Natalia Palacios Curriculum Vitae Office Address:

Harvard School of Public Health Building 2, Room 341 655 Huntington Avenue Boston, Massachusetts 02115

Phone:

+1 (617) 304 4254

Email:

[email protected]

FAX:

+1 (617) 432 2435

EDUCATION Undergraduate Graduate

B.A. Rice University, Biochemistry, Magna Cum Laude, Phi Beta Kappa, 2003 M.Sc. Epidemiology, Harvard School of Public Health, 2005 Sc.D. Nutritional Epidemiology, Harvard School of Public Health, 2008

POSTGRADUATE TRAINING Research Fellow, Department of Epidemiology, Harvard School of Public 2008-2010 Health Research Associate, Department of Nutrition, Harvard School of Public 2010-2012 Health ACADEMIC APPOINTMENTS 2014-present 2012-present

Research Scientist, Department of Nutrition, Harvard School of Public Health Instructor in Medicine, Harvard Medical School

OTHER PROFESSIONAL POSITIONS 05/00-09/00 06/01-09/01 07/02-09/02

Summer Research Intern, UNC Chapel Hill, School of Medicine Software Test Engineer Intern, Microsoft Corporation Summer Research Intern, Harvard School of Public Health

MEMBERSHIP IN PROFESSIONAL SOCIETIES 2005-present 2007-present 2008-present

Member, American Academy of Neurology Member, Society of Epidemiologic Research Member, American Association for the Advancement of Science 1

2008-present 2011-present

Member, Movement Disorder Society International Society of Environmental Epidemiology

EDITORIAL ACTIVITIES Ad hoc Reviewer for: American Journal of Epidemiology Movement Disorders Journal Parkinsonism and Related Disorders Pharmacogenomics and Personalized Medicine PLoS One Editorial Board Member: Advances in Epidemiology TEACHING 2006-Present 2010-Present

NUT226, Nutrition Policy, Harvard School of Public Health Graduate Students, 2-hr sessions every 2 weeks for 32 weeks Guest Lecturer, Neuro-Epidemiology, Chronic Disease Epidemiology

Brown

University

course

on

01/00-05/01

Intermediate Programming in Java, (Teaching Assistant) Rice University 2nd year undergraduate Computer Science students One 3-hr session per week for 16 weeks

2005-2007

Introduction to Nutrition (Teaching Assistant), Harvard School of Public Health 1st and 2nd year Nutrition doctoral students Two 2-hr sessions per week for 8 weeks

2005-2007

Nutritional Biochemistry (Teaching Assistant), Harvard School of Public Health 1st and 2nd year Nutrition doctoral students Two 2-hr sessions per week for 8 weeks

2006

Introduction to Epidemiology (Grading Assistant), Harvard School of Public Health, 1st year Epidemiology doctoral students Two 2-hr sessions per week for 4 weeks

HONORS AND AWARDS 2002

National Society of Collegiate Scholars

2002

Golden Key National Honor Society 2

Phi Beta Kappa

2003 RESEARCH GRANTS Awarded 2010-2015

Air pollution and Parkinson disease: a GIS-Based Approach NIEHS/K01 ES019183 Role: PI ($595,786) The major goal of this study is to examine the association between air pollution (derived using Geographical Information Systems (GIS) and risk of Parkinson disease within the Nurses Health Study I, and the Health Professionals Follow-up Study.

2010-2012

The Epidemiology of Chronic Fatigue Syndrome Chronic Fatigue Initiative (Foundation) Role: Project Director ($241,580.87) The major goal of this study is to identify, within three large prospective cohorts of nurses and health professionals, those participants who meet the criteria for Chronic Fatigue Syndrome (CFS), and use these data to conduct epidemiologic analyses in search of risk factors for CFS.

Under Review

Vitamin D and Risk of Parkinson Disease NIEHS R01 Role: PI ($2,789,507) Initially Submitted June 2013, to be Submitted again January 2015 Parkinson disease (PD) is a neurodegenerative disease with no known cure that has a large negative impact on the quality of life of patients, their families, and society. There is consistent evidence that environmental factors strongly influence PD risk. This project will take advantage of longitudinal data collected for over 30 years from three large populations of US health professionals to examine the effects serum and dietary vitamin D and vitamin D related genes on the risk of PD. Air Pollution and Multiple Sclerosis NIEHS R21, Multiple Sclerosis Society Role: PI (budget TBD) Submitted Oct 2013 as R01, to be submitted March 2015 as R21 The cause of MS remains subject to intense investigation, and environmental factors are believed to contribute strongly to MS risk and progression. In the proposed study, we will use two well-established prospective cohorts of US women with well-validated pollution-exposure models in an attempt to answer the

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question whether exposure to air pollution contributes to MS risk and progression. We will supplement and replicate this effort in GEMS, an innovative study of first-degree relatives of MS patients that will allow us to examine whether pollution could increase risk of MS among a genetically susceptible population. SUPERVISORY ROLES Supervision of study programmer / Harvard School of Public Health, Boston, MA 2011-present

Weekly mentorship (ongoing)

INTERDISCIPLINARY COLLABORATIONS 2009-2010

Consultant for a project setting up an online patient database at the MIT Media Lab, Massachusetts Institute of Technology, Cambridge MA

INVITED PRESENTATIONS Regional 2005

Prospective Study of Amyotrophic Lateral Sclerosis (ALS) within the CPS II cohort. Neuroepidemiology Research group, Harvard School of Public Health. Boston, MA

2006

Modeling international gender-specific trends of smoking and Parkinson’s disease. Neuroepidemiology Research Group Meeting, Harvard School of Public Health. Boston, MA

2008

Diet and Amyotrophic Lateral Sclerosis Smoking, Caffeine, Estrogen and Parkinson’s Disease. Invited Talk Department of Nutrition Weekly Seminar, Harvard School of Public Health, Boston, MA

2009

Cigarette smoking and sex ratio of multiple sclerosis. Neuroepidemiology Research Group Meeting, Harvard School of Public Health, Boston MA

2009

Obesity, Diabetes and Risk of Parkinson’s Disease in a Large Prospective Cohort of Men and Women. Neuroepidemiology Research Group Meeting, Harvard School of Public Health, Boston, MA

2009

Introduction to Nutritional Epidemiology. Invited Lecture. Simmons College, Boston, MA

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2010

Alcohol and Risk of Parkinson’s Disease in a Large Prospective Cohort of Men and Women. Neuroepidemiology Research Group Meeting, Harvard School of Public Health, Boston, MA

2011

Chronic Fatigue Syndrome. Invited Talk. Channing Laboratory Lunchtime Seminar, Harvard Medical School, Boston, MA

2012

Chronic Fatigue Syndrome in the Nurses Health Study II. Invited Talk. Channing Laboratory Breakfast Seminar, Harvard Medical School, Boston, MA

2011-2014

Epidemiology of Neurological Disease, Invited Lecture Brown University, Providence RI (2 hour lectures)

National 2008

International 2009

Polymorphisms in caffeine metabolism and estrogen receptor genes and risk of Parkinson’s disease in men and women. (abstract) Annual meeting of the Society of Epidemiologic Research, Chicago IL

Obesity, Diabetes and Risk of Parkinson’s Disease in a Large Prospective Cohort of Men and Women. (abstract) World Federation of Neurology, Seattle, WA

2010

Cigarette smoking and sex ratio of multiple sclerosis. (abstract) Annual meeting of the American Academy of Neurology, Toronto, ON, Canada

2011

Air Pollution and Risk of Parkinson Disease in a Prospective Study of Women. (abstract) International Society for Environmental Epidemiology (ISEE), Barcelona, Spain

2013

Air Pollution and Risk of Multiple Sclerois in a Prospective Study of Women. (abstract) International Society for Environmental Epidemiology (ISEE), Basel, Switzerland

2013

Exposure to Airborne Metals and Risk of Parkinson Disease in a Large Prospective Study of Women. Alzheimers and Parkinson’s Disease Congress, Florence, Italy

EDUCATION OF PATIENTS AND SERVICE TO THE COMMUNITY 2012

Invited Speaker, New Jersey CFS Association's 2012 Medical/Patient conference, October 2012 (sponsor: New Jersey CFS Association)

PUBLICATIONS Original Publications in Peer-Reviewed Journals 5

1. Morozova N, Allers J, Myers J, Shamoo Y. Protein-RNA interactions: exploring binding patterns with a three-dimensional superposition analysis of high resolution structures. Bioinformatics. 2006 Nov 15;22(22):2746-52. 2. Weisskopf MG, McCullough ML, Morozova N, Calle EE, Thun MJ, Ascherio A. Prospective study of occupation and amyotrophic lateral sclerosis mortality. Am J Epidemiol. 2005 Dec 15;162(12):114652. 3. Morozova N, O’Reilly E., Ascherio A. Variations in gender ratios support the connection between smoking and Parkinson disease. Mov Disord. 2008 Jul 30; 23(10):1414-9. 4. Morozova N, Weisskopf MG, McCullough ML, Munger KL, Calle EE, Thun MJ, Ascherio A. Diet and amyotrophic lateral sclerosis. Epidemiology. 2008 Mar;19(2):324-37. 5. Weisskopf MG, Morozova N, O'Reilly EJ, McCullough ML, Calle EE, Thun MJ, Ascherio A. Prospective study of chemical exposures and amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. J Neurol Neurosurg Psychiatry. 2009 May; 80(5): 558-561. 6. Palacios N, Weisskopf M, Simon K, Gao X, Schwarzschild M, Ascherio A. Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson’s disease in men and women Parkinsonism Relat Disord. Parkinsonism Relat Disord. 2010 July; 16(6): 370-375. Published online 2010 March 20. 8. Palacios N, Alonso A, Bronnum-Hansen H, Ascherio A. Smoking and Increased Risk of Multiple Sclerosis: Parallel Trends in the Sex Ratio Reinforce the Evidence. Ann Epidemiol. Ann Epidemiol. 2011 July; 21(7): 536-542. PMCID: PMC3124940 9. Xiang Gao, Kristen Lyall, Palacios N, Walters A, Ascherio A. RLS in middle aged women and attention deficit/hyperactivity disorder in their offspring. Sleep Med. Sleep Med. 2011 January; 12(1): 89-91. 10. Palacios N, Gao X, O'Reilly E, Schwarzschild M, McCullough ML, Mayo T, Gapstur SM, Ascherio AA. Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women. Mov Disord. 2012 Jul;27(8):980-7. 11. Palacios N, Gao X, McCullough ML, Schwarzschild MA, Shah R, Gapstur S, Ascherio A. Caffeine and risk of Parkinson's disease in a large cohort of men and women. Mov Disord. 2012 Sep 1;27(10):1276-82. 12. Palacios N, Xiang Gao, Marjorie L. McCullough, Jacobs E, Patel A, Mayo T, Schwarzschild M.A., Ascherio A. Obesity, Diabetes and Risk of Parkinson Disease. Mov Disord. Author manuscript; available in PMC 2013 April 16.Published in final edited form as: Mov Disord. 2011 October; 26(12): 2253-2259. 13. Palacios N., Simon K., Ascherio A. Smoking and Risk Of Multiple Sclerosis. Multiple Sclerosis and Related Disorders. 1(3) 2012 106-107.

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14. Palacios N, Ascherio A. Reply to: Diabetes and risk of Parkinson's disease. Mov Disord. 2013 Feb;28(2):258. 15. Palacios N, Gao X, Schwarzschild M, Ascherio A. Declining Quality of Life in Parkinson Disease Before and after diagnosis. Journal of Parkinson Disease. 2(2). 153-160. 16. Palaicos N, Fitzgerald KC, Hart JE, Weisskopf MG, Schwarzschild MA, Ascherio A, Laden F. Particulate matter and risk of Parkinson disease in a large prospective study of women. Environ Health. 2014 Oct 7; 13:80. 17. Palacios N, Fitzgerald K, Roberts AL, Hart JE, Weisskopf MG, Schwarzschild MA, Ascherio A, Laden F. A Prospective Analysis of Airborne Metal Exposures and Risk of Parkinson Disease in the Nurses Health Study Cohort. Environmental Health Perspect. 2014. Sep; 122(9):933-8. 18. Palacios N, Fitzgerald K, Komaroff A, Ascherio A. Prevalence of Severe fatigue and Chronic Fatigue Syndrome in a Large Cohort of US Women. Under review at the BMJ Journal of Epidemiology and Community Health. In Progress Publications 19. Palaicos N, Fitzgerald KC, Hart JE, Weisskopf MG, Schwarzschild MA, Ascherio A, Laden F. Particulate matter and risk of Parkinson disease in a large prospective study of men. (in preparation) 20. Palaicos N, Fitzgerald KC, Hart JE, Munger K, Ascherio A, Laden F. Particulate matter and risk of Multiple Sclerosis in a large prospective study of women. (in preparation) 21. Palacios N, Fitzgerald K, Roberts AL, Hart JE, Weisskopf MG, Schwarzschild MA, Ascherio A, Laden F. A Prospective Analysis of Airborne Metal Exposures and Risk of Parkinson Disease in the Health Professionals Follow-up Study (in preparation) 22. Palacios N, Fitzgerald KC, Hart JE, Weisskopf MG, Schwarzschild MA, Ascherio A, Laden F. Particulate matter and Parkinson disease progression and mortality in the Nurses Health Study. (in preparation) 23. Palaicos N, Fitzgerald KC, Hart JE, Weisskopf MG, Schwarzschild MA, Ascherio A, Laden F. Particulate matter and Parkinson disease progression and mortality in the Health Professionals Followup Study. (in preparation)

Doctoral Thesis

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1. Morozova N. “Epidemiology of Neurodegenerative diseases: A) Diet and Amyotrophic Lateral Sclerosis, B) Smoking, caffeine, estrogen and Parkinson’s Disease.” Harvard School of Public Health, Boston, MA; 2008 ABSTRACTS, POSTER PRESENTATION PROFESSIONAL MEETINGS

AND

EXHIBITS

PRESENTED

AT

1. Palacios N, Roberts AL, Weisskopf M, Schwarzschild M, Laden F, Ascherio A. Exposure to Airborne Metals and risk of Parkinson Disease in a Prospective Study of US Women. E-poster presentation. Twenty Fourth Conference of the International Society for Environmental Epidemiology (ISEE); Columbia, South Carolina, USA. 2012 August 2. Palacios N, Chan A, Ascherio A, Willett W, Jacobson B. Oral Contraceptive Use, Parity, Breastfeeding and risk of Irritable Bowel Syndrome in a Large Prospective Study of Women. Poster Presentation at Digestive Diseases Week (DDW). San Diego, CA. 2012 May 3. Palacios N, Gao X, Schwarzschild M, Ascherio A. Declining Quality of Life in Parkinson Disease Patients Before and After Diagnosis. American Academy of Neurology (AAN), 64th Annual Meeting. New Orleans, LA. 2012 April.

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