Our company in Africa

Karl-Ludwig Kley,

Chairman of the Executive Board

Stefan Oschmann, Chairman-Elect of the Executive Board

Press Conference Johannesburg, November 20, 2015

HEALTHCARE, LIFE SCIENCE & PERFORMANCE MATERIALS 1668

founded

66

countries*

~50,000 employees*

€1.7 bn

invested in R&D in 2014*

~€15 bn

sales in 2015**

* including Sigma Aldrich ** pro-forma combined sales of our company and Sigma Aldrich

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Full-year 2015 guidance including Sigma-Aldrich Our guidance for 2015, updated Nov 12, 2015 (including Sigma Aldrich for 43 days)

Net sales:

~ €12.6 – 12.8 bn

thereof Sigma:

~ €300 m

EBITDA pre: ~ €3,580 – 3,650 m thereof Sigma:

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~ €80 - 95 m

EPS pre:

~ €4.80 – 4.95

thereof Sigma:

~ €0.10 – 0.15

What we do

Healthcare Prescription medicines to treat, for example, cancer, multiple sclerosis and infertility, over-the-counter pharmaceuticals for everyday health protection or to provide fast relief of colds and pain, as well as innovations in the areas of allergies and biosimilars.

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Life Science Innovative tools and laboratory supplies for the life science industry that make research and biotech production easier, faster and more successful.

Performance Materials A wide range of specialty chemicals, such as liquid crystals for displays, effect pigments for coatings and cosmetics, or high-tech materials for the electronics industry.

Healthcare

Global market leader in fertility medicine Gold standard drugs for diabetes and hypertension

World’s largest supplier of drugs to treat thyroid disorders Global market leader in probiotic vitamins (Bion®) Global market leader in B vitamins (Neurobion®) European market leader in pregnancy vitamins (Femibion®)

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Healthcare Our key therapeutic areas

Oncology

Neurodegenerative diseases

Fertility

Endocrinology

Cardio-metabolic diseases

Erbitux®

Rebif®

Gonal-f®

Saizen®

Glucophage®

Colorectal cancer, head and neck cancer

Relapsing multiple sclerosis

Infertility

Growth hormone disorders

Type 2 diabetes

Luveris®/Ovidrel® Female infertility

Serostim®

Concor®

HIV-associated wasting

Cardio-vascular diseases Euthyrox® Thyroid disorders

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Healthcare Our strong brands

Neurobion®

Bion®

Nasivin®

Kytta®

Femibion®

B vitamins to treat slight neuropathic pain

Probiotic vitamins for daily immune protection

Nasal spray – clears the nose in 25 seconds

Help for muscle, joint and back pain

Vitamins for women who wish to conceive, during pregnancy and while nursing

Seven Seas®

Vigantoletten®

Sangobion®

Floratil®

Apaisyl®

Protecting strong joints and basic health

Vitamin D3 products to help with tiredness, fatigue and listlessness

For the prevention of iron deficiency in adults, children and babies

Probiotic treatment of diarrhea

Specialized skincare products for mosquito bites and head lice

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Life Science

Global market leader in bioprocessing tools

One of the leading suppliers of laboratory chemicals, lab water instruments and consumables

Leading supplier

of chromatography products

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Title of Presentation| DD.MM.YYYY

Performance Materials

Global market

and technology leader in liquid crystals for displays

Global market leader in effect pigments

99% of high-end smartphones contain

microprocessor chips that have been made smaller and faster thanks to our materials

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In 1668, Friedrich Jacob Merck purchased the Angel Pharmacy (Engel-Apotheke) in Darmstadt, which would become the historic core of the company. This makes us the world’s oldest pharmaceutical and chemical company. The Angel Pharmacy exists to this day and is a state-of-the-art pharmacy that is still owned by the family.

1668 – A NEW HORIZON 10

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Title of Presentation| DD.MM.YYYY

We unite the best of two worlds

Merck KGaA

Darmstadt, Germany Family Equity interest 70.3% Family-owned for 12 generations

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Total capital 100%

Shareholders Share capital 29.7% Publicly traded since 1995 DAX member since 2007

Our presence in Africa

Algeria

Tunisia Egypt

Ghana

Nigeria

Ethiopia Kenya

Angola

South Africa 12

Mozambique

Our company in Africa Our commitment to Africa

We for a Healthy Africa WHY?

HOW?

Supporting healthy families, healthy communities, healthy economies

Advancing healthy living

Eliminating Schistosomiasis IP Sharing R&D WHAT?

Innovating for quality of life

Sharing knowledge, building skills

Fighting counterfeits (MiniLabs)

CAP

One company for Children

Rural pharmacy

Hospital water purification programme

Biopharma products

Biopharma products,

Life Science - water for health

Life Science products

Heritage and Values

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Afrika kommt!

Excellence Academy WASH Programme Life Science products (process solution)

More than 200,000 people die from schistosomiasis every year. In children, the parasitic worm disease stunts also growth and reduces their ability to learn. Together with the WHO, we have taken up the fight against this condition. Thanks to our praziquantel tablets, 64 million patients have already received treatment. And we intend to continue the fight – until schistosomiasis has been eliminated in Africa.

WE’VE GOT SOMETHING AGAINST WORMS 14

Capacity advancement program 5 year program focusing on diabetes, hypertension, infertility and cancer.

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Aiming to expand professional capacity in the areas of R&D, supply-chain integrity and efficiency, pharmacovigilance, medical education, and community awareness.

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Already trained more than 7,000 medical students on 3 continents – and are aiming to reach 25,000 students by the end of 2018

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Diabetes awareness efforts reached out to 60,000 people in India, Kenya, Uganda and Ghana in 2014. We want to provide free diabetes screenings and education to 300,000 people by 2016.

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Working to build the research capacity of the African scientific research community as well as to showcase innovative research in Africa.

Muse HIV-virus-testing - easy to use and at low cost Muse highlights Monitoring patients’ CD4+ T lymphocyte cell counts and CD4% are standard indicators of when to begin treatment for opportunistic infections, initiate antiretroviral therapy, and monitor the progression of diseases such as HIV.  Low platform cost  Low cost per test  No special expertise required  Single test  Robust  Portable  Results in only a few steps  Testing in adults and children Also possible and worked on: Muse Malaria Kit – a new diagnostic for malaria and related infectious diseases 16

Our company in Africa Malaria is a major global health challenge: Worldwide recognition that Malaria control requires integrated strategies

 Vector is female Anopheles spp.

Treatment

 Pathogens are protozoans from Plasmodium spp.

 2.65 billion people at risk of malaria  198 million infections  584,000 deaths from malaria

Detection

Control strategies Program required Transmission

 90% of deaths in Africa  78% of deaths are children