3 Gedeon Richter Plc. Chemical Works of Gedeon Richter Plc. is a leading Central-Eastern European pharmaceutical company with its headquarters in Hungary. The multinational company is vertically integrated, Richter is engaged not only in the manufacture but the research and development, and marketing of pharmaceutical products, too. The parent company owns manufacturing subsidiaries in five countries; its products are available, through its own distribution network, to the inhabitants of nearly 100 different countries. Richter blends the century-old traditions of Hungarian pharmaceutical production with the high technological standards of modern times. Our main objectives are to deliver advanced medicines to the public, as well as, through our operations, assist in the region’s development, help the growth of Hungarian economy and boost the country’s competitiveness. Corporate social responsibility is a top priority: environment protection, economic and social sustainability are major concerns in the Company’s strategy. On a mission to improve the quality of human life, Gedeon Richter seeks to serve a healthier future generation in the new millennium.

4

5 Past, present, future

Richter Group sales 2003-2010 (€ million) 1000

The secret of the Company’s success lies, amongst others,

The young pharmacist always recognized and took

in its pool of experience and invaluable expertise,

advantage of new opportunities, laid great emphasis on

accumulated over more than a century. It was in 1901 that

international relations, the development of pharma­ceu­

the Company’s founder, pharmacist Gedeon Richter

t­i­cal preparations and quality in general. It was not mere luck but top-level expertise and ceaseless inno­va­tion that brought and continues to bring about success. Albeit suffering heavy losses, the Company managed to pull through the turbulent 20th century thanks to the unique expertise, excellent workforce and management. Today, Richter has not only succeeded in retaining its

892

942

952

2008

2009

998

794

800 696

600



400

575

592

200

0

2003

2004

2005

2006

2007

2010

influential position in the domestic market but has evolved into one of Central-Eastern Europe’s largest multinational pharmaceutical corporations with a growing

The issue of exchangeable bonds in 2004 and then in 2009

the Richter Group’s dynamic growth, the Company will

presence in CIS nations, the European Union and the

enabled Richter to continue its strategy as the Hungarian

continue to execute significant investments and conclude

United States of America.

state remains a shareholder and continues to exercise its

additional strategic agreements both in the field of R&D

ownership rights in the medium term.

and marketing.

In 1990, as the first step of a privatization process,

Besides maintaining excellent performance in the United

the state-owned enterprise became a joint-stock

States and the European Union, our intention remains

Based on its net sales figures and operating profit, Richter

obtained a license to produce medicines. He bought

company for the second time. Its registered shares

to further enhance the Company’s multinational role in

received the “Top 200 – Best Hungarian company of

“Sas” pharmacy, still today owned and operated by

were introduced to the Budapest Stock Exchange on 9

the region and to continue delivering therapeutically

the year 2007” award from an independent professional

the Company, and started small-scale pharmaceutical

November 1994 and soon were listed among the four

advanced yet affordable products.

jury set up by Hungarian financial weekly “Figyelő”.

production. Later, he decided on production on

Hungarian blue chips.

an industrial scale and, in 1907, set up a modern

Privatization offerings in 1994, 1995 and 1997 led to

Another strategic objective is the constant renewal of

regional expansion and the establishment of cross-border

pharmaceutical factory on the outskirts of Budapest.

a reduction in the state’s shareholding in the Company.

our product portfolio. To realize this goal and ensure

business relations.

The Company was also rewarded for its achievements in

7

6 Hungarian company

Ownership structure

Founded in 1901, Richter remains the only Hungarian

economic interests into account in its decisions.

There are no international strategic investors amongst

company, now of a multinational size, which retains

We concentrate our investments and R&D activity

Richter shareholders that is, Richter – unique with regard

its independence as it operates under Hungarian

in Hungary and offer employment for nearly 5000

to the Hungarian pharma sector – is not owned by an

management without an international strategic investor.

Hungarians. Production takes place at two sites in

international pharmaceutical company, and thus

Consequently, the management takes national

Hungary: Budapest and Dorog.

corporate strategy continues to be defined by the Hungarian management. In order to maintain its strategy and ensure Richter’s dynamic growth, it is essential that the Company retains its independence in decision-making and strengthens both its leading role in the region and its international

Contribution to Hungarian economy (HUF bn) 2008

strategic partnerships. This serves both shareholder

2004

2005

2006

2007

2009

2010

Investments

24.2

25.7

26.3

17.8

16.6

21.1

16.4

R&D

10.4

12.1

13.8

17.1

18.0

23.4

25.5

Taxes

14.1

15.7

17.2

21.0

22.2

24.6

23.7

Total

48.7

53.5

57.3

55.9

56.8

69.1

65.6

inte­rests and those of the Hungarian economy as a whole.

Ownership structure (2010) MNV Zrt. (Hungarian State Holding Company) 25% International investors 63%

Domestic investors 12%

9

8 In Poland

Richter Group In its primary activities of rese­arch and development,

tradi­ti­onal markets, together with the establishment

manufac­tu­ring and marketing of pharmaceutical products,

and deve­lop­ment of our specialized marketing

Gedeon Richter is supported by a number of subsidiaries,

network have laid the foundation for a strong regional

joint ventures and associated companies. The Richter

multinational Group. The Company has strengthened

Group comprises these companies and the Hungarian

its regional multinational role through acquisitions and

parent company. Thanks to well-es­tab­lished synergies, the

a combination in Romania, Poland and Germany while

Richter Group’s performance means more than a simple

through the establishment of greenfield investments in

association of the individual performances of its members.

Russia and India, Richter has also expanded its network of

Our manu­­facturing sub­sid­iaries, which operate in Richter’s

manufacturing bases.

A new member joined the Richter Group on 12 November

The finished product manufacturing unit was modernized

2002 when Gedeon Richter, as a strategic investor, acquired

and significant infrastructure, IT and environment protection

a 51% majority stake in the new Polish pharmaceutical

projects were completed. Besides the finished dosage product

manufacturer to be founded with Polfa. Richter’s ownership

plant, a pilot plant and a warehouse were also constructed,

in the company has since increased to 99.8% and a five-year

making Gedeon Richter Polska one of the most modern

capital expenditure program has been recently concluded.

pharmaceutical facilities in Poland.

11

10 In Russia Gedeon Richter has been a household name in Russia for 50 years. Owing to its reliable, effective and affordable products, the Company has always been very popular on the Russian market. In 1996 the decision was made to set up a manufacturing unit near Moscow. Three years later the manual manufacturing facility began operations and in the autumn of 2001 the subsidiary “Gedeon Richter RUS” was officially inaugurated. The Richter Group’s Russian member manufactures and packages products covering several therapeutic areas. Among these are antiallergic, cardiovascular, antiulcer, antiinflammatory, tranquillizer and antibacterial preparations.

In Romania The history of Tirgu Mures-based Gedeon Richter Romania dates

developments in the past few years, including the setting up of

back to 1985, when the foundation stone of the pharmaceutical

a regional development laboratory and a logistics centre, the

plant Armedica was laid. Manufacturing began four years later.

development of tabletting, ointment and finished dosage plants

It was in 1998 that Richter purchased a 50.98% majority stake in

and the modernization of service units, the modern preparations

the company from the Romanian state. In 2003 the company’s

produced by the Romanian subsidiary comply with required

name changed to Gedeon Richter Romania S. A. and as a result of

regulations and the company has successfully undergone several

additional injections of capital Richter’s ownership in GR Romania

Romanian and Hungarian GMP inspections.

has reached almost 100%. One of the tenets of the medium

Richter operates an extensive distribution network in Romania,

and long-term strategy was the setting up of a marketing

and is the majority owner of a pharmaceutical retail and a

network, a quality assurance system and the establishment of

pharmaceutical wholesale company. In addition, a 120 unit

all conditions necessary for pharmaceutical manufacturing to

pharmacy chain assists in the promotion and sale of products

conform to international standards. Thanks to continuous facility

manufactured by the Richter Group.

13

12 In Germany

In India

Following a Euros 22.9 million acquisition, the Richter-

Business relations between Gedeon Richter Plc. and the Indian

Helm biotechnological joint venture company was

company Themis date back to 1969 when they became joint

established in the German town of Dengelsberg in 2007.

venture partners for the production of APIs and formulations.

The new company, owned 70% by Richter and 30% by

In 2004 Themis Medicare, in which Richter has 5% equity, and

Helm employs 200 staff and comprises a state-of-the-art

Richter decided to expand their cooperation and established

plant for the bacterial type of biotechnology together

a new company under the name Richter-Themis Medicare

with an R&D laboratory and pilot plant.

Private Ltd., with a shareholding ratio of 51% Richter and 49%

Sales analysis by region (2010) Other countries 6%

USA

11% EU

CIS

34%

37% Hungary

12%

Themis Medicare.

Unique market network Unique among Central-Eastern European firms, the market

German Grünenthal’s oral contraceptive portfolio offers a

network of Gedeon Richter covers five continents with its

platform for Richter to establish its sales and marketing teams

products reaching nearly one hundred countries around the

in key Western European countries. More than 80 per cent of

world. The Company is present in more than thirty countries

the Company’s revenue is generated by exports (876 million

thanks to its five production sites, thirty one representative

euros in 2010). Of key importance in Richter’s strategy is the

offices, twenty one commercial subsidiaries and wholesale

maintenance and enhancement of a strong market position

joint ventures. Richter’s market network branches into many

in the traditional markets of the CIS countries, especially Russia,

countries in the European Union; moreover, it extends into

and the Central-Eastern Europe­an region, where Richter plays

the United States, Japan, the CIS countries and the Eastern

the role of a regio­nal multinational company. However, we also

region. The Company operates an exten­sive marketing and

place great emphasis on strengthening our market presence

distribution network in Hungary, the CIS and Eastern Europe.

in the US and EU since these remain major contributors to our

Furthermore, the acquisition of Swiss PregLem and that of

excellent performance.

15

14 10 Richter Group

(for contact information, please visit http://www.richter.hu)

Subsidiaries and joint ventures in production Germany, Bovenau – Richter-Helm BioLogics GmbH & Co KG

Subsidiaries and joint ventures in production Commercial subsidiaries Representative offices

India, Vapi – Richter Themis Medicare (India) Private Ltd. Poland, Grodzisk – Gedeon Richter Polska Sp. z o.o.

Romania, Târgu Mureş – Gedeon Richter Romania S.A. Russia, Yegoryevsk – ZAO Gedeon Richter RUS CJSC

Representative offices Armenia, Yerevan Azerbaijan, Baku Belarus, Minsk Bulgaria, Sofia China, Shanghai Czech Republic, Prague Estonia, Tallinn Georgia, Tbilisi India, Mumbai

Kazakhstan, Almaty Kyrgyzstan, Bishkek Latvia, Riga Lithuania, Vilnius Moldova, Chisinau Mongolia, Ulan Bator Russia, Irkutsk Russia, Kazan Russia, Khabarovsk Russia, Krasnodar Russia, Moscow Russia, Novosibirsk Russia, Saint Petersburg Russia, Volgograd Russia, Yekaterinburg Serbia, Belgrade Slovakia, Bratislava Tajikistan, Dushanbe Turkmenistan, Ashgabat Ukraine, Kiev Uzbekistan, Tashkent Vietnam, Ho Chi Minh City Commercial subsidiaries Armenia, Yerevan – SP OOO RichterLambron, SP OOO Gedeon Richter Apteka Austria, Vienna – Gedeon Richter Austria GmbH Azerbaijan, Baku – SP OOO Vita-Richter France, Paris – Gedeon Richter France S.A.R.L.

Germany, Eschborn – Gedeon Richter Pharma GmbH Germany, Hamburg – Richter-Helm Biotec GmbH & Co. KG Italy, Milan – Gedeon Richter Italia s.r.l. Jamaica, Kingston – Medimpex West Indies Ltd. Moldova, Chisinau – Richpangalfarma S.R.L., Gedeon Richter-Retea Farma­ceutica S.R.L. Poland, Warsaw – Gedeon Richter Marketing Polska Sp. z o.o. Portugal, Lisbon – Gedeon Richter Portugal, Lda Romania, Cluj-Napoca – SC Phar­ma­ pharm Romania S.A. Romania, Corunca – Gedeon Richter Farmacia S.A. Spain, Barcelona – Gedeon Richter Ibérica S.A. Switzerland, Cham – Gedeon Richter (Schweiz) AG Ukraine, Kiev – OOO Gedeon Richter Ukrfarm Ukraine, Vyshneve – PAT Gedeon Richter UA United Kingdom, London – Gedeon Richter UK Ltd. USA, Ridgewood – Gedeon Richter USA Inc.

17

16 Efficient, affordable products – worldwide

In the service of innovation Original pharmaceutical molecular research and continuous

The Richter brand is known and respected all over the world. The

innovation have been defining elements of Richter’s strategy

Company produces about one hundred pharmaceutical products

since its establishment in 1901. Today, with a 900-strong

in more than 170 presentations. Among its products are original,

research and development team in Hungary, the Company

generic and licensed preparations, offering effective, advanced and

has evolved into the Central-Eastern European region’s most

affordable treatments for many therapeutic areas. Whilst our

important center for pharmaceutical research.

R&D efforts are focused on drugs for the central nervous system, we also attach great importance to the development and produc­

Besides carrying out original research, the Company

tion of cardiovascular and gastrointestinal preparations and oral

is also engaged in the development of generic drugs

contraceptives. The product range is constantly expanding as new

and chemical processes. Our original pharmaceutical

products are introduced.

research activities focus exclusively on drugs of the central nervous system – especially treatments for chronic pain, schizophrenia and anxiety. Richter believes that innovation, technological standards and agility are the

Products by therapeutic area (2010)

three most important ingredients of original research.

Gynecology Central Nervous System

Therefore, the Company has devoted significant financial

33%

resources to the modernization of biological laboratories

14%

and that of the general R&D infrastructure in the past few Muscle relaxants

6%

years. A new experimental technological laboratory was completed during 2006, where high quality APIs, suitable for clinical trials, may be produced on kilogram scale. In 2007 construction work on a chemical-analytical

Other

Cardiovascular

18% Gastrointestinal

4%

25%

19

18

research centre that meets the highest quality and technological requirements, together with an adjoining office block, was also completed. When compared with other Hungarian firms Gedeon Richter spends the highest ratio, on average 10 per cent of its revenue (amounting to HUF 27.1 billion in 2010) on research and development – ranking it second in the Central-Eastern European region. As an acknowledgement of the Company’s innovative activity, the World Intellectual Property Organization awarded Gedeon Richter the WIPO Gold Medal for Inventors in 1996. For its achievements in active ingredient research, the Company also won the Innovation Award of the Hungarian Innovation Society in 1995, 1996, 1997, 2001, 2005, and 2010 and the Innovation Grand Award in 2003 and 2006. Moreover, our hypertensive preparation was rewarded with the

The future pharmaceutical industry in Richter today

”Drug of the Year – 2006” award. For any company thinking to the longer term, it is vital to

Consequently, in 2007 Gedeon Richter Plc. made the

have a presence in new fields that can provide breakout

strategic decision to enter this field through the

points in the future. For the pharmaceutical sector

establishment of biotechnological R&D and

biotechnology provides such an opportunity.

manufacturing facilities.

21

20 Gynecology – an area of focus The following year the Company commenced the

Richter has been employing biotechnological processes for

For Richter gynecological therapy is an area of strategic

construction of a plant for the development and

more than four decades, mainly in the production of

importance in which the Company is a leading player

manufacture of biopharmaceutical products in the

steroid intermediates and APIs with sterile fermentation.

even by international standards. Its major goal is to be

Hungarian city of Debrecen, with total expenditure

The Company boasts a solid tradition and expertise in both

a trustworthy partner for women and physicians alike.

expected to be in the region of HUF 15 billion. The new

development and manufacture. Thanks to its R&D efforts

Gedeon Richter is one of the few companies in the world

manufacturing unit is seen as not only a milestone in the

and positive results, Richter remains one of the most

which offer a comprehensive gynecology portfolio from

realization of Richter’s strategic goals but also a significant

significant centers of research in Central-Eastern Europe.

the most advanced oral and emergency contraceptives

step forward in enhancing the competitiveness of

Richter has executed major investments in the field of

to antifungal and hormone replacement therapy products.

Hungarian industry and thereby also that of Hungary.

biotechnology in the past few years. In November 2005 the

Moreover, the Company is determined to expand its

Company announced the completion of a laboratory,

product range continuously. Our employees’ internationally

The new biotechnological unit in Debrecen offers a good

unique in Hungary at the time, suitable for large-scale

acknowledged expertise in steroid chemistry and active

example of the strategic goals of Richter, a company both

fermentation of recombinant proteins for human use.

pharmaceutical ingredient development, the cost-effective

based in Hungary and operated by a Hungarian

large-scale production, together with facilities that comply

management team. The Company intends to establish a

Following a Euros 22.9 million acquisition, the Richter-Helm

with the strictest quality standards ensure a competitive

The acquisitions well complement Richter’s existing

complex and competitive biopharma line which will help

biotechnological joint venture company was established in

advantage that provides solid ground for further growth.

women’s health franchise as the portfolio will cover

expand its domestic and international product portfolio

the German town of Dengelsberg in 2007. The new

with products offering high added value. Moreover, the

company, owned 70% by Richter and 30% by Helm, employs

The acquisition of Swiss pharmaceutical company PregLem

to the elderly (i.e. oral and emergency contraception,

project will assist in the introduction of biotechnology, as

200 staff and as the youngest member of the Richter Group

was a major milestone in 2010, since PregLem now

gynecological infections, treatment for benign

a sector representing high intellectual added value, to

comprises a state-of-the-art plant, for the bacterial type of

constitutes Richter’s original research and development

gynecological conditions such as endometriosis, uterine

Hungary and thus increase the country’s competitiveness

biotechnology and the production of recombinant proteins,

centre focusing on gynecology, more precisely on

fibroids, post surgical abdominal adhesions, infertility as

while also creating 110 new jobs.

together with an R&D laboratory and pilot plant.

gynecological conditions with significant unmet medical

well as osteoporosis and hormone replacement therapy).

needs. On the other hand, the purchase of German

The US market is of special importance with regard to the

Grünenthal’s oral contraceptive portfolio offers a unique

export of Richter gynecological products as the Company

opportunity for Richter both to strengthen its presence

delivers both steroid APIs and finished dosage products

in Western European markets and to further expand the

in large quantities to the US.

the medical needs of all age groups from adolescents

company’s existing female healthcare business.

23

22 Quality

Co-operation

It is essential that pharmaceutical products are

The Company considers it essential to establish research

universities and also those of the Hungarian Academy of

produced with uniformly consistent quality. That is

partnerships to facilitate the development and marketing

Science. The Company runs joint research projects with

why, in addition to expertise, modern equipment and

of new molecules. By forming alliances with foreign

more than thirty such institutions. Richter’s efforts are well

manufacturing technologies play an important role

pharmaceutical manufacturers and research institutions,

illustrated by the research laboratory, specializing in the

in the pharmaceutical industry. At Richter we have

Richter intends to transfer international experience to serve

source and alleviation of pain, which was set up by the

dedicated ourselves to the continual improvement of

Hungarian innovation.

Transdanubian Regional Research Center at the University

quality assurance. The Company rigorously observes both

Richter supports talented youths not only in their positions

of Pécs with the assistance of a generous contribution

domestic and international regulations and guidelines

at the Company but at the research facilities of Hungarian

from Richter.

and compliance is regularly monitored by Hungarian, European and US quality control authorities in all fields of production. Richter quality meets the highest requirements. All this is clear proof that Hungarian pharmaceuticals have quality equal to any on the world market. Owing to the strict quality requirements and increasing demands of our partners, Richter is dedicated to continuous investment.

25

24 Sustainable development

Ethics

Sustainable development is a crucial aspect of Richter’s

Richter has received various awards in the last few years

Since its establishment, Gedeon Richter has demon­

strategy. It is by taking into consideration economic, envi­r­on­

for its activity as a good corporate citizen – in 2001

stra­ted a strong ethical behavior in business and

mental and social concerns that the Company pre­pares its

Hunga­rian financial weekly „Figyelő” recognized the Com­

expects the same from its partners and employees. As

long-term plans and, thus, safeguards the futu­re of share­

pany’s sense of responsibility while the Patron Dip­lo­ma

recognition of the Company’s outstanding business

holders, employees and its immediate envi­ron­ment. In line

in 2004 acknowledged Richter’s intensive patro­na­ge.

ethics, Gedeon Richter received the Business Ethics

with its corporate social responsibility policy, Richter maintains

Further­more, Richter received the Kármán Tódor Prize

Award in 2003.

a dialogue with its partners, share­­holders, repre­­sen­tatives of

twice, in 2000 and 2005, for its special support of Hunga­

civil society and the relevant government authorities.

rian education, adult training and scientific research as

Safety in the workplace as well as compliance with health

well as Braun & Partners’ Good CSR award in 2009 for

and environment protection standards are key ingredients

responsible corporate governance.

of Richter’s CSR policy. Environmental performance is carried out under the umbrella of an Environmental Man­a­ge­­ment System implementing ISO 14001 standards and first certified in 2001. Similar, workplace safety and health is guaranteed by the ISO 28001-compliant Occu­pa­tional Health and Safety Management System, certified in 2006. Richter’s commitment towards its immediate environment and society at large takes many forms. On the one hand, Richter products offer treatment for patients while our research activity contributes to the discovery of little-known therapeutic areas. On the other hand, we recognize that it is our responsibility to assist community objectives according to our capabilities. Richter believes it should dedi­ca­te its efforts to the areas strongly connected to its business activity and in line with this belief the Company is an avid supporter of Hungarian health care and education.

26 Planning for the long term Traditions and respect for the past are important for our Company. In 2001, we decided to set up a museum that provides information on the one-hundred-year history of the Company. This unique exhibition on the history of the pharmaceutical industry attracts domestic and international business partners, pharmaceutical experts, physicians, students and enthusiasts of industrial and local history alike. The history of Hungarian pharmaceutical manufacturing, along with Richter, goes back more than one hundred years. Rightly known and acknowledged worldwide, the Hungarian ”gray matter” put itself on record with several brilliant technical solutions, chemical processes and other innovations. It is the long generations of chemists, engineers, doctors, pharmacists and technological experts that provide a solid foundation for Richter’s long-term success. Our intention remains to further enhance the Company’s multinational role and to continue delivering therapeutically advanced yet affordable products. Another strategic objective is the constant renewal of our product portfolio. To realize our goals and ensure the Richter Group’s dynamic growth, the Company will continue to execute significant investments and conclude additional strategic agreements both in the field of R&D and marketing with an independent ownership structure.

Gyömrői út 19–21., Budapest H-1103, Hungary Telephone: +36 1 431 4000, +36 20 885 2000 Fax: +36 1 260 6650, +36 1 260 4891 [email protected] • www.richter.hu

2011