Journal of Renin-Angiotensin-Aldosterone System http://jra.sagepub.com/

Aliskiren alleviates doxorubicin-induced nephrotoxicity by inhibiting oxidative stress and podocyte injury Azhar Rashikh, Krishna K Pillai, Shibli J Ahmad, Mohammad Akhtar and Abul K Najmi Journal of Renin-Angiotensin-Aldosterone System 2013 14: 14 originally published online 11 October 2012 DOI: 10.1177/1470320312459980 The online version of this article can be found at: http://jra.sagepub.com/content/14/1/14

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0320312459980Journal of the Renin-Angiotensin-Aldosterone SystemRashikh et al.

Article

Aliskiren alleviates doxorubicin-induced nephrotoxicity by inhibiting oxidative stress and podocyte injury

Journal of the Renin-AngiotensinAldosterone System 14(1) 14­–22 © The Author(s) 2012 Reprints and permission: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1470320312459980 jra.sagepub.com

Azhar Rashikh, Krishna K Pillai, Shibli J Ahmad, Mohammad Akhtar and Abul K Najmi

Abstract Introduction: Doxorubicin (DXR) is one of the most effective and widely used anthracycline antibiotics. However, its clinical application is hampered by toxic effects in many organs. Nephrotoxicity is one of the major side effects of anthracycline antibiotics.This study was designed to investigate the possible protective effects of aliskiren (a direct renin inhibitor) in DXR-induced nephrotoxicity in rats. Materials and methods: Wistar albino rats were intraperitoneally (ip) injected with DXR and renin activity, albumin, total protein, urea, creatinine levels in plasma and ultrastructural changes in podocytes were assessed. Results: Rats subjected to DXR administration had significant (p