L-carnitine kinetics in chronic hemodialysis patients: comparison between oral and intravenous supplementation

    Y. Kudoh et al. / Journal of Biochemical and Pharmacological Research, Vol. 2 (2): 117-124, June 2014                                           ...
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Y. Kudoh et al. / Journal of Biochemical and Pharmacological Research, Vol. 2 (2): 117-124, June 2014                                           

 

Research Article

L-carnitine kinetics in chronic hemodialysis patients: comparison between oral and intravenous supplementation Yasuo Kudoh*, Shinya Aoyama, Takaaki Torii, Qijie Chen, Daigo Nagahara, Hiromi Sakata, Akihiko Nozawa Kidney Center, Sapporo South One Hospital, Sapporo, Japan * Corresponding author: Yasuo Kudoh, MD, Kidney Center, Sapporo South One Hospital, S1W13, Chuou-ku, Sapporo, 0600061, Japan. E-mail: [email protected] (Received March 30, 2014; Revised: April 29, 2014; Accepted: May 1, 2014; Published online: May 10, 2014)

Abstract: Introduction: In order to clarify the characteristics of different administration routes and to optimize the dosage, carnitine kinetics was investigated under oral and intravenous supplementation. Methods: Lcarnitine was administered orally (900mg) for 12months, intravenously (1000 mg) for 3months and (500mg) for 3months sequentially in 18 chronic hemodialysis patients. Plasma free and acyl carnitine concentrations were assessed before and after hemodialysis procedure at the end of each administration protocol. The muscle carnitine content was calculated by active transport curve. Results: Plasma free carnitine concentration increased from 22.1±6.9 μM/L to 139.1±40.4 μM/L (900 mg p.o), 280.1±52.2μM/L (1000 mg i.v) and 169.7±25.9 μM/L (500mg i.v) before dialysis procedure. Although acyl/free carnitine ratio decreased significantly after each supplementation method (p

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