UMass Center for Clinical & Translational Science 3rd Annual Research Retreat May 22, 2012 Hoagland-Pincus Conference Center, Shrewsbury, MA

Poster Presentations 1. Tantalum versus Titanium Acetabular Shells in Young Active THR Patients: A Radiostereometric Analysis (RSA) Study David Ayersa Marie Walcott, a Benjamin Snyder,a Michelle Aubin,a Jacob Drew,a Peyton Hays,a Michelle Aubin,a Mark Eskander,a David Ayers,a Henrik Malchau,b Charles Bragdonb a Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA; bMassachusetts General Hospital, Boston, MA 2. Can a detailed neurological exam improve prediction of extubation success in neurocritically ill patients? Sanam Baghshomali, MD1; Nathanael Slater, DO2; Raphael Carandang, MD1,3; Cynthia Ouillette, RN1; Wiley Hall, MD1,3; Susanne Muehlschlegel, MD, MPH1,2,3 Departments of 1Neurology (Division of Neurocritical Care), 2Anesthesia/Critical Care and 3Surgery 3. Serum microRNA-122 and miR-155 as biomarkers of liver injury and inflammation in models of acute and chronic liver disease Shashi Bala, Jan Petrasek, Shiv Mundkur, Donna Catalano, Jeanine Ward, Ivan Levin, Hawau Alao, Karen Kodys and Gyongyi Szabo University of Massachusetts Medical School, Worcester, MA-01605 4. A Mixed-Methods Study To Characterize Pharmaceutical Marketing in the Nursing Home Setting: OffLabel Use of Atypical Antipsychotics Camilla B. Benedicto, MPH1, Jennifer L. Donovan, PharmD2,3, Terry S. Field, DSc2, Jerry H. Gurwitz, MD2, Sarah Foy, BA2, Leslie R. Harrold, MD, MPH2, Abir O. Kanaan, PharmD2,3, Celeste A. Lemay, RN, MPH2, Kathleen M. Mazor, EdD2, Jennifer Tjia, MD, MSCE2, Sruthi Valluri, BS2, and Becky A. Briesacher, PhD2 1 Clinical and Population Health Research Doctoral Program, Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA 01655; 2Meyers Primary Care Institute, a joint endeavor of Fallon Community Health Plan, Reliant Medical Group and University of Massachusetts Medical School, Worcester, MA 01605; 3Department of Pharmacy Practice, Massachusetts College of Pharmacy and Health Sciences, Worcester, MA 01608 5. Gene Expression and Profiling of Human Islet Cell Subtypes David M. Blodgett, Susanne Pechhold, David M. Harlan University of Massachusetts Medical School, Department of Medicine, Diabetes Division

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6. Genetic determinants of cerebral edema in severe traumatic brain injury: A pilot study of the role of CACNA1 and AQP4 gene mutations Raphael A. Carandang MD, Susanne Muehlschlegel MD MPH, Wiley R. Hall MD, Cynthia Ouillette RN, Robert H. Brown Jr. MD D Phil, University of Massachusetts Medical School, Department of Neurology 7. Foregut Surgery in the Modern Era: A National Survey Zeling Chau M.D.1, Jillian Smith M.D.1, Elan Witkowski M.D.1, Liza Ragulin-Coyne M.D.1, Tara S. Kent M.D.2, Jennifer Tseng M.D. 1,2 1 University of Massachusetts Medical School, Department of Surgery, Surgical Outcomes Analysis & Research (SOAR); 2Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 8. Understanding the mechanisms of IGF2 gene regulation in hepatocellular carcinoma cells Amalene Cooper-Morgan, Natalia Naumova, Amartya Sanyal, Bryan Lajoie, Job Dekker and Brian C. Lewis University of Massachusetts Medical School: Program in Gene Function and Expression 9. Increased oxidative capacity of circulating polymorphonuclear neutrophils (PMNs) in non-diabetic NASH patients Timea Csak, Karen Kodys, Angela Dolganiuc, Dora Lippai, Michal Ganz, Chidima Okoli, Christopher Marshall, Gyongyi Szabo University of Massachusetts Medical School, Dept. of Medicine 10. Surveillance of Smokeless Tobacco Products Sold in Massachusetts (1997-2010) Doris Cullen1, MA; Kevin Kane2, MS; Lois Keithly1 PhD; Thomas Land1 PhD; Mark Paskowsky1, MS; Wenjun Li2, PhD 1 Massachusetts Department of Public Health, Tobacco Control Program; 2University of Massachusetts Medical School 11. Health Links: Who Acts as a Source of Health Information in a Social Network? Sarah L. Cutrona MD, MPH1,5; Sarah M. Greene2, MPH; Andrew E. Williams3, PhD; Douglas W. Roblin, PhD4; Joann L. Wagner, MSW5; Bridget Gaglio, PhD6; Paul K. J. Han, MD, MPH7; Kathleen M. Mazor, EdD1,5,8,9 1 University of Massachusetts Medical School, Worcester, MA; 2Group Health Research Institute, Seattle, WA; 3 Kaiser Permanente, Honolulu, HI; 4Kaiser Permanente, Atlanta, GA; 5Meyers Primary Care Institute, Worcester, MA; 6Mid-Atlantic Permanente Research Institute/Kaiser Permanente Mid-Atlantic States, Rockville, MD; 7Center for Outcomes Research and Evaluation, Portland, ME; 8Reliant Medical Group, Worcester, MA; 9Fallon Community Health Plan, Worcester, MA 12. International trends in pancreatic cancer incidence and mortality rates Wilfredo E. De Jesus-Monge, MD, MSc1, Bruce A. Barton, PhD2 1 Program in Gene Function and Expression, 1,2Memorial Cancer Center of Excellence, 1,2Center for Clinical and Translational Science, 2Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 13. Disrupted Resting-State Functional Connectivity in Medication-free Women with Postpartum Depression

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Kristina M. Deligiannidis, MD1, Elif M. Sikoglu, PhD2, Anthony J. Rothschild, MD1*, Constance M. Moore, PhD2* 1 Center for Psychopharmacologic Research & Treatment, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA; 2Center for Comparative Neuroimaging, University of Massachusetts Medical School, Worcester, MA; * equal contribution 14. Using bootstrap to compare the validity of PRO measures in discriminating among CKD patients Nina Deng, John E. Ware Jr. University of Massachusetts Medical School, Department of Quantitative Health Sciences 15. Mood Disorders and Trauma - What are the Associations? Yael Dvir M.D., Michael Hill B.S, Steven M Hodge M.A., Jean A Frazier M.D. University of Massachusetts Medical School, Community Health Link 16. Obstetric Interventions: Assessment of Differential Practices by Race/Ethnicity Joyce Edmonds, RN, MPH, PhD1, Revital Yehezkel MD2, Tiffany A. Moore Simas, MD, MPH, Med2, Xun Liao, MS2 1 University of Massachusetts Boston College of Nursing and Health Sciences; 2University of Massachusetts Medical School/UMass Memorial Medical Center 17. Comparison of Radiation Exposure During Thoracolumbar Fusion Using Fluoroscopic Guidance versus Anatomic Placement of Pedicle Screws Natalie Egge MD; Jeffrey Lange MD; Christian DiPaola MD; Anthony Lapinsky MD; Patrick Connolly MD; Jason Eck DO, MS University of Massachusetts Department of Orthopedic Surgery, Spine Division 18. Predictors of Improved Pain, Quality of Life, and Physical Function after Surgical Treatment of Lumbar Spinal Stenosis Natalie Egge MD; Anthony Lapinsky MD; Daniel Mandell BS; Jason Eck DO, MS; Christian DiPaola MD; Jeffrey Lange MD; Patrick Connolly MD; Patricia Franklin MD University of Massachusetts Department of Orthopedic Surgery, Spine Division 19. The Varus Knee Reveals Differential Expression Patterns of miRNAs in Spared vs. Non-spared Compartments 1 Fanning, P J; 1Ayers B; 1Walcott, M E; 2Stein G S; 1Ayers, D A; 2Lian J B University of Massachusetts Medical School, Depts. of 1Orthopedics and 2Cell Biology, Worcester, MA 20. Etiology of Experimental Osteoarthritis: Early Events and Potential Clinical Implications 1,2 Fanning PJ, 1Silva JA, 1Marvin J, 1Basil K, 1Walcott, ME; 1,2Ayers, DC University of Massachusetts Medical School, Depts. of 1Orthopedics and 2Cell Biology, Worcester, MA 21. Novel paths to antifungal therapeutics Ahmed Fazly1, Charu Jain3, Reeta Prusty Rao3, Paul D. Kaufman1,2 1 Gene Function and Expression, 2Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA; 3Worcester Polytechnic Institute, Department of Biology and Biotechnology, Worcester, MA

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22. Technological Resources and Personnel Costs Required to Implement an Automated Alert System for Primary Care Physicians When Patients Transition from Hospitals to Home Terry S. Field1, 2, DSc; Lawrence Garber2, MD; Shawn J. Gagne2, BA; Jennifer Tjia1, 2, MD; MSCE; Peggy Preusse2, RN; Jennifer L. Donovan1, 2, 3, PharmD, RPh; Abir O. Kanaan1, 2, 3, PharmD, RPh; Jerry H. Gurwitz1, 2 , MD 1 University of Massachusetts Medical School, 2Meyers Primary Care Institute – a joint endeavor of the University of Massachusetts Medical School, Reliant Medical Group, and Fallon Community Health Plan, 3 Massachusetts College of Pharmacy and Health Sciences 23. Factors Associated With Ordering Laboratory Monitoring Of High-Risk Medications Shira Fischer1, AB, Candidate for MD/PhD; Terry S. Field1, 2, DSc; Daniel Peterson2, MS; George Reed1, PhD; Jerry H. Gurwitz1, 2, MD; Jennifer Tjia1, 2, MD, MSCE 1 University of Massachusetts Medical School, 2Meyers Primary Care Institute – a joint endeavor of the University of Massachusetts Medical School, Reliant Medical Group, and Fallon Community Health Plan 24. Patient Adherence to Laboratory Tests to Monitor Medication Therapy: A Mixed-Methods Study Shira Fischer1, AB; Jennifer Tjia1, 2, MD, MSCE; Shawn J. Gagne2, BA; Kathleen Mazor1, 2, EdD; Peggy Preusse2, RN; George Reed1, PhD; Daniel Peterson2, MS; Jerry H. Gurwitz1, 2, MD; Terry S. Field1, 2, DSc 1 University of Massachusetts Medical School, 2Meyers Primary Care Institute – a joint endeavor of the University of Massachusetts Medical School, Reliant Medical Group, and Fallon Community Health Plan 25. FORCE-TJR: Innovative design for a national TJR comparative effectiveness research database. Patricia D. Franklin1; Jeroan Allison2, MD MS; Wenjun Li3, PhD; Leslie Harrold4, MD; Bruce Barton2, PhD; Benjamin Snyder1, MD MS; Milagros Rosal3, PhD; Norm Weissman2, PhD; John Ware, PhD2, David C. Ayers1, MD UMass Medical School departments of: 1Orthopedics and Physical Rehabilitation, 2Quantitative Health Sciences, 3Preventive and Behavioral Medicine, 4Rheumatology 26. Importance of clinically-refined medical and musculoskeletal co-morbidities in registries that evaluate patient-reported outcomes following TKR. Patricia D. Franklin1; Wenjun Li3, PhD; Carol Otis, PhD; Benjamin Snyder1, MD MS; Milagros Rosal3, PhD; David C. Ayers1, MD UMass Medical School departments of: 1Orthopedics and Physical Rehabilitation, 2Preventive and Behavioral Medicine, 3Arcadia University 27. rAAV9 airway delivery results in effective knockdown of mutant alpha 1-antitrypsin in the liver while upregulating wildtype alpha 1-antitrypsin in the lung Alisha Gruntman1, Christian Mueller1, Qiushi Tang1, Lina Song1, James M. Wilson2, Terence Flotte1, Maria P. Limberis2 1 Pediatrics and Gene Therapy Center, UMass Medical School, Worcester, MA, United States, 01605 2Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 28. The Iddm14 gene is Tcrbv-13S1A1: Prevention of Autoimmune Diabetes in the Rat with an AlleleSpecific Depleting Antibody That Recognizes the Vβ13a T Cell Receptor Beta Chain Michael Habib, Ryan Eberwine, Zhijun Liu, Thomas Herrmann, Dale Greiner, Laura Cort, Elizabeth Blankenhorn and John P. Mordes Worcester, MA, Würzburg, Germany, and Philadelphia, PA

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29. Eat Walk Sleep for Health: Primary Prevention in a Refugee Community Heather-Lyn Haley PhD1, Meredith Walsh MPH RN2, Nang Maung PhD3, Clara Savage EdD4, Suzanne Cashman ScD5 1 UMass Medical School Dept of Family Medicine and Community Health; 2UMass Worcester Graduate School of Nursing; 3UMass Worcester Graduate School of Biomedical Sciences; 4Common Pathways Community Health Network Area Coalition; 5UMass Medical School Dept of Family Medicine and Community Health 30. Gout Knowledge, Beliefs and Treatment Practices in a National Sample of US Primary Care Providers Leslie R. Harrold1, Kathy M. Mazor 2, Amarie Negron1, Jessica Ogarek2, Cassie Firneno2, Robert A. Yood3 1 Medicine, University of Massachusetts Medical School, 2Meyers Primary Care Institute, 3Reliant Medical Group, Worcester, MA 31. Development of an Electrowetting Valve in Capillary-Driven Microfluidic Biosensor for Nucleic Acid Detection Fei He, Tiphaine Mérian, Julie M. Goddard, Sam R.Nugen University of Massachusetts Amherst, MA 32. Occult cervical spinal dural arteriovenous fistula masquerading as acute spinal cord ischemia Saef Izzy, Bilal Hameed MD, Chutima Saipetch MD, Eugene Lin MD, David Paydarfar MD University of Massachusetts, Department of Neurology 33. Molecular imaging of the bioeffects of β-amyloid and metal ions on live human neuroblastoma cells: internalization, subcellular localization and induction of ROS Yong Jiao, Yi Zhang, Maolin Guo Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 34. Cost-Utility of Routine Endometrial Evaluation Prior to Le Fort Colpocleisis Padma Kandadai1 MD; Michael Flynn1 MD, MHS; Susan Zweizig2 MD; Danielle Patterson1 MD, MSc 1 University of Massachusetts Memorial Medical Center, Department of Obstetrics and Gynecology, Division of Urogynecology and Reconstructive Pelvic Surgery; 2University of Massachusetts Memorial Medical Center, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology 35. Use of Pseudo-observations in the Goodness-of-Fit Test for Gray's Time-Varying Coefficients Model Hyung-joo Kang1, MS; Chung-Chou Ho Chang2, PhD 1 University of Massachusetts Medical School, Preventive and Behavioral Medicine; 2University of Pittsburgh, Departments of Medicine and Biostatistics, School of Medicine and Graduate School of Public Health 36. A True Stories Campaign Uniformly Increased Awareness of State-Assisted Smoking Cessation Programs in Massachusetts Lois Keithly1, PhD, Rashelle Hayes2, PhD, Mark Paskowsky1, MS, Thomas Land1, PhD, Kevin Kane2, MS, Wenjun Li2, PhD 1 Massachusetts (MA) Tobacco Cessation and Prevention Program, MA Department of Public Health, Boston, MA; 2Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA

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37. Gender-Specific Factors Associated with Readiness to Quit Smoking among Korean Americans Sun S. Kim, David Kalman, Douglas Ziedonis Addiction Division, Department of Psychiatry, University of Massachusetts Medical School 38. A Content Analysis of Information and Support Needs in Women with Breast Cancer Who Use the Internet Sheryl LaCoursiere, PhD, FNP-BC, APRN1; Elizabeth Gallagher, RN, MS1 University of Massachusetts Boston1 39. Knowledge of and perceived need for evidence-based educational materials about antipsychotic medication safety by nursing home staff Celeste A. Lemay, RN, MPH; Sarah Foy, BA; Kathleen M. Mazor, EdD; Leslie R. Harrold, MD, MPH; Jennifer Donovan, Pharm D; Abir Kanaan, Pharm D, Becky A. Briesacher, PhD, Jerry H. Gurwitz, MD; Jennifer Tjia, MD, MSCE Meyers Primary Care Institute, University of Massachusetts Medical School, Reliant Medical Group, and the Fallon Community Health Plan 40. Induction of Colon Cancer Cell Death by Cranberry Proanthocyanidins via MAPK Pathway Anne M. Liberty1, Tracie P. Ferreira2 and Catherine C. Neto1 UMass Cranberry Health Research Center and 1Department of Chemistry and Biochemistry; 2 Department of Bioengineering, University of Massachusetts-Dartmouth, North Dartmouth, MA 41. Utilization and Outcomes of Patients with Colorectal Cancer Liver Metastases in the Medicare Population Christopher W. Macomber, SingChau Ng, YouFu Li, Karim Alavi, Heena Santry, Jennifer F. Tseng, Shimul A. Shah Department of Surgery Outcomes Analysis & Research, University of Massachusetts, Worcester, MA 42. Primary Care Physicians’ Views on Medical Error and Disclosure in Cancer Care Kathleen Mazor, EdD1; Cassandra Firneno, BA1; Celeste Lemay, RN1, Douglas Roblin, PhD2; Sarah Greene, MPH3; Carolyn Prouty DVM4; Beth Lapham, BA3; Brandi Robinson, MPH4; MPH; Ben Dunlap4, BA; Jane Anau, BA3; Thomas Gallagher, MD4 1 Meyers Primary Care Institute, University of Massachusetts Medical School, Reliant Medical Group, Fallon Community Health Plan, Worcester, MA; 2 The Center for Health Research-Southeast, Kaiser Permanente, Atlanta, GA; 3 Group Health Research Institute, Seattle, Washington; 4 University of Washington, Department of Medicine, Seattle, WA 43. Circulating microRNAs are associated with Paroxysmal or Persistent Atrial Fibrillation David D. McManus, MD1; Jeanine A. Ward, MD PhD2; Amir Y Shaikh, MD1; Khushleen Jaggi, MD1; Victor Ambros, PhD3; Jane E. Freedman, MD1; John F Keaney Jr., MD1 1 Departments of Medicine, 2Emergency Medicine, and 3Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655 44. Mid-gestation Angiogenic Biomarker Levels are Increased in Women at High Risk for Preeclampsia Tiffany A. Moore Simas, MD, MPH, MEd1ab; Sybil Crawford, PhD1c; Susie Bathgate, MD2a; Jing Yang, BS1d; Laura Robidoux, BS1a; Melissa Moore, PhD1d; Sharon Maynard, MD3e

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University of Massachusetts Medical School, Worcester, Massachusetts; 2George Washington University School of Medicine & Health Sciences, Washington, DD; 3Lehigh Valley Health Network, Allentown, PA; aOb/Gyn, bPediatrics, cMedcine, dNephrology, eBiochemistry & Molecular Pharmacology 45. Use of whole plant Artemisia annua L. as an antimalarial therapy Elfawal Mostafa1, Melissa J. Towler2, Ricardo Gazzinelli3, Douglas Golenbock3, Pamela J. Weathers2, Stephen M. Rich1 1 Dept. Plant, Soil and Insect Sciences, University of Massachusetts, Amherst, MA 01002; 2Dept. Biology and Biotechnology, Worcester Polytechnic Institute, Worcester MA 01609; 3Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 46. Incidence rates of ICU complications in moderate-severe traumatic brain injury (TBI) Susanne Muehlschlegel, MD, MPH1,2,3; Raphael Carandang, MD1,3; Cynthia Ouillette, RN1; Wiley Hall, MD1,3; Fred Anderson, PhD 3,4; Robert Goldberg, PhD5 Departments of 1Neurology (Div. Neurocritical Care), 2Anesthesia/Critical Care and 3Surgery; 4Center for Outcomes Research; 5Department of Quantitative Health Sciences (Div. Epidemiology of Chronic Diseases), University of Massachusetts Medical School, Worcester, MA 47. Impact of medical and neurological ICU complications on moderate-severe traumatic brain injury (TBI) Susanne Muehlschlegel, MD, MPH1,2,3; Raphael Carandang, MD1,3; Cynthia Ouillette, RN1; Wiley Hall, MD1,3; Fred Anderson, PhD 3,4; Robert Goldberg, PhD5 Departments of 1Neurology (Div. Neurocritical Care), 2Anesthesia/Critical Care and 3Surgery; 4Center for Outcomes Research; 5Department of Quantitative Health Sciences (Div. Epidemiology of Chronic Diseases), University of Massachusetts Medical School, Worcester, MA 48. Racial and Socioeconomic Disparities in Biological and Perceived Chronic Stress: Does Group Identification Matter? Kymberlee M. O’Brien, Ed Tronick and Celia L. Moore UMass, Boston, Dept of Psychology, Horizon Center 49. Healthy Food Accessibility in Grocery Stores in Central Massachusetts Barbara Olendzki, MPH, RD; Viji Patil, MS; Lili Chen, MS; Hua Zheng, PhD; Guoshu Yuan, MS; Elizabeth Procter-Gray, PhD; Wenjun Li, PhD Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 50. Use of the BRFSS Follow-up Surveys to Assess Awareness of the Massachusetts Medicaid Cessation Benefit Mark Paskowsky1, MS, Lois Keithly1, PhD, Lili Chen2, MS, Wenjun Li2, PhD 1 Massachusetts (MA) Tobacco Cessation and Prevention Program, MA Department of Public Health, Boston, MA; 2Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 51. Understanding Health Utilities in Women with Urinary Incontinence Danielle Patterson MD MSc¹, Michael Flynn, MD MHS1, Courtney Stachowski BS2 Abraham Morse MD MBA3 1 UMass Memorial Medical Center; 2Brigham Research Institute; 3Brigham and Women’s Hospital/Harvard Medical School

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52. Caspase-1-dependent, IL-1ß-mediated alcoholic steatohepatitis is ameliorated by IL-1 receptor antagonist treatment in mice Jan Petrasek, Shashi Bala, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, Evelyn A. Kurt-Jones, Gyongyi Szabo Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA 53. Is pancreatic cancer palliatable? A national study Elizaveta Ragulin Coyne1 MD MHS, Jillian Smith K1 MD MPH, Elan R. Witkowski1 MD, Sing-Chau Ng1 MS, Theodore McDade1 MD, Shimul A. Shah1 MD, Jennifer F Tseng2 MD. 1 University of Massachusetts Medical School, Department of Surgery, Surgical Outcomes Analysis & Research (SOAR), Worcester, MA; 2Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 54. Serum sodium values and their association with adverse outcomes in moderate-severe traumatic brain injury (TBI) Lucia Rivera-Lara1; Susanne Muehlschlegel, MD, MPH1,2,3; Raphael Carandang, MD1,3; Cynthia Ouillette, RN1; Wiley Hall, MD1,3; Fred Anderson, PhD 3,4; Robert Goldberg, PhD5 Departments of 1Neurology (Div. Neurocritical Care), 2Anesthesia/Critical Care and 3Surgery; 4Center for Outcomes Research; 5Department of Quantitative Health Sciences (Div. Epidemiology of Chronic Diseases), University of Massachusetts Medical School, Worcester, MA 55. Acute Care Surgery Patterns in the Current Era: Results of a Qualitative Study Heena P. Santry, MD MS1; Patricia L. Pringle, BA2; Timothy A. Emhoff1, MD; George C. Velmahos, MD PhD MSEd3; L.D. Britt, MD4; J. Lee Hargraves, PhD5; Catarina I. Kiefe, PhD MD6 1 Department of Surgery, University of Massachusetts Medical School and UMassMemorial Hospital; 2 University of Massachusetts Medical School; 3Department of Surgery, Massachusetts General Hospital; 4 Department of Surgery, Eastern Virginia Medical School; 5Department of Family Practice, University of Massachusetts Medical School; 6Department of Quantitative Health Sciences, University of Massachusetts Medical School 56. Not Just Full of Hot Air: Hyperbaric Oxygen Therapy Increases Survival in Cases of Necrotizing Soft Tissue Infections Joshua J. Shaw, Charles M Psoinos, Timothy A. Emhoff, Heena P. Santry Department of Surgery, Surgical Outcomes Analysis & Research (SOAR), University of Massachusetts Medical School, Worcester, MA 57. Do antipsychotic dose reduction trials result in worsening behavior among nursing home residents with dementia: a systematic review of the literature Jennifer Tjia, MD, MSCE; Abir Kanaan, Pharm D; Jennifer Donovan, Pharm D Meyers Primary Care Institute, University of Massachusetts Medical School, Reliant Medical Group, and the Fallon Community Health Plan 58. Cost Utility of Treatment of Stress Urinary Incontinence Emily Von Bargen DO; Danielle Patterson MD, MSc University of Massachusetts Memorial Medical Center, Department of Obstetrics and Gynecology, Division of Urogynecology and Reconstructive Pelvic Surgery

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59. Medication Errors in the Home: A Multisite Study of Children with Cancer Kathleen E. Walsh, M.D.,M.Sc.,1,2 Douglas W. Roblin, Ph.D.,3 Saul N. Weingart, M.D.,Ph.D.,4 Kathleen E. Houlahan, M.S.N., M.H.A., R.N.,4,5 Barbara Degar, M.D., 4,5 Amy Billett, M.D., 4,5 Christopher Keuker, M.D.,1 Colleen Biggins,2 Justin Li, 4 Karen Wasilewski, M.D.,6 Kathleen M. Mazor, Ed.D.,M.S.2,7 1 Department of Pediatrics, University of Massachusetts School of Medicine, Worcester, MA; 2Meyers Primary Care Institute, Worcester, MA; 3Kaiser Permanente Georgia, Atlanta, GA; 4Dana-Farber Cancer Institute, Boston, MA; 5Children’s Hospital Boston, Boston, MA; 6Emory Medical School, Atlanta, GA; 7 Department of Medicine, University of Massachusetts School of Medicine, Worcester, MA 60. Development of Lateral Flow Fluorescence Assay for the Detection of Trypanosoma Yuhong Wang1, Sam Nugen2 1 Department of Food Science, University of Massachusetts, Amherst, MA; 2Department of Food Science, University of Massachusetts, Amherst, MA 61. Biodegradable Wound Dressing for Skin Regeneration Scott E. Wharram1, Stephen McCarthy2; Raymond Dunn3; Ronald Ignotz3 1 CMB Sciences, Inc.; 2Department of Palstics Engineering, UMASS-Lowell; 3Division of Plastic Surgery, UMASS Medical School, Worcester, MA 62. Endemic Gallbladder Cancer: Is There a Role for Prophylactic Cholecystectomy? Elan R. Witkowski MD, Elizaveta Ragulin-Coyne MD MHS, Theodore P. McDade MD, Lily W. Chen BS, Heena P. Santry MD MS, Shimul A. Shah MD, Jennifer F. Tseng MD MPH Department of Surgery, Surgical Outcomes Analysis & Research (SOAR), University of Massachusetts Medical School, Worcester MA 63. NrasG12D oncogenic protein inhibits apoptotic Bim factor in preleukemic progenitors and synergizes with CBFβ-SMMHC in acute myeloid leukemia Liting Xue, Lucio H Castilla Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester MA 64. CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of HCV-infected cells and induction of IFNα Shuye Zhang, Karen Kodys, Gyongyi Szabo University of Massachusetts Medical School, Worcester, MA

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