Monday 20 July | Sessions MOPL01
MOSY03
Monday Plenary Plenary Session
Venue:
Ballroom C-D
Time:
08:15-10:30
The Strategic Timing of AntiRetroviral Treatment (START) Study: Results and Their Implications Symposia Session
Co-Chairs: Françoise Barré-Sinoussi, Institut Pasteur, France Gregory Taylor, Public Health Agency of Canada, Canada
Venue:
Ballroom A
Time:
11:00-12:30
Co-Chairs: Wafaa El-Sadr, ICAP at Columbia University, Mailman School of Public Health, United States Kenly Sikwese, African Community Advisory Board, Zambia
Women, Girls and HIV Investigator’s Prize presented by Françoise Barré-Sinoussi
This session presents the full results of the START study, a randomised controlled trial of immediate versus deferred ART initiation of 4685 HIV+ participants with untreated HIV-infection and a CD4+ count above 500 cells/µL, that was recently unblinded by the study data-safety-andmonitoring board. Following questions and answers specifically related to these results, a panel discussion with participation of key stakeholders on the wider implications from these results will take place.
F.Barré-Sinoussi, Institut Pasteur, France
HIV Response in 2015: Opportunities and Challenges D.Birx, The U.S. President's Emergency Plan for AIDS Relief (PEPFAR), United States
From Care to Cure N.Chomont, University of Montreal, Canada
Co-morbidities in Children and Adolescents T.Puthanakit, Faculty of Medicine, Chulalongkorn University, Thailand
Introduction
Grant Presentation: Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Grant Programme L.Bekker, Desmond Tutu HIV Foundation, South Africa
Treatment as Prevention versus other Biomedical Prevention: Contrasting Implementation Challenges F.Venter, University of Witswatersrand, South Africa
MOBS03
Bridging Session Room 211-214
Time:
11:00-12:30
MOAB01
Paediatrics: Growing up on ART Oral Abstract Session
The recent discovery and genetic/structural characterization of a large number of novel HIV-1 broadly neutralizing antibodies (NAbs) has led to renewed enthusiasm for their potential use in passive immunization strategies for HIV-1 prevention. The present session, directed to basic and clinical scientists, will provide an introduction to this topic and will highlight key research developments in the field. At the completion of the session, participants will understand the basics of HIV-1 neutralizing antibodies and their application in passive immunization strategies. Participants will also gain an understanding of the mechanisms of HIV-1 transmission/spread (cell-free vs. cell associated) and their consequences for efficiency of HIV-1 blockade by NAbs. Finally, an overview of current and future studies aimed at formulating NAbs as HIV-1 prevention strategies, including an update on the preliminary data from the NIH VRC601 trial, will be provided.
Venue:
Ballroom B
Time:
11:00-12:30
Co-Chairs: Celia Christie-Samuels, The University of the West Indies, Jamaica Jason Brophy, University of Ottawa, Canada Field evaluation of point-of-care testing for early infant diagnosis in Cape Town, South Africa M. Kroon, L. Dunning, M. Hsiao, L. Myer South Africa
High rates of baseline NNRTI-resistance and virologic failure among ART naïve HIV-1-infected children in Mali C.S. Crowell, A.I. Maiga, M. Sylla, B. Taiwo, N. Koné, R.L. Murphy, A.-G. Marcelin, B. Traore, D.B. Fofana, E.G. Chadwick United States
T cell activation and treatment outcomes among infants receiving early ART K.H. Ásbjörnsdóttir, J.A. Slyker, D. Wamalwa, S. De Rosa, J.P. Hughes, A. Rowhani-Rahbar, B.H. Chohan, S. Benki-Nugent, K. Tapia, G.C. John-Stewart United States
Introduction Blocking HIV-1 spread by broadly neutralizing antibodies
Changes in renal laboratory parameters and bone mineral density in treatment-naïve HIV-1-infected adolescents initiating therapy with INSTI-based single-tablet regimens containing tenofovir alafenamide (TAF) or tenofovir disoproxil fumarate (TDF)
O.Schwartz, Pasteur Institute, France
Broadly neutralizing antibodies as topical microbicides D.Anderson, Boston University, United States
Broadly neutralizing antibodies for immunoprophylaxis: update from VRC601 B.Graham, National Institute of Allergy and Infectious Diseases, United States; B.Graham, National Institute of Allergy and Infectious Diseases, United States
Conclusion
Panel discussion: the implications from the START findings
Questions and answers: the science of the study
Co-Chairs: Glenda Gray, South African Medical Research Council, South Africa John Mascola, National Institutes of Health, United States
Questions and answers
J.Lundgren, University of Copenhagen, Denmark; A.Babiker, MRC Clinical Trials Unit -UCL, United Kingdom; F.Gordin, U.S. Department of Veterans Affairs Medical Center, United States; J.Neaton, University of Minnesota School of Public Health, United States
D.Birx, The U.S. President's Emergency Plan for AIDS Relief (PEPFAR), United States; G.Hirnschall, World Health Organization, Switzerland; S.Abdool Karim, Centre for the AIDS Programme of Research in South Africa, South Africa; Z.Wu, Chinese Center for Diseases Control and Prevention, China; K.Thomson, The Global Fund to fight AIDS, Tuberculosis and Malaria, Switzerland
New Approaches to Using Broadly Neutralizing Antibodies for HIV Prevention
Venue:
The START study: design, conduct and main results
H. Kizito, A. Gaur, W. Prasitsuebsai, N. Rakhmanina, K. Chokephaibulkit, J. Fourie, L.-G. Bekker, Y. Shao, S. Bennett, E. Quirk United States
Treatment and resistance outcomes of Asian children on second-line antiretroviral therapy W. Prasitsuebsai, S. Teeraananchai, K.H. Truong, J. Ananworanich, V.C. Do, L.V. Nguyen, P. Kosalaraksa, N. Kurniati, T. Sudjaritruk, K. Chokephaibulkit, T. Singtoroj, S.J. Kerr, A.H. Sohn, TASERPediatrics Study Thailand
www.ias2015.org
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Monday 20 July | Sessions Week 48 safety and efficacy of a rilpivirine (TMC278)-based regimen in HIV-infected treatment-naïve adolescents: PAINT phase II trial J. Lombaard, T. Bunupuradah, P. Flynn, J. Ramapuram, F. Ssali, H. Crauwels, A. Hoogstoel, V. Van Eygen, M. Stevens, K. Boven United States
In utero tenofovir exposure is not associated with fetal long bone growth J. Jao, L. Myer, T. Phillips, G. Petro, A. Zerbe, E.J. Abrams United States
MOAB02
Ballroom C-D 11:00-12:40
P. Frange, A. Faye, V. Avettand-Fenoel, E. Bellaton, D. Deschamps, M. Angin, S. Caillat-Zucman, G. Peytavin, J. Le Chenadec, J. Warszawski, C. Rouzioux, A. Saez-Cirion, ANRS EPF-CO10 Pediatric Cohort France
Co-Chairs: Haileyesus Getahun, World Health Organization, Switzerland Constance Benson, University of California, San Diego, United States
Time associated changes in cell-associated HIV RNA in HIV-infected subjects on suppressive antiretroviral therapy - implications for clinical trials of cure interventions
The durability of isoniazid preventive therapy for tuberculosis: long-term follow-up from a prospective cohort of HIV-infected adults in South Africa C. Hanrahan, N. Martinson, G. Link-Barnes, R. Msandiwa, R. Chaisson, J. Golub United States
C. Chang, P. Cameron, J. Elliott, A. Perelson, M. Roche, A. Dantanarayana, A. Solomon, V. Naranbhai, S. Tenakoon, R. Hoh, J. McMahon, K. Sikaris, W. Hartogensis, P. Bacchetti, F. Hecht, J. Lifson, S. Deeks, S. Lewin Australia
MOWS01
Treatment outcomes of drug-resistant TB patients in South Africa, disaggregated by HIV status, as reported in a national electronic drug-resistant TB register D.H. Evans, K. Schnippel, E. Budgell, K. Shearer, R. Berhanu, L. Long, S. Rosen South Africa
Excess TB mortality in HIV patients in Eastern Europe: restructured approach to care needed A. Schultze, A.M. Werlinrud Efsen, F.A. Post, A. Panteleev, H. Furrer, R. Miller, M.H. Losso, J. Toibaro, A. Skrahin, J.M. Miro, J.A. Caylà, E. Girardi, M. Bruyand, N. Obel, D.N. Podlekareva, J.D. Lundgren, A. Mocroft, O. Kirk, on behalf of the TB:HIV Study Group in EuroCoord United Kingdom
Missed opportunities in the TB/HIV cascade of care in 14 high burden TB/HIV African countries, 2012 A. Baddeley, M. Doherty, A. Kanchar, A. Matteelli, H. Bakir Timimi, H. Getahun WHO
Empiric TB therapy does not decrease early mortality compared to isoniazid preventive therapy in adults with advanced HIV initiating ART: results of ACTG A5274 (REMEMBER study) M. Hosseinipour, G. Bisson, S. Miyahara, X. Sun, A. Moses, C. Riviere, F.K. Kirui, S. Badal-Faesen, D. Lagat, M. Nyirenda, K. Naidoo, J. Hakim, P. Mugyenyi, G. Henostroza, P.D. Leger, J.R. Lama, L. Mohapi, J. Alave, V. Mave, V.G. Veloso, S. Pillay, N. Kumarasamy, J. Bao, E. Hogg, L. Jones, A. Zolopa, J. Kumwenda, A. Gupta, Adult AIDS Clinical Trials Group 5274 (REMEMBER) Study Team Malawi
IAS TB/HIV Research Prize
Implementing and Evaluating HIVrelated Stigma Mitigation Interventions Workshop
Venue:
Room 109
Time:
11:00-12:30
Co-Chairs: Anton Best, Ministry of Health, Barbados Ron MacInnis, Futures Group, United States Laura Nyblade, Health Policy Project, RTI International, United States This workshop is directed to HIV scientists and programme implementers interested in assessing the impact of HIV stigma on their work. It will also be of interest to HIVpositive populations’ representatives and advocates. The session will cover new and innovative approaches being used to mitigate HIV-related stigma and the appropriate outcomes of interest for impact. At the completion of the session, participants will be able to describe current concepts and definitions in HIV- and AIDS-related stigma for prevention and mitigation, critically assess interventions targeting stigma for prevention and mitigation, and select the appropriate methods and approaches for their research or programme. Introduction The HPP stigma and discrimination-reduction package: an overview L.Nyblade, Health Policy Project, RTI International, United States
Stigma reduction and clinical competency building in healthcare settings for men who have sex with men and transgender populations in Barbados
L.Bekker, Desmond Tutu HIV Foundation, South Africa
MOAA01
Trancriptomics and metabolomics identify inflammatory profiles that segregate subjects with high and low inducible HIV reservoir
HIV-1 virological remission for more than 11 years after interruption of early initiated antiretroviral therapy in a perinatally-infected child
Oral Abstract Session
Time:
S. Lee, N. Chomont, R. Fromentin, R. Silicano, J. Silicano, D. Richman, U. O'Doherty, S. Palmer, P. Burbelo, S. Deeks United States
K. Ghneim, J. Ahlers, S. Fourati, C. Shive, M. Cameron, P. Mukerjee, M. Ghannoum, B. Rodriguez, S. Deeks, M. Lederman, R. Sekaly United States
HIV and TB: Gaps and Opportunities
Venue:
Anti-HIV antibody responses reflect the quantifiable HIV reservoir size
A.Best, Ministry of Health, Barbados
Persistently Seeking Virus
Venue:
Room 118-120
Stigma reduction for HIV and key populations aimed at both health and human rights leaders: experiences and approaches in Africa
Time:
11:00-12:30
R.MacInnis, Futures Group, United States
Eli Boritz, National Institute of Allergy and Infectious Diseases, United States Sarah Palmer, Faculty of Medicine, University of Sydney, Australia
Questions and answers
Oral Abstract Session
Conclusion
MOWS02 A murine viral outgrowth assay to detect HIV in patients with undetectable viral loads
How to write and submit a conference abstract Workshop
K. Metcalf Pate, C. Pohlmeyer, V. Walker-Sperling, J. Foote, K. Najarro, C. Cryer, M. Salgado, L. Gama, E. Engle, E. Shirk, S. Queen, S. Chioma, M. Vermillion, B. Bullock, M. Li, C. Lyons, R. Adams, C. Zink, J. Clements, J. Mankowski, J. Blankson United States
Virologic and immunologic correlates of viral control post-ART interruption in SIV-infected rhesus macaques L. Micci, E. Ryan, R. Fromentin, C. Benne, N. Chomont, J. Lifson, M. Paiardini United States
Venue:
Room 121-122
Time:
11:00-12:30
Co-Chairs: Marlene Bras, Journal of the International AIDS Society, Switzerland Mark Wainberg, McGill AIDS Centre, Mc Gill University, Canada Papa Salif Sow, Bill & Melinda Gates Foundation, United States
www.ias2015.org
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Monday 20 July | Sessions Conference attendance is a tremendous opportunity to present research, exchange ideas and discuss with peers. It is an important part of any HIV professionals career, offering invaluable networking and professional development opportunities. Participation in addition to attendance at conferences is mostly on the basis of abstract selection for presentations. However, how to write a conference abstract can be a challenge to less experienced authors. By the end of this workshop, participants will know how to write and submit a wellwritten conference abstract and increase chances of acceptance. The main part of the workshop will cover the practical issues of writing an abstract, focusing on its structure and the contents to be included in each section.Key take-home messages will be highlighted and examples offered to demonstrate good practice as well as common mistakes to avoid.Short exercises will be used to enhance the learning experience. Introduction to learning objectives M.Bras, Journal of the International AIDS Society, Switzerland
Michael Lederman, Case Western Reserve University, United States Within-host evolution of X4 HIV-1 in a rare transmission pair revealed by phylogenetic reconstruction of deep-sequence data A. Le, J. Taylor, W. Dong, R. McCloskey, C. Woods, K. Hayashi, M.J. Milloy, P.R. Harrigan, A.F.Y. Poon, Z.L. Brumme Canada
Genetic ancestry component proportions are correlated with HIV disease progression D. Garrido-Rodriguez, S. Avila-Rios, H. Valenzuela-Ponce, T. García-Tellez, V. Quiroz-Morales, C. García-Morales, M. Soto-Nava, A. Murakami-Ogasawara, J.C. Fernandez-Lopez, G. Reyes Terán Mexico
Dasatinib preserves SAMHD1 antiviral activity in CD4+ T cells treated with IL-7 J. Alcami, M. Bermejo, B. Descours, E. Mateos, M.M. Lederman, M. Benkirane, M. Coiras Spain
M.Bras, Journal of the International AIDS Society, Switzerland
HIV-specific latency reversing therapies that exploit novel pathways for suboptimal Tat protein expression
How to correctly write each abstract section (exercises included)
D. Purcell, J. Jacobson, L. Harty, K. Jarman, K. Lackovic, G. Khoury, T. Mota, M. Lee, G. Bernardi, S. Saleh, S. Sonza, S. Lewin Australia
How to structure your abstract
M.Wainberg, McGill AIDS Centre, Mc Gill University, Canada; M.Bras, Journal of the International AIDS Society, Switzerland
HIV rebound and meningoencephalitis following ART interruption after allogeneic hematopoietic stem cell transplant: an investigation of the source of HIV rebound
How to avoid common pitfalls that result in the rejection of your conference abstract
A. Capoferri, M. Sievers, A. Redd, A. Cash, D. Xu, S.F. Porcella, T. Quinn, R.F. Siliciano, M. Levis, R.F. Ambinder, C.M. Durand United States
P.Sow, Bill & Melinda Gates Foundation, United States
Q&A, evaluation, conclusions
MOSS01
Progress and Challenges in HIV Prevention: Vaccine and Non-Vaccine Approaches
Assay to measure the latent reservoir of replication-competent HIV-1 in suppressed patients based on ultra deep sequencing S.-K. Lee, S. Zhou, N. Archin, D. Margolis, S. Joseph, R. Swanstrom United States
Special Session Venue:
Ballroom A
Time:
13:00-14:00
MOPDC01
HIV Testing: The Gateway for Everything Oral Poster Discussion
Co-Chairs: Chris Beyrer, Bloomberg School of Public Health, Johns Hopkins University, United States Eugenia Socias, Fundacion Huesped, Argentina In this special session, Dr. Anthony S. Fauci discusses recent progress and challenges in the field of HIV prevention. He will outline emerging opportunities within and synergies between vaccine and non-vaccine prevention modalities, and the critical roles each will play in ending HIV transmission. In particular, he will discuss the potential impact of scaling up treatment as prevention and the selective application of pre-exposure prophylaxis (PrEP) in selected at-risk populations. In addition, he will outline the scientific challenges that remain in HIV vaccinology, including the effort to improve upon the modest success of the RV144 trial and the potential to deliver or induce broadly neutralizing antibodies to block HIV transmission. He also will discuss the “implementation gap” between the development of interventions and their delivery to people who need them, and potential solutions (e.g., deploying tailored interventions in high-transmission settings) needed to close that gap. Introduction Progress and challenges in HIV prevention: vaccine and non-vaccine approaches A.Fauci, National Institutes of Health, United States
Moment to honour Dr. Jack Whitescarver, former NIH Associate Director for AIDS Research and Director of the Office of AIDS Research and Chair of Towards an HIV Cure
Venue:
Room 110
Time:
13:00-14:00
Co-Chairs: Jeffrey D. Klausner, University of California Los Angeles, United States Ilesh Jani, National Institute of Health, Mozambique Communities can mobilize to test: findings from a community randomized trial of a theory-based community mobilization (CM) intervention in South Africa S.A. Lippman, A.P. Pettifor, T.B. Neilands, C. MacPhail, D. Peacock, S. Maman, R. Twine, A. Selin, K. Kahn United States
Reducing stigma and increasing HIV testing with a health information intervention, a clusterrandomized trial from Malawi L. Derksen, A. Muula, J. van Oosterhout, M. van Lettow, A. Matengeni, S. Sodhi United Kingdom
HIV self-testing increases HIV testing frequency among high-risk men who have sex with men: a randomized controlled trial D. Katz, M. Golden, J. Hughes, C. Farquhar, J. Stekler United States
Home HIV testing among transgender women in San Francisco: a pilot feasibility and acceptability study S.A. Lippman, M.E. Moran, A. Ventura, L.S. Castillo, S. Buchbinder, S. Treves-Kagan, J.M. Sevelius United States
C.Beyrer, Bloomberg School of Public Health, Johns Hopkins University, United States
Supervised HIV self-testing to inform implementation and scale up of self-testing in Zimbabwe
MOPDA01
S. Napierala Mavedzenge, E. Sibanda, Y. Mavengere, K. Hatzold, O. Mugurungi, G. Ncube, F. Cowan United States
From Pathogenesis to Persistence Oral Poster Discussion
Venue:
Room 109
Time:
13:00-14:00
Co-Chairs: James Whitney, Ragon Institute of MGH, MIT and Harvard, United States
Integrating partner notification services into PMTCT (Option B+) services in the northwest and southwest regions of Cameroon P.T. Muffih, E. Mboh, E. Fang, W. Wainfen, H. Fon, T. Welty, R. Shields, M. Golden Cameroon
www.ias2015.org
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Monday 20 July | Sessions MOPDB01
Women and Children First
Bridging Session
Oral Poster Discussion
Venue:
Ballroom A
Venue:
Room 118-120
Time:
14:30-16:00
Time:
13:00-14:00
Co-Chairs: Valdilea G. Veloso, Evandro Chagas Clinical Research Institute, Brazil Douglas Brooks, Office of National AIDS Policy, United States
Co-Chairs: Annette H. Sohn, TREAT Asia / American Foundation for AIDS Research, Thailand Deborah M. Money, Research BC Women's Hospital + Health Centre Women's Health Research Institute, Canada Bacterial vaginosis, intravaginal practices and HIV genital shedding: implications for HIV transmission M. Alcaide, M. Chisembele, E. Malupande, K. Arheart, D. Jones, M. Fischl United States
IUD use in HIV-positive women L.A. Vicol, A. Hornsberger, N. Pick, J. Van Schalkwyk, D. Bloomenthal, J. Christilaw, D. Money Canada
Effectiveness of contraception for HIV-infected women using antiretroviral therapy: combined data from 3 longitudinal studies M. Pyra, R. Heffron, N.R. Mugo, K. Nanda, K.K. Thomas, C. Celum, A.P. Kourtis, J.M. Baeten, Partners in Prevention HSV/HIV Transmission Study and Partners PrEP Study Teams United States
Importance of programmatic longitudinal surveillance for identification of congenital anomalies among infants exposed to HIV-1 and antiretrovirals: findings from the Mpepu Study, Botswana
Introduction Combination prevention of HIV sexual transmission
G. Ajibola, R. Shapiro, R. Zash, L. Holmes, O. Batlang, K. Ramogothobeng, F. Chilisa, K. Bennett, J. Makhema, S. Lockman, K. Powis Botswana
Moderated discussion
MOPDD01
Time:
13:00-14:00
Combination prevention for MSM A.Grulich, University of New South Wales, Australia
S.Baral, Center for Public Health and Human Rights, Johns Hopkins Bloomberg School of Public Health, United States
Biomedical prevention M.Cohen, University of North Carolina School of Medicine, United States
Oral Poster Discussion Room 121-122
C.Caceres, Cayetano Heredia University, Peru
Combination prevention for sex workers
Implementation Challenges among People Who Inject Drugs
Venue:
Evidence-based prevention means basing the response on local epidemic data and providing prevention services wherever risk is occurring. Combination prevention programmes are designed and delivered at local/community level but enabled and resourced at national and state/provincial levels. Combination prevention promotes the association of biomedical, behavioural, and structural/community interventions in an appropriate mix to reduce HIV incidence. Combinations must focus on the predominant mode of transmission in a locality. Effective combinations can thus be discerned and defined using available evidence but call for a different way of doing business and assessing impact. This session is directed to clinicians involved in the care of people living with HIV, medical care providers, behavioural health professionals, global Ministry of Health and HIV programme managers, implementers, funders, and monitoring and evaluation specialists, and aims to further define the concept and practice of combination prevention, relating this to prevention programmes for sexual transmission and offering new insights, innovations and directions in this field.
Discussion Conclusion
Co-Chairs: Kora DeBeck, Simon Fraser University, Canada Sylvia Adebajo, Population Council, Nigeria
MOBS01
The effect of opiate substitution therapy on healthcare utilization and engagement among HIVinfected people who inject drugs in Ukraine C. Bachireddy, J. Izenberg, M. Soule, S. Dvoryak, F. Altice United States
The effects of opioid substitution treatment and highly active antiretroviral therapy on the causespecific risk of mortality among injection drug using people living with HIV/AIDS B. Nosyk, J.E. Min, E. Evans, L. Li, L. Liu, V. Lima, E. Wood, J. Montaner Canada
Assessing the HIV prevention potential of Mexico´s 'narcomenudeo' drug law reform: implementation challenges among people who inject drugs L. Beletsky, P. Gonzalez-Zuniga, G. Rangel, D. Werb, J. Arredondo, S.A. Strathdee United States
Low threshold services for females who inject drugs: reducing gender inequities in methadone enrollment B.H. Lambdin, C. Nyandindi, D. Bruce, N. Sabuni, A. Magimba, E. Matiko United States
Increasing rates of earlier antiretroviral treatment associated with elevated levels of optimal virologic response among HIV-positive illicit drug users during a treatment-as-prevention-based initiative in a Canadian setting M.-J. Milloy, T. Kerr, R. Hogg, S. Guillemi, J. Montaner, E. Wood Canada
Immune Activation in HIV: Friends or Foe? Bridging Session
Venue:
Room 211-214
Time:
14:30-16:00
Co-Chairs: Peter Reiss, Academic Medical Center, Amsterdam University, Netherlands Michael Lederman, Case Western Reserve University, United States Immune activation/inflammation persists despite suppressive HAART and multiple lines of evidence link persistent immune activation to increased morbidity and mortality in HIV-positive individuals. However, inflammation may play a dual role in modulating the course of infection, with certain types of inflammatory responses – notably type 1 interferon responses – conferring beneficial effects alongside detrimental ones. Directed to scientists and clinicians interested in the latest research on immune activation in HIV, this translational session will summarize our current understanding of the role of inflammation in modulating HIV-1 infection and will discuss whether and how to incorporate inflammatory biomarkers into clinical practice. At the completion of the session, participants will understand the different causes of immune activation in HIV-positive people on cART and its morbid consequences, and will be able to assess different therapeutic approaches with their advantages and disadvantages. Introduction What drives persistent immune activation/inflammation in cART-treated HIV-1? G.Marchetti, University of Milan, San Paolo Hospital, Italy
MOBS02
The Present and Future of Combination Prevention for HIV Sexual Transmission
Immune activation/inflammation as predictors of morbidity and mortality during HAART
www.ias2015.org
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Monday 20 July | Sessions P.Hunt, University of California, San Francisco, School of Medicine, United States
A silver lining in every cloud: the two sides of interferon N.Sandler Utay, University of Texas Medical Branch, United States
Symposia Session Venue:
Room 121-122
Time:
14:30-16:00
Chair:
Julio Montaner, BC Centre for Excellence in HIV/AIDS, University of British Columbia, Canada
Strategies to reduce immune activation/inflammation I.Pandrea, University of Pittsburgh, United States
Moderated discussion: Moving from bench to bedside, should we be enhancing or suppressing immune activation in HIV? Conclusion
MOSY01
How Would You Like Your PrEP? Symposia Session
Venue:
Ballroom C-D
Time:
14:30-16:00
Co-Chairs: Jean-Michel Molina, Saint-Louis Hospital, France Robert M Grant, Gladstone Institutes, United States This session presents latest findings from the HPTN 067 ADAPT trial of non-daily PrEP in Cape Town, Bangkok, and Harlem. The study findings have deep implications for PrEP rollout, related to flexibility in dosing, engagement with PrEP and factors leading to disengagement, forgiveness for missed doses, and how to start and how to stop PrEP, and patterns of sexual activity among women and MSM. Combined with emerging information from pharmacokinetics studies and the Ipergay study, this session provides an outstanding opportunity to discuss the safety, efficacy, and utility of non-daily regimens, and provide a perspective on overall flexibility in PrEP dosing. Directed toward practitioners who are prescribing PrEP, program implementers, advocates and policy makers, the objective of the session is to improve our understanding and practice of PrEP rollout, including how PrEP use can be adapted to different patterns of sexual activity. Introduction
Antiretroviral therapy’s proven ability to prevent deaths, illness and new infections cannot be effectively harnessed without substantially greater success in expanding knowledge of HIV status. As of today, more than 50% of people living with HIV do not know their sero-status. As the world embarks on ending AIDS by 2030, stakeholders have embraced a new target to ensure that by 2020 90% of all people living with HIV will know their HIV status. Achieving this target will require a major reinvention of HIV testing. Maximising HIV testing uptake and ensuring early diagnosis of people living with HIV will require much stronger leadership on HIV testing, strategic combination of acceptable and high yield testing modalities, policy changes to decentralize and democratize HIV testing and fully embracing innovations including HIV self-testing and incidence testing. This session will bring together leading experts in a panel discussion on the programmatic changes and innovations needed to close the testing gap. It will include a debate on HIV self-testing, multidisease campaigns and explore the potentials of incidence testing. Introduction Strategies for testing in the context of treatment expansion B.Samb, UNAIDS, Switzerland
New technologies to advance HIV testing T.Peter, African Society for Laboratory Medicine/Clinton Health Access Initiative, Botswana; T.Peter, African Society for Laboratory Medicine/Clinton Health Access Initiative, Botswana
Enhanced HIV testing in the context of human rights J.Amon, Bloomberg School of Public Health, John Hopkins University, United States
Accelerating HIV testing to reach 90% testing coverage in countries G.Chamie, University of California San Francisco, United States
Updates on PrEP efficacy in Ipergay
Scaling up HIV testing to 90% coverage: cost and financing perspectives
J.Molina, Saint-Louis Hospital, France
HPTN 067 ADAPT methods and results from women in Cape Town R.Grant, Gladstone Institutes, United States
J.Stover, Avenir Health, United States
Questions and Answers Conclusion
HPTN 067 ADAPT results from MSM in Bangkok T.Holtz, Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Thailand
MOAC01
HPTN 067 ADAPT results from MSM in Harlem
Oral Abstract Session
S.Mannheimer, Columbia University, United States
PrEP experiences among South African women in the HPTN067 (ADAPT) study: Healthy paranoia, Ubuntu, champions and challenges to resolving PrEP dissonance R.Amico, University of Michigan School of Public Health, United States
Patterns of Sex and PrEP in Bangkok MSM (HPTN 067) T.Chemnasiri, Thailand MOPH-U.S. CDC Collaboration (TUC), Thailand
Venue:
Ballroom B
Time:
14:30-16:00
Co-Chairs: Nagalingeswaran Kumarasamy, YRGCARE Medical Centre, India Mina Hosseinipour, The University of North Carolina Project-Malawi (UNC Project), Malawi Final results of the HPTN 052 randomized controlled trial: antiretroviral therapy prevents HIV transmission
Patterns of Sex and PrEP in Harlem MSM: A qualitative study (HPTN 067)
M. Cohen, Y. Chen, M. McCauley, T. Gamble, M. Hosseinipour, N. Kumarasamy, J. Hakim, N. Kumwenda, T. Brum, B. Grinsztejn, S. Godbole, S. Chariyalertsak, B. Riegel Santos, K. Mayer, I. Hoffman, S. Eshleman, E. Piwowar-Manning, S.-S. Ou, L. Cottle, J. Makhema, L. Mills, R. Panchia, S. Badal-Faesen, J. Eron, J. Gallant, D. Havlir, S. Swindells, V. Elharrar, D. Burns, T. Taha, K. Nielsen, D. Celentano, M. Essex, T. Fleming, HPTN 052 Study Group United States
J.Franks, ICAP at Columbia University, United States
How to start and stop PrEP: a pharmacology perspective (HPTN 067 and more) D.Glidden, University of California, United States
A PrEP user's perspective
Treatment as prevention: characterization of partner infections in the HIV Prevention Trials Network 052 trial
D.Jacobs, PrEP advocate and licensed therapist, United States
Panel discussion and questions Conclusion
MOSY04
TasP: Just Do It
Democratizing HIV testing to reach the 90-90-90 target
S.H. Eshleman, S.E. Hudelson, S.S. Ou, A.D. Redd, R. Swanstrom, S.F. Porcella, Y.Q. Chen, E. Piwowar-Manning, M. McCauley, T. Gamble, M. Sievers, C.A. Martens, D. Bruno, L.-H. Ping, E. Dukhovlinova, T.C. Quinn, J. Kumwenda, M. Maliwichi, N. Nhando, V. Akelo, S. Moyo, R. Panchia, N. Kumarasamy, N. Chotirosniramit, M.M. Rocha, F. Bustorff, B. Grinsztejn, K.H. Mayer, J.P. Hughes, M.S. Cohen, for the HPTN 052 Study Team
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Monday 20 July | Sessions United States
Level of viral suppression and cascade of HIV care in a South African semi-urban setting in 2012 (ANRS-12126 -12285) K. Jean, A. Puren, E. Cutler, B. Singh, J. Bouscaillou, R. RainTaljaard, D. Taljjard, P. Lissouba, G. Peytavin, B. Auvert France
A mathematical model to determine potential costs and benefits of increasing antiretroviral therapy coverage in female sex workers: the case of Panama L. Jenkins, J. Nordio, K. Vasarhelyi, A. Nunez, R. Barrios, A. Rutherford Canada
Does a universal test and treat strategy impact ART adherence in rural South Africa? ANRS 12249 TasP cluster-randomized trial C. Iwuji, R. Dray-Spira, A. Calmy, J. Larmarange, J. OrneGliemann, F. Dabis, D. Pillay, K. Porter South Africa
Community-based HIV testing and linkage effectively delivers combination HIV prevention: results from a multisite randomized trial
Opening comments
R. Barnabas, H. van Rooyen, E. Tumwesigye, J. Brantley, J. Baeten, A. van Heerden, B. Turyamureeba, P. Joseph, M. Krows, J. Hughes, C. Celum, Linkages United States
MOWS03
High rates of patient recruitment, retention, and adherence to study interventions in HIV trials are essential to ensuring reliable study outcomes. Patient and community education should thus be a key priority for any investigator seeking to conduct a trial, and is particularly essential when involving vulnerable and key affected populations who face additional social and legal barriers to study participation. This workshop is directed to trial researchers and staff as well as community educators interested in engaging key populations in clinical trials. At the completion of the session, participants will understand the requirements for participant- and community-level training regarding the purposes and conduct of HIV research trials. They will increase their appreciation of clinical trial literacy needs and implementation approaches for different vulnerable populations and by geographic setting. In addition, they will be able to recognize and understand reasons for the success or failure of efforts to engage vulnerable populations in trials and propose solutions to address deficiencies in trial preparations.
S.Wakefield, HIV Vaccine Trials Network (HVTN), United States
Clinical trial literacy among men who have sex with men B.Spire, INSERM, France
The Developing World in Our Own Backyard: Concentrated HIV Epidemics in High Income Settings
Experience sharing from Thailand: communitybased test and treat study
Workshop
Clinical trial literacy among young women and girls
Venue:
Room 109
Time:
14:30-17:30
N.Phanuphak, Thai Red Cross AIDS Research Centre, Thailand
S.Abdool Karim, Centre for the AIDS Programme of Research in South Africa, South Africa
Questions and answers There is as burgeoning epidemic in the heart of Canada among the aboriginal communities of Saskatchewan and Manitoba. Despite the recognition of the problem early in 2009, little progress has been made to slow the rate of new infections and deal with the health disparities that fuel the epidemic. Similar but distinct issues are relevant to Eastern Europe and the Southern US. This workshop is targeted to health professionals, public health officials, and affected communities and will highlight the similarities and differences between these local population specific epidemics. It will discuss what the relevant medical, public health and governmental agencies have and have not done to address these issues and to discuss potential unique and common solutions to the problem. Introduction The HIV epidemic in Saskatchewan, Canada: injection drug use, indigenous peoples and human tragedy A.Wong, University of Saskatchewan, Canada
Saskatchewan indigenous strategy on HIV and AIDS: the way forward M.Poitras, All Nations Hope Network, Canada
A large outbreak of HIV infections related to injection drug use, Indiana USA 2014-15 J.Brooks, Centers for Disease Control and Prevention, United States
Migration of an epidemic: HIV in the Southeastern United States K.Schafer, Wake Forest University Health Sciences, United States
The concentrated HIV epidemic in Ukraine: effective strategies, results achieved and emerging challenges
MOSY02
Achieving HIV Remission: Reconciling Disparate Strategies Symposia Session
Venue:
Ballroom B
Time:
16:30-18:00
Co-Chairs: Françoise Barré-Sinoussi, Institut Pasteur, France Sharon Lewin, Doherty Institute, The University of Melbourne, Australia Currently, various strategies for achieving long-term drugfree HIV remission are being explored. Such strategies include, in particular, ‘shock and kill’ approaches - involving the reactivation of latently-infected CD4+ T-cells through the use of chromatin remodeling and/or other small molecules while on suppressive HAART (the “shock”), followed by gene and/or immunomodulatory therapies to eliminate recrudescent virus (the “kill”) as well as a diametrically opposed strategy – that of permanently silencing HIV reservoirs via approaches to maintain HIV latency. This session is directed to scientists and clinicians interested in this issue. It will provide an overview of strategies to achieve sustained HIV remission and debate their relative merits, challenges and feasibility. At the completion of the session, participants will have a broad understanding of strategies currently under investigation, will appreciate the relative merits, limitations and remaining knowledge gaps associated with each approach and will comprehend how they may be combined or used in complement. Introduction
T.Deshko, International HIV/AIDS Alliance in Ukraine, Ukraine
Waking the sleeping giant: 'shock and kill' approaches for latency reactivation
Panel discussion
R.Siliciano, Johns Hopkins University, United States
Conclusion
Silencing the HIV reservoir S.Valente, The Scripps Research Institute, United States
MOWS04
Clinical Trial Literacy among Vulnerable Populations
Gene and immunomodulatory therapies to disable latent HIV K.Jerome, University of Washington, United States
Workshop Venue:
Room 110
Time:
14:30-16:30
Moderated discussion: how can we reconcile/combine therapeutic strategies to achieve sustained HIV remission?
Chair:
Steve Wakefield, HIV Vaccine Trials Network (HVTN), United States
MOSY05 www.ias2015.org
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Monday 20 July | Sessions TRANS-forming Health Care: Challenges and Advancements in the Development and Access to Comprehensive Transgender Healthcare
M. Lallemant, B. Amzal, S. Urien, P. Sripan, T. Cressey, N. NgoGiang-Huong, B. Rawangban, P. Sabsanong, T. Siriwachirachai, T. Jarupanich, P. Kanjanavikai, P. Wanasiri, S. Koetsawang, G. Jourdain, S. Le C?ur, PHPT-5 Study Team Thailand
Symposia Session
Costs of Zimbabwe's accelerated prevention of mother-to-child transmission of HIV program
Venue:
Room 121-122
Time:
16:30-18:00
Chair:
JoAnne Keatley, Center of Excellence for Transgender Health, United States
I. Ochoa-Moreno, C. Mangenah, R. Buzdugan, N.S. Padian, S.I. Mccoy, F.M. Cowan, S. Bautista-Arredondo Zimbabwe
MOAD01
Through an interactive discussion among international, regional and national stakeholders, this session is aimed at highlighting best practice in addressing comprehensive transgender healthcare – including HIV. Current advancements, resources and challenges will be shared as “building blocks” for the development of a roadmap to ensure access in a variety of settings.
90-90-90: Delivering on the Targets Oral Abstract Session
Venue:
Ballroom C-D
Time:
16:30-18:00
Co-Chairs: Mitchell Warren, AVAC, United States Deenan Pillay, Africa Centre, South Africa
Transform What? J.Keatley, Center of Excellence for Transgender Health, United States
Main gaps and challenges in LAC and suggestions to address them with a case example of La Clinica Condesa, Mexico E.Román-Mar, Clínica Condesa, Mexico
Main gaps and challenges in Brazil and suggestions to address them with good practice examples R.Weist, , Brazil
Main gaps and challenges for transgender men and suggestions to address them with good practice examples A.Scheim, Ontario Gay Men's Sexual Health Alliance, Canada
PrEP for Trans woman: what are the opportunities and challanges J.Keatley, Center of Excellence for Transgender Health, United States
Rapid uptake and adoption of the WHO 2013 Consolidated ARV guideline recommendations: paving the way to achieving the 90/90/90 global target M. Doherty, M. Beusenberg, E. Asamoah-Odei, F. Lule, R. Pendse, M. Ghidinelli, Y.-R. Lo, G. Reidner, M. Donoghoe, M. Vitoria, G. Hirnschall WHO
Can the UNAIDS 90-90-90 target be achieved? Analysis of 12 national level HIV treatment cascades J. Levi, A. Raymond, A. Pozniak, P. Vernazza, P. Kohler, A. Hill United Kingdom
Major outcomes of early HAART programs at CCASAnet sites: “First Wave of HAART” study M. Wolff, C.P. Cortes, B.E. Shepherd, M. Giganti, C. Mc Gowan, Caribbean, Central America and South America Network (CCASAnet) Chile
Integrating HIV-care into primary care clinics improved access to treatment and did not compromise primary health care: province-wide trend analysis over four years during implementation in Free State, South Africa
Updates from international organisations A.Verster, World Health Organization, Switzerland
Open discussion
A. Rawat, K.E. Uebel, D. Moore, A. Yassi Canada
Closing remarks J.Keatley, Center of Excellence for Transgender Health, United States
Implementation scale up of the Adherence Club model of care to 30,000 stable antiretroviral therapy patients in the Cape Metro: 2011-2014
MOAC02
PMTCT: Gaps and Next Steps
L. Wilkinson, B. Harley, S. Jacobs, C. Cragg, E. Kriel, S. Solomon, N. Peton, K. Jennings, M. Youngleson, A. Grimsrud South Africa
Oral Abstract Session
Moderated discussion
Venue:
Ballroom A
K.Kunisaki, Minneapolis VA Health Care System, United States
Time:
16:30-18:00 MOAA02
Co-Chairs: Lynne Mofenson, National Institute of Child Health and Human Development, National Institutes of Health, United States Newton Kumwenda, Johns Hopkins Research Project, Malawi
Microbiome: the Good and the Bad for HIV Oral Abstract Session
Post prevention of mother-to-child-transmission: 30-months outcomes in the Malawian “Option B+ programme” A.D. Haas, L. Tenthani, M.T. Msukwa, A. Jahn, D. Midiani, E. Mhango, O. Gadabu, K. Tal, A. Spörri, M. Egger, F. Chimbwandira, J.J. van Oosterhout, O. Keiser Switzerland
Recruiting male partners for couple HIV counseling and testing in Malawi's Option B+ program: a randomized controlled trial
Venue:
Room 211-214
Time:
16:30-18:00
Co-Chairs: Leonid Margolis, National Institute of Child Health and Human Development, National Institutes of Health, United States Ivona Pandrea, University of Pittsburgh, United States Introduction J.Brenchley, National Institute of Allergy and Infectious Diseases, United States
N. Rosenberg, T. Mtande, F. Saidi, C. Stanley, E. Jere, L. Mwangomba, K. Kumwenda, I. Mofolo, M. Mwale, A. Chauma, W.C. Miller, I. Hoffman, M.C. Hosseinipour Malawi
Treatment with anti-a4ß7 integrin antibody reduces virus-mediated gastrointestinal pathology by targeting distinct mucosal tissues
Zimbabwe approaching virtual elimination of mother to child transmission of HIV following implementation of Option A
S. Byrareddy, J. Arthos, C. Cicala, K. Reimann, T. Parslow, P. Santangelo, F. Villinger, A. Fauci, A. Ansari United States
R. Buzdugan, S.I. McCoy, C. Watadzaushe, M.-S. Kang Dufour, M. Petersen, J. Dirawo, A. Mushavi, H.A. Mujuru, A. Mahomva, B. Engelsmann, A. Hakobyan, O. Mugurungi, F.M. Cowan, N.S. Padian United Kingdom
Antiretroviral intensification to prevent intrapartum HIV transmission in late comers
Oral microbiome in HIV-infected women: aging, disease progression and opportunistic infections increase the pathogenic profile M. George, B. Weiser, H. Burger, T. Lewy, K. Anastos United States
Serum-derived bovine immunoglobulin isolate increases peripheral and mucosal CD4 T cell count in patients with HIV enteropathy
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Monday 20 July | Sessions D. Asmuth, M. Somsouk, P. Hunt, Z.M. Ma, C. Miller, X.D. Li, J. Hinkle, A. Shaw, E. Weaver, G. Klein United States
HIV-exposure, gut microbiome, and vaccine responses in South African infants K. Viljoen, J. Wendoh, U. Karaoz, E. Brodie, N. Mulder, G. Botha, E. Kidzeru, J. Butcher, C. Gray, K. Rosenthal, A. Abimiku, B. Cameron, A. Stintzi, H. Jaspan South Africa
SIV-induced translocation of bacterial products in the liver mobilizes myeloid dendritic and natural killer cells associated with liver damage J. Schafer, T. Evans, H. Li, R.K. Reeves United States
MOAC03
Late Breakers: HIV prevention interventions and missed opportunities for prevention Oral Abstract Session
Venue:
Room 118-120
Time:
16:30-18:00
Co-Chairs: Jean-Michel Molina, Saint-Louis Hospital, France Steffanie A Strathdee, University of California San Diego, Department of Medicine, United States Increasing uptake of voluntary medical male circumcision (VMMC) among men aged 20-34 years in Njombe & Tabora regions, Tanzania: a cluster randomised controlled trial M. Wambura, R. Hayes, J. Grund, S. Kapiga, H. Mahler, G. Mshana, E. Kuringe, M. Plotkin, N. Bock, N. Larke, J. Changalucha, H. Weiss, VMMC Tanzania Study Group Tanzania, United Republic of
Acceptability and feasibility of a novel approach to promote HIV testing in sexual and social networks using HIV self-tests H. Thirumurthy, I. Akello, K. Murray, S. Masters, S. Maman, E. Omanga, K. Agot United States
HPTN 067/ADAPT study: a comparison of daily and intermittent pre-exposure prophylaxis (PrEP) dosing for HIV prevention in men who have sex with men and transgender women in New York city S. Mannheimer, Y. Hirsch-Moverman, A. Loquere, J. Franks, J. Hughes, S.-S. Ou, K.R. Amico, C. Hendrix, B.J. Dye, E. PiwowarManning, M. Marzinke, V. Elharrar, M. Stirratt, R.M. Grant, HPTN 067/ADAPT Harlem Study Team United States
HPTN 067/ADAPT study: a comparison of daily and non-daily pre-exposure prophylaxis dosing in Thai men who have sex with men, Bangkok, Thailand T.H. Holtz, A. Chitwarakorn, M.E. Curlin, J. Hughes, K.R. Amico, C. Hendrix, B.J. Dye, P.L. Anderson, S.-S. Ou, V. Elharrar, S.H. Eshleman, M. Stirratt, R.M. Grant, Bangkok HPTN 067/ADAPT Study Team Thailand
Community outbreak of HIV infection linked to injection drug use of oxymorphone - Indiana, 2015 J. Duwve, K. Hoover, C. Conrad, R. Galang, D. Hillman, B. Hoots, M. Patel, P. Peters, P. Pontones, J. Roseberry, J. Shields, D. Waterhouse, P. Weidle, J. Brooks United States
HIV-1 and HCV molecular epidemiology of a large community outbreak of HIV-1 infection linked to injection drug use of oxymorphone - Indiana, 2015 R.R. Galang, J. Gentry, P.J. Peters, S.J. Blosser, E.L. Chapman, C. Conrad, J.M. Duwve, L. Ganova-Raeva, W. Heneine, D. Hillman, H. Jia, L. Liu, W. Luo, J. Lovchik, S. Masciotra, S.M. Owen, A. Perez, P. Peyrani, P. Pontones, S. Ramachandran, J.C. Roseberry, M. Sandoval, A. Shankar, H. Thai, G. Xia, Y. Khudyakov, W.M. Switzer, J. Brooks United States
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