2016

NUTRICIA PRODUCT REFERENCE GUIDE FOR CLINICIANS

•

CANADA

Nutricia Contacts

How to Contact Nutricia

My Nutricia sales representative(s): Name:...............................................................................

Nutricia’s Customer Service: • Phone: (877) 636-2283

Phone:..............................................................................

Nutricia’s Nutrition Services:

Email:................................................................................

• Phone: (877) 636-2283 – Option 2 • Email: [email protected]

Name:............................................................................... Phone:.............................................................................. Email:................................................................................

Name:............................................................................... Phone:..............................................................................

Nutricia Metabolics: • Phone: (800) 605-0410 • Email: [email protected] Internet: For information on Nutricia products and other helpful resources, visit www.Nutricia-NA.com. For a complete listing of our websites, see pages 202. You may also visit our Neocate website at www.Neocate.com/Canada or our Metabolics website at www.MedicalFood.com.

Email:................................................................................

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© 2016 Nutricia North America. All rights reserved. Nutricia and its brands are registered trademarks. See product labels for more specifics.

• Nutricia is a Global Health Company • Nutricia Leads the Development and Use of Advanced Medical Nutrition for Specialized Care

• Nutricia Products and Services Transform the Daily Lives of Millions of Infants, Children, Adults and Aging Seniors

This guide is a convenient reference for clinicians to the full range of Nutricia’s medical nutritional products. Nutricia strives to develop quality products that offer choice and flexibility to today’s patients to enhance diet acceptance. Please note that all of our products require medical supervision. For additional information, please call our Nutrition Services team or visit our web sites at www.Nutricia-NA.com, www.Neocate.com/Canada or www. MedicalFood.com. Our staff is comprised of individuals with the highest level of expertise ready to offer support and reliability to our customers. We look forward to hearing from you.

Consumers and Patients: Nutricia products are available for convenient home delivery directly from Nutricia North America. Consumers can call our toll free number or visit one of our websites. See pages 232-233 for a list of our websites. Consumers can also purchase Nutricia products through retail pharmacies. Pharmacies can special order Nutricia products from their wholesaler or directly from Nutricia North America. 3

CONTENTS – Alphabetical Index

CONTENTS Ordering Information....................................................... 2-3 Contents by Product Indications..................................... 6-8 Specialized Pediatrics Section...................................... 9-34 Mixing Instructions................................................ 22-23 Household Measurements......................................... 24 Volume Prescription................................................... 25 Dilution Charts...................................................... 26-33 Metabolics Section................................................... 35-158 Household Measurements: Metabolics..................... 144 Mixing Instructions: Metabolics......................... 146-157 Low Protein Foods Section..................................... 159-162 Neurology Section.................................................. 163-172 Directions for Preparation: KetoCal........................... 170 Other Medical Nutritionals Section.......................... 173-190 Resources.............................................................. 191-202

Specialized Pediatrics page 9-34

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Metabolics

Low Protein Foods

page 35-158

page 159-162

Neurology page 163-172

Other Nutritionals page 173-190



Periflex Advance...............................................................40 Complete Amino Acid Mix...............................................184 Periflex Infant....................................................................36 Complex Essential MSD Drink Mix....................................80 PKU Periflex Junior Plus....................................................38 Complex Junior MSD Drink Mix.........................................78 Periflex LQ........................................................................42 Complex MSD Amino Acid Bars........................................84 PhenylAde 40 Drink Mix....................................................48 Complex MSD Amino Acid Blend......................................82 PhenylAde 60 Drink Mix....................................................50 Duocal............................................................................180 PhenylAde Amino Acid Bars..............................................54 Essential Amino Acid Mix................................................186 PhenylAde Amino Acid Blends..........................................52 GlutarAde GA-1 Amino Acid Blend..................................106 PhenylAde Essential Drink Mix...........................................44 GlutarAde Essential GA-1 Drink Mix................................104 PhenylAde GMP Drink Mix................................................46 GlutarAde Junior GA-1 Drink Mix....................................102 PhenylAde PheBLOC LNAA..............................................56 HCU Anamix Next...........................................................110 Phlexy-10 Drink Mix..........................................................66 HCU Lophlex LQ.............................................................116 Phlexy-Vits......................................................................188 IVA Anamix Next...............................................................90 PKU Lophlex LQ...............................................................62 KetoCal 4:1 LQ - Vanilla and Unflavoured........................168 Polycal............................................................................182 KetoCal 4:1 Powder........................................................164 TYR Anamix Next............................................................130 KetoCal 4:1 Powder - Coming Soon...............................166 TYR Lophlex LQ..............................................................138 Lanaflex............................................................................68 UCD Anamix Junior.........................................................140 Liquigen..........................................................................178 XLeu Analog......................................................................88 Lophlex Powder................................................................64 XLeu Maxamaid................................................................92 Low Protein Foods...................................................159-162 XLeu Maxamum................................................................94 Methionaid......................................................................118 XLys, XTrp Analog.............................................................96 Milupa lp-foods...............................................................160 XLys, XTrp Maxamaid........................................................98 MMA/PA Anamix Next.....................................................122 XLys, XTrp Maxamum......................................................100 Monogen........................................................................174 XMet Analog...................................................................108 Monogen - Coming Soon................................................176 XMet Maxamaid..............................................................112 MSUD Aid.........................................................................86 XMet Maxamum..............................................................114 MSUD Analog ..................................................................70 XMTVI Analog.................................................................120 MSUD Lophlex LQ............................................................76 XMTVI Maxamaid............................................................124 MSUD Maxamaid..............................................................72 XMTVI Maxamum............................................................126 MSUD Maxamum..............................................................74 XPhe Maxamaid................................................................58 Neocate E028 Splash.......................................................20 XPhe Maxamum................................................................60 Neocate DHA & ARA Infant Formula..................................10 XPhe, XTyr Analog...........................................................128 Neocate Junior..................................................................14 XPhe, XTyr Maxamaid.....................................................132 Neocate Junior with Prebiotic Fibre...................................16 XPHEN, TYR Maxamaid..................................................134 Neocate Nutra...................................................................12 XPHEN, TYR Maxamum..................................................136 Neocate Splash, Unflavoured............................................18 5

CONTENTS – By Indication and Diet Need* Allergy, Cow and Soy Milk/Multiple Food Protein Intolerance

Failure-to-Thrive

Duocal..................................................................... 180 Neocate E028 Splash................................................ 20 Neocate DHA & ARA Infant Formula........................... 10 Neocate Nutra............................................................ 12 Neocate Junior........................................................... 14 Neocate Junior with Prebiotic Fibre............................ 16 Neocate Splash, Unflavoured..................................... 18 Complete Amino Acid Mix........................................ 184

Duocal..................................................................... 180 Neocate E028 Splash................................................ 20 Neocate DHA & ARA Infant Formula........................... 10 Neocate Nutra............................................................ 12 Neocate Junior........................................................... 14 Neocate Junior with Prebiotic Fibre............................ 16 Neocate Splash.......................................................... 18 Polycal..................................................................... 182

Amino Acid-Based Products

Gastrointestinal Tract Impairment/GER



Neocate E028 Splash................................................ 20 Neocate DHA & ARA Infant Formula........................... 10 Neocate Nutra............................................................ 12 Neocate Junior........................................................... 14 Neocate Junior with Prebiotic Fibre............................ 16 Neocate Splash, Unflavoured..................................... 18 Nutricia Metabolic Formulas................................ 35-158 Complete Amino Acid Mix........................................ 184 Essential Amino Acid Mix......................................... 186 Single Amino Acids.................................................. 190

Chylothorax

Liquigen................................................................... 178 Monogen................................................................. 174 Eosinophilic Esophagitis (EoE)



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Neocate E028 Splash................................................ 20 Neocate DHA & ARA Infant Formula........................... 10 Neocate Nutra............................................................ 12 Neocate Junior........................................................... 14 Neocate Junior with Prebiotic Fibre............................ 16 Neocate Splash, Unflavoured..................................... 18 Complete Amino Acid Mix........................................ 184



Neocate E028 Splash................................................ 20 Neocate DHA & ARA Infant Formula........................... 10 Neocate Nutra............................................................ 12 Neocate Junior........................................................... 14 Neocate Junior with Prebiotic Fibre............................ 16 Neocate Splash.......................................................... 18 Pepdite Junior............................................................ 22 Complete Amino Acid Mix........................................ 184

Glutaric Acidemia Type I



GlutarAde Junior GA-1 Drink Mix............................. 102 GlutarAde Essential GA-1 Drink Mix......................... 104 GlutarAde GA-1 Amino Acid Blend........................... 106 XLys, XTrp Analog...................................................... 96 XLys, XTrp Maxamaid................................................. 98 XLys, XTrp Maxamum............................................... 100

Homocystinuria/Hypermethioninemia



XMet Analog............................................................ 108 XMet Maxamaid....................................................... 112 XMet Maxamum....................................................... 114 HCU Anamix Next.................................................... 110 HCU Lophlex LQ...................................................... 116 Milupa lp-foods........................................................ 160

Inborn Errors of Metabolism

Nutricia Metabolic Formulas...............................35-158 Low Protein Foods...........................................160-161 Liquigen.................................................................. 178 Monogen................................................................ 174 Duocal.................................................................... 180 Polycal.................................................................... 182 Complete Amino Acid Mix....................................... 184 Essential Amino Acid Mix........................................ 186 Phlexy-Vits.............................................................. 188 Single Amino Acids................................................. 190 Isovaleric Acidemia



IVA Anamix Next....................................................... 90 XLeu Analog.............................................................. 88 XLeu Maxamaid........................................................ 92 XLeu Maxamum........................................................ 94

Ketogenic Diet

KetoCal 4:1 LQ - Vanilla and Unflavoured................ 168 KetoCal 4:1 Powder................................................ 174 Liquigen.................................................................. 178 Long Chain Fatty Acid Oxidation Disorders

Liquigen.................................................................. 178 Monogen................................................................ 174 Low Protein Diets

Low Protein Foods...........................................160-161 Duocal.................................................................... 180 Malabsorption

Duocal.................................................................... 180 Neocate DHA & ARA Infant Formula.......................... 10 Neocate Nutra........................................................... 12 Neocate Junior.......................................................... 14 Neocate Junior with Prebiotic Fibre........................... 16 Neocate Splash, Unflavoured.................................... 18 Liquigen.................................................................. 178 Polycal.................................................................... 182 Complete Amino Acid Mix....................................... 184

Maple Syrup Urine Disease



Complex Junior MSD Drink Mix................................. 78 Complex Essential MSD Drink Mix............................ 80 Complex MSD Amino Acid Bars................................ 84 MSUD Analog........................................................... 70 MSUD Maxamaid...................................................... 72 MSUD Maxamum...................................................... 74 MSUD Lophlex LQ.................................................... 76 MSUD Aid................................................................. 86

Modular Diets

Duocal.................................................................... 180 Liquigen.................................................................. 178 Polycal.................................................................... 182 Complete Amino Acid Mix....................................... 184 Essential Amino Acid Mix........................................ 186 Phlexy-Vits.............................................................. 188 Phenylketonuria

Periflex Infant............................................................ 36 PKU Periflex Junior Plus............................................ 38 Periflex LQ................................................................ 42 Periflex Advance....................................................... 40 PhenylAde 40 Drink Mix............................................ 48 PhenylAde 60 Drink Mix............................................ 50 PhenylAde Amino Acid Bars...................................... 54 PhenylAde Amino Acid Blends.................................. 52 PhenylAde Essential Drink Mix................................... 44 PhenylAde GMP Drink Mix........................................ 46 PhenylAde PheBLOC LNAA...................................... 56 XPhe Maxamaid........................................................ 58 XPhe Maxamum Powder........................................... 60 Lophlex Powder........................................................ 64 Phlexy-10 Drink Mix.................................................. 66 PKU Lophlex LQ....................................................... 62 Lanaflex.................................................................... 68 Propionic/Methylmalonic Acidemia



MMA/PA Anamix Next............................................. 122 XMTVI Analog......................................................... 120 XMTVI Maxamaid.................................................... 124 XMTVI Maxamum.................................................... 126 *Not a complete listing

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Protein-Energy Malnutrition (PEM)

Duocal.................................................................... 180 Polycal.................................................................... 182 Renal Failure

Low Protein Foods...........................................160-161 Duocal.................................................................... 180 Polycal.................................................................... 182 Short Bowel Syndrome

Liquigen.................................................................. 178 Neocate E028 Splash............................................... 20 Neocate DHA & ARA Infant Formula.......................... 10 Neocate Nutra........................................................... 12 Neocate Junior.......................................................... 14 Neocate Junior with Prebiotic Fibre........................... 16 Neocate Splash, Unflavoured.................................... 18 Complete Amino Acid Mix....................................... 184 Tyrosinemia



XPhe, XTyr Analog................................................... 128 XPhe, XTyr Maxamaid............................................. 132 XPHEN, TYR Maxamaid.......................................... 134 XPHEN, TYR Maxamum.......................................... 136 TYR Anamix Next.................................................... 130 TYR Lophlex LQ...................................................... 138

Unintentional Weight Loss

Duocal.................................................................... 180 Urea Cycle Disorders



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UCD Anamix Junior................................................. 140 Essential Amino Acid Mix........................................ 186

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Specialized Pediatrics

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A nutritionally complete, powdered amino acid-based infant formula containing iron and DHA and ARA.

Nutrition Information: Nutrients Energy , kcal (kJ)

67.0 (279)

Minerals

Per 100 mL

522

82.5

392

61.9

13.0

2.1

Phosphorus, mg

49.3

7.8

Magnesium, mg

Fat, g

19.1

3.0

2.9

0.45

346

Per 100 g

Calcium, mg

Carbohydrate, g

a-Linolenic Acid, mg

Specialized Pediatrics

421 (1766)

Ingredients:

Per 100 mL

Protein Equivalent, g

Linoleic Acid, g

10

Per 100 g

52.0

8.2

Iron, mg

7.8

1.2

Zinc, mg

7.0

1.1

55.0

Manganese, mg

0.380

0.060

Main Features:

Indications:

Arachidonic Acid, mg

63.7

10.1

Copper, mg

0.520

0.0822

• Hypoallergenic • With DHA and ARA • 100% non-allergenic free amino acids • Nutritionally complete • Over 100 publications and counting support Neocate • Standard dilution = 0.67 kcal/mL • Osmolality (at 0.67 kcal/mL): 375 mOsm/kg • Energy distribution: Protein 12% Carbohydrate 47% Fat (MCT 33% / LCT 67%) 41% • Displacement 0.7 mL/g

• • •

Docosahexaenoic Acid, mg 36.4

5.8

Iodine, mg

0.0650

0.0103

Ash, mg

0.54

Molybdenum, mg

0.020

0.0032

Vitamins Chromium, mg

0.0150

0.0024

Vitamin A, IU

1648

0.0157

Vitamin D3, IU

252

Cow milk allergy and soy milk allergy Multiple food protein intolerance Food allergy associated conditions: • Short bowel syndrome (SBS) • Eosinophilic esophagitis (EoE) • Malabsorption • Gastroesophageal reflux • Other GI disorders

3.4

260 39.8

4.8

0.76

Potassium, mg

653

0.0370

0.0058

Chloride, mg

325

Thiamine, mg

0.31

0.05 0.09

0.58

Vitamin B6, mg

0.52

0.08

Vitamin B12, mg

0.0011

0.0002

For guidance on monitoring micronutrients, please see page 34.

Niacin, mg

6.5

1.0

Folic Acid, mg

0.0430

0.0068

Pantothenic Acid, mg

2.6

0.41

Ordering Information:

Biotin, mg

0.0130

0.0021

Calories Per Can 1684

157

Vitamin K1, IU Riboflavin, mg

Product Packaging 4 x 400 g

Sodium, mg

Vitamin E, IU

For details on administration and household measurements, please see pages 22-33.

Product Code 60722

Selenium, mg

Vitamin C, mg

39.0

Choline, mg

55.0

8.7

Inositol, mg

98.0

15.5

0.0025 24.8 103 51.4

Corn Syrup Solids, Refined Vegetable Oil (Modified Coconut and/or Palm Kernel Oil (Medium Chain Triglycerides), High Oleic Sunflower Oil, Soy Oil), Calcium Phosphate, L-Arginine L-Aspartate, Tripotassium Citrate, L-Leucine, L-Lysine Acetate, L-Glutamine, L-Proline, L-Valine, Glycine, L-Isoleucine, Citric Acid Esters of Mono- and Diglycerides, L-Threonine, L-Phenylalanine, L-Tyrosine, L-Serine, L-Histidine, L-Alanine, Sodium Chloride, L-Cystine, L-Tryptophan, L-Methionine, Magnesium Acetate, Magnesium L-Aspartate, Potassium Chloride, Mortierella Alpina Oil*, Choline Bitartrate, Inositol, Crypthecodinium Cohnii Oil**, Ascorbic Acid (Vitamin C), Ferrous Sulfate, Zinc Sulfate, Taurine, L-Carnitine, Sunflower Oil, Niacinamide, DL-α-Tocopheryl Acetate (Vitamin E), Calcium D-Pantothenate, Cupric Sulfate, Manganese Sulfate, Pyridoxine Hydrochloride, Riboflavin, Vitamin A Acetate, Thiamine Chloride Hydrochloride, Ascorbyl Palmitate, Potassium Iodide, Chromium Sulfate, Mixed Tocopherols, DL-α-Tocopherol (Vitamin E), Phylloquinone (Vitamin K1), Sodium Molybdate, Folic Acid, Sodium Hydrogen Selenite, Biotin, Cholecalciferol (Vitamin D3), Cyanocobalamin (Vitamin B12).

Neocate DHA & ARA Infant Formula

Neocate® DHA & ARA Infant Formula

* A Source of Arachidonic Acid (ARA) ** A Source of Docosahexaenoic Acid (DHA)

6.2

* Standard Dilution = .67 kcal/mL

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Neocate Nutra

Specialized Pediatrics

The first and only amino acid-based semi-solid food for special medical purpose for children and infants over 6 months of age.

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Main Features:

Indications:

• Smooth, spoonable consistency • Hypoallergenic • Made with 100% non-allergenic amino acids • Milk protein- and gluten-free • High in calcium, vitamin D, zinc and iron • Free from artificial flavours, colours and preservatives • Energy distribution: Protein 7% Carbohydrate 57% Fat (MCT 4% / LCT 96%) 36%

• • •

Cow milk allergy and soy milk allergy Multiple food protein intolerance Food allergy-associated conditions: • Short bowel syndrome (SBS) • Eosinophilic esophagitis (EoE) • Malabsorption • Gastroesophageal reflux • Other GI disorders

For details on administration and household measurements, please see pages 22-33.

Ordering Information: Product Code 66739

Note: Not suitable as sole source of nutrition. Not for bottle or tube feeding.

Product Packaging 4 x 400 g

Calories Per Can 1888

Ingredients:

Per Suggested Per Suggested Corn Syrup Solids, Rice Starch, Refined Serving Serving Vegetable Oil (Non-Hydrogenated Nutrients Per 100 g (37 g Powder) Minerals Per 100 g (37 g Powder) Coconut, High Oleic Sunflower, Canola, Energy, kcal (kJ) 472 (1978) 175 (733) Calcium, mg 668 247 Sunflower), Sugar, Calcium Phosphate Tribasic, L-Arginine L-Aspartate, L-Leucine, Protein Equivalent, g 8.2 3.0 Phosphorus, mg 340 126 L-Lysine Acetate, Citric Acid Esters of Carbohydrate, g 67.4 24.9 Magnesium, mg 21.0 7.8 Mono- and Diglycerides, L-Glutamine, L-Proline, L-Valine, Glycine, L-Isoleucine, Fat, g 18.8 7.0 Iron, mg 5.9 2.2 L-Threonine, L-Phenylalanine, L-Tyrosine, Linoleic Acid, mg 3.2 1.2 Zinc, mg 4.1 1.5 L-Serine, L-Histidine, L-Alanine, L-Cystine, Vitamins L-Tryptophan, L-Methionine, Choline Manganese, mg 0.310 0.115 Bitartrate, Magnesium L-Aspartate, Vitamin A, IU 649 240 Copper, mg 0.310 0.115 Magnesium Acetate, M-Inositol, L-Ascorbic Vitamin D3, IU 172 63.6 Iodine, mg 0.414 0.0153 Acid, Ferrous Sulfate, Taurine, Zinc Sulfate, Vitamin E, IU 3.4 1.3 L-Carnitine, DL-Alpha Tocopheryl Acetate, Molybdenum, mg 0.0088 0.0033 Calcium D-Pantothenate, Niacinamide, Vitamin C, mg 23.0 8.5 Chromium, mg 0.0010 0.0004 Manganese Sulfate, Cupric Sulfate, Thiamine Thiamine, mg 0.250 0.093 Chloride Hydrochloride, Pyridoxine Selenium, mg 0.0113 0.0042 Riboflavin, mg 0.250 0.093 Hydrochloride, Riboflavin, Vitamin A Sodium, mg 38.0 14.1 Niacin, mg 1.1 0.40 Acetate, Potassium Iodide, Chromium Chloride, Folic Acid, Sodium Selenite, Vitamin B6, mg 0.250 0.093 Potassium, mg