Male Infertility הכנס השנתי של איל"ה תקצירים

‫הכנס השנתי של איל"ה‬ ‫ תקצירים‬- 2015 Male Infertility Summary title: The effect of Pentoxifylline on fresh and frozen immotile testicular sperm Fir...
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‫הכנס השנתי של איל"ה‬ ‫ תקצירים‬- 2015

Male Infertility Summary title: The effect of Pentoxifylline on fresh and frozen immotile testicular sperm First Name: Esti Last Name: Kasterstein Presentor Kasterstein, E. name: All authors & Author01Name: Kasterstein, E. Institute name: IVF and Infertility unit, Assaf Harofeh Medical Center, Institute1: Tel Aviv University, Israel Author02Name: Strassburger, D. IVF and Infertility unit, Assaf Harofeh Medical Center, Institute2: Tel Aviv University, Israel Author03Name: Komarovsky. D. IVF and Infertility unit, Assaf Harofeh Medical Center, Institute3: Tel Aviv University, Israel Author04Name: Bern, O. IVF and Infertility unit, Assaf Harofeh Medical Center, Institute4: Tel Aviv University, Israel Author05Name: Maslanski B. IVF and Infertility unit, Assaf Harofeh Medical Center, Institute5: Tel Aviv University, Israel Author06Name: Hadari, D. IVF and Infertility unit, Assaf Harofeh Medical Center, Institute6: Tel Aviv University, Israel Author07Name: Raziel, A. IVF and Infertility unit, Assaf Harofeh Medical Center, Institute7: Tel Aviv University, Israel Author08Name: Gidoni, Y. IVF and Infertility unit, Assaf Harofeh Medical Center, Institute8: Tel Aviv University, Israel Author09Name: Barkat, J. IVF and Infertility unit, Assaf Harofeh Medical Center, Institute9: Tel Aviv University, Israel Author10Name: Ron-El, R.

‫הכנס השנתי של איל"ה‬ ‫ תקצירים‬- 2015

Male Infertility Institute10:

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IVF and Infertility unit, Assaf Harofeh Medical Center, Tel Aviv University, Israel

Sperm motility is crucial for good results in IVF. It is important to distinguish between immotile viable and non viable sperm. Several techniques are used during intracytoplasmic sperm injection (ICSI) procedure to detect motile sperm. Among them, pentoxifylline (PTX) which is a methylxanthine derivative, a non specific phosphodiesterase inhibitor which is associated with improved motility both in fresh and cryopreserved sperm. To evaluate the clinical contribution of PTX addition to the medium before sperm selection for ICSI. The study was carried on 26 azoospermic patients with completely immotile sperm achieved by testicular sperm extraction (TESE). In 16 patients PTX (SIGMA) was added to droplets containing sperm (study group) and 12 patients comprised the control group without PTX. The groups were subdivided into fresh and frozen testicular sperm. In 14 of 16 patients PTX improved sperm motility and motile sperm were injected. In two patients motile sperm were not available; although PTX was used immotile sperm were injected. The 14 patients were divided into fresh and frozen TESE, each of 7 patients, and were compared to 3 and 9 control patients respectively. In the Fresh TESE group, fertilization rates were comparable between study and control groups (37/79; 43% and 9/24; 37.5% respectively). Embryo quality was not significantly different. One pregnancy was achieved among the 7 patients in PTX+ whereas none in the control (0/3). In the Frozen TESE, fertilizations were significantly higher with PTX+ (28/54; 52% and 18/70; 26% respectively) but embryo quality was comparable. Two pregnancies were achieved among 7 patients in PTX+ whereas no pregnancy in the control (0/9). One of the two patients in whom PTX had no influence on sperm motility (PTX-) conceived. Although it seems that PTX has an effect on sperm motility, it was significantly proven only in cases where frozen testicular sperm was used. Whether PTX has an impact on pregnancy rate has still to be clarified.

‫הכנס השנתי של איל"ה‬ ‫ תקצירים‬- 2015

Male Infertility Summary title: Improved Treatment of Psychogenic Anejaculation for Ultra Orthodox Men First Name: Dov Last Name: Popper Presentor Popper D. name: All authors & Author01Name: Popper D. Institute name: Institute1: Puah Institute Author02Name: Weitzman GA Institute2: Puah Institute

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Some ultra-Orthodox Jewish men have trouble ejaculating due to psychogenic inability to epxerience orgasm. Penile vibratory stimulation can induce ejaculation for men with spinal cord injuries. To-date, only anecdotal evidence of effectiveness has been reported in men with psychogenic anejaculation. Our objective was to determine the effectiveness of penile vibrator stimulation (PVS) as primary therapy for psychogenic anejaculation in this population and to develop the best counseling method for such men. To determine whether using PVS could solve the problem of anejaculation without needing to resort to ART. Retrospective chart review of fifty one married Orthodox Jewish men with psychogenic anejaculation who were treated at a counseling center in Jerusalem with instruction and application of penile vibratory therapy. All participants had nocturnal emissions. All men were counseled regarding the treatment of PVS and agreed to use the device in their home setting. None refused the use of the PVS. All couples were provided a PVS device with instructions and agreed to follow up. All thirty four men (mean age = 25.6 years) were married, and the mean duration of marriage was 3.8 years. Of the fifty one men, 60.7% (31/51) were able to ejaculate using the device. Of the men who were able to achieve ejaculation after using the vibrator 58% (18/31) were able to subsequently achieve ejaculation with sexual intercourse. Mean length of follow up was 4 months. Penile vibrator stimulation is an effective way of initiating ejaculation and can be used to overcome the psychological block associated with

‫הכנס השנתי של איל"ה‬ ‫ תקצירים‬- 2015

Male Infertility psychogenic anejaculation enabling such patients to learn to achieve ejaculation without using the device. Optimization of the approach and technique for PVS in this population of patients has yet to be done. Once ejaculation has been achieved, men appear to be able to ejaculate vaginally without reliance on the device and their response appears to be durable.

‫הכנס השנתי של איל"ה‬ ‫ תקצירים‬- 2015

Male Infertility Summary title: Sperm functions tests in infertile men with varicocele and normal fertile men First Name: Ohad Shoshani Last Name: Breitbart Haim Presentor Haim Pinkas name: All authors & Author01Name: Ohad Shoshani Institute name: Department of Urology, Rabin Medical Center, Institute1: Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Author02Name: Haim Pinkas Male Infertility & Sperm Bank, Helen Schneider Hospital for, Women, Rabin Medical Center, Beilinson Institute2: Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Author03Name: Anat Stein Male Infertility & Sperm Bank, Helen Schneider Hospital for, Women, Rabin Medical Center, Beilinson Institute3: Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University Author04Name: Breitbart Haim Mina & Everard faculty of Life Science, Bar-Ilan Institute4: University

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Male factor contributes about 50% for all couples causes of infertility. Varicocele, defined as abnormally dilated veins of the pampiniform plexus draining the testis with reversal blood flow is one of the most common, treatable cause affecting male fertility. Its incidence in the general population is 15%, and increases up to about 40% and 80% in men with primary and secondary infertility, respectively. Although the pathophysiology of varicocele and its relationship with male infertility has been extensively studied for the past 55 years, the mechanisms by which a varicocele would affect fertility have not yet been satisfactorily explained.

‫הכנס השנתי של איל"ה‬ ‫ תקצירים‬- 2015

Male Infertility Aim:

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To study the effect of clinical varicocele (grade 2 & 3) on sperm dynamic functions tests; capacitation and acrosome reaction (AR) spontaneous and induced, in infertile men with abnormal sperm Two groups of healthy men were compared: Study group of 10 infertile men with clinical varicocele, abnormal sperm parameters and no other known causes for subfertility. Control group of 10 fertile volunteers with normal sperm quality. Both groups undergone a thorough evaluation including: scrotal examination for the presence of varicocele and its grade, hormone levels, scrotal sonography with Doppler, and standard semen analysis at our laboratory. Samples from the same semen were transported to the research laboratory at Bar-Ilan University for the specific sperm functions tests: capacitation and AR. Motility and Hyperactivated motility were assessed 30 minutes after sperm production and 3 hours after capacitation at 370C in capacitation medium in 5% CO2 using CASA. Spontaneous AR was tested at the same time points. The percentage of acrosome reacted sperm determines microscopically on air-dried sperm smears using FITC conjugates Pisum sativum agglutinin. Induced AR tested 1 hour after adding EGF. The median age of the participants is 32 and 35 years in the study and control groups, respectively. (p

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