Paper. Tong Chuang Feng, # Wang Yui Ying, Ren Jang Hua, Yale Y Ji, Marc de Gasparo

Paper Keywords: restenosis, endothelin, angiotensinreceptor blockade, valsartan, bradykinins Effect of valsartan and captopril in rabbit carotid inj...
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Keywords: restenosis, endothelin, angiotensinreceptor blockade, valsartan, bradykinins

Effect of valsartan and captopril in rabbit carotid injury. Possible involvement of bradykinin in the antiproliferative action of the renin-angiotensin blockade Tong Chuang Feng,#† Wang Yui Ying,† Ren Jang Hua, Yale Y Ji,† Marc de Gasparo §



95 postgraduate, Hubei Medical University, 39 Donghu Road, Wuhan 430071 China #

Second affiliated Hospital of Huben Medical University, Wuhan, 430071 China §

Novartis Pharma AG, Metabolic, Cardiovascular and Endocrine Therapeutic Area, 4002 Basel Switzerland Correspondence to: Dr Yale Y Ji Beijing Novartis Pharma Ltd, 14/F, China World Tower 2, No 1 Jian Guo Men Wai Avenue Beijing 100004 P.R. China. Tel: +86 10650 58833 Fax: +86 10650 57310 E-mail: yale_yayou.j@ pharma.novartis.com Accepted for publication 17th January 2001 JRAAS 2001;2:19–24

Journal of the ReninAngiotensinAldosterone System (Including other peptidergic systems)

March 2001 Volume 2 Number 1

Abstract The effects of the specific angiotensin II (Ang II) AT1receptor blocker valsartan on events related to restenosis were investigated in rabbits after common carotid balloon injury. Six animals were given valsartan from two days prior to injury until 14 days post-injury. Three control groups (n=6 in each group) were either sham-operated, untreated or treated with the angiotensin-converting enzyme (ACE) inhibitor, captopril. Both ACE inhibition and AT1-receptor blockade had marked effects on plasma levels of endothelin ET1, thromboxane TXB2 and 6-keto-PGF1alpha. The most dramatic effects on ET1 levels were seen in rabbits treated with valsartan, where levels were reduced to values close to those for sham-operated animals (96.85 vs. 86.45 pg/ml). Captopril treatment led to a statistically significant (p

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