YOUR GUIDE TO NOVOLOG®

KN W About how NovoLog® can help you get to A1C goal

Individual results may vary.

Indications and Usage What is NovoLog® (insulin aspart [rDNA origin] injection)? • NovoLog® is a man-made insulin used to control high blood sugar in adults and children with diabetes mellitus.

Important Safety Information

Who should not take NovoLog®? Do not take NovoLog® if: • your blood sugar is too low (hypoglycemia) or you are allergic to any of its ingredients. Please see Important Safety Information throughout this brochure and on pages 14-15. Please also see enclosed Prescribing Information and Patient Information.

Be in the KN OW about

Diabetes

NOVO NORDISK: DEDICATED TO DIABETES CARE As a leader in diabetes, Novo Nordisk is dedicated to improving diabetes care worldwide. Since 1923, Novo Nordisk has offered a broad line of medicines for diabetes, in addition to having created the world’s first prefilled pen device for injections.

WHAT IS DIABETES? When you eat, some of your food is broken down into sugar (also called “glucose”). Sugar travels in your blood to all your body’s cells, where it is needed for energy. A hormone called insulin helps sugar move from your blood into your cells. When you have diabetes • Your pancreas makes little or no insulin, or • Your body prevents the insulin you do make from working right As a result, sugar can’t get into your cells, so it stays in your blood. That’s why your blood sugar gets too high.

There are 2 main types of diabetes Type 1 diabetes • Formerly known as juvenile diabetes, it’s usually diagnosed during childhood • Only 5% to 10% of people with diabetes have type 1 • T he body produces very little to no insulin at all

Type 2 diabetes • Usually diagnosed in adults • 90% to 95% of people with diabetes have type 2 • The body doesn’t make enough insulin or can’t use its own insulin to control blood sugar

TREATING YOUR DIABETES Diabetes changes over time and your medication may need to change with it. This doesn’t mean you have not been doing everything right. It’s just the way diabetes is. And while you can’t always control these changes, you can control the next step you take.

“INTENSIVE,” OR “BASAL-BOLUS,” INSULIN THERAPY In people who do not have diabetes, the body makes low levels of insulin throughout the day. When blood sugar goes up, or “spikes,” such as after a meal, the body reacts by releasing more insulin. To mimic the body’s natural insulin patterns, some people with diabetes use “intensive,” or “basal-bolus,” insulin therapy. This means taking: • A long-acting, or “basal,” insulin once or twice daily to help control blood sugar between meals and when you sleep, and • A “bolus,” or fast-acting, insulin to help control blood sugar spikes that happen at mealtime If you have type 1 diabetes, you can use an insulin pump, which you and your health care provider can program to deliver insulin doses throughout the day and at mealtime.

For more information about Novo Nordisk products for diabetes care, call 1-800-727-6500.

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Your Guide to NovoLog® Whether you have type 1 or type 2 diabetes, or are caring for someone with diabetes, you can use this guide to learn about NovoLog®. NovoLog® is a safe, effective, fast-acting insulin proven to help control blood sugar when you eat. Millions of people with diabetes have taken NovoLog® to help reach their A1C goals since 2001. In fact, NovoLog® is the mealtime insulin health care providers prescribe most. Inside, you will find helpful information about managing diabetes. You’ll also find information about support programs offered through Cornerstones4Care®, which can help make your diabetes care plan easier to follow. With this guide, you’ll have the tools you need to Be in the Know about how NovoLog® can help you. Please talk to your health care provider if you have any questions.

“I want my insulin to fit my lifestyle” -Robert R., Bushkill, PA





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Please see Important Safety Information on pages 14-15 and enclosed Prescribing Information.

Individual results may vary.

Did you know? Type 2 diabetes changes over time and it gets harder to control blood sugar spikes after meals and reach your A1C goal. After you eat, your blood sugar is higher than normal for up to 4 hours. Eating 3 meals a day means your blood sugar could be higher than normal for up to 12 hours, or 50% of your day. NovoLog® helps control blood sugar spikes when you eat.

50

%

NovoLog® can provide 50% to 70% of your required daily insulin when taken with long-acting insulin and 100% if you’re using an insulin pump.

Important Safety Information Before taking NovoLog®, tell your health care provider about all your medical conditions including, if you are: • pregnant, plan to become pregnant, or are breastfeeding. • taking new prescription or over-the-counter medicines, including supplements. Talk to your health care provider about how to manage low blood sugar.

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Be in the KNOW about the benefits of NovoLog® Works fast NovoLog® works fast. Take NovoLog® and eat within 5 to 10 minutes. You don’t have to wait 30 minutes, like you do with regular human insulin.

Analog insulin Insulin is a naturally occurring hormone in your body that helps control blood sugar. People with diabetes don’t make enough insulin or can’t use their own insulin to control blood sugar. NovoLog® is an analog insulin, a newer type of insulin designed to mimic the body’s own insulin.

Low rate of low blood sugar In a study of patients with type 1 diabetes, people taking NovoLog® had fewer nighttime low blood sugar episodes than people taking regular human insulin.

Adjustable dosing NovoLog® stays in step with your activities and mealtimes. You and your health care provider can adjust your NovoLog® dose to your eating, activity, and blood sugar reading. You can also adjust your NovoLog® dose for high or low blood sugar. If you need some help on how to dose, ask your health care provider if the NovoLog® Dosing Tool might be right for you.

Please see Important Safety Information on pages 14-15 and enclosed Prescribing Information.

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Why do I need 2 types of insulin? Basal: You may take a long-acting, or “basal,” insulin at night or in the morning (sometimes both) to help control blood sugar between meals and when you sleep. Bolus: NovoLog® is a fast-acting, or “bolus,” insulin. It helps control your blood sugar spikes when you eat.

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Basal-Bolus: Combines basal insulin and NovoLog®. This therapy closely mimics the way your body’s natural insulin works throughout the day.

I’m already taking insulin once or twice a day. Why add NovoLog®? Remember that diabetes changes over time, making it harder to control blood sugar spikes when you eat. Don’t blame yourself. It’s just how diabetes is. Adding NovoLog® to your diabetes care plan can give you the additional blood sugar control you need at mealtime. Visit novolog.com for additional information.

Important Safety Information How should I take NovoLog®? • Read the Instructions for Use and take exactly as directed. • NovoLog® is fast-acting. Eat a meal within 5 to 10 minutes after taking it. • Know the type and strength of your insulin. Do not change your insulin type unless your health care provider tells you to. • Check your blood sugar levels. Ask your health care provider what your blood sugar levels should be and when you should check them. • Do not share needles, insulin pens, or syringes. You may give or get an infection from another person.

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What is A1C and why is it important? A1C measures your estimated blood sugar over the past 2 to 3 months. It is made up of FPG and PPG. You must control both to reach your A1C goal. Taking NovoLog® at mealtime helps control PPG. Use these guidelines from the American Diabetes Association (ADA) to help see if you’re on the right track. Time

Goals for adults with type 1 or type 2 diabetes

FPG (at least 8 hours since you’ve eaten, usually when you wake up)

70 to 130 mg/dL

PPG (1 to 2 hours after you eat) A1C (tested by your health care provider every 3 months)

Your goals

Less than 180 mg/dL Less than 7%

Adapted from the American Diabetes Association. Standards of medical care in diabetes—2014. Diabetes Care. 2014;37(suppl 1):S14-S80.

Using a blood sugar diary will tell you: • If your insulin or other diabetes medicine is working • How physical activity and the foods you eat affect your blood sugar

“For me it’s about feeling well and getting my numbers down“ -Sherri S., Indianapolis, IN

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Individual results may vary.

When should I test my blood sugar when taking NovoLog®? You and your diabetes care team will decide when and how often to check your blood sugar. Here are some times when you may want to check: • When you wake up (this is called “fasting plasma glucose” or “FPG”) • Before meals or large snacks • 1 to 2 hours after meals (this is called “postprandial plasma glucose” or “PPG”) • Before and within minutes after physical activity The American Diabetes Association (ADA) recommends certain blood sugar goals for adults with diabetes. You can see these listed on the chart on the left.

Important Safety Information What should I avoid while taking NovoLog®? • Do not drive or operate heavy machinery, until you know how NovoLog® affects you. • Do not drink alcohol or use medicines that contain alcohol. Please see Important Safety Information on pages 14-15 and enclosed Prescribing Information.

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NovoLog® delivery options NovoLog® is available in a 10-mL vial, FlexPen®, or in a 3-mL PenFill® cartridge.

NovoLog® FlexPen® NovoLog® FlexPen® is a discreet, prefilled, dial-a-dose insulin pen and is ready to use in just a few steps.a NovoLog® FlexPen® lasts up to 28 days without refrigeration after first use, so it can be taken almost anywhere. Once in use, NovoLog® FlexPen® must be kept at room temperature below 86°F for up to 28 days. Accurate and adjustable dose setting in 1-unit increments

Works with NovoFine® 32G Tip, our thinnest needle available that fits all insulin pens

Prefilled with 300 units of insulin

Enhanced color branding for easy insulin identification

Needles are sold separately and may require a prescription in some states.

How to store NovoLog® No refrigeration once in use Storage for NovoLog® FlexPen®, 3-mL PenFill® cartridge,b and 10-mL vial: Temperature

Storage

In usec,d (opened)

Room temperature (up to 86°F)

28 days

Not in use (unopened)

Room temperature (up to 86°F)

28 days

Not in use (unopened)

Refrigerated

Until expiration date

Please see the enclosed Prescribing Information, which contains full Instructions For Use.

a

b

3-mL PenFill® cartridge is available for NovoPen Echo®.

FlexPen® and PenFill® cartridges in use (opened) should NOT be stored in the refrigerator.

c

d

Vials in use (opened) may be stored in the refrigerator.

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Insulin pumps Many people with type 1 diabetes use an insulin pump. An insulin pump is a small, battery-operated device. Pumps can be programmed to deliver: • Constant “basal” doses of NovoLog® throughout the day, and • “Bolus” doses when you eat NovoLog® has been shown to be safe and effective for use in insulin pumps in children age 2 and older with type 1 diabetes and adults with diabetes. If you use an insulin pump, it’s a good idea to have a backup source for insulin. Ask your health care provider about NovoLog® FlexPen®—or NovoPen Echo®—as an option. If you are using a pump, here’s how often to change NovoLog®: Pump component

Time frame

Reservoir

Up to 6 days

Infusion set and infusion set insertion site

Up to 3 days

NovoLog® remains heat-stable in pumps at normal body temperature (up to 98.6°F).

Important Safety Information What are the possible side effects of NovoLog®? Serious side effects can lead to death, including: Low blood sugar. Some signs and symptoms include: • anxiety, irritability, mood changes, dizziness, sweating, confusion, and headache. Please see Important Safety Information on pages 14-15 and enclosed Prescribing Information.

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NovoPen Echo® The Latest Novo Nordisk Reusable Insulin Pen Designed with your needs in mind. • Records dose and time since last injection for extra reassurance • Delivers the exact dose you need in half-unit dosing from 0.5 to 30 units • Short button travel for reduced injection movement • Choose your style. Available in 12 fun skins!

Visit mynovopenecho.com for more information.

Important Safety Information Your insulin dose may need to change because of: • weight gain or loss, increased stress, illness, or change in diet or level of physical activity. Other common side effects may include: • low potassium in your blood, injection site reactions, itching, rash, serious whole body allergic reactions, skin thickening or pits at the injection site, weight gain, and swelling of your hands and feet and if taken with thiazolidinediones (TZDs) possible heart failure. Get emergency medical help if you have: • trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, or confusion. Please see Important Safety Information on pages 14-15 and enclosed Prescribing Information.

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What else should I be doing? Join Cornerstones4Care® and learn about the 4 cornerstones of diabetes care:





Healthy eating: Balancing what, when, and the amount you eat is key

Being active: Getting active—or getting more active—can make a big difference

 Taking medicine: Keeping track of your medicine for diabetes  Tracking your blood sugar: By writing your daily numbers in a diary, you’ll notice blood sugar patterns and you can plan for them Once you register, you’ll get 24/7 access to an online diabetes support program designed to help you manage your diabetes, your way. You will also have access to the Cornerstones4Care Diabetes Health Coach, which offers a step-by-step, online, personalized learning and action plan to help you build the healthy habits and skills you need to manage your diabetes. ®

Additional Type 1 Diabetes Support— NovoLog® Reach • Support, tools, and information for people of all ages with type 1 diabetes, and those who care for them • Inspirational videos, kid-friendly recipes, and more • Designed with input from people with type 1 diabetes

Visit support.novolog.com to get started.

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Indications and Usage What is NovoLog® (insulin aspart [rDNA origin] injection)? • NovoLog® is a man-made insulin used to control high blood sugar in adults and children with diabetes mellitus.

Important Safety Information Who should not take NovoLog®? Do not take NovoLog® if: • your blood sugar is too low (hypoglycemia) or you are allergic to any of its ingredients. Before taking NovoLog®, tell your health care provider about all your medical conditions including, if you are: • pregnant, plan to become pregnant, or are breastfeeding. • taking new prescription or over-the-counter medicines, including supplements. Talk to your health care provider about how to manage low blood sugar. How should I take NovoLog®? • Read the Instructions for Use and take exactly as directed. •N  ovoLog® is fast-acting. Eat a meal within 5 to 10 minutes after taking it. •K  now the type and strength of your insulin. Do not change your insulin type unless your health care provider tells you to. •C  heck your blood sugar levels. Ask your health care provider what your blood sugar levels should be and when you should check them. •D  o not share needles, insulin pens, or syringes. You may give or get an infection from another person.

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IMPORTANT SAFETY INFORMATION (cont’d) What should I avoid while taking NovoLog®? • Do not drive or operate heavy machinery, until you know how NovoLog® affects you. • Do not drink alcohol or use medicines that contain alcohol. What are the possible side effects of NovoLog®? Serious side effects can lead to death, including: Low blood sugar. Some signs and symptoms include: • anxiety, irritability, mood changes, dizziness, sweating, confusion, and headache. Your insulin dose may need to change because of: • weight gain or loss, increased stress, illness, or change in diet or level of physical activity. Other common side effects may include: • low potassium in your blood, injection site reactions, itching, rash, serious whole body allergic reactions, skin thickening or pits at the injection site, weight gain, and swelling of your hands and feet and if taken with thiazolidinediones (TZDs) possible heart failure. Get emergency medical help if you have: • trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, or confusion.

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Be in the KN W about NovoLog®. Visit NovoLog.com to learn more and join Cornerstones4Care® to pay no more than $25 each fill for up to 2 years (up to $100 off each fill). Eligibility and other restrictions apply. See novolog.com for details.

Covered by most health insurance and Medicare plans. NovoLog® is available by prescription only. Talk to your health care provider about the importance of diet and exercise in your treatment plan. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit fda.gov/medwatch or call 1-800-FDA-1088.

XX% Cert no. XXX-XXX-000

If you need assistance with prescription drug costs, help may be available. Visit pparx.org or call 1-888-4PPA-NOW.

Please see Important Safety Information throughout this brochure and on pages 14-15. Please also see enclosed Prescribing Information and Patient Information.

Cornerstones4Care®, FlexPen®, NovoFine®, NovoLog®, NovoPen Echo®, NovoTwist®, and PenFill® are registered trademarks of Novo Nordisk A/S. © 2014 Novo Nordisk Printed in the U.S.A. 0814-00022758-1 September 2014