Michael Sean PEPPER, Curriculum Vitae __________________________________________________________________________________

Professional address Room 5-64, Level 5, Pathology Building 5 Bophelo Road (Cnr. Steve Biko and Dr. Savage Streets) Prinshof Campus University of Pretoria Gezina 0002 Pretoria South Africa Tel: +27 (0)12 319 2179 (Secretary) Tel: +27 (0)12 319 2190 (Direct) Fax: +27 (0)12 319 2946 E-mail: [email protected]

EDUCATION Privat Docent (Habilitation) University of Geneva, Faculty of Medicine, 1997 M.D. University of Geneva, Faculty of Medicine, 1992 Ph.D. University of Geneva, Faculty of Science, 1990 M.B.Ch.B. University of Cape Town Medical School, 1982

REGISTRATION Health Professionals Council of South Africa (HPCSA) registration no.: MP 0261858 Board of Health Funders practice no.: 0140000207756 The South African Medical Association. Member no.: 30227

PROFESSIONAL APPOINTMENTS Current December 2011-present Professor, Department of Immunology, Faculty of Health Sciences, University of Pretoria December 2011-present Director, Institute for Cellular and Molecular Medicine, University of Pretoria January 2006-present Professeur Associé, Department of Human Genetics and Development, Faculty of Medicine, University of Geneva

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Previous August 2008-November 2011 Professor, Unit for Advanced Studies, University of Pretoria January 2005-November 2011 Extraordinary Professor, Department of Immunology, Faculty of Health Sciences, University of Pretoria January 2007-July 2009 Scientific Director, Netcells Cryogenics (Pty) Ltd January 2005-July 2008 Managing Director, Netcare Institute of Cellular and Molecular Medicine (Pty) Ltd, Unitas Hospital, Lyttelton, Pretoria July-December 2004 Professor: Department of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand January-June 2004 Associate Professor (part-time): Department of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand June 2003-June 2004 Associate Professor: Department of Morphology, Faculty of Medicine, University of Geneva Oct 1993-May 2003 Maître d'enseignement et de recherche (Assistant Professor, with tenure): Department of Morphology, Faculty of Medicine, University of Geneva Jan 1991-Sept 1993 Maître-assistant: Department of Morphology, Faculty of Medicine, University of Geneva April 1986-Dec 1990 Assistant and Ph.D. student: Department of Morphology, Faculty of Medicine, University of Geneva 1984-March 1986 Department of Clinical Science and Immunology, Faculty of Medicine, University of Cape Town 1984: Post-intern research scholarship; 1985/6: Registrar 1983 Intern: Groote Schuur Hospital, Cape Town

AWARDS AND OTHER RECOGNITION Exceptional Academic Achiever Award, University of Pretoria, 2015-2017. Selected for inclusion in the book “Blazing a Biotechnology Trail – Celebrating Biotechnology Excellence in South Africa”. Produced by Public Understanding of Biotechnology (NRF/SAASTA), 2014 South African MRC Extramural Unit Award: Stem Cell Research and Therapy. 2015-2020. South African MRC University Flagship Award: Stem Cell Research and Therapy, 2014-2017. Appointed to the Academy of Science of South Africa, 2013.

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Finalist, NSTF-BHP Billiton Awards 2013/2014 in the category: Communication for outreach and creating awareness of Science, Engineering, Technology and Innovation. Finalist, NSTF-BHP Billiton Awards 2012/2013 in the category: Science Communication for Public Awareness over the last 5 years. Sponsored by: The South African Agency for Science and Technology Advancement (SAASTA-NRF). P. Mabeta and M.S. Pepper: Best overall publication, non-clinical. Faculty of Health Sciences, University of Pretoria, 2009. P. Mabeta and M.S. Pepper: Best overall publication, non-clinical. Faculty of Health Sciences, University of Pretoria, 2011(2012). “Prix Denber-Pinard” for Privat Docent thesis. University of Geneva, 1997. Walter J. Johnson Annual Award for post-doctoral research in cell biology. Molecular biology and biochemistry of endothelial cell proteases and their inhibitors. Awarded by Academic Press/Experimental Cell Research, 1994. “Prix de la Faculté de Médecine” for M.D. thesis in basic medical sciences. University of Geneva, 1992. South African Medical Research Council Post-Intern Research Scholarship. University of Cape Town, 1984.

SOCIETIES/ASSOCIATIONS South African Tissue Bank Association (Co-founder; 2012-present) Human Genome Organization (2010-present) South African Genetics Society (2010-present) Southern African Society of Human Genetics (2009-present) World Marrow Donor Association – individual member (2009-present) South African Medico-Legal Society (2009-present) South African Stem Cell Transplantation Society (2008-present) BioSA (Biotechnology SMME Association of South Africa) (Co-founder; 2007-present; President: 2008) Licensing Executives Society (2008-2011) South African Society for Obesity and Metabolism (2006-2008; Member of the EXCOM) European Vascular Biology Association. (1993-2004; Treasurer: 1996-2004)

COMMITTEES / WORKING GROUPS / SCIENTIFIC BOARD National Bio-economy Strategy (Department of Science and Technology) Health Innovation Strategy implementation panel, 2014-present Core Planning Group, 2010-2011 Biobank South Africa Working Group – 2014-present (Co-chair with Prof Ames Dhai) Member of the Advisory Committee of the African Center for Gene Technologies – 2010-present Co-responsible (with Prof Michele Ramsay) for the Southern African Human Genome Programme – 2009present Core Committee, Revision of Chapter 8 of the National Health Act and Human Tissue Regulations (National Department of Health) – 2009-present National Public Umbilical Cord Blood Stem Cell Bank Feasibility Study (National Department of Health and South African National Blood Service) – 2009-present National Advisory Council on Innovation – 2012-2014 (Project leader: Bioeconomy policies and strategies) National Biotechnology Advisory Committee to the Minister of Science and Technology (2006-2012) Chairperson: May-September 2012; Deputy Chair: July 2010-April 2012; Acting Chairperson: October 2009-June 2010

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Regional Gauteng Province Biotech Awards, Adjudication Committee – 2009 University of Pretoria Faculty of Health Sciences Research Committee of the School of Medicine. 2013-present. Research Forum Committee. Chairperson. 2012-present Research Committee of the Faculty of Health Sciences. 2012-present Comprehensive Physical Rehabilitation Research Centre. Advisory Board. 2008 Faculty Research Plan. Committee member. 2006 University of Geneva Medical School Scientific board, Institut des sciences du mouvement et de la médecine du sport. 2003 Committee for the evaluation of PhD students salaries. 2003 MD-PhD program. Committee member. 1995-2003 Committee for problem-based teaching program, 2nd and 3rd year medical students. 1999-2002 Committee for the evaluation of teaching. 1996-1997; 2002 Working group: DNA microarrays. 1999 Working group: integration of basic and clinical sciences. 1997 Network Healthcare Holdings (Netcare) Research Committee. 2005-2008 Bursary Committee. 2007

BIOTECH/PHARMACEUTICAL CONSULTANT ACTIVITY Consultant Merck KGaA, Darmstadt, Germany. 2003-2005. Ampath, Pretoria, South Africa. 2004 Modex Therapeutics, Lausanne, Switzerland. 2000-2002. Transgène SA, Strasbourg, France. 1999-2000. Ad hoc consultant activity Defined Health, Milburn (NJ, USA) Merck KGaA, Darmstadt (Germany) Novo Nordisk A/S, Maalov (Denmark) Serono International SA, Geneva (Switzerland) LifeScan Inc., Johannesburg (South Africa)

TRAINING COURSES ATTENDED Southern African Human Genome Programme: Understanding and Characterizing Southern African Genomes. Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg. 28-31 July 2014 IP Rights from Publicly Funded Research and Developmnent, Center for IP Law, University of Pretoria and Adams and Adams (Pretoria, South Africa). 30 September 2011. Empowering genomics in southern Africa workshop – Application to infectious diseases.University of Limpopo (Polokwane, South Africa). 30 May – 1 June 2011. Essential IP Management Short Course. DNAbiotec (Pty) Ltd. The Innovation Hub (Pretoria, South Africa). 1213 November 2009. Introductory Licensing Workshop. Licensing Executives Society. Lynnwood Conference Center (Pretoria, South Africa). 26 November 2008.

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Good clinical practice. Wits Health Consortium. (Johannesburg, South Africa). 22 May 2007. Maximizing Performance. (Johannesburg, South Africa). 2007 EXCO Finance for Non-financila Managers. Netcare Education. (Pretoria, South Africa). 2006. Course organizer: Mr. Graeme Jay. Swiss 2D PAGE Training Course, Geneva University Hospital (Geneva, Switzerland), 25-29 September 2000. Course organizer: Dr. J.-C. Sanchez. Cours Romand de Formation à l‟Expérimentation Animale, Centre Hospitalier Universitaire Vaudois (Lausanne, Switzerland), 1-5 May 2000. Course organizers: Dr. I. Bolon, Dr. E. Rouiller, Dr. M. Gyger, Dr. T. Pedrazzini. Immunocytochemistry for Light Microscopy, Royal Postgraduate Medical School, Hammersmith Hospital (London, U.K.), 14-18 January 1985. Course organizer: Dr. J.M. Polak. Elective in Orthopaedic Surgery, Toronto Western Hospital (Toronto, Canada), 7 November - 18 December 1981. Host: Dr. R.W. Jackson. Sponsorship: the Journal of Bone and Joint Surgery.

LECTURE SERIES / WORKSHOPS / SYMPOSIUMS ORGANISED Southern African Human Genome Programme (SAHGP) Ethical, Legal and Social Issues (ELSI) workshop Co-organizer, Prof Himla Soodyall Casa Toscana, Pretoria 19 November 2014 MRC University Flagship Award: Stem cell research and therapy University of Pretoria 01 September 2014 Plastic, reconstructive and aesthetic surgery: at the interface between basic and clinical sciences Intervarsity symposium: University of Pretoria, University of the Witwatersrand, MEDUNSA, University of Geneva, Switzerland University of Pretoria 23 June 2014 Swiss-South African Joint Research Program (SSAJRP), Inter-group meeting Biel/Bienne, Switzerland 18 & 19 June 2014 BASAN/UP Inaugural Clean Room Forum University of Pretoria 10 October 2013 Genomics research on indigenous populations: exploring the concept of genomic sovereignty with the San community of southern Africa Kalahari Lodge, Kimberley 10-12 September, 2013 “The Science of Our Times” lecture series Atterbury Theatre, Pretoria 06 August 2013: Stem cells: the hype and the hope 29 October 2013: The human genome 04 February 2014: Sex determination and gender identity

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South African Tissue Bank Association (SATiBA) Cascades Guesthouse, Brooklyn, Pretoria: 29 November 2012 SATiBA launch - Blu Raddison, Sandton: 4 May 2012 Research Forum Committee meetings, Faculty of Health Sciences, University of Pretoria, South Africa Postgraduate student forum: 09 November 2012 28 August 2012 Postgraduate supervisor‟s forum: 15 November 2012 27 August 2012 SAASTA/PUB Critical Thinker‟s Forum The Southern African Human Genome Programme, Baxter Theatre, Cape Town, South Africa. 24 November, 2011 Stem Cells, St George‟s Hotel & Convention Center, Doornkloof, South Africa. 07 November, 2012 Institute for Cellular and Molecular Medicine Day The Innovation Hub, Pretoria, South Africa 02 November, 2012 Certificate in Bioentrepreneurship (Continuing Education at the University of Pretoria) 21-25 October, 2013 – Pretoria, South Africa 08-12 October, 2012 – Cape Town, South Africa 17-21 September, 2012 – Pretoria, South Africa 16-20 July, 2012 – Durban, South Africa 11-15 June, 2012 – Grahamstown, South Africa 19-23 September, 2011 – Cape Town, South Africa 22-26 August 2011 – Pretoria, South Africa 18-22 October, 2010 – Pretoria, South Africa 28 September-3 October, 2009 – Pretoria, South Africa Medical Malpractice Litigation Seminar Institute for Cellular and Molecular Medicine, University of Pretoria, South Africa. 28 September, 2012 25 August, 2012 Legal aspects relating to the applications of biotechnology College of Law, Unisa, Pretoria, South Africa Co-organizer with Prof. Melodie Slabbert 21 August 2012 Neuroscience Day University of Pretoria, Pretoria, South Africa 10 May 2012 19 May 2011 26 May 2010 Emerging Stem Cell Technologies. Dissecting the complex scientific, ethical and legal landscape Institute for Cellular and Molecular Medicine, University of Pretoria Cricklewood Manor, Pretoria, South Africa 29 September, 2011 Engineering an HIV-resistant Immune System CSIR Conference Center, Pretoria, South Africa

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Travel grants from the Swiss-South African Joint Research Program for Profs. Karl-Heinz Krause and Roberto Speck - CHF 3 000 (~R 20 000) 10-11 February, 2011 Southern African Human Genome Program Co-organizer with Prof. Michele Ramsay Irene Lodge, Irene, South Africa 27-28 January, 2011 Stem Cell Transplantation Indaba Co-organizer with Drs. Campbell Macfarlane and Carola Nielser Waterfront, Cape Town, South Africa 02-03 August, 2010 Technology Transfer in South Africa Organized in collaboration with the World Bank Institute and SARIMA Cape Town, South Africa 27 November, 2009 The Human Tissue Regulatory Environment The Innovatiopn Hub, Pretoria 27 May, 2009 GoGlobal: Finland. BioSA-COFISA workshops on global opportunities for the South African biotech sector BioSa visit to Finland: 13-15 February 2008 Definitive workshops in SA: 31 March – 03 April 2008 Preliminary workshops in SA: 21-27 February 2008 Bioethics Forum on Stem Cell Banking. Pretoria, South Africa Co-organizer with Adv. Donrich Jordaan 15 June 2007 7th Annual European Conference of Scientists and Plastic surgeons. Geneva, Switzerland Local Scientific Committee 19-20 September, 2003 New Therapeutic Targets in Vascular Biology. Geneva, Switzerland Co-organizer 06-09 February, 2003 International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies Geneva, Switzerland. Organizing committee/Faculty member 8th meeting, 31 January – 02 February, 2002 7th meeting, 25-27 January, 2001 6th meeting, 27-29 January, 2000 5th meeting, 31 January – 02 February, 1999 Co-organizer of the "Journée d'interaction des groupes de recherche des Facultés de médecine de Lausanne et Genève, Changins, Switzerland 4th meeting, 19 October 2000 3rd meeting, 07 October, 1999 2nd meeting, 08 October, 1998 1st meeting, 16 October, 1997 XIth International Vascular Biology Meeting. Geneva, Switzerland Scientific Committee 06-10 September, 2000

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Molecular and Cellular Biology of Plasminogen Activation. Les Diablerets, Switzerland Local organizing Committee 04-09 September 1999 Symposium entitled "Positive and negative regulation of angiogenesis: from cell biology to the clinic" at the 29ème Assemblée annuelle de l'Union des Sociétés Suisses de Biologie Expérimentale. Geneva, Switzerland 21 March, 1997 Workshop entitled "Angiogenesis: mechanistic insights and disease" at the 30th Annual Meeting of the European Society for Clinical Investigation. Interlaken, Switzerland Co-organiser with E. Battegay, Basel, Switzerland 25 April, 1996

EXPERT WITNESS Nel and Nel vs. Steyn, Burger, Springs Private Hospital Group (Pty) Ltd, Zambakides and Stepien. South Gauteng High Court, Johannesburg (Republic of South Africa). Case no. 2004/15546 and 06/17316. 19-23 August, 2010.

CLINICAL WORK

CLINICAL TRAINING Jan – Dec 1983 Intern: Groote Schuur Hospital, Cape Town General Medicine (4 months), General Surgery (4 months), Emergency Medicine (2 months), Orthopaedic Surgery (2 months) Jan 1985 – March 1986 Registrar: Groote Schuur Hospital, Cape Town Department of Clinical Science and Immunology

CLINICAL ACTIVITY Consultant, Gender Reassignment Cinic, Dept Obstetrics and Gynaecology, Steve Biko Academic Hospital. 2013-present. Permanent consultant, Multidisciplinary consultation for hemangiomas and vascular malformations. Geneva University Hospital. 1994-2004. Ad hoc consultant, Departments/Divisions of Pediatrics, Dermatology, Surgery (Pediatric, Neuro, Plastic), Radiology and Oncology, Geneva University Hospital. 1990-2004.

REVIEWER ACTIVITIES

RESEARCH GRANT COMMITTEES Medical Research Council (South Africa)

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Research Grants Committee of the Medical Research Council. 2012-2014 National Research Foundation (South Africa) Human Capacity and Infrastructure Development (HICD) Panel Meeting: Thuthuka applications for 2014 funding and Thuthuka and IRDP annual progress reports. 18 October 2013 Capacity and strategic platforms grants – Health Sciences panel: Thuthuka applications for 2013 funding and Thuthuka and IRDP annual progress reports. 15 November 2012 Capacity and Strategic Platforms Grants (CSPG) Panel: Sabbatical Programme 2013 Funding. 20 March 2013

EDITORIAL BOARDS & EDITORSHIPS Current Lymphatic Research and Biology. Editorial Board. 2002-present Current Angiogenesis. 2011-present The Journal of Medical Law and Ethics. International Editorial Board. 2012-present Applied and Translational Genomics. 2012-present Previous Associate Editor/Editorial Board. Arteriosclerosis, Thrombosis & Vascular Biology. 1995-2007 Editorial Advisory Board. The Angiogenesis Journal. 1997-2007 Current Cardiology Reviews. 2005-2009 The Open General and Internal Medicine Journal. 2007-2010 Editor of Ampath Molecular and Metabolic Medicine Update newsletter 2005: 3 editions 2006: 6 editions 2007: 6 editions 2008: 6 editions 2009: 4 editions

GUEST EDITOR Applied and Translational Genomics. Special edition on “Pharmacogenomics and Personalized Medicine”. 2012-2013.

ONSITE REVIEWER ACTIVITIES / PANELS CSIR Biosciences Review Panel, CSIR, Pretoria. 9-11 July, 2014. Panel member. International Centre for Genetic Engineering and Biotechnology (ICGEB) site visit for the 5 year review of Prof. Iqbal Parker. Cape Town, South Africa. August 14 2012. Panel member. MRC-NHLS-Wits Human Genomic Diversity and Disease Research Unit (Prof. Himla Soodyall). Johannesburg, South Africa. 27 September 2010. Panel member. MRC-UCT Human Genetics Research Unit (Prof. Raj Ramesar). Cape Town, South Africa. 22 September 2009. Panel member.

AD HOC REVIEWING Articles submitted to journals

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AIDS Patient Care and STDs, American Journal of Pathology, American Journal of Physiology, Angiogenesis Journal, Applied and Translational Genomics, Arteriosclerosis Thrombosis and Vascular Biology, Biochemical and Biophysical Research Communications, Blood, British Journal of Pharmacology, Cancer Cell, Cancer Journal, Cancer Research, Cell, Cell and Tissue Research, Circulation, Circulation Research, Comparative and International Law Journal of Southern Africa, Current Cardiology Reviews, Current Medicinal Chemistry, Dermatology, Developing World Bioethics, Development, Developmental Biology, EMBO Journal, European Journal of Clinical Investigation, Experimental Cell Research, Experimental Hematology, Expert Opinion On Biological Therapy, FAESB Journal, FEBS Letters, Frontiers in Medicine Gastroenterology, Gene Therapy, International Journal of Cancer, Journal of Cell Biology, Journal of Cell Science, Journal of Cellular Physiology, Journal of Clinical Investigation, Journal of Clinical Pathology, Journal of Histochemistry and Cytochemistry, Journal of Investigative Dermatology, Journal of the National Cancer Institute, Journal of Neurosurgery, Laboratory Investigation, Lung Cancer, Microcirculation, Microvascular Research, Molecular and Cellular Biology, Molecular Biology of the Cell, Nature, Nature Medicine, Oncogene, Opthalmologie, PLoS ONE, Proceedings of The National Academy of Sciences USA, Public Health Nutrition, Science, South African Journal of Psychiatry, Stem Cell Reviews and Reports, The Lancet, Thrombosis and Haemostasis, Tydskrif vir Hedendaagse Romeins-Hollandse Reg (Journal of Contemporary South African Roman-Dutch Law).

Research funding applications Association for International Cancer Research, Biotechnology and Biological Sciences Research Council (UK), CANSA, Christie Hospital NHS Trust, Dutch Cancer Society, European Commission, Fondation Carlos et Elise de Reuter, French Ministry of Research and Education, German-Israel Foundation for Scientific Research & Development, Josef Steiner Stiftung, March of Dimes, Katholieke Universiteit Leuven, Medical Research Council (South Africa), National Science Foundation (USA), NATO Collaborative Research Grants, National Research Foundation (South Africa), Natural Sciences and Engineering Research Council of Canada, Netherlands Organization for Scientific Research, Research Council of the University of Leuven, Swiss Cancer League, Swiss National Science Foundation, The Israel Science Foundation, The Wellcome Trust, United States-Israel Binational Science Foundation, Volkswagen Stiftung.

Candidates for academic positions and prizes Deutsche Forschungsgemeinschaft; Imperial Cancer Research Fund; Max-Planck-Gesellschaft; South African Research Chair Initiative; Swiss National Science Foundation; University of Bern; University of Cape Town; University of Fribourg; University of California (Los Angeles); University of the Witwatersrand; The Wellcome Trust.

Other Business plans for several entities National Research Foundation (South Africa) – scientist rating.

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TEACHING

UNDERGRADUATE Faculty of Health Sciences, University of Pretoria Angiogenesis and lymphangiogenesis; 2nd year medical students - 1 hour (2007, 2009-present) Cell-based therapy; 2nd year medical students - 1 hour (2006-present) Pharmacogenetics; 5th year medical students - 1 hour (2009, 2011-present) Bioentrepreneurship; 2nd year BSc students studying Medical Sciences or Physiology - 1 hour (2010) Pharmacogenetics; 2nd year medical students - 1 hour (2005) University of Geneva Medical School Problem-based learning curriculum (1995-2004, 2006-present) Second year medical students - Tutor, “Heart and circulation” module (12-32 hours) (2001-2004, 2006-present) - Tutor, “Cell growth and ageing” module (32 hours) (1995-1999) - Tutor, integration module 1 (4 hours) (1997) - Monitor, practical histology course, “Heart and circulation” module (4 hours) (1996-2004/7) - Monitor, practical histopathology course, “Heart and circulation” module (4 hours) (1999, 2003/4/6/9/10/14) - Monitor, practical anatomical pathology course, “Heart and circulation” module (8 hours) (2003 (responsible), 2006, 2008-2013) Third year medical students - Co-responsible, “Locomotion” module (1999-2002) - Tutor, “Locomotion” module (32 hours) (1998-2003) - Lecture, integration module 2: Mécanismes de l'hypertrophie du myocarde et de l'insuffisance cardiaque (2003-2004) - Monitor, practical histology course, “Locomotion”module (4 hours) (1999-2003) - Monitor, practical histology course, “Defense & Immunity” module (4 hours) (2001-2004) - Examiner, pratical histology, module on “Locomotion” (2000-2004) - Examiner, pratical histology, module on “Defense & Immunity” (2001-2004) Histology practical course, 1st and 2nd year medical students (1987-2004) Histology lectures to paramedical students: blood cells, hematopoiesis, lymphoid system and blood and lymphatic vessels (4 hours) (1993-2003) Lectures on the physiopathology of vascular diseases, 2nd year physiotherapists (4 hours) (2003) Histology/cell biology lectures to second year medical students: Skeletal, cardiac and smooth muscle (8 hours) (1994-1997) Faculty of Health Sciences, University of the Witwatersrand Medical Cell Biology III (ANAT 314) - applied cell biology: 24 hours (2004) Morphological (Gross) anatomy - MBChB II and BSc Biomedical Sciences II students (ANAT 224) (2004) Histology lectures - MBChB II and BSc Biomedical Sciences II students (ANAT 224): bone and cartilage, lymphoid organs (2 hours) (2004) University of Cape Town Medical School Immunology practical course, medical students (1985/6)

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POSTGRADUATE University of Pretoria Early Career Academics Workshop, Department of Research Innovation and Support - Supervision. 2013 Post-graduate workshops at the Faculty of Health Sciences - Academic writing course for basic sciences: scientific writing, structure of a scientific article, journal selection. 2011, 2012 Post-graduate seminars at the Faculty of Health Sciences - Department of Medical Microbiology: The lymphatic vascular tree – the often forgotten second vascular system. 2013 - Research Forum Committee - Postgraduate student forum: Bedside to bench - defining the market in health biotechnology in South Africa. 2012 - Department of Paediatrics (Steve Biko Academic Hospital): Monogenic disorders. 2012. - Department of Obstetrics and Gynaecology (Steve Biko Academic Hospital): Legislation pertaining to cell-based therapy in South Africa: selected aspects. 2012. - Department of Immunology: Mapping the human genome: the dawning of a new era in healthcare. 2010 - Department of Paediatrics (Kalafong Hospital): Overview of stem cell principles and legislation. 2010 - Department of Paediatrics (Steve Biko Academic Hospital): Neonatal hypoxic ischaemic encephalopathy: pathophysiology and litigation. 2010 - Department of Immunology: Cell-based therapy. 2009 - Netcare Jaccaranda Hospital: Cell-based therapy in South Africa. 2007 - Department of Chemical Pathology: Pharmacogenetics: from genotype to phenotype. 2007 - Faculty Research Day: Cell-based therapy. 2006 - Department of Pharmacology: Pharmacogenetics. 2005 - Department of Pharmacology: Angiogenesis. 2005 - Department of Physiology: Hemangiomas and vascular malformations: new insights into their pathogenesis and treatment. 2004 Post-graduate seminars at the Faculty of Natural and Agricultural Sciences - Centre for Microbial Ecology & Genomics: Stem cells - the hype and the hope. 2014 - Department of Genetics: Cell-based therapy. 2008 - Department of Genetics: Pharmacogenetics: from genotype to phenotype. 2007 University of the Witwatersrand Post-graduate seminars at the Faculty of Health Sciences - School of Anatomical Sciences: The Netcare Institute of Cellular and Molecular Medicine. 2007 - Department of Molecular Medicine and Hematology: The lymphatic vascular system: a renaissance. 2004 - School of Anatomical Sciences: Transplantation of islets of Langerhans: beyond transplantation. 2004 - School of Anatomical Sciences: Vascular malformations and hemangiomas: new insights into their pathogenesis. 2004 - School of Anatomical Sciences: The lymphatic vascular system: a renaissance. 2003 Post-graduate seminars at the Johannesburg General Hospital - Department of Medicine: Vascular malformations and hemangiomas: new insights into their pathogenesis. 2004 - Department of Chemical Pathology: Lymphangiogenesis and tumor metastasis. 2003 - Department of Endocrinology: The pathogenesis of myocardial hypertrophy. 2003 University of Geneva

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Post-graduate seminars at the Geneva University Medical Center and Hospital - Department of Genetics and Development. Genes lead the way: the promise of new technology. 2004 - Vascular biology seminar series: Vascular malformations and hemangiomas: new insights into their pathogenesis and treatment. 2004 - Department of Cellular Physiology and Metabolism: VEGF: a novel therapeutic for diabetes? 2004 - Dermatology clinic: Le système vasculaire lymphatique: une renaissance. 2004 - Division of Cardiology: Physiopathologie de l‟hypertrophie du myocarde. 2003 - Division of Oncology: Lymphangiogenèse et métastases tumorales. 2003 - Cours de microimagerie: Laser capture microdissection. 2003 - Vascular biology seminar series: Lymphatic vascular system. 2003 - Department of Surgery: Le système vasculaire lymphatique: une renaissance. 2002 - Department of Geriatrics: Le système vasculaire lymphatique: une renaissance. 2002 - Department of Neurosurgery: Angiogenèse. 2001 - Division of Oncology: Lymphangiogenèse et métastases tumorales. 2001 - Division of Medical Genetics: Angiogenèse et morphogenèse vasculaire. 2000 - Plastic and Reconstructive Surgery Unit: Physiopathologie des hémangiomes et malformations vasculaires. 2000 - Department of Medicine: Angiogenèse: où en est-on? 1999 - Department of Surgery: Angiogenèse: de la biologie cellulaire aux applications cliniques. 1999 - Division of Radio-oncology: Angiogenèse. 1998 - Division of Angiology & Hemostasis: Pathogénie des malformations vasculaires: rôle des facteurs de croissance. 1997 - Department of Medicine: Néo-angiogenèse. 1997 - Endocrinology seminar series: Régulation positive et négative de l'angiogenèse. 1996 - Pediatric clinic: Lésions vasculaires pédiatriques. 1995 - IIIe Cycle Romand en sciences biologiques. Angiogenèse et Cancer. 1994 - Division of Angiology & Hemostasis: Angiogenèse et pathologie vasculaire. 1994 - Dermatology clinic: Angiogenèse et la peau. 1994 - Department of Pharmacology: Angiogenèse in vitro. 1991 - Division of Oncology: Néo-angiogenèse. 1991 Conferences du C.M.U. University Medical Center, Geneva - Le système vasculaire lymphatique: une renaissance. 2002 - Régulation positive et negative de l'angiogenèse: de la biologie cellulaire aux applications cliniques. 1995 Histology for post-graduate students, Department of Morphology. Blood cells and hematopoiesis; blood and lymphatic vessels; cartilage and bone (6 hours). 2002-2004 Ph.D. students‟ program on molecular and cellular biology (9 hours). 2000-2004 Ph.D. students‟ course on the biology of connective tissues (4 hours). 1992-1994 University of Lausanne and Ecole Polytechnique Fédérale de Lausanne Post-graduate seminars at the Lausanne University Hospital - Institute of Pathology: Lymphangiogenesis and tumor metastasis. 2002 - Division of Surgical Research: Manipulating angiogenesis: from basic science to the bedside. 1997 - Department of neurosurgery: Angiogenesis: a balance between positive and negative regulators. 1996 Post-graduate seminars at the Ecole Polytechnique Fédérale de Lausanne - Department of Rural Engineering: Angiogenèse et assemblage de la paroi vasculaire. 1998

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University of Cape Town Faculty of Medicine - B.Sc. (honours) immunology course: Lymphocyte ontogeny and differentiation. 1985/6

STUDENTS PRE-GRADUATE STUDENTS -

Thandeka Msimang (Medical student, University of Pretoria) 1 month elective, 2007 Sophie Excoffier (Medical student, University of Geneva) 2 month training period, 2003 Thomas Agoritsas (Medical student, University of Geneva) 2 month training period, 2001 Patrick Myers (Medical student, University of Geneva) 2 month training period, 1999 Gérald Hentsch (Medical student, University of Lausanne) 3 month training period, 1998

POST-GRADUATE STUDENTS Diploma students Faculty of Science, University of Geneva - Hélène Mottaz (Department of Morphology) Oct 2002 - March 2004 - Marie Zbinden (Department of Morphology) Oct 2002 - March 2004 Honours students Faculty of Health Sciences, University of Pretoria - Carla Dessels (Department of Anatomy) 2011 - Jacobus Rademan (Department of Pharmacology) 2010 - Tyren Dodgen (Department of Pharmacology) 2007 - Eloise Fraenkel (Department of Anatomy) 2007 - Johannie du Plessis (Department of Pharmacology) 2006 - Monique du Preez (Department of Pharmacology) 2006 - Warren Hochfeld (Department of Pharmacology) 2006 Faculty of Natural and Agricultural Sciences, University of Pretoria - Antoinette Colic (Department of Biochemistry) 2014 MSc students Faculty of Health Sciences, University of Pretoria - Chantel Gouveia (Department of Immunology) 2015-present - Janis von Johannides (Department of Immunology) 2015-present - Carla Dessels (Department of Immunology) 2013-present - Danielle de Villiers (Department of Immunology) 2012-present - Jeanne van Rensberg (Department of Immunology) 2012-present - Fiona van Vollenstee (Department of Immunology) 2010-present - Juanita Mellet (Department of Immunology). Dissertation entitled: Factors determining the composition of a public cord blood stem cell bank including HLA diversity. MSc obtained in September 2013 - Karlien Kallmeyer (Department of Immunology). Dissertation entitled: Isolation and characterization of mesenchymal stem cells from human tissues. MSc obtained in September 2013 - Fatima Barmania (Department of Immunology) Dissertation entitled: Analysis of CCR5 diversity in the South African population. MSc obtained in April 2012 - Monique du Preez (Department of Immunology) Dissertation entitled: Implementation of a blood conservation program in a private hospital setting in South Africa. MSc obtained in April 2012 - Doretha Thompson (Department of Immunology) Dissertation entitled: Flow cytometric analysis of stem cells derived from umbilical cord blood. MSc obtained in April 2010 - Murray Logan (Department of Immunology). Dissertation entitled: Investigation of MC4 Receptor Polymorphisms and the Effect of Bariatric Surgery on a Selected Group of South African Obese Patients. MSc obtained in September 2009

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PhD students Faculty of Health Sciences, University of Pretoria - Nicolette du Plessis (Department of Paediatrics) 2015-present - Mqondisi Tshabalala (Department of Immunology) 2014-present - Elize Wolmarans (Department of Immunology) 2014-present - Karlien Kallmeyer (Department of Immunology) 2014-present - Juanita Mellet (Department of Immunology) 2013-present - Carlo Jackson (Department of Immunology) 2010-present - Tyren Dodgen (Department of Pharmacology). Thesis entitled: Pharmacogenetics of CYP2D6 and CYP2C19 as a pre-prescription tool for drug efficacy and toxicity in a demographically-representative sample of the South African population. PhD obtained in September 2013 - Madeleine Meissner-Roloff (Department of Immunology). Thesis entitled: The effect of HIV on the formation of colony forming units in vitro & public willingness to donate to a public cord blood bank. PhD obtained in April 2013 - Peaceful Mabeta (Department of Physiology). Thesis entitled: The effect of bleomycin, mitomycin C, and cytoskeletal-disrupting drugs on angiogenesis in vitro and haemangioma development in vivo. PhD obtained in December 2008 Faculty of Medicine, University of Geneva - Riccardo Nisato (Department of Cell Physiology and Metabolism). Thesis eititled: Role of integrins, metalloproteinases and VEGFRs in angiogenesis in vitro and in lymphangiogenesis in vitro and in vivo. PhD obtained in September 2005 - Jean-Christoph Tille, MD (Department of Morphology). Thesis entitled: Le rôle des récepteurs à VEGF dans la régulation de l‟angiogenèse. PhD obtained in October 2003 - Stefano Mandriota (Department of Morphology). Thesis entitled: Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin family members. PhD obtained in September 1999 MD student Geneva University Hospital, Switzerland - Pierre Quinodoz (Plastic and Reconstructive Surgery) Thesis entitled: Amélioration de la survie des lambeaux cutanés: une nouvelle technique utilisant des cellules encapsulées transfectées avec bFGF. MD obtained in 1999 Post-doctoral students Department of Immunology, University of Pretoria - Ahmed Oloyo (Department of Immunology, University of Pretoria) 2014-present - Melvin Ambele (Department of Immunology, University of Pretoria) 2014-present - Shanthi Sharon Kappala (Department of Immunology, University of Pretoria) 2013-present - Cheryl Stewart (Department of Immunology, University of Pretoria) 2012-present - Marco Alessandrini (Department of Immunology, University of Pretoria) 2011-present - Christa Durandt (Department of Immunology, University of Pretoria) 2006-2007; 2012-2013 - Marnie Potgieter (Department of Immunology, University of Pretoria) 2010-2013 - Heidi Fickl (Department of Immunology, University of Pretoria) 2008-2009 Department of Morphology/Cell Physiology and Metabolism, Geneva University Medical Center - Jillian Harrison (Serono Pharmaceutical Research Institute, Geneva, Switzerland). 2003-2004 - Raphaële Buser (Serono Pharmaceutical Research Institute, Geneva, Switzerland). 2002-2004 - Kai-Uwe Schlaudraff (Plastic & Reconstructive Surgery, Geneva University Hospital). 2000-2002 - Lin Cui (Institute of Molecular Cell Biology, University of Singaopre). 2000-2002 - Navid Alizadeh (Plastic and Reconstructive Surgery, Geneva University Hospital). 1998-2000 - Ghamartaj Hosseini (Obstetrics and Gynecology, Geneva University Hospital). 1997-2000 - Lee Gorden (University of Minnesota, Minneapolis, MN, USA). 1994-1996 - Ginetta Collo (Scripps Research Institute, La Jolla, CA, USA). 1995 - Nicola Maggiano (University of Rome, Italy). 1986-1987 Thesis co-supervisor Doctoral students - Nicolaas Pool (D. Tech Biomedical Technology, Tshwane University of Technology) 2014-present

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-

Johan Viljoen (Department of Electrical, Electronic and Computer Engineering, University of Pretoria) 2014-present - Belinda Bunn (Dept of Oral Pathology, University of Pretoria) 2014-present - Joji Theron (Department of Physiology, University of Pretoria) 2012-present - Renier Myburgh (Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich) 2009-present - Dominik Lévigne (Department of Plastic and Reconstructive Surgery, University of Geneva). Thesis entitled: More than a nutrient: the role of oxygen in the pathophysiology and therapy of chronic wounds in ischemic and hyperglycemic conditions. PhD obtained in October 2014 MSc students - Karel de Bruin (Department of Electrical, Electronic and Computer Engineering, University of Pretoria) 2014-present - Melanie Skeen (Department of Physiotherapy, University of Pretoria) 2009-present MMed students - Keshree Gayaparsad (Institute of Pathology, University of Pretoria). Thesis entitled: An immunohistopathological review of vascular malformations and other vascular lesions using novel lymphatic specific endothelial markers Podoplanin and D2-40. MMed (Anatomical Pathology) obtained in 2007 LLM students - Safia Mahomed (Department of Jurisprudence, Unisa). Thesis entitled: A legal framework for the regulation of stem cell research and therapy in South Africa. LLM obtained in 2013 Honours students - Janis von Johannides (Dept of Pharmacology, University of Pretoria) 2014 - Karel de Bruin (Department of Electrical, Electronic and Computer Engineering, University of Pretoria) 2013 - Kristen Klose (Graduate School of Technology Management, University of Pretoria). Thesis entitled: Understanding Technology Transfer at Higher Education Institutes (HEIs): A South African Study. Degree obtained in 2010 Prizes awarded to post-graduate students Dr. Pierre Quinodoz Swiss Society for Plastic Reconstructive and Aesthetic Surgery. Title of presentation: Amélioration de la survie des lambeaux cutanés: une nouvelle technique utilisant des cellules encapsulées transfectées. 1999. Dr. Navid Alizadeh Swiss Society for Plastic Reconstructive and Aesthetic Surgery. Title of presentation: Active-site inactivated FVIIa (FVIIai) increases survival in a random skin falp model of acute ischemia. 2001. Dr Jean-Christophe Tille Prix Arditi de la Faculté de Médecine de Genève. For PhD thesis entitled “Le rôle des récepteurs à VEGF dans la régulation de l‟angiogenèse”. 2005. Dr. Ajay Mahajan Progressive tissue injury in burns is reduced by rNAPc2. Prize for the best paper at the British Burns Association (BBA) meeting. York, UK, April 2005. Peace Mabeta 1. South African Women in Science Award, Gender responsive research. Finalist (second place). 2005. 2. Microscopy Society of Southern Africa, Innovative Research. 1st position. 2006. 3. Junior researcher of the year, 3rd Place. Faculty of Health Sciences, University of Pretoria, 2007. 4. Best publication, basic sciences category. Faculty of Health Sciences, University of Pretoria. 2010. 5. Best overall publication, non-clinical. Faculty of Health Sciences, University of Pretoria. 2012. Tyren Dodgen 1. Best oral presentation, 2nd place. Utilization of the Roche Amplichip platform for pre-prescription genotyping. South African Genetics Society (SAGS) Congress, Pretoria, 2008.

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2. Best junior researcher, 2nd place. Phenotyping of CYP450-mediated drug metabolism in a demographically representative sample of the South African population. Faculty Day, University of Pretoria, 2008. 3. Young Scientist Award, 2nd place. Drug metabolite phenotyping of CYP2D6 and CYP2C19 enzyme activity in a demographically representative sample of the South African population. South African Society for Basic and Clinical Pharmacology congress, Rhodes University, 2008. 4. Best junior researcher, 1st place. Pre-prescription genotyping of CYP2D6 and CYP2C19 in a demographically representative group of the South African population. Faculty Day, University of Pretoria, 2009. 5. Young Scientist Award, 2nd place. Genotype vs. phenotype and the allelic variation of CYP2D6 and CYP2C19 in a demographic sample of the South African population. International Congress on Pharmaceutical and Pharmacological Science, University of the North West.2009. 6. Best PhD oral presentation, 2nd place. Is the Roche AmpliChip CYP450 Test the correct pharmacogenetic screening assay for CYP2D6 and CYP2C19 in the South African population? South African Genetics Society (SAGS) Congress, Bloemfontein. 2010. 7. Best junior researcher, 3rd place. Pharmacogenetics of CYP2C19 for personalising medication in the South African population. Faculty Day, University of Pretoria, 2010. Dr. Marnie Potgieter 1. Junior researcher, basic science, 3rd prize: Human mesenchymal stem cells: isolation, characterization and differentiation (M Potgieter, F van Vollenstee, K Kallmeyer, C Jackson, C Dessels, MS Pepper), Faculty Day, University of Pretoria, 31 August 2011. 2. Junior researcher, basic science, 3rd prize: The effect of light activation on mesenchymal stem cell phenotype (M Potgieter, C Durandt, D de Villiers, MS Pepper), Faculty Day, University of Pretoria, 29 August 2012. Fiona van Vollenstee 1. Basic sciences posters, 2nd prize (joint award): Evaluation of the PROCLEIX ULTRIO Plus assay for the detection of HIV-1 in the umbilical cord- and adipose tissue derived mesenchymal stem cells (F Van Vollenstee, L Gaggia, D Hoffman, K Kallmeyer, M Potgieter, P Coetzee, M Vermeulen, MS Pepper). Faculty Day, University of Pretoria, 20-21 August 2013. Karel de Bruyn 1. Students posters, 3rd prize (joint award): A theoretical probabilistic approach to mesenchymal stem cell proliferation modelling (K De Bruin, M Potgieter, P de Villiers, MS Pepper). Faculty Day, University of Pretoria, 20-21 August 2013. Melanie Skeen 1. Best platform presentation, 3rd prize: A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury (M Skeen, C Eksteen, MS Pepper). 52nd International Spinal Cord Society Annual Scientific Meeting, Istanbul, Turkey, 28-30 October 2013. Karlien Kalmeyer 1. Basic sciences posters, 1st prize: Differences in Basic Biological Characteristics Exist Between Adipose- and Wharton‟s Jelly-Derived Mesenchymal Stromal Cells (K Kallmeyer, FA van Vollenstee, C Durandt, M Potgieter, MS Pepper). Faculty Day, University of Pretoria, 19-20 August 2014. Dr. Marco Alessandrini 1. Basic sciences posters, 3rd prize: Mesenchymal Stem Cell Therapy: Overview of Clinical Indications (M Alessandrini, M Potgieter, MS Pepper). Faculty Day, University of Pretoria, 19-20 August 2014. Renier Myburgh 1. Posters, 2nd prize. Gene engineering an HIV resistant immune system (R Myburgh, MS Pepper, P Salmon, KH Krause and RF Speck RF). World Innovation Day “Innovation for Health Competition”, Geneva, Switzerland, 28‐29 August 2014. Antoinette Colic

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1. Oral presentation, 1st prize. Pharmacogenetics of CYP2B6, 2A6 and UGT2B7: relevance to HIV treatment in African populations (A Colic, M Alessandrini and MS Pepper). Genomics Research Institute Seminar Day, University of Pretoria, 31 October 2014.

EXTERNAL EXAMINER Undergraduate course external examiner Midrand Graduate Institute - Medical Biotechnology course (2008-2009) University of the Witwatersrand - Molecular Medicine course for second year MBBCh students (2009-present) - School of Animal, Plant and Environmental Sciences (2010) PhD Thesis examiner - Britt Ingrid Drögemöller, Stelenbosch University (South Africa). October 2013. Thesis title: Investigation of genetic variation contributing to antipsychotic treatment response in a South African first episode schizophrenia cohort. - Anabela Correira Pereira Picton, University of the Witwatersrand (South Africa). May 2013. Thesis title: HIV-1 coreceptor CCR5: gene characterization anmd expresion. - H. J. Kotzé, North-West University (South Africa). July 2010. Thesis title: Evaluation of specific genotypes in the context of the type 2 diabetes risk phenotype in the black South African population. - Dr. Benoit Jenny, University of Geneva (Switzerland). July 2010. Thesis title: A neural stem/progenitor cell based approach for brain repair. - Fabienne Baffert, Université Joseph Fourier Grenoble I (Grenoble). March 2001. Thesis title: Effets d‟une exposition prolongée à l‟hypoxie sur la réorganisation des cellules endothéliales ensemencées sur matrice de fibrine. - Etienne Régulier, Université Louis Pasteur (Strasbourg). January 2001. Thesis title: Thérapie génique du cancer par transfert adénoviral de genès codant des chimiokines, cytokines et facteurs anti-angiogéniques. - Thomas Christen, Université de Genève (Switzerland). November 2000. Thesis title: Porcine coronary artery smooth muscle cells: phenotypic features and implication in restenosis. - Ingrid Struman, Université de Liège (Belgium). May 1999. Thesis title: Etude des propriétés angiogéniques des membres de la famille prolactine/hormone de croissance humanie et de leurs fragments N-terminaux de 16 kDa. - Arianna Caprioli, Université de Paris 6 (France). December 1997. Thesis title: L‟allantoïde, un des sites de production de cellules souches hématopoïétiques et de progéniteurs endothéliaux chez l‟embryon d‟Oiseau. LLD Thesis examiner - Paul Tobias Mtunuse, University of South Africa (South Africa). May 2013. Thesis title: The right to confidentiality in the context of HIV/AIDS. Habilitation Thesis examiner - Anne Eichmann, Institut d‟Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne, et Université de Marne-la Vallée (France). Mémoire d‟habilitation à diriger des recherches (HDR): Caracterisation moléculaire des précurseurs vasculaires embryonnaires. 1 December 2000. - Luc Pardanaud, Institut d‟Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne, et Université de Marne-la Vallée (France). Mémoire d‟habilitation à diriger des recherches (HDR): Aspects Cellulaires et Moléculaires du Developpement Vasculaire. 1 December 2000. Other - Florence Gandillon, Swissbody Pilates, Geneva (Switzerland). Mémoire : La méthode Pilates dans un contexte de postreeducation suite à une tetraparesie. 28 April 2013.

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RESEARCH

RESEARCH FUNDING Project title or student name Study of the transcriptome profiles of mesenchymal stem cells from human tissues Extramural Unit: Stem Cell Research and Therapy Fluidigm C1/Biomark single cell transcriptomics and genomics platform

Dr Sharon Kappala

Dr Ahmed Oloyo

Karlien Kallmeyer

Karlien Kallmeyer

Lara Contu

Elize Wolmarans Sasha Reznichenko Transcriptome analysis of hematopoietic stem cells expanded in culture FacsAria Fusion Cell Sorter

Evaluation of the effectiveness of a microarray based diagnostic tool (AMLprofiler) for acute

Funding body National Health Laboratory Services Research Trust South Afrcian Medical Research Council National Research Foundation: Infrastructure Funding Instruments (NEP/NNEP) University of Pretoria Vice-Chancellor's Post-Doctoral Fellowship Programme University of Pretoria Vice-Chancellor's Post-Doctoral Fellowship Programme National Research Foundation Scarce Skills Development Fund Doctoral Scholarship Ernst and Ethel Eriksen Trust PhD bursary Deutscher Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary National Research Foundation Internship National Research Foundation Internship Institutional Research Theme for Genomics, University of Pretoria National Research Foundation: Infrastructure Funding Instruments (NEP/NNEP) National Health Laboratory Services Research Trust

Amount R 491 600

Date 2015

R 1 000 000

04/2015 for 5 years 2014/2015

R 11 970 000

Notes

Includes 1/3 contribution from UP

R 200 000pa

2 years 2013-2015

Personal use

R 200 000pa

2 years 2014-2016

Personal use

R 100 000pa

3 years 2014-2016

Personal use

R 12 000

2014

Personal use

R 90 000pa

3 years 2014-3016

Personal use

R 92 347.20

2014-2015

Personal use

R 92 347.20

2014-2015

Personal use

R 84 000

2014

R 12 084 000

2014

R 90 000

2014-2016

Includes 1/3 contribution from UP

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myeloid leukaemia (AML) relative to current diagnostic modalities in the South African context Stem cell research and therapy: addressing South Africa‟s disease burden

Medical Research Council: SA University Flagship Projects Swiss South African Joint Research Programme

R 16 500 000

2014-2016

Category 1 award

R 1 200 000

2014-2016

Development of computational resources to support analysis of Southern African Human genomes

National Research Foundation: National Bioinformatics Functional Genomics Programme (NBIG)

R 931 000

2013-2015

Co-applicant with Profs. Roberto Speck (Zurich) and Krause (Geneva) Co-applicant with Prof. Alan Christoffels and the Southern African Human Genome Programme

Mesenchymal stem cell transcriptome analysis

National Research Foundation: National Bioinformatics Functional Genomics Programme (NBIG) Wellcome Trust

R 317 470

2013-2015

R 70 000

2013

Deutscher Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary National Research Foundation Internship National Research Foundation Innovation Doctoral Scholarship Faculty of Health Sciences, University of Pretoria - Research Assistant post Faculty of Health Sciences, University of Pretoria - Research Assistant post Council for Scientific and Industrial Research University of Pretoria

R 60 000pa

2013-2104

Personal use

R 72 600

2013-2014

Personal use

R 100 000pa

2013-2015

Personal use

R 40 000

2013

Personal use

R 40 000

2013

Personal use

R 30 000

2013

R 100 000

2013

Institutional Research Theme for Genomics, University of Pretoria

R 167 120

2013

Gene engineering HIV resistant cells

Genomics research on indigenous populations: exploring the concept of genomic sovereignty with the San community of southern Africa Carla Dessels

Jeanne van Rensburg Juanita Mellet

Danielle de Villiers

Isabella Rangaka

Cell delivery for soft tissue augmentation A molecular investigation of cystic fibrosis in South Africa A molecular investigation of cystic fibrosis in South Africa

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Dr. Cheryl Stewart

Madelein-Meissner Roloff and Karnien Kallmeyer

Jeanne van Rensberg

Southern African Human Genome Programme Public cord blood bank feasibility study Isabella Rangaka Juanita Mellet and Danielle de Villiers Dr. Marco Alessandrini

Dr. Chrisna Durandt

Dr. M. Potgieter

Dr. M. Potgieter

Tyren Dodgen

Isabella Rangaka Karlien Kallmeyer

Carlo Jackson

Fiona van Vollenstee

University of Pretoria Vice-Chancellor's Post-Doctoral Fellowship Programme Faculty of Health Sciences, University of Pretoria - Research Assistant post Faculty of Health Sciences, University of Pretoria - Research Assistant post Department of Science and Technology

R 200 000pa

2012-2014

Personal use

R 40 000

2012

Personal use

R 40 000

2012

Personal use

R 2 000 000

2012

Co-applicant with Prof. Michele Ramsay

Medical Research Council Medical Research Council National Research Foundation Internship National Research Foundation Scarce Skills Development Fund University of Pretoria Clinical research coordinator University of Pretoria Research Fellowship Programme Medical Research Council Post-doctoral scholarship Deutscher Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary National Research Foundation Internship National Research Foundation Freestanding and Innovation Scholarship Deutscher Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary Faculty of Health Sciences, University

R 322 660

2012

R 60 000

2012

Personal use

R 144 000

2012-2013

Personal use

R 190 000pa

2012-2014

R 160 000 personal use R 30 000 research

R 150 000pa

2012-2013

Personal use

R 680 000

2010-2013

Personal use

R 250 000

2011-2012

Personal use

R 65 000

2011

Personal use

R 87 120

2011-2012

Personal use

R 60 000pa

2011-2012

Personal use

R 65 000pa

2011-2014

Personal use

R 40 000

2011

Personal use

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Carlo Jackson and Karlien Kallmeyer

Southern African Human Genome Programme Soft tissue augmentation – cell delivery using DermapearlTM Carlo Jackson

Karlien Kallmeyer, Fiona van Vollenstee Fatima Barmania Cytochrome P450 2D6 polymorphisms in weight gain and movement disorders associated with risperidone treatment Gene therapy for HIV/AIDS Arinda Eloff, Amy Kopke Understanding technology transfer at South African universities: towards establishing trends and best practice for the establishment of Communities of Practice among Southern African and African universities Investigation of MC4 receptor polymorphisms in the South African obese population CYP2D6 polymorphisms associated with risperidone CYP2D6 and CYP2C19 pharmacogenetics as a preprescription predictive tool for drug toxicity and efficacy in the South African population Pharmacogenetics of CYP2D6 and CYP2C19

Utilization of AmpliChip pharmacogenetic technology for pre-prescription genotyping

of Pretoria - Research Assistant post Faculty of Health Sciences, University of Pretoria - Research Assistant post Department of Science and Technology

R 40 000

2011

Personal use

R 450 000

2010-2011

Co-applicant with Prof. Michele Ramsay

Council for Scientific and Industrial Research Faculty of Health Sciences, University of Pretoria - Research Assistant post National Research Foundation Internship Innovation Master‟s Scholarship National Health Laboratory Services Research Trust

R 150 000

2010-2011

R 40 000

2010

Personal use

R 132 000

2010-2011

Personal use

R 60 000

Personal use

R 324 500

2010 2011 2010-2011

National Research Foundation National Research Foundation Internship World Bank Institute

R 1 920 000

2009-2011

R 132 000

2009-2010

R 85 000

2009

National Health Laboratory Services Research Trust National Research Foundation Unlocking the future National Research Foundation - Focus Area Call

R 51 300

2009

R 200 000

2008-2009

R 209 000

2007-2008

National Research Foundation Thuthuka. Women in research AMPATH National Pathology Support Services

R 151 000

2007

R 648 000

2006-2009

Personal use

Awarded to Dr. Chrisna Durandt

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Dr. Chrisna Durandt

Pre-treatment genotyping as a predictor of therapeutic outcome Molecular mechanisms of lymphangiogenesis and lymphatic tumor cell dissemination

Genomic analysis of endothelial cells during angiogenesis Lymphatic endothelial cells: isolation, characterisation and development of functional assays Effect of SSR128129, an FGF-R1 antagonist, on angiogenesis in vitro and lymphangiogenesis and tumor metastasis in vivo Pathophysiology and consequences of tissue ischemia Effects of 8-prenylnaringenin, a novel highly phytoestrogen, on angiogenesis and the endothelial cell proteolytic repertoire Evaluation of rNAPc2 in random dorsal skin flap model of acute ischemia Pathophysiology and consequences of tissue ischemia Hypoxia-regulated gene expression in endothelial cells – a therapeutic target ? Mechanisms of lymphangiogenesis and its role in tumor metastasis Genomic analysis of endothelial cells during angiogenesis Hypoxia-regulated gene expression in endothelial cells - a therapeutic target? Hypoxia-regulated gene expression in endothelial cells - a therapeutic target? Regulation of angiogenesis: the role of endothelial-

University of Pretoria, Pretoria, Research Fellowship National Health Laboratory Services Research Trust Swiss National Science Foundation

R 330 000

2006-2008

R 60 000

2006

SFr 319 925

2004-2007

Merck KGaA, Darmstadt, Germany

€ 184 800

2003-2005

Novartis Pharma AG, Basel, Switzerland

SFr 211 716

2003-2004

Sanofi-Synthelabo Recherche, Toulouse, France

SFr 62 666.24

2003

Société Académique de Genève

SFr 15 000

2002

Swiss Foundation for Nutrition Research

SFr 20 000

2002

Corvas International Inc

SFr 43 000

2002

Crédits d‟investissement de la Faculté de Médecine, Université de Genève Fondation Novartis

SFr 40 000

2002

SFr 43 157

2001

Swiss National Science Foundation

SFr 335 000

2001-2004

Merck KGaA, Darmstadt

€ 153 387

2000-2002

Recherche Suisse Contre le Cancer

SFr 139 500

2000-2002

Rentenanstalt Swiss Life

SFr 20 000

2000

Fondation Suisse de Cardiologie

SFr 125 000

2000

Grant returned to the Swiss National Science Foundation because of departure from Switzerland

- 24 -

perivascular cell interactions and hypoxia Angiogenesis and vascular Fondation SFr 23 327 1999 morphogenesis Schmidheiny Positive and negative Fondation Carlos et SFr 25 000 1997 regulation of angiogenesis: Elise de Reuter clinical applications of basic science research Establishing an "angiogenic Ligue Genevoise SFr 19 517.25 1996 profile" for cancer patients contre le Cancer Angiogenesis and Fondation Sandoz SFr 25 000 1994 tubulogenesis in the rodent pour l'avancement des mammary gland and sciences medicoendocrine pancreas biologiques Co-applicant with Dr. M.-L. Bochaton-Piallat (Dept. Pathology, University Medical Center, Geneva, Switzerland) Arterial smooth muscle Swiss National SFr 227 000 2002-2005 heterogeniety: implications Science Foundation for atherosclerosis and restenosis Co-applicant with Dr. B. Pittet-Cuenod (Div. Plastic and Reconstructive Surgery, Geneva University Hospital, Geneva, Switzerland) Improving survival and repair Swiss National SFr 167 000 2002-2005 of ischemic tissue Science Foundation Improving the survival of skin Swiss National SFr 206 250 1998-2001 grafts and skin flaps Science Foundation Co-applicant with Dr. C. Morel (Institut de Physique des Hautes Eneries, Université de Lausanne, Lausanne, Switzerland) Design and construction of a Swiss National SFr 769 982 2001-2003 high resolution PET camera Science Foundation for small animals. Co-applicant with Dr. M.-A. Brundler (Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland) Angiogenesis, a possible Ligue Genevoise SFr 57 000 1998/1999 prognostic marker in Barrett‟s contre le Cancer esophagus, Barrett‟s dysplasia and adenocarcinoma of the lower esophagus and gastric cardia? Co-applicant with Dr. R. Montesano (Dept. Morphology, University of Geneva Medical Center, Geneva, Switzerland) Molecular mechanisms of Swiss National SFr 750 000 1995-2000 capillary and epithelial Science Foundation morphogenesis Molecular mechanisms of Swiss National SFr 524 000 1992-1995 capillary and epithelial Science Foundation morphogenesis Analyse moléculaire du Société Académique SFr 15 970 1990 processus de néoformation de de Genève vaisseaux sanguins Molecular mechanisms of Swiss National SFr 300 000 1989-1992 angiogenesis in vitro Science Foundation Studies on the molecular Sir Jules Thorn SFr 90 870 1988-1991 mechanisms of the Charitable Overseas neovascularization process Trust (angiogenesis)

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Mechanisms and regulation of blood capillary proliferation in diabetes: an in vitro approach Analyse moléculaire du processus de néovascularisation des tumeurs

Juvenile Diabetes Foundation International

$ 79 950

1988-1989

Bal de Genève en faveur de la Recherche sur le Cancer

SFr 49 000

1988

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MICHAEL PEPPER THESES

PhD Thesis Faculty of Science, University of Geneva, 1990. "Invasive properties of endothelial cells: contributions to the process of angiogenesis." Thesis no. 2421, 150 pages. MD Thesis Faculty of Medicine, University of Geneva, 1992. "Angiogenesis in vitro: interactions between angiogenesis-modulating cytokines and the role of balanced extracellular proteolysis." Thesis no. 9398, 120 pages. Privat Docent Thesis Faculty of Medicine, University of Geneva, 1997. "Positive and negative regulation of angiogenesis: from cell biology to the clinic." 203 pages.

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PUBLICATIONS

Original Publications (peer review journals) Total impact factor: 653.53 Number of publications: 121 (9 without IF) Mean impact factor per publication: 5.84 (As of June 2014)

No.

Authors

Title

Journal

1

Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.

J. Cell. Physiol. 132: 509-516 (1987).

2

Pepper M.S., Vassalli J.-D., Montesano R. and Orci L.

3

Montesano R., Pepper M.S., Belin D., Vassalli J.-D. and Orci L. Pepper M.S., Spray D.C., Chanson M., Montesano R., Orci L. and Meda P. Pepper M.S., Belin D., Montesano R., Orci L. and Vassalli J.-D.

Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors. Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells. Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases. Junctional communication is induced in migrating capillary endothelial cells. Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. Increased proteolytic activity is responsible for the aberrant morphogenetic behaviour of endothelial cells expressing the middle T oncogene. In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells.

Chondrocytes inhibit endothelial sprout formation in vitro: evidence for involvement of a transforming growth factor-beta. Plasminogen activator inhibitor-1 is induced in microvascular endothelial cells by a chondrocyte-derived transforming growth factor-beta. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Coupling and connexin 43 expression in microvascular and large vessel

4

5

6

Montesano R., Pepper M.S., Möhle-Steinlein U., Risau W., Wagner E.F. and Orci L.

7

Meda P., Chanson M., Pepper M., Giordano E., Bosco D., Traub O., Willecke K., El Aoumari A., Gros D., Beyer E.C., Orci L. and Spray D.C. Pepper M.S., Montesano R., Vassalli J.-D. and Orci L.

8

9

Pepper M.S., Montesano R., Orci L. and Vassalli J.-D.

10

Pepper M.S., Ferrara N., Orci L. and Montesano R.

11

Pepper M.S., Montesano R., El Aoumari A., Gros D., Orci L.

Impact Factor 4.218

J. Cell Biol. 105: 2535-2541 (1987). J. Cell. Physiol. 134: 460-466 (1988).

10.822

J. Cell Biol. 109: 3027-3038 (1989). J. Cell Biol. 111: 743-755 (1990).

10.822

Cell 62: 435-445 (1990).

31.957

Exp. Cell Res. 192: 469-480 (1991).

3.557

J. Cell. Physiol. 146: 170-179 (1991).

4.218

Biochem. Biophys. Res. Commun. 176: 633-638 (1991).

2.406

Biochem. Biophys. Res. Commun. 181: 902-906 (1991).

2.406

Am. J. Physiol. 262 (Cell Physiol.

3.711

4.218

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and Meda P.

endothelial cells.

12

Pepper M.S., Matsumoto K., Nakamura T., Orci L. and Montesano R.

13

Pepper M.S., Sappino A.-P., Montesano R., Orci L. and Vassalli J.-D. Pepper M.S. and Meda P.

Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells. Plasminogen activator inhibitor-1 is induced in migrating endothelial cells.

14

15

Pepper M.S., Ferrara N., Orci L. and Montesano R.

16

Pepper M.S., Vassalli J.-D., Orci L. and Montesano R. Fotsis T., Pepper M., Aldercreutz H., Fleischmann G., Hase T., Montesano R. and Schweigerer L. Pepper M.S., Sappino A.-P., Stocklin R., Montesano R., Orci L. and Vassalli J.-D. Montesano R., Pepper M.S. and Orci L.

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Meda P., Pepper M.S., Traub O., Willecke K., Gros D., Beyer E., Nicholson B., Paul D. and Orci L. Pepper M.S., Wasi S., Ferrara N., Orci. L and Montesano R. Fotsis T., Zhang Y., Pepper M.S., Aldercreutz H., Montesano R. Nawroth P.P. and L. Schweigerer. Pepper M.S., Vassalli J.-D., Wilks J.W., Schweigerer L., Orci. L and Montesano R. Pepper M.S., Ferrara N., Orci L. and Montesano R. Soriano, J.V., Pepper M.S., Nakamura T., Orci. L and Montesano R. Mandriota S.J., Seghezzi G., Vassalli J.-D., Ferrara N., Wasi S., Mazzieri R., Mignatti P. and Pepper M.S. Pepper M.S., Soriano J.V., Menoud P.-A., Sappino A.-P.,

Basic fibroblast growth factor increases junctional communication and connexin 43 expression in microvascular endothelial cells. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biphasic effect of TGF1 on in vitro angiogenesis. Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

Upregulation of urokinase receptor expression on migrating endothelial cells. Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts. Differential expression of gap junction connexins in endocrine and exocrine glands. In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells. The endogenous estrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth. Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis. Leukemia inhibitory factor (LIF) inhibits in vitro angiogenesis. Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. Modulation of hepatocyte growth factor and c-met expression in the rat

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Biochem. Biophys. Res. Commun. 189: 824-831 (1992).

2.406

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Exp. Cell Res. 210: 298-305 (1994).

3.557

Nature 368: 237-239 (1994).

38.597

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9.737

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4.717

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Orci, L. and Montesano R. 28

Mandriota S.J., Menoud P.-A. and Pepper M.S.

29

Montesano R., Kumar S., Orci L., and Pepper M.S.

30

French L.E., Soriano J.V., Montesano R. and Pepper M.S.

31

Zimrin A.B., Pepper M.S., McMahon G.A., Nguyen F., Montesano R., Maciag T.

32

Thommen R., Humar R., Misevic G., Pepper M.S., Hahn A.W.A., John M. and Battegay E.J. Gorden, D.L., Mandriota S.J., Montesano R., Orci L. and Pepper M.S. Anande-Apte B., Pepper M.S., Voest E., Montesano R., Olsen B., Murphy G., Apte S.S. and Zetter B. Anande-Apte B., Pepper M.S., Voest E., Montesano R., Olsen B., Murphy G., Apte S.S. and Zetter B. Sabapathy K.T., Pepper M.S., Kiefer F., Möhle-Steinlein U., Tacchini-Cottier F., Fetka I., Breier G., Risau W., Montesano R. and Wagner E.F. Fotsis T., Pepper M.S., Aktas E., Breit S., Rasku S., Adlercreutz H., Wähälä K., Montesano R. and Schweigerer L. Masouyé I., Hagens G., Van Kuppevelt T.H., Madsen P., Saurat J.-H., Veerkamp J.H., Pepper M.S. and Siegenthaler G. Mandriota S.J. and Pepper M.S.

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Terris B., Scoazec J.-Y., Rubbia L., Bregeaud L., Pepper M.S., Ruszniewski P., Belghiti J.,

mammary gland during pregnancy, lactation and involution. Transforming growth factor 1 downregulates vascular endothelial growth factor receptor-2/flk-1 expression in vascular endothelial cells. Synergistic effect of hyaluronan oligosaccharides and vascular endothelial growth factor on angiogenesis in vitro. Modulation of clusterin gene expression in the rat mammary gland during pregnancy, lactation and involution. An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro. PDGF-BB increases endothelial migration and cord movements during angiogenesis in vitro.

J. Biol. Chem. 271: 11500-11505 (1996).

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Lab. Invest. 75: 249-262 (1996).

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Biol. Reprod. 55: 1213-1220 (1996).

4.027

J. Biol. Chem. 271: 32499-32502 (1996).

4.651

J. Cell. Biochem. 64: 403-413 (1997).

3.062

Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro. Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3 (TIMP-3).

Transplantation 63: 436-443 (1997).

3.781

Invest. Ophth. Vis. Sci. 38: 817-823 (1997).

3.441

Untitled - reply

Invest. Ophth. Vis. Sci. 38: 2433-2434 (1997).

Polyoma middle T-induced vascular tumor formation: the role of the plasminogen activator/plasmin system.

J. Cell Biol. 137: 953-963 (1997).

10.822

Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis.

Cancer Res. 57: 2916-2921 (1997).

8.650

Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein.

Circ. Res. 81: 297-303 (1997).

11.861

Vascular endothelial growth factorinduced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor. Expression of vascular endothelial growth factor in digestive neuroendocrine tumors.

J. Cell Sci. 110: 2293-2302 (1997).

5.877

Histopathology. 32:133-138 (1998).

2.857

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40

Fléjou J.-F. and Degott C. Bochaton-Piallat M.-L., Gabbiani G. and Pepper M.S.

41

Pepper M.S. and Mandriota S.J.

42

Cavallaro U., Wu Z.-H., Di Palo A., Montesano R., Pepper M.S., Maier J.A.M. and Soria M.R.

43

Mandriota S.J. and Pepper M.S.

44

Olofsson B., Korpelainen E., Pepper M.S., Mandriota S.J., Aase K., Kumar V., Gunji Y., Jeltsch M.., Shibuya M., Alitalo K. and Eriksson U. Pepper M.S., Mandriota S.J., Jeltsch M. Kumar V. and Alitalo K.

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48

Lucas R., Garcia I., Donati Y.R.A., Hribar M., Mandriota S.J., Giroud C., Buurman W.A., Fransen L., Suter P.M., Nuñez G., Pepper M.S. and Grau G.E. Lucas R., Holmgren L., Garcia I., Jiminez, B., Mandriota S.J., Borlat F., Sim B.K.L., Wu Z., Grau G.E., Shing Y., Soff G.A., Bouck N. and Pepper M.S. Collo G. and Pepper M.S.

49

Montesano R., Soriano J.V., Hosseini G., Pepper M.S. and Schramek H.

50

Neuville P., Yan Z., Gidlöf A., Pepper M.S., Hansson G.K., Gabbiani G. and Sirsjö A.

51

Soriano J.V., Pepper M.S., Taupenot L., Bader M.-F., Orci L. and Montesano R. Miralbell R., Tolnay M., Bieri S., Probst A., Sappino A.-P.,

52

Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Regulation of vascular endothelial growth factor receptor-2 (Flk-1) expression in vascular endothelial cells. Fibroblast growth factor-2 stimulates migration of Kaposi‟s sarcoma-like vascular spindle cells by HGFdependent relocalization of the urokinase receptor. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. VEGF-B binds to VEGFR-1 and regulates plasminogen activator activity in endothelial cells.

Circ. Res. 82: 1086-1093 (1998).

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Exp. Cell Res. 241: 414-425 (1998).

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FASEB J. 12: 1027-1034 (1998).

5.704

Circ. Res. 83: 852-859 (1998).

11.861

Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro, and alters endothelial cell extracellular proteolytic activity. Specific role of TNF receptor 2 in direct, but not in sensitized TNFmediated cytotoxicity in microvascular endothelial cells.

J. Cell. Physiol. 177: 439-452 (1998).

4.218

Eur. J. Immunol. 28: 3577-3586 (1998).

4.970

Multiple forms of angiostatin induce apoptosis in endothelial cells.

Blood 92: 4730-4741 (1998).

9.060

Endothelial cell integrin 51 expression is modulated by cytokines and during migration in vitro. Constitutively active MAPK kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in MDCK epithelial cells. Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through a RAR-independentsignalling pathway. Chromogranin A increases deposition of basement membrane components by mammary epithelial cells. Pediatric medulloblastoma: prognostic value of p53, bcl-2, Mib-1, and

J. Cell Sci. 112: 569-578 (1999).

5.877

9.737 Proc. Natl. Acad. Sci. USA. 95: 1170911714 (1998).

Cell Growth Differ. 10: 317-332 (1999).

Arterioscl. Thromb. Vasc. Biol. 19: 1430-1436 (1999).

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Biochem. Biophys. Res. Commun. 259: 563-568 (1999). J. Neuro-oncol. 45: 103-110 (1999).

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Berchtold W., Pepper M.S. and Pizzolato G.: Zhao H., Bojanowski K., Ingber D.E., Panigrahy D., Pepper M.S., Montesano R. and Shing Y. Fuhrmann-Benzakein E., Ma M.N., Rubbia-Brandt L., Mentha G., Rufenacht D., Sappino A.-P. and Pepper M.S. Tenan M., Fulci G., Albertoni M., Diserens A.-C., Hamou M.F., El Atifi-Borel M., Feige J.J., Pepper M.S. and van Meir E.G. Mandriota S.J., Pyke C., Di Sanza C., Quinodoz P., Pittet B. and Pepper M.S.

Pepper M.S., Baetens D., Mandriota S.J., Di Sanza C., Oikemus S., Lane T.F., Soriano J.V., Montesano R. and IruelaArispe M.L. Taraboletti G., Sonzogni L., Vergani V., Hosseini G., Ceruti R., Ghilardi C., Bastone A., Toschi E., Borsotti P., Scanziani E., Giavazzi R., Pepper M.S., Stetler-Stevenson W. and Bani M.R. Cavallaro U., Castelli V., Perilli A., Dossi R., Giavazzi R., Pepper M.S., Soria M.R. and Montesano R. Fuhrmann-Benzakein E., Garcia-Gabay I., Pepper M.S., Vassalli J.-D. and Herrera P.L. Scheidegger P., Weiglhofer W., Suarez S., Console S., Waltenberger J., Pepper M.S., Jaussi R. and Ballmer-Hofer K. Mandriota S.J., Jussila L., Jeltsch M., Compagni A., Baetens D., Prevo R., Banerji S., Huarte J., Montesano R., Jackson D., Orci L., Alitalo K., Christofori G. and Pepper M.S. Lucas R., Montesano R., Pepper M.S., Hafner M., Sablon E., Dunant Y., Grau G.E., De Baetselier P., Männel D. and Fransen L. Cavallaro U., Perilli A., Castelli V., Pepper M.S. and Soria M.R.

microvessel density. A new role for tRNA and its fragment purified from urinary bladder carcinoma conditioned medium: inhibition of endothelial cell growth. Elevated levels of angiogenic cytokines in the plasma of cancer patients.

J. Cell. Biochem. 76: 109-117 (2000).

3.062

Int. J. Cancer. 85: 40-45 (2000).

6.198

Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells.

J. Exp. Med. 191: 1789-1798 (2000).

13.214

Hypoxia-inducible angiopoietin-2 expression is mimicked by diphenylene iodonium and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation and involution.

Am. J. Pathol. 156: 2077-2089 (2000).

4.522

Dev. Dynam. 218: 507-524 (2000).

2.590

Post-transcritpional stimulation of endothelial cell matrix metalloproteinases 2 and 1 by endothelioma cells.

Exp. Cell Res. 258: 384-394 (2000).

3.557

Characterization of novel clonal murine endothelial cell lines with an extended life span.

In Vitro Cell. Dev. An. 36: 299-308 (2000).

1.289

Cre-mediated inducible and irreversible control of gene expression using a single transgene. Signalling properties of an HIVencoded angiogenic peptide mimicking vascular endothelial growth factor activity. Vascular endothelial growth factor-Cmediated lymphangiogenesis promotes tumour metastasis.

Nucleic Acids. Res. 28: e99 (5 pages) (2000). Biochem. J. 353: 569-578 (2001).

8.278

EMBO J. 20: 672-682 (2001).

8.822

Lectin-deficient TNF mutants display comparable anti-tumor but reduced pro-metastatic potential as compared to the wild-type molecule.

Int. J. Cancer 91: 543-549 (2001).

6.198

FGF-2 promotes disassembly of actin cytoskeleton and shape changes in

Microvasc. Res. 61: 211-214 (2001).

2.929

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murine vascular cells. Kwak B.R., Pepper M.S., Gros Inhibition of endothelial wound repair D.B. and Meda P. by dominant negative connexin inhibitors. Rinsch C., Quinodoz P., Pittet Delivery of FGF-2 but not VEGF by B., Alizadeh N., Baetens D., encapsulated genetically engineered Montadon D., Aebischer P. and myoblasts improves survival and Pepper M.S. vascularization in a model of acute skin flap ischemia. Pepper M.S., Rosnoblet C., Di Synergistic induction of tissue-type Sanza C. and Kruithof E.K.O. plasminogen activator (tPA) by vascular endothelial growth factor and basic fibroblast growth factor and localization of tPA to Weibel-Palade bodies in bovine microvascular endothelial cells. Cavallaro U., Tenan M., Castelli The response of bovine endothelial V., Perilli A, Maggiano N., Van cells to FGF-2 and VEGF is dependent Meir E., Montesano R., Soria on their site of origin: relevance to the M.R., and Pepper M.S. regulation of angiogenesis. Kirkin V., Mazitschek R., Characterisation of indolinones which Krishnan J., Steffen A., preferentially inhibit VEGF-C- and Waltenberger J., Pepper M.S., VEGF-D-induced activation of Giannis A. and Sleeman J.P. VEGFR-3 rather than VEGFR-2. Tille J.-C., Wood J., Mandriota Vascular endothelial growth factor S.J., Schnell C., Ferrari S., (VEGF) receptor-2 antagonists inhibit Mestan J., Zhu Z., Witte L. and VEGF- and basic fibroblast growth Pepper M.S. factor-induced angiogenesis in vivo and in vitro. Gannon G., Mandriota S.J., Cui Overexpression of VEGF-A165 L., Baetens D., Pepper M.S. and enhances tumor angiogenesis but not Christofori G. metastasis during -cell carcinogenesis. Lucas R., Lijnen H.R., Increased angiostatin levels in Suffredini A.F., Pepper M.S., bronchoalveolar lavage fluids from Steinberg K.P., Martin T.R. and ARDS patients and from human Pugin J. volunteers after lung instillation of endotoxin. Hao H., Ropraz P., Verin V., Heterogeniety of smooth muscle cell Camenzind E., Geinoz A., populations cultured from pig Pepper M.S., Gabbiani G. and coronary artery. Bochaton-Piallat M.L. Van Trappen P.O., Ryan A., A model for co-expression pattern Carroll M., Lecoeur C., Goff L., analysis of genes implicated in Gyselman V.G., Young B.D., angiogenesis and tumour cell invasion Lowe D.G., Pepper M.S., in cervical cancer. Shepherd J.H. and Jacobs I.J. Tille J.C. and Pepper M.S. Mesenchymal cells potentiate vascular endothelial growth factor-induced angiogenesis in vitro. Podgrabinska S., Braun P., Molecular characterization of Velasco P., Kloos B., Pepper lymphatic endothelial cells. M.S. and Skobe M. Podgrabinska S., Braun P., Velasco P., Kloos B., Pepper

Correction

Mol. Biol. Cell 12: 831-845 (2001).

4.803

Gene Ther. 8: 523-533 (2001).

4.321

Thromb. Haemostasis 86: 702-709 (2001).

6.094

J. Cell. Biochem. 82: 619-633 (2001).

3.062

Eur. J. Biochem. 268: 5530-5540 (2001).

4.250

J. Pharmacol. Exp. Ther. 299: 1073-1085 (2001).

3.891

Cancer Res. 62: 603-608 (2002).

8.650

Thromb. Haemostasis 87: 966-971 (2002).

6.094

Arterioscl. Thromb. Vasc. Biol. 22: 1093-1099 (2002). Brit. J. Cancer 87: 537-544 (2002).

6.338

Exp. Cell Res. 280: 179-191 (2002).

3.557

Proc. Natl. Acad. Sci. USA 99: 16069-16074 (2002). Proc. Natl. Acad. Sci. USA

9.737

5.082

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77

78

79 80

81

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M.S. and Skobe M. Tille J.C., Wang X., Lipson K.E., McMahon G., Ferrara N., Zhu Z., Hicklin D.J., Sleeman J.P., Eriksson U., Alitalo K. and Pepper M.S. Tille J.C., Morris M.A., Bründler M.A and Pepper M.S. Wernert N., Okuducu A.F. and Pepper M.S. Van Trappen P.O., Steele D., Lowe D.G., Baithun S., Beasley N., Thiele W., Weich H., Krishnan J., Shepherd J.H., Pepper M.S., Jackson D.G, Sleeman J.P. and Jacobs I.J. Nisato R.E., Tille J.C., Jonczyk A., Goodman S.L. and Pepper M.S. Zhang H., Vutskits L., Pepper M.S. and Kiss J.Z. Pepper M.S., Hazel S.J., Hümpel M. and Schleuning W.D. Persaud K., Tille J.C., Liu M., Zhu Z., Jimenez X., Peirera D., Miao H.Q., Witte L., Pepper M.S. and Pytowski B.

Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-CΔNΔC- and VEGF-A-induced angiogenesis in vitro.

100: 4970 (2003). Exp. Cell Res. 285: 286-298 (2003).

3.557

Familial predisposition to tufted angioma – identification of blood and lymphatic vascular components. Ets 1 is expressed in capillary blood vessels but not in lymphatics. Expression of vascular endothelial growth factor (VEGF)-C and VEGFD, and their receptor VEGFR-3, during different stages of cervical carcinogenesis.

Clin. Genet. 63: 393-399 (2003).

4.247

J. Pathol. 200: 561-567 (2003). J. Pathol. 201: 544-554 (2003).

7.585

v3 and v5 integrin antagonists inhibit angiogenesis in vitro.

Angiogenesis 6: 105-119 (2003).

3.972

VEGF is a chemoattractant for FGF-2 stimulated neural progenitors.

J. Cell Biol. 163: 1375-1384 (2003). J. Cell Physiol. 199: 98-107 (2004).

10.822

J. Cell Sci. 117: 2745-2756 (2004).

5.877

J. Pathol. 203: 700-709 (2004).

7.585

Am. J. Pathol. 165: 11-24 (2004).

4.522

Clin. Cancer Res. 10: 6919-6928 (2004).

7.837

J. Surg. Res. 122: 263-273 (2004).

2.018

Brit. J. Nutr. 93: 317-323 (2005).

3.302

Oncogene 24:1689-1697 (2005).

7.357

Thromb. Haemostasis

6.094

8-Prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo. Involvement of the VEGF receptor-3 in capillary morphogenesis demonstrated with a human antihuman VEGFR-3 antibody that antagonizes receptor activation by VEGF-C. Aurrand-Lions M., JohnsonHemangiomas are formed by cells Leger C., Pepper M.S. and expressing high levels of integrin v 3 Imhof B.A. and lacking acetylated-LDL uptake. Nisato R.E., Harrison J.A., Generation and characterization of Buser R., Orci L., Rinsch C., telomerase-transfected human Montesano R., Dupraz P., lymphatic endothelial cells with an Pepper M.S. extended lifespan. Rubbia-Brandt L., Terris B., Lymphatic vessel density and VEGF-C Giostra E., Dousset B., Morel P. expression correlate with malignant and Pepper M.S. behavior in human pancreatic endocrine tumors. Alizadeh N., Pittet B., Pyke C., Active-site inactivated FVIIa (FVIIai) Baetens D., Montandon D., increases survival in a random skin Ezban M. and Pepper M.S. flap model of acute ischemia. Kiriakidis S., Högemeier O., Novel tempeh (fermented soyabean) Starcke S., Dombrowski F., isoflavones inhibit in vivo Hahne J.C., Pepper M., Jha H.C. angiogenesis in the chicken and Wernert N. chorioallantoic membrane assay. Soulié P., Carrozzino F., Pepper Membrane-type-1 matrix M.S., Strongin A.Y., Poupon metalloproteinase confers M.-F. and Montesano R. tumorigenicity on non-malignant epithelial cells. Zanetta L., Corada M., Downregulation of vascular Lampugnani M., Zanetti A., endothelial-cadherin expression is

7.585

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Breviario F., Moons L., Carmeliet P., Pepper M.S., and Dejana E. 92 Nisato R.E., Hosseini G., Sirrenberg C., Butler G.S., Crabbe T., Docherty A.J.P., Wiesner M., Murphy G., Overall C.M., Goodman S.L. and Pepper M.S. 93 Brundler M.A., Harrison J.A., de Saussure B., de Perrot M., Pepper M.S. 94 Buser R., Montesano R., Garcia I., Dupraz P. and Pepper M.S. 95 Jenny B., Harrison J.A., Baetens D., Tille J.C., Burkhardt K., Mottaz H., Kiss J.Z., Dietrich P.Y., De Tribolet N., Pizzolato G.P., Pepper M.S. 96 Friedrichs N., Hahne J.C., Pepper M.S., RommerscheidtFuss U., Stelzner F., Buettner R. and Wernert N. 97 Mahajan A.L., Tenorio X., Pepper M.S., Baetens D., Montandon D., Schlaudraff K.U., Pittet B. 98 Mathe Z., Dupraz P., Rinsch C., Thorens B., Bosco D., Zbinden M., Morel P., Berney T. and Pepper M.S. 99 Alizadeh N., Pepper M.S., Modarressi A., Alfo K., Schlaudraff K., Montandon D., Gabbiani G., Bochaton-Piallat M.L. and Pittet B. 100 Schlaudraff K.U., Bezzola T., Montandon D., Pepper M.S., Pittet B. 101 Schlaudraff K.U., Pepper M.S., Tkatchouk E.N., Ehrenburg I., Alizadeh N., Montandon D., Pittet B. 102 Pegu A., Qin S., Fallert Junecko B.A., Nisato R.E., Pepper M.S., Reinhart T.A. 103 Mabeta P. and Pepper M.S.

104 Hammer T., Tritsaris K., Hübschmann M.V., Pepper M.S., Nisato R.N. and Dissing S. 105 Jordaan D.W., Woodrow C. and Pepper M.S.

associated with an increase in vascular tumor growth and hemorrhagic complications. Dissecting the role of matrix metalloproteinases (MMP) and integrin v3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-type 1MMP and v3 are critical. Lymphatic vessel density in the neoplastic progression of Barrett oesophagus to adenocarcinoma. Bovine microvascular endothelial cells immortalized with human telomerase. Expression and localization of VEGFC and VEGFR-3 in glioblastomas and hemangioblastomas.

93: 1041-1046 (2005). Cancer Res. 65: 9377-9387 (2005).

8.650

J. Clin. Pathol. 59:191-195 (2006).

2.439

J. Cell. Biochem. 98: 267-286 (2006). J. Pathol. 209: 34-43 (2006).

3.062

Immunohistochemical quantification of lymph vessels, VEGF-C and VEGF receptor 3 in human sarcomas.

Histopathology 49: 87-88 (2006).

2.857

Progressive tissue injury in burns is reduced by rNAPc2.

Burns 32: 957-963 (2006).

1.799

Tetracycline-regulated expression of VEGF-A in beta-cells induces angiogenesis: improvement of engraftment following transplantation. Persistent ischemia impairs myofibroblast development in wound granulation tissue. A new model of delayed wound healing.

Cell Transplantation: 15: 621-636 (2006).

4.422

Wound Rep. Reg. 15: 809-816 (2007).

2.757

Mixed arterio-venous insufficiency in random skin flaps in the rat: is the application of medicinal leeches beneficial? Hypoxic preconditioning increases skin oxygenation and viability but does not alter VEGF expression or vascular density. Human lymphatic endothelial cells express multiple functional TLRs.

J. Surg. Res. 150: 85-91 (2008).

2.018

A comparative study on the antiangiogenic effects of DNA-damaging and cytoskeletal-disrupting agents. IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation. Banning private umbilical cord blood banks: a human rights analysis.

7.585

High Alt. Med. Biol. 2.122 9: 76-88 (2008).

J. Immunol. 180: 3399-3405 (2008). Angiogenesis 12: 81-90 (2009).

5.520

Microvasc. Res. 78: 25-32 (2009).

2.929

S. Afr. J. Hum. Rights 25: 126-151

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(2009). 106 Flister M.J., Wilber A., Hall K.L, Iwata C., Miyazono K., Nisato R., Pepper M.S., Zawieja D.C. and Ran S. 107 Slabbert M.N. and Pepper M.S.

Inflammation induces lymphangiogenesis through upregulation of VEGFR-3 mediated by NF-B and Prox1. “A room of our own?” Legal lacunae regarding genomic sovereignty in South Africa.

108 Dodgen T.M., Cromarty A.D. and Pepper M.S.

Quantitative plasma analysis using automated online solid-phase extraction with column switching LCMS/MS for characterising cytochrome P450 2D6 and 2C19 metabolism. Is South Africa on the verge of a medical malpractice litigation storm?

109 Pepper M.S. and Slabbert M.N.

110 Slabbert M.N., Maister B., Botes M. and Pepper M.S.

111 Ammar A., Mohammed R.A.A., Salmi M., Pepper M., Paish E.C., Ellis I.O. and Martin S.G. 112 Mabeta P. and Pepper M.S.

113 de Vries J., Slabbert M.N. and Pepper M.S.

114 de Vries J. and Pepper M.

115 Meissner-Roloff M., Young W.M., Rangaka I., Lombaard H., Dhai A., Tsotsi N. and Pepper M.S. 116 Alessandrini M., Klose K. and Pepper M.S.

117 Dodgen T.M., Hochfeld W.E., Fickl H., Asfaha S.M., Durandt C., Rheeder P., Drögemöller B.I., Wright G.E.B., Warnich L., Labuschagne D. de J., van Schalkwyk A., Gaedigk A. and Pepper M.S.

The application of the Consumer Protection Act in the South African health care context: concerns and recommendations. Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis. Inhibition of hemangioma development in a syngeneic mouse model correlates with bcl-2 suppression and the inhibition of Akt kinase activity. Ethical, legal and social issues in the context of the planning stages of the Southern African Human Genome Programme. Genomic sovereignty and the African promise: mining the African genome for the benefit of Africa. Pilot social feasibility study for the establishment of a public human umbilical cord blood stem cell bank in South Africa. Technology transfer practices at South African universities and science councils. Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study.

Blood 115: 418-429 (2010).

Tydskrif vir Hedendaagse Romeins-Hollandse Reg (J. Contemporary South African Roman-Dutch Law) 73: 432-450 (2010). J. Separation Science. 34: 1102-1110 (2011).

9.060

2.591

S. Afr. J. Bioethics Law 4: 29-35 (2011). Comp. Int. Law J. Southern Afr. (CILSA). 94: 168-203 (2011). Anal. Cell Pathol. 34: 67-78 (2011) Angiogenesis 15: 131-139 (2012).

3.972

Med. Law J. 31:119-152 (2012).

J. Med. Ethics 38: 474-478 (2012).

1.419

Stem Cell Rev. Rep. 8: 1066-1075 (2012).

4.523

Innovation: Management, Policy and Practice 15: 207-216 (2013). BMC Med. Genet. 14:20 (2013).

2.536

- 36 -

118 Mahomed S., Slabbert M.N. and Pepper M.S. 119 Nielsen S.R., Hammer T., Gibson J., Pepper M.S., Nisato R.E., Dissing S. and Tritsaris K. 120 Barmania F., Potgieter M. and Pepper M.S. 121 Meissner-Roloff and Pepper M.S.

122 Grant C.C., Janse van Rensburg D.C., Pepper M.S., du Toit P.J., Wood P.S., Ker J., Krüger P.E., Grobbelaar C.W., Nolte K., Fletcher L. and Grant T.C. 123 Mabeta P. and Pepper M.S.

124 Mellet J., Alessandrini M., Steel H.C and Pepper M.S. 125 Taylor J., Anyango J.O., Potgieter M., Kallmeyer K., Naidoo V., Pepper M.S and Taylor J.R.N.

The legal position of the classification of human tissue in South Africa – can tissues be owned? IL-27 inhibits lymphatic endothelial cell proliferation by STAT1-regulated gene expression.

S. Afr. J. Bioethics Law Microcirculation 20: 555-564 (2013).

2.736

Mutations in C-C chemokine receptor type five (CCR5) in South African individuals. Establishing a public umbilical cord blood stem cell bank (UCB SCB) for South Africa: an enquiry into public acceptability.

Int. J. Infect. Dis. 17: e1148–e1153 (2013). Stem Cell Rev. Rep. 9: 752–763 (2013).

2.357

The correlation between the healthrelated fitness of healthy participants measured at home opposed to fitness measured by sport scientists in a laboratory. Altered expression of platelet factor 4 and basic fibroblast growth factor correlates with the inhibition of tumor growth in mice. Constituting a public umbilical cord blood bank in South Africa.

S. Afr. Family Practice. 56: 235-239 (2014).

Biocompatibility and biodegradation of protein microparticle and film scaffolds made from kafirin (sorghum prolamin protein) subcutaneously implanted in rodent models.

6: 16-20 (2013).

4.523

Biomedicine & Pharmacotherapy 69: 186-190 (2015). Bone Marrow Transplantation. In press (2015). Journal of Biomedical Materials Research: Part A. In press (2015).

Review Articles and Editorials Total impact factor: 266.52 Number of publications: 53 (12 without IF) Mean impact factor per article: 6.50 (As of June 2014)

No.

Authors

Title

Journal

1

Pepper M.S.

2

Montesano R., Pepper M. and Orci L.

S. Afr. Med. J. 66: 883-888 (1984). News Physiol. Sci. 5: 75-79 (1990).

3

Pepper M.S. and Montesano R.

Dance - a suitable form of exercise? A physiological appraisal. Angiogenesis in vitro: morphogenetic and invasive properties of endothelial cells. Proteolytic balance and capillary morphogenesis.

4

Vassalli J.-D. and Pepper M.S.

Tumor biology: membrane proteases in focus.

Nature 370: 14-15 (1994).

Impact Factor 1.702 6.750

Cell Diff. Dev. 32: 319-328 (1990). 38.597

- 37 -

5

8

Fotsis T., Pepper M., Aldercreutz H., Hase T., Montesano R. and Schweigerer L. Pepper M.S., Mandriota S.J., Vassalli J.-D., Orci L. and Montesano R. Pepper M.S., Montesano R., Mandriota S.J., Orci L. and Vassalli J.-D. Pepper M.S.

9

Pepper M.S.

10

Pepper M.S.

11

Montesano R., Soriano J.V., Pepper M.S. and Orci L. Soriano J.V., Pepper M.S., Orci L. and Montesano R.

6

7

12

13

14

Fotsis T., Pepper M.S., Montesano R., Aktas E., Breit S., Schweigerer L., Rasku S., Wahala K. and Adlercreutz H. Mandriota S.J. and Pepper M.S.

Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis.

J. Nutr. 125: 790S-797S (1995).

4.196

Angiogenesis regulating cytokines: activities and interactions.

Curr. Top. Microbiol. 213/II: 31-67 (1996). Enzyme Protein 49: 138-162 (1996).

4.860

Vasc. Med. 1: 259-266 (1996).

1.617

Cytokine Growth F. R. 8: 21-43(1997). Arterioscl. Thromb. Vasc. Biol. 17: 605619 (1997). J. Cell. Physiol. 173: 152-161 (1997).

8.831

Roles of hepatocyte growth factor/scatter factor and transforming growth factor-1 in mammary gland ductal morphogenesis. Phytoestrogens and inhibition of angiogenesis.

J. Mammary Gland Biol. Neoplasia 3: 133-150 (1998).

7.524

Lymphangiogenèse et activité biologique du facteur de croissance vasculaire endothéliale-C. Angiogenèse et morphogenèse de l‟arbre vasculaire: de la biologie cellulaire à la clinique.

J. Soc. Biol. 193: 159-163 (1999).

Lymphangiogenesis and tumor metastasis: more questions than answers. Lymphangiogenesis and tumor metastasis: myth or reality? Lymphangiogenesis and lymphatic microdissemination. Extracellular proteolysis and angiogenesis.

Lymphology 33: 144-147 (2000). Clin. Cancer Res. 7: 462-468 (2001). Gynecol. Oncol. 82: 1-3 (2001). Thromb. Haemostasis 86: 346-355 (2001). Arterioscl. Thromb. Vasc. Biol. 21: 1104-1117 (2001). Lancet Oncol. 3: 44-52 (2002). Nat. Rev. Mol. Cell Biol. 3: 133-137 (2002).

Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis. Positive and negative regulation of angiogenesis: from cell biology to the clinic. Transforming growth factor-beta: vasculogenesis, angiogenesis and vessel wall integrity. Manipulating angiogenesis: from basic science to the bedside. Induction of epithelial branching tubulogenesis in vitro.

15

Pepper M.S.

16

Pepper M.S.

17

Pepper M.S.

18 19

Van Trappen P.O. and Pepper M.S. Pepper M.S.

20

Pepper M.S.

Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis.

21

Van Trappen P.O. and Pepper M.S. Orci L. and Pepper M.S.

Lymphatic dissemination of tumor cells and the formation of micrometastases. Microscopy: an art?

22

6.338

4.218

Baillieres Clin. Endocrinol. Metab. 12: 649-666 (1998).

Médecine Sciences 12: 1378-1386 (2000). 1.190 7.837 3.929 6.094

6.338

25.117 37.162

- 38 -

23

Nisato R.E., Tille J.-C. and Pepper M.S.

Lymphangiogenesis and tumor metastasis.

24

Pepper M.S. and Skobe M. Pepper M.S., Tille J.-C., Nisato R. and Skobe M. Tille J.-C. and Pepper M.S.

Lymphatic endothelium: morphological, molecular and functional properties. Lymphangiogenesis and tumor metastasis. Hereditary vascular anomalies: new insights into their pathogenesis.

27

Pathak A.P., Bhujwalla Z.M. and Pepper M.S.

Visualizing function in the tumorassociated lymphatic system.

28

Pepper M.S.

29

Van Trappen P.O. and Pepper M.S. van der Merwe M.T. and Pepper M.S. Van der Auwera I., Cao Y., Tille J.C., Pepper M.S., Detmar M., Jackson D.G., Fox S.B., Harris A.L., Dirix L.Y., Vermeulen P.B. Pepper M.S. and van der Merwe M.T.

Polymorphisms in the endothelial nitric oxide synthase gene and the tendency for aneurysm rupture. Lymphangiogenesis in human gynaecological cancers. Obesity in South Africa.

25 26

30 31

32

33

34

Pathak A.P., Hochfeld W.E., Goodman S.L. and Pepper M.S. Pepper M.S.

35

Logan M.G. and Pepper M.S.

36

Pepper M.S.

37

Pepper M.S.

38

Mabeta P. and Pepper M.S. Slabbert M.N. and Pepper M.S.

39

40

Pepper M.S.

41

Warnich L., Drögemöller B.I., Pepper M.S., Dandara C and Wright G.E.B. Myburgh R., Hochfeld W.E., Dodgen T.M., Ker

42

First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours.

The genetics of obesity.

Circulating and imaging markers for angiogenesis. The stem cell regulatory environment in South Africa: cause for concern. The genetics of obesity: the role of the melanocortin 4 receptor.

Thromb. Haemostasis 90: 591-597 (2003). J. Cell Biol. 163: 209-213 (2003). Cell Tissue Res. 314: 167-177 (2003). Arterioscl. Thromb. Vasc. Biol. 24: 1578-1590 (2004). Lymphatic Res. Biol. 2: 165-172 (2004). J. Neurosurg. 102: 433 (2005).

6.094

Angiogenesis 8: 137-145 (2005). Obesity Rev. 7: 315322 (2006). Brit. J. Cancer 95: 1621-1625 (2006).

3.972

S. Afr. Cardiol. Stroke J. Spring: 48,50 (2007). Angiogenesis 11: 321-325 (2008).

S. Afr. Med. J. 99: 505-507 (2009). J. Endocrinol. Metab. Diabetes S. Afr. 15: 45-47 (2010). Cell-based therapies: navigating troubled S. Afr. Med. J. waters. 100: 34-35 (2010). The human genome and molecular S. Afr. Med. J. medicine: promises and pitfalls. 100:722-724 (2010). Hemangiomas: current therapeutic Int. J. Dev. Biol. strategies. 55: 431-437 (2011). No-fault liability of health care S. Afr. Med. J. providers in therms of the Consumer 101: 800-801 (2011). Protection Act. Launch of the Southern African Human S. Afr. Med. J. Genome Programme. 101: 287-288 (2011) Pharmacogenomic research in South Curr. Africa: lessons learned and future Pharmacogenomics opportunities in the rainbow nation. Personalized Med. 9: 191-207 (2011). Cardiovascular pharmacogenetics. Pharmacol. Therapeut.

10.822 3.677 6.338

2.333

3.148

6.870 5.082

3.972

1.702

1.702 1.702 2.614 1.702

1.702

7.793

- 39 -

43

J. and Pepper M.S. Meissner-Roloff M. and Pepper M.S.

44

Pepper M.S.

45

Pepper M.S.

46

Potgieter M., Pretorius E. and Pepper M.S.

47

Jackson C. and Pepper M.S.

48

Barash C.I. and Pepper M.S.

49

Barmania F. and Pepper M.S.

50

Meissner-Roloff M. and Pepper M.S.

51

Alessandrini M., Asfaha S.M., Dodgen T.M., Warnich L. and Pepper M.S.

CYP450 pharmacogenetics in African populations.

52

Ali A.T., Hochfeld W.E. Myburgh R. and Pepper M.S.

53

Alessandrini M. and Pepper M.S.

54

Čolić A., Alessandrini M. and Pepper M.S.

55

56

Stem cell research engenders interdisciplinary collaboration in science, ethics and religion. Partial relief from the regulatory vacuum involving human tissues through enactment of Chapter 8 of the National Health Act and regulations thereto. Enactment of Chapter 8 of the National Health Act and regulations thereto. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Opportunities and barriers to establishing a cell therapy programme in South Africa. Editorial: Special issue pharmacogenomics & personalized medicine. C-C chemokine receptor-5 (CCR5): an emerging target for the control of HIV infection. Curbing stem cell tourism in South Africa.

133: 280-290 (2012). S. Afr. J. Sci. 108: 5-6 (2012). S. Afr. Med. J. 102: 736-737 (2012).

S. Afr. J. Bioethics Law. 5: 60 (2012). J. Nutrition 71: 180-188 (2013).

0.835

1.702

4.196

Stem Cell Res. Ther. 4 : 54 (2013). Appl. Translational Genomics. 2: 1-2 (2013). Appl. Translational Genomics. 2: 3-16 (2013). Appl. Translational Genomics. 2: 22-27 (2013). Drug Metab. Rev. 45: 253-75 (2013).

3.652

Adipocyte and adipogenesis.

Eur. J. Cell Biol. 92:229-236 (2013).

3.213

Pharmacogenomics 15:385-400 (2014)

3.857

Kallmeyer K. and Pepper M.S.

Priority pharmacogenetics for the African continent: focus on cytochrome P450. Pharmacogenetics of CYP2B6, CYP2A6, and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine. Homing properties of mesenchymal stromal cells.

Atashi F., ModarressiGhavami A. and Pepper M.S.

The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation : a review.

5.538

Drug Metabolism Rev. In press (2015) Expert Opinion on Biological Therapy. In press (2015) Stem Cells and Development. In Press (2015)

Chapters in Books

No. 1

Authors Montesano R., Pepper M.S.,

Chapter Title The control of angiogenesis: endothelial cell-matrix interactions and extracellular

Book Ref In Pathophysiology of pulmonary cells. Endothelial and mucus

- 40 -

Vassalli J.-D. and Orci L.

proteolysis. In Pathophysiology of pulmonary cells. Endothelial and mucus producing cells. Modulation of angiogenesis in vitro.

2

Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.

3

Pepper M.S., Vassalli J.-D., Orci L. and Montesano R.

Proteolytic balance and capillary morphogenesis in vitro.

4

Montesano R., Vassalli J.-D., Orci L. and Pepper M.S.

The role of growth factors and extracellular matrix in angiogenesis and epithelial morphogenesis.

5

Pepper M.S., Vassalli J.-D., Orci L. and Montesano R.

Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.

6

Fotsis T., Pepper M.S., Aktas E., Joussen A., Kruse F., Adlercreutz H., Wähälä K., Hase T., Montesano R. and Schweigerer L. Pepper M.S., Tacchini-Cottier F., Sabapathy K., Montesano R. and Wagner E.F. Montesano R. and Pepper M.S.

Inhibitors of angiogenesis in human urine.

9

Pepper M.S. and Saurat J.-H.

Eléments d‟angiogenèse cutanée.

10

Pepper M.S.

Angiogenesis and vascular morphogenesis.

11

Montesano R. and Pepper M.S.:

Capillary morphogenesis in vitro: cytokine interactions and balanced proteolysis.

7

8

producing cells. A. Junod, D. Olivieri and E. Pozzi, Eds. Masson Italia Periodici (Milan): 1-17, 1991. In Angiogenesis: key principles, science, technology, medicine. P.B. Weisz, R. Langer and R. Steiner, Eds. Birkhäuser Verlag (Basel): 129-136, 1992. In Angiogenesis: key principles, science, technology, medicine. P.B. Weisz, R. Langer and R. Steiner, Eds. Birkhäuser Verlag (Basel): 137-145, 1992. In Frontiers in endocrinology. Volume 6: Developmental endocrinology. P.C. Sizonenko, M.L. Aubert and J.-D. Vassalli, Eds. AresSerono Symposia Publications (Rome): 43-66, 1994. In Angiogenesis: molecular biology, clinical aspects. M.E. Maragoudakis, P.M. Gullino and P.I. Lelkes, eds. Plenum Press (New York): 149-170, 1994. In Molecular, cellular and clinical aspects of angiogenesis. M.E. Maragoudakis, Ed. Plenum Press (New York): 213-227, 1996.

Endothelial cells transformed by polyomavirus middle T oncogene: a model for hemangiomas and other vascular tumours.

In Tumour angiogenesis. R. Bicknell, C.E. Lewis and N. Ferrara, Eds. Oxford University Press (Oxford): 309-331, 1997.

Three-dimensional in vitro assay of endothelial cell invasion and capillary tube morphogenesis.

In: Vascular morphogenesis: in vivo, in vitro, in mente. C.D. Little, V. Mironov and H. Sage, Eds. Birkhäuser Boston (Cambridge, MA): 79-110, 1998. In: Dermatologie et maladies sexuellement transmissibles, 3ème édition. J.-H. Saurat, E. Grosshans, P. Laugier, J.-M. Lachapelle, Eds. Masson (Paris): 626-627, 1999. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice. R.W. Colman, J. Hirsh, V.J. Marder, A.W. Clowes and J.N. George, Eds. Lippincott-Raven Publishers (Philadelphia): 771-779, 2001. In: Tumor angiogenesis and microcirculation. E.E. Voest and P.A. D'Amore, Eds. Marcel Dekker Inc.

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12

Iruela-Arispe M.L., Ortega M.A., Oikemus S. and Pepper M.S.

Vascular morphogenesis the mammary gland – introduction and overview.

13

Saaristo A., Karkkainen M.J., Alitalo K., Montesano R., Iruela-Arispe M.-L. and Pepper M.S.

Growth factor regulation of physiological angiogenesis in the mammary gland.

14

Pepper M.S., Mandriota S.J. and Montesano R.: Pepper M.S.

Angiogenesis-regulating cytokines.

16

Tille J.-C., Nisato R. and Pepper M.S.

17

Pepper M.S. and Saurat J.-H.

Lymphangiogenesis and tumour metastasis. Novartis Foundation Symposium 256: Cancer and Inflammation. Eléments d‟angiogenèse cutanée.

18

van der Merwe M.T. and Pepper M.S.

Energy conservation during evolution: the impact on obesity, a modern epidemic.

19

Pepper M.S.

The lymphatic system.

20

Harrison J.A., Buser R. and Pepper M.S.

Angiogenesis, lymphangiogenesis and vascular morphogenesis.

21

Pepper M.S. and Lolas G.

The lymphatic vascular system in lymphangiogenesis, invasion and metastasis: a mathematical approach.

15

Role of the plasminogen activatorplasmin system in angiogenesis.

(New York): 111-141, 2001. In: Vascular Morphogenesis in the Female Reproductive System. Cardiovascular Molecular Morphogenesis Series. H.G. Augustin, M.-L. Iruela-Arispe, P.A.W. Rogers and S.K. Smith, Eds. Birkhäuser (Boston): 3-24, 2001. In: Vascular Morphogenesis in the Female Reproductive System. Cardiovascular Molecular Morphogenesis Series. H.G. Augustin, M.-L. Iruela-Arispe, P.A.W. Rogers and S.K. Smith, Eds. Birkhäuser (Boston): 25-40, 2001. In: The New Angiotherapy. T.-P. Fan and E.C. Kohn, Eds. Humana Press Inc. (Totowa, NJ): 7-40, 2002. In: Plasminogen: structure, activation and regulation. D.M. Waisman, Ed. Kluwer Academic/Plenum Publishers (New York): 269-290, 2003. John Wiley and Sons Ltd (Chichister, UK): 112-136, 2004.

In: Dermatologie et infections sexuellement transmissibles, 4ème édition. J.-H. Saurat, E. Grosshans, P. Laugier, J.-M. Lachapelle, Eds. Masson (Paris): 694-695, 2004. In: Voyages in Science. Essays by South African anatomists in honour of Philip V. Tobias‟ 80th birthday. G. Strkalj, N. Pather and B. Kramer, Eds. Content Solutions (Pretoria): 141-157, 2005. In: Encyclopedia of the Microvasculature. D. Shepro, Ed. Elsevier Inc. (San Diego): 523-527, 2005. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice. 5th edition. R.W. Colman, V.J. Marder, A.W. Clowes, J.N. George and S.Z. Goldhaber Eds. Lippincott Williams and Williams (Philadelphia): 679-689, 2005. In: Selected topics in cancer modeling: genesis, evolution, immune competition, and therapy. N. Bellomo, M. Chaplain, and E. De Angelis Eds. Series: Modelling and Simulation in Science, Engineering and Technology. Birkhauser (Boston, MA). 255-276, 2008.

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22

Durandt C., Asfaha S.M. and Pepper M.S.

Pharmacogenetics.

23

Nisato R.E., Buser R. and Pepper M.S.

Lymphatic endothelial cells: establishment of primaries and characterization of established lines.

24

Pepper M.S. and Saurat J.-H.

Eléments d‟angiogenèse cutanée.

25

Hochfeld W.E, Asfaha S.M., Alessandrini M., Dodgen T.M., Myburgh M., Eloff A. and Pepper M.S.

Pharmacogenetics and pharmacogenomics in the developing world.

In: Molecular Medicine for Clinicians. B. Mendelow, M. Ramsay, N. Chetty and W. Stevens Eds. Wits University Press (Johannesburg). 433-437, 2009. In: Methods in Molecular Medicine 467: Angiogenesis Protocols 2nd edition. S. Martin and C. Murray Eds. Humana Press Inc. (New York, NY). 113-126, 2009. In: Dermatologie et infections sexuellement transmissibles, 5ème édition. J.-H. Saurat, J.-M. Lachapelle, D. Lipsker, L. Thomas, Eds. Masson (Paris): 698-699, 2009. In: Genomics and Health in the Developing World. D. Kumar Ed. Oxford University Press (New York): 168-191, 2011.

Patents Patent full title: Stimulation, modulation and/or inhibition of endothelial proteolytic activity and/or angiogenic activity Patent number: WO 1999008522 A1 This is a utility patent Description of patent: Vascular endothelial growth factor-B (VEGF-B) and vascular endothelial growth factorC (VEGF-C) are angiogenic polypeptides. It has been shown that VEGF-B and -C are angiogenic in vitro especially in combination with bFGF. VEGF-C also increases plasminogen activator (PA) activity in bovine endothelial cell lines and this is accompanied by a concomitant increase in PA inhibitor-1. Addition of alpha-2antiplasmin to bovine endothelial cells co-treated with bFGF and VEGF-C partially inhibits collagen gel invasion. Patent Assignee: Ludwig Inst Cancer Res; Univ Helsinki Licensing; Univ Geneva Inventors: Pepper M.S., Alitalo K., Eriksson U. Web address: http://www.google.com/patents/WO1999008522A1?cl=en Own contribution: Responsible for the key findings, namely synergism between antiogenic cytokines, and stimulation of angiogenic and proteolytic activity by these cytokines in vitro Patent full title: Methods and compositions for directing migration of neural progenitor cells Patent number: US 2008/0118480 A1 This is a utility patent Description of patent: Method for modulating the migration of neural progenitor cells in a mammal by exposing the cells to a VEGFR-2 ligand and FGF-2. Methods of treating neurological disorders by exposing the mammal to a VEGFR-2 ligand in the presence of FGF-2 are also provided. A composition including a biocompatible matrix associated with FGF-2 is also provided. Patent assignee: Imclone Systems Incorporated New York NY, USA Inventors: Zhang H., Vutsikas L., Pepper M.S., Kiss J.Z. Web address: http://www.google.com/patents/US20080118480 Own contribution: Invloved in the conceptualization and execution of the experiments leading to the key findings

- 43 -

Patent full title: Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids Patent number: WO 1997045143 A1 This is a utility patent Description of patent: This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on the role of their signaling pathway in endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagged protein, as well as a substantially purified nucleic acid molecule or segment thereof encoding Jagged protein, or a functionally equivalent derivative, or allelic or species variant thereof. Patent assignee: Thomas Maciag, Roberto Montesano, Nat American Red Cross; Michael S. Pepper, Univ Geneve Michael K K Wong, Ann B Zimrin Inventors: Maciag T., Montesano R., Pepper M.S., Wong M.K.K., Zimrin A.B. Web address: http://www.google.com/patents/WO1997045143A1?cl=en Own contribution: Invloved in the conceptualization and execution of the experiments leading to the key findings Patent full title: Transgenic cell selection Patent number: PCT PATENT: PCT/US2014/019308 (based on US Provisional Application 61/771,331) This is a utility patent Description of patent: The invention relates generally to the field of molecular biology and medicine. More particularly, it concerns methods for production and selection of transgenic cells and vectors for the production of such cells. Inventors: Krause K.H., Suter D., Salmon P., Myburgh R., Pepper M.S. Web address: application not published yet; anticipated publication date: Jan 2015 Own contribution: Co-initiator of the HIV gene therapy project.

Technical/policy reports 1. Pepper M.S., Ramburan V.P. and Lamprecht S. Report on the BioSA / COFISA Intervention aimed at facilitating South African and Finnish business-to-business collaboration in the Biotechnology and Life Science sectors. May 2008. (56 pages) 2. Alessandrini M., Barnett J., Klose K., Pepper M.S. and van der Bijl P.Understanding Technology Transfer at higher education institutes (HEIs): A South African study. World Bank Institute. June 2010. (120 pages) 3. SAHGP Core Group (Bardien S., Christoffels A., Mphahlele J., Pepper M.S., Ramesar R., Ramsay M., Rees J., Soodyall H., Venter P. and Warnich L), Napier H. and SAHGP writing groups. Southern African Human Genome Programme. Report to the Dept. of Science and Technology, July 2011. (87 pages)

Position statements 4. National Biotechnology Advisory Committee (NBAC). Position statement on Stem Cell Regulations in South Africa. 2008. (Authored by Pepper M.S.) 5. National Biotechnology Advisory Committee (NBAC). Position statement on Genomic Sovereignty in South Africa. 2011. (Authored by Pepper M.S. and Slabbert M.N.) 6. South African Society of Obstetrics and Gynaecology (SASOG). Position statement on umbilical cord blood banking. Soma-Pillay P. and Pepper M.S. 17 March 2014. http://www.sasog.co.za/images/Umbilical_cord_blood_banking_March2014.pdf

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Other Publications 1.

Pepper M.S.: An approach to the injured dancer. Arabesque 21: pages 11,13,41, 1983.

2.

Pepper M.S.: Understanding the injured dancer. S. Afr. J. Sports Med. 24: 9-13, 1984.

3.

Kern P., Calza A.-M., Pittet-Cuenod B., Pepper M.S., Benador D., Lecoultre C., Rüfenacht D. and Bounameaux H.: Hémangiomes et malformations vasculaires: casuistique d'une consultation multidisciplinaire. Médecine et Hygiène 55: 118-123, 1997.

4.

Hansson G., Carmeliet P. and Pepper M.: Tribute to Werner Risau: December 18, 1953-December 13, 1998. Arterioscl. Thromb. Vasc. Biol. 19: 829, 1999.

5.

Pepper M.S. Lymphangiogenesis and tumor metastasis. Swiss Cancer Bulletin 21: 122-124, 2001.

6.

Pepper M.S. Literature Watch – Summary and perspectives. Lymphatic Res. Biol. 1: 245-246, 2003.

7.

Molecular and Metabolic Medicine Update newsletter. http://www.ampath.co.za/news.htm

Year 2006

2007

2008

2009

Vol 2 2 2 2 3 3 3 3 3

No 3 4 4 5 2 2 3 4 4

Author Pepper van der Merwe and Pepper Pepper and Naude Pepper and Durandt Naude, Watermeyer and Pepper Pepper Pepper and Jordaan Pepper, Gould and Crookes Pepper

4 4

1 2

Pepper Pepper

4

3

Marrs, Pepper

4 4

4 5

Pepper Pepper, Krause, Stoltz, Sorce

4 4

5 6

Pepper Pepper, Pathak

5

2

Pepper

Title Stem cell therapy The genetics of obesity Blood conservation in South Africa Pharmacogenetics The transfusion trigger Controversial issues in the stem cell arena Cell-based therapy in South Africa Therapeutic plasma exchange A model for the co-existence of public and private stem cell banks Pharmacogenetics – where are we today? Omega fatty acids -3, -6 and -9. Unraveling the mystery Peripheral blood stem cells for bone marrow transplantation Blood conservation Rendering the immune system resistant to HIV – a potential therapeutic strategy? Induced pluripotent stem cells A need for novel surrogate markers of angiogenesis The stem cell regulatory environment in South Africa

8.

Report: Bioethics Forum on Stem Cell Banking, held at the Innovation Hub, Pretoria, on 15 June 2007. Compiled by: Dominique Schaub, Stephen Marrs, Doretha Thompson, Michael Pepper, Donrich Jordaan. 23 July 2007.

9.

CIPS e-briefs. July / August 2007. www.policystudies.up.ac.za  Cell-based therapy and the biotech sector in South Africa by Dr David Keetch, Prof Michael Pepper and Prof Jocelyn Webster.  A model for the co-existence of public and private stem cell banks by Prof Michael Pepper.  Banning private umbilical cord blood banks - a human rights analysis by Adv Donrich Jordaan, Prof Michael Pepper, Adv Christopher Woodrow and Adv Naude de Wet.

- 45 -

10. Report: The Human Tissue Regulatory Environment, held at the Innovation Hub, Pretoria, on 27 May 2009. Compiled by: Michael Pepper. July 2009. 11. Pepper M.S. Regaining perspective on stem cells. S. Afr. Family Practice 52: 164, 2010. 12. Pepper M.S. The healing power of stem cells: why we need rules. S. Afr. Family Practice 52: 365, 2010. 13. Article series in Rolling Inspiration:  Pepper. M.S. Stem cell, hard sell (September/October 2009)  Pepper. M.S. Regaining perspective on stem cells (January/February 2010)  Pepper. M.S. The healing power of stem cells: why we need rules (March/April 2010)  Pepper. M.S. We are what we eat (July/August 2010)  Pepper. M.S. The importance of keeping accurate records (September/October 2010)  Potgieter M. and Pepper M.S. Stem cell therapy: 8 things to consider at decision making crunch time (January/February 2011)  Potgieter M. and Pepper M.S. Stem cell therapy for neuromuscular disorders (September/October 2011). 14. Article series in the Muscular Dystrophy Foundation Magazine:  Pepper. M.S. Stem cell, hard sell (Vol 32, pages 18-19, August, 2010)  Pepper. M.S. Regaining perspective on stem cells (Vol. 33, pages 20-21, December 2010)  Pepper. M.S. The healing power of stem cells: why we need rules (Vol. 34, pages 28-29, April 2011)  Potgieter M. and Pepper M.S. Stem cell therapy for neuromuscular disorders (Vol. 35, pages 26-27, August 2011).

Web-based programme on stem cells http://www.in3sixty.com/education/20110110_PUB/internet/lowres/pub_intro.html http://www.in3sixty.com/education/20110110_PUB/internet/lowres/pub_stemcells_lab1.htm

Interactions with the Media Entity

Date

Title

Comment

IOL Lifestyle

2014, 17 February

By: Lali van Zuydam

Pretoria News

2014, 12 February

Business Day

2014, 14 January

Mail and Guardian

2013, 18 October

Mail and Guardian

2013, 11 October

Business Day

2013, 06 June

Sunday Times

2013, 19 May

Being gay is no conscious decision expert Being gay is no conscious decision, says expert Proposed R2bn fund aims to boost bio-economy Baby, make those genes talk SA lights a torch in the genomic revolution Researchers seek clarity on human tissue rights Mapping the Unique Genes of Southern

Printed and e-media

By: Lali van Zuydam

By: Tamar Kahn

By: Sarah Wild By: Sarah Wild By: Tamar Kahn

By: Bobby Jordan

- 46 -

Mail and Guardian

2013, 17 May

Beeld

2013, 07 March

Izindaba, South African Medical Journal Beeld

2013, January; 103(1): 8-9

Africa Now the beauty of stem cells is only skin deep Stamselbehandeling “is die risiko werd” „Pioneer‟ Paarl neuro sets alarm bells ringing

2012, 28 December

Etiek van Stamselle

By: Antoinette Pienaar

Beeld

2012, 28 November

By: Elzabé Brits

Die Burger

2012, 28 November

Die Burger

2012, 27 November

Beeld

2012, 26 November

The Times

2012, 26 October

Sunday Times

2012, 22 July

City Press

2012, 8 July

Rapport

2012, 8 July

Business Day

2012, 13 January

Die Burger

2011, 19 September

Business Day

2011, 19 September

The Centurion

2011, September

Business LIVE

2011, 15 September

Medical Chronicle

2011, June

Biotechnology – Executive Education Business Day

2010, 7 December

Medical Chronicle

2010, October

Medical Chronicle

2010, August

The Mercury

2010, 1 June

Stamselle: etiese komitee moes kyk Etiese komitee „is nie betrek‟ Kenners besorgd oor behandeling Geen bewys dat dit werk Unborn kids „hold key to life‟ Doctors are „sick and tired‟ Doctors lose patience as suits spike Hof toe met jou, dokter ! Diverse SA must tap stem cells locally Stamselle van naelstringe nou in SA bewaar Venture lifts hope for stem cell progress The next major wave of commercial activity – Bio-entrepreneurship Stem cell storage divides SA human genome project will benefit local society Bio-entrepreneurs, a new breed in business Research into genetic variation should help disease prevention Doing good work against great odds: the challenges faced in stem cell transplants Bloodless medicine: techniques used to reduce the use of blood and its components Clarity on stem cells

By: Sarah Wild

By: Antoinette Pienaar By: Chris Bateman

By: Elzabé Brits By: Elzabé Brits By: Elzabé Brits By: Katharine Child By: Bobby Jordan By: Eugene Botha By: Eugene Botha By: Sarah Wild By: Elsabe Brits

By: Sarah Wild

By: Nashira Davids

By: Tamar Kahn

By: Omeshnie Naidoo

- 47 -

Business Day

2010, 18 February

The Mercury

2009, November

Medical Chronicle

2009, November

Health 24

2009, 23 September

Health 24

2009, 11 August

Financial Mail

2009, 7 August

Weekend Argus

2009, 24 May

FIT Pregnancy

2009, February/March 33-34

Medical Chronicle

2008, July

Vrouekeur

2008, 28 March

Pretoria News

2007, 20 September

Mail & Guardian – Online

2007, 14 September

The Citizen

2007, 13 September

Mail & Gaurdian – Online Netcare – Media Release

2007, 13 September

Rekord Oos/East (Local Paper) The Argus

2007; 30 March

Die Burger

2007, September

Medical Chronicle

2006, October

Rapport

2006, 3 September

Netcare – Media Release

2006, 14 August

2007, 12 September

2007, September

Tutu gives his genes to science Beware of bogus stem cell therapies: expert warns Public stem cell bank to move SA into the future of medical research Stem cell research: where it is at Stem cells – hope or hype Past cell-by date

By: Tamar Kahn

Acute need for public stem cell bank in SA Mom‟s the word – Where to we come from? Bloodless programmes address global blood shortage Boustene van „n nuwe lewe Scientist strive to stop pending clampdown on stem cell research Netcare makes investment in stem cell development Call for support of blood conservation projects Call to support bloodconservation projects Netcare calls on healthcare professionals and SA public to support blood conservation Stem cells can now be stored for later use New law will kill stem cell industry – experts Kenner maak sterk kapsie oor stamselwet Blood conservation in South Africa „Ek sal alles probeer‟ – Stemsel-terapie bring hoop, al sê medici wát Cutting edge institute launched for cellular and molecular medicine

By: Melanie Peters

By: Omeshnie Naidoo

By: Carine Visagie

By: Razina Munshi

By: Lisa Morris

By: Tanya de Vente By: Di Caelers

By: Martina Nicholson

By: Petro van Rensburg By: Di Caelers By: Elsabe Brits

By: Marenet Jordaan

By: Martina Nicholson

- 48 -

Rapport

2006, 13 Augustus

Medical Chronicle

2006, 8 August

Mail & Guardian

2006, 4 August

Insurance gateway – Online

2006, 20 July

Business iafrica – Online Medical Chronicle

2006, 19 July

Financial Mail

2006, 5 May

Netcells – Netcare

2006, May

Netcare – Media Release

2006, 4 April

Rapport

2006, 5 February

South African Medical Journal Financial Mail Financial Mail The Scientist 17: 33-34

2005, January 2004, 17 December 2004, 1 July 2003

Netcare makes substantial investment in stem cell development Netcare invests in stem cells Stem cell storage: Insurance against future disease The ultimate wash cycle Umbilical cord blood stem cell storage Netcare‟s blood conservation institute to address dire blood shortage in SA Etiekraad gee groen lig vir harttegniek Pharmacogenetics offers hope Genes can reduce costs Race for a Cure Cancer‟s other conduit

Méditorial

2000, 23 October

Sur les pas de….

CAP Today

2000, May

Reuters Health

2000, 21 January

L‟illustré 41: 66-67

1999, 13 October

Bio World International

1997, 4 June

Le Temps

1998, 12 May

GHI

1994, 24 March

Le Nouveau Quotidien

1994, 18 March

Cytokines‟ steady march to labs High plasma level of angiogenic cytokines may help in diagnosis of cancer Demain le pontage sera biologique Finnish researcher uncover mechanisms that cause growth of endothelial cells – Lymph Vaincre le cancer, c‟est lui couper les vivres Cancer: nouvelle piste á Genéve Asphyzier et affamer les tumeurs. Voie prometteuse de reserche sur le cancer

2006, July

Regering moet ongesonde kos belas, sê medikus Umbilical cord blood stem cell therapy harmed by misinformation Soft sell on stem cells

By: Marenet Jordaan

By: Belinda Beresford

By: Claire Bisseker By: Kim Long By: Martina Nicholson

By: Elise-Marie Tancred By: Chris Bateman By: Peter Honey By: Jacqui Pile By: Scientist staff (Steve Bunk) By: Karin Titus By: Pam Harrison

By: Sharon Kingman

By: Anne Crisinel

By: Anne Crisinel

- 49 -

Symptômes

1994, p22

Nouvelle substance

New in Physical Science

1990, December; Vol 5, 272-273

SAMEDI Litteraire

1990, 10 November

New capillaries make their way by tightly regulated extracellular proteolysis Bienfaits et méfaits de l‟angiogenése

Television SABC 3

2014, 19 October

Stem cells

Interviewer: Lindile Mpanza Interviewer: Sipho Stuurman

SABC 3

2014, 04 August

Stem cells

TVJ (TV Jamaica): Smile Jamaica Kyknet: Nege maande Dagbreek (eNews) eTV (eNews)

2013, 21 November

Stem cells

2013, 8 August 2013, 19 March 2012, 13 July

Stem cells Stem cells Medical Malpractice Litigation

SABC Current Affairs Summit TV

2009, 10 July 2009, 13 February

Stem cell problems

SABC2 Weekend Live

2008, 22 November

Netcare TV: Matters Medical

2008, 5 February

Netcare TV: Matters Medical Netcare TV: Matters Medical Netcare TV: Matters Medical Netcare TV: Matters Medical SABC3

2007, 6 November

Human interest issues, the arts, lifestyle and entertainment Therapeutic Applications of Stem Cells Blood conservation

2007, 7 August

Anaemia

(Chairperson)

2007, 4 July

(Chairperson)

2007; 2 May

Hemochromatosis and Genetic Disorders Obesity

2007, 5 March

Stem cells

eTV – Great Expectations Emission Pulsations TV (Léman Bleue) Radio

2007, 20 February

Stem cell shortage

2002

Le sein dans tous ses etats

CII Radio SAFm HealthMatters on SAFm Smile94 FM

2014, 30 August 2014, 05 August 2014, 22 July

Stem Cells Stem Cells Stem Cells

2014, 15 July

Stem cells

Jamaican Nationwide Radio: This Morning Show Tuks FM

2013, 21 November

Stem cells

2013, 3 & 5 August

Radio Junto

2013, 28 May

Stem cells: the hype and the hope Stem cell research and

Presenter: Jane van Renen Presenter: Nastassja Tait

Interview with Karen Key Interview with Bobby Brown

Interview with

- 50 -

Radio Sonder Grense Monitor (news actuality program)

2012, 22 November

SAFM (repeated) as well as the Swazi and Ndebele stations Radio Sonder Grense Monitor (news actuality program)

2012, 1 November

Talk Radio 702 and 567 Cape Talk Talk Radio 702 and 567 Cape Talk Talk Radio 702 and 567 Cape Talk The Money Show SAfm radio

2012, 06 September

SAfm radio Science Matters East Coast Radio Midrand Community Radio Radio Sonder Grense Monitor (news actuality program)

2009, 17 September

2012, 25 October

2012, 12 July 2012, 09 July

2011, 03 May

therapy Treatment of spinal cord injuries using olfactory ensheathing cells Stem cells

Zwelibanzi Sisilana Interview with Metzi van der Merwe

Treatment of mitochondrial disorders using (pro)nuclear transfer Human Genome

Interview with Hanri Wondergrem

Medical Malpractice Litigation Medical Malpractice Litigation Stem Cells

2006, 11 August 2006, 24 May

Genetics of obesity Stem Cells

2005, 24 May

Beta sel groep oorplantings vir Diabetes 1: bekostigbaar?

Interview with Stephen Grootes Interview with Redi Thabi Interview with Bruce Whitfield Interview with Karen Key Interview with Christina Scott

Interviewer Marisa de Klerk

- 51 -

CONFERENCES, LECTURES AND SEMINARS (BY INVITATION)

1987 Sept.

EMBO workshop on Extracellular Matrix and Cell Differentiation. Santa Margherita Ligure, Genoa (Italy). Endothelial cell migration and extracellular proteolysis.

1990 Aug.

13th Sigrid Jusélius Symposium on Cell-Matrix Contacts and Pericellular Proteolysis. Helsinki (Finland). Proteolytic balance and capillary morphogenesis.

1991 Jan.

Swiss Institute for Experimental Cancer Research. Epalinges (Switzerland). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.

1991 Jan.

Jenkinson Lecturer, Department of Zoology and Sir William Dunn School of Pathology, Oxford University. Oxford (UK). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.

1991 March

International Symposium on Angiogenesis. St. Gallen (Switzerland). Proteolytic balance and capillary morphogenesis in vitro.

1991 June

XIème Forum de Cancerologie de la Société Française du Cancer et de la Fédération National des Centres de Lutte Contre le Cancer. Paris (France). Plenary lecture: Angiogenèse et Cancer.

1991 Sept.

International Society for Heart Research. 12th European Section Meeting. Leuven (Belgium). Proteolytic balance and capillary morphogenesis in vitro.

1991 Oct.

2nd Symposium on Growth, Differentiation and Pathology of Vascular Endothelium. Ringberg Castle (Germany). Angiogenesis in vitro: modulation of extracellular proteolysis and cell-extracellular matrix interactions.

1991 Nov.

Ciba-Geigy Limited. Basel (Switzerland). Proteolytic balance and capillary morphogenesis in vitro.

1992 June

11th International Congress on Fibrinolysis. Copenhagen (Denmark). Proteolytic balance and in vitro morphogenesis.

1992 Sept.

A New Understanding of the Role of Matrix Metalloproteinases in Tumor Biology, Upjohn Company/Brook Lodg. Kalamazoo (MI, USA). Proteolytic balance and morphogenesis of the microvasculature.

1992 Sept.

Department of Cell Biology, New York University Medical Center. New York (USA). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.

- 52 -

1992 Nov.

VIIth International Symposium on the Biology of Vascular Cells. San Diego (CA, USA). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.

1992 Nov.

Department of Pathology, University of Washington. Seattle (WA, USA). Angiogenesis in vitro: cytokine interactions and extracellular proteolysis.

1993 June

NATO Advanced Study Institute on Angiogenesis: Molecular Biology, Clinical Aspects. Rhodes (Greece). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.

1993 Nov.

Banbury Center conference on Mechanisms of Developmental and Tumor Angiogenesis, Cold Spring Harbor Laboratory. New York (USA). Angiogenesis in vitro: cytokine interactions and extracellular proteolysis.

1993 Nov.

Department of Pathology, Yale University. New Haven (CT, USA). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.

1993 Nov.

Swiss Connective Tissue Society Meeting. Geneva (Switzerland). Proteolytic balance and capillary morphogenesis in vitro.

1994 March

Union des Sociétés Suisses de Biologie Expérimentale. Bern (Switzerland). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.

1994 April

Growth Factor Club, Departement Forschung, Kantonsspital. Basel (Switzerland). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.

1994 April

Max-Planck-Arbeitsgruppen für Rheumatologie. Erlangen (Germany). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.

1994 April

Max-Planck-Institut für Physiologische und Klinische Forschung. Bad Nauheim (Germany). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.

1994 April

European Kidney Research Forum, Kloster Banz. Erlangen/Nürnberg (Germany). Plenary lecture: Regulation of angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.

1994 Aug.

VIIIth International Symposium on the Biology of Vascular Cells. Heidelberg (Germany). Angiogenesis in vitro: cytokine interactions and balanced proteolysis.

1994 Sept.

Max-Delbrück-Centrum für Molekulare Medizin, Franz-Volhard-Klinik.

- 53 -

Berlin-Buch (Germany). Angiogenesis. 1994 Sept.

Schering AG, Institute of Cellular and Molecular Biology. Berlin (Germany). Angiogenesis in vitro: mechanisms and modulators.

1994 Nov.

Swiss Society for Oncology. Bern (Switzerland). Angiogenesis in vitro: mechanisms and modulators.

1995 Feb.

Keystone Symposium on Tumor Cell Invasion and Motility. Tamarron (CO, USA). Angiogenesis: a balance between positive and negative regulators.

1995 April

Celltech Therapeutics. Slough (UK). Angiogenesis: a balance between positive and negative regulators.

1995 May

Finsen Laboratory. Denmark (Copenhagen). Angiogenesis: a balance between positive and negative regulators.

1995 May

2nd Franz-Volhard-Symposium on Mechanisms of Angiogenesis. Berlin-Buch (Germany). Angiogenesis: mechanisms and modulators.

1995 July

Gordon Research Conference on Matrix Metalloproteinases. Proctor Academy. Andover (NH, USA). Angiogenesis: mechanisms and modulators.

1995 Sept.

Institute for Molecular Pathology. Vienna (Austria). Angiogenesis: a balance between positive and negative regulators.

1995 Oct.

57th annual meeting of the Société Suisse d'Anatomie, d'Histologie et d'Embryologie. Geneva (Switzerland). Plenary lecture: Clinical applications of angiogenesis research: tilting the balance between positive and negative regulators.

1995 Nov.

Boehringer Ingelheim International Conference on Angiogenesis and Antiangiogenesis. Titisee (Germany). Angiogenesis: a balance between positive and negative regulators.

1996 April

Workshop entitled "Angiogenesis: mechanistic insights and disease" at the 30 th Annual Meeting of the European Society for Clinical Investigation. Interlaken (Switzerland). Angiogenesis: a balance between positive and negative regulators.

1996 Sept.

Symposium entitled "Fallout healing: blood-borne endothelial stem cells", The Hope Heart Institute and Providence Medical Center. Seattle (WA, USA). Endothelial cell ontogeny and mechanisms of vascular formation.

1996 Sept.

IXth International Vascular Biology Meeting.

- 54 -

Seattle (WA, USA). Angiogenesis-regulating cytokines in context. 1996 Sept.

78e réunion annuelle de la Société Suisse de Dermatologie et Vénérologie. Geneva (Switzerland). Régulation positive et negative de l'angiogenèse: de la biologie cellulaire aux applications cliniques.

1997 March

Institut für Genetik, Forschungszentrum Karlsruhe. Karlsruhe (Germany). Angiogenesis: a balance between positive and negative regulators.

1997 May

Novo-Nordisk. Copenhagen (Denmark). Manipulating angiogenesis: from basic science to the bedside.

1997 May

Haartman Institute, University of Helsinki, Helsinki (Finland). Manipulating angiogenesis: from basic science to the bedside.

1997 Aug.

Gordon Research Conference on Angiogenesis and Microcirculation. Salve Regina University. Newport (RI, USA). Balance and context: paradigms which reveal complexity in the regulation of angiogenesis.

1997 Sept.

Philippe Laudat Conference on Biology and Physiopathology of Angiogenesis. Aix-les-Bains (France). Angiogenesis: a balance between positive and negative regulators.

1997 Dec.

Institut d‟Embryologie du CNRS et du Collège de France. Nogent Sur Marne (France). Balance and context: regulatory paradigms for angiogenesis.

1998 Feb.

Sir William Dunn School of Pathology. Oxford (UK). Balance and context: regulatory paradigms for angiogenesis.

1998 Feb.

4th Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). What is angiogenesis: mechanisms of angiogenesis.

1998 March

ImClone Systems, Inc. New York (NY, USA). Manipulating angiogenesis: from basic science to the bedside.

1998 March

Keystone Symposium on Angiogenesis and Vascular Remodelling. Steamboat Springs (CO, USA). Balance and context: regulatory paradigms for angiogenesis.

1998 June

AACR/APMIS conference on proteases and protease inhibitors in cancer. Nyborg (Denmark). Balance and context: regulatory paradigms for angiogenesis.

1999 Feb.

5th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland).

- 55 -

Angiogenesis and mechanisms of vessel wall assembly. 1999 Feb.

Société de Biologie. Paris (France). Angiogenèse et assemblage de la paroi vasculaire.

1999 April

Journées Recherche Sciences de la Vie et de la Santé, Université Joseph Fourier, Grenoble I. Grenoble (France). Plenary lecture: Angiogenèse: de la biologie cellulaire aux applications cliniques.

1999 May

Annual European Vascular Biology Association meeting: endothelial cell activation: inflammation and angiogenesis. Baden (Austria). Werner Risau memorial lecture: Angiogenesis and vessel wall formation: from cell biology to the clinic.

1999 May

Laboratoire de biologie moleculaire et génie génétique, Faculté des Sciences, Université de Liège. Liège (Belgium). Angiogenesis and vessel wall assembly: from cell biology to the clinic.

1999 June

Institute for Medical Radiobiology of the University of Zurich and the Paul Scherrer Institute Villigen (Switzerland) Angiogenesis and vessel wall assembly: mechanistic insights and therapeutic targets.

1999 July

Oncology Workshop, Merck KGaA Darmstadt (Germany) Angiogenesis and vessel wall assembly: mechanistic insights and therapeutic targets.

1999 Aug.

Transgène S.A. Strasbourg (France) Angiogenèse et morphogenèse de l‟arbre vasculaire: de la biologie cellulaire aux applications cliniques.

1999 Sept.

Molecular and Cellular Biology of Plasminogen Activation. Les Diablerets (Switzerland) The PA/plasmin system in PymT-induced vascular tumor formation.

1999 Oct.

Journée rétine. Nyon (Switzerland) Angiogenèse et facteurs de croissance.

2000 Jan.

IBC conference on Therapeutic Control of Angiogenesis. London (UK) Overview of angiogenesis concepts: exploring new opportunities for clinical development.

2000 Jan.

6th Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). Angiogenesis and mechanisms of vessel wall assembly.

2000 April

Department of Clinical Research, University of Bern.

- 56 -

Bern (Switzerland). Manipulating angiogenesis: from cell biology to the clinic. 2000 Sept.

XXVII Congress of the European Society for Artificial Organs. Lausanne (Switzerland). Plenary lecture: Mechanisms of angiogenesis: applications to the vascularization of artificial organs.

2000 Sept.

XIth International Vascular Biology Meeting. Geneva (Switzerland). Plenary lecture: VEGF-C-mediated lymphangiogenesis promotes tumour metastasis.

2000 Oct.

9th Congress of the European Academy of Dermatology and Venerology. Geneva (Switzerland). Plenary lecture: Clinical applictions of angiogenesis research.

2001 Jan.

7th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). Cytokine regulation of vascular tree formation.

2001 Feb.

1st International workshop on new therapeutic targets in vascular biology. Geneva (Switzerland). Lymphangiogenesis and tumor metastasis.

2001 May

Meeting of the “Hinterzartener Kreis für Krebsforschung/Cancer Research” organized by the Deutsche Forschungsgemeinschaft. Cadenabbia (Italy). Lymphangiogenesis and tumor metastasis.

2001 May

Institute of Molecular Oncology, Tumor Biology Center. Freiburg (Germany). VEGF-C-mediated lymphangiogenesis promotes tumour metastasis.

2001 May

3rd Symposium on the Biology of Endothelial Cells. Pathophysiology of the endothelium: vascular and infectious diseases. Giessen (Germany). VEGF-C-mediated lymphangiogenesis promotes tumour metastasis.

2001 June

EntreMed Inc. Rockville (MD, USA). VEGF-C-induced lymphangiogenesis: a novel therapeutic target for tumor metastasis.

2001 June

The Derald H. Ruttenberg Cancer Center, Mount Sinai Medical Center. New York (NY, USA). Lymphangiogenesis and tumor metastasis.

2001 June

ImClone Systems Inc. New York (NY, USA). VEGF-C-mediated lymphangiogenesis mediates tumor metastasis.

2001 June

Swiss Institute for Applied Cancer Research. Oerlikon (Switzerland). Lymphangiogenesis and metastasis.

- 57 -

2001 July

Merck KGaA. Darmstadt (Germany). Lymphangiogenesis and tumor metastasis.

2001 July

XVIIIth Congress of the International Society on Thrombosis and Hemostasis. Paris (France). State of the art lecture: Extracellular proteolysis and angiogenesis.

2001 Sept.

I.S.L. XVIII International Congress of Lymphology. Genova (Italy). Tumor lymphangiogenesis in Rip.VEGF-C transgenic mice.

2001 Nov.

Department of Pathology, University of Bonn. Bonn (Germany). Lymphangiogenesis and tumor metastasis: myth or reality.

2001 Nov.

PALM AG MicroLaser Systems workshop on laser capture microdissection. Bernried (Germany). VEGF-C-mediated lymphangiogenesis promotes tumor metastasis.

2002 Jan.

Sir William Dunn School of Pathology. Oxford (UK). Lymphangiogenesis and tumor metastasis: myth or reality.

2002 Jan.

8th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). First presentation: Angiogenesis and vessel wall assembly. Second presentation: Cell-based delivery of angiogenic growth factors.

2002 Feb.

Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis. Ventura (CA, USA). Proteolysis in angiogenesis and lymphangiogenesis.

2002 Feb.

8th Biennial Meeting of the International Society for Applied Cardiovascular Biology. St. Gallen (Switzerland). Cell-based delivery of angiogenic growth factors.

2002 June

Angiogenesis: basic mechanisms and therapeutic implications. Monte Verita, Ascona (Switzerland). Lymphangiogenesis and tumor metastasis.

2002 July

Angiogenesis Platform, Novartis. Basel (Switzerland). Lymphangiogenesis and tumor metastasis.

2002 Aug.

Serono Pharmaceutical Research Institute. Geneva (Switzerland). Lymphangiogenesis and tumor metastasis.

2002 Sept.

Angiogenesis: molecular mechanisms and functional interactions. Kloster Seeon (Germany). VEGF-C-mediated lymphangiogenesis promotes tumor metastasis.

2002 Oct.

6ème Journée d'Interaction des Groupes de Recherche des Facultés de Médecine

- 58 -

de Genève et Lausanne. Changins (Switzerland). Lymphangiogenesis and tumor metastasis. 2002 Nov.

Novartis Foundation (prev. Ciba Foundation) symposium no. 256 on Inflammation and Cancer. London (UK). Lymphangiogenesis and tumor metastasis.

2002 Nov.

Swiss Society for Oncology meeting on “Breast cancer: biology and therapy”. Lausanne (Switzerland). Lymphangiogenesis and tumor metastasis.

2002 Nov.

Austrian Vascular Biology Organization. Vienna (Austria). Plenary lecture: The lymphatic vascular system: a renaissance.

2003 Jan.

“Onkologische Grundlagenforschung” seminar series, University of Basel. Basel (Switzerland). Lymphangiogenesis and tumor metastasis.

2003 Feb.

New Therapeutic Targets in Vascular Biology. Geneva (Switzerland). Lymphangiogenesis and tumor metastasis.

2003 Feb.

Signaling in breast cancer and new therapeutic approaches. Nice (France). Lymphangiogenesis and tumor metastasis.

2003 March

35th Annual Meeting of the Swiss Societies for Experimental Biology. Davos (Switzerland). Lymphangiogenesis and tumor metastasis.

2003 May

Boehringer Ingelheim meeting on Lymphangiogenesis. Baden/Vienna (Austria). Lymphangiogenesis and tumor metastasis.

2003 June

2nd Institut Pasteur Euroconference on Angiogenesis. Paris (France). Lymphangiogenesis and tumor metastasis.

2003 June

International Meeting on Angiogenesis in Cancer. Reykjavik (Iceland). VEGF-C-mediated lymphangiogenesis promotes tumor metastasis.

2003 Aug.

Department of Medicine, Johannesburg General Hospital. Johannesburg (South Africa). Manipulating angiogenesis: from basic science to the bedside.

2003 Nov.

69. Jahresversammlung Schweizerische Gesellschaft für Pathologie. Ittingen (Switzerland). Lymphangiogenesis and tumor metastasis.

2003 Nov.

Journées medico-chirurgicales d‟hépatologie et de gastroenterologie. Geneva (Switzerland). Métastases lymphogènes des tumours digestives.

- 59 -

2003 Dec.

Wallenberg Laboratory, Sahlgrenska University Hospital. Gothenburg (Sweden). The lymphatic vascular system: a renaissance.

2003 Dec.

Institute of Pathology, University of Bern. Bern (Switzerland). Lymphangiogenesis and tumor metatsasis.

2004 March

Gordon Research Conference on Molecular Mechanisms in Lymphatic Function and Disease. Ventura (CA, USA). Lymphangiogenesis and tumor metatsasis.

2004 Aug.

Biomedicum Helsinki. Helsinki (Finland). Hemangiomas and vascular malformation: new insights into their pathogenesis and treatment.

2004 Aug.

Regenerative Medicine. Turku (Finland). The lymphatic vascular system: a renaissance.

2004 Oct.

Roche In Vitro Diagnostics Forum. Johannesburg (South Africa). Genes guide the way - a promise of new technology.

2004 Oct.

Belgian Society for Cell and Developmental Biology. Liège (Belgium). Lymphangiogenesis and tumor metastasis.

2005 Feb.

Roche Molecular Diagnostics. Cape Town (South Africa). Pharmacogenetics.

2005 Feb.

Department of Molecular Medicine and Hematology, University of the Witwatersrand. Johannesburg (South Africa). Vascular malformations and hemangiomas: from cell biology to the clinic.

2005 June

Roche 1st Central and Eastern European In Vitro Diagnostics Forum. Athens (Greece). Genes lead the way: a promise of new technology.

2005 June

Department of Molecular Medicine and Hematology, University of the Witwatersrand. Johannesburg (South Africa). The power of pharmacogenetics.

2005 Aug.

Nelson R. Mandela School of Medicine, University of KwaZulu-Natal. Durban (South Africa). The power of pharmacogenetics.

2005 Nov.

Merck KGaA. Darmstadt (Germany). Insights into the mechanisms of angiogenesis: identification of novel therapeutic targets.

2006 May

University of Ulm, Department of Medicine. Ulm (Germany). Cell-based therapy in the heart – the South African potential.

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2006 Aug.

44th Annual Congress of the South African Gastroenterology Society. Port Elizabeth (South Africa). The genetics of obesity.

2006 Sept.

XXIXth International Congress of the International Society of Blood Transfusion. Cape Town (South Africa). State-of-the-art lecture: Stem cell plasticity.

2006 Sept.

Society for the Advancement of Blood Management Annual Meeting. Jersey City (NJ, USA). Plenary lecture: South African Blood Conservation Program.

2007 Feb.

Biological Psychiatry Congress 2007. From Molecules to Mind: Bridging the Gap. Somerset West (South Africa). Amplichip CY450 genotype profiling: improving treatment outcomes in psychiatric disorders.

2007 May

South African Medicolegal Society. Pretoria (South Africa). Stem cells: current reality and future promise.

2007 June

Bioethics Forum on Public and Private Stem Cell Banking. Pretoria (South Africa). Public and private stem cell banking: scientific arguments.

2007 Aug.

AfricaBio: Biotechnology and Stem Cell Research. Centurion (South Africa). Cell-based therapy in South Africa.

2007 Sept.

South African division of the International Association for Dental Research. Centurion (South Africa). Stem cells: what are they and how will they affect dentistry in the future?

2007 Sept.

Bio2Biz SA 2007. Cape Town (South Africa). Stem cells. Current reality and future promise.

2008 Jan.

SASOM Bariatric Workshop. Pretoria (South Africa). Genetics and epigenetics of obesity: key points.

2008 July

National Biotechnology Advisory Committee Workshop. Pretoria (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.

2008 Sept.

Bio2Biz 2008. Johannesburg (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.

2008 Oct.

International Physiotherapy Congress. Pretoria (South Africa). Stem cells: current reality and future promise.

2008 Oct.

Biotechnology in Medical Research – Media Round Table (SAASTA/PUB). Cape Town (South Africa). Health Biotech in South Africa.

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2009 Feb.

College of Agriculture and Environmental Sciences, University of South Africa. Johannesburg (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.

2009 May

California NanoSystems Institute (CNSI), University of California, Los Angeles. Los Angeles (CA, USA). Bedside to bench: defining the market in health biotechnology in South Africa.

2009 May

In Vivo and Cellular Molecular Imaging Center Seminar Series, Johns Hopkins University School of Medicine. Baltimore (MD, USA). Bedside to bench: defining the market in health biotechnology in South Africa.

2009 May

The Human Tissue Regulatory Environment. Pretoria (South Africa). The Stem Cell Regulatory Environment in South Africa.

2009 July

SA Bio Plan – Emory Goizueta Business School. Stellenbosch (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.

2009 Aug.

Innov8 Pub @ Hub. Pretoria (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.

2009 Sept.

Department of Jurisprudence, School of Law, University of South Africa. Pretoria (South Africa). The Stem Cell Regulatory Environment in South Africa: operating in a regulatory vaccuum.

2009 Sept.

Bio2Biz. Durban (South Africa). Impediments to the establishment of stem cell technology in South Africa.

2009 Sept.

Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). 1. Bedside to bench - defining the market in health biotechnology in South Africa. 2. Cell-based thearpy.

2009 Nov.

31st South African National Blood Transfusion Congress. Johannesburg (South Africa). Sustainability strategies in public cord blood banking.

2009 Nov.

Technology transfer in South Africa (SARIMA/WBI). Cape Town (South Africa). A meta-analysis of studies on tech transfer in South Africa.

2009 Nov.

Stem Cells – Media Round Table (SAASTA/PUB). Durban (South Africa). Cell-based therapy.

2010 Feb.

Steve Biko Centre for Bioethics, University of the Witwatersrand. Reproductive Health – Ethics and Law. Johannesburg (South Africa). Cord blood collection and banking.

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2010 March

South African Transplantation Society. 3rd Controversies in Transplantation Meeting. Mount Grace (South Africa). Human tissue legislation: revision of Chapter 8 of the NHA and associated regulations.

2010 March

South African Genetics Society 21st Congress. Bloemfontein (South Africa). Genomic Sovereignty.

2010 May

Bestmed Annual General Meeting. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.

2010 May

Department of Molecular Medicine and Hematology, Wits University. Johannesburg (South Africa). Mapping the human genome: the dawning of a new era in healthcare.

2010 Aug.

Transplantation Indaba Cape Town (South Africa). Overview of stem cell principles and legislation.

2010 Aug.

Faculty Day, Faculty of Health Sciences, University of Pretoria. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.

2010 Sept.

NBAC national workshop on Feeding the Biotechnology Pipeline. Pretoria (South Africa). The regulatory environment and the new Bio-economy in South Africa.

2010 Oct.

Human tissue use: medico-legal and ethical implications. Durban (South Africa). The Amendments to Chapter 8 of the National Health Act and Regulations thereto.

2010 Oct.

Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.

2010 Nov.

Medi-Clinic Southern Africa Management Committee. Stellenosch (South Africa). Cell-based therapy.

2010 Nov.

Biotechnology landscape in South Africa – Media Round Table (SAASTA/PUB). Cape Town (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.

2011 Jan.

Muelmed Hospital Physiotherapy/Rehab Department. Pretoria (South Africa). Cell-based therapy.

2011 March

University of Pretoria and the South African Paediatric Association. Update 2011. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.

2011 March

Post-graduate Diploma in Transfusion Medicine. University of the Free State. Bloemfontein (South Africa). Cord blood stem cell banking.

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2011 April

The Nestle Nutrition Institute Africa and the Departnment of Human Nutrition (University of Pretoria) – 8th CNE. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.

2011 May

Pan-African Ethics, Human Rights and Medical Law. Johannesburg (South Africa). The southern African Human Genome Programme: some ethical, legal and social issues.

2011 May

2nd Neuroscience Day, University of Pretoria. Pretoria (South Africa). Epigenetics in the Neurosciences.

2011 July

Department of Immunology, University of Cape Town. Cape Town (South Africa). Cord blood stem cell banking: a realistic option for South Africa.

2011 Aug.

Department of Science and Technology. Pretoria (South Africa). Genomic sovereignty.

2011 Aug.

Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.

2011 Sept.

Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Cape Town (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.

2011 Oct.

University of Limpopo. Polokwane (South Africa). Cell-based therapy.

2011 Oct.

South African Society of Physiotherapy. Pretoria (South Africa). Cell-based therapy.

2011 Nov.

Ethics Workshop, Faculty of Health Sceinces, University of Pretoria. Pretoria (South Africa). Ethical, legal and social issues of the Southern African Human Genome Programme.

2011 Nov.

SAASTA/PUB Critical Thinker‟s Forum on the Southern African Human Genome Programme. Cape Town (South Africa). Human Genome introductory lecture.

2012 Feb.

Division of Human Genetics, NHLS and University of the Witwatersrand. Johannesburg (South Africa). Cell-based therapy.

2012 March

NBAC National Workshop: Bioprospecting South Africa‟s biodiversity: a driver for the new bioeconomy. Pretoria (South Africa). The human genome.

2012 June

Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Grahamstown (South Africa). Lecture 1: Bedside to bench - defining the market in health biotechnology in South Africa.

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Lecture 2: Cell-based therapy. 2012 July

Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Durban (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.

2012 August

Legal aspects relating to the applications of biotechnology, College of Law, Unisa. Pretoria (South Africa). Human tissue legislation in South Africa – a need for self-regulation?

2012 Aug. & Sept.

Medical malpractice litigation seminar, Institute for Cellular and Molecular Medicine. Pretoria (South Africa). Medical malpractice litigation in South Africa.

2012 Sept.

Sci-Enza Sci-Enza, in collaboration with Public Understanding of Biotechnology (PUB). Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.

2012 Sept.

Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.

2012 Oct.

Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Cape Town (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.

2012 Oct.

9th Expert Lecture, University of Pretoria. Pretoria (South Africa). Stem cells: current reality and future promise.

2012 Nov.

swissnexDay‟12: Brain Circulation. Bern (Switzerland). Emigration des cerveaux.

2012 Nov.

SAASTA/PUB Critical Thinker‟s Forum on Stem Cells. Doornkloof (South Africa). Stem Cells introductory lecture.

2013 March

16th International Society of Radiolabelled Blood Elements Congress. Pretoria (South Africa). Stem Cell Research and Therapy: an Overview.

2013 May

Vitalab Journal Club. Johannesburg (South Africa). Stem Cell Research and Therapy: an Overview.

2013 May

4th Annual PD Rose Plenary Lecture, Rhodes University. Grahamstown (South Africa). Stem Cells: the Hype and the Hope.

2013 May

Institute for Food, Nutrition and Wellbeing, University of Pretoria. Pretoria (South Africa). We are what we eat – at the interface between molecular medicine and nutrition.

2013 June

Otorinolaryngology journal club. Pretoria (South Africa). Medical malpractice litigation.

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2013 June

Obstetrics and Gynaecology meeting on medical malpractice and legal matters. Johannesburg (South Africa). Medical malpractice litigation.

2013 July

Pretoria Boys High School. Pretoria (South Africa). Stem cells: the hype and the hope.

2013 August

International Centre for Genetic Engineering & Biotechnology (ICGEB). Cape Town (South Africa). Stem cells: the hype and the hope.

2013 August

Faculty Day, Faculty of Health Sciences, University of Pretoria Pretoria (South Africa). The lymphatic tree: the often forgotten second vascular system.

2013 August

Ethical and Legal Issues on Biobanking, College of Law, Unisa Pretoria (South Africa). Private versus public biobanks.

2013 Sept.

International Association for Dental Research (SA Division) Annual Congress Kammeeldrift (South Africa). Stem cells: the hype and the hope.

2013 Sept.

41st Conference of the Physiology Society of Southern Africa Roode Vallei (South Africa). Stem cells: the hype and the hope.

2013 Sept.

Postgraduate Diploma in Transfusion Medicine, University of the Free State Bloemfontein (South Africa). Lecture 1: Stem cells: the hype and the hope. Lecture 2: Human tissue legislation.

2013 Oct.

The future and sustainability of biobanks in South Africa to support indigenous research. Sandringham (South Africa). SA National Health Act and biobanking.

2013 Oct.

15th Biennial Congress of the Southern African Society for Human Genetics. Sandton (South Africa). Lecture 1: Objectives and future medical relevance of the SAHGP. Lecture 2: Mesenchymal stem cells: adult stem cells with potentially wide therapeutic applications.

2013 Oct.

Emerging Health Technologies Seminars, CSIR. Pretoria (South Africa). Stem cells: the hype and the hope.

2013 Oct.

Launch of the DST/NRF SARChI Chair in Mathematical Models and Methods in Bioengineering and Biosciences. Pretoria (South Africa). Angiogenesis and lymphangiogenesis: importance in tumor growth and metastasis.

2013 Nov.

Dept. of Molercular Medicine and Haematology, University of the Witwatersrand. Johannesburg (South Africa). Stem cells: the hype and the hope.

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2013 Nov.

Ethics Workshop, Faculty of Health Sceinces, University of Pretoria. Pretoria (South Africa). Medical malpractice litigation in South Africa.

2013 Nov.

Seminar Day, Genomics Research Institute, University of Pretoria. Pretoria (South Africa). The Human Genome – a novel perspective.

2013 Nov.

University of the West Indes, Mona Campus. Kingston (Jamaica). Angiogenesis and lymphangiogenesis – importance in tumor growth and metastasis.

2013 Nov.

University of Technology. Kingston (Jamaica). Angiogenesis and lymphangiogenesis – importance in tumor growth and metastasis.

2013 Nov.

2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus. Kingston (Jamaica). The Human Genome.

2013 Nov.

2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus. Kingston (Jamaica). Stem cells – current reality and furure promise.

2014 Feb.

2014 National Life Science Conference of the IEB. Johannesburg (South Africa). Stem cells – current reality and furure promise.

2014 August

SASOG Gauteng North. Pretoria (South Africa). Sex determination and gender identity.

2014 August

International Conference on Tissue Engineering and Regenerative Medicine. Pretoria (South Africa). Establishment of a sustainable public cord blood stem cell bank for South Africa.

2014 Sept.

Consensus study on homosexuality. Bellagio (Italy). Sex determination and gender identity.

2014 Nov.

Bridging Science, Business, and Politics: the Role of Responsible Leadership in Creating the Necessary Transition to a Sustainable Global Economy. Pretoria (South Africa). Sustainable outcomes in stem cell and genomics research - the role of responsible leadership.

2014 Nov.

Opportunities and responsibilities in genomic and stem cell research in South Africa. Potchefstroom (South Africa). Building capacity to investigate the role of mitochondrial DNA variants in Black African populations.

2014 Nov.

3rd Worldwide Network for Blood and Marrow Transplantation workshop (in partnership with the WHO) Cape Town (South Africa). Human Tissue Legislation.

2014 Dec.

CSIR course on Induced Pluripotent Stem Cell Technology. Pretoria (South Africa). 1. Stem cells in SA: history and current status 2. Stem cell legislation/ethics/clinical application

2014 Dec.

Du Tissu Graisseux a la Cellule Souche: Medecine et Chirurgie Regenerative Geneva (Switzerland).

- 67 Les possibilites therapeutiques des cellules souches en 2014.

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ABSTRACTS Published abstracts 1.

Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Endothelial cell-matrix interactions in angiogenesis. Coll. Rel. Res. 8(6): 516, 1988.

2.

Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Proteolytic balance and capillary morphogenesis in vitro. J. Mol. Cell. Cardiol. 23 (Suppl. 5): S16, 1991.

3.

Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Regulation of capillary morphogenesis in vitro. J. Cell. Biochem. Suppl. 16F: 75, 1992.

4.

Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Proteolytic balance and in vitro morphogenesis. Fibrinolysis 6 (Suppl. 2): 31, 1992.

5.

Pepper M.S., Wagner E., Fotsis T., Schweigerer L., Ferrara N., Risau W., Orci L., Vassalli J.-D. and Montesano R.: Angiogenesis: a balance between positive and negative regulators. J. Cell. Biochem. Suppl. 19B: 5, 1995.

6.

Soriano J.V., Pepper M.S., Nakamura T., Orci L. and Montesano R.: Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. Experientia 51: A62, 1995.

7.

Mandriota S.J., Seghezzi G., Vassalli J.-D., Montesano R., Mignatti P. and Pepper M.S.: Vascular endothelial growth factor modulates extracellular proteolytic activity in vascular endothelial cells. Experientia 51: A65, 1995.

8.

Pepper M.S., Vassalli J.-D., Orci L. and Montesano R. Regulation of angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis. Kidney Int. 47(2): 659, 1995.

9.

Zimrin A.B., Pepper M.S., Montesano R. and Maciag T. An antisense oligonucleotide to the notch ligand jagged promotes angiogenesis in bovine microvascular endothelial cells (BMEC) on collagen gels. FASEB J 10(6): A1094, 1996

10. Lucas, R., Sablon E., Echtenacher B., Ameloot P., Magez S., Juillard P., Pepper M.S., Vandenabeele P., Hofmeister R., Bosman F., Fransen L., Montesano R., Grau G.E. and De Baetseiler P. A mouse TNF mutein with reduced toxicity, but with equal tolerizing, anti-angiogenic and protective activities. Eur. Cytokine Netw. 7(2): 236, 1996. 11. Lucas, R., Lou J.N., Donati Y.R.A., Mandriota S.J., Decrind C., Pepper M.S., Monso-Hinard C., Moore M.W., Bluethmann H. and Grau G.E. Both TNF receptors are needed to mediate TNF-induced cytotoxicity in microvascular endothelial cells. Eur. Cytokine Netw. 7(2): 235, 1996. 12. Pepper M.S., Mandriota S.J., Vassalli J,-D., Orci L. and Montesano R. Angiogenesis: a balance between positive and negative regulators. Eur. J. Clin. Invest. 26 (Suppl. 1): A38, 1996. 13. Mandriota S.J., Menoud P.-A. and Pepper M.S. Regulation of vascular endothelial growth factor receptor 2/FLK-1 expression in vascular endothelial cells. Eur. J. Clin. Invest. 26 (Suppl. 1): A38, 1996. 14. Gorden D.L., Mandriota S.J., Montesano R. and Pepper M.S. Modulation of vascular endothelial growth factor expression in isolated islets of Langerhans. Eur. J. Clin. Invest. 26 (Suppl. 1): A39, 1996. 15. Zimrin A.B., Pepper M.S., Montesano R. and Maciag T. An antisense oligonucleotide to the Notch ligand Jagged promotes angiogenesis in bovine microvascular endothelial cells (BMEC) on collagen gels. FASEB J. 10(6): 547, 1996.

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16. Masouyé I., Pepper M.S., Saurat J.H., Veerkamp J.H., Siegenthaler G. Endothelial cells from human skin express epidermal fatty acid-binding protein (E-FABP). J. Invest. Dermatol. 107(2): C18, 1996. 17. Hagens G., Masoye I., Pepper M.S., Madsen P., Saurat J.H., Veerkamp J.H and Siegenthaler G. Endothelial cells from human blood capillaries also express the epidermal fatty acid-binding protein. J. Invest. Dermatol. 107(3): 25, 1996 18. Thommen R., Humar R., Misevic G., Pepper M.S. and Battegay E.J. PDGF-BB increases endothelial migration and cord movements during angiogenesis in vitro. Microcirculation 4: 143, 1997. 19. Lucas R., Holmgren L., Mandriota S.J., Jimenez B., Garcia I., Montesano R., Grau G.E., Shing Y. and Pepper M.S. Cytotoxicity of TNF versus angiostatin in microvascular endothelial cells in vitro. Eur. J. Surg. Oncol. 24: 224, 1998. 20. Miralbell R., Tolnay M., Bieri S., Sappino A.P., Probst A., Pizzolato G. and and Pepper M.S. Pediatric medulloblastoma: prognostic significance of MIB-1, p53, bcl-2, and von Willebrand immunoreactivity. Med. Ped. Oncol. 31: 229, 1998. 21. Olofsson B., Korpelainen E., Pepper M.S., Mandriota S.J., Kumar V., Aase K.A.Y., Gunji Y., Alitalo K. and Eriksson U. VEGF-B binds to VEGFR-1 and regulates plasminogen activator activity in endothelial cells. Mol. Biol. Cell 9 (Suppl 5): 114A, 1998. 22. March K.L., Nguyen A.T., Gurudutt V.V., Fineberg N., Mahomed Y., Sharp T., Aufiero T., Brown J. and Pepper M. Human pericardial fluid often displays potent angiogenic inhibitory activity in patients with cardiac ischemia. Circulation 100(18): 407, 1999. 23. Pepper M.S., Rosnoblet C. and Kruithof E.K.O. Synergistic induction of tPA by VEGF and bFGF and localization of tPA to Weibel-Palade bodies in bovine microvascular endothelial (BME) cells. Fibrinolysis Proteolysis 14 (Suppl. 1): 20, 2000. 24. Tille J.-C., Wood J., Mandriota S.J., Schnell C., Ferrari S., Mestan J. and Pepper M.S. VEGFR-2 tyrosine kinase inhibitors inhibit bFGF- and VEGF-induced angiogenesis in vivo and in vitro. J. Submicrosc. Cytol. Pathol. 32 (30): 456, 2000. 25. Nisato R., Tille J.angiogenesis. J. Submicrosc. Cytol. Pathol. 32(3): 435, 2000. 26. Alizadeh N., Pepper M.S. and Pittet B. A model of ulcer healing in the ischemic limb. J. Submicrosc. Cytol. Pathol. 32(3): 430, 2000. 27. Alizadeh N., Pittet B., Pyke C., Baetens D., Montandon D., Ezban M. and Pepper M.S. Active-site inactivated FVIIa (FVIIai) increases viability in a skin flap model of acute ischemia. J. Submicrosc. Cytol. Pathol. 32(3): 409, 2000. 28. Mandriota S.J., Jussila L., Jeltsch M., Compagni A., Prevo R., Banerji S., Huarte J., Baetens D., Montesano R., Jackson D., Orci L., Alitalo K., Christofori G. and Pepper M.S. VEGF-C-mediated lymphangiogenesis promotes tumour metastasis. J. Submicrosc. Cytol. Pathol. 32(3): 384, 2000. 29. Schlaudraff K.U., Pepper M., Ehrenburg I.V., Tkatchouk E.N., Montandon D. and Pittet B. Influence of intermittent hypoxia training on the survival of ischemic dorsal random skin flaps in the rat. Hypoxia Med. J. 9: 29, 2001. 30. Pepper M.S. Cell-based delivery of angiogenic growth factors. Cardiovasc. Pathol. 11: 8, 2002.

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31. Podograbinska S., Velasco P., Detmar M., Pepper M., Jackson D. and Skobe M. Molecular profile of the lymphatic endothelium. Lymphatic Res. Biol. 1: 92, 2003. 32. Bochaton-Piallat M.L., Hao H., Verin V., Camenzind E., Pepper M.S. and Gabbiani G. Porcine coronary artery smooth muscle cells are phenotypically heterogeneous. Arterioscl. Thromb. Vasc. Biol. 23(5): A47, 2003 33. Mathe Z., Dupraz P., Bosco D., Bucher P., Zbinden M., Rinsch C., Thorens B., Berney T, Pepper M.S. Retroviral transduction of pancreatic beta-cells by VEGF-164 improves glycemic control in a syngeneic model of islet cell transplantation. Transplantation 76(4): S60-S61, 2003. 34. Wernert N., Okuducu A. and Pepper M.S. Ets 1 is expressed in capillary blood vessels but not in lymphatics. Pathol. Res. Practice. 200(4): 260, 2004 35. Mathe Z., Dupraz P., Zbinden M., Bosco D., Filo A., Bucher P., Rinsch C., Thorens B., Berney T, Pepper M.S. Regulated gene expression of VEGF-164 by pancreatic beta-cells improves revascularization and engraftment after transplantation. Diabetologia 47: A181, 2004. 36. Nisato R.E., Harrison J.A., Buser R., Orci L., Rinsch C., Montesano R., Dupraz P. and Pepper M.S. Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended lifespan. Anticancer Res. 24(5D): 3582, 2004. 37. Hao H., Geinoz A., Ropraz P., Verin V., Camenzind E., Pepper M.S, Sanchez J.C., Gabbiani G. and Bochaton-Piallat M.L. Heterogeneity of smooth muscle cell populations cultured from pig coronary artery. Cardiovasc. Pathol. 13(3, Supplement): S159-160, 2004. 38. Friedrichs N., Hahne J., Pepper M.S., Rommerscheidt-Fuss U., Buettner R., Stelzner F and Wernert N. Immunohistochemical quantification of lympf vessels, VEGF-C and VEGFR-3 in human sarcomas. Pathol. Res. Practice. 201(3): 204, 2005. 39. Rubbia-Brandt L., Terris B., Giostra E., Dousset B., Morel P. and Pepper M.S. Lymphatic vessel density and VEGF-C expression correlate with malignant behaviour in human pancreatic endocrine tumors. Modern Pathol. 18 (Suppl 1): 285A, 2005. 40. Rubbia-Brandt L., Terris B., Giostra E., Dousset B., Morel P. and Pepper M.S. Lymphatic vessel density and VEGF-C expression correlate with malignant behaviour in human pancreatic endocrine tumors. Lab. Invest. 85 (Suppl 1): 285A, 2005. 41. Ballmer-Hofer K., Suarez S.C., Hoffmann U., Pepper M. and Nisato R. Altered signalling of an inhibitory VEGF-A splice variant results from a defect in heparin binding: implications for angiogenesis in development and tissue repair. FEBS J. 272 (Suppl 1): 218, 2005. 42. Pepper M. AmpliChip CYP450 genotype profiling for improving treatment outcomes in psychiatric patients. S. Afr. J. Psychiatry 13(1): 33-34, 2007. 43. Ammar A., Muhammed R., Patel P., Salmi M., Pepper M., Nissato R., Paish E.C., Ellis I. and Martin S.G. The role of CLEVER-1 in breast tumour metastasis. Eur. J. Cancer Supplements 5(3): 27, 2007. 44. van der Merwe M.T., Logan M., Pieters J.H., Sammi Y. and Pepper M.S. Sustained weight loss after an 18-month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. J. Endocrinol. Metab. Diabetes S. Afr. 12(1): 46, 2007. 45. Van der Merwe T., Logan M., Pieters J., Sammi Y. and Pepper M. Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. Int. J. Obesity 31(S1):S116, 2007.

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46. Ammar A., Mohammed R., Salmi M., Pepper M., Paish E., Ellis I., Patel P. and Martin S.G. Role of CLEVER-1 in breast cancer metastasis. Breast Cancer Res. 10 (Suppl 2): S19-S20, 2008. 47. Logan M.G., Pepper M.S., van der Merwe M.T. and Fetter G.K. Early changes following bariatric surgery in South Africa. 43rd SEMDSA Congress. Cape Town, South Africa. 12-15 April, 2008. J. Endocrinol. Metab. Diabetes South Afr. 13(1): 35, 2008. 48. Logan M., Pepper M.S. and van der Merwe M.T. Early changes following bariatric surgery in South Africa. Int. J. Obesity 32 (Suppl 1): S51, 2008. 49. Mabeta P. and Pepper M.S. Evaluation of the antiangiogenic effects of bleomycin in vitro. J. Physiol. Sci. 59 (Suppl 1): 322, 2009. 50. Dodgen T., Cromarty D., Fickl H. and Pepper M. CYP2D6 and CYP2C19: a comparison of direct versus predicted phenotyping in a South African population. Basic Clin. Pharmacol. Toxicol. 107(Supplement s1): 259, 2010. 51. Modarressi A., Pietramaggiori G., Alizadeh N., Pepper M.S., Bochaton-Piallat M.L., Hinz B. and Pittet, B. Myofibroblasts play a key role in delayed wound healing in ischemia. Br. J. Surg. 97 (Suppl 4): S29, 2010. 52. Alessandrini M., Beltchev E., Pool R. and Pepper MS. Evaluation of the AMLprofiler in the South African context: report on preliminary findings. Blood 122 (21): online only, 2013. 53. Mabeta P, Davis P.F. and Pepper M.S. mTOR/PI3k/Akt signaling pathway in tumor angiogenesis and therapeutic targeting. Anticancer Res. 34: 6042, 2014. Other abstracts 54. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Endothelial cell-extracellular matrix interactions in angiogenesis. Proceedings of the Symposium on Growth, Differentiation and Pathology of the Vascular Endothelium, Schloß Ringberg (Germany). 5-8 October 1988. 55. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Endothelial cell-matrix interactions and cell invasiveness in angiogenesis. Proceedings of the 19th meeting of the Federation of European Biochemical Societies, Rome (Italy). 2-7 July 1989. 56. Pepper M.S., Spray D.C., Chanson M., Montesano R. and Orci L.: Junctional communication is induced in migrating capillary endothelial cells. Proceedings of the meeting on Molecular and Cell Biology of Gap Junctions, Irsee (Germany). 18-23 July 1989. 57. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Angiogenesis in vitro: morphogenetic and invasive properties of endothelial cells. Proceedings of the meeting of the British Society for Cell Biology, Manchester (U.K.). 3-6 April 1990. 58. Vassalli J.-D., Wohlwend A., Belin D., Pepper M., Montesano R. and Orci L.: Cytokines in the control of extracellular proteolysis. Proceedings of the First International Congress on Inflammation, Barcelona (Spain). 17-22 June 1990. 59. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Proteolytic balance and capillary morphogenesis in vitro. International Symposium on Angiogenesis, St. Gallen, (Switzerland). 13-15 March 1990. 60. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Modulation of angiogenesis in vitro. International Symposium on Angiogenesis, St. Gallen, (Switzerland). 13-15 March 1990.

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61. Pepper M.S., Vassalli J.-D., Orci L. and Montesano R.: Angiogenesis in vitro: modulation of extracellular proteolysis and cell-extracellular matrix interactions. Proceedings of the 2nd Symposium on Growth, Differentiation and Pathology of Vascular Endothelium, Ringberg Castle (Germany). 16-19 October 1991. 62. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis. Proceedings of the VIIth International Symposium on the Biology of Vascular Cells, San Diego (California, USA). 10-14 November 1992. 63. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis. Proceedings of the NATO Advanced Study Institute on Angiogenesis: Molecular Biology, Clinical Aspects, Rhodes (Greece). 16-27 June 1993. 64. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Role of growth factors and extracellular matrix in angiogenesis and epithelial morphogenesis. Proceedings of the International Symposium on Developmental Endocrinology, Geneva (Switzerland). 30 September - 2 October 1993. 65. Fotsis T., Pepper M., Adlercreutz H., Hase T., Montesano R. and Schweigerer L. Genistein and angiogenesis inhibition. Proceedings of the 1st International Symposium on the role of Soy in Preventing and Treating Chronic Disease, Mesa (Arizona, USA). 20-23 February 1994. 66. Adlercreutz H., Fotsis T., Schweigerer L., Pepper M., Attalla H., Zhang Y., Wähälä C., Montesano R., Nawroth P.P. and Hase T.: Isoflavonoids and 2-methoxyestradiol: inhibitors of tumor cell growth and angiogenesis. Proceedings of the 85th AACR Annual Meeting "Novel Strategies in Chemical Chemoprevention of Cancer", San Francisco (California, USA). 10-13 April 1994. 67. Pepper M.S., Vassalli J.-D., Orci L. and Montesano R. Angiogenesis in vitro: cytokine interactions and balanced proteolysis. Proceedings of the VIIIth International Symposium on the Biology of Vascular Cells, Heidelberg (Germany). 30 August - 4 September 1994. 68. Fotsis T., Pepper M. Aktas E., Joussen A., Kruse F., Adlercreutz H., Hase T., Montesano R. and Schweigerer L.: Inhibitors of angiogenesis in human urine. Proceedings of the NATO Advanced Study Institute on Molecular Cellular and Clinical Aspects of Angiogenesis Porto Carras, Halkidiki (Greece). 1627 June, 1995. 69. Montesano R., Vassalli J.-D., Orci L. and Pepper M.S.: Endothelial and tubular morphogenesis. XIIIth International Congress of Nephrology, Madrid (Spain). 2-6 July, 1995. 70. Fotsis T., Pepper M., Aktas E., Joussen A., Kruse F., Adlercreutz H., Hase T., Montesano R. and Schweigerer L.: Dietary inhibitors of angiogenesis. Proceedings of the 11th IFCC European Congress of Clinical Chemistry, Tampere (Finland). 2-7 July, 1995. 71. Pepper M.S., Wagner E.F., Mandriota S.J., Vassalli J,-D., Orci L. and Montesano R. Angiogenesis: a balance between positive and negative regulators. Proceedings of the Boehringer Ingelheim International Conference on Angiogenesis and Anti-angiogenesis, Titisee (Germany). 1-5 November, 1995. 72. Pepper M.S., Montesano R. Mandriota S.J., Orci L. and Vassalli J.-D. Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis. Proceedings of the American Association for Cancer Research conference on Proteases and Protease Inhibitors in Cancer, Panama City (FL, USA). 1-5 March, 1996. 73. Hagens G., Masouyé I., Pepper M.S., Madsen P., Saurat J.H., Veerkamp J.H., Siegenthaler G. Endothelial cells from human blood capillaries also express the epidermal fatty acid-binding protein. Proceedings of the 25th meeting of the European Society for Dermatological Research, Amsterdam, The Netherlands. 28 September - 1 October, 1996.

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74. Montesano R., Soriano J.V., Pepper M.S., Orci L. Induction of epithelial branching tubulogenesis in vitro. Proceedings of the 9th Conference of the International Society of Development, Cell Differentiation and Cancer, Pisa, Italy. 28 September - 2 October, 1996. 75. Lucas R., Lou J.N., Mandriota S., Pepper M., Suter P.M., Bluethmann H. and Grau G. TNF cytotoxicity in pulmonary microvascular endothelial cells in the presence versus absence of transcriptional inhibitor. Proceedings of the 29th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Geneva, Switzerland. 20-21 March 1996. 76. Pepper M.S. and Montesano R. Manipulating angiogenesis: from basic science to the bedside. Proceedings of the 29th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Geneva, Switzerland. 20-21 March 1996. 77. Mandriota S.J. and Pepper M.S. Regulation of vascular endothelial growth factor (VEGF) and VEGF receptor expression in vascular endothelial cells. Proceedings of the 29th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Geneva, Switzerland. 20-21 March 1996. 78. Tenan M., Diserens A.C., El Atifi M., Brunet J.F., Albertoni M., Fulci M., de Tribolet N., Feige J.J., Pepper M. and Van Meir E.G. Overexpression of thrombospondin-1 is anti-tumorigenic in glioblastoma. Proceedings of the 12th International Conference on Brain Tumour Research and Therapy, Keble College, Oxford, U.K. 20-23 September, 1997. 79. Pepper M.S. Angiogenesis. Proceedings of the 4th local drug delivery meeting and cardiovascular course on radiation and molecular strategies, Geneva, Switzerland. 26-28 February, 1998. 80. Bochaton-Piallat M.-L., Gabbiani G. and Pepper M.S. Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Proceedings of the 4th local drug delivery meeting and cardiovascular course on radiation and molecular strategies, Geneva, Switzerland. 26-28 February, 1998. 81. Lucas R., Holmgren L., Mandriota S.J., Jimenez B., Garcia I., Grau G.E., Shing Y. and Pepper M.S. Angiostatin induces apoptosis in endothelial cells. Proceedings of the 30th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Lausanne, Switzerland. 5-6 March 1998. 82. Pepper M.S. Balance and context: regulatory paradigms for angiogenesis. Proceedings of the Keystone Symposium on Angiogenesis and Vascular Remodeling, Steamboat Springs, CO, USA. 28 March - 3April, 1998. 83. Cavallaro U., Wu Z., Pepper M.S., Montesano R. and Soria M.R. Crosstalk between angiogenic growth factors in the migration of vascular cells. Proceedings of the Keystone Symposium on Angiogenesis and Vascular Remodeling, Steamboat Springs, CO, USA. 28 March - 3-April, 1998. 84. Mandriota S.J. and Pepper M.S. Regulation of angiogenesis by interactions between positive and negative regulators. Proceedings of the Keystone Symposium on Angiogenesis and Vascular Remodeling, Steamboat Springs, CO, USA. 28 March - 3 April, 1998. 85. Pepper M.S. Balance and context: regulatory paradigms for angiogenesis. Proceedings of the AACR and APMIS meeting on Proteases and Protease Inhibitors in Cancer, Nyborg Strand, Denmark. 14-18 June, 1998. 86. Mandriota S.J and Pepper M.S. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Proceedings of the Xth International Vascular Biology Meeting, Cairns, Australia. 23-27 August, 1998. 87. Bochaton-Piallat M.-L., Gabbiani G. and Pepper M.S. Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Proceedings of the Xth International Vascular Biology Meeting, Cairns, Australia. 23-27 August, 1998.

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88. Sleeman J. P., Steffen A., Mandriota S.J., Krishnan J. and Pepper, M.S. Lymphangiogenic factors VEGFC and VEGF-D are expressed by tumors. Proceedings of the 5th Franz Volhard Symposium entitled “Twigs and Branches - Tube Formation and Branching in the Cardiovascular System", Berlin (Germany), 3-6 September, 1998. 89. Pepper M.S. Angiogenesis and mechanisms of vesselwall assembly. Proceedings of the 5th International Local Drug Delivery meeting and cardiovascular course on Radiation and molecular strategies, Geneva, Switzerland. 31 January - 2 February, 1999. 90. Gabbiani G., Pepper M.S. and Bochaton-Piallat M.-L. Molecular and cellular mechanisms: plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Proceedings of the 5th International Local Drug Delivery meeting and cardiovascular course on Radiation and molecular strategies, Geneva, Switzerland. 31 January - 2 February, 1999. 91. Quinodoz P., Pittet B., Rinsch C., Aebischer P., Montandon D. and Pepper M.S. Local delivery of bFGF by encapsulated transfected C2C12 myoblasts improves skin flap survival in the rat. Proceedings of the 12th Congress of the International Confederation for Plastic, Reconstructive and Aesthetic Surgery. San Francisco, CA, U.S.A. 27 June - 2 July, 1999. 92. Quinodoz P., Pittet B., Pepper M.S., Rinsch C., Aebischer P. and Montandon D. Local delivery of bFGF by encapsulated transfected C2C12 myoblasts improves skin flap survival in the rat. Proceedings of the 2nd European appointed 35th National Congress of the Swiss Society of Plastic Surgery under the patronage of ESPRAS. St. Gallen, Switzerland. 2-4 September, 1999. 93. Alizadeh N., Pepper M. and Pittet B. Skin flap ischemia: a morphological and physiological study in the rat. Proceedings of the 2nd European appointed 35th National Congress of the Swiss Society of Plastic Surgery under the patronage of ESPRAS. St. Gallen, Switzerland. 2-4 September, 1999. 94. Tacchini-Cottier F., Ody C., Sabapathy K., Belin D., Wagner E.F. and Pepper M.S. The PA/plasmin system in PymT-induced vascular tumor formation. Les Diablerets, Switzerland. 4-9 September, 1999. 95. Alizadeh N., Pepper M.S., Montandon D., Bochaton-Piallat M.L., Gabbiani G., and Pittet B. L‟impact de l‟ischémie sur la cicatrisation. Proceedings of the Journée des jeunes plasticiens of the Société Francaise de Chirurgie Plastique Réconstructrice et Esthétique. Paris, France. 20 January, 2001. 96. Alizadeh N., Pittet B., Pyke C., Montandon D., Ezban M., and Pepper M.S. Le FVIIai améliore la survie des lambeaux cutanés. Proceedings of the Journée des jeunes plasticiens of the Société Francaise de Chirurgie Plastique Réconstructrice et Esthétique. Paris, France. 20 January, 2001. 97. Pepper M.S. Cytokine regulation of vascular tree formation. Proceedings of the 7th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva, Switzerland. 25-27 January, 2001. 98. Mandriota S.J., Jussila L., Jeltsch M., Compagni A., Baetens D. Prevo R., Banerji S., Huarte J., Montesano R., Jackson D., Orci L., Alitalo K., Christofori G. and Pepper M.S. VEGF-C-mediated lymphangiogenesis promotes tumour metastasis. Proceedings of the 3rd Symposium on the Biology of Endothelial Cells. Giessen, Germany. 24-26 May, 2001. 99. Alizadeh N., Pittet B., Pyke C., Baetens D., Montandon D., Ezban M. and Pepper M.S. Inactivated factor VII (FVIIai) increases viability of random skin flaps. An experimental study. Proceedings of the 12th Annual Meetng of the European Association of Plastic Surgeons. Helsinki, Finland. 31 May - 2 June, 2001. 100. Pittet B., Quinodoz P., Alizadeh N., Schlaudraff K., Montandon D. and Pepper M. How can we help acute ischemic tissue to survive? Physiopathological study of the onset of tissular necrosis in an ischemic falp

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model in the rat. Proceedings of the 37ème Congrès Annuel de la Société Suisse de Chirurgie Plastique, Reconstructive et Esthétique. Geneva, Switzerland. 7-8 September, 2001. 101. Schlaudraff K., Pepper M., Ehrenburg I.O., Tkatchouk E.O., Montandon D. and Pittet B. Improvement of the survival of ischemic dorsal skin flaps in the rat by means of normobaric intermittent hypoxia training. Proceedings of the 37ème Congrès Annuel de la Société Suisse de Chirurgie Plastique, Reconstructive et Esthétique. Geneva, Switzerland. 7-8 September, 2001. 102. Alizadeh N., Pepper M.S., Montandon D., Bochaton-Piallat M.L., Gabbiani G. and Pittet B. Impact of persistent lower limb ischemia on wound healing. Proceedings of the 37ème Congrès Annuel de la Société Suisse de Chirurgie Plastique, Reconstructive et Esthétique. Geneva, Switzerland. 7-8 September, 2001. 103. Alizadeh N., Pepper M.S., Montandon D., Bochaton-Piallat M.L., Gabbiani G. and Pittet B. Impact of persistent lower limb ischemia on wound healing. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001. 104. Pittet B., Rinsch C., Quinodoz P., Baetens D., Alizadeh N., Schlaudraff K.U., Montandon D., Aebischer P. and Pepper M.S. Tissue necrosis and its modulation by local release of cytokines in a rat ischemic skin flap model. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001. 105. Schlaudraff K.U., Pepper M.S., Montandon D. and Pittet B. Normobaric intermittent hypoxia training increases the survival of ischemic random dorsal skin flaps in the rat. Proceedings of the 5 th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001. 106. Alizadeh N., Pittet B., Pyke C., Baetens D, Montandon D., Ezban M. and Pepper M.S. Active-site inactivated FVIIa (FVIIai) increases survival in a rat ischemic skin flap model. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001. 107. Pepper M.S. and Wernert N. VEGF-C-mediated lymphangiogenesis promotes tumor metastasis. Proceedings of the PALM AG MicroLaser Systems workshop on laser microdissection technology. Bernried, Germany, 15-16 November, 2001. 108. Pepper M.S. Angiogenesis and vessel wall assembly. Proceedings of the 8th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva, Switzerland, 31 January – 2 February, 2002. 109. Pepper M.S. Cell-based delivery of angiogenic growth factors. Proceedings of the 8th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva, Switzerland, 31 January - 2 February, 2002. 110. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the meeting on Angiogenesis: basic mechanisms and therapeutic implications. Monte Verita (Ascona), Switzerland, 2-7 June, 2002. 111. Pepper M.S. Lymphangiogenesis and tumour metastasis. Proceedings of the Novartis Foundation (prev. Ciba Foundation) Symposium no. 256 on Inflammation and Cancer. London, U.K., 11-14 November, 2002. 112. Schlaudraff K.U., Pepper M., Ehrenburg I., Tkatchouk E., Montandon D. and Pittet B. Intracutaneous oxygen concentration in normal and ischemic skin is increased after intermittent hypoxia training. Proceedings of the 13th International Hypoxia Symposium. Banff Mountain Centre, Banff, Alberta, Canada, 19-22 February, 2003. 113. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the 35th Annual Meeting of the Swiss Societies for Experimental Biology. Davos, Switzerland, 19-21 March, 2003.

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114. Bochaton-Piallat M.L., Hao H., Verin V., Camenzind E., Pepper M.S., Gabbiani G. Porcine coronary artery smooth muscle cells are phenotypoically heterogenous. Proceedings of the 4 th Annual AHA Conference on Atherosclerosis, Thrombosis and Vascular Biology. Washington DC, USA, 8-10 May, 2003. 115. Schlaudraff K.-U., Pepper M., Ehrenburg I.V., Tkatchouk E.N., Montandon D., Pittet B. Impact of intermittent hypoxia training on intracutaneous oxygen concentration in normal and ischemic skin. Proceedings of the 5th International conference on “Hypoxia in Medicine”. Innsbruck, Austria, 26-28 September 2003. 116. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the 2nd Institut Pasteur Euroconference on Angiogenesis. Paris, France, 19-20 June, 2003. 117. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the International Meeting on Angiogenesis in Cancer. Reykjavik, Iceland, 26-28 June, 2003. 118. Podograbinska S., Braun P., Velasco P., Kloos B., Pepper M.S. and Skobe M. Molecular characterization of lymphatic endothelial cells. Proceedings of the International Meeting on Angiogenesis in Cancer. Reykjavik, Iceland, 26-28 June, 2003. 119. Schlaudraff K.U., Pepper M., Ehrenburg I.V., Tkatchouk E.N., Montandon D., Pittet B. Modulation of intracutaneous oxygen concentration by intermittent hypoxia training : implications for flap survival. Proceedings of the 7th European Conference of Scientists and Plastic Surgeons. Geneva, Switzerland, 1920 September, 2003. 120. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the 69. Jahresversammlung Schweizerische Gesellschaft für Pathologie. Ittingen, Switzerland, 6-8 November, 2003. 121. Pepper M.S. Métastases lymphogènes des tumeurs digestives. Proceedings of the Journées medicochirurgicales d‟hépatologie et de gastroenterologie. Geneva, Switzerland, 27-28 November, 2003. 122. Mahajan A.L., Tenorio X., Schlaudraff K.U., Pepper M.S., Baetens D., Montandon D. and Pittet B. New therapeutic intervention with rNAPc2 curbs progression of the burn wound. Poceedings of the XXIXth Sir Peter Freyer Meeting, Galway, Ireland. 3 September, 2004. 123. Pepper M.S. Genes guide the way - a promise of new technology. Proceedings of the Roche In Vitro Diagnostics Forum. Johannesburg (South Africa). 4 October, 2004. 124. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the Autumn meeting of the Belgian Society for Cell and Developmental Biology. Liège (Belgium). 16 October, 2004. 125. Henrichot E., Juge-Aubry C.E., Nisato R., Wohlwend A., Pernin A., Velebit V., Pepper M.S., Meda P. and Meier C.A. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Proceedings of the Société Suisse d'Endocrinologie et Diabétologie, Bern, Switzerland. November 2004. 126. Alizadeh N., Pepper M.S., Alfo K., Montandon D., Gabbiani G., Bochaton-Piallat M.-L. and Pittet B. Persistent ischemia impairs myofibroblast development in wound granulation tissue. A new model of delayed wound healing. Switzerland. November 2004. 127. Tenorio X., Schlaudraff K.-U., Pittet B., Baetens D. and Pepper M.S. Application of rNAPc2 reduces secondary aggravation of burn wounds. Proceedings of the 49th Congrés nationale de la société francaise de chirurgie plastique reconstructice et esthétique. Paris, France. 22-24 November, 2004.

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128. Tenorio X., Schlaudraff K.-U., Pittet B., Baetens D. and Pepper M.S. Application of rNAPc2 reduces secondary aggravation of burn wounds. 41ème Congrès annuel de la société suisse de chirurgie plastique, reconstructrice et esthétique. Bienne, Switzerland. 30 September - 1 October, 2004. 129. Mahajan A.L., Tenorio X., Schlaudraff K.U., Pepper M.S., Baetens D., Montandon D. and Pittet B. Progressive tissue injury in burns is reduced by rNAPc2. Poceedings of the British Association of Plastic Surgeons Meeting, London, UK. December, 2004. 130. Tenorio X, Schlaudraff K.-U., Mahajan A.L., Pepper M.S., Montandon D., Pittet P. Application of rNAPc2 reduces secondary aggravation of burn wounds. 8th European Conference of Scientists and Plastic Surgeons (ECSAPS). Munich (Germany). 15-16 October, 2004. 131. Mathe Z., Dupraz P., Zbinden M., Bosco D., Bucher P., Rinsch C., Thorens B., Berney T. and Pepper M.S. VEGF-A overexpression improves islet cell revascularization and glycemic control after transplantation. American Transplant Congress, Seattle (WA, USA). May, 2005. 132. Mahajan A.L., Schlaudraff K.U., Tenorio X., Pepper M.S., Baetens D., Montandon D. and Pittet B. Progressive tissue injury in burns is reduced by rNAPc2. Proceedings of the British Burns Association (BBA) meeting, York, UK, April 2005. 133. Pepper M.S. Genes guide the way – the promise of new technology. Proceedings of the In Vitro Diagnostics Forum, Athens (Greece), 8-10 June 2005. 134. Mabeta P., Davis P.F. and Pepper M.S.: In vitro inhibition of angiogenesis by interferon alpha and bleomycin. Nature Biotechnology Winter Symposium on Angiogenesis in Cancer and Vascular Disease. Miami Beach, Florida (USA) 4-8 February 2006. 135. Schlaudraff K.-U., Mahajan A.L., Tenorio X., Pepper M.S., Montandon D. and Pittet B. Secondary aggravation of burn wounds and its detrimental influence on post burn sequelae – an underestimated clinical phenomenon? Abstract submitted for the EURAPS-meeting 2006. 136. Pepper MS. The genetics of obesity. Proceedings of the 44th Annual Congress of the South African Gastroenterology Society. Post Elizabeth, South Africa. August 6-9, 2006. 137. Nisato R.E., Tille J.-C., Baetens D., Sutter E., Orci L., Pytowski B. and Pepper M.S. Role of VEGFRs -1, 2 and -3 in VEGF-C-induced lymphangiogenesis and in lymphatic-mediated metastases in Rip1Tag2:Rip1VEGF-C mice. Proceedings of the Gordon Research Conference on "Molecular Mechanisms In Lymphatic Function & Disease", Les Diablerets, Switzerland. 3-8 September, 2006. 138. van der Merwe M.T., Logan M., Pieters J.H., Sammi Y. and Pepper M.S. Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. 15th European Congress on Obesity, Budapest, Hungary. April 22-25, 2007. 139. van der Merwe M.T., Logan M., Pieters J.H., Sammi Y., Pepper M.S. Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. 42nd SEMDSA Congress. Bloemfontein, South Africa. 30 June – 2 July, 2007. 140. Hochfeld W., Asfaha S., Durandt C. and Pepper M.S. Utilization of the Roche Amplichip Platform For Pre-Prescription Genotyping. The 2007 University of Pretoria, School of Medicine, Faculty of Health Sciences Basic Sciences Research Day. Pretoria, South Africa. 15 August 2007. 141. Hochfeld W., Asfaha S., Durandt C. and Pepper M.S. Utilization of the Roche Amplichip Platform For Pre-Prescription Genotyping. The 2007 Pharmacology and Toxicology Congress, The South African Pharmacology Society (SAPS). North West Province, South Africa. 2-5 October 2007. 142. Mabeta P. Pepper M.S. The effect of Paclitaxel on neovessel formation in vitro. 35 th PSSA congress, Muldersdrift, South Africa, 9-12 September 2007.

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143. Mabeta P. Pepper M.S. Induction of in vitro angiogenesis in bovine endothelial cells and the effect of Paclitaxel on neovessel formation. Faculty Day, Faculty of Veterinary Sciences, University of Pretoria, 3 rd September 2007. 144. Mabeta P., Davis P.F. and Pepper M.S.: Assessment of the effects of bleomycin on human haemangioma and angiogenesis in vitro. Faculty Day, Faculty of Health Sciences, University of Pretoria, 15 th August 2007. 145. Dodgen T., Hochfeld W., Asfaha S., Durandt C. and Pepper M.S. Utilization of the Roche Amplichip platform for pre-prescription genotyping. 20th Biennial South African Genetics Society (SAGS) Congress. Pretoria, 27-29 March, 2008. 146. Mabeta P. and Pepper M.S. 2-Methoxyestradiol inhibits angiogenesis in vitro. 46th Annual Conference of the Microscopy Society of Southern African. Gaborone, Botswana, 23-25 July 2008. 147. Dodgen T.M., Cromarty A.D. and Pepper M. Phenotyping of CYP450-mediated drug metabolism in a demographically representative sample of the South African population. ChromSAAMS (Chromatography and Mass Spectrometry Divisions of the South African Chemical Institute), Bela Bela, South Africa. 12-15 October 2008. 148. Pepper M.S. Stem cells: current reality and future promise. International Physiotherapy Congress. Pretoria, South Africa. 6-8 October, 2008. 149. Skeen M. and Pepper M.S. Stem cell therapy for spinal cord injury – a retrospective analysis of patients in South Africa. 7th South African Symposium on Haematopoietic Stem Cell Transplantation. Johannesburg, South Africa. 30-31 January, 2009. 150. Thompson D and Pepper M.S. Flow cytometric analysis of stem cells derived from umbilical cord blood in South Africa. 7th South African Symposium on Haematopoietic Stem Cell Transplantation. Johannesburg, South Africa. 30-31 January, 2009. 151. Flister M.J., Wilber A., Hall K.L., Iwata C., Miyazono K., Nisato R.E., Pepper M.S., Zawieja D.C and Ran S. VEGFR-3 and Prox1 are elevated by NF-kB during inflammatory angiogenesis. 100th Annual Meeting of the American Association for Cancer Research. Denver (CO), USA. 18-22 April, 2009. 152. Mabeta P. and Pepper M.S. Bleomycin inhibits angiogenesis and induces apoptosis in cultured bovine microvascular endothelial cells. 17th Conference of the International Federation of Associations of Anatomists (IFAA), Cape Town, South Africa, 16-19 August 2009. 153. Dodgen T.M, Cromarty A.D. and Pepper M.S. Pre-prescription genotyping of CYP2D6 and CYP2C19 in a demographically representative group of the South African population. Faculty Day, Faculty of Health Sciences, University of Pretoria, 19 August 2009. 154. Eloff A., van Staden C.W., Dodgen T.M., Mataboge C., Roos J.L. and Pepper M.S. Cytochrome P450 2D6 Polymorphisms in Weight Gain and Movement Disorders Associated with Risperidone: A Pilot Study. Faculty Day, Faculty of Health Sciences, University of Pretoria, 19 August 2009. 155. Dodgen T.M., Cromarty A.D., Fickl H. and Pepper M.S. Genotype vs. phenotype and the allelic variation of CYP2D6 and CYP2C19 in a demographic sample of the South African population. International Congress on Pharmaceutical and Pharmacological Sciences, North-West University, 23-26 September 2009. 156. Pepper M.S. Sustainability strategies in public cord blood banking. 31st South African National Blood Transfusion Congress, Johannesburg, 15-18 November 2009.

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157. Mabeta P., Sosibo N., Tshikhudo R. and Pepper M.S. Nanoparticle-based chemotherapy inhibits tumourassociated angiogenesis in a murine vascular tumour model. International Conference on Drug Discovery and Therapy, Dubai, UAE. February 1st - 4th, 2010. 158. Skeen M., Eksteen C. and Pepper M.S. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. Neuroscience Day, University of Pretoria, South Africa. 26 May 2010. 159. Potgieter M., Pretorius R. and Pepper M.S. The effect of antioxidant supplementation in dysferlindeficient muscular dystrophy mice. Neuroscience Day, University of Pretoria, South Africa. 26 May 2010. 160. Skeen M., Eksteen C. and Pepper M.S. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. 49th International Spinal Cord Society (ISCoS) Meeting, New Delhi, India. 29-31 October 2010. 161. Alessandrini M., Dodgen T., Asfaha S. and Pepper M. Genetic and phenotypic variation of CYP450 enzymes in African populations. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010. 162. Dodgen T.M., Drögemöller B.I., Wright G.E.B, Warnich L., Cromarty A.D and Pepper M.S. Pharmacogenetics of CYP2C19 for personalizing medication in the South African population. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010. 163. Potgieter M., Pretorius E., Beukes M. and Pepper M. The effect of antioxidant supplementation in dysferlin-deficient muscular dystrophy mice. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010. 164. Skeen M.C., Eksteen C. and Pepper M. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010. 165. Myburgh R., Salmon P., Sorce S., Hirschel B., Pepper M.S. and Krause K.-H. HIV gene therapy by CCR5 knockdown using multiple short hairpin RNAs. 4ème journée de l'innovation, Hôpitaux universitaires de Genève. Geneva (Switzerland), 13 October 2010. 166. Alessandrini M., Asfaha S.M., Dodgen T.M., Warnich L. and Pepper M.S. Genotypic and Phenotypic Variability Related to CYP450 Metabolism in African Populations. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011. 167. Dodgen T.M., Drögemöller B.I., Wright G.E.B, Warnich L., Fickl H., Steffens F.E., Cromarty A.D and Pepper M.S. Evaluation of CYP2C19 genotype and phenotype in a representative sample of the South African population. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011. 168. Dodgen T.M., Labuschagne C.D.J, van Schalkwyk A., Fickl H., Cromarty A.D. and Pepper M.S. Evaluation of CYP2D6 genotype and phenotype in a representative sample of the South African population. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011. 169. Dodgen T.M., Eloff A., Mataboge C., Roos J.L., van Staden C.W., Pepper M.S. Risperidone-associated adverse drug reactions and Cytochrome P450 2D6 polymorphisms: a pilot study Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011. 170. Logan M.G., van der Merwe M-T., Myburg R., Eloff A., Rheeder P. and Pepper M.S. Melanocortin 4 receptor (MC4R) polymorphisms in a South African study group. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.

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171. Barmania F., Potgieter M. and Pepper MS. Analysis of CCR5 expressing CD4 cells and mutations in the CCR5 gene in African and Caucasian South African population groups. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011. 172. Potgieter M., van Vollenstee F., Kallmeyer K., Dessels C., Jackson C. and Pepper M.S. Human mesenchymal stem cells: isolation, characterization and differentiation. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011. 173. Rangaka I., Alessandrini M. and Pepper M.S. Economic feasibility for establishing a public cord blood stem cell bank in South Africa. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011. 174. Meissner-Roloff M., Young W., Mellet J., Rangaka I. and Pepper M.S. Establishing a public human umbilical cord blood stem cell bank – a pilot study. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011. 175. Mabeta P. and Pepper M.S. Suppression of Akt activity and bcl-2 expression is associated with the inhibition of hemangiomagenesis. International Symposium on Anti-Angiogenic Therapy. San Diego, CA, February 2, 2012. 176. van Vollenstee F., Jackson C., Hoffmann D., Kallmeyer K., Potgieter M., Durant C. and Pepper M.S. The optimization of GFP positive lentiviral vectors and assessment of the characteristics of transduced mesenchymal stem cells. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012. 177. Rangaka I., Alessandrini M. and Pepper, M.S. Operational model and cost implications for establishing a public cord blood stem cell bank in South Africa. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012. 178. Van Rensburg J., Alessandrini M. and Pepper M. Exploring the accuracy of mutation frequency data for monogenic disorders: the use of metachromatic leukodystrophy as a case and point. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012. 179. Meissner-Roloff M. and Pepper M.S. Establishing a public umbilical cord blood stem cell bank for South Africa: Social feasibility. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012. 180. Alessandrini M., Klose K. and Pepper M.S. University entrepreneurship in South Africa: results from a national survey of technology transfer practices. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012. 181. Potgieter M., Durandt C., De Villiers D. and Pepper M.S. The effect of light activation on mesenchymal stem cell phenotype. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012. 182. Skeen M., Eksteen C. and Pepper M.S. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. 52nd Annual Meeting of the International Spinal Cord Society, Istanbul, 28-30 October, 2013. 183. De Bruyn K., Potgieter M., De Villiers P. and Pepper M.S. A theoretical probabilistic approach to mesenchymal stem cell proliferation modelling. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013. 184. De Villiers D., Potgieter M., Durandt C. and Pepper M.S. The effect of hydrogen peroxide on the adipogenic differentiation potential of mesenchymal stem cells. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.

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185. Stewart C., van Rensburg J., Alessandrini M., Masekela R., Green R. and Pepper M.S. Minding the gap – addressing the lack of South African cystic fibrosis patient data. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013. 186. Mellet J., Gray C. and Pepper M.S. HLA typing: conventional techniques vs. next generation sequencing. 187. Durandt C., van Vollenstee F., Kallmeyer K., de Villiers D., Honing C., Potgieter M. and Pepper M.S. Novel flow cytometric approach for the detection of adipocyte sub-populations during adipogenesis. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013. 188. Potgieter M., Alessandrini M. and Pepper M.S. Mesenchymal stem cells: the clinical trial landscape. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013. 189. Van Vollenstee F., Gaggia L., Hoffman D., Kallmeyer K., Potgieter M., Coetzee P., Vermeulen M. and Pepper M.S. Evaluation of the PROCLEIX ULTRIO Plus assay for the detection of HIV-1 in umbilical cord- and adipose tissue derived mesenchymal stem cells. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013. 190. Kallmeyer K., van Vollenstee F., Potgieter M. and Pepper M.S. Isolation and characterization of mesenchymal stem cells from human tissues. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013. 191. Alessandrini. M., Beltchev. E., Pool. R. and Pepper M.S. Diagnosis of acute myeloid leukaemia in south Africa by means of microarray technology. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013. 192. Alessandrini M. and Pepper M.S. Defining the need for pharmacogenetic profiling in Africa: A perspective on cytochrome P450. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013. 193. Alessandrini M., Beltchev E., Pool R. and Pepper M.S. AMLprofiler: Evaluation of a novel diagnostic for acute myeloid leukaemia in the South African setting. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013. 194. Alessandrini M., Beltchev E., Pool R. and Pepper M.S. AMLprofiler: Evaluation of a novel diagnostic microarray for acute myeloid leukaemia in the South African setting. Young Researchers Forum, University of the Witwatersrand, South Africa, 5 October 2013.10.19. 195. Mellet, J., Gray C.M. and Pepper M.S. HLA typing: conventional techniques versus next generation sequencing. Young Researchers Forum, University of the Witwatersrand, South Africa, 5 October 2013. 196. Mellet, J., Gray C.M. and Pepper M.S. HLA typing: conventional techniques versus next generation sequencing. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013. 197. Stewart. C., van Rensburg. J., Alessandrini. M., Masekela. R., Green. R. and Pepper M.S. The requirement for a population-specific diagnostic tool for CF in South Africa. Young Researchers Forum, University of the Witwatersrand, South Africa, 5 October 2013. 198. Stewart. C., van Rensburg. J., Alessandrini. M., Masekela. R., Green. R. and Pepper M.S. The requirement for a population-specific diagnostic tool for CF in South Africa. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013. 199. Alessandrini M. and Pepper M.S. Priority Pharmacogenetics for the African continent: a view on cytochrome P450. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.

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200. Van Rensburg J., Alessandrini M. and Pepper M.S. Determining the accuracy of mutation diversity measurements in metachromatic leukodystrophy. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013. 201. Stewart C., Van Rensburg J., Alessandrini M., Masekela R., Green R. and Pepper M.S. The requirement for a population-specific diagnostic tool for CF in South Africa. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013. 202. Mellet J., Gray C.M. and Pepper M.S. HLA typing: Conventional techniques versus next generation sequencing. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013. 203. Alessandrini M., Beltchev E., Pool R. and Pepper MS. Implementation of the AMLprofiler microarray for the diagnosis and prognosis of acute myeloid leukaemia in South Africa. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013. 204. Pepper MS. The human genome. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus, Kingston , Jamaica, 22 November 2013. 205. Pepper MS. Stem cells – current reality and future promise. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus, Kingston , Jamaica, 22 November 2013. 206. Durandt C., van Vollenstee F.A., Dessels C., Kallmeyer K., Potgieter M., de Villiers D., Honing C., and Pepper M.S. Novel flow cytometric approach for the detection of adipocyte sub-populations during adipogenesis. XXIX Congress of the International Society for Advancement of Cytometry. Ft Lauderdale, Florida, USA. 17-21 May 2014. 207. Alessandrini M and Pepper M.S. Establishing a public umbilical cord blood stem cell bank for South Africa: an enquiry into public acceptability. 4th Ethics, Human Rights and Medical Law conference at the Africa Health Congress. Gallagher Convention Center. 29 May 2014 208. Van Wyk J., Pepper M.S., van der Walt I. and Honing C. Shepherding data on the way to long term stewardship: Research Data Management at the University of Pretoria: a case study. 12th Southern African Online Information Meeting (SAOIM), June 2014. 209. Kallmeyer K., Van Vollenstee F.A., Durandt C., Potgieter M. and Pepper M.S. Isolation and characterization of mesenchymal stem cells from human tissues.17th World Congress of Basic & Clinical Pharmacology, Cape Town, 13-18 July 2014. 210. Alessandrini M. and Pepper M.S. Priority pharmacogenetics for Africa: establishment of a pan-African initiative. 17th World Congress of Basic and Clinical Pharmacology (WCP2014), Cape Town, South Africa, 13-18 Jul 2014. 211. Dessels C., Alessandrini M. and Pepper M.S. Umbilical Cord Blood Banks: A Perspective. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 212. Jackson C.S., Durandt C., Praloran V., Brunet de la Grange P., and Pepper M.S. Targeting The ARNT Complex With DMOG And Stemregenin 1 Improves the Expansion of Primitive Hematopoietic Cells. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 213. Stewart C., van Rensburg J., Alessandrini M., Masekela R., Green R., Zampoli M., Kerbelker T. and Pepper M.S. Towards A South African Cystic Fibrosis Patient Registry. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.

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214. Kiper I., Dessels C., Pepper M.S. and Durandt C. Comparasion Of Nile Red And Bodipy 493/503 Staining On Quantification Of Lipid Content Of Adipocytes Using Fluorescence Microscopy. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 215. Van Rensburg, J., Alessandrini, M. and Pepper, M.S. Rarefaction and Metachromatic Leukodystrophy: A Unifying Factor in Medical Genetics and Ecological Disciplines. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 216. Theron A.E., Lafanechère L., Pepper M.S., Prudent R., Viallet J., Jackson C., Durandt C. and Joubert A.M. Novel Sulphamiolated Analogues Exhibit Promising In Vitro and In Ovo Anti-Cancer Properties. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 217. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 218. De Bruin K.J.F., Dessels C., De Villiers J.P. and Pepper M.S. Estimation of Cell Counts and Confluency of Adherent Adipose-Derived Stem Cells Using Unstained Phase-Contrast Micrographs. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 219. Kallmeyer K., van Vollenstee F.A., Durandt C., Potgieter M. and Pepper M.S. Differences in Basic Biological Characteristics Exist Between Adipose- and Wharton‟s Jelly-Derived Mesenchymal Stromal Cells. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 220. Alessandrini M., Potgieter M. and Pepper M.S. Mesenchymal Stem Cell Therapy: Overview of Clinical Indications. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 221. Kappala S.S., Alessandrini M., Beltchev E., Matlahko T., Pool R. and Pepper M.S. Evaluation of AMLprofiler Compared to the Standard Diagnostic Procedures in Patients with Acute Myeloid Leukemia. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014. 222. Dessels C., Alessandrini M. and Pepper M.S. Umbilical Cord Blood Banks: A Perspective. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 223. Jackson C.S., Durandt C., Praloran V., Brunet de la Grange P., and Pepper M.S. Targeting The ARNT Complex With DMOG And Stemregenin 1 Improves the Expansion of Primitive Hematopoietic Cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technolgy, Pretoria. 27-31 August 2014. 224. Durandt C., van Vollenstee A., Dessels C., Kallmeyer K., Kiper I., de Villiers D., Honing C., Potgieter M., Hoffman D. and Pepper M.S. A multi-colour flow cytometry approach to quantify various stages during adipocyte differentiation: Comparison between Nile Red & Bodipy 493/503. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 225. De Villiers D., Potgieter M., Durandt C. and Pepper M.S. The effect of induced oxidative stress and antioxidant supplementation on the adipogenic differentiation potential of adipose-derived mesenchymal stem cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 226. Van Vollenstee F.A., Jackson C., Hoffmann D., Kallmeyer K., Potgieter M., Durandt C. and Pepper M.S. Immunophenotypical characterisation and differentiation capacity of transduced human adipose derived mesenchymal stromal cells by optimized GFP positive lentiviral vectors International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.

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227. Van Vollenstee F.A., Gaggia L., Hoffmann D., Kallmeyer K., Potgieter M., Coetzee P.F., Vermeulen M. and Pepper M.S. Establishment of a useful molecular platform to for the detection of HIV-1 in umbilical cord- and adipose tissue-derived mesenchymal stem cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 228. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 229. Mellet J. and Pepper M.S. Constituting a public umbilical cord blood bank in South Africa: Demographics, linguistics, and HLA diversity. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 230. De Bruin K.J.F., Dessels C., De Villiers J.P. and Pepper M.S. Estimation of Cell Counts and Confluency of Adherent Adipose-Derived Stem Cells Using Unstained Phase-Contrast Micrographs. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 231. Kallmeyer K. , van Vollenstee F.A., Durandt C., Potgieter M. and Pepper M.S. Differences in Basic Biological Characteristics Exist Between Adipose- and Wharton‟s Jelly-Derived Mesenchymal Stromal Cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 232. McGillewie L., Jackson C., Pepper M.S. and Durandt C. Does multi-colour flow cytometry allow for the identification of primitive cord blood-derived hematopoietic stem cells, using only surface marker staining? International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 233. Alessandrini M., Potgieter M. and Pepper M.S. Clinical indications for mesenchymal stem cell therapy. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 234. Alessandrini M. and Pepper M.S. Establishment of a sustainable public cord blood stem cell bank for South Africa. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014. 235. Alessandrini M., Krause K-H., Speck R.F., Salman P., Myburg R. and Pepper M.S. Clinical Translation of an HIV Gene Therapy. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland. 236. Myburgh R., Pepper M.S., Speck R.F., Krause K-H. and Salmon P. Improved knockdown of target genes via miRNA. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland. 237. Myburgh R., Pepper M.S., Salman P., Krause K-H. and Speck R.F. Gene engineering an HIV resistant immune system. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland. 238. Speck R., Hirschel B., Krause K-H., Salmon P., Myburgh R. and Pepper M. TGT: cure HIV through engineering of an HIV-resistant immune system. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland. 239. Mabeta P., Davis P.F. and Pepper M.S. Vascular specific growth factors in angiogenesis: signaling pathways and therapeutic targeting. 42nd Annual Conference of the Physiology Society of Southern Africa, Durban, South Africa, 14-17 Sept 2014.

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240. Kappala S., Alessandrini M., Beltchev E., Matlahko T., Pool R. and Pepper M.S. AMLprofiler: A novel diagnostic tool for patients with acute myeloid leukemia in South Africa. UNIPATH 2014 (Unifying Pathology and Laboratory Medicine in the Era of P4 Medicine), CSIR International Convention Centre, Pretoria, South Africa, 19-21 Sept 2014. 241. Durandt C. and Pepper M.S. Adipose Tissue As An Immunological Active Organ. UNIPATH. CSIR, Pretoria. 19-21 September 2014. 242. Alessandrini M., Kappala S.S., Beltchev E., Matlahko T., Pool R. and Pepper M.S. Diagnostic nd Prognostic Value of AMLprofiler in the South African Context. UNIPATH. CSIR, Pretoria. 19-21 September 2014. 243. Kappala S.S., Alessandrini M., Beltchev E., Matlahko T., Pool R. and Pepper M.S. Evaluation of AMLprofiler Compared to the Standard Diagnostic Procedures in Patients with Acute Myeloid Leukemia. UNIPATH. CSIR, Pretoria. 19-21 September 2014. 244. Jackson C.S. and Pepper M.S. Analyzing techniques to improve the transduction of HSCs. South African Genetics Society Congress. 23-26 September 2014. 245. Alessandrini M., Kappala S., Matlahko T., Beltchev E., Pool R. and Pepper M.S. AMLprofiler. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014. 246. Colic A., Alessandrini M. and Pepper M.S. Pharmacogenetics of CYP2B6, CYP2A6, and UGT2B7 in HIV treatment in African populations. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014. 247. Jackson C.S., Durandt C, de la Grange P.B., Praloran V. and Pepper M.S. Improving the expansion and transduction of primitive hematopoietic stem cells. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.

248. Stewart C., van Rensburg J., Zampoli M., Kerbelker T., Masekela R., Green R. and Pepper M.S. In the blood – Identifying cystic fibrosis mutations in South African patients. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014. 249. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014. 250. Theron A.E., Lafanechère L., Pepper M.S., Prudent R., Viallet J., Jackson C., Durandt C, and Joubert A.M. Novel in silico-designed anti-cancer compounds: from in vitro exploration to potential clinical considerations. 4th World Congress on Cancer Science & Therapy, October 2014. 251. Alessandrini M. and Pepper M.S. Establishment of a public cord blood stem cell bank for South Africa. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014. 252. Dessels C., Alessandrini M. and Pepper M.S. The treatment landscape of umbilical cord blood banks. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014. 253. Jackson C.S., Durandt C., Brunet de la Grange P., Praloran V. and Pepper M.S. Targeting the HIF complex with DMOG and stemregenin 1 mediates the improved expansion of primitive hematopoietic cells. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014. 254. Jackson C.S. and Pepper M.S. Improving lentivirus transduction of primitive HSCs. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.

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255. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014. 256. Mellet J. and Pepper M.S. Constituting a public umbilical cord blood bank in South Africa: Demographics, linguistics, and HLA diversity. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014. 257. Alessandrini M. and Pepper M.S. Establishment of a public cord blood stem cell bank for South Africa Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.