Plot # 6-3-347/9 | D No: 204 | Riviera Buildings | Behind Model House, Dwarakapuri Colony | Punjagutta | Hyderabad - 500 082 Tel: 040-2335 0551 | Email:
[email protected] | www.genesnlife.com
CANCER GENETIC TESTS Dear Doctor, We are please to produce largest array of Oncogene-DX (Molecular Diagnostic Tests) for Cancers.
MOLECULAR GENETIC TESTS Mutation Tests Test Code G1S001
Test Name
Disease
Method
Sample Type
TAT
BRAF Mutation Analysis
Papillary Thyroid (45%)
PCR & SEQ
ST: FFPE or Tumor Tissue or FNA HC: 5 ml Blood or 3 ml Bone marrow
5-7 Days
Colorectal (40-50%) NSCLC (15-25%)
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
[V600E]
Melanoma (60-80%) Hairy Cell Leukemia (100%) Colorectal (5-22%) Serous Ovarian (26%) Non-small cell lung cancer (NSCLC) (1-3%)
G1S002
KRAS Mutation Analysis [Exon 2 - Codons 12 and 13]
G1S003
BRAF and KRAS Mutation Analysis Panel
Tumors resistant to EGFR inhibitors
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
G1S004
EGFR Mutation Analysis
NSCLC (35-50% in Asians) Colorectal (12%) Esophageal (11%)
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
PCR & SEQ
5ml Blood or 3ml Bone marrow in EDTA Vacutainer (Purple Cap)
5-7 Days
[V617F]
Polycythemia vera (65-97%) Essential thrombocythemia (23-57%)Myelofibrosis (35-57%)
AKT1 Mutation Analysis
Breast (4%) Colorectal (1-6%) NSCLC (1%)
PCR & SEQ
5ml Blood or 3ml Bone marrow in EDTA Vacutainer (Purple Cap)
5-7 Days
[Exon 18, 19, 20, & 21]
G1S005
G1S006
JAK2 Mutation Analysis
[E17K]
G1S007
IDH1 & IDH2 HotSpot Mutation Analysis
Gliomas (70-76%) Acute myeloid leukemia (6-23%)
PCR & SEQ
ST: FFPE or Tumor Tissue or FNA HC: 5 ml Blood or 3 ml Bone marrow
5-7 Days
G1S008
PIK3CA Mutation Analysis
Breast (18-40%) Colorectal (13-32%) Gastric (Stomach) (7-25%) Brain (27%) Lung (1-3%) Ovarian (9%)
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
Gastrointestinal stromal tumors (7082%)
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
[Exon 9 and 20]
G1S009
KIT Mutation Analysis [Exon 9 and 11]
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Plot # 6-3-347/9 | D No: 204 | Riviera Buildings | Behind Model House, Dwarakapuri Colony | Punjagutta | Hyderabad - 500 082 Tel: 040-2335 0551 | Email:
[email protected] | www.genesnlife.com
CANCER GENETIC TESTS G1S010
PDGFRA Mutation Analysis
Gastrointestinal stromal tumors (5%)
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
[D842V]
G1S011
KIT and PDGFRA Mutation Panel
Gastrointestinal stromal tumors
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
G1S012
PTEN Target Mutation Analysis
Breast Cancer (7%)
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
MEN2A and MEN2B (90%)
PCR & SEQ
FFPE or Tumor Tissue or FNA. 5ml Blood for family screening
5-7 Days
Parathyroid tumors, pancreatic tumors, and pituitary tumors
PCR & SEQ
FFPE or Tumor Tissue or FNA. 5ml Blood for family screening
14 Days
Pheochromocytomas (PHEOs) and paragangliomas (PGLs) (25%)
PCR & SEQ
FFPE or Tumor Tissue or FNA. 5ml Blood for family screening
14 Days
[R159S, R233, K267]
G1S013
Medullary Thyroid Carcinoma Mutation Test [RET- Exon 11 & 16]
G1S014
MEN1 Screening Test [Entire coding exons screening]
G1S015
SDHB and SDHD Screening Test (Paragangliomas & Pheochromocytomas)
G1S016
RET, SDHB and SDHD Genes Panel Test
Pheochromocytomas (PHEOs) and paragangliomas (PGLs)(25%)
PCR & SEQ
FFPE or Tumor Tissue or FNA. 5ml Blood for family screening
14 Days
G1S017
NPM1 Mutation Analysis
Acute myeloid leukemia (25-35%)
PCR & SEQ
5ml Blood or 3ml Bone marrow in EDTA Vacutainer (Purple Cap)
5-7 Days
Acute myeloid leukemia (15%)
PCR & SEQ
5ml Blood or 3ml Bone marrow in EDTA Vac
5-7 Days
PCR & SEQ
5ml Blood or 3ml Bone marrow in EDTA Vac
5-7 Days
[Exon 12]
G1S018
FLT3 Mutation Analysis [ITD & D835]
G1S019
G1S020
NPM1 and FLT3 Mutation Panel
Acute myeloid leukemia
GNAS Mutation Analysis
Multiple tumors (adrenocortical, pituitary, pancreatic, renal, large intestine and testis)
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
Screening for risk of developing Breast cancer or Ovarian Cancer
PCR & SEQ
FFPE or Tumor Tissue or FNA. 5ml Blood for family screen
30 days
Predict response to EGFR-targeted immunotherapy in patients with metastatic colorectal cancer
PCR & SEQ
FFPE or Tumor Tissue or FNA
5-7 Days
[Exon 8 & 9]
G1S021
BRCA1 & BRCA2 Mutation Analysis [Sequencing of Coding Exons]
G1S022
(Purple Cap)
Colorectal Cancer Mutation Panel
(KRAS, PIK3CA, BRAF, NRAS)
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(Purple Cap)
Plot # 6-3-347/9 | D No: 204 | Riviera Buildings | Behind Model House, Dwarakapuri Colony | Punjagutta | Hyderabad - 500 082 Tel: 040-2335 0551 | Email:
[email protected] | www.genesnlife.com
CANCER GENETIC TESTS G1S023
Lung Cancer Mutation Panel (EGFR, KRAS, ALK)
Prognostic and therapeutic consequences in non-small cell lung cancer (NSCLC)
PCR, SEQ & FISH
FFPE or Tumor Tissue or FNA
5-7 Days
G1S024
Familial Colorectal Cancer (MSI, APC, MYH)
Familial Colorectal Cancer, Familial Adenomatous Polyps
PCR, SEQ & FISH
FFPE or Tumor Tissue or FNA
5-7 Days
G1S025
Thyroid Cancer Panel (BRAF, RAS, RET/PTC & PAX8/PPARg
Thyroid cancer
PCR, SEQ & FISH
FFPE or Tumor Tissue or FNA
5-10 Days
G1R026
PML-RARA t(15;17) Qualitative
Acute Myeloid Leukemia
G1R027
PML-RARA t(15;17) Quantitative
G1R028
PCR
5 ml Blood or 3 ml Bone marrow
5 Days
Acute Myeloid Leukemia Monitor treatment response Monitor minimal residual disease
RT-PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
AML1-ETO t(8;21) Qualitative
Acute Promyelocytic Leukemia
PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R029
AML1-ETO t(8;21) Quantitative
Acute Promyelocytic Leukemia Monitor treatment response Monitor minimal residual disease
RT-PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R030
CBFB-MYH11 inv(16) Qualitative
AML with abnormal eosinophils
PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1RO31
CBFB-MYH11 inv(16) Quantitative
RT-PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R032
AML Panel Quantitative
RT-PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R033
BCR-ABL t(9:22) Qualitative
Chronic Myelogenous Leukemia (CML), B-lymphoblastic leukemia (B-ALL) diagnosis
PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R034
BCR-ABL t(9:22) Quantitative
Chronic Myelogenous Leukemia (CML), B-lymphoblastic leukemia (B-ALL) diagnosis and monitoring of residual disease
RT-PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R035
E2A-PBX1 t(1;19) Qualitative
Minimal residual disease (MRD) diagnosis of ALL
PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R036
E2A-PBX1 t(1;19) Quantitative
Minimal residual disease (MRD) diagnosis of ALL
RT-PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R037
MLL-AF4 t(4;11) Qualitative
MRD, detection and prognostic indicator for ALL
PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R038
MLL-AF4 t(4;11) Quantitative
MRD, detection and prognostic indicator for ALL
RT-PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R039
TEL-AML1 t(12;21)
MRD, detection and prognostic indicator for ALL
PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
AML with abnormal eosinophils Monitor effectiveness of treatment Monitor minimal residual disease Acute Myeloid Leukemia Monitor treatment response Monitor minimal residual disease
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Plot # 6-3-347/9 | D No: 204 | Riviera Buildings | Behind Model House, Dwarakapuri Colony | Punjagutta | Hyderabad - 500 082 Tel: 040-2335 0551 | Email:
[email protected] | www.genesnlife.com
CANCER GENETIC TESTS Qualitative
G1R040
TEL-AML1 t(12;21) Quantitative
MRD, detection and prognostic indicator for ALL
RT-PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G1R041
ALL Panel
MRD, diagnosis and prognostic indicator for ALL
RT-PCR
5 ml Blood or 3 ml Bone marrow in EDTA
5 Days
G3S003
SPINK1 Mutation Analysis
Chronic Pancreatitis
PCR & SEQ
5ml Blood EDTA Vacutainer (Purple cap)
5-7 Days
G3S004
Chronic Pancreatitis Mutation Panel-1 (SPINK1 & PRSS1) Chronic Pancreatitis Mutation Panel-2 (SPINK1, PRSS1, CFTR, CTSB & CTRC)
Chronic Pancreatitis
PCR & SEQ
5ml Blood EDTA Vacutainer (Purple cap)
5-7 Days
Chronic Pancreatitis
PCR & SEQ
5ml Blood EDTA Vacutainer (Purple cap)
5-7 Days
[N34S]
G3S004
MOLECULAR CYTOGENETIC TESTS Test Code
Test Name
Disease
Method
Sample Type
TAT
GF012
BCR-ABL Translocation (9;22)
CML, AML or Ph-positive ALL
FISH
8ml Blood or 3ml Bone marrow in Heparin Vac (Green Cap)
5 Days
GF013
PML-RARA Translocation (15;17)
Acute promyelocytic leukemia (APL)
FISH
8ml Blood or 3ml Bone marrow in Heparin Vac (Green Cap)
5 Days
GF014
AML-ETO Translocation (8;21)
AML (5-12%), predominantly in younger patients.
FISH
8ml Blood or 3ml Bone marrow in Heparin Vac
5 Days
(Green Cap)
GF015
IGH-MYC Translocation (8;14)
Burkitt lymphoma from other lymphomas
FISH
ST: FFPE or Tumor Tissue or FNA HC: 5 ml Blood or 3 ml Bone marrow
5 Days
GF016
IGH-CCND1 Translocation (11;14)
Non-Hodgkin lymphoma, multiple myeloma.
FISH
ST: FFPE or Tumor Tissue or FNA HC: 5 ml Blood or 3 ml Bone marrow
5 Days
GF017
FISH for X/Y (Post BMT)
As a follow up after bone marrow transplantations
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5 Days
GF018
MLL Break apart 11q23
Acute Lymphoblastic Leukemia & Acute Myelogenous Leukemia
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5 Days
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Plot # 6-3-347/9 | D No: 204 | Riviera Buildings | Behind Model House, Dwarakapuri Colony | Punjagutta | Hyderabad - 500 082 Tel: 040-2335 0551 | Email:
[email protected] | www.genesnlife.com
CANCER GENETIC TESTS GF019
7q22/7q36 Probe
Myelodysplastic Syndromes & AML
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5 Days
GF020
P53 Probe – 17p13 Amplification
Chronic Lymphocytic Leukemia
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5 Days
GF021
DLEU / TP53 – 13q14/17p13
Chronic Lymphocytic Leukemia & Multiple Myeloma
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5 Days
GF022
MYC Dual Color Break point - 8q24
B-Cell Malignancies
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5 Days
GF023
TEL/AML1 t(12:21)
Acute Lymphoblastic Leukemia
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5 Days
GF024
Her2-Nu Amplification
Breast Cancer
FISH
Fresh Tumor tissue or FFPE 5 ml Blood EDTA
5 Days
(Purple Cap)
GF025
Multiple Myeloma 4 Probe Panel
Multiple Myeloma
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5-6 Days
GF026
BCR/ABL + TEL/AML1 + MLL Panel
Acute Lymphoblastic Leukemia Panel
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5-6 Days
GF027
BCR/ABL + TEL/AML1 or MLL [2 Probes]
FISH
5 ml Blood or 3 ml Bone marrow Heparin Vac (Green Cap)
5-6 Days
Terms: Sample Shipment: Specimen are to be transported as per the collection and transport procedures applicable with respect to the test ordered. For sample pick-up, kindly intimate us before 1:00 for sample pick-up Conditions of Reporting: 1. The reported results are for the information of the referring doctor only 2. The test results relate to only to the item/items tested 3. The Result(s) of test(s) requested will be reported within 5 working days upon the receipt of the sample Ordering of Test The sample to be tested shall contain the following information: Page 5
Plot # 6-3-347/9 | D No: 204 | Riviera Buildings | Behind Model House, Dwarakapuri Colony | Punjagutta | Hyderabad - 500 082 Tel: 040-2335 0551 | Email:
[email protected] | www.genesnlife.com
CANCER GENETIC TESTS 1. 2. 3. 4. 5.
Name & reference no of the Test Method of test Reference no of the sample Type of the sample When is the sample collected
Payment 1. Payment to be made 100 % along with the sample For Genes N Life Healthcare Pvt. Ltd. Date: 5th November 2013
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