Phenotyic and transcriptomic analysis of Plasmodium falciparum protein kinase A catalytic subunit inhibition Parasitology Research Nathalie Wurtz, Jérôme Desplans, and Daniel Parzy UMR-MD3 Relation hôte-parasites – Pharmacologie et Thérapeutique IRBA, Institut de Médecine Tropicale du Service de Santé des Armées – Antenne Marseille Allée du Médecin colonel Eugène Jamot, Parc du Pharo, BP 60109, 13262 Marseille Cedex 07, France. Corresponding authors:
[email protected] Tel: 04.91.15.01.14 Fax: 04.91.15.01.64
Supplemental Table S2 Accession numbera PF10_0322 PFL0285w PFA0705c PFA0025c PFB1005w PF14_0767 PFA0650w PFA0765c MAL13P1.405 PFL1920c PFF1105c PF14_0218 PFL2460w PFD1145c PFD0295c MAL13P1.176 PFD1155w PFD0110w
Description S-adenosylmethionine decarboxylase-ornithine decarboxylase glyoxalase II family protein, putative stevor pseudogene putative erythrocyte membrane protein 1 (PfEMP1) pseudogene rifin stevor, putative surface-associated interspersed gene pseudogene, (SURFIN) pseudogene erythrocyte membrane protein 1 (PfEMP1) erythrocyte membrane protein pfemp3, putative hydroxyethylthiazole kinase, putative chorismate synthase actin-related protein homolog, arp4 homolog coronin reticulocyte binding protein homolog 5, Rh5 apical sushi protein, ASP Plasmodium falciparum reticulocyte binding protein 2, homolog b erythrocyte binding antigen-165 normocyte-binding protein 1, pseudogene
Metabolic pathways Amino Acids Carbohydrates Cell-Cell Interactions Cell-Cell Interactions Cell-Cell Interactions Cell-Cell Interactions Cell-Cell Interactions Cell-Cell Interactions Cell-Cell Interactions Cofactors & Other Substances Cofactors & Other Substances Invasion and motility Invasion and motility Invasion and motility Invasion and motility Invasion and motility Invasion and motility Invasion and motility
Fold Standard change deviation -1,3 0,01 1,3 0,06 1,4 0,08 1,4 0,10 1,3 0,05 1,3 0,01 1,2 0,04 -1,2 0,04 -1,4 0,05 1,4 0,04 1,2 0,03 1,2 0,04 -1,2 0,03 -1,3 0,05 -1,3 0,05 -1,4 0,01 -1,4 0,04 -1,6 0,05
PFF0675c PF13_0198 PFD1150c PFL2520w MAL13P1.210 PFD1035w PFL2270w MAL13P1.285 PF14_0020 PFE0485w PF14_0280 PFI1245c PF08_0125 PF11_0061 PFE0450w PF10_0232 PFF1035w PFL2465c PFL0475w PFL0400w PF13_0059 PF14_0328 PFF1330c MAL13P1.327 PF10_0086 PFC0205c PFF1265w PFL0415w PF11_0128 PFL2000w PF13_0121 MAL13P1.335
myosin-like protein, putative reticulocyte binding protein 2 homolog a reticulocyte binding protein homolog 4, Rh4 Plasmodium falciparum, reticulocyte binding-like protein, homolog 3 dolichyl-phosphate-mannose-glygolipidalpha-mannosyltransferase steroid dehydrogenase kik-i, putative mannosyl transferase, putative Patatin-like phospholipase, putative choline kinase, putative phosphatidylinositol 4-kinase, putative phosphotyrosyl phosphatase activator, putative Protein phosphatase-beta tubulin gamma chain histone H4, putative chromosome condensation protein, putative Chromodomain-helicase-DNA-binding protein 1 homolog, putative Pfs77 protein thymidylate kinase, putative 3,5-cyclic-nucleotide phosphodiesterase, putative 50S ribosomal protein L29, putative ribosomal protein S15, mitochondrial precursor, putative mitochondrial import inner membrane translocase subunit tim17, putative mitochondrial import inner membrane translocase subunit, putative Ribosomal protein S17 homologue, putative adenylate kinase, putative PfGLP-1, 1-cys-glutaredoxin-like protein-1 oxidoreductase, short-chain dehydrogenase family, putative acyl carrier protein, mitochondrial precursor, putative coq4 homolog, putative mitochondrial carrier protein, putative dihydrolipoamide succinyltransferase, putative phosphatidylserine synthase i; putative
Invasion and motility Invasion and motility Invasion and motility Invasion and motility Lipids Lipids Lipids Lipids Lipids Lipids Mitosis and Chromosome Separation Mitosis and Chromosome Separation Mitosis and Chromosome Separation Mitosis and Chromosome Separation Mitosis and Chromosome Separation Mitosis and Chromosome Separation Mitosis and Chromosome Separation Nucleotides Nucleotides Organellar functions Organellar functions Organellar functions Organellar functions Organellar functions Organellar functions Organellar functions Organellar functions Organellar functions Organellar functions Organellar functions Organellar functions Organellar functions
-1,6 -1,6 -1,6 -1,7 1,4 1,2 1,2 -1,3 -1,3 -1,4 1,3 1,2 1,2 1,2 -1,4 -1,5 -1,5 1,3 -1,3 1,7 1,5 1,4 1,4 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
0,02 0,06 0,04 0,04 0,10 0,01 0,04 0,04 0,03 0,03 0,07 0,05 0,04 0,04 0,04 0,04 0,04 0,06 0,03 0,11 0,13 0,10 0,07 0,03 0,04 0,03 0,03 0,03 0,04 0,02 0,04 0,03
PF11_0062 PFE1470w PF14_0276 PF14_0334 PFD0215c MAL13P1.68 PF07_0112 PFC0595c MAL8P1.78 PFL0695c PF13_0021 PFL0120c PF11_0266 PFI1260c MAL13P1.44 PF13_0232 PFE0370c PF14_0110 PF14_0063 PF13_0211 MAL8P1.157 PF10_0177 PFL1885c PF07_0072 PFB0150c PFD0185c PF11_0381 PFB0665w PFD0895c PFF0060w PFA0065w MAL13P1.244
histone H2B cell cycle regulator protein, putative ribosomal protein L15, putative NAD(P)H-dependent glutamate synthase, putative pf52 protein peptidyl-prolyl cis-trans isomerase, putative proteasome subunit alpha type 5, putative serine/threonine protein phosphatase, putative small heat shock protein, putative geranylgeranyl transferase type2 beta subunit, putative small heat shock protein, putative cyclophilin, putative small nuclear ribonucleoprotein D1, putative Histone deacetylase protein phosphatase 2c-like protein, putative Casein kinase II regulatory subunit, putative subtilisin-like protease precursor, putative rhomboid protease, putative ATP-dependent Clp protease, putative calcium-dependent protein kinase ubiquitin-like protease 1 homolog, Ulp1 homolog, putative erythrocyte membrane-associated antigen calcium/calmodulin-dependent protein kinase 2, putative calcium-dependent protein kinase 4 protein kinase, putative peptidase subtilisin-like protease 2 Ser/Thr protein kinase, putative Bet3 transport protein, putative Plasmodium falciparum Maurers Cleft 2 transmembrane domain protein 6 Plasmdoium falciparum Maurers Cleft 2 transmembrane domain protein 1.1 TBC domain protein, putative
Organellar functions Organellar functions Organellar functions Organellar functions Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Post-translational modification Protein traffic Protein traffic Protein traffic Protein traffic
1,2 1,2 1,2 -1,2 1,6 1,6 1,3 1,3 1,3 1,2 1,2 1,2 1,2 1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,3 -1,3 -1,4 -1,4 -1,4 1,3 1,3 1,3 1,2
0,05 0,02 0,04 0,03 0,18 0,15 0,05 0,06 0,05 0,06 0,04 0,04 0,02 0,03 0,03 0,02 0,02 0,01 0,03 0,02 0,02 0,03 0,03 0,03 0,04 0,03 0,02 0,03 0,06 0,03 0,06 0,04
PFF0340c PF07_0036 PF14_0148 MAL13P1.64 PF14_0366 MAL7P1.145 PFE0205w PFF0285c PF13_0308 PF14_0437 PF14_0112 PFI1470c PFL2440w PFD0790c PFD0475c PFL0150w PFE1085w PF14_0194 PFB0245c PF14_0057 PF10_0175 MAL8P1.131 PF10_0269 MAL13P1.120 PFF0745c MAL13P1.14 PF11_0477 PFI0215c MAL8P1.110 PF14_0579 PF13_0316 PFD0355c
glutaredoxin-like protein, putative Cg6 protein uracil-DNA glycosylase, putative ubiquitin-like protein nedd8 homologue, putative small subunit DNA primase mismatch repair protein pms1 homologue, putative ATP-dependent helicase, putative DNA repair protein RAD50, putative DNA helicase helicase, truncated, putative POM1, putative leucine-rich repeat protein 8, LRR8 DNA repair protein rhp16, putative DNA replication licensing factor, putative replication factor a protein, putative origin recognition complex 1 protein DEAD-box subfamily ATP-dependent helicase, putative spliceosome-associated protein, putative DNA-directed RNA polymerase II 16 kDa subunit, putative RNA binding protein, putative tRNA pseudouridine synthase, putative Gas41 homologue, putative DNA-directed RNA polymerase II, putative splicing factor, putative ribonuclease, putative ATP-dependent DEAD box helicase, putative CCAAT-box DNA binding protein subunit B signal peptidase, putative plastid 50S ribosomal protein L33, putative ribosomal protein L27, putative 40S ribosomal protein S13 Peptidyl-tRNA hydrolase PTH2, putative
Redox Metabolism Redox Metabolism Replication Replication Replication Replication Replication Replication Replication Replication Replication Replication Replication Replication Replication Replication Transcription Transcription Transcription Transcription Transcription Transcription Transcription Transcription Transcription Transcription Transcription Translation Translation Translation Translation Translation
1,3 1,2 1,3 1,2 1,2 1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,3 -1,3 -1,4 1,3 1,2 1,2 1,2 1,2 1,2 1,2 -1,2 -1,2 -1,3 -1,4 1,4 1,3 1,3 1,3 1,2
0,08 0,03 0,07 0,04 0,03 0,02 0,01 0,02 0,02 0,02 0,03 0,02 0,02 0,01 0,03 0,05 0,04 0,07 0,04 0,05 0,02 0,02 0,02 0,03 0,03 0,04 0,06 0,06 0,08 0,07 0,07 0,05
PFD0960c PF11_0438 MAL8P1.51 PF13_0350 PF13_0222 PFB0210c PF11_0059 MAL13P1.301 PFC0135c PF13_0019 PF13_0271 PF11_0199 PFI1395w PFF0640w PFE0105c PF14_0037 PF14_0424 PF11_0186 MAL13P1.415 PFE1135w PF11_0038 PFC0241w PFL0750w PFD1075w PF14_0705 PFL1195w PFD0915w PFE1615c PF11_0363 PF14_0034 PF08_0057 PFB0620w
ribosomal protein L7Ae-related protein, putative Ribosomal protein, putative protein-transport protein sec61 beta 1 subunit, putative signal recognition particle receptor alpha subunit, putative RNA lariat debranching enzyme, putative hexose transporter, PfHT1 metabolite/drug transporter protein with aminophospholipid-transporting P-ATPase and guanyl cyclase domains nuclear export receptor, crm1 homolog sodium/hydrogen exchanger, Na+, H+ antiporter ABC transporter, (heavy metal transporter family) hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein, pseudogene hypothetical protein, conserved hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical membrane protein, conserved hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein
Translation Translation Translation Translation Transport Transport Transport Transport Transport Transport Transport Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown
1,2 1,2 1,2 -1,4 1,3 1,3 1,2 -1,3 -1,3 -1,3 -1,3 1,8 1,6 1,5 1,5 1,5 1,5 1,4 1,4 1,4 1,4 1,4 1,4 1,4 1,4 1,4 1,4 1,4 1,3 1,3 1,3 1,3
0,05 0,04 0,04 0,05 0,09 0,06 0,06 0,02 0,04 0,02 0,05 0,23 0,07 0,14 0,12 0,05 0,12 0,06 0,08 0,04 0,07 0,09 0,10 0,06 0,09 0,09 0,09 0,05 0,03 0,08 0,06 0,06
PFI1330c MAL8P1.138 PFI0280c PF14_0755 PF13_0031 MAL7P1.173 PF10_0276 PFF1320c PF14_0662 PF07_0109 PFI1660w PFE1100w PF10_0007 PFI0965w PFL0515w PF11_0068 PFD1065c MAL7P1.99 PFF1090c MAL13P1.50 PF14_0317 PFL0205w PFL0765w PFL2445c PFF0240c PFE0510c PFB0395w PF11_0088 PF14_0200 MAL7P1.33 PFE1440c PFF0580w
hypothetical protein, conserved hypothetical protein, conserved autophagocytosis associated protein, putative hypothetical protein tRNA intron exonumclease, putative hypothetical protein hypothetical protein troponin c-like protein, putative hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein conserved protein, putative hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical membrane protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown
1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3 1,3
0,06 0,06 0,07 0,06 0,09 0,07 0,07 0,04 0,05 0,06 0,06 0,07 0,02 0,03 0,08 0,05 0,07 0,05 0,03 0,04 0,07 0,05 0,06 0,05 0,05 0,07 0,04 0,04 0,06 0,06 0,03 0,06
MAL13P1.129 PFL0175c PF11_0453 PFB0575c MAL13P1.345 MAL8P1.122 PFC0126c PF13_0260 MAL13P1.251 PF13_0347 PFE1450c PFI0920c PFL2435w PFB0880w PFE0560c MAL13P1.223 PF10_0130 PFB0910w PFB0932w PFC0555c PFB0391c PF13_0054 PF11_0431 MAL8P1.114 PFE1175w MAL13P1.229 PFF0545c PF13_0053 PFI0150c PF11_0487 PF10_0370 PF13_0134
hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved Dihydrouridine synthase, putative hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein transcription factor, putative membrane skeletal protein, putative hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein Enhancer of rudimentary homolog, putative hypothetical protein, conserved
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
0,06 0,04 0,05 0,04 0,04 0,05 0,06 0,05 0,05 0,05 0,03 0,05 0,05 0,04 0,05 0,03 0,03 0,04 0,03 0,04 0,04 0,03 0,05 0,02 0,02 0,02 0,03 0,05 0,03 0,04 0,05 0,03
MAL13P1.159 PF10_0066 PFF0105w PFL2370c PFL0435w PFL1755w PFB0660w PF11_0346 PFI0970c PF10_0112 MAL13P1.262 PFI1335w PFE1235c PF14_0530 PFI1580c PFL1010c PFA0210c PF14_0692 PF14_0363 PF10_0247 PFE1485w MAL8P1.163 PF11_0371 PF10_0286 PF08_0124 PF08_0082 MAL7P1.146 PF08_0089 PF11_0316 MAL8P1.150 PFA0405w PFI1200w
hypothetical protein, conserved hypothetical protein MYND finger domain protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein TLD domain, putative hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein ferlin, putative DHHC-type zinc finger protein, putative hypothetical protein conserved hypothetical protein, conserved hypothetical protein metacaspase-like protein hypothetical protein hypothetical protein, conserved hypothetical protein, conserved in P.falciparum hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2
0,03 0,03 0,02 0,04 0,04 0,03 0,03 0,03 0,02 0,03 0,02 0,03 0,03 0,02 0,02 0,02 0,02 0,03 0,03 0,03 0,02 0,03 0,03 0,03 0,03 0,02 0,03 0,02 0,02 0,02 0,01 0,03
PFE0440w PF13_0104 PFD0445c PFC0540w PF10_0168 PFE0495w PFL0470w PF10_0163 PF11_0116 PF14_0386 PFB0279w PFD0380c PF10_0140 PF11_0342 PF14_0470 PF11_0168 PF14_0333 PFA0180w PF10_0083 PF11_0193 MAL7P1.132 MAL13P1.269 PF14_0440 MAL8P1.70 PF10_0281 PF11_0210 PF13_0047 PF14_0552 PF11_0185 PF14_0196 MAL13P1.260 PF11_0241
hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown
-1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,2 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3
0,03 0,02 0,03 0,03 0,03 0,04 0,03 0,00 0,04 0,02 0,02 0,00 0,04 0,04 0,04 0,03 0,02 0,04 0,04 0,03 0,03 0,03 0,04 0,04 0,02 0,03 0,04 0,04 0,02 0,05 0,02 0,04
PF14_0583 PF08_0074 PFL1045w PFB0680w PFL1650w PFF0965c PFD0390c PFB0190c PFE1285w PF14_0135 PF11_0480 PF11_0277 PF11_0268 MAL13P1.29 PFE0385w PF14_0383 PFF0990c MAL13P1.102 PF13_0210 PF11_0213 PFD0320c PFD0885c PFB0765w PF14_0120 MAL13P1.145 MAL13P1.112 PFE0070w PFC0965w PFL2335w PF10_0156 PFI1210w PFL2110c
hypothetical protein DNA/RNA-binding protein Alba, putative hypothetical protein, conserved hypothetical protein hypothetical protein, conserved hypothetical membrane protein, conserved AAA family ATPase, putative hypothetical protein hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein hypothetical protein, conserved hypothetical protein,conserved interspersed repeat antigen, putative hypothetical protein, conserved hypothetical protein, conserved hypothetical protein hypothetical protein, conserved hypothetical protein, conserved
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown
-1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,3 -1,4 -1,4 -1,4 -1,4 -1,4 -1,4
0,04 0,04 0,04 0,03 0,04 0,04 0,03 0,02 0,03 0,05 0,02 0,02 0,04 0,04 0,04 0,03 0,03 0,04 0,03 0,04 0,05 0,05 0,04 0,03 0,05 0,04 0,05 0,03 0,02 0,05 0,05 0,03
PF10_0072 hypothetical protein PF10_0211 hypothetical protein PF11_0442 hypothetical protein MAL13P1.202 hypothetical protein, conserved PFC1045c hypothetical protein, conserved PF08_0035 hypothetical protein, conserved PFL1320w hypothetical protein, conserved PFE0700c hypothetical protein, conserved PF11_0490 hypothetical protein PFF0505c hypothetical protein, conserved PFL1705w hypothetical protein, conserved PF10_0357 hypothetical protein PF14_0226 hypothetical protein PF10_0079 hypothetical protein PF08_0008 hypothetical protein, conserved PFL1165w hypothetical protein, conserved PF14_0703 hypothetical protein PFL2100w hypothetical protein, conserved PF10_0262 hypothetical protein PF14_0172 hypothetical protein PF11_0278 hypothetical protein PFI0540w hypothetical protein, conserved PFE0360c hypothetical protein, conserved a accession number from Plasmodium Genome Resource database (www.plasmodb.org) The genes colored in red belong to the calcium/calmodulin and kinases signaling network The genes colored in green belong to the invasion/motility pathway (RBL genes) The genes colored in blue belong to nuclear genes with mitochondrial signal sequence
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown
-1,4 -1,4 -1,4 -1,4 -1,4 -1,4 -1,4 -1,4 -1,4 -1,4 -1,5 -1,5 -1,5 -1,5 -1,5 -1,5 -1,6 -1,6 -1,6 -1,7 -1,7 -1,8 -2,0
0,04 0,05 0,04 0,03 0,03 0,05 0,05 0,05 0,02 0,03 0,04 0,03 0,06 0,05 0,05 0,03 0,04 0,05 0,03 0,03 0,07 0,02 0,04
