AD:-A262 901

92nd General Meeting 26-30 May 1992/ New Orleans, Louisiana

PROGRAM

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19930 SAPR DOT I 12

Grant No. DAMDl7-92-J-2015

Approved for public release; distribution unlimited

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OFFICERS OF THE SOCIETY President: RICHARD L. CROWELL, Microbiology and Immunology.

-lahneniann Uimrersit

School if Mcdl Iinc,

Broad & Vine Streets, Philadelphia, PA 19102-1192. Telephone: (215) 448-8273. President-Elect:JOHN INGRAHAM, Department of Microbiology. Uniersity of California. l)aN, CA 9.561 t phone: (916) 752-0273, Secretary: CYNTHIA A. NEEDHAM, Lahey Clinical Medical Center. 41 Mall Road. Burlingtom, MA 0180(5 phone: (617) 273-8936.

Teasurer: SAMUEL KAPLAN, Department of Microbiology. University of Texas Medical School. P () B(x 2(

cld-cf clC17).

Houston, TX 77225. Telephone: (713) 794-1742.

MEETINGS BOARD PAUL ACTOR, Chair, Paul Actor and Associates, Phoenixville, Pa. JOSEPHINE A. MORELLO, Chair. General Meeting Program Committee, University of Chicago Medical ('enter, Chicago, Ill. CLYDE THORNSBERRY, Chair, ICAAC, Institutes of Microbiology, Franklin. Tenn. RALPH A. SLEPECKY, Chair. Conferences Committee, Syracuse University. Syracuse, N.Y.

PROGRAM COMMITTEE JOSEPHINE A. MORELLO, Chair, University of Chicago Medical Center, Chicago. 111. JUDITH E. DOMER, Vice-Chair, Clinical Research Centre, Harrow. Middlesex, England STEPHEN LERNER, Divisional Group I Representative. Harper Hospital, Detroit, Mich. LUCIA ROTHMAN-DENES, Divisional Group II Representative. University of Chicago, Chicago, Ill. DANIEL Y.C. FUNG, Divisional Group III Representative. Kansas State University, Manhattan KATHRYN HOLMES, Divisional Group IV Representative. Uniformed Services University of the Health Sciences, Bethesda, Md. NANCY K. HALL, DivisionalGroup V Representative. University of Oklahoma College of Medicine, Oklahoma City

FUTURE MEETINGS General .eeting o/ the Societ-' 1993: Atlanta, Ga., 16-20 May. Abstract forms for tie submission of papers will be distributed with the August 1992 issue of the ASM News. 1994: Las Vegas. Nev.. 1-4 May. Interscience Conference on A4ntimicrobial Agents and Chemotherapy 1992: Anaheim, Calif, 11-14 October. 1993: New Orleans, La., 17-20 October. Upcoming ASM Conferences 30 August-4 September 1992. ASM Conference on Anaerobic Dehalogenation of Bacteria and Its Environmental Implicatiors. University of Georgia, Athens. 11-16 October 1992. ASM Conference on Genetics and Molecular Biology of Industrial Microorganisms. Bloomington. Ind. 15-19 November 1992. ASM Conference on the Biology of Halophilic Bacteria: Research Priorities for the 1990s. Williamsburg, Va. 25-28 March 1993. ASM Conference on Candida and Candidiasis, Baltimore. Md. April 1993. ASM Conference on Water Quality. San Juan, Puerto Rico.

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Proceedings

1992

F•UNDfN5

4. TITLE AND SUBTITLE

S.

American Society for Microbiology: Annual Meeting

DAMD17-92-J-2015

NUMBERS

6. AUTHOR(S)

Toby K.

Eisenstein 8. PERFORMiNG ORGANIZATION

7. PERFORMING ORGANIZATION NAME(S) AND AODRESS(ES)

Temple

REPORT NUMBER

University

Department of Microbiology 19140 Philadelphia, PA

9. SPONSORING

& Immunology

10, SPONSORING

MONITORING AGENCY NAME(S) AND ADDRESS(ES)

U.S. Army Medical Research & Development Fort Detrick 21702-5012 Frederick, Maryland

Command

MONITORWNG

AGENCY REPORT NUM8ER

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Program of the

92nd General Meeting of the

American Society for Microbiology Tuesday through Saturday, 26-30 May 1992

Accesion eor rNTIS CRA&i D TH C Z TABL

fly New Orleans, La.

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BioWhittaker, Inc. Brinkmann Instruments, Inc. Bristol-Myers Squibb Pharmaceutical Research Burroughs Wellcome (Company

Monsanto Company MSIlMicro Media S\ stni's Nalge (Conpany New Brunswick Scientdfic Company, Inc Norwich Eaton

Glaxo Inc. ICI Pharmaceuticals

Microbiologicals. Inc. Centocor, Inc.

Novo Nordisk Biotech. Inc. NuAire Inc.

Institutes for Microbiology

Connaught Laboratories

The NutraSweet Company

A

Abbott Laboratories Difco Laboratories Eli Lilly and Company

Institute

Carr-Scarborough

Limited

Research

Lab-Line Instruments, Inc. Miles Inc., Pharmaceutical Divisi n

Costar Corporation Chr. Hansen's Laboratorium

Ortho Pharmaceutical

Daiichi Pharmaceutical

Corporation Pfizer Labs Pfizer Pharmaceuticals, Roerig Medical Division Roche Laboratories G.D. Searle and Company SmithKline Beecham Pharmaceuticals The Symedco Group

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Amgen Inc.

BioMerieux Vitek (Systems), Inc.

Genentech, Inc.

Pharmaceuticals, Inc.

Organon Teknika

Ortho Diagnostic Systems, Inc. Pacific Biotech, Inc.

Denmark A/S Chrisope Technologies, Inc.

Panlabs, Inc. Pfizer Inc., Central Research

Corporation Dainippon Pharmaceutical Co. Ltd. Deltown Specialties Denley Instruments, Inc. Du Pont Medical Products Diagnostics & Biotechnology Systems Eastman Kodak Company EM Diagnostic Systems Forma Scientific, Inc. Fotodyne Incorporated FTS Systems, Inc. Fujisawa Pharmaceutical

Pharmacia LKB Biotechnolohg. Inc. Pitman-Moore, Inc. Pro-Lab Diagnostics Radiometer America Inc. Sensititre Systems Group Rainin Instrument Company. Inc. Remel Revco Scientific, Inc. Ribi ImmunoChem Research. Inc. Rupp & Bowman Company Sandoz Pharma Ltd.

Co., Ltd.

GEN-PROBE Incorporated

Hoechst-Roussel

Pharmaceuticals Inc.

Division

Sanofi Diagnostics Pasteur Savyon Diagnostics Ltd-

Schering Corporation

Schleicher & Schuell. Inc.

Janssen Pharmaceutica Marion Merrell Dow, Inc.

ImClone Systems Inc. Ingold Electrodes, Inc.

Sheffield Products Division, Quest International

Ortho Biotech

Innovative Diagnostic

Sigma Cell Culture Reagents

Rhone-Poulenc Rorer

AB Biodisk Adams Scientific, Inc. Alexon, Inc. Amsco Scientific Anaerobe Systems Applied Biosystems, Inc. The Baker Company, Inc. Banyu Pharmaceutical Company, Ltd. Baxter Diagnostics Inc., MicroScan Division Becton Dickinson & Company Bellco Glass, Inc. Biolog, Inc.

Systems, Inc.

Integrated Diagnostics, Inc. Johnson & Johnson Corporate Kirkegaard & Perry Laboratories, Inc. Leica, Inc. 3M Medical-Surgical Division Infection Control Products Mead .Johnson Nutritional Group Medical Technology Corporation Medical Wire and Equipment Company Meridian I)iagnostics, Inc. Microbiology Reference Laboratory (MRL) Mitlipore Corporation

SmithKline Diagnostics, Inc. Specialty Laboratories, Inc. Sulzer Biotech Systems Syva Company T Cell Diagnostics, Inc. Traders Protein Unipath Co. Oxoid Division The Upjohn Company USDA, APHIS, Biotechnology, Biologics, and Environmental Protection Vangard International Inc. The VirTis Company, Inc. Wampole Laboratories The William Byrd Press, Inc Williams & Wilkins -t ,,,:

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CONTENTS Officers of the Society ............................................ ................

.............. ......... . .Inside Fro n C(-)%er ..... .....Inside Front Cover Meetings Board ....................... .......................................... .....-.... ............. Insid Fron Coe Program Committee ...................- .... ...... ....................................... .............. Inside Front Cuver Future Meetings......................................... ........ .......................... ' .......................................... Invitation ..... ..... ...... ....................................... ............... .........................................................--........... General Information........... ..................... ...... ........................................... Hotel Reservations.................. Discounted Air Travel .................................................................................... ... .............................................................. Discount Car Rental ........................-..... Parking Facilities at the New Orleans Convention Center....................................v ....... ...... Bus Service .........................................................-.............................................. ............. . ..'.. .............................. Advance Registration................................................... ... ... 4. ............................................--...........................--...... Registration ................. ..... ...... ...............--....................... ................ ........... Location of Scientific Sessions............... ......-% ................ ASM Program and Services .......... .............................-................................ ................ ... ' 1i ASM Telephone Housing Form ...............................--.........--............................... -.............--....-........... ........---- vwl Map of New Orleans.................-............................................. 1992 General Meeting Hotels ................................................. ........................ ....--.................- ix .............. xni Information Center................................................................................................ xiii Mail and Messages ....................................................................................-....-........-........ ..... ..-- X111 ----..... ..... .... ................. Media Facilities............................................................... ....................-............... xiui .................................................. Business Service Center .................. ................................. xiii International Lounge......................................................... .............. . ......- xliii Placement Service.................................................. ..................................................... . ...................... xiv ........ ......... Previewing Slides...................................................................... .............. i .................. . ............................ Food Service ..................................................... .....-................. ...... xiv Coat and Bag Check Service ............ ....................................................... ........... --....... xiv First Aid...................................................................... ............................. Xiv ........................... Badge Recycling............................................................. ...................... . --.......... xiv Important Telephone Numbers.......................................................... ...................... ... xiv Smoking ................................................................. ......................................................... ......... ....... ........ vii Activities ................................................................................................ .......................... ................ .... xiv Opening Session .................................................................. ................................................ ........ ............ xiv Opening Reception...................................... ......... xiv Presidential Address............................ ....................................................................... Xiv Eli Lilly Award Address.................................................................. ..................................... xiv President's Forum (Sponsored by the New Brunswick Scientific Company)............................................ ...................xv President's Reception ................................................-....................................... ....... xv ........... ..-......................--.................. and Lecture .......... Porter Award Presentation J. Roger ... xv . ......................................... Sonnenwir-th Memorial Lecture.................................................. -.......... -X Becton Dickinson Award/Division C Lecture............-....................................................... xv Cetus Corporation Biotechnology Research Award ......................................................................... xv Carski Foundation Distinguished Teaching Award ......................................................................... ... Xvi Scherago-Rubin Award..................................................................................................... --..... xvi Raymond W. Sarber Fellowship Awards ..................................................................-.......... ....... xvi Vector Laboratories Young Investigator Travel Awards ..............-................-........................... ...... ..- xvi Luncheon for Presidents and Secretaries of Local Branches .................................................. ...... --........... xvi New Member Orientation......................................................................... ......... xvi Branch Officers Forum ............................................ ........ -......................................... ......... xvi Division Officers Forum ....... ..................... ................................................................ xvii . ............. .................. . ........... General Membership Meeting of ASM... .................................... . --.............. Xvii Local Committee on Arrangements ..................................................................... Tours .......................................................................... ....... ................... ........... ........... xvii .... xvii ...... .......... .......... Golf and Tennis Day ..................-......................................... ,

iii

G uest Hospitality C enter ................................ ........................................... .XV1 C hild C are C enter ............................................................................................................ xvii E x h ib its ........................ ............... ................................ ..... .......................... ... .. ............ ............................... . .... xvii Technical Exhibits .......................................................................... ............. .xvii Scientific Exhibits ................... ............ ..... ..... . .......... .. XX A m erican A cadem y O f M icrobioiogy Program s ........................................................................................................ XX Documentation of Meeting Attendance for Category I Continuing Medical Education ........................... xx W orkshops .............. ................................................................. ........................ xx General Information ........................... ............................................. ............ xx R eg istratio n ............................................ . ................ ........................... ...................... ......... ...... ............ . .... Xxi W orkshop O rientation P rogram .................................................. ............................ . ......................................... xxi Teaching M aterials Presentations ................ . ........................ ....... .. ........................................ ........ xxi A udiotaping of Selected W orkshops and Sessions ................................................................................................... xxi Educational Products and Services ........................................................... xxii Divisional Business Meetings ...................... ...................................................... xxii Professional and Educational Sessions ........................................................................................................... xxiii 1992 G eneral M eeting W orkshops ...................................................................................................... ........................ xxv Personal D ata Form , Placem ent Service .................................................................... ........................................ xxxi 1992 G eneral M eeting Session Titles ................................................. ....................................................................... xxxiii Scientific Ses .ons ................................................................. . . . ..... ......................... . . . ......................................... .......... W ed nesd ay (Sessions 2-83) ......................................................................................................... ........................... Th ursday (Sessions 84-168) ........................................ ................................................................................... . .......... 39 Friday (Sessions 169-252A) ................ ................................................... 79 S atu rd ay (S essio n s 253-3 16) ................................................................ ....................................................................... 118 P articip an t In dex ............................................................................................................................ ................... ....... 15 3 Sum m ary of Scientific Sessions ................................................................................................ ........................... ......... 170 Floor Plans of New Orleans Convention Center .............................................................................. .. Inside back cover 1992 G eneral M eeting O fficial A ppointm ents ................................................................................................. Back cover

iv

The 92nd General Meeting of the

American Society for Microbiology New Orleans, La. 26-30 May 1992 Delta Airlines is offering the following spe-

INVITATION INVITATIO hodit2deealMe ASM will hold its 92nd General Meeting in New Orleans, La. ASM '92 is scheduled from 26 to 30 May 1992. You can enjoy the many fun activities that New Orleans

cial discount air fares to New Orleans for those attending the General Meeting: '40% off full coach fares on Delta's domestic system 435% off full coach fares from Canada

has to offer while you learn of the latest advances in your field of scientific interest. Hotel rooms are in abundance, and all have easy access to the New Orleans Convention Center, tle venue for this year's meeting, via ASM's continuous shuttle service. The General Meeting Program Committee has once again organized a comprehensive scientific program consisting of symposia, seminars, round tables, and slide and poster sessions, all planned with an eye to giving you the most up-to-date information possible. Technical and scientific exhibitors will display their latest products and services during the meeting.

°5% off promotional fares To take advantage of these Delta discounts, call 1-800241-6760 and refer to file number HO112. Reservations can be booked through Delta's Meeting Network seven days a week, from 8:00 A.M. to 8:00 P.M. (Eastern time). Airlin V

American Airlines is pleased to offer discount airfare to ASM's 92nd General Meeting. Choose from the following disco nts: 150% off full coach fares from the 48 contiguous utats, Hawaii, Puerto Rico, and the Virgin Islands.

AM

°40% off full coach fare from Canada 05% off lowest promotional fare (rules and restrictions

GENERAL INFORMATION

apply) To receive one of the above discounts you must make your reservations through the American Airlines Meeting Desk (1-800-433-1790) and mention ASM's STAR file number S12Z2G5. You may book your reservations through the American Airlines Meeting Desk seven days a week, from 7 A.M. to 12 midnight (Central time).

Hotel Reservations Hotel rooms will be available for all interested individuals who use the Telephone Housing Form (p. vii) and respond by the published deadline to the phone number noted. Only reservations placed through the housing bureau will receivc conventivai ratcs. Hotels will send confirmations for all reservations received by 20 April 1992. Reservations must be placed with the ASM Housing Bureau only. Rooms will be assigned at the convention rates on a space-available basis. All hotels require a deposit for the first night's occupancy by a date that will be noted on the reservation confirmation. If the deposit is not received by the hotel, the reservation will be cancelled. If a reservation cannot be used, please make it available for reassignment by prompt cancellation. If any other changes must be made, please make them directly with the hotel after receipt of the reservation confirmation. Deposits are nonrefundable if cancellation is not received within 72 hours of your scheduled arrival,

Discounted Car Rental Alamo Rent a Car has been appointed the official car rental cornpany for the 92nd General Meeting Where all the miles of the American Society for Microbiare free ology, 26-30 May 1992, in New Orleans, La. Special discounted rates have been extended one week prior to and one week following the meeting. UNLIMITED FREE MILEAGE. Be sure to inquire about SPECIAL LOW ASM RATES that provide even greater savings for rentals over the Memorial Day weekend only. Come early and take a drive through the swamp country or visit the plantations along River Road before the ASM meeting. To make reservations call Alamo at 1-800-732-3232 and request Group I.D. #247853 and Rate Code G I if you want to take advantage of the Memorial Day weekend special. Rate Code G3 is for all other times and rates.

Discounted Air Travel Delta Airlines and American Airlines are the official co-carriers for ASM's 92nd General Meeting. v

Parking Facilities at the New Orleans Convention Center The New Orleans Convention Center has three surface lots and two garage levels for a total of 1,908 parking spaces. Fees are $4 per day in the garage or $3 per day for outdoor parking. An unlimited access pass for the duration of the meeting will be available for $33 and may be purchased at the exhibitor service center. Refer to the ASM Housing Form for parking fees at official ASM hotels.

Monday, 25 May (Exhibitors only) ...................... Tuesday, 26 May................ Wednesday, 27 May .................. ............ Thursday, 28 May ...... Friday, 29 May......... .

8:00 8:00 7:{00 8:00 8:00

Saturday, 30 May ............

8:00 A.M.-2:00 P.m.

A.Mi.-5:00 P.M A.M.--8:00 P.M. A.M.-5:X) P.M. A 51 -5 00 P.M. A.M.-5:00 Pm.

Only members who have paid 1992 ASM dues can register at member rates. Members who register at the time of the meeting must present a 1992 Membership Card or have their status verified at the Membership Desk. Students must also certify their student status by presenting a 1992 Student Membership Card or other certification of student status at the Membership Desk. Preregistration and on-site registration fees are listed below and on the registration form. Those who preregister are entitled to a discount.

Bus Service Shuttle buses will provide frequent service between the participating hotels and the New Orleans Convention Center during the days of the General Meeting. Continuous shuttle service will be provided during the day. Buses will also operate during Tuesday registration hours and for the Opening Session at the Convention Center and Opening Reception at the New Orleans Aquarium of the Americas. To accommodate those attending the Wednesday, Thursday, and Friday late afternoon scientific sessions, the last buses will depart from the Convention Center 15 minutes after the close of the last sessions. Shuttle service is provided only to registrants who have reserved hotel rooms via the ASM Housing Bureau. Exact bus schedules will be posted in the lobbies of all ASM hotels and the New Orleans Convention Center. Bus service is available for those who are disabled. Please contact ASM Headquarters for further information.

Before 20 April $ 85 ...................... Member* $135 Nonmember* .................................. $ 35 Emeritus or honorary member* .... $ 35 Student (member)* ............... $ 50 Student (nonmember)*............ Spouse (nonscientist) ................ $ 20 $25 Abstracts of 1992 General Mtg $ 10 CME Credit Form ......................... *Includes a copy of the Program.

After 20 April $105 $155 $ 45 $ 45 $ 60 $ 20 $25 $ 10

Personal checks and credit cards will be accepted only for the exact amount of registration fees. Admission to sessions and exhibits will be restricted to those displaying the official registration badge.

Advance Registration Preregistrants will receive confirmation by mail. Badges will be mailed beginning 20 April 1992. Note that credit card registration is available for advance as well as on-site registration. U.S. members and nonmembers who preregister and pay $25 will receive the Abstracts of the GeneralMeeting of the American Society for Microbiology (if ordered) by mail. Abstracts ordered by international preregistrants will be available for pickup at the Preregistered counter in the New Orleans Convention Center; please present your meeting registration confirmation in order to obtain your abstracts. Additional registration forms are available from the ASM Meetings Department, 1325 Massachusetts Avenue, N.W., Washington, DC 20005 [ASM Meetings Hotline (202) 737-03771.

Location of Scientific Sessions All of the scientific sessions will be located in the New Orleans Convention Center. For exact session locations, consult the session listings in the Program and the floor plans inside the back cover of the Program. A section of Exhibit Hall C has been set aside for poster sessions.

ASM Programs and Services In the lobby of the New Orleans Convention Center, ASM headquarters staff will operate booths where meeting attendees may find information about ASM membership, education and professional recognition programs. and the American Academy of Microbiology. The latest ASM publications will be available for purchase as well. All ASM booths will be open during published registration hours.

Registration Registration and associated activities will be in the New Orleans Convention Center. Registration hours will be as follows: vi

TELEPHONE HOUSING FORM--DO NOT MAIL 92nd General Meeting, New Orleans, La 26-30 May 1992 1-800 HOUSING INSTRUCTIONS DEADLINE: U.S. attendees, 20 April 1992; non-U.S. attendees, 13 April 1992 Prior to calling the Housing Bureau for reservations please read all housing information carefully and complete the form below. It may take 3 to 4 minutes to complete your call, but less if you have all of the following information ready when you place your reservation. The Housing Bureau is open Monday to Friday from 7:00 a.m. to 7:00 p.m. (central standard time). All hotels require a deposit equal to one night's room rate (including tax). Deposits can be madL. by credit card or check. If you are making your deposit by check, send the deposit directly to the hotel upon receipt of the hotel's acknowledgment. For groups of 25 or more, first and last night's room deposits will be required.

United States (including Alaska and Hawaii)

(800) 345-1187

Metropolitan New Orleans Aa ...........

..........

(504) 566-5005

Fax (non-US. registrants only) .............. ....

( 504) 522-6123

Accommodation Requested: Hotel Choices: 1st Choice __ 2nd Choice __ 3rd Choice __ El Room must be suitable for handicapped

Single (1 person, 1 bed) Double (2 persons, 1 bed) Twin (2 persons, 2 beds) El Suite

Please note those sharing a room. Name

Arrival Date/Hour

Departure Date

SEND CONFIRMATION TO: For reservation deposits via a major credit card, provide the following information:

Name Company

Type of credit card

Address

Credit card number

City, state, ZIP code

Expiration date

Telephone no.

____________

Fax no. An acknowledgment will be sent to you by the Housing Bureau, and confirmation will be sent to you by your assigned hotel. Please read your confirmation immediately and carefully for inst-uctions regarding deposit requirements and check-in. ALL CHANGES OR CANCELLATIONS SHOULD BE MADE DIRECTLY WITH THE HOUSING BUREAU ((504) 566-5005)]. CANCELLATIONS MADE LESS THAN 72 HOURS BEFORE ARRIVAL SHOULD BE MADE DIRECTLY WITH THE HOTEL TO ENSURE PROPER CREDIT. Note: To take advantage of ASM services and amenities such as ASM Shuttle Bus Service, Daily ASM Conference Journal, and Direct Line Service, registrants must use the ASM Housing Bureau and stay at an official ASM hotel.

vii

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NO SMOKING IN SESSIONS OR IN POSTER AREA

*

I

CENCI, arid F, BIST( NL1. Dept. of Ex.p. Med., Unii. of Perugia, Perugia. Italy. B340.~~~~ Teprait'trj~o Mice for Endoroxii,.l r(LiCed Disseminated Intraisascular Coagulation Yields Similar ReSuits by Fail Clip or Cardiac Puncture Methos.. dBlood Collection. 1'180) D GREGG." J. BUKOVICH. arid E, CARLSON. Michigan fechnological Uoiis i~oughton,

Session 287 (B). HOST FACTORS IN INFECTION: SPECIFIC AND NONSPECIFIC

DEFENSES

8341.

Host Cell Ak.tin Pros ides thre Propulsive Force for the

Intracellular Miosement of Listeria mlonocvtogeni's. (182) F. S. SOU THWICK,* J_ M. SANGER, and J_ W. SANGER. Univ,

of Florida, Gaine~si-ile. atid Univ, of Pennsslsaia.a Philadelphia. B342. Interaction of Opaque anid Transl ucent Variants of' Vibrio vulnificus with Peritoneal Exudate Cells. (184) L M. SIMPSON.* J, C. TRAVIS. and J. D_ OLIVER, Univ. of North Carolina. Charlotte. 83343. Depiction of CD4 -and/or CD8 T Cells. Promnoteýs Bacterial Translocation from the Intestines. (186) Mi. GAU'rREAUX* and R. BERG. Louisiana State Univ. Med. Ctr.. Shreiieport. 83344. Cytokine Expression of HEp-2 Cells. U-937 Cells, and Neutrophils in Cellular Coincubation Experiments with Intracellular Bacteria (Listeria spp.. Yeriinia spp.). (188) R, ARNOLD, j. SCHEFFER, anid W. KONIG.' Med. M~ikrobiologic und Immunologic. AG Infektabwehr, Ruhr Univ. Bochum. Bochum, Germany. B345. Mligra tion of Poly morphonuclear Leukocytes to Pseudomonas aezýuginosa Chemotactins: Priming by Interleukin-1I3 and Inhibition by Piroxicam. (190) P. A. FONTAN, C. R. AMURA, and D. 0. SORDELLI.' Univ. of Buenos Aires, Buenos Aires, Argentina. 8346. Type I Fimbriae Protect Escheric/iia coi from Bactericida' A,.tivity of Human Poly morphon uclear Leukocytes. (192) J. MACGREGOR,* T. IKEDA, R. J. LITTLE, R_ TEWARI, L. HIMPEL. and S. N. ABRAHAM. Washington Univ. Sch. of Mied.. St. Louis, Mo. B347. Arachidonic Metabolites in Acute Pyelonephritis. (194) J. A. ROBERTS,' B. KAACK, and D. B. MCNAMARA. Tulane Regional Primate Res. Ctr.. Covington, L~a. 1130. iflaemophiius influenizae b Meningitis-. Advantage of Treatments with Amikacin To Reduce the Lipooligosaccharide Biological Activities. (196) V. GOIJRY, H. BENNANI, A. TIBI, 0. BAILLON. E. BINGEN. and J. C. DARBORD.' Robert Debre Hosp. and Paris V Univ., Paris, France. B349. %'-Acetylmuramyl-t.-AlanVI~-D-sogiLutamine Potentiates, Production of Interleukin-lI in P388D1I Macrophages. (198) D. MORGENSTERN.* B. S. K WON, and R. S. ROSENTHAL. Indiana Univ. Sch. Of Med., Indianapolis. 13350. Activation of Alveolar Macrophages for Anti-Francisella Effector Functions5 . (200) T. POLSINELLI.I. A. H. FORTIER. and C. A. NACY. Walter Reed Army Inst. of Res.. Washington, D.C. B351. Effect of Short-Chain Fatty Acids on Procoagulant Production by Leukocytes. (202) G. MIRAGLIOTTA,' G. BOTTA, A. ARZfLSF, A. MOSCA, and R. DEL PRETE, Inst of Microbiol.. Univ. of Bari. Bari, Italy. and Univ. of

Udine, Udine. Italy. B352. Inhibition of Blood Clearance of Klebhsiellapneumoniae in Mice !hy Capsular Polysaccharidesi Specific for a Macrophage L~eetin. (204) A ATHAMNA. N. SHARON, (i. G, S. DUI~t~ON., and 1I OFEK." Tel Avis Univ., T el Aviv. Israel, #

GENERAL MEETING

'A Ciinianri Inst oif Sci, Rebus 'tkal and Lruiii od 1r 0 sh Col uiobia. Van:ou-,r ~intriish (.Xu nbii (.adai 11353. C,, totokicity of Lci~io'ncll pnuo.un'philu for Mono u, lvAr Phagoc'. tes 1206) 1. HUSMAN N arid W "' )ONS)N l L'ni' of low a, Iowa Cib B354. Increcased Fiidotoxiii Lcthalt\ and tDccrcasicd Serum Tumor Nc~.rosi', Factor Alpha Ics els In Mick: h%l'ertusi.s loxiti. ý208j F. VOGEL, .'I GIAMPAGLIIA, anid J S() [I1Lecderle-Pra'.i' tBioltigi~als. Pearl Riser. NA' 8355. Gamma Interferon I eiels in Serum~ arid Bronchoals coldf Lavage Fluid of Mice tnficcied with BorticIiell prraiuso. (210i D) TORRE.* A PLGL.IE S, R [AMIIBIN1. 1. PLRVLRSI. P- MARONE. arid F. SPERANZA D~i%.tt Infectious Diseases, Varese, ltaly ' !.ist. of' Infectious lDiscascs, I urin, Itali.

and Inst. of Infectious Diseases., Pasta. Ital%. B356. Propionibactrirutn acnci, Primting of Mice fur Ltpo''ihgosaccharide IHypersensitisity Is Rc'.er'.cd bs Moriophospht r,, I

Lipid A Treatmient. (212) J. R WARD).* Y Mi HUDSON, anid J. T_ ULRICHI. Ribi litrnutiochern R,--,. bfc , flarmion. Mont, 13357. Risk of Lethal Infection with Escherichiu cobe K I in Autoimmune Mlice Correlates with Defects in PoI~morphionuClear Leukoevte Fu~nction. (214) J. LOWRANCE,* H4 GRVSHAM, and F. O'SULI.IVAN VA Med C'tr and I'm'.(iof ,Missouri, Columbia. 8358. Molecular Characterization oft cO)NA'. i-tiodiiig lout Rat Neutrophil Defensins. (216) N. Y. YOUNT* and M F SELSTED. Dept. oif Pathology, Col. of Med.. Unis of California, Irvine. 8359. Purification and Characterization of 1 wo Murine Intestinal Defensins. Cryptdin I and Crypidin 2 (2I18) P, 13 EISENHAUER,* S S. L. HARWIG. anid R 1. LEHRER UICLA. Los Angeles, Calif. B360. Bacteriostatic Activity (if Bile Salts in Relation ito Hydrophobicity of the Molecule and Micelle Formation with Phospholipid. (220) J. Y. SUNG,' K LAM, Mi. RESEK. and E. A. SHAFFER. Unis. of CalgarN. Calgary. Alberta. Canada. and Chinese Unis. of Hong Kong, Hong Kong. 13361. Acute Pancreatitis Enhances the Lethal Efftect of Endotoxin. (222) M. REILLY,* 1), MEDICH, anid W' SCHRAUT. Univ. of Pittsburgh, Pittsburgh, Pa. 8362. Effect of Chronic Fasting on Recrudescence of an Intestinal Infection by. Salmonella en:'rindid, in Chickens (224) P. HOLT* and R. PORTER. JR. USDA. Agricultural Res.. Serv ice, Southeast Poultry Re'. Lab.. Athens. Ga. 13363. Fasting Increases the Seierity .)f Intestinal Lesions Caused by Salmonella enterdidis in Adult Chickens, '215i R. PORTER. JR..' and P. HOLT. USDA, Agricultural Res. Service, Southeast Poultry Res. Lab.. Athenis. Ga. B364. Peptidoglycan Fragments. Suppress Appetite In Rats, (228,) K. J. BIBERSTINE* and R. S ROSENTHAL, Indiana Univ. Sch. of Med., Indianapolis. 8365. Effect of Weight. Acclimation Time, and Strain of %lice oin Their Susceptibility to Respiratory Infectionwimth Paiwcrc1la multocida. (230,) F. H WEBlER, Central Res. Dii-. Pfiier. Inc., Terre Haute, Ind. 13366. Seleuive Decontamination of the Dirgesiive I tact and Colonization Resistance iii Mice (232) A. S. AMEEN.' A B J, SPEEKENBRINK. and S. R. Al COCK tnt'. lDept of Bacteriol.. Western Infirmary. Gsgi.United Kingdom) 8367. Calprotectini a Nokse 1 Anticandidal Host D~efense f(234ý A. R. MURTHY.' K. T' MI'iASAKI. and R I I.EIIRFR VA Med. Ctr., Sepulveda. Calif.. anid UCL.A. IL(is Aiigelcs, Calif. 13368. Heic~ibhuctrpc/or L~ipopol 'vsac-haride fiom s t iui atic anid Duode-ial Ulcer Patients -sokes IDiftcreni Dcgrees oti Stimulation iif Pepsiniigen Relt'asct 236) ' A. I A.S I()VI( N.-.. G. 0) Y( UnN(. N SIVA MMII. J A. IJ()l %V mid I N

1993. ATLANTA, GA., 16.20 MAY

*

NI ARKS. Dept. of Nicrobiol., Red Crovs FHosp adG, to testinal Chiu., Dept of Med .U itix of Cape Townr and (ironic Shuu~r Hosp.. Cape Tow~n, South Africa. B369. Progressiset TiNsLue Necrosis and the Effectsý of Aloe, 123,S

Session 290 (0) GENE TRANSFER IN THE ENVIRONMENT

). P. HILIL, J. STAHJEI1 J. P_ UIE(AERS.* R. P. ELLEY NAUL and W. WIN'TERS. Shriners Hurns Int. and Univ, of' Texas Med. Branch, Gal\S1011t an d I'mni. ofTIe.xa, HeIalth Sc Ctr., San Antonio. B370. Cs rokine Production in [Experimneital (Group B Streptoc(G. MANCU~SO, and F Cal Infection,, 240) G. I I- II TONIASELL[0. Istituto dit Nlirohiol . aeolta it %led., Uni" di Niessina, Mvessina, Itali,

Saturday, 1:30

i'.m.,

Room 12

NilLi FR, )lahtiontta State Luniv 'dtrur.RIEIV AE A (,II AI I, IDrec l Uni'. PhidaSt ills'.ater, andi NIICHII deiphim. Pa, 1:30

Session 288 (BET, R). Seminar (Eigbt, ghorxtiun

dcu

Cricdo)

UPDATE '92 111

Q329. I %Idence for Gene I lanuski arnotiv P idornloplua Medial ed throuitgh Phagvs on Plant leaf Surta cc, S P K 1DA NIBLO S. RIPP. and R, V '0 11.14:1K( Oklahomna State Uniis

Stillwsater.

Q330. Natural I'Lostnd

I-ratisloTRIJatmon in a Hfigh- Erequenexy-

of-iFransforniatio n Marine Vibno Variable, Affecting Competerici. M. E FRISCHLR,* J MI I HIRMONI). and J 11 1) X L L i cDpt of Marine See , Uniu oft South Floirida, St

Saturday-, _'oon, Room 13 Cotnvenors: PAUL TABOR. Clarke Col_. Dubuque. Iowa, and JOHN MI LAMM`vERTF. GustasuLs Adolphus Col.. St. Peter, Minnii.

Petersburg.

Q331.

Horizontal (Gine Iransfer iii Aquatic Microcosmn W - L CHfAO,* B.-W. WANG. anid H.-C WOJNGi. D)ept. of MicroNiot , Soochox' Unri .. I aipei, 'I aim.an, Repuhlic of China

Q332. Up~date '42 in) Microbial Disersits D)AVID A STAHlL. Univ. of Illinois. Urbana

Drug Resistance Transfer of the: Bacteria Associated w'ith Marine Aquacuitural Animals. C. It HISU Nat Sun Yat-sen UniN KaOhskiung. Taiwan, Republic of China.

2:30

Q333. K 89 H).Semnarmation (, Sesson

H).uioSremit) Session289 (Q, Kiipug fkilgibc

[ he Effect of Div alera Can ons on Itthe Binding of DNA to Marine Sediments and On the F-rcqucnc% of Natural TransforD In P~ewdorownu( .tuu:ri Zoliell. K. GA RK(.).

WINGFIELD, ;ind (1. STLAWART Dept of Hiol.. Unix of'

eucaioncreit)South fr cniiuins'

MICROBIAL METAL-BINDING PEPTIDES: GENE REGULATION AND FUNCTION

Florida. Tamnpa.

Q334. Effect of F-erric Ion on Expression of the trai (Gene of the Ctonjulgatise Plasinid RlOO)-l S SELVARAJNAM,* I KHALIL, and MI A. GEALT. IDept. (if Hiosci and Biotech-

nology. Drex'ei Urn%.. Phluadelphia. Pa.

Q335. Gene Transfer from Geneticall\ F'ingieered Nficroiorganisms to Aquatic Microbial Comnnmuntes Detected hx Assemblv of a Catabolic I'aihway "r BARKAY, MI. GILLMIAN, anid C. LIEHERI. U.S EPA anid rechnologv Resources Inc_

Saturday, 1:30 P'.m.. Room 10 Contveneror: MICHAEL RHODES and SIMON SILVER. Lois> Ifllinois, Col. of M-ed., Chicago Succharornycs cerevisia MetalHot hiotici n: Regulation and Synthesis D)EAN H, HAMER. NIH. Bethesda. Md. Cyanohbacierial S~vncchovoccus Metal lot hionein: Molecular 131obNIG EL J. ROBINSON. Univ. of 1)urhamn. D~urham, U. K. Cvanohacterial and O.ther Prokarvotic Metallothioneins SUSAN RHODES, Univ. oif Illintois. Chicago

Sabine Island. Gultffireezc, Fla. Aco Stirmial (i [reezcUDried (,enelicall. Enierd organisms in Air and the Eftect of V'isible Light E ISRAELI,* 1. T.- SHAFFER. J. A HIOYT. H.LIHTH ART. andi 1. M_ GAN 10 U.S. EPA aiid Mvan-Fech Enik ironmenial. Enxi rorimental Res. Iah . Cortallis, Orcg

Q336.

3:30 Q337.

Stir,, i,,al, Gjene 'I ransfer. anid I caching of a (jencticalls Engineered Pwuzdotnoptaý aerugmotu in an Undisturbed Soil Column. K. W. L..{VINS.' I S. ANGIE'. J, REDSON, and R L, HitLL. Univ. of Mvarvland, Collece Park Q338. (jene -1ransf-er in Soil. Indigenoný Reetpients oft Plasmird

R6_45ý J. 6. GLFW, J. S. ANGLE," and MI. J SADOWScio'a--hr~ncxpoinhe Phytochelatins.- Polyglutathioncelike metal !fo'gPetc I)ENNIS R WINGI-> Univ. of Utah Med. Cir.. Salt Lake City Phytocheclatin S~ nthcsis, aridl Metal I olerance in Plants PIl IX VR 11( )LI.)SIROU( ill. Purdue Crnis , W Lafayette. Inrd

SKY. U nix. of Marlyland. College Park. and Unit oif Minnexoa. St, Paul. Q339. I ransfcr oif the IncP Plasmiids ph' 4 aiid risý.45' between Hrads rfii/ohia Populat ions, in Natural Soil H K K IN K L., F. L, SCHMIDT. M,. J, SADiO WSKY. aind 'A' C. KOSK INFN. USDA. Agricultural Ri-s Sers we, aind Soil S, i Dept tUniv of Mitinvsota, St P'aul

* NO SMOKING IN SESSIONS OR IN POSTER AREA

*

Session 291 (H). Seminar

Session 293 (K)

(Eligible ]br continuing educatin credit)

EXTRACELLULAR DESTINY OF GRAMNEGATIVE POLYPEPTIDES Saturday, 1:30 P~.

REGULATION OF BIOSYNTHETIC PATHWAYS

Room 43

Convenors: YANKEL MI. KUPERSZTOCH. Univ. of Texas Southwestern Med. Ctr., Dallas, and RODNEY WELCH, Univ. of Wisconsin, Madison ExtaclluarEntrooxns:SeretrvPatwa o th Hat-tale :SceoyPhwyfteHe-Sal ErceuarEnterotoxins YANKEL M. KUPERSZTOCH, Univ, of Texas Southwesterni Med. Ctr.. Dallas Secretion of Hemolysins RODNEY A. WELCH, Univ, of Wisconsin, Madison Export of Killer Peptidles ROBERTO KOLTER. Harvard Med. Sch., Boston, Mass, Mechanism of Secretion of Immunoglobulin A Protease ANDREW WRIGHT, Tufts Med. Sch.. Boston, Mass. Passing through the Periplasm? Protein Secretion by Vibrio sp. THOMAS BUCKLEY, Univ. of Victoria, Victoria, British Columbia, Canada

Session 292 (1). Seminar (Eliibl (Eliibl

coninung foducaioncreit)Tetrapyrrole forconiniing ductioncreit)Microbiol..

CAIRNSIAN MUTATIONS: A SPECIFIC RESPONSE TO STRESS? Saturday, 1:30 P.mz., Room 39 Con venors., ANNE MORRIS HOOKE, Miami Univ., Oxford, Ohio. and MICHAEL MALAVASIC. Georgetown Univ. Med. Sch., Washington. D.C. Directed Mutations: Facts and Theories PATRICIA L. FOSTER, Boston Univ. Sch. of PubI. Health, Boston, Mass. Estimating the Degree to Which Selection -Induced Mutations Are Specific to the Environmental Challenge Applied BARRY HALL, Univ. of Rochester, Rochester, N.Y. Cairnsian Mutations in Yeast: Mechanisms? SUE 3 INKS-ROBERTSON, Emory Univ., Atlanta, Ga "Pseudorevertants" of Temperature-Sensitive Salmonella typhi MICHAEL MALAVASIC, Georgetown Univ. Med. Sch., Washington, D.C. Evaluation of Directed Mutation end Alternative Hypotheses JOHN MITTLER and RICHARD LENSKI, Univ. of California, Irvine Summary: Overview arid Views FRANKLIN W. STAHL. Univ. of Oregon, Eugene

*

Saturday, 1:30 P'.m., Room 41

Moderators. R. MEGANATHAN, Northern Mlinot, DeKalb, and ALAN J BIEL, Louisiana State Lm

Umi

Bto

Rouge

1:30 K169. Detection of Phospho- MurNAc- Pentape.ptide -l iainN'. case by Photoaffinity -Labeled tiDP-NMurNAc-PentapepidC~ S B. BERES* and F. C. NEUHAUS. Northwestern Lnr. Evanston, Ill. K170. Isolation and Characterization of Selenohipoic AcidResistant Mutants of Escherichiu coli. K. E REED* and 3 F CRONAN, JR. Univ. of Illinois, Urbana. K171. Menaquinone (Vitamin K,2 ) Biosynthesýis_ Locali~aitioi. Cloning. and Sequencing of the rnenE Gene of Esch..rihi uoh V. SHARMA,* M. E. S. HUDSPETH, and R_ MFiANATHAN. Northern Illinois Univ.. DeKalb. K172. Oxygen- Regulated Steps in the Rhodobacier capsuiatuii Biosynthetic Pathway. A J. BIEL Depti (if Louisiana State Univ.. Baton Rouge.

2:30 K173. Unusual Pleiotropic Effects of Insertion Mutation" in pdxH of Escherichia coli K-12. H.-M. LAM* and 1, E-, WINKLER. Dept. of Microbiol. and Molecular Genetics. Univ. of Texas Med. Sch., Houston. K174. Molecular Characterization of the cobA Gene of Salnimnella typhimuriurn. S.-J. SUH* and 1. C. [SCAt AN-I'FSEMERENA. Univ. of Wisconsin, Madison. K175. Genetic and Physical Analysis of the Nucleotide Loo-Kp Assembly (CobJII) Functions Required for Cobalamnin lBiosy nthesis in Salmonella typhimurium. G. A. O'TOOLE* and J. C. ESCALANTE-SEMERENA. Univ. of Wisconsin, MadisonI. K176. Purificatioit, Cloning, and Sequence Analysis of the 7oHydroxysteroid Dehydrogenase from Clostridium ahsonumi.). P. COLEMAN,* L. L. HUDSON, and M. .1 AD)AMS Sch of Med., East Carolina Univ., Greenville, N.C.

3:30 K177.

Proline Biosynthesis in StapkvlococcuN aiireik. 1) F

TOWNSEND,' 1.MORROW. and B. J. WILKINSON. Decpt of Biol. Set.. Illinois State Univ.. Normal. K178. Elucidation of the Function of the I-irA (Ssc) l'roiciri Of Escherichia cohb md Salmonella typhimuriuen. J COFI.MAN* and A. M. ROY. Louisiana State Un'.. Med~(Ar 0T Nv.'. Orleans.

GENERAL MEETING 1993. ATLANTA, GA., 16-20 MAY

*

C)Session 294 (BET)

1:30 A 13' .

INNOVATIVE STRAITEGIES FOR TEACHING MiICROBIOLOGYt

1 lcIc i

of f!i

d (i

hs IPenictilant., M(WE"I Lontdoni

I t' 1tt,', ti-01:111

`1

%11

1

%Acidsulfollcý, 1) %1 It%\I (11 1

\cj %1

LIIýllf and J Y Ci)RKII. I Inoi L' K ,.idn Rosal Litser pool no.ll'wI

t, K Saturday, 1:30 i,.%t,. Room 13 Moiienators: 1. FI)WARL) ALICA MO. SU NY ,It Farmingdale,

Farmingdale. N.Y , and JEAN A. DOUTH"WRIGHT. Rochester Inst. ot Techtiologý. Rochester, N.Y.

1:30 Cars I, Award Lecture 'ElJigibh' ]br cofnigeuaincei)Of

A Place for Bacterial D~iversity in the M icrobioltmg) Curriculum: a Plea TO Save an Endartgercd Species JERALD)C. ENSIGN. UniL. of Wisconsin. Madison 2:30

A 138. 1Inducible:J jS-1Tamtani~i-A%IIit i% wd I )wto %1,oJ1 Protein Llccttrophoretic Prmtties III Pa, udo 't. -. RH M RA V-At AR It\( W I than P' ueruidipioA. C ('IRI. l'OMAý and R. '4(RISSL I lotlý-[-thck I,-~ tte a L'it (t de Mt ittrcad IM IN C ,()it:ica Queb. ( 'A I Idj A 139. IS4.actaniasi:N as an tImportamnt Rcestat.n~v \Ic. tat Vt211 I in pencim Resistance in fIn Vi s Sece,ted I~t and J BANt ,Sl1( R(, I ioi% In~ now. K. (IWERCMA-N' timlK MCL. Microhiol and D cpt. of Chn i Cmpcimgll t a DCI )e nta et. State Se rutintIittiutc. tltt Nor , I I ý A140. Contribunon011 of-vMembrane: l'rna mase-Mediated Reosisat,c e, to -ILacain. tit Stitm o!t11 F!, p111' uh1W~~ Isolated 1inCaita11da N (I LXI( I~ I 0

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