2

nd

INTERNATIONAL CONFERENCE

Alma Mater Studiorum Università di Bologna

2nd International Conference

New Drugs in Pediatric Oncology

Bologna, Italy Royal Hotel Carlton January 21-22, 2008 President:

ANDREA PESSION

2nd INTERNATIONAL CONFERENCE

President:

ANDREA PESSION Alma Mater Studiorum Università di Bologna

New Drugs in Pediatric Oncology January 21-22, 2008 Bologna, Italy

ROYAL HOTEL CARLTON VIA MONTEBELLO, 8 40121 BOLOGNA, ITALY TEL.: +39 051 249361 FAX: +39 051 249724

Scientific Secretariat:

Annalisa Astolfi Fraia Melchionda Arcangelo Prete Roberto Tonelli Clinica Pediatrica Università degli Studi di Bologna Policlinico S. Orsola - Malpighi Phone +39 051.346044 email: [email protected]

TOPICS New Antineoplastic Molecules New Drugs for Supportive Therapy New Tools for Drug Discovery & Development

Organizing Secretariat: Studio E.R. Congressi - Gruppo Triumph Via Marconi, 36 - 40122 Bologna Phone +39 051.4210559 - Fax. +39 051.4210174 email: [email protected] www.ercongressi.it 1

2nd INTERNATIONAL CONFERENCE

New Drugs in Pediatric Oncology

Monday, January 21

January 21-22, 2008 Bologna, Italy

08:30-08:45

Opening Ceremony Sergio Stefoni (Dean, Faculty of Medicine, University of Bologna) Augusto Cavina (General Manager, Policlinico S.Orsola-Malpighi)

“Vita brevis, ars longa, occasio praeceps, experimentum periculosum, iudicium difficile”.

Keynote I New Tools for Drug Discovery & Development Chairmen: Maurizio Aricò (Palermo, I) - Andrea Biondi (Milano, I) 08:45-09:10

Orphan Drugs for Orphan Diseases Domenica Taruscio (Roma, I)

09:10-09:35

EMEA/FDA Process for Orphan Drug Designation Frida Rivière (London, UK)

09:35-10:00

System Biology for Target Identification Gastone Castellani (Bologna, I - Providence, USA)

10:00-10:25

Oligonucleotides Therapeutics: Small RNAs Arndt Borkhardt (Dusserdolf, D)

10:25-10:45

Coffee Break

Ippocrate

2

3

2nd INTERNATIONAL CONFERENCE

New Drugs in Pediatric Oncology January 21-22, 2008 Bologna, Italy

Keynote II New Drugs for Hemopoietic Stem Cell Transplantation Chairmen: Franca Fagioli (Torino, I) - Franco Locatelli (Pavia, I) Chairmen: Achille Iolascon (Napoli, I) - Giuseppe Basso (Padova, I) 10:45-11:10

14:00-14:30

LECTURE: New Aspects of Cell Therapy and Cell Manipulation Francesco Frassoni (Genova, I)

14:30-14:50

ATG Christina Peters (Wien, A)

14:50-15:10

The New Intravenous Busulfan Dosing Strategy as Part of Conditioning Regimen in Children: Feasibility and Efficacy Arcangelo Prete (Bologna, I)

15:10-15:30

Treosulfan: a New Agent for Conditioning Regimen in Pediatric Patients Maria Ester Bernardo (Pavia, I)

15:30-15:50

Coffee Break

Sulforaphane: a Promising Example of Multi-Target Therapeutics Patrizia Hrelia (Bologna, I)

11:10-11:35

Genetically Engineered Mouse Models for Pediatric Cancer Daniel W. Fults (Salt Lake City, USA)

11:35-12:00

New Development in Pharmacogenomics Dirk Juergensen (Frankfurt Am Main, D)

12:00-12:25

Pharmacogenomic Drives Toward Individualizing Therapy Leo Kager (Wien, A)

12:25-14:00

Lunch

4

5

2nd INTERNATIONAL CONFERENCE

New Drugs in Pediatric Oncology January 21-22, 2008 Bologna, Italy

Tuesday, January 22 Keynote III New Drugs for Solid Tumors

Keynote II Supportive Therapy

Chairmen: Riccardo Riccardi (Roma, I) - Roberto Luksch (Milano, I)

Chairmen: Mario Renato Rossi (Monza, I) Simonetta Baroncini (Bologna, I) 15:50-16:20

LECTURE: Septifast: a New Tool for the Diagnosis of Bloodstream Infection Massimo Clementi (Milano, I)

16:20-16:40

New Molecules for Invasive Fungal Infection Claudio Viscoli (Genova, I)

16:40-17:00

Posaconazolo Pier Luigi Viale (Udine, I)

17:00-17:20

Protein C Concentrate in Pediatric Patients with Sepsis Roberto Rondelli (Bologna, I)

17:20-17:40

Mechanism-Based Pain Treatment: VEGF? Valeria Fabiola Bachiocco (Bologna, I)

17:40-18:00

Role of Pegfilgrastim in the Supportive Care of Onco-Hematological Patients Simone Cesaro (Padova, I)

6

08:30-09:00

LECTURE: PIM Kinases as Potential Targets for the Treatment of Hematopoietic Malignancies and Solid Cancers Juerg Schwaller (Basel, CH)

09:00-09:20

Pegylated Liposomal Doxorubicine for Refractory Pediatric Cancer Fraia Melchionda (Bologna, I)

09:20-09:40

Imatinib Mesylate for Neuroblastoma Alberto Garaventa (Genova, I)

09:40-10:00

Potential Role of Bevacizumab for Treatment of Sarcomas Michela Casanova (Milano, I)

10:00-10:20

Oligonucleotides Therapeutics: PNAs Roberto Tonelli (Bologna, I)

10:20-10:40

Coffee Break

7

2nd INTERNATIONAL CONFERENCE

2nd INTERNATIONAL CONFERENCE

New Drugs in Pediatric Oncology

New Drugs in Pediatric Oncology

January 21-22, 2008 Bologna, Italy

January 21-22, 2008 Bologna, Italy

Keynote IV New Drugs for Leukemias and Lymphomas Chairmen: Valentino Conter (Monza, I) Gertian Kasper (Amsterdam, NL) 10:40-11:10

LECTURE: Ongoing EU Trials in Pediatric Leukemias Gertjan Kaspers (Amsterdam, NL)

11:10-11:30

Clofarabine, Alone or in Combination Therapy, for Children with Relapsed/Refractory Acute Leukemias Franco Locatelli (Pavia, I)

11:30-11:50

Profile an Potential Role of Liposomal-Encapsulated Doxorubicin Maria Elena Cantarini (Bologna, I)

11:50-12:10

FLT3 Inhibitors Giovanni Martinelli (Bologna, I)

12:10-12:30

Arsenic Trioxide Francesco Lo Coco (Roma, I)

12:30-13:00

Closing Remarks Maurizio Aricò (Palermo, I)

8

2nd INTERNATIONAL CONFERENCE

New Drugs in Pediatric Oncology GENERAL INFORMATION

TRAVEL AGENCY

January 21-22, 2008 Bologna, Italy

ROYAL HOTEL CARLTON Via Montebello, 8 40121 Bologna, Italy Phone +39 - 051 249361 Fax +39 - 051 249724

Bononia Viaggi Piazza Martiri, 1 - 40122 Bologna Italy Phone +39 - 051 4211585 Fax +39 - 051 249846 [email protected]

HOW TO GET THERE

HOTEL RESERVATION

By car

Category

By taxi By bus

From the motorway, turn into the ring road ("Tangenziale") - Exit 7 “Fiera” and follow direction city center and railway station. From the airport about 30 minutes. Bus 91 and Aerobus from the airport. From the railway station walking distance.

4 STARS

Double Single Use

MIN.

MIN.

MAX.

Euro 73,00

Euro 93,00

Euro 159,00

Double Euro 189,00

Reservation fee 20,00 € per room. Prices are inclusive of tax service and breakfast, per room per night. Please fill in the hotel reservation form and send it to the official travel agency Bononia Viaggi before December 30th, 2007. Hotel reservation can only be accepted and confirmed when the form and the confirmatory deposit (the price of one night per room in the selected hotel category plus 20,00€ for agency rights) have been received by Bononia Viaggi. Payments must be done in Euro net of all bank charges and made out to Bononia Viaggi S.r.l. Please pay by:

OFFICIAL LANGUAGE English.

REGISTRATION FEE Euro 100,00

Single

The registration fee includes: · Conference kit · Participation in the scientific sessions · Attendance Certificate · Coffee breaks · Lunch

* Eurocheque or Foreign Cheque * Bank transfer made out to Bononia Viaggi S.r.l. - Account n° 9000/2 - Banca Popolare Emilia Romagna ABI 05387 - CAB 02402 - C/c 00000062332 cin Z - iban IT80Z0538702402000000062332 - swift BPMOIT22XXX

REGISTRATION

❐ Credit Card: Number

Registrations can only be accepted and confirmed after the registration form and fee have been received by the Organizing Secretariat, Studio E.R. Congressi. All payments must be done in Euro net of all bank charges and made out to Studio E.R. Congressi S.r.l. Please pay by: * Eurocheque or Foreign Cheque * Bank Transfer * Credit Card

_______________________

Expiry date

_______________________

Owner

_______________________

Date of birth _______________________

It will not be possible to accept payments by Credit Cards as registration on site. Please send a copy of the bank transfer with the registration form. In case of written cancellation before December 30th, 2007, 80% of the registration fee will be refunded.

❐ VISA

❐ MASTERCARD

❐ DINERS

❐ AMERICAN EXPRESS

* Credit card Please send a copy of the bank transfer with the hotel reservation form. In case of written cancellation before December 30th, 2007, 80% of the fee will be refunded.

10

11

SCIENTIFIC INFORMATION

2nd INTERNATIONAL CONFERENCE

2nd INTERNATIONAL CONFERENCE

New Drugs in Pediatric Oncology

New Drugs in Pediatric Oncology REGISTRATION FORM

January 21-22, 2008 Bologna, Italy

January 21-22, 2008 Bologna, Italy

Please, return this form to: Studio E.R. Congressi - Via Marconi 36 40122 Bologna BO Italy Phone +39 - 051 4210559 Fax +39 - 051 4210174 [email protected]

Slides Slides must be in English. Computer videoprojection will be available in Power Point. Other requirements should be communicated to the Organizing Secretariat as soon as possible. Slides should be handed to the slide center one hour before the beginning of the session and collected at the end.

LAST NAME FIRST NAME ISTITUTION /DEPARTMENT

Badge All registered participants and speakers will be given a badge which they must wear to be admitted to the scientific sessions.

PROFESSION DISCIPLINE

Attendance certificate A certificate will be given to all participants at the end of the Meeting.

PRIVATE ADDRESS

STATE/PROVINCE

CME credits

ZIP

Accreditation has been requested for M.D: Category working in oncology, pediatrics and hematology.

TELEPHONE

FAX

Changes

MOBILE PHONE

E-MAIL

Parts of the programme may be changed if necessary.

CODICE FISCALE

CITY

COUNTRY

FOR THE INVOICE: LAST NAME FIRST NAME PRIVATE ADDRESS CITY COUNTRY VAT NUMBER (P. IVA) TAX PAYER’S NUMBER (COD. FISCALE)

✂

12

STATE/PROVINCE

ZIP

2nd INTERNATIONAL CONFERENCE

2nd INTERNATIONAL CONFERENCE

New Drugs in Pediatric Oncology

New Drugs in Pediatric Oncology

REGISTRATION FORM

January 21-22, 2008 Bologna, Italy

HOTEL RESERVATION FORM Bononia Viaggi Piazza Martiri, 1 40122 Bologna Italy Phone +39 - 051 4211585 Fax +39 - 051 249846 [email protected]

REGISTRATION FEE (in Euro - VAT included): Euro 100,00

PAYMENT

LAST NAME

❐ I enclose Eurocheque or Foreign Cheque of Euro

FIRST NAME Number

INSTITUTION

Bank made out to Studio E.R. Congressi S.r.l. ❐ Bank Transfer made out to Studio Er Congressi S.r.l. Cassa Risparmio di Cesena, Agenzia no. 29, Via Largo Caduti del Lavoro n° 1/A - 40122 Bologna- Italy ABI 06120 - CAB 02400 - Account 000000002596 cin J - iban code IT36J 06120 02400 000000002596 - swift code CECRIT 2C ❐ Credit Card:

Number ___________________________________ Expiry date

ADDRESS

_______________________

Owner ____________________________________ Date of birth _______________________ ❐ VISA

❐ MASTERCARD

❐ DINERS

CITY

STATE/PROVINCE

ZIP

COUNTRY

TELEPHONE

FAX

E-MAIL

❐ AMERICAN EXPRESS

I enclose a copy of the bank transfer with the registration form. Registrations can only be accepted and confirmed when the registration form and fee have been received by the Organizing Secretariat Studio E.R. Congressi. In case of written cancellation before December 30th, 2007, 80% of the registration fee will be refunded. It will not be possible to accept payments by Credit Cards as registration on site.

FOR THE INVOICE:

CITY

STATE/PROVINCE

Signing this form and well informed on the Legislative Decree n. 196/2003 concerning “Personal data processing”, I authorize Studio ER Congressi S.r.l. - Gruppo Triumph until written revocation, to process and divulge my personal data within the limits of the above-mentioned law and in accordance with the proce-dure laid down by the law. I give my assent provided that Studio ER Congressi S.r.l. - Gruppo Triumph complies with the regulations in force. ❐ I do not want that my personal data are divulged to third parties.

ZIP

COUNTRY

PRIVATE ADDRESS

TELEPHONE VAT NUMBER (IVA) TAX PAYER’S NUMBER (COD. FISCALE) NAME OF THE ACCOMPANYING PERSON

SIGNATURE

✂

DATE

January 21-22, 2008 Bologna, Italy

2nd INTERNATIONAL CONFERENCE

New Drugs in Pediatric Oncology HOTEL RESERVATION FORM

January 21-22, 2008 Bologna, Italy

HOTEL RESERVATION Category 4 STARS

Single

Double Single Use

MIN.

MIN.

MAX.

Double

Euro 73,00

Euro 93,00

Euro 159,00

Euro 189,00

These prices are per night per room and include bed, breakfast and taxes. Reservation fee 20,00 €.

HOTEL RESERVATION ❐ 4 stars ❐ Single

❐ Double

Date of arrival

❐ Double Single Use Date of departure

In case of double room, indicate the name of your room-mate

PAYMENT ❐ I enclose Eurocheque or Foreign Cheque of: Euro Number Bank made out to Bononia Viaggi S.r.l. ❐ Bank Transfer made out to Bononia Viaggi S.r.l. - Banca Popolare Emilia Romagna ABI 05387 - CAB 02402 - C/c 00000062332 cin Z - iban IT80Z0538702402000000062332 - swift BPMOIT22XXX ❐ Credit Card: Number ___________________________________ Expiry date _______________________ Owner ❐ VISA

___________________________________ Date of birth _______________________ ❐ MASTERCARD

❐ DINERS

❐ AMERICAN EXPRESS

I enclose a copy of the bank transfer with the hotel reservation form. Hotel reservation can only be accepted and confirmed when the form and the confirmatory deposit (the price of one night per room in the selected hotel category plus Euro 20,00 for agency rights) have been received by Bononia Viaggi. In case of written cancellation before December 30th, 2007, 80% will be refunded. Signing this form and well informed on the Legislative Decree n. 196/2003 concerning “Personal data processing”, I authorize Bononia Viaggi S.r.l., until written revocation, to process and divulge my personal data within the limits of the above-mentioned law and in accordance with the procedure laid down by the law. I give my assent provided that Bononia Viaggi complies with the regulations in force.

❐ I do not want that my personal data are divulged to third parties.

DATE

SIGNATURE

INFORMATION ON LEGISLATIVE DECREE N. 196/2003 According to art. 13, Legislative decree no. 196/2003, and in relation to the processing of personal data, Studio E.R. Congressi S.r.l. inform you of the following: l. Data processing purposes Your personal data will be processed by Studio E.R. Congressi S.r.l. for managing, accounting, statistical, commercial, marketing and/or promo-ting purposes and this by processing, comparing, divulging or employing these very data. 2. Data Processing modality Data will be processed by appropriate devices ensuring their security and confidentiality. Data could be also processed by automatic machines employed to process, store and transmit the very data. 3. Obligatoriness of personal data bestowal To be registered in the congresses we organize, you are obligated to give your data. 4. Data communication, diffusion and transfer Your data can be given to organizers of the congress and to the companies sponsoring the event as well as to other companies, authorities, consor-tia or associations that could divulge these data to their members, users and other related people within the limits of their institutional purposes. The only objective is to inform the person concerned about the existence of similar initiatives or to supply him with other information that could be deemed interesting. Furthermore, the above mentioned data can be given/divulged to companies, authorities, consortia and association working in Italy or in the EC countries having the same objectives as stated before. 5. Rights of interested parties You have the right to know, consulting the register specified in the art. 154 sub-section 1 letter l) of the legislative decree 196/2003, the existence of data processing; you can partially or entirely oppose, for legitimate reasons, the processing of your data, even if these data are relevant to the objecti-ve of data collection. Furthermore you can prevent his data from being used for commercial purposes, market surveys, advertisement for direct selling or interactive commercials. You are acknowledged exercise of rights as per art. 7, Legislative decree 196/2003, the complete text of which is given in the enclosure. 6. The owner of the data processing The owner of the data processing is Studio E.R. Congressi S.r.l. via Marconi,36 - 40122 Bologna. The list of the people responsible of the processing itself is kept updated, and you can easily consult it sending a written communication to the above address. Data will be held into the Studio E.R. Congressi S.r.l. building, as long as the law prescribes. Article 7 of the legislative decree 196/2003 - right of access to personal data and other rights 1. The person concerned has the right to obtain confirmation of the existence of personal data and information regarding him/her - even though not recorded yet - and their disclosure under an intelligible form. 2. The person concerned is entitled to be informed of: a) the origin of personal data and information; b) data treatment purposes and ways; c) the logic followed in the event of data treatment being carried out with electronic tools; d) the details to identify the owner, the persons in charge and the representative appointed under article 5, paragraph 2; e) the people or groups of people to whom personal data and information can be disclosed or who may come to know them in their capacity as repre-sentative appointed in the State territory or persons in charge. 3. The person concerned has the right to obtain: a) updating, correction or - where interested in this process - supplementation of data; b) cancellation, turning into anonymous data or the block of data treated by infringing the law, including data and information which need not be kept in relation to the purposes for which data and information were collected or subsequently treated; c) a certificate stating that the operations under sub-paragraphs a) and b) - including their content - have been communicated to those to whom data and information were provided or disclosed, except the case when this proves to be impossible or entails the use of such an amount of means which is overtly non commensurate with the right which is protected. 4. The person concerned has to right to wholly or partially refuse: a) treatment of personal data and information regarding him/her for legitimate reasons, even though they are relevant to the aim of collection; b) treatment of personal data regarding him/her for the purposes of sending advertising material, direct sale or performance of market studies or com-mercial communications.

project © www.struchel.com

Scientific Secretariat:

Annalisa Astolfi Fraia Melchionda Arcangelo Prete Roberto Tonelli Clinica Pediatrica Università degli Studi di Bologna Policlinico S. Orsola - Malpighi Phone +39 051.346044 email: [email protected]

Organizing Secretariat: Studio E.R. Congressi - Gruppo Triumph Via Marconi, 36 - 40122 Bologna Phone +39 051.4210559 - Fax. +39 051.4210174 email: [email protected] www.ercongressi.it