and loss of blood-brain barrier polarity during CNS inflammation Robyn Klein (St. Louis, USA) Extracellular adenosine triggers lymphocyte entry into the CNS during experimental autoimmune encephalomyelitis by regulating chemokine and adhesion molecule expression in the brain Margaret Bynoe (Ithaca, USA) A role for mucins in leukocyte trafficking in neurological diseases Gabriela Constantin (Verona, Italy) 16:00-17:30 WORKSHOP W30 NEURAL MECHANISMS OF RESPIRATORY RHYTHM GENERATION Chaired by: Fulvia Bongianni (Florence, Italy) Multiple oscillators for respiratory pattern formation Ana Abdala (Bristol, UK) Differential contribution of pacemaker neurons to respiratory rhythm generation Fernando Peña (Mexico City, Mexico) Synaptically activated burst-generating conductances in respiratory rhythm generation in the mammalian preBötzinger Complex Christopher A. Del Negro (Williamsburg, USA) Neurotransmitters and ionic mechanisms within the respiratory network of the lamprey Donatella Mutolo (Florence, Italy) 17:30-18:30 PLENARY LECTURE PL7 Molecular genetics of neurodegenerative dementias Christine van Broeckhoven (Antwerpen, Belgium) 18:30-19:30 SPECIAL WORKSHOP SW06 EVENING DISCUSSION WITH PLENARY SPEAKERS III Selecting creative research questions Chaired by: Michael J. Zigmond (Pittsburgh, USA) and Beth A. Fischer (Pittsburgh, USA)

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Monday July 18th 08:30-09:30 PLENARY LECTURE PL8 Defining the neuronal circuitry of fear Andreas Lüthi (Basel, Switzerland) 09:30-11:30 SYMPOSIUM S16 SYNAPTIC AND NETWORK PLASTICITY IN DEVELOPMENT AND LEARNING Chaired by: Ying-Shing Chan (Hong Kong, China) A role of endocannabinoids in development and plasticity of inhibitory circuits in the visual cortex Tadaharu Tsumoto (Wako City, Japan) The role of nitric oxide and GluR1 in experience-dependent plasticity in the somatosensory cortex Kevin Fox (Cardiff, UK) Unsilencing glutamatergic synapses switches on the vestibular circuit for spatial recognition Ying-Shing Chan (Hong Kong, China) Fear conditioning and synaptic plasticity in the amygdala network Pankaj Sah (Brisbane, Australia) 09:30-11:30 SYMPOSIUM S17 REGULATION OF PRESYNAPTIC CALCIUM CHANNEL ACTIVITY Chaired by: Gary Stephens (Reading, UK) Regulation of presynaptic calcium channels and short-term synaptic plasticity William Catterall (Seattle, USA) Differential effects of presynaptic calcium channel subtypes in control of synaptic transmission Richard Tsien (Stanford, USA) Spatial and temporal regulation of calcium channels Sumiko Mochida (Tokyo, Japan) Regulation of calcium channel activity by auxiliary alpha2delta subunits Annette Dolphin (London, UK) 09:30-11:30 SYMPOSIUM S18 THE ROLE OF SLEEP IN LEARNING AND MEMORY FORMATION: FROM MOLECULAR MECHANISMS TO COGNITIVE FUNCTION Chaired by: Debora Hipolide (Sao Paulo, Brazil) and Peter Meerlo (Groningen, The Netherlands) Sleep-related brain oscillations and memory consolidation Susan Sara (Paris, France)

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The molecular and cellular effects of sleep deprivation on hippocampal function Ted Abel (Philadelphia, USA) Sleep deprivation effects on learning and memory: the role of glucocorticoids Paula Tiba (Sao Paulo, Brazil) Consequences of mild sleep disruption: changes in regional brain activity and learning strategy Peter Meerlo (P, Groningen, The Netherlands) 09:30-11:30 SYMPOSIUM S19 MOTOR NEURONS: FROM DEVELOPMENT TO DISEASE Chaired by: Angelo Poletti (Milan, Italy) and Caterina Bendotti (Milan, Italy) From neuronal precursors to motorneuronal cells. A promise for understanding and counteracting disease. Georg Haase (Marseille, France) Induction of mutant proteins clearance in Amyotrophic Lateral Sclerosis and SpinoBulbar Muscular Atrophy Angelo Poletti (Milan, Italy) Toxicity mediated by a sumoylated glutamate transporter c-terminus fragment: an unconventional role for EAAT2 in motor neuron degeneration in ALS Davide Trotti (Philadelphia, USA) Axonal transport in motor neurons: from in vitro screens to real time in vivo assays Giampietro Schiavo (London, UK) 09:30-11:30 SYMPOSIUM S20 SYNAPTIC PROTEIN NETWORKS IN NEUROLOGICAL AND PSYCHIATRIC DISEASES Chaired by: Michela Matteoli (Milan, Italy) Synaptic gene networks in attention and cognition disorder Mattijs Verhage (Amsterdam, The Netherlands) Modulation of calcium dynamics by SNAP-25, a synaptic protein involved in different psychiatric disorders Michela Matteoli (Milan, Italy) Synaptic proteins and autism spectrum disorders Nils Brose (Gottingen, Germany) mRNA metabolism and synaptic dysfunctions: insights from the Fragile X Syndrome Claudia Bagni (Leuven, Belgium) 12:00-14:30 POSTER SESSION

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12:30-14:00 SPECIAL EVENT SE10 CARE/IBRO SYMPOSIUM ON ANIMAL CARE Chaired by: Roberto Caminiti (Rome, Italy) and Sharon Juliano (Bethesda, USA) 12:30-14:00 SPECIAL EVENT SE11 SINS-SDN JOINT MINISYMPOSIUM 3 14:30-16:00 WORKSHOP W31 NEUROTRANSMITTER TRANSPORTERS IN SYNAPTIC HOMEOSTASIS Chaired by: Vania Prado (London, Canada) Role of plasma membrane transporters in the control of monoamine Marc Caron (Durham, USA) Keeping up with acetylcholine: how vesicular storage regulates transmission Vania Prado (London, Canada) Glycine transporters: regulators of inhibitory and excitatory synaptic transmission Heihrich Betz (Frankfurt, Germany) VGLUT3 : synergizing serotoninergic and cholinergic transmission Salah El Mestikawy (Paris, France) 14:30-16:00 WORKSHOP W32 PROGRAMMING BY STRESSFUL AND ADVERSE EVENTS IN ADOLESCENCE OF ADULT STRESS REACTIVITY, COGNITION AND EMOTIONS Chaired by: Seema Bhatnagar (Philadelphia, USA) Lasting cognitive deficits after social instability stress in adolescence in male and female rats Cheryl McCormick (St Catharines, Canada) Sex specific effects of adolescent isolation on stress-regulatory neural substrates in adulthood Seema Bhatnagar (Philadelphia, USA) Differential impact of juvenile stress and corticosterone in juvenility and in adulthood in male and female rats Gal Richter-Levin (Haifa, Israel) Gene – environment interaction during adolescence shapes adult disease vulnerability Mathias Schmidt (Munich, Germany) 14:30-16:00 WORKSHOP W33 IMITATION IN MONKEYS: BEHAVIORAL AND NEURAL UNDERPINNINGS Chaired by: Martine Meunier (Bron, France) Imitation in newborn macaques: EEG correlates Pier Francesco Ferrari (Parma, Italy)

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Imitation in newborn macaques: effect of neonatal amygdala lesions Jocelyne Bachevalier (Atlanta, USA) Learning from self and others in adult rhesus macaques: comparison to humans Elisabetta Monfardini (Bron, France) Learning from self and others in adult rhesus macaques: neuronal correlates in the prefrontal cortex Abdelouahed Belmalih (Marseille, France) 14:30-16:00 WORKSHOP W34 CANNABINOID RECEPTOR SIGNALING AND MODULATION OF MONOAMINERGIC CIRCUITS: IMPLICATIONS FOR BEHAVIOR Chaired by: Elisabeth Van Bockstaele (Philadelphia, USA) New pespectives in cannabinoid signaling Ken Mackie (Bloomington, USA) Cannabinoid modulation of noradrenergic circuits Elisabeth Van Bockstaele (Philadelphia, USA) Cannabinoids and dopamine: implications for psychiatric disorders Eleni Tzavara (Paris, France) Endocannabinoid signaling: roles in neurodegeneration and schizophrenia Andrea Giuffrida (San Antonio, USA) 14:30-16:00 WORKSHOP W35 HOW TO PROPERLY USE ANIMALS IN RESEARCH: CONSIDERATION OF LEVELS OF PAIN, GENETIC BACKGROUND, TRANSGENICS, AND BEHAVIOR Chaired by: Sharon Juliano (Bethesda, USA) and Silvina Diaz (Paris, France) Do animals experience pain in the same way as humans? Paul Flecknell (Newcastle, UK) Genetic background problems in the analysis of cognitive and neuronal changes in genetically modified mice Hans-Peter Lipp (Zurich, Switzerland) How to use and charactize transgenic animals Fernando Benavides (Smithville, USA) Behavioral measures and animal models in cognitive and behavioral neuroscience Amy Starosciak (Bethesda, USA)

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16:00-17:30 WORKSHOP W36 IONIC TRANSPORTERS AND IONIC CHANNELS AS NEW MOLECULAR TARGETS IN STROKE INTERVENTION Chaired by: Lucio Annunziato (Naples, Italy) The Na+/H+ exchanger: A target for therapeutic intervention in cerebral ischemia Dandan Sun (Madison, USA) Na+/Ca2+ exchanger gene products: Molecular targets for the identification of new therapeutic strategies in cerebral ischemia Lucio Annunziato (Naples, Italy) Molecular participants in mitochondrial cell death channel formation during neuronal ischemia Elizabeth A. Jonas (New haven, USA) Role of TRPM7 in ischemic CNS injury John F. MacDonald (Toronto, Ontario) 16:00-17:30 WORKSHOP W37 ADVANCED FUNCTIONAL ANALYSIS OF CEREBELLAR CIRCUITS Chaired by: Egidio D’Angelo (Pavia, Italy) New technologies for the illumination of cerebellar function Thomas Knopfel (Wako City, Japan) Role of mGluR1/TRPC3 cerebellar function: from dendritic spines to behavior Jana Hartmann (Munich, Germany) Probing the function of cerebellar Golgi and Lugaro cells in vivo Ingrid Van Welie (London, UK) Signal analysis of multi electrode chronic recordings in the cerebellar cortex and nuclei in freely moving animals Dana Cohen (Ramat Gan, Israel) 16:00-17:30 WORKSHOP W38 SPATIOTEMPORAL PROFILES OF CORTICAL PROCESSING: A VIEW FROM OPTICAL IMAGING STUDIES IN AWAKE, BEHAVING NONHUMAN PRIMATES Chaired by: Anna Roe (Nashville, USA) Simultaneous spatio-temporal imaging of blood-oxygenation and neurophysiological signals Amir Shmuel (Montreal, Canada) Representing motion on V1 surface Frederic Chavane (Marseille, France) Inter-areal cortical binding patterns in the macaque monkey Hamutal Slovin (Ramat Gan, Israel)

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Spatiotemporal patterns of somatosensory activation Anna Roe (Nashville, USA) 16:00-17:30 WORKSHOP W39 NEUROBIOLOGY OF NEGLECTED AFRICAN DISEASES Chaired by: Krister Kristensson (Stockholm, Sweden) African Trypanosomes and the blood-brain barrier: From neuropathogenesis to search for diagnostic biomarkers Willias Masocha (Kuwait City, Kuwait) Brain injury in cerebral malaria: Integrating clinical, biochemical, and brain imaging studies to assess pathogenesis Richard Idro (Kampala, Uganda) Molecular epidemiology of konzo - an environmentally trigerred ALS-like syndrome associated with cyanogenic exposure Desire Tshala-Katumbay (Portland, USA) Khat: a widely used natural amphetamine in Africa Nilesh B. Patel (P, Nairobi, Kenya) 16:00-17:30 WORKSHOP W40 NOVEL GENETIC AND PHARMACOLOGICAL TOOLS PROVIDE NEW INSIGHTS INTO ROLES OF MUSCARINIC ACETYLCHOLINE RECEPTOR SUBTYPES FOR TREATMENT OF CNS DISORDERS Chaired by: Carrie K. Jones (Nashville, USA) Molecular mechanisms of allosterism at muscarinic receptors: Implications for CNS treatments Arthur Christopoulos (Melbourne, Australia) Structural determinants and functional effects of novel M1 allosteric activators provide novel insights for treatment of CNS disorders Chris Langmead (Welwyn Garden City, UK) Novel M1, M4, and M5 allosteric modulators for the treatment of psychosis and enhancement of cognition. Carrie K. Jones (Nashville, USA) M1 allosteric modulation as a potential therapeutic approach for Alzheimer’s Disease Michelle M Nicolle (Winston-Salem, USA) 17:30-18:30 CLOSING PLENARY LECTURE PL9 Useful signals from motor cortex Andrew B. Schwartz (Pittsburgh, USA)

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