Menopause The Journal of The North American Menopause Society VOLUME 21, ISSUE 5, 2014 Supplemental Digital Content is available in the text.

C ONTENTS Editorials 435 Ovary and unilateral oophorectomy: is having one the same as having two? Douglas N. Brown, MD, FACOG, FACS 437 Vagina dialogues Caroline M. Mitchell, MD, MPH, and Susan D. Reed, MD, MPH 439 Hormone therapy and vasomotor symptoms after the Women’s Health Initiative Sybil L. Crawford, PhD

Original Articles 442 Incidence, time trends, laterality, indications, and pathological findings of unilateral oophorectomy before menopause Shannon K. Laughlin-Tommaso, MD, MPH, Elizabeth A. Stewart, MD, Brandon R. Grossardt, MS, Liliana Gazzuola Rocca, MD, and Walter A. Rocca, MD, MPH Unilateral oophorectomy without a medical indication has been more common on the left side because of surgical preferences and traditions. The long-term consequences of right or left unilateral oophorectomy on timing of menopause, morbidity, and mortality need further study.

(continued) Menopause: The Journal of The North American Menopause Society (ISSN 1072-3714) is published monthly for The North American Menopause Society by Lippincott Williams & Wilkins, 16522 Hunters Green Parkway, Hagerstown, MD 21740-2116. Business and production offices are located at Two Commerce Square, 2001 Market St., Philadelphia, PA 19103. All rights reserved. Printed on acid-free paper. Periodical postage paid at Hagerstown, Maryland, and at additional mailing offices. Copyright * 2014 by The North American Menopause Society. POSTMASTER: Send address changes to Menopause: The Journal of The North American Menopause Society, P.O. Box 1550, Hagerstown, MD 21740.

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450 Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy Rebecca M. Brotman, PhD, MPH, Michelle D. Shardell, PhD, Pawel Gajer, PhD, Doug Fadrosh, MS, Kathryn Chang, RN, Michelle I. Silver, ScM, Raphael P. Viscidi, MD, Anne E. Burke, MD, MPH, Jacques Ravel, PhD, and Patti E. Gravitt, PhD, MS In a cross-sectional study of 87 pre-, peri- and post-menopausal women, a distinct bacterial community state type (termed CST IV-A) with low relative abundance of Lactobacillus spp. was found to be associated with both menopause stage and vulvovaginal atrophy. 459 Use and discontinued use of menopausal hormone therapy by healthy women in Norway: the Hordaland Women’s Cohort study BjLrn Espen Gjelsvik, MD, JLrund Straand, MD, PhD, Steinar Hunskaar, MD, PhD, Ingvild Dalen, PhD, and Elin O. Rosvold, MD, PhD The 2-year incidence of hormone therapy (HT) users has been shown to have decreased by almost 50% after 2002 and symptoms reappear in most women after HT cessation. 469 Validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis-31 in Spanish postmenopausal women Pedro Jose´ Gonza´lez Matarı´n, MHS, Antonio Martı´nez-Amat, PhD, Rafael Lomas-Vega, PhD, Nicola´s Mendoza Ladro´n de Guevara, MD, Esther Dı´az-Mohedo, PhD, Emilio Martı´nez Lo´pez, PhD, Ana Bele´n Padial Garcı´a, BS, and Fidel Hita-Contreras, MD The article presents the Spanish version of the QUALEFFO-31 questionnaire, which has shown high reliability and validity for assessing quality of life in the Spanish postmenopausal population. 477 Does hormone therapy affect blood pressure changes in the Diabetes Prevention Program? Catherine Kim, MD, MPH, Sherita H. Golden, MD, MHS, Shengchun Kong, MS, Bin Nan, PhD, Kieren J. Mather, MD, Elizabeth Barrett-Connor, MD, and Diabetes Prevention Program Research Group In this study reductions in weight through lifestyle changes led to slight but significant reductions in blood pressure compared to placebo. Decreases in blood pressure were observed in women using estrogen therapy as well as in women not using estrogen therapy.

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484 Safety of veralipride for the treatment of vasomotor symptoms of menopause Marcelino Herna´ndez Valencia, MD, PhD, Marı´a de Jesu´s Vega Arias, MD, Cuauhte´moc Celis Gonza´lez, MD, Imelda Herna´ndez Marı´n, MD, Juan Humberto Martı´n Gonza´lez, MD, Enrique Rafael Morcate Campos, MD, ´ lvarez, MD, Marı´a Antonia Basavilvazo Rodrı´guez, MD, Ignacio Morales A Marı´a Antonia Valde´s Vargas, MD, Jose´ Braulio Everardo Otero Flores, MD, Samuel Santoyo Haro, MD, Manuel Cortes Bonilla, MD, Roberto Bernardo Escudero, MD, and Rosalba Alonso Campero, MD The safety profile of veralipride for the treatment of vasomotor symptoms is discussed. 493 Melatonin in perimenopausal and postmenopausal women: associations with mood, sleep, climacteric symptoms, and quality of life Elena Toffol, MD, Nea Kalleinen, MD, PhD, Jari Haukka, PhD, Olli Vakkuri, PhD, Timo Partonen, MD, PhD, and Pa¨ivi Polo-Kantola, MD, PhD In this study postmenopausal women had lower nighttime serum melatonin concentrations than perimenopausal women. 501 Does bone loss begin after weight loss ends? Results 2 years after weight loss or regain in postmenopausal women Nancy L. Von Thun, MS, Deeptha Sukumar, PhD, Steven B. Heymsfield, MD, and Sue A. Shapses, PhD Weight regain does not result in recovery of bone loss that occurs with weight reduction. 509 Utility of obesity indices in screening Chinese postmenopausal women for metabolic syndrome Pengju Liu, BM, Fang Ma, MS, Huiping Lou, MS, and Yanning Zhu, MD Although a variety of indices have been used to assess obesity, which is closely associated with the presence of metabolic syndrome, it is suggested that waist-to-hip ratio and waist-to-height ratio are the best indicators for predicting the presence of metabolic syndrome in Chinese postmenopausal women. 515 Association of GALNT3 gene polymorphisms with bone mineral density in Chinese postmenopausal women: the Peking Vertebral Fracture study Nan Li, MD, Xiran Wang, MD, Yan Jiang, MD, Wenbo Wang, MD, Wei Huang, MD, Xin Zheng, MD, Qiuping Wang, MD, Zhiwei Ning, MD, Yu Pei, MD, Chunlin Li, MD, Min Nie, MD, Mei Li, MD, Ou Wang, MD, Xiaoping Xing, MD, Shuli He, MD, Wei Yu, MD, Qiang Lin, MD, Ling Xu, MD, and Weibo Xia, MD GALNT3 gene polymorphisms were found in the present study to be associated with the bone mineral density of Chinese postmenopausal women. GALNT3 may play a role in genetic susceptibility to osteoporosis.

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522 Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population Jung-A. Pyun, MS, Sunshin Kim, PhD, Nam H. Cho, PhD, InSong Koh, MD, PhD, Jong-Young Lee, PhD, Chol Shin, MD, PhD, and KyuBum Kwack, PhD Genome-wide association studies and epistasis analyses in a Korean population identified that novel polymorphisms and synergistic interactions between candidate genes were significantly associated with age at menarche and age at natural menopause.

Brief Report 530 Polymorphisms within the FANCA gene associate with premature ovarian failure in Korean women Jung-A. Pyun, MS, Sunshin Kim, PhD, Dong Hyun Cha, MD, PhD, and KyuBum Kwack, PhD Genetic variations within Fanconi anemia complementation group A gene were significantly associated with increased risk of premature ovarian failure in Korean women.

Clinical Corner Clinical Article 534 Menopause and sleep Robert R. Freedman, PhD Patient Handout e3 What Midlife Women Should Know About Menopause and Sleep

Review Article 536 Critical review of complementary and alternative medicine use in menopause: focus on prevalence, motivation, decision-making, and communication Wenbo Peng, MMed, Jon Adams, PhD, David W. Sibbritt, PhD, and Jane E. Frawley, MClinSci A review of the prevalence of complimentary and alternative medicine (CAM) use for menopause alongside CAM user’s characteristics, motivations, decision making and communication with healthcare providers.

Letters to the Editor 549

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Erratum 550 Urine melatonin levels are inversely associated with sarcopenia in postmenopausal women: Erratum

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