Original Article Causes and management of hyperbilirubinemia in full-term newborns

Int J Clin Exp Med 2016;9(6):12060-12066 www.ijcem.com /ISSN:1940-5901/IJCEM0022782 Original Article Causes and management of hyperbilirubinemia in f...
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Int J Clin Exp Med 2016;9(6):12060-12066 www.ijcem.com /ISSN:1940-5901/IJCEM0022782

Original Article Causes and management of hyperbilirubinemia in full-term newborns Yan-Ping Zhu1, Jun Wang2, Ming-Xia Li1 Department of Neonatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, P. R. China; 2Department of Pediatrician, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, P. R. China 1

Received December 27, 2015; Accepted May 4, 2016; Epub June 15, 2016; Published June 30, 2016 Abstract: Objective: To investigate the major causes and current management of hyperbilirubinemia in full-term newborns in a general hospital. Methods: The clinical and laboratory data of 1,455 full-term newborns with hyperbilirubinemia in the department of neonatology were collected for retrospective and descriptive analysis. Univariate logistic analysis was used to compare the risk factors for hyperbilirubinemia in these two groups (the mild-to-moderate and severe jaundice groups). The impact of feeding models (breastfeeding, formula feeding, and mixed feeding) on bilirubin metabolism in inpatients was analyzed. The severity of hyperbilirubinemia was compared in inborn and outborn groups. Results: The top three major causes of hyperbilirubinemia in hospitalized full-term newborns were jaundice of unknown cause, jaundice due to early feeding insufficiency, and breastfeeding jaundice. Comparison between the mild-to-moderate and severe jaundice groups showed that hemolytic disease of the newborn and neonatal infection were two main risk factors in the severe jaundice group (P