Novel Health solutions for patients and consumers

Henk Joos, Managing Director FlandersBio

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Health Management Space Novel Health Solutions Challenges Smart Players adapt and collaborate Flanders Life Sciences Hot Spot… A safe harbour in the storm? Conclusions

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The perfect storm in health management space Unsustainable healthcare costs

The occurrence of mega-cities

Consumerism & digitization

Aging global population

Socio-economic & behavioral shifts

Global travel

New entrants moving into the health management space

Shift from curative to preventive

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Precision medicine, precision diagnostics

Social media

Data management systems

Health awareness and management

Key attributes of Novel Health Solutions Evidence based- and outcome- rather than technology-driven

Solicits consumer engagement and prevention

Driven from integrated dispersed data sources

Based on several integrated technology platforms

Stakeholder collaboration and co-creation essential

Individual consumers/patiënts are more and more at the centre Page 4

In the eye of the storm Mass ‘Market’

Insurers are starting to market directly to consumers

Nestle

Google Samsung

Danone

Unilever P&G

Apple Rousselot

Novel Health Solutions, A new mass market driven by growing risk factors Abbvie

J&J Medical device and diagnostic companies are also entering this space

Abbott ‘Niche Market’

Sanofi Aventis

Patiënts Page 5

Pfizer

Roche

Source: Winning the Battle for Consumer Healthcare, AT Kearney

Consumers at risk

Pleasure

Novel Health Solution examples

Innovative Delivery System for Senior Nutrition 08 December 2014 The Dutch start-up Fortified Food Coatings BV collaborated with Rousselot and DSM on a ready meal concept for the elderly, where nutrients [such as a blend of collagen peptides, vitamin D3 and calcium] are blended in a thin layer of gelatine that is sprayed over the meal and also stops the food from sliding on the plate, even when held at an angle. The concept is ideal for foodservice suppliers for the care homes for the elderly, with the fortified blend improving the presentation on the plate.

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From lifestock precision farming to health management

Deep Brain stimulation Rats

Patiënt

Movement analysis systems Condition management

Limping cows Page

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Challenges in new health management space

Differences in ‘typical’ product development timelines Differences/ Integration in regulatory systems Differences in business models Value driven vs cost driven Differences in financing models and sources Differences in language We have to train new people with new competence combinations Smart players adapt and collaborate !!! Page

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Business models change From Drug to Patient Outcome centric Screening test

Screening Test wellness programs

Wellness programs

Co Dx

Co Dx

Better Patient Outcomes

Rx Data / Algorithms

Data / Algorithms

Response Monitoring

Support the drug

Response Monitoring

Rx

Integrated solutions to improve outcomes

Biocartis and Janssen Collaboration History April 2010:

JJDC makes initial investment in Biocartis (Series B)

Jan 2011:

Janssen signs Collaboration and License Agreement with Biocartis for the Idylla platform in neurological disease and certain viral infectious diseases

2011 – 2013:

Idylla platform and assay development advances and JJDC continues to participate in funding

2014 – 2015:

Adapted the scope of our collaboration with more strategic focus on companion diagnostics

2015

Idylla Respiratory Viral Panel launch Idylla EVD = Rapid Ebola Triage Test launch Several other projects ongoing

The future of healthcare

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Biocartis’ Idylla™ Platform Precision Diagnostics Beyond Simplicity

Access on demand Ease of use – 2’ hands-on time – minimal training Contamination-controlled design High level of multiplexing (30+ markers) High Sensitivity Rapid results (35’ to 120’) Wide range of sample types Reliable – Reproducible results

EVOLUTION OF HEALTHCARE TECHNOLOGY EARLY 2000’s

1990’s •

10 ML BLOOD SAMPLE SIZE

•

CALCULATORSIZE GLUCOMETER

• GENOME SEQUENCING NOT POSSIBLE

• 3-10ML SAMPLE SIZE

2015

• 1/1,000 OF THE TYPICAL BLOOD SAMPLE

• BUSINESS CARD SIZE GLUCOMETER

• MINIMALLY-INVASIVE GLUCOMETER

• $1 M GENOME SEQUENCE

• $1000 GENOME SEQUENCE

MEET BLOOM A powerful yet simple wearable for women’s health

A life sciences driven network economy

254 organizations

57 126 71

with R&D activities with production activities dedicated competence providers

> 100 additional technology providers

>62.000 indirect jobs > 15.000 direct jobs

Companies are active in healthcare, agro and biobased applications

World Class Research centers

IMEC (1984) Nanotechnology • > 2000 employees • HQ: Leuven

International liasons with industry

VITO (1991) Environmental solutions

VIB (1996) Biotechnology

• > 700 researchers

• > 1300 researchers

• HQ: Geel

• Universities: Antwerp, VUB, UGent, KU Leuven

International liasons with industry

International liasons with pharma & biotech industry

iMinds (2004) ICT Solutions • > 850 researchers • Universities: Antwerp, VUB, UGent, KU Leuven, UHasselt • HQ: Ghent

#2 – INNOVATION ECOSYSTEM

Flanders: a Life Science driven network economy with strong (technology) partners

DSP Valley

IMinds

VIB

IMEC

Flanders Life Sciences Hot Spot Flanders Make

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VITO

Flanders: a Life Science driven network economy with strong technology partners The Flanders Life Sciences Hot Spot is in a unique position to ‘make’ the outcomes of the health management storm With players like: VIB, IMEC and Iminds… Biocartis, Multiplicom, Roche Diagnostics, ADX Neurosciences… Janssen Pharmaceutica, Ablynx, Galapagos, UCB… Materialize, Melotte, … We see it as an obligation and mandate to become one of the safe harbours in the global sea of health management Flanders and its decision makers are developing the ‘next stage’ long term vision to make this work.

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Novel Health Solutions for consumers and patients Key conclusions: Consumer/patiënt are in the center of the storm From treatment to health management Change and collaborate Health management players will converge Market becomes outcome driven from different technology platforms We need new compentence profiles The Flanders Life Sciences hot spot can be a save harbour YES, WE CAN IF WE DARE!

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FlandersBio: the engine of the life sciences cluster

FlandersBio: leads the life science driven network economy with 295 active members Key objectives: Knowledge valorization Talent pool Internationalisation Familiarisation Environment ‘In partnership for excellence’

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Thank you! I have been inspired by:

M3-BIORES

Thank you! FlandersBio vzw Jean Baptiste De Ghellincklaan 13 box 0102 9051 Ghent Belgium www.flandersbio.be www.knowledgeforgrowth.be [email protected]

Strategic partners FlandersBio