Odyssey®
Publications List – Cancer Selected from 358 publications from July 1, 2014 – February 29, 2016, in HighWire
Spring 2016
Volume 6
Table of Contents Breast Cancer..................................................... 2
Other Cancers..................................................... 8
Brain Cancer / Glioma......................................... 2
Angiogenesis...................................................... 9
Colon / Colorectal Cancer................................... 3
Apoptosis......................................................... 10
Leukemia / Lymphoma....................................... 3
Autophagy........................................................ 10
Liver Cancer....................................................... 4
Cell Signaling / Signal Transduction................. 11
Lung Cancer....................................................... 5
Invasion / Metastasis........................................ 12
Melanoma / Skin Cancer.................................... 5
MMP................................................................. 13
Ovarian Cancer................................................... 6
microRNA / miRNA / siRNA / RNAi.................. 13
Pancreatic Cancer............................................... 7
PTEN................................................................. 14
Prostate Cancer.................................................. 7
Telomerase / Telomere...................................... 15
Thyroid Cancer................................................... 8
Therapy / Trials................................................. 15
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Dr. Michael Lee Assistant Professor University of Massachusetts Medical School
2 Odyssey® Publications List – Cancer
Volume 6
Breast Cancer Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers Arvind Arora, Tarek M.A. Abdel-Fatah, Devika Agarwal, Rachel Doherty, Deborah L. Croteau, Paul M. Moseley, Khalid Hameed, Andrew Green, Mohammed A. Aleskandarany, Emad A. Rakha, Karl Patterson, Graham Ball, Stephen Y.T. Chan, Ian O. Ellis, Vilhelm A. Bohr, Helen E. Bryant, and Srinivasan Madhusudan
Carcinogenesis, Jan 2016; 37: 63 - 71.
PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer Jaekwang Jeong, Joshua N. VanHouten, Pamela Dann, Wonnam Kim, Catherine Sullivan, Herbert Yu, Lance Liotta, Virginia Espina, David F. Stern, Peter A. Friedman, and John J. Wysolmerski
PNAS, Jan 2016; 113: E282 - E290.
Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases
Kazuharu Kai, Kimie Kondo, Xiaoping Wang, Xuemei Xie, Mary K. Pitner, Monica E. Reyes, Angie M. Torres-Adorno, Hiroko Masuda, Gabriel N. Hortobagyi, Chandra Bartholomeusz, Hideyuki Saya, Debu Tripathy, Subrata Sen, and Naoto T. Ueno
Mol. Cancer Ther., Dec 2015; 14: 2687 - 2699.
Therapeutic targeting of casein kinase 1d in breast cancer
Laura H. Rosenberg, Marie Lafitte, Victor Quereda, Wayne Grant, Weimin Chen, Mathieu Bibian, Yoshihiko Noguchi, Mohammad Fallahi, Chunying Yang, Jenny C. Chang, William R. Roush, John L. Cleveland, and Derek R. Duckett
Science Translational Medicine, Dec 2015; 7: 318ra202.
Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer Cells via Src-Focal Adhesion Kinase and Forkhead Box Protein M1 Eduardo Sanabria-Figueroa, Siobhan M. Donnelly, Kevin C. Foy, Meghan C. Buss, Robert C. Castellino, Elisavet Paplomata, Latonia Taliaferro-Smith, Pravin T.P. Kaumaya, and Rita Nahta
Mol. Pharmacol., Dec 2014; 87: 150 - 161.
High-Throughput Time-Resolved FRET Reveals Akt/PKB Activation as a Poor Prognostic Marker in Breast Cancer Selvaraju Veeriah, Pierre Leboucher, Julien de Naurois, Nirmal Jethwa, Emma Nye, Tamara Bunting, Richard Stone, Gordon Stamp, Véronique Calleja, Stefanie S. Jeffrey, Peter J. Parker, and Banafshé Larijani
Cancer Res., Sep 2014; 74: 4983 - 4995.
5’-AMP-activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors Keith R. Laderoute, Joy M. Calaoagan, Wan-ru Chao, Dominc Dinh, Nicholas Denko, Sarah Duellman, Jessica Kalra, Xiaohe Liu, Ioanna Papandreou, Lidia Sambucetti, and Laszlo G. Boros
J. Biol. Chem., Aug 2014; 289: 22850 - 22864.
Breast Cancer / Glioma Mir-21–Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact
Pratheesh Sathyan, Pascal O. Zinn, Anantha L. Marisetty, Bin Liu, Mohamed Mostafa Kamal, Sanjay K. Singh, Pierre Bady, Li Lu, Khalida M. Wani, Bethany L. Veo, Joy Gumin, Dina Hamada Kassem, Frederick Robinson, Connie Weng, Veerabhadran Baladandayuthapani, Dima Suki, Howard Colman, Krishna P. Bhat, Erik P. Sulman, Ken Aldape, Rivka R. Colen, Roel G.W. Verhaak, Zhimin Lu, Gregory N. Fuller, Suyun Huang, Frederick F. Lang, Raymond Sawaya, Monika Hegi, and Sadhan Majumder
J. Neurosci., Nov 2015; 35: 15097 - 15112.
Glycogen Synthase Kinase 3β Sustains Invasion of Glioblastoma via the Focal Adhesion Kinase, Rac1, and c-Jun N-Terminal Kinase-Mediated Pathway Yuri Chikano, Takahiro Domoto, Takuya Furuta, Hemragul Sabit, Ayako Kitano-Tamura, Ilya V. Pyko, Takahisa Takino, Yoshimichi Sai, Yutaka Hayashi, Hiroshi Sato, Ken-ichi Miyamoto, Mitsutoshi Nakada, and Toshinari Minamoto
Mol. Cancer Ther., Feb 2015; 14: 564 - 574.
3 Odyssey® Publications List – Cancer
Volume 6
Mis-Trafficking of Endosomal Urokinase Proteins Triggers Drug-Induced Glioma Nonapoptotic Cell Death Nagarekha Pasupuleti, Ana Cristina Grodzki, and Fredric Gorin
Mol. Pharmacol., Feb 2015; 87: 683 - 696.
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells
Stefano Bartesaghi, Vincenzo Graziano, Sara Galavotti, Nick V. Henriquez, Joanne Betts, Jayeta Saxena, Valentina Minieri, Deli A, Anna Karlsson, L. Miguel Martins, Melania Capasso, Pierluigi Nicotera, Sebastian Brandner, Vincenzo De Laurenzi, and Paolo Salomoni
PNAS, Jan 2015; 112: 1059 - 1064.
Kruppel-like Factor-9 (KLF9) Inhibits Glioblastoma Stemness through Global Transcription Repression and Integrin α6 Inhibition Mingyao Ying, Jessica Tilghman, Yingying Wei, Hugo Guerrero-Cazares, Alfredo Quinones-Hinojosa, Hongkai Ji, and John Laterra
J. Biol. Chem., Nov 2014; 289: 32742 - 32756.
Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells Christopher M. Furcht, Janine M. Buonato, Nicolas Skuli, Lijoy K. Mathew, Andrés R. Muñoz Rojas, M. Celeste Simon, and Matthew J. Lazzara
J. Cell Sci., Aug 2014; 127: 3555 - 3567.
Colon / Colorectal Cancer AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival Kurt W. Fisher, Binita Das, Hyun Seok Kim, Beth K. Clymer, Drew Gehring, Deandra R. Smith, Diane L. Costanzo-Garvey, Mario R. Fernandez, Michael G. Brattain, David L. Kelly, John MacMillan, Michael A. White, and Robert E. Lewis
Mol. Cell. Biol., Nov 2015; 35: 3866 - 3879.
ERBB4 is over-expressed in human colon cancer and enhances cellular transformation
Christopher S. Williams, Jessica K. Bernard, Michelle Demory Beckler, Dana Almohazey, Mary Kay Washington, Jesse J. Smith, and Mark R. Frey
Carcinogenesis, Jul 2015; 36: 710 - 718.
Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial–mesenchymal transition Hong Liu, Guoping Ren, Tingyang Wang, Yuexia Chen, Chaoju Gong, Yanfeng Bai, Bo Wang, Hongyan Qi, Jing Shen, Lijun Zhu, Cheng Qian, Maode Lai, and Jimin Shao
Carcinogenesis, Apr 2015; 36: 459 - 468.
Complement 5a Enhances Hepatic Metastases of Colon Cancer via Monocyte Chemoattractant Protein-1-mediated Inflammatory Cell Infiltration Chunmei Piao, Lun Cai, Shulan Qiu, Lixin Jia, Wenchao Song, and Jie Du
J. Biol. Chem., Apr 2015; 290: 10667 - 10676.
IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Fei Huang, Han Chang, Ann Greer, Stephen Hillerman, Karen A. Reeves, Warren Hurlburt, John Cogswell, Dharmesh Patel, Zhenhao Qi, Craig Fairchild, Rolf-Peter Ryseck, Tai W. Wong, Friedrich G. Finckenstein, Jeffrey Jackson, and Joan M. Carboni
Mol. Cancer Ther., Feb 2015; 14: 620 - 630.
Leukemia / Lymphoma Inactivation of the p53–KLF4–CEBPA Axis in Acute Myeloid Leukemia
Katja Seipel, Miguel Teixera Marques, Marie-Ange Bozzini, Christina Meinken, Beatrice U. Mueller, and Thomas Pabst
Clin. Cancer Res., Feb 2016; 22: 746 - 756.
Cellular Mechanisms Underlying Complete Hematological Response of Chronic Myeloid Leukemia to BRAF and MEK1/2 Inhibition in a Patient with Concomitant Metastatic Melanoma Miles C. Andrews, Natalie Turner, Janis Boyd, Andrew W. Roberts, Andrew P. Grigg, Andreas Behren, and Jonathan Cebon
Clin. Cancer Res., Dec 2015; 21: 5222 - 5234.
4 Odyssey® Publications List – Cancer
Volume 6
Leukemia inhibitory factor attenuates renal fibrosis through Stat3-miR-29c Ying Yu, Yumei Wang, Yangyang Niu, Lanjun Fu, Y. Eugene Chin, and Chen Yu
Am J Physiol Renal Physiol, Oct 2015; 309: F595 - F603.
PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome
Ashley Pandolfi, Robert F. Stanley, Yiting Yu, Boris Bartholdy, Gopichand Pendurti, Kira Gritsman, Jacqueline Boultwood, Jonathan Chernoff, Amit Verma, and Ulrich Steidl
Blood, Aug 2015; 126: 1118 - 1127.
Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia Rongqing Pan, Vivian R. Ruvolo, Jun Wei, Marina Konopleva, John C. Reed, Maurizio Pellecchia, Michael Andreeff, and Peter P. Ruvolo
Blood, Jul 2015; 126: 363 - 372.
Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML Sewa Rijal, Shaun Fleming, Nik Cummings, Natalie K. Rynkiewicz, Lisa M. Ooms, Nhu-Y. N. Nguyen, Tse-Chieh Teh, Sharon Avery, Julie F. McManus, Anthony T. Papenfuss, Catriona McLean, Mark A. Guthridge, Christina A. Mitchell, and Andrew H. Wei
Blood, Apr 2015; 125: 2815 - 2824.
The PML domain of PML–RARα blocks senescence to promote leukemia
Katharina Korf, Harald Wodrich, Alexander Haschke, Corinne Ocampo, Lena Harder, Friederike Gieseke, Annika Pollmann, Kevin Dierck, Sebastian Prall, Hannah Staege, Hui Ma, Martin A. Horstmann, Ronald M. Evans, and Thomas Sternsdorf
PNAS, Aug 2014; 111: 12133 - 12138.
Calpain 5 Is Highly Expressed in the Central Nervous System (CNS), Carries Dual Nuclear Localization Signals, and Is Associated with Nuclear Promyelocytic Leukemia Protein Bodies
Ranjana Singh, M. Kathryn Brewer, Charles B. Mashburn, Dingyuan Lou, Vimala Bondada, Brantley Graham, and James W. Geddes
J. Biol. Chem., Jul 2014; 289: 19383 - 19394.
Liver Cancer Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells Bal Krishan Sharma, Ravindra Kolhe, Stephen M. Black, Jonathan R. Keller, Nahid F. Mivechi, and Ande Satyanarayana
FASEB J, Jan 2016; 30: 262 - 275.
Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus Hung Huynh, Huai-Xiang Hao, Stephen L. Chan, David Chen, Richard Ong, Khee Chee Soo, Panisa Pochanard, David Yang, David Ruddy, Manway Liu, Adnan Derti, Marissa N. Balak, Michael R. Palmer, Yan Wang, Benjamin H. Lee, Dalila Sellami, Andrew X. Zhu, Robert Schlegel, and Alan Huang
Mol. Cancer Ther., May 2015; 14: 1224 - 1235.
MiR-1188 at the imprinted Dlk1-Dio3 domain acts as a tumor suppressor in hepatoma cells Wei Cui, Zhijun Huang, Hongjuan He, Ning Gu, Geng Qin, Jie Lv, Tao Zheng, Kenkichi Sugimoto, and Qiong Wu
Mol. Biol. Cell, Apr 2015; 26: 1416 - 1427.
FOXA2 suppresses the metastasis of hepatocellular carcinoma partially through matrix metalloproteinase-9 inhibition
Jian Wang, Chang-Peng Zhu, Ping-Fang Hu, Hui Qian, Bei-Fang Ning, Qing Zhang, Fei Chen, Jiao Liu, Bin Shi, Xin Zhang, and Wei-Fen Xie
Carcinogenesis, Nov 2014; 35: 2576 - 2583.
Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice Hadley J. Hartwell, Keiko Y. Petrosky, James G. Fox, Nelson D. Horseman, and Arlin B. Rogers
PNAS, Aug 2014; 111: 11455 - 11460.
5 Odyssey® Publications List – Cancer
Volume 6
Lung Cancer IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis
Gavin D. Brooks, Louise McLeod, Sultan Alhayyani, Alistair Miller, Prudence A. Russell, Walter Ferlin, Stefan Rose-John, Saleela Ruwanpura, and Brendan J. Jenkins
Cancer Res., Feb 2016; 76: 866 - 876.
Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non–Small Cell Lung Cancer Alexandra B. Lantermann, Dongshu Chen, Kaitlin McCutcheon, Greg Hoffman, Elizabeth Frias, David Ruddy, Daniel Rakiec, Joshua Korn, Gregory McAllister, Frank Stegmeier, Matthew J. Meyer, and Sreenath V. Sharma
Cancer Res., Nov 2015; 75: 4937 - 4948.
Tumor-suppressive p53 Signaling Empowers Metastatic Inhibitor KLF17-dependent Transcription to Overcome Tumorigenesis in Non-small Cell Lung Cancer Amjad Ali, Muhammad Zeeshan Bhatti, Abdus Saboor Shah, Hong-Quan Duong, Huda Mohammad Alkreathy, Shah Faisal Mohammad, Rahmat Ali Khan, and Ayaz Ahmad
J. Biol. Chem., Aug 2015; 290: 21336 - 21351.
The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα– and Extracellular Signal-Regulated Kinase 1/2–Dependent Mechanism Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J. López, Silvia Terés, Rafael Alvarez, María Alonso-Sande, Xavier Busquets, and Pablo V. Escribá
J. Pharmacol. Exp. Ther., Jul 2015; 354: 213 - 224.
Optimizing the Sequence of Anti-EGFR–Targeted Therapy in EGFR-Mutant Lung Cancer
Catherine B. Meador, Hailing Jin, Elisa de Stanchina, Caroline A. Nebhan, Valentina Pirazzoli, Lu Wang, Pengcheng Lu, Huy Vuong, Katherine E. Hutchinson, Peilin Jia, Xi Chen, Rosana Eisenberg, Marc Ladanyi, Katerina Politi, Zhongming Zhao, Christine M. Lovly, Darren A.E. Cross, and William Pao
Mol. Cancer Ther., Feb 2015; 14: 542 - 552.
Genetic modifiers of EGFR dependence in non-small cell lung cancer
Tanaz Sharifnia, Victor Rusu, Federica Piccioni, Mukta Bagul, Marcin Imielinski, Andrew D. Cherniack, Chandra Sekhar Pedamallu, Bang Wong, Frederick H. Wilson, Levi A. Garraway, David Altshuler, Todd R. Golub, David E. Root, Aravind Subramanian, and Matthew Meyerson
PNAS, Dec 2014; 111: 18661 - 18666.
The Antiparasitic Drug, Potassium Antimony Tartrate, Inhibits Tumor Angiogenesis and Tumor Growth in Nonsmall-Cell Lung Cancer Beibei Wang, Weiwei Yu, Jiawei Guo, Xingwu Jiang, Weiqiang Lu, Mingyao Liu, and Xiufeng Pang
J. Pharmacol. Exp. Ther., Nov 2014; 352: 129 - 138.
Melanoma / Skin Cancer Cellular Mechanisms Underlying Complete Hematological Response of Chronic Myeloid Leukemia to BRAF and MEK1/2 Inhibition in a Patient with Concomitant Metastatic Melanoma Miles C. Andrews, Natalie Turner, Janis Boyd, Andrew W. Roberts, Andrew P. Grigg, Andreas Behren, and Jonathan Cebon
Clin. Cancer Res., Dec 2015; 21: 5222 - 5234.
Antioxidants can increase melanoma metastasis in mice
Kristell Le Gal, Mohamed X. Ibrahim, Clotilde Wiel, Volkan I. Sayin, Murali K. Akula, Christin Karlsson, Martin G. Dalin, Levent M. Akyürek, Per Lindahl, Jonas Nilsson, and Martin O. Bergo
Science Translational Medicine, Oct 2015; 7: 308re8.
Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
Amine Sadok, Afshan McCarthy, John Caldwell, Ian Collins, Michelle D. Garrett, Maggie Yeo, Steven Hooper, Erik Sahai, Sandra Kuemper, Faraz K. Mardakheh, and Christopher J. Marshall
Cancer Res., Jun 2015; 75: 2272 - 2284.
6 Odyssey® Publications List – Cancer
Volume 6
Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma Jordan Wengrod, Ding Wang, Sarah Weiss, Hua Zhong, Iman Osman, and Lawrence B. Gardner
Sci. Signal., Mar 2015; 8: ra27.
Antitumor Activity of the MEK Inhibitor TAK-733 against Melanoma Cell Lines and Patient-Derived Tumor Explants
Lindsey N. Micel, John J. Tentler, Aik-Choon Tan, Heather M. Selby, Kelsey L. Brunkow, Kelli M. Robertson, S. Lindsey Davis, Peter J. Klauck, Todd M. Pitts, Esha Gangolli, Robyn Fabrey, Shawn M. O'Connell, Patrick W. Vincent, and S. Gail Eckhardt
Mol. Cancer Ther., Feb 2015; 14: 317 - 325.
First Experience on Laparoscopic Near-Infrared Fluorescence Imaging of Hepatic Uveal Melanoma Metastases Using Indocyanine Green Quirijn R. J.G. Tummers, Floris P. R. Verbeek, Hendrica A. J.M. Prevoo, Andries E. Braat, Coen I. M. Baeten, John V. Frangioni, Cornelis J. H. van de Velde, and Alexander L. Vahrmeijer
Surgical Innovation, Feb 2015; 22: 20 - 25.
MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
Diego Ploper, Vincent F. Taelman, Lidia Robert, Brian S. Perez, Björn Titz, Hsiao-Wang Chen, Thomas G. Graeber, Erika von Euw, Antoni Ribas, and Edward M. De Robertis
PNAS, Feb 2015; 112: E420 - E429.
Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression
Linda K. Rushworth, Andrew M. Kidger, Laurent Delavaine, Graeme Stewart, Susanne van Schelven, Jane Davidson, Christopher J. Bryant, Edward Caddye, Philip East, Christopher J. Caunt, and Stephen M. Keyse
PNAS, Dec 2014; 111: 18267 - 18272.
Ovarian Cancer Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells Amit Kumar Srivastava, Chunhua Han, Ran Zhao, Tiantian Cui, Yuntao Dai, Charlene Mao, Weiqiang Zhao, Xiaoli Zhang, Jianhua Yu, and Qi-En Wang
PNAS, Apr 2015; 112: 4411 - 4416.
A Novel Neutralizing Antibody Targeting Pregnancy-Associated Plasma Protein-A Inhibits Ovarian Cancer Growth and Ascites Accumulation in Patient Mouse Tumorgrafts Marc A. Becker, Paul Haluska, Jr, Laurie K. Bale, Claus Oxvig, and Cheryl A. Conover
Mol. Cancer Ther., Apr 2015; 14: 973 - 981.
The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer Leo Y. Luo, Eejung Kim, Hiu Wing Cheung, Barbara A. Weir, Gavin P. Dunn, Rhine R. Shen, and William C. Hahn
Mol. Cancer Res., Mar 2015; 13: 502 - 509.
The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer
Fang Fang, Joanne Munck, Jessica Tang, Pietro Taverna, Yinu Wang, David F.B. Miller, Jay Pilrose, Gavin Choy, Mohammad Azab, Katherine S. Pawelczak, Pamela VanderVere-Carozza, Michael Wagner, John Lyons, Daniela Matei, John J. Turchi, and Kenneth P. Nephew
Clin. Cancer Res., Dec 2014; 20: 6504 - 6516.
Histone H1.3 Suppresses H19 Noncoding RNA Expression and Cell Growth of Ovarian Cancer Cells Magdalena Medrzycki, Yunzhe Zhang, Weijia Zhang, Kaixiang Cao, Chenyi Pan, Nathalie Lailler, John F. McDonald, Eric E. Bouhassira, and Yuhong Fan
Cancer Res., Nov 2014; 74: 6463 - 6473.
7 Odyssey® Publications List – Cancer
Volume 6
Pancreatic Cancer Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer Jacob L. Houghton, Brian M. Zeglis, Dalya Abdel-Atti, Robert Aggeler, Ritsuko Sawada, Brian J. Agnew, Wolfgang W. Scholz, and Jason S. Lewis
PNAS, Dec 2015; 112: 15850 - 15855.
Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo Charles W. Kimbrough, Anil Khanal, Matthew Zeiderman, Bigya R. Khanal, Neal C. Burton, Kelly M. McMasters, Selwyn M. Vickers, William E. Grizzle, and Lacey R. McNally
Clin. Cancer Res., Oct 2015; 21: 4576 - 4585.
PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer Hiroaki Ono, Marc D. Basson, and Hiromichi Ito
Mol. Cancer Res., Aug 2015; 13: 1174 - 1184.
Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer Sabiha Kazim, Mokenge P. Malafa, Domenico Coppola, Kazim Husain, Sherma Zibadi, Trinayan Kashyap, Marsha Crochiere, Yosef Landesman, Tami Rashal, Daniel M. Sullivan, and Amit Mahipal
Mol. Cancer Ther., Jul 2015; 14: 1570 - 1581.
Small-Animal PET Imaging of Pancreatic Cancer Xenografts Using a Antibody, MAb159
Cu-Labeled Monoclonal
64
Hui Wang, Dan Li, Shuanglong Liu, Ren Liu, Hong Yuan, Valery Krasnoperov, Hong Shan, Peter S. Conti, Parkash S. Gill, and Zibo Li
J. Nucl. Med., Jun 2015; 56: 908 - 913.
Targeted Noninvasive Imaging of EGFR-Expressing Orthotopic Pancreatic Cancer Using Multispectral Optoacoustic Tomography Shanice V. Hudson, Justin S. Huang, Wenyuan Yin, Sabrin Albeituni, Jamie Rush, Anil Khanal, Jun Yan, Brian P. Ceresa, Hermann B. Frieboes, and Lacey R. McNally
Cancer Res., Nov 2014; 74: 6271 - 6279.
Prostate Cancer P1-9-1 • Proteomics profiling of epigenetic proteins during acinar morphogenesis to identify prostate cancer prognostic markers Chih-Pin Chuu, Ching-Yu Lin, and Kelvin K. Tsai
Ann. Onc., Nov 2015; 26: vii122.
The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells Lingling Fan, Guihong Peng, Arif Hussain, Ladan Fazli, Emma Guns, Martin Gleave, and Jianfei Qi
J. Biol. Chem., Aug 2015; 290: 20865 - 20879.
Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies Siu Chiu Chan, Luke A. Selth, Yingming Li, Michael D. Nyquist, Lu Miao, James E. Bradner, Ganesh V. Raj, Wayne D. Tilley, and Scott M. Dehm
Nucleic Acids Res., Jul 2015; 43: 5880 - 5897.
KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90α in Prostate Cancer Cells
Weiya Liu, George A. Vielhauer, Jeffrey M. Holzbeierlein, Huiping Zhao, Suman Ghosh, Douglas Brown, Eugene Lee, and Brian S. J. Blagg
Mol. Pharmacol., Jun 2015; 88: 121 - 130.
Dual Targeting of the Androgen Receptor and Hypoxia-Inducible Factor 1α Pathways Synergistically Inhibits Castration-Resistant Prostate Cancer Cells Elena V. Fernandez, Kelie M. Reece, Ariel M. Ley, Sarah M. Troutman, Tristan M. Sissung, Douglas K. Price, Cindy H. Chau, and William D. Figg
Mol. Pharmacol., Apr 2015; 87: 1006 - 1012.
8 Odyssey® Publications List – Cancer
Volume 6
A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation Koji Hatano, Binod Kumar, Yonggang Zhang, Jonathan B. Coulter, Mohammad Hedayati, Brian Mears, Xiaohua Ni, Tarana A. Kudrolli, Wasim H. Chowdhury, Ronald Rodriguez, Theodore L. DeWeese, and Shawn E. Lupold
Nucleic Acids Res., Apr 2015; 43: 4075 - 4086.
ERG Oncoprotein Inhibits ANXA2 Expression and Function in Prostate Cancer
Nicholas B. Griner, Denise Young, Pankaj Chaudhary, Ahmed A. Mohamed, Wei Huang, Yongmei Chen, Taduru Sreenath, Albert Dobi, Gyorgy Petrovics, Jamboor K. Vishwanatha, Isabell A. Sesterhenn, Shiv Srivastava, and Shyh-Han Tan
Mol. Cancer Res., Feb 2015; 13: 368 - 379.
Real-time, Near-Infrared Fluorescence Imaging with an Optimized Dye/Light Source/Camera Combination for Surgical Guidance of Prostate Cancer
Brian P. Neuman, John B. Eifler, Mark Castanares, Wasim H. Chowdhury, Ying Chen, Ronnie C. Mease, Rong Ma, Amarnath Mukherjee, Shawn E. Lupold, Martin G. Pomper, and Ronald Rodriguez
Clin. Cancer Res., Feb 2015; 21: 771 - 780.
Anticancer Activity of a Novel Selective CYP17A1 Inhibitor in Preclinical Models of CastrateResistant Prostate Cancer
Paul J. Toren, Soojin Kim, Steven Pham, Azzra Mangalji, Hans Adomat, Emma S. Tomlinson Guns, Amina Zoubeidi, William Moore, and Martin E. Gleave
Mol. Cancer Ther., Jan 2015; 14: 59 - 69.
Abstract 2152: Akt/survivin pathway inhibition synergizes the apoptotic cell death induced by A-santalol in prostate cancer cells
Ajay Bommareddy, Lauren Lockus, Jonathan Seward, William Eggelston, Stacy Prelewicz, Andrea Antal, Sarah Fillman, Christian Castro, Adam L. VanWert, Sreevidya Santha, and Chandradhar Dwivedi
Cancer Res., Oct 2014; 74: 2152.
Thyroid Cancer Glucose-deprivation increases thyroid cancer cells sensitivity to metformin
Athanasios Bikas, Kirk Jensen, Aneeta Patel, John Costello, Jr, Dennis McDaniel, Joanna Klubo-Gwiezdzinska, Olexander Larin, Victoria Hoperia, Kenneth D Burman, Lisa Boyle, Leonard Wartofsky, and Vasyl Vasko
Endocr. Relat. Cancer, Oct 2015; 22: 919 - 932.
Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment Ganesh Venkatraman, Matthew G. K. Benesch, Xiaoyun Tang, Jay Dewald, Todd P. W. McMullen, and David N. Brindley
FASEB J, Mar 2015; 29: 772 - 785.
Phosphoproteomics of MAPK Inhibition in BRAF-Mutated Cells and a Role for the Lethal Synergism of Dual BRAF and CK2 Inhibition Robert Parker, Roderick Clifton-Bligh, and Mark P. Molloy
Mol. Cancer Ther., Jul 2014; 13: 1894 - 1906.
Other Cancers Esophageal Squamous Cell Carcinoma Cells Modulate Chemokine Expression and Hyaluronan Synthesis in Fibroblasts Inga Kretschmer, Till Freudenberger, Sören Twarock, Yu Yamaguchi, Maria Grandoch, and Jens W. Fischer
J. Biol. Chem., Feb 2016; 291: 4091 - 4106.
EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes
Henar Hernando, Kathy A. Gelato, Ralf Lesche, Georg Beckmann, Silke Koehr, Saskia Otto, Patrick Steigemann, and Carlo Stresemann
Mol. Cancer Ther., Feb 2016; 15: 287 - 298.
A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3 Daniel J. Garama, Tiffany J. Harris, Christine L. White, Fernando J. Rossello, Maher Abdul-Hay, Daniel J. Gough, and David E. Levy
Mol. Cell. Biol., Nov 2015; 35: 3646 - 3656.
9 Odyssey® Publications List – Cancer
Volume 6
Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Ferdia A. Gallagher, Helen Sladen, Mikko I. Kettunen, Eva M. Serrao, Tiago B. Rodrigues, Alan Wright, Andrew B. Gill, Sarah McGuire, Thomas C. Booth, Joan Boren, Alan McIntyre, Jodi L. Miller, Shen-Han Lee, Davina Honess, Sam E. Day, De-En Hu, William J. Howat, Adrian L. Harris, and Kevin M. Brindle
Cancer Res., Oct 2015; 75: 4109 - 4118.
Glucose-deprivation increases thyroid cancer cells sensitivity to metformin
Athanasios Bikas, Kirk Jensen, Aneeta Patel, John Costello, Jr, Dennis McDaniel, Joanna Klubo-Gwiezdzinska, Olexander Larin, Victoria Hoperia, Kenneth D Burman, Lisa Boyle, Leonard Wartofsky, and Vasyl Vasko
Endocr. Relat. Cancer, Oct 2015; 22: 919 - 932.
Preclinical Validation of the Utility of BLZ-100 in Providing Fluorescence Contrast for Imaging Spontaneous Solid Tumors
Janean Fidel, Katie C. Kennedy, William S. Dernell, Stacey Hansen, Valorie Wiss, Mark R. Stroud, Joshua I. Molho, Sue E. Knoblaugh, Jeffrey Meganck, James M. Olson, Brad Rice, and Julia Parrish-Novak
Cancer Res., Oct 2015; 75: 4283 - 4291.
Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells Laura R. Wasil, Leizhen Wei, Christopher Chang, Li Lan, and Kathy H. Y. Shair
J. Virol., Aug 2015; 89: 7612 - 7624.
Safety and Tumor Specificity of Cetuximab-IRDye® 800 for Surgical Navigation in Head and Neck Cancer
Eben L. Rosenthal, Jason M. Warram, Esther de Boer, Thomas K. Chung, Melissa L. Korb, Margie Brandwein-Gensler, Theresa V. Strong, Cecelia E. Schmalbach, Anthony B. Morlandt, Garima Agarwal, Yolanda E. Hartman, William R. Carroll, Joshua S. Richman, Lisa K. Clemons, Lisle M. Nabell, and Kurt R. Zinn
Clin. Cancer Res., Aug 2015; 21: 3658 - 3666.
Prevalence and Functional Consequence of TP53 Mutations in Pediatric Adrenocortical Carcinoma: A Children’s Oncology Group Study Jonathan D. Wasserman, Ana Novokmet, Claudia Eichler-Jonsson, Raul C. Ribeiro, Carlos Rodriguez-Galindo, Gerard P. Zambetti, and David Malkin
J. Clin. Oncol., Feb 2015; 33: 602 - 609.
K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif Frederick D. Tsai, Mathew S. Lopes, Mo Zhou, Helen Court, Odis Ponce, James J. Fiordalisi, Jessica J. Gierut, Adrienne D. Cox, Kevin M. Haigis, and Mark R. Philips
PNAS, Jan 2015; 112: 779 - 784.
Intraoperative Tumor Imaging with Indocyanine Green in Head and Neck Cancer Patients Thomas K. Chung, Joy Kovar, Walter Bell, Margaret Brandwein-Gensler, and Eben L. Rosenthal
Otolaryngology -- Head and Neck Surgery, Sep 2014; 151: P58.
Angiogenesis Deficiency of IL-12p35 improves cardiac repair after myocardial infarction by promoting angiogenesis Xiaoyu Kan, Yina Wu, Youcai Ma, Congcong Zhang, Ping Li, Lifei Wu, Shuai Zhang, Yulin Li, and Jie Du
Cardiovasc Res, Feb 2016; 109: 249 - 259.
Pim1 kinase promotes angiogenesis through phosphorylation of endothelial nitric oxide synthase at Ser-633 Ming Chen, Bing Yi, Ni Zhu, Xin Wei, Guan-Xin Zhang, Shengdong Huang, and Jianxin Sun
Cardiovasc Res, Jan 2016; 109: 141 - 150.
IFN-β affects the angiogenic potential of circulating angiogenic cells by activating calpain 1
Cansu Yıldırım, Julie Favre, Ester M. Weijers, Ruud D. Fontijn, Michiel H. van Wijhe, Sandra J. van Vliet, Reinier A. Boon, Pieter Koolwijk, Tineke C. T. M. van der Pouw Kraan, and Anton J. G. Horrevoets
Am J Physiol Heart Circ Physiol, Nov 2015; 309: H1667 - H1678.
miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis Xiaojuan Sun, Cherie Charbonneau, Lei Wei, Qian Chen, and Richard M. Terek
Mol. Cancer Res., Sep 2015; 13: 1347 - 1357.
10 Odyssey® Publications List – Cancer
Volume 6
The Antiparasitic Drug, Potassium Antimony Tartrate, Inhibits Tumor Angiogenesis and Tumor Growth in Nonsmall-Cell Lung Cancer Beibei Wang, Weiwei Yu, Jiawei Guo, Xingwu Jiang, Weiqiang Lu, Mingyao Liu, and Xiufeng Pang
J. Pharmacol. Exp. Ther., Nov 2014; 352: 129 - 138.
TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells Marya Obeidat, Laiji Li, and Barbara J. Ballermann
Am J Physiol Renal Physiol, Sep 2014; 307: F623 - F633.
Apoptosis p52 Overexpression Increases Epithelial Apoptosis, Enhances Lung Injury, and Reduces Survival after Lipopolysaccharide Treatment Jamie A. Saxon, Dong-Sheng Cheng, Wei Han, Vasiliy V. Polosukhin, Allyson G. McLoed, Bradley W. Richmond, Linda A. Gleaves, Harikrishna Tanjore, Taylor P. Sherrill, Whitney Barham, Fiona E. Yull, and Timothy S. Blackwell
J. Immunol., Feb 2016; 196: 1891 - 1899.
Integrin αVβ5-mediated Removal of Apoptotic Cell Debris by the Eye Lens and Its Inhibition by UV Light Exposure Daniel Chauss, Lisa A. Brennan, Olga Bakina, and Marc Kantorow
J. Biol. Chem., Dec 2015; 290: 30253 - 30266.
Network-level effects of kinase inhibitors modulate TNF-α–induced apoptosis in the intestinal epithelium
Jessica J. Gierut, Levi B. Wood, Ken S. Lau, Yi-Jang Lin, Casie Genetti, Ahmed A. Samatar, Douglas A. Lauffenburger, and Kevin M. Haigis
Sci. Signal., Dec 2015; 8: ra129
Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis Mohammad Fallahi-Sichani, Nathan J Moerke, Mario Niepel, Tinghu Zhang, Nathanael S Gray, and Peter K Sorger
Mol Syst Biol, Mar 2015; 11: 797.
Marine Sponge Cribrochalina vasculum Compounds Activate Intrinsic Apoptotic Signaling and Inhibit Growth Factor Signaling Cascades in Non–Small Cell Lung Carcinoma
Ana Zovko, Kristina Viktorsson, Petra Hååg, Dimitry Kovalerchick, Katarina Färnegårdh, Andrea Alimonti, Micha Ilan, Shmuel Carmeli, and Rolf Lewensohn
Mol. Cancer Ther., Dec 2014; 13: 2941 - 2954.
Abstract 2152: Akt/survivin pathway inhibition synergizes the apoptotic cell death induced by A-santalol in prostate cancer cells
Ajay Bommareddy, Lauren Lockus, Jonathan Seward, William Eggelston, Stacy Prelewicz, Andrea Antal, Sarah Fillman, Christian Castro, Adam L. VanWert, Sreevidya Santha, and Chandradhar Dwivedi
Cancer Res., Oct 2014; 74: 2152.
Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy Nilay Nandi, Lauren K. Tyra, Drew Stenesen, and Helmut Krämer
J. Cell Biol., Oct 2014; 207: 253 - 268.
Autophagy FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy
Hallvard L. Olsvik, Trond Lamark, Kenji Takagi, Kenneth Bowitz Larsen, Gry Evjen, Aud Øvervatn, Tsunehiro Mizushima, and Terje Johansen
J. Biol. Chem., Dec 2015; 290: 29361 - 29374.
Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease
Min Peng, Julian Ostrovsky, Young Joon Kwon, Erzsebet Polyak, Joseph Licata, Mai Tsukikawa, Eric Marty, Jeffrey Thomas, Carolyn A. Felix, Rui Xiao, Zhe Zhang, David L. Gasser, Yair Argon, and Marni J. Falk
Hum. Mol. Genet., Sep 2015; 24: 4829 - 4847.
11 Odyssey® Publications List – Cancer
Volume 6
Monitoring Autophagic Flux by Using Lysosomal Inhibitors and Western Blotting of Endogenous MAP1LC3B Suganthi Chittaranjan, Svetlana Bortnik, and Sharon M. Gorski
Cold Spring Harb Protoc, Aug 2015; 2015: pdb.prot086256.
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics Szu-Yu Kuo, Adam B. Castoreno, Leslie N. Aldrich, Kara G. Lassen, Gautam Goel, Vlado Dancík, Petric Kuballa, Isabel Latorre, Kara L. Conway, Sovan Sarkar, Dorothea Maetzel, Rudolf Jaenisch, Paul A. Clemons, Stuart L. Schreiber, Alykhan F. Shamji, and Ramnik J. Xavier
PNAS, Aug 2015; 112: E4281 - E4287.
Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma Jordan Wengrod, Ding Wang, Sarah Weiss, Hua Zhong, Iman Osman, and Lawrence B. Gardner
Sci. Signal., Mar 2015; 8: ra27.
BPIFB3 Regulates Autophagy and Coxsackievirus B Replication through a Noncanonical Pathway Independent of the Core Initiation Machinery Elizabeth Delorme-Axford, Stefanie Morosky, Jennifer Bomberger, Donna B. Stolz, William T. Jackson, and Carolyn B. Coyne
mBio, Dec 2014; 5: e02147-14.
Metabolic-Stress-Induced Rearrangement of the 14-3-3V Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3V Interaction with Phosphorylated Atg9
Vajira K. Weerasekara, David J. Panek, David G. Broadbent, Jeffrey B. Mortenson, Andrew D. Mathis, Gideon N. Logan, John T. Prince, David M. Thomson, J. Will Thompson, and Joshua L. Andersen
Mol. Cell. Biol., Dec 2014; 34: 4379 - 4388.
Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy Nilay Nandi, Lauren K. Tyra, Drew Stenesen, and Helmut Krämer
J. Cell Biol., Oct 2014; 207: 253 - 268.
Cell Signaling / Signal Transduction Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization Tran Thi Hien, Karolina M. Turczynska, Diana Dahan, Mari Ekman, Mario Grossi, Johan Sjögren, Johan Nilsson, Thomas Braun, Thomas Boettger, Eliana Garcia-Vaz, Karin Stenkula, Karl Swärd, Maria F. Gomez, and Sebastian Albinsson
J. Biol. Chem., Feb 2016; 291: 3552 - 3568.
Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct
Mitsi A. Blount, Penelope Cipriani, Sara K. Redd, Ronald J. Ordas, Lauren N. Black, Diane L. Gumina, Carol A. Hoban, Janet D. Klein, and Jeff M. Sands
Am J Physiol Cell Physiol, Nov 2015; 309: C608 - C615.
The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα– and Extracellular Signal-Regulated Kinase 1/2–Dependent Mechanism Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J. López, Silvia Terés, Rafael Alvarez, María Alonso-Sande, Xavier Busquets, and Pablo V. Escribá
J. Pharmacol. Exp. Ther., Jul 2015; 354: 213 - 224.
PKCt interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels Ruifeng Lu, Dogukan Dalgalan, Edward K. Mandell, Sara S. Parker, Sourav Ghosh, and Jean M. Wilson
Mol. Biol. Cell, Apr 2015; 26: 1523 - 1531.
Systematic identification of signal integration by protein kinase A
Marie Filteau, Guillaume Diss, Francisco Torres-Quiroz, Alexandre K. Dubé, Andrea Schraffl, Verena A. Bachmann, Isabelle Gagnon-Arsenault, Andrée-Ève Chrétien, Anne-Lise Steunou, Ugo Dionne, Jacques Côté, Nicolas Bisson, Eduard Stefan, and Christian R. Landry
PNAS, Apr 2015; 112: 4501 - 4506.
12 Odyssey® Publications List – Cancer
Volume 6
Cannabinoid Receptor–Interacting Protein 1a Modulates CB1 Receptor Signaling and Regulation Tricia H. Smith, Lawrence C. Blume, Alex Straiker, Jordan O. Cox, Bethany G. David, Julie R. Secor McVoy, Katherine W. Sayers, Justin L. Poklis, Rehab A. Abdullah, Michaela Egertová, Ching-Kang Chen, Ken Mackie, Maurice R. Elphick, Allyn C. Howlett, and Dana E. Selley
Mol. Pharmacol., Mar 2015; 87: 747 - 765.
G protein βg subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway S. Malik, R. G. deRubio, M. Trembley, R. Irannejad, P. B. Wedegaertner, and A. V. Smrcka
Mol. Biol. Cell, Mar 2015; 26: 1188 – 1198
PKA-Dependent Phosphorylation of Ribosomal Protein S6 Does Not Correlate with Translation Efficiency in Striatonigral and Striatopallidal Medium-Sized Spiny Neurons Anne Biever, Emma Puighermanal, Akinori Nishi, Alexandre David, Claire Panciatici, Sophie Longueville, Dimitris Xirodimas, Giuseppe Gangarossa, Oded Meyuhas, Denis Hervé, Jean-Antoine Girault, and Emmanuel Valjent
J. Neurosci., Mar 2015; 35: 4113 - 4130.
PKCd is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages Katka Szilagyi, Alexander B. Meijer, Annette E. Neele, Paul Verkuijlen, Michael Leitges, Sandrine Dabernat, Elisabeth Förster-Waldl, Kaan Boztug, Alexandre Belot, Taco W. Kuijpers, Georg Kraal, Menno P. J. de Winther, and Timo K. van den Berg
Cardiovasc Res, Dec 2014; 104: 467 - 476.
Invasion / Metastasis Cellular Mechanisms Underlying Complete Hematological Response of Chronic Myeloid Leukemia to BRAF and MEK1/2 Inhibition in a Patient with Concomitant Metastatic Melanoma Miles C. Andrews, Natalie Turner, Janis Boyd, Andrew W. Roberts, Andrew P. Grigg, Andreas Behren, and Jonathan Cebon
Clin. Cancer Res., Dec 2015; 21: 5222 - 5234.
Antioxidants can increase melanoma metastasis in mice
Kristell Le Gal, Mohamed X. Ibrahim, Clotilde Wiel, Volkan I. Sayin, Murali K. Akula, Christin Karlsson, Martin G. Dalin, Levent M. Akyürek, Per Lindahl, Jonas Nilsson, and Martin O. Bergo
Science Translational Medicine, Oct 2015; 7: 308re8.
α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3 Nikki R. Paul, Jennifer L. Allen, Anna Chapman, Maria Morlan-Mairal, Egor Zindy, Guillaume Jacquemet, Laura Fernandez del Ama, Nermina Ferizovic, David M. Green, Jonathan D. Howe, Elisabeth Ehler, Adam Hurlstone, and Patrick T. Caswell
J. Cell Biol., Sep 2015; 210: 1013 - 1031.
miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis Xiaojuan Sun, Cherie Charbonneau, Lei Wei, Qian Chen, and Richard M. Terek
Mol. Cancer Res., Sep 2015; 13: 1347 - 1357.
Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis Min-chul Kwon, Natalie Proost, Ji-Ying Song, Kate D. Sutherland, John Zevenhoven, and Anton Berns
Genes & Dev., Aug 2015; 29: 1587 - 1592.
SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis
Patricia Dillenburg-Pilla, Vyomesh Patel, Constantinos M. Mikelis, Carlos Rodrigo Zárate-Bladés, Colleen L. Doci, Panomwat Amornphimoltham, Zhiyong Wang, Daniel Martin, Kantima Leelahavanichkul, Robert T. Dorsam, Andrius Masedunskas, Roberto Weigert, Alfredo A. Molinolo, and J. Silvio Gutkind
FASEB J, Mar 2015; 29: 1056 - 1068.
Transcriptome-wide Landscape of Pre-mRNA Alternative Splicing Associated with Metastatic Colonization Zhi-xiang Lu, Qin Huang, Juw Won Park, Shihao Shen, Lan Lin, Collin J. Tokheim, Michael D. Henry, and Yi Xing
Mol. Cancer Res., Feb 2015; 13: 305 - 318.
13 Odyssey® Publications List – Cancer
Volume 6
Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer Cells via Src-Focal Adhesion Kinase and Forkhead Box Protein M1 Eduardo Sanabria-Figueroa, Siobhan M. Donnelly, Kevin C. Foy, Meghan C. Buss, Robert C. Castellino, Elisavet Paplomata, Latonia Taliaferro-Smith, Pravin T.P. Kaumaya, and Rita Nahta
Mol. Pharmacol., Dec 2014; 87: 150 - 161.
TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion Lukas D. Osborne, George Z. Li, Tam How, E. Tim O’Brien, Gerard C. Blobe, Richard Superfine, and Karthikeyan Mythreye
Mol. Biol. Cell, Nov 2014; 25: 3528 - 3540.
MMP Amyloid β Oligomers Disrupt Blood–CSF Barrier Integrity by Activating Matrix Metalloproteinases Marjana Brkic, Sriram Balusu, Elien Van Wonterghem, Nina Gorlé, Iryna Benilova, Anna Kremer, Inge Van Hove, Lieve Moons, Bart De Strooper, Selma Kanazir, Claude Libert, and Roosmarijn E. Vandenbroucke
J. Neurosci., Sep 2015; 35: 12766 - 12778.
Expression of Matrix Metalloproteinase (MMP)-20 and Potential Interaction with Dentin Sialophosphoprotein (DSPP) in Human Major Salivary Glands Komal Koli, Geetu Saxena, and Kalu U. E. Ogbureke
Journal of Histochemistry & Cytochemistry, Jul 2015; 63: 524 - 533.
Cytokine-induced monocyte MMP-1 is negatively regulated by GSK-3 through a p38 MAPK-mediated decrease in ERK1/2 MAPK activation Yahong Zhang and Larry M. Wahl
J. Leukoc. Biol., May 2015; 97: 921 - 927.
Matrix Metalloproteinase 20–Dentin Sialophosphoprotein Interaction in Oral Cancer G. Saxena, K. Koli, J. de la Garza, and K.U.E. Ogbureke
Journal of Dental Research, Apr 2015; 94: 584 - 593.
FOXA2 suppresses the metastasis of hepatocellular carcinoma partially through matrix metalloproteinase-9 inhibition
Jian Wang, Chang-Peng Zhu, Ping-Fang Hu, Hui Qian, Bei-Fang Ning, Qing Zhang, Fei Chen, Jiao Liu, Bin Shi, Xin Zhang, and Wei-Fen Xie
Carcinogenesis, Nov 2014; 35: 2576 - 2583.
MCP-1 downregulates MMP-9 export via vesicular redistribution to lysosomes in rat portal fibroblasts
DaShawn A. Hickman, Gaurav Syal, Michel Fausther, Elise G. Lavoie, Jessica R. Goree, Brian Storrie, and Jonathan A. Dranoff
PHY2, Nov 2014; 2: e12153.
MicroRNA / miRNA / siRNA / RNAi FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-β signaling Ana C. P. Correia, Jan-Renier A. J. Moonen, Marja G. L. Brinker, and Guido Krenning
J. Cell Sci., Feb 2016; 129: 569 - 579.
Enhancing potency of siRNA targeting fusion genes by optimization outside of target sequence Kseniya Gavrilov, Young-Eun Seo, Gregory T. Tietjen, Jiajia Cui, Christopher J. Cheng, and W. Mark Saltzman
PNAS, Dec 2015; 112: E6597 - E6605.
eIF4AII is dispensable for miRNA-mediated gene silencing Gabriela Galicia-Vázquez, Jennifer Chu, and Jerry Pelletier
RNA, Oct 2015; 21: 1826 - 1833.
14 Odyssey® Publications List – Cancer
Volume 6
Characterization of the Tyrosine Kinase-Regulated Proteome in Breast Cancer by Combined use of RNA interference (RNAi) and Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) Quantitative Proteomics Justin Stebbing, Hua Zhang, Yichen Xu, Arnhild Grothey, Paul Ajuh, Nicos Angelopoulos, and Georgios Giamas
Mol. Cell. Proteomics, Sep 2015; 14: 2479 - 2492.
Specific miRNA and its target in neutrophils after traumatic injury Jun Yang, Huazhong Han, Yijun Zhao, and Huanlong Qin
Acta Biochim Biophys Sin, Sep 2015; 47: 749 - 754.
General and MicroRNA-Mediated mRNA Degradation Occurs on Ribosome Complexes in Drosophila Cells Sanja Antic, Michael T. Wolfinger, Anna Skucha, Stefanie Hosiner, and Silke Dorner
Mol. Cell. Biol., Jul 2015; 35: 2309 - 2320.
A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation Koji Hatano, Binod Kumar, Yonggang Zhang, Jonathan B. Coulter, Mohammad Hedayati, Brian Mears, Xiaohua Ni, Tarana A. Kudrolli, Wasim H. Chowdhury, Ronald Rodriguez, Theodore L. DeWeese, and Shawn E. Lupold
Nucleic Acids Res., Apr 2015; 43: 4075 - 4086.
A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer Shane Stegeman, Leire Moya, Luke A Selth, Amanda B Spurdle, Judith A Clements, and Jyotsna Batra
Endocr. Relat. Cancer, Mar 2015; 22: 265 - 276.
Pan-viral-microRNA screening identifies interferon inhibition as a common function of diverse viruses Jennifer E. Cox, Lydia V. McClure, Andrei Goga, and Christopher S. Sullivan
PNAS, Feb 2015; 112: 1856 – 1861.
A dsRNA-binding protein of a complex invertebrate DNA virus suppresses the Drosophila RNAi response Alfred W. Bronkhorst, Koen W.R. van Cleef, Hanka Venselaar, and Ronald P. van Rij
Nucleic Acids Res., Oct 2014; 42: 12237 - 12248.
PTEN Discovery and functional characterization of a neomorphic PTEN mutation
Helio A. Costa, Michael G. Leitner, Martin L. Sos, Angeliki Mavrantoni, Anna Rychkova, Jeffrey R. Johnson, Billy W. Newton, Muh-Ching Yee, Francisco M. De La Vega, James M. Ford, Nevan J. Krogan, Kevan M. Shokat, Dominik Oliver, Christian R. Halaszovich, and Carlos D. Bustamante
PNAS, Nov 2015; 112: 13976 - 13981.
Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration Maria B. Goncalves, Tony Malmqvist, Earl Clarke, Chantal J. Hubens, John Grist, Carl Hobbs, Diogo Trigo, Mårten Risling, Maria Angeria, Peter Damberg, Thomas P. Carlstedt, and Jonathan P.T Corcoran
J. Neurosci., Nov 2015; 35: 15731 - 15745.
TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells Marya Obeidat, Laiji Li, and Barbara J. Ballermann
Am J Physiol Renal Physiol, Sep 2014; 307: F623 - F633.
Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth
Hung-En Hsia, Rohit Kumar, Rossella Luca, Michiko Takeda, Julien Courchet, Jonathan Nakashima, Shumin Wu, Sandra Goebbels, Wenlin An, Britta J. Eickholt, Franck Polleux, Daniela Rotin, Hong Wu, Moritz J. Rossner, Claudia Bagni, Jeong-Seop Rhee, Nils Brose, and Hiroshi Kawabe
PNAS, Sep 2014; 111: 13205 - 13210.
15 Odyssey® Publications List – Cancer
Volume 6
Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles Marie McLaughlin, Hazel L. Kinnell, Richard A. Anderson, and Evelyn E. Telfer
Mol. Hum. Reprod., Aug 2014; 20: 736 - 744.
Telomerase / Telomere Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae Hannah Kaizer, Carla J. Connelly, Kelsey Bettridge, Christopher Viggiani, and Carol W. Greider
Genetics, Oct 2015; 201: 573 - 586.
Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle Jacob M. Vogan and Kathleen Collins
J. Biol. Chem., Aug 2015; 290: 21320 - 21335.
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells
John Ramunas, Eduard Yakubov, Jennifer J. Brady, Stéphane Y. Corbel, Colin Holbrook, Moritz Brandt, Jonathan Stein, Juan G. Santiago, John P. Cooke, and Helen M. Blau
FASEB J, May 2015; 29: 1930 - 1939.
Therapy / Trials Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine Eric C. Cheung, Pearl Lee, Fatih Ceteci, Colin Nixon, Karen Blyth, Owen J. Sansom, and Karen H. Vousden
Genes & Dev., Jan 2016; 30: 52 - 63.
In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy Rama K. Mishra, Changyong Wei, Richard C. Hresko, Richa Bajpai, Monique Heitmeier, Shannon M. Matulis, Ajay K. Nooka, Steven T. Rosen, Paul W. Hruz, Gary E. Schiltz, and Mala Shanmugam
J. Biol. Chem., Jun 2015; 290: 14441 - 14453.
MiR-1188 at the imprinted Dlk1-Dio3 domain acts as a tumor suppressor in hepatoma cells Wei Cui, Zhijun Huang, Hongjuan He, Ning Gu, Geng Qin, Jie Lv, Tao Zheng, Kenkichi Sugimoto, and Qiong Wu
Mol. Biol. Cell, Apr 2015; 26: 1416 - 1427.
Suberoylanilide Hydroxamic Acid (SAHA)-Induced Dynamics of a Human Histone Deacetylase Protein Interaction Network Mihaela E. Sardiu, Karen T. Smith, Brad D. Groppe, Joshua M. Gilmore, Anita Saraf, Rhonda Egidy, Allison Peak, Chris W. Seidel, Laurence Florens, Jerry L. Workman, and Michael P. Washburn
Mol. Cell. Proteomics, Nov 2014; 13: 3114 - 3125.
Docetaxel induces moderate ovarian toxicity in mice, primarily affecting granulosa cells of early growing follicles Federica Lopes, Rowena Smith, Richard A. Anderson, and Norah Spears
Mol. Hum. Reprod., Oct 2014; 20: 948 - 959.
Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis Yuanbo Zhao, Beiqi Hongdu, Dalong Ma, and Yingyu Chen
Acta Biochim Biophys Sin, Aug 2014; 46: 668 - 674.
Network quantification of EGFR signaling unveils potential for targeted combination therapy
Bertram Klinger, Anja Sieber, Raphaela Fritsche-Guenther, Franziska Witzel, Leanne Berry, Dirk Schumacher, Yibing Yan, Pawel Durek, Mark Merchant, Reinhold Schäfer, Christine Sers, and Nils Blüthgen
Mol Syst Biol, Jul 2014; 9: 673.
16 Odyssey® Publications List – Cancer
Volume 6
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