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Journal of Chemical and Pharmaceutical Research

J. Chem. Pharm. Res., 2010, 2(5):379-383 ISSN No: 0975-7384 CODEN(USA): JCPRC5

Antioxidant activity of the hydro-alcoholic extract of Erythrina fusca Lour. bark against the animal models of epilepsy Subal Debnath1*, M. Kannadasan2, Arghya Acharjee2, Chiranjib Bhattacharjee1, Santhosh Kumar. C1, G. Ganesh kumar1, 1

Srikrupa Institute of Pharmaceutical Sciences, Dist. Medak, Siddipet, Andhra Pradesh 2 College of Pharmacy, SRIPMS, Coimbatore, Tamilnadu ___________________________________________________________________________ ABSTRACT The objective of the present study was to evaluate the anti-oxidant activity of the hydroalcoholic extract of the bark of Erythrina fusca Lour (HAEEF) using different in vivo experimental models. Animals are used for the demonstration of an injury by exogenous agents of epileptic seizure on the brain with its physiological significance. Epileptic seizure challenged animals treated with HAEEF at doses of 250 mg/kg and 500 mg/kg showed antioxidant activity. Thus, it can be inferred that the hydro-alcoholic extract of Erythrina fusca Lour bark possess antioxidant effect against the animal models of epilepsy. The malondialdehyde levels were significantly increased in serum and brain tissue, the levels of SOD is significantly decreased in brain tissue and epileptic seizures caused a significant (P