NANOMATERIALS FOR DRUG DELIVERY AND THERANOSTICS Gold Nanoparticles Silver Nanoparticles Iron Oxide Nanoparticles Carbon Nanotubes Fluorescent Nanodiamonds Silica Nanobeads

Fe3O4 nanoparticles

NANOMATERIALS

DOX-MMNA

MMNA

DSPE-PEG2000 (5:2:2)

DOX:TXL-LMMNA ACMF pH

ACMF

in vitro thermo-chemotherapy with DOX:TXL-LMMNA

in vitro Dual drug release from LMMNA

Nanoparticles of gold, silver, iron oxide, silica, and carbon find B) applications in bioimaging, biosensing and targeted drug delivery.1-4 Appropriate surface modification allows for the conjugation of nanoparticles to a wide range of biomolecules including peptides, antibodies, nucleic acids as well as therapeutic agents. Conjugation to highly specific affinity reagents can enable delivery of nanomaterials and preferential accumulation in the area of interest, leading to enhanced therapeutic efficacy and reduced cytotoxicity. Aldrich® Materials Science offers a wide selection of nanomaterials for biomedical applications.

Magnetic nanoparticles

PEGlyated lipid layer

References 1. Hu, X.; Liu, S. Dalton Trans. 2015, 44, 3904.

Day 7

In vivo biodistribution by imaging in nude mice

Targeting dual drug DOX:TXL-LMMNA

2. Wu,X.; Gao, Y.; Dong, C-M. RSC Adv. 2015, 5, 13787.

Drugs targeting Day 0

3. Xie, J.; Jon, S. Theronastics 2012, 2, 122. 4. Nigam, S.; Pradhan, L.; Bahadur, D. Material Matters, 2015, 10, 29.

Your Partner In Academic Drug Discovery Nanomaterials for Drug Delivery is just one part of Sigma-Aldrich’s complete offer for academic Drug Discovery, a unique series of solutions that span Target ID & Validation through Pre-Clinical Development. Translational Medicine Solutions from Sigma-Aldrich are used by experts and non-experts alike to facilitate the crossdisciplinary research required for today’s drug discovery.

To learn more about solutions that cover the entire drug discovery workflow, visit

TRANSLATIONAL RESEARCH SOLUTIONS

TARGET ID & VALIDATION

aldrich.com/translational

Nanomaterials for Drug Delivery and Theranostics

LEAD DISCOVERY

LEAD OPTIMIZATION

PRE-CLINICAL DEVELOPMENT

CLINICAL DEVELOPMENT

MANUFACTURING

Gold Nanoparticles Used for targeted drug delivery, cell tracking, photothermal therapy, immunoassays, and photocaustic imaging. Includes a variety of attachment chemistries for convenient attachment of biomolecules and other targets. For a complete list of available materials, visit

aldrich.com/gnp Description

Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Carboxylic acid functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Carboxylic acid functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Carboxylic acid functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Carboxylic acid functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O Silica-coated gold nanoparticles, OD 1, dispersion in H2O Silica-coated gold nanoparticles, OD 1, dispersion in H2O Silica-coated gold nanoparticles, OD 1, dispersion in H2O Silica-coated gold nanorods, absorption/780 nm, dispersion in H2O Silica-coated gold nanorods, absorption/808 nm, dispersion in H2O Silica-coated gold nanorods, absorption/850 nm, dispersion in H2O

Particle Size (nm)

Prod. No.

5 10 15 20 30 40

765260 765295 765317 765333 765368 765384

10 20 40 50 5 10 20 10 10 10

765457 765503 765554 765570 747556 747564 747572 747971 747998 748005

Silver Nanoparticles Used for antifouling coating, bioimaging, hyperthermia, and thermally modulated drug release. For a complete list of available materials, visit

aldrich.com/snp

Nanospheres Description Nanospheres, 0.02 mg/mL in water Nanospheres, 0.02 mg/mL in 2 mM aqueous sodium citrate Nanospheres, 0.02 mg/mL in water Nanospheres, 0.02 mg/mL in water Nanospheres, 0.02 mg/mL in water

Surface

Particle Size (nm)

Prod. No.

PVP functionalized Citrate functionalized Lipoic acid functionalized PEG functionalized BPEI functionalized

10 30 40 50 60

795925 796123 796204 796328 796425

Surface

Resonance Wavelength (nm)

Prod. No.

PVP functionalized PVP functionalized PVP functionalized

550 750 850

796476 796492 796506

Nanoplates Description Nanoplates, 0.02 mg/mL (in water with 5 mM sodium borate buffer) Nanoplates, 0.02 mg/mL (in water with 5 mM sodium borate buffer) Nanoplates, 0.02 mg/mL (in water with 5 mM sodium borate buffer)

Iron Oxide Nanoparticles Used as magnetic resonance imaging (MRI) contrast agents, gene carriers for gene therapy, therapeutic agents for hyperthermia-based cancer treatments, magnetic sensing probes for in vitro diagnostics, and target-specific drug delivery. Includes conjugation chemistry for convenient attachment to biomolecules and other targets. For a complete list of available materials, visit

aldrich.com/ionp

Description Amine functionalized nanoparticles Amine functionalized nanoparticles Amine functionalized nanoparticles Biotin functionalized nanoparticles Biotin functionalized nanoparticles Biotin functionalized nanoparticles Carboxylic Acid functionalized nanoparticles Carboxylic Acid functionalized nanoparticles PEG functionalized nanoparticles PEG functionalized nanoparticles PEG functionalized nanoparticles N-succinimidyl ester functionalized nanopowder N-succinimidyl ester functionalized nanopowder N-succinimidyl ester functionalized nanopowder

Concentration

Particle Size (nm)

Prod. No.

1 mg/mL in H2O 1 mg/mL in H2O 1 mg/mL in H2O 1 mg/mL in H2O 1 mg/mL in H2O 1 mg/mL in H2O 5 mg/mL in H2O 5 mg/mL in H2O 1 mg/mL in H2O 1 mg/mL in H2O 1 mg/mL in H2O — — —

5 10 30 5 10 30 10 30 5 10 30 5 10 30

747343 747300 747327 747416 747424 747432 747254 747335 790508 747319 747408 747440 747459 747467

Carbon Nanotubes Used as molecular transporters in drug delivery systems and nearinfrared (NIR) imaging agents. For a complete list of available materials, visit

aldrich.com/cnt Description

Carbon nanotube, single-walled, carboxylic acid functionalized Carbon nanotube, multi-walled, carboxylic acid functionalized Carbon nanotube, single-walled, poly(ethylene glycol) functionalized Carbon nanotube, single-walled, amide functionalized Carbon nanotube, single-walled, octadecylamine functionalized Carbon nanotube, single-walled, polyaminobenzene sulfonic acid functionalized

Bundle Dimensions

Purity (%)

Prod. No.

D 4–5 nm × L 0.5–1.5 μm D 9.5 nm × L 1.5 μm D 4–5 nm × L 0.5–0.6 μm D 4–6 nm × L 0.7–1.0 μm D 2–10 nm × L 0.5–2 μm D 1.1 nm × L 0.5–1.0 μm

>90 >80 >80 >90 80–90 75-85

652490 755125 652474 685380 652482 639230

For more information, visit sigma-aldrich.com

Fluorescent Nanodiamonds Used for diagnostics, photoacoustic imaging, biolabeling, and drug delivery. For a complete list of available materials, visit

aldrich.com/nanobiomed

Description

Concentration

Particle Size (nm)

Prod. No.

1 mg/mL 1 mg/mL 1 mg/mL 1 mg/mL 1 mg/mL

70 100 90 100 120

798169 798142 798150 798134 798088

Emission Maximum (nm)

Absorption Maximum (nm)

Particle Size (nm)

Prod. No.

590 590 590 590

555 555 555 555

25 50 90 120

797928 797936 797898 797863

>300 nitrogen-vacancy center per particle >400 nitrogen-vacancy center per particle >500 nitrogen-vacancy center per particle >800 nitrogen-vacancy center per particle >1,200 nitrogen-vacancy center per particle

Silica Nanobeads Used for flow cytometry, bioimaging, bioisensing, and diagnostics. For a complete list of available materials, visit

aldrich.com/nanobiomed

Description Fluorescent nanobeads Fluorescent nanobeads Fluorescent nanobeads Fluorescent nanobeads

For more information, visit sigma-aldrich.com

POLYMERIC

DRUG DELIVERY

TECHNIQUES

Translating Polymer Science for Drug Delivery A guide to drug delivery solutions using polymers for controlled release, targeted drug delivery and solubility enhancement. yy Step-by-step methods written by drug delivery experts highlighting polymer-based methods to solve the most important drug delivery challenges yy Solutions for: -- Small molecules -- Nucleic acids -- Proteins yy Key technologies: -- Drug conjugation and PEGylation -- Biodegradable nanoparticles and micelles -- RAFT polymeric carriers for ADCs -- Dendrons -- Responsive drug delivery systems -- Polymers for oligonucleotide delivery Request your copy online at

Aldrich.com/ddtechnique

Enabling Science to Improve the Quality of Life

Order/Customer Service: sigma-aldrich.com/order Technical Service: sigma-aldrich.com/techservice Development/Custom Manufacturing Inquiries [email protected] Safety-related Information: sigma-aldrich.com/safetycenter

©2015 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA, SAFC, SIGMA-ALDRICH, ALDRICH and SUPELCO are trademarks of Sigma-Aldrich Co. LLC, registered in the US and other countries. FLUKA is a trademark of Sigma-Aldrich GmbH, registered in the US and other countries. Sigma-Aldrich, Sigma, Aldrich, Supelco, Fluka and SAFC brand products are sold by affiliated Sigma-Aldrich distributors. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see product information on the Sigma-Aldrich website at www.sigmaaldrich.com and/or on the reverse side of the invoice or packing slip.

World Headquarters 3050 Spruce St. St. Louis, MO 63103 (314) 771-5765 sigma-aldrich.com

RQU 83667 1065