2

Objectives › Discuss

An Overview of Metabolic Syndrome Stephanie Blackburn, MHS, MLS(ASCP)CM

metabolic syndrome and its impact on overall health › Assess laboratory findings associated with metabolic syndrome › Relate metabolic syndrome with chronic disease

1

3

“Metabolic”

“Syndrome”

Refers to biochemical processes involved in the body’s normal functioning

Pattern of symptoms that together are characteristic of a specific disorder or disease

4

Metabolic Syndrome Collection of cardiovascular risk factors that accelerate the onset of heart disease, stroke, and Type 2 diabetes mellitus

5

6

Leading causes of death (CDC) According to National Heart, Lung, and Blood Institute, “ a person with metabolic syndrome is twice as likely to develop heart disease and five times as likely to develop diabetes as someone without metabolic syndrome”

1.  2.  3.  4.  5.  6.  7. 

Heart disease Cancer Chronic lower respiratory disease Accident Stroke Alzheimer’s disease Diabetes

http://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm

1  

7

History of Metabolic Syndrome › Risk

factors for diabetes observed in 1920s

› “Metabolic

1950s

› Better

syndrome” coined in

8

1947

Atherosclerosis

Gout

Upper body obesity

Diabetes

understood in 1970s Kidney stones

9

Early 1950s

10

1977 – Metabolic Syndrome › Term

Lowcalorie diet

described association between obesity, diabetes mellitus, high triglycerides, high uric acid, and fatty liver disease

Improvements: Diabetes

› Combination

à increased risk for atherosclerosis

Cholesterol Lowcarb diet

Triglycerides

› Later,

described association between hyperlipidemia, obesity, gout, diabetes, and hypertension

11

1978

Metabolic Syndrome

› Combination

of risk factors for myocardial infarction & obesity › Described

risk factors as “constellation abnormalities” › Glucose

intolerance

› Hyperinsulinemia › High

triglycerides glucose › High cholesterol › High

12

Dysmetabolic syndrome Hypertriglyceridemic waist Insulin resistance syndrome Obesity syndrome Syndrome X

2  

13

14

“Syndrome”

Who is at risk?

› Cluster

Posses at least 3 of the following: › Central obesity

of conditions that occur together

› Men

› Metabolic

waist: >40 in. waist: >35 in.

› Women

syndrome

› Triglycerides:

≥ 150 mg/dl