Nephrology Dialysis Transplantation

Nephrol Dial Transplant (1998) 13: 820-824 Nephrology Dialysis Transplantation Abstracts Abstracts of the 26th Congress of the Czech Society of Nep...
Author: Spencer Atkins
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Nephrol Dial Transplant (1998) 13: 820-824

Nephrology Dialysis Transplantation

Abstracts

Abstracts of the 26th Congress of the Czech Society of Nephrology, 17-19 November 1996, Brno The effect of long-term administration of a low-protein diet on the metabolic status and progression of chronic renal failure: a multicentre study V. Teplan,1 O. Schiick,1 P. Bubenicek, x O. Mengerova1, 2 3 4 5 Z. Tesafova , J. Hajny , A. Knotek , L. Chladecek , A. Doubravova 6 , P .Moucka7, M. Merta1 , M. Vrzanova9, M. Horackova 10 ; department of Nephrology, Inst.Clin. Exp.Medicine, Prague; HD and Depts of Internal Medicine at 2Ceske Budejovice, 3 Chrudim, "Liberec, 'Pribram, 6 Jindfichuv Hradec, 7 Kolin, and 8~10Depts of Internal Medicine of Charles University Schools of Medicine I, II, III in Prague, Czech Republic The aim of a long-term open prospective randomized study is to monitor the metabolic and nutritional status and progression of chronic renal failure (CRF) using three therapeutic protocols: (a) a low-protein diet (LPD) with 0.4 g P/kg/day with keto amino acids, (b) LPD with 0.6 g P/kg/day, and (c) slightly restricted diet with 0.8-1.0 g P/kg/day. A total of 105 patients (50 M, 55 F, aged 26-78 years, Scr 242-526 umol/1) were monitored for 3 years in the three study subgroups (A 35, B 38, and C 32 patients). Exclusion criteria included diabetic nephropathy, failure to co-operate, compliance < 50%, and a severe associated disease (cancer, severe forms of atherosclerosis, chronic infection, and immunosuppression). After a 3-week baseline metabolic stabilization period at the clinic, the metabolic status and renal function were followed up at a 3-month interval on an outpatient basis. A PC program called DIETA was developed to prepare long-term dietetic menus. Hypertension was treated in all patients using low-dose ACE inhibitors and newer-generation calciumchannel blockers to a B P ^ , ^ , . < 90 torr. During follow-up, significantly higher levels of Scr, S^a* U urea V, Sp (P

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