J.Neurol.Sci.[Turk]

Journal of Neurological Sciences [Turkish] 28:(2)# 27; 236-242, 2011 http://www.jns.dergisi.org/text.php3?id=433 Research Article A Comparison of the Effects of Adcon-L, Mitomycin C and Sodium Hyaluronate in Experimental Epidural Fibrosis in Rabbits Bülent KAYA1, Hacı Hasan ESEN2, Mehmet Erkan ÜSTÜN3 1

Doğubeyazıt Goverment Hospital, Neurosurgery, Ağrı, Türkiye 2Selçuk University, Pathology, Konya, Türkiye 3Selçuk University, Neurosurgery, Konya, Türkiye

Summary Objective: Epidural fibrosis and leptomeningeal adhesion formation are among the common causes of failed back surgery syndrome. Various materials have been used to prevent the compressive effect of postoperative epidural fibrosis on neural structures. The effects of Adcon L, Mitomycin C and sodium hyaluronate on epidural fibrosis compared in this experimental study. Methods: 28 rabbits divided into 4 different groups. L5 total laminectomy performed under ketamine and xyzlazine anasthesia. Group1 settled as control group and had no medications after laminectomy. Adcon L in group 2, Mitomycin C in group3 and sodium hyaluronate in group 4 were applied to laminectomy area. All groups sacrified 6 weeks after laminectomy. Histologic slices were invastigated under light microscobe according to their histopathological features and the groups were compared. Result: Grade 3 fibrosis determinated in group1. Statistically significant differences between group1 and all other groups were obtained (p