N. R. Jagannathan, FNASc, FASc, FAMS, Professor and Head, Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi – 110029, India. Nationality: Indian; born in Chittor, India, 23-06-1954; married with two children.

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SCIENTIFIC SOCIETIES & BODIES: • President, Asian Biophysics Association (ABA) 2011-13 • President, Indian Biophysical Society (IBS) 2007-09 • Member, Executive Council, International Union of Pure and Applied Biophysics (IUPAB) (2008-2011; 2011 -14) Member (Director), Council of the International Conferences on Magnetic Resonance in Biological Systems (ICMRBS). (2005 - 2014). Member, Annual Meeting Program Committee (AMPC), International Society for Magnetic Resonance in Medicine (ISMRM), USA [2007-2010]. Member, Education Committee, International Society for Magnetic Resonance in Medicine (ISMRM), USA [2007-2009]. Member, Chapters Committee, International Society for Magnetic Resonance in Medicine (ISMRM) [2010-11]. Member, Research Council (RC), Center for Cellular & Molecular Biology (CCMB), Hyderabad, India (2007-09). Member, Steering Committee of the Sophisticated Instruments facilities (SAIFs) of Department of Science and Technology (DST), Government of India (2005-2007). Member, Program Advisory Committee (PAC), Section on Biophysics, Biochemistry, Microbiology and Molecular Biology, Department of Science and Technology (DST), Government of India (2007-2010). Coordinator, Expert panel on “Biomedical Devices and Bioengineering”, Life Sciences Research Board (LSRB), DRDO (2003- till date). Member, Facility Management Committee (FMC), Sophisticated Analytical Instruments Facility, Indian Institute of Technology, Madras, Chennai (2007 – till date). Member, Award Committee of Swarnajyanti Fellowship of Department of Science and Technology, DST), Government of India (2006-07). Coordinator, Research Review Committee, AIIMS, New Delhi (2007-08) Member, Indian National Science Academy (INSA) combined committee for International Union of Pure and Applied Biophysics (IUPAB) and International Union of Crystallography (IUCr), (2004-2007) Member, Facility Management Committee (FMC), Sophisticated Instruments Facility, Indian Institute of Science, Bangalore (2004 – 2007).

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Member, Program Advisory Committee (PAC), National Facility for High Field NMR, Tata Institute of Fundamental Research (TIFR), Bombay (1993 – till date). Member, Indian National Science Academy (INSA) committee for International Union of Pure and Applied Biophysics (IUPAB), 2001- 2003. Member, Center Management Committee (CMC), RSIC, Central Drug Research Institute (CDRI), Lucknow (2000 - 2003) Secretary, National Magnetic Resonance Society (NMRS) (1998 - 2001). Member, National Organizing Committee (NOC) constituted by INSA for the conduct of the IUPAB CONGRESS held in India during September 19-24, 1999. Member, Center Management Committee (CMC), Sophisticated Instruments Facility, Indian Institute of Science, Bangalore (1997 - 2000).

FELLOWSHIP OF SCIENTIFIC ACADEMIES & SOCIETIES • Fellow, National Academy of Sciences (FNASc), Allahabad, India • Fellow, Indian Academy of Sciences (FASc), Bangalore, India • Fellow, National Academy of Medical Sciences (FAMS), New Delhi, India • Fellow, International Society for Magnetic Resonance in Medicine (ISMRM), USA AWARDS: E. K. Zavoisky Stipend, International Society for Magnetic Resonance in Medicine (ISMRM), Stockholm, 2010; E. K. Zavoisky Stipend, International Society for Magnetic Resonance in Medicine (ISMRM), Honolulu, 2009; International travel grant, Biophysical Society, USA, 2008; E. K. Zavoisky Stipend, International Society for Magnetic Resonance in Medicine (ISMRM), Toronto, 2008; E. K. Zavoisky Stipend, International Society for Magnetic Resonance in Medicine (ISMRM), Berlin, 2007; E. K. Zavoisky Stipend, International Society for Magnetic Resonance in Medicine (ISMRM), Seattle, USA, 2006; Platinum Jubilee Lecturer, Indian Science Congress, 2000; Bruker Young Scientist, 1993; INSA Research Fellow (1990-92) - Awarded for outstanding contribution in the field of science for scientists below the age of 40 years by the Indian National Science Academy (INSA) 1989; NATO study award, 1983.

MEMBER OF EDITORIAL BOARDS OF: (1) NMR Biomedicine, John Wiley &Sons; (2) Deputy Editor, Neuroscience Imaging, Nova Publishers; (3) MAGMA (Magnetic Resonance Materials in Physics, Biology and Medicine), Springer; (4) Magn. Reson. Imaging, Elsevier; (5) Biophys. Rev.; Springer; (6) Member, Editorial Board, “Magn Reson Insights” (Libertas Academica, USA); (7) Member, Editorial Board, “Spectroscopy – Biomedical Applications” (IOS Press, Netherlands)

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BOOKS, VOLUMES EDITED, ETC. (1) Recent Advances in MR Imaging and Spectroscopy, Jaypee; (2) Biomedical Magnetic Resonance: Proceedings of the International Workshop, Jaypee; (3) MRI and MR Spectroscopy in Pharmaceutical and Clinical Research, Jaypee; (4) MRI and in-vivo NMR", (Guest Editor) special issue Current Science; (5) Special Issue Editor, "Tumor Microenvironment in Cancer Treatment and Metastasis” in NMR in BIOMEDICINE [2011: 24 (6); 559-764. 2011]; and (6) Special Issue Editor, "Breast MR” in NMR in BIOMEDICINE, [Volume 22(1), pages 1-136; 2009]. PUBLICATIONS SINCE 2008: •

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The potential of magnetic resonance spectroscopic imaging in predicting absence of prostate cancer in men with serum prostate specific antigen between 4-10 ng/ml: a followup study. Kumar R., Kumar V., Jagannathan N. R., Thulkar S., Gupta S. D, Dwivedi S.N.,. Hemal A.K, and Gupta N.P. Urology, 2008; 72: 859-63. Evaluation of the role of magnetization transfer imaging (MTI) in prostate: A preliminary study. Kumar V., Jagannathan N.R, Kumar R., Thulkar S., Gupta S. D., Dwivedi S.N., Hemal A.K., and Gupta N.P. Magn. Reson. Imaging, 2008; 26: 644-649. In vivo proton spectroscopy of giant cell tumor of the bone. Sah P. L., Sharma R., Kandpal H., Seith A., Rastogi S., Bandhu S., Jagannathan N. R. AJR Am. J. Roentgenol., 2008; 190:W133-9. Structural elucidation of 4'-epiadriamycin by nuclear magnetic resonance spectroscopy and comparison with adriamycin and daunomycin using quantum mechanical and restrained molecular dynamics approach. Barthwal R, Agrawal P, Tripathi A. N, Sharma U, Jagannathan N. R, Govil G. Arch. Biochem. Biophys., 2008; 474: 48-64. Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. Dohare P, Garg P, Sharma U, Jagannathan N.R., Ray M. BMC Complement Altern. Med., 2008, 8:55-106. Curcuma Oil: Reduces Early Accumulation of Oxidative Product and is Anti-apoptogenic in Transient Focal Ischemia in Rat Brain. Rathore P, Dohare P, Varma S, Ray A, Sharma U, Jagannathan N.R., Ray M. Neurochem. Res., 2008, 33,1672–1682. Longitudinal study of the assessment of tumor response of locally advanced breast cancer patients undergoing neo-adjuvant chemotherapy by MR imaging and diffusion weighted imaging. Sharma U., Danishad K. A., Seenu V. and Jagannathan N. R. NMR Biomed., 2009, 22: 104-113. Investigation of hepatic gluconeogenesis pathway in non-diabetic Asian Indians with nonalcoholic fatty liver disease using in vivo (31P) phosphorus magnetic resonance spectroscopy. Sharma, R, Sinha S, Danishad K. A., Vikram N K, Gupta A, Ahuja V, Jagannathan N. R., Pandey R. M., Misra A. Atherosclerosis, 2009, 203, 291-7.

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Metabolism of colonic mucosa in patients with inflammatory bowel diseases (IBD): An proton in vitro MR spectroscopy study. Balasubramanian K, Kumar S, Singh R.R, Sharma U, Ahuja V, Makharia G. M, Jagannathan N. R. Magn. Reson. Imaging, 2009, 27, 79-86. Proton MR spectroscopy (MRS) and biochemical investigation of type 2 diabetes mellitus in Asian Indians: Observation of high muscle lipids and C-reactive protein (CRP) levels. Sinha S, Misra A, Rathi M, Kumar V, Pandey R M, Luthra K, Jagannathan N. R. Magn. Reson. Imaging, 2009, 27, 94-100. Proton magnetic resonance spectroscopy of brain to study the cerebral abnormalities in COPD patients: A case control study in North India. Sinha S, Kumar V, Jagannathan N. R., Pandey RM. Ind. J. Chest Dis. Allied Sci., 2009; 51: 15-20. Study of normal breast tissue by in vivo volume localized proton MR spectroscopy (MRS): Variation of water - fat (W-F) ratio in relation to the heterogeneity of the breast and the menstrual cycle. Sharma U, Kumar M, Sah R.G., and Jagannathan N. R. Magn. Reson. Imaging, 2009; 27: 785-791. Potential of 1H MR spectroscopic imaging to segregate patients who are likely to show malignancy of the peripheral zone of the prostate on biopsy. Kumar V., Jagannathan N. R., Kumar R., Nayyar R., Thulkar S., Gupta S. D.,. Dwivedi S.N, Hemal A.K., and Gupta N.P. J. Magn. Reson. Imaging, 2009; 30: 842-8. Effect of vineatrol in focal cerebral ischemia in rats. Briyal S, Sharma U, Jagannathan N.R., Gupta YK. Methods Find Exp. Clin. Pharmacol. 2009; 31:505-511. Tamoxifen-2-hydroxylpropyl-beta-cyclodextrin-aggregated nanoassembly for nonbreast estrogen-receptor-positive cancer therapy. Shukla J, Sharma U, Kar R, Juyal S, Jagannathan N. R. and Bandopadhyaya G. P. Nanomedicine, 2009; 4: 895-902. Assessment of therapeutic response of locally advanced breast cancer (LABC) patients undergoing neoadjuvant chemotherapy (NACT) monitored using sequential magnetic resonance spectroscopic imaging (MRSI). Danishad K. A., Sharma U., Sah R. G., Parshad R., Seenu V. and Jagannathan N. R. NMR Biomed., 2010; 23: 233-41. Effect of Creatine Monohydrate (Cr) in improving cellular energetics and muscle strength in ambulatory Duchenne Muscular Dystrophy (DMD) patients: A Randomized placebo controlled 31P MRS study. Banerjee, B., Sharma U., Balasubramanian K., Kalaivani M., Kalra V. and Jagannathan N.R. Magn. Reson. Imaging, 2010; 28: 698-707. Similarity in the metabolic profile in macroscopically involved and un-involved colonic mucosa in patients with inflammatory bowel disease: an in vitro proton 1H MR spectroscopy study. Sharma U, Singh R.R, Ahuja V, Makharia G.K, and Jagannathan N.R. Magn. Reson. Imaging. 2010, 28: 1022-29. Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D deficient Asian Indian: A randomized controlled study. Gupta R, Sharma U, Gupta N, Kalivani M, Singh U, Guleria R, Jagannathan N. R., and Goswami R. Clin. Endocrinol., 2010, 73: 445-51.

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Magnetic resonance imaging evaluation of subarachnoid hemorrhage in rats and the effects of intra-cisternal injection of papaverine and nitroglycerine in the management of cerebral vasospasm – An experimental study. Ramdurg S.R, Suri A, Gupta D, Mewar S, Sharma U, Jagannathan N.R, and Sharma B.S. Neurology India, 2010, 58: 377-383. Proton magnetic resonance spectroscopy of brain in obstructive sleep apnoea in north Indian Asian subjects. Sharma Surendra K., Sinha S., Danishad K.A., Sharma U., Sharma H., Mishra H.K., Mishra H., Kadhiravan T., Reddy V.V., Sreenivas V. and Jagannathan N.R., Ind. J. Med. Res., 2010, 132: 278-286. Magnetic resonance spectroscopy in ring enhancing lesions. Seth R, Kalra V, Sharma U, Jagannathan N. R. Ind. Pediatr., 2010, 47: 803-4. Composite polymeric magnetic nanoparticles for co-delivery of hydrophobic and hydrophilic anticancer drugs and MRI imaging for cancer therapy. Singh, Abhalaxmi; Dilnawaz F, Mewar S, Sharma U, Jagannathan N. R., Sahoo S. ACS Appl. Mater. Interfaces, 2011, 3: 842-56. DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma. Singhal G., Akhter M.Z., Stern D.F., Gupta SD, Ahuja A, Sharma U, Jagannathan N.R., and Rajeswari M.R. Cancer Gene Ther. 2011, 18, 520-30. Superparamagnetic nanosystems based on iron oxide nanoparticles and mesoporous silica: Synthesisand evaluation of their magnetic, relaxometric and biocompatability properties. Gandhi S, Venkatesh S, Sharma U, Jagannathan N. R., Sethuraman S and Krishnan U. M. J. Mat. Chem. DOI: 10.1039/c1jm12500a. Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats. Chauhan A, Sharma U, Jagannathan N. R., Reeta K. H., and Gupta Y.K. Behavioural Brain Res. 2011; 225, 603– 609. Association of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor 2 Status with total Choline Concentration and Tumor volume in Breast Cancer Patients: An MRI and In Vivo Proton MRS Study. Sah R. G., Sharma U., Parshad R., Seenu V. Mathur, S. and Jagannathan N. R. Magn. Reson. Med. 2011 Dec 28. doi: 10.1002/mrm.24117. [Epub ahead of print]. The transport of non-surfactant based paclitaxel loaded magnetic nanoparticles across the blood brain barrier in a rat model. Dilnawaz F, Singh A, Mewar S, Sharma U, Jagannathan N.R., Sahoo SK. Biomaterials 2012 Apr; 33(10): 2936-51. Epub 2012 Jan 20.

REVIEW ARTICLES SINCE 2008 • Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective. Jagannathan N. R., Kumar V., Kumar R. and Thulkar S. Magn. Reson. Mat. Phys. Biol. Med. (MAGMA) 2008, 21, 393-407; Erratum 2008, 21, 409.

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• Biochemical Characterization of Breast Tumors by in vivo and in vitro Magnetic Resonance Spectroscopy (MRS). Sharma U and Jagannathan N. R. Biophys. Rev. 2009, 1, 21-26. • Magnetic resonance spectroscopic imaging: current status in the management of prostate cancer. Nayyar R, Kumar R, Kumar V, Jagannathan N. R, Gupta NP and Hemal A. K. BJU Int. 2009; 103, 1614-20. • Breast magnetic resonance spectroscopy (Breast MRS). Sharma U and Jagannathan N. R. In: Encyclopedia of Magnetic Resonance, eds. R. K. Harris and R. E. Wasylishen, John Wiley: Chichester. DOI: 10.1002/9780470034590.emrstm1167. Published 15th December 2009. • Breast magnetic resonance imaging (Breast MRI). Sharma U, Sharma R and Jagannathan N. R. Encyclopedia of Magnetic Resonance, eds R. K. Harris and R. E. Wasylishen, John Wiley: Chichester. DOI: 10.1002/9780470034590.emrstm0045.pub2. Published 15th March 2010. • In vivo 1H MR spectroscopy in the assessment of the therapeutic response of breast cancer patients. Sharma U, Baek H.M, Su M.Y, and Jagannathan N. R. NMR Biomed. 2011; 24, 700-711. • Breast tissue characterization by in vivo magnetic resonance spectroscopy (MRS). Jagannathan N. R. Spectroscopy (2011); 25, 251–260. • Pre-biopsy magnetic resonance spectroscopy and imaging in the diagnosis of prostate cancer. Kumar V, Jagannathan N.R, Thulkar S and Kumar R. Int. J.Urol. (Accepted).

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