JIANJUN CHENG Materials Science and Engineering University of Illinois at Urbana-Champaign (UIUC) 1304 West Green Street, Urbana, Illinois 61801 Office Phone: 217-244-3924; Fax: 217-333-2736 Email: [email protected] EDUCATION 2001 Ph.D.

1996

M.S.

1993

B.S.

EXPERIENCE 2015 – present 2011 – 2015 2005 – 2011 2015 2011 2005 – present

2010 – present 2004 – 2005 2004 – 2005 2001 – 2004 1997 – 2001 1996 – 1997 1993 – 1996

Materials Science, University of California, Santa Barbara, CA Advisor: Prof. Timothy Deming (currently at Dept. of Bioengineering, UCLA) Dissertation: Controlled synthesis of polypeptide materials Organic Chemistry, Southern Illinois University, Carbondale, IL Advisor: Prof. Gerard Smith Thesis: Heterogeneous catalysts mediated enantioselective hydrogenation of prochiral carbon-carbon double bonds Organic Chemistry, Nankai University, Tianjin, P. R. China Advisor: Prof. Jin-Pei Cheng

Professor, Department of Materials Science and Engineering, UIUC Associate Professor, Department of Materials Science and Engineering, UIUC Assistant professor, Department of Materials Science and Engineering, UIUC Guest Professor, Soochow University, China Molecular Institute, University of Chicago Affiliate, Department of Chemistry, Department of Bioengineering, Institute of Genomic Biology, Beckman Institute for Advanced Studies, Micro and Nanotechnology Laboratory, Materials Research Laboratory, UIUC Member, University of Illinois Cancer Center Consultant of Insert Therapeutics, Inc., Pasadena, CA Postdoctoral associate, Department of Chemical Engineering, MIT Advisor: Prof. Robert S. Langer Senior scientist and project leader, Insert Therapeutics, Inc., Pasadena, CA Research Assistant, University of California, Santa Barbara Advisor: Prof. Timothy Deming (now at UCLA) Teaching Assistant, Chemistry Dept., University of California, Santa Barbara Teaching Assistant, Chemistry Dept, Southern Illinois University, Carbondale

HONORS AND AWARDS 2015 Faculty Entrepreneurial Fellow, UIUC 2015 Distinguished Promotion Award, UIUC (5 out of 80 faculty promoted) 2015 Fellow, American Institute for Medical and Biological Engineering (AIMBE) 2015 Fellow, American Chemical Society-Division of Polymer Chemistry (ACS-POLY) 2014 Associate, Center for Advanced Study, UIUC 2013 Willett Faculty Scholar, UIUC 2011 Tau Beta Pi Eminent Engineer 2010 NIH Director’s New Innovator Award 2010 Xerox Award, UIUC 1

2010 2008-2010 2008 2007 2007 1997 1990-1992

Invitee, Golden Triangle Workshop, President's Innovation and Technology Advisory Committee (PITAC), Washington DC Teacher Ranked Excellent, Center for Teaching Excellence, UIUC (five times) National Science Foundation CAREER Award Prostate Cancer Foundation Competitive Award ACS Petroleum Research Foundation Doctoral New Investigator Award Graduate Division Fellowship, University of California, Santa Barbara, CA Wang Ke-Chang Foundation Fellowship, Nankai University, Tianjin, China

EDITORSHIPS Editorial Board Member, Chinese American Society of Nanomedicine and Nanotechnology Associate Editor, Biomaterials Science, Royal Society of Chemistry, 2012-present Editorial Board Member, Journal of Molecular Biomarkers and Diagnosis, 2010-present Editorial Board Member, BioMed Research International, 2013-present Editorial Board Member, Scientific Reports, Nature Publishing Group, 2014-present Editorial Board Member, Austin Journal of Biotechnology & Bioengineering, 2014-present Invited Editor: PNAS Guest Editor: Biomaterials Science and Current Opinion in Solid State & Materials Science PUBLICATIONS (Citation: 6200; H-Index 36, Google Scholar as of 08/2015) 2015 135. Uckun, F.M.; Mitchell, L.G.; Qazi, S.; Myers, D.E.; Ma, H.; Zheng, N.; Song, Z.; Liu, Y.; Cheng, J. "Development of Polypeptide-Based Nanoparticles for Non-Viral Delivery of CD22 RNA Transsplicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL EBioMedicine", EBioMedicine, 2015, 2, 647–657. 134. Song, Z.; Kim, H.; Ba, X.; Baumgartner, R.; Lee, J.; Tang, H.; Leal, C.; Cheng, J.* "Polypeptide Vesicles with Densely Packed Multilayer Membranes", Soft Matter, 2015, 11, 4091-4098. 133. Baumgartner, R.; Song, Z.; Zhang, Y.; Cheng, J.* "Functional Polyesters Derived from Alternating Copolymerization of Norbornene Anhydride and Epoxides", Polymer Chemistry, 2015, 6, 35863590. 132. Uckun, F.M.; Qazi, S.; Cheng, J.; Myers, D. “Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive Bprecursor Leukemia and Yield Superior Survival Outcomes in Mice”, EBiomedicine, 2015, 2, 554562. 131. Andrade, B.; Song, Z.; Li, J.; Zimmerman, S.C.; Cheng, J.; Moore, J.S.; Harris, K.; Katz, J. "New Frontiers for Encapsulation in the Chemical Industry", ACS Applied Materials & Interfaces, 2015, 7, 6359-6368. 130. Wang, H.C.; Zhang, Y.; Possanza, C.M.; Zimmerman, S.C.; Cheng, J.; Moore, J.S.; Harris, K.; Katz, J.S. " Trigger Chemistries for Better Industrial Formulations", ACS Applied Materials & Interfaces, 2015, 7, 6369-6382. 129. Uckun, F.M.; Qazi, S.; Cheng, J. "Targeting leukemic stem cells with multifunctional bioactive polypeptide nanoparticles", Future Oncology, 2015, 11, 1149-1152. 128. Torabi, S.F.; Wu, P.; McGhee, C.E.; Chen, L.; Hwang, K.; Zheng, N.; Cheng, J.; Lu, Y. "In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing", PNAS, 2015, 112, 5903-5908. 2

127. Lee, J.S.; Deng, X.; Han, P.; Cheng, J." Dual Stimuli-Responsive Poly(β-amino ester) Nanoparticles for On-Command Burst Release”, Macromolecule Bioscience, accepted. 126. Wang, H,; Liu, Y.; Yen, J.; Xu, M.; Yin, Q.; Cheng, J." In Vivo Cancer Targeting via Glycopolyester Micelle Mediated Meta-bolic Cell Labeling Followed by Click Reaction”, Angew Chem., submitted. 125. Yin, Q.; Yin, L.; Wang, H.; Cheng, J. "Synthesis and biomedical applications of functional poly(αhydroxy acids) via ring-opening polymerization of O-carboxyanhydrides”, Acc. Chem. Res., 2015, 48, 1777-1787. 124. Yin, Q.; Tang, L.; Tong, R.; Sternberg R.; Yang, X.; Dobrucki, L.W.; Borst LB; Kamstock, DA; Cai KM; Song, Z.; Helferich, WG; Cheng, J.; Fan, TM "Preclinical Evaluation of Pamidronate Functionalized Doxorubicin-Polylactide Nanoconjugates for Targeted Therapy of Focal Skeletal Malignant Osteolysis.”, Cancer Research, submitted. 123. Xiong, M.; Lee, MW; Song, Z.; Yao, C.; Wong, GCL; Cheng J. “Helical Antimicrobial Polypeptides with Radial Amphiphilicity”, PNAS, accepted. 122. Uckun, F.M.; Ma, H.; Cheng, J.; Myers D.E.; Qazi, S. "CD22DE12 as a molecular target for RNAi therapy", British Journal of Haematology, 2015, 169, 401-414. 121. Cai, K.; He, X.; Song, Z.; Yin, Q.; Zhang, Y.; Uckun, F.M.; Jiang, C.; Cheng, J. "Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency", J. Am. Chem. Soc., 2015, 137, 3458-3461. 120. Tang, L.; Yin, Q.; Xu, Y.; Zhou, Q.; Cai, K.; Yen, J.; Dobrucki, L.W.; Cheng, J. “Bioorthogonal Oxime Ligation Mediated In Vivo Cancer Targeting", Chemical Science, 2015, 6, 2182-2186. 119. Zhang, Y.; Yin, Q.; Yen, J.; Li, J.; Ying, H.; Wang, H.; Hua, Y.; Chaney, E.J.; Boppart, S.A.; Cheng, J. “Non-Invasive, Real-Time Reporting Drug Release In Vitro and In Vivo", Chem. Commun., 2015, 51, 6948-6951. 118. Zheng, N.; Song, Z.; Liu, Y.; Zhang, R.; Zhang, R.; Yao, C.; Uckun, F.M.; Yin, L..; Cheng, J. “Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery", J. Controlled Release, 2015, 205, 231-239. 117. Wang, H.; Xu, M.; Xiong, M.; Cheng, J. "Reduction-Responsive Dithiomaleimide-Based Nanomedicine with High Drug Loading and FRET-Indicated Drug Release", Chem. Commun., 2105, 51, 4807-4810. 116. Cai, K.; Yen, J.; Yin, Q.; Liu, Y.; Song, Z.; Lezmi, S.; Zhang, Y.; Yang, X.; Helferich, W.; Cheng, J. "Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics", Biomaterials Science, 2015, 3, 1061-1065. 115. Ma, L.; Baumgartner, R.; Zhang, Y.; Song, Z.; Cai, K.; Cheng, J. "UV-Responsive Degradable Polymers Derived from 1-(4-Aminophenyl) ethane-1, 2-diol", Journal of Polymer Science, Part A, 2015, 53, 1161-1168. 114. Gauthier, M.; Yin, Q.; Cheng, J.; O'Brien, W. "Design of albumin-coated microbubbles loaded with polylactide nanoparticles", J. Ultrasound Medicine, 2015, 34, 1363-1372. 113. Yin, L.; Chen, Y.; Zhang, Z.; Yin, Q.; Zheng, N.; Cheng, J. "Biodegradable Micelles Capable of Mannose-Mediated Targeted Drug Delivery to Cancer Cells", Macromolecular Rapid Communications, 2015, 36, 483-489. 112. Priftis, D.; Leon, L.; Song, Z.; Perry, S.L.; Margossian, K.O.; Tropnikova, A.; Cheng, J.; Tirrell, M. "Self-assembly of α-helical Polypeptides Driven by Complex Coacervation", Angew Chem. Int. Ed., 2015, accepted. 111. Tang, L.; Tong, T.; Coyle, VJ; Pondenis, H.; Borst, LB; Cheng, J.; Fan, TM. "Targeting Tumor Vasculature with Aptamer Functionalized Doxorubicin-Polylactide Nanoconjugates for Enhanced Cancer Therapy", ACS Nano, 2015, 9, 5072-5081. 3

110. Yin L.; Zheng, N.; Song, Z.; Kim, KH; Zhang Y.; Lu, H.; Yao, C.; Zhang, R.; Tang, H.; Uckun, F.M.; Cheng, J. "Suppression of Hepatic Inflammation via Systemic Delivery of TNF-α siRNA by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles", ACS Nano, submitted. 109. Zhang, R.; Song, Z.; Yin, L.; Lu, H.; Gabrielson, NP.; Cheng, J. "Ionic α-Helical Polypeptides towards Non-Viral Gene Delivery" WIREs Nanomedicine & Nanobiotechnology., 2015, 7, 98100. 2014 108. Qu, Q.; Dong, L.; Louis, K.R.; Li, X.; Yang, H.; Sun, Q.; Crandall, S.R.; Tsang, S.; Zhou, J.; Cox, C.L.; Cheng, J.; Wang, F. "High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1", Nature Communications, 2014, 5, 3449. 107. Ying, H.; Zhang, Y.; Cheng, J. "Dynamic urea bond for the design of reversible and self-healing polymers", Nature Communications, 2014, 5, 3218. 106. Tang, L.; Yang, X.; Yin, Q.; Cai, K.; Wang, H.; Chaudhury, I.; Yao, C.; Zhou, Q.; Kwon, M.; Hartman, J.A.; Dobrucki, I.T.; Dobrucki, L.W.; Borst,. L.B.; Lezmi, S.; Helferich, W.G.; Ferguson, A.L.; Fan, T.M.; Cheng, J. "Investigating the optimal size of anticancer nanomedicine", PNAS, 2014, 111, 15344-15349. 105. Ying H.; Cheng, J. "Hydrolysable Polyureas Bearing Hindered Urea Bonds", J. Am. Chem. Soc.,, 2014, 36, 16974-16977. 104. Uckun, F.M.; Qazi, S.; Ma, H.; Yin, L.; Cheng, J. "A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies", EBioMedicine, 2014, 1, 141-155. 103. Yin, L.; Huang, X.; Xu, H.; Zhang, Y.; Lam, J.; Cheng, J.; Rogers, JA. "Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries”, Advanced Materials, 2014, 23, 3879-3884. 102. Yen, J.; Yin, L.; Wang, F., Cheng, J. "Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells via Small Molecule-Mediated Transient Alteration of Cell Structure" J. Mat. Chem. B., 2014, 2, 8098-8105. 101. Zhang, Y.; Wang, R.; Hua, Y.; Baumgartner, R.; Cheng, J. "Trigger-Responsive Poly(β-amino ester) Hydrogels", ACS Macro Letters, 2014, 3, 693-697. 100. Tong, R.; Tang, L.; Ma, L.; Tu, C.; Baumgartner, R.; Cheng, J. “Smart Chemistry in Polymeric Nanomedicines,” Chemical Society Reviews,. 2014, 43, 6982-7012.. 99. Myers, D.E.; Yiv, S.; Qazi, S.; Ma, H.; Cely, I.; Shahidzadeh, A.; Arellano, M.; Finestone, E.; Gaynon, P.; Termuhlen, A.; Cheng, J.; Uckun, F.M.,“ CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells” Integrative Biology, 2014, 6, 766-780. 98. Zheng, C.; Niu, L.; Pan, W.; Zhou, J.; Lu, H.; Cheng, J.; Liang, D. "Long-term kinetics of DNA interacting with polycations”, Polymer, 2014, 55, 2464-2471. 97. Karimi, M.; Chaudhury, I.; Cheng, J.; Safari, M.; Sadeghi, R.; Habibi-Rezaei, M.; Kokini, J.;" Immobilization of endo-inulinase on non-porous aminofunctionalized silica nanoparticles”, Journal of Molecular Catalysis B: Enzymatic, 2014, 104, 48-55. 96. Deng, X.; Zheng, N.; Song, Z.; Yin, L.; Cheng, J. "Trigger-responsive, fast-degradable poly(βamino ester)s toward non-viral gene delivery: Enhanced DNA unpackaging and reduced toxicity, Biomaterials, 2014, 35, 5006-5015. 95. Song, Z.; Zheng, N.; Ba, X.; Yin, L.; Zhang, R.; Ma, L.; Cheng, J. "Polypeptides with Quaternary Phosphonium Side Chains: Synthesis, Characterization, and Cell-Penetrating Properties", Biomacromolecules, 2014,15, 1491-1497. 4

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Zhang, R.; Zheng, N.; Song, Z.; Yin, L.; Cheng, J. "The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides", Biomaterials, 2014, 35, 3443-3454. 93. Uppada, S.B.; Erickson, T.; Wojdyla, L.; Moravec, D.N.; Song, Z.; Cheng, J.; Puri, N. "Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy", International Journal of Nanomedicine, 2014, 9, 43-53. 92. Lu, H.; Wang, J.; Song, Z.; Yin, L.; Zhang, Y.; Tang, H.; Tu, C.; Lin, Y.; Cheng, J. "Recent Advances in Amino Acid N-Carboxyanhydrides and Synthetic Polypeptides: Chemistry, SelfAssembly and Biological Applications", Chemical Communications, 2014, 50, 139-155. 91. Yin, Q.; Tong, R.; Yin, L.; Fan, T.M.; Cheng, J. "Anticancer Camptothecin-N-Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker", Polymer Chemistry, 2014, 5, 1581-1585. 90. Zheng, N.; Yin, L.; Song, Z.; Ma, L.; Tang, H.; Gabrielson, N.P.; Lu, H.; Cheng, J. "Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting", Biomaterials, 2014, 35:4, 1302-1314. 2013 89. 88.

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Zhang, Y.; Yin, Q.; Yin, L.; Ma, L.; Tang, L.; Cheng, J. "Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability", Angew. Chem. Int. Ed. 2013, 52, 6435-6439. Yin, L.; Song, Z.; Qu, Q.; Kim, KH; Zheng, N.; Yao, C.; Chaudhury, I.; Tang, H.; Gabrielson, NP; Uckun, F.M.; Cheng, J. "Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation ", Angew. Chem. Int. Ed. 2013, 52, 5757-5761. Yin, L.; Tang, H.; Kim, KH.; Zheng, N.; Song, Z.; Gabrielson, NP.; Lu, H.; Cheng, J. "LightResponsive Helical Polypeptides Capable of Reducing Toxicity and Unpacking DNA: Toward Nonviral Gene Delivery", Angew Chem. Int. Ed., 2013, 52, 9182-9186. Yin, Q.; Yap, F.Y.; Yin, L.; Ma, L.; Zhou, Q.; Dobrucki, L.W.; Fan, T.M.; Gaba, R.C.; Cheng, J. "Poly(iohexol) Nanoparticles As Constrast Agents for In Vivo X-ray Computed Tomography Imaging", J. Am. Chem. Soc., 2013, 135, 13620-13623. Wang, J.; Xia, H.; Zhang, Y.; Lu, H.; Kamat, R.; Dobrynin, A.; Cheng, J.; Lin, Y. "NucleationControlled Polymerization of Nanoparticles into Supramolecular Structures", J. Am. Chem. Soc., 2103, 135, 11417-11420. Tang, H.; Yin, L.; Kim, K.; Cheng, J. "Helical Poly(arginine) Mimics with Superior CellPenetrating and Molecular Transporting Properties", Chemical Science, 2013, 4, 3839 – 3844. Yin, L.; Song, Z.; Kim, KH; Zheng, N.; Gabrielson, NP; Cheng, J. "Non-Viral Gene Delivery Based on Supramolecular Self-Assembled Nanocomplexes via Membrane Penetration and Mannose Targeting", Advanced Materials, 2013, 25, 3063-3070. Uckun. F.M.; Qazi, S.; Cely, I.; Sahin, K.; Shahidzadeh, A.; Tuzcu, M.; Ilhan, N.; Ozercan, I.; Song, Z.; Rodriguez. A.; Gaynon, P.; Termuhlen, A.; Cheng, J.; Yiv, S., Blood, 2013, 121, 4348-4354. Yin, L.; Song, Z.; Kim, K.; Zheng, N.; Tang, H.; Lu, H.; Gabrielson, N.; Cheng, J. “Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery", Biomaterials, 2013, 34, 2340-2349. Song, Z.; Zhang, R.; Lu, H.; Gabrielson, NP; Yin, L.; Ponnusamy, E.; Cheng, J. "Synthesis and Biomedical Applications of Polyamino Acids", Materials Matters, 2013, 8, 78-84. Wang, H.; Tang, L.; Tu, C.; Song, Z.; Yin, Q.; Yin, L.; Zhang, Z.; Cheng, J. "Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly", Biomacromolecules, 2013, 14, 3706-3712. 5

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Zhang, Y.; Yin, Q.; Lu, H.; Xia, H.; Lin, Y.; Cheng, J. "PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation", ACS Macro Letter, 2013, 2, 809-813. Xing, H.; Tang, L.; Yang, X.; Hwang, K.; Wang, W.; Yin, Q.; Wong, N.Y.; Dobrucki, L.W.; Yasui, N.; Katzenellenbogen, J.A., Helferich, W.G., Cheng, J.; Lu, Y. "Selective elivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo", Journal of Materials Chemistry B, 2013, 1, 5288-5297. Tang, L.; Cheng, J. "Nonporous Silica Nanoparticles for Nanomedicine Application", Nano Today, 2013, 8, 290-312. Yen, J.; Zhang, Y.; Gabrielson, N.P.; Yin, L.; Guan, L.; Chaudhury, I.; Lu, L.; Wang, F.; Cheng, J. "Cationic, helical polypeptide-based gene delivery for IMR-90 fibroblasts and human embryonic stem cell", Biomaterials Science, 2013, 1, 719 - 727. Yin, Q.; Tong, R.; Xu, Y.; Dobrucki, L.W.; Fan, T.M.; Cheng, J. "Drug-Initiated Ring-Opening Polymerization of O-Carboxyanhydrides for the Preparation of Anticancer Drug-Poly(OCarboxyanhydride) Nanoconjugates" Biomacromolecules, 2013, 14, 920-929. Cameron JA; Milner DJ; Lee JS; Cheng J; NX Fang; Jasiuk IM. "Employing the biology of successful fracture repair to heal critical size bone defects" Current Topics in Microbiology and Immunology, 2013, 367, 113-132. Zhang, R.; Lu, H.; Gabrielson, N.; Yin, L.; Cheng, J. "Cationic α-Helical Polypeptide Template for Nonviral GeneDelivery", SurFACTS in Biomaterials, 2013,18, 2. Mirshafiee, V.; Mahmoudi, M.; Lou, K.; Cheng, J.; Kraft, ML." Protein Corona Significantly Reduces Active-Targeting Yield", Chemical Communications, 2013, 49, 2557-2559. Tang L, Gabrielson NP, Uckun F.M., Fan TM, Cheng J. "Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates", Molecular Pharmaceuticals. 2013, 10, 883-892. Tong, R.; Tang, L.; Gabrielson, N.P.; Yin, Q.; Cheng, J. "Polymer-Drug Nanoconjugates", book chapter in Nanoparticulate Drug Delivery Systems: Strategies, Technologies, and Applications", Ed. Y. Yeo, Wiley, April 2013. Zhang, Z.; Yin, L.; Zhang, Y.; Xu, Y.; Tong, R.; Zhou, Q.; Ren, J.; Cheng, J. "Redox-Responsive, Core Cross-Linked Polyester Micelles", ACS Macro Lett., 2013, 2, 40-44. Zhang, Y.; Ma, L.; Deng, X.; Cheng, J. "Trigger-Responsive Chain-Shattering Polymers", Polymer Chemistry, 2013, 4, 224-228.

2012 66.

Tang, L.; Yang, X.; Dobrucki, L.W.; Chaudhury, I.; Yin, Q.; Yao, C.; Lezmi, S.; Helferich, WG Fan, TM; Cheng, J. "Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugate for targeted dual-modal imaging of lymph nodes with metastatic tumors", Angew Chem. Int. Ed., 2012, 124, 12893 -12898. 65. Gabrielson, N.; Lu, H.; Yin, L.; Li, D.; Wang, F.; Cheng, J.; "Reactive and Bioactive Cationic gHelical Polypeptide Template for Non-Viral Gene Delivery", Angew. Chem. Int. Ed., 2012, 51, 1143-1147. 64. Tong, R.; Cheng, J.; "Zinc complex mediated regioselective O-acylation of therapeutic agents", Chemical Science, 2012, 3, 2234-2239. 63. Gabrielson, N. P.; Lu, H.; Kim, KH, Cheng, J. "A Cell-Penetrating Helical Polymer for siRNA Delivery to Mammalian Cells", Molecular Therapy, 2012, 20, 1599-1609.

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Tong, R.; Gabrielson, N. P; Fan, TM.; Cheng, J. "Polymeric Nanomedicine Based on Poly(lactic acid) and Poly(lactic-co-glycolic acid)", Current Opinion in Solid State & Materials Science, 2012, 16, 323-332. Zhang, Z.; Yin, L.; Xu, Y.; Ren, J.; Cheng, J. "Facile Functionalization of Polyesters through Thiolyne Chemistry for the Design of Degradable, Cell‒Penetrating and Gene Delivery Dual‒Functional Agents", Biomacromolecules, 2012, 13, 3456-62. Tang, H.; Yin, L.; Lu, H.; Cheng, J. "Water-Soluble Poly(L-serine)s with Elongated and Charged Side-Chains: Synthesis, Conformations and Cell-Penetrating Properties", Biomacromolecules, 2012, 13, 2609-2615. Tong, R.; Tang, L.; Cheng, J. "Development and Application of Anticancer Nanomedicine", Nanostructure Science and Technology in "Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting and Delivery", Ed. by Svenson, S and Prudhomme, RK., 2012. Cely, I.; Yiv, S.;Yin, Q.; Shahidzadeh, A.; Tang, L.; Cheng, J.; Uckun, F.M. "Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles", J. Anal. Oncology, 2012, 1, 1-9. Li, L.; Yin, Q.; Cheng, J., Lu, Y. "Polyvalent Mesoporous Silica Nanoparticle-Aptamer Bioconjugates Target Breast Cancer Cells", Advanced Healthcare Materials, 2012, 1, 567-572. Tang, L.; Azzi, A.; Kwon, M.; Mounayar, M.; Tong, R.; Yin, Q.; Moore, R.; Skartsis, R.; Fan, T. M.; Abdi, R.; Cheng, J. "Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A", Journal of Transplantation, 2012, 2012: 896141. Tang, L.; Fan, TM.; Borst, LB; Cheng, J. "Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates", ACS Nano., 2012, 6, 3954-3966. Lu, Y.; Yin, L.; Zhang, Y.; Xu, Y.; Cheng, J. "Synthesis of water-soluble poly(α-hydroxy acids) from living ring-opening polymerization of O-benzyl-L-serine carboxy-anhydrides", ACS Macro Letters, 2012, 1, 441-444. Tong, R.; Cheng, J. "Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates", Macromolecules, 2012, 45, 2225-2232. Chen, K.; Tang, L.; Garcia, MA; Wang, H.; Lu, H.; Lin,, WY; Hou, S.; Yin., Q.; Shen, CKF.; Cheng, J.; Tseng, HR. "The therapeutic efficacy of camptothecin-encapsulated supramolecular nanoparticles", Biomaterials, 2012, 33, 1162-1169.

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Lu, H.; Wang, J.; Bai, Y.; Lang, J. Liu, S. Lin, Y.; Cheng, J. "Ionic Polypeptides with Unusual Helical Stability", Nature Communications, 2011, 2, 206. Mishra, A.; Lai, GH; Schmidt, NW; Sun, VZ; Rodriguez, AR, Tong, R.; Tang, L.; Cheng, J.; Deming, TJ; Kamei, DT; Wong, GCL. "Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions", PNAS, 2011, 108, 16883-16888. Wang, J.; Lu, H.; Kamat, R.; Pingali, S. V.; Urban, V. S.; Cheng, J.; Lin, Y. "Supramolecular Polymerization from Polypeptide-Grafted Comb Polymers", J. Am. Chem. Soc.,, 2011, 133, 12906-12909. Tong, R., Tang, L., Yin, Q., Cheng, J. "Drug-polyester conjugated nanoparticles for cancer drug delivery", IEEE. Eng Med Biol Soc. 2011, 3, 8337-8339. Wang, J.; Lu, H.; Ren, Y.; Zhang, Y.; Morton, M.; Cheng, J.; Lin, Y. "Interrupted Helical Structure of Grafted Polypeptides in Brush-Like Macromolecules", Macromolecules, 2011, 44, 8699-8708. Bai, Y.; Lu, H.; Ponnusamy, E.; Cheng, J. "Synthesis of Hybrid Block Copolymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of NCA", Chem. Commun. 2011, 47, 10830-10832. 7

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Zhang, Y.; Lu, H.; Yao, L.; Cheng, J. "Water-Soluble Polypeptides with Elongated, Charged Side Chains Adopt Ultra-Stable Helical Conformations", Macromolecules, 2011, 44, 6641-6644. 44. Lu, H.; Bai, Y.; Wang, J.; Gabrielson, N.; Wang, F.; Lin, Y.; Cheng, J. "Ring-Opening Polymerization of g-(4-Vinylbenzyl)-L-Glutamate N-Carboxyanhydride for the Synthesis of Functional Polypeptides", Macromolecules, 2011, 44, 6237. 43. Cheng, J.; Deming, TJ, "Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides." Top Curr. Chem. 2012, 310, 1-26. 42. Li, D.; Zhou, J.; Chowdhury, F.; Cheng, J.; Wang, N.; Wang, F. "The role of mechanical factors in fate decisions of stem cells." Regenerative Medicine, 2011, 6, 229-240. 2010 41.

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34. 33.

Chan, J.; Zhang, L. F.; Tong, R.; Ghosh, D.; Gao, W.; Liao, G.; Yuet, K.; Gray, D.; Rhee, J. W.; Cheng, J.; Golomb, G.; Libby, P; Langer, R.; Farokhzad, O. "Spatiotemporal Controlled Delivery of Nanoparticles to Injured Vasculature", PNAS, 2010, 107, 2213-2218. Li, C.; Zhang, Y.; Hu, J..; Cheng, J.; Liu, S. "Reversible Three-State Switching of Multicolor Fluorescence Emission via Multiple Stimuli-Modulated FRET Processes within Thermoresponsive Polymeric Micelles", Angew. Chem. Int. Ed., 2010, 49, 5120-5124. Gabrielson, N.; Xu, Y.; Cheng, J.; "Multiplexed supramolecular self-assembly for non-viral gene delivery", Biomaterials, 2010, 31, 9117-9127. Azzi J, Tang L, Moore R, Tong R, El Haddad N, Akiyoshi T, Mfarrej B, Yang S, Jurewicz M, Ichimura T, Lindeman N, Cheng J, Abdi R. "Polylactide-Cyclosporin A Nanoparticles for Targeted Immunosuppression", FASEB J., 2010, 24, 3927-3938. Yang, X.; Shi, C.; Tong, R.; Qian, W.; Zhau, H. E.; Wang, R.; Zhu, G., Cheng, J. Yang, Y.; Cheng, T.; Henary, M.; Strekowski, L.; Chung, LWK . "Near Infrared Heptamethine Cyanine Dyes: 1. Cancer Imaging", Clinical Cancer Research, 2010, 16, 2833-2844. Tong, R.; Coyle, V.J; Li, T.; Barger, A.M., Fan, TM; Cheng, J. "Polylactide Nanoparticles Containing Stably-Incorporated Cyanine Dyes for In Vitro and In Vivo Imaging Applications", Microscopy Research and Technique, 2010, 73, 901-909. Chaney, E. J.; Tang, L.; Tong, R.; Rezaeipoor, R.; Cheng, J.; Boppart, S. "Lymphatic Biodistribution of Cy5-LA50/PLA-mPEG5k Nanoparticles for Targeting Metastatic Cells", Molecular Imaging, 2010, 9, 153-162. Tong, R.; Cheng, J. "Controlled Synthesis of Camptothecin-Polylactide Conjugates", Bioconjugate Chem., 2010, 21, 111-121. Tong, R.; Yala, L.; Fan, TM.; Cheng, J. "Controlled Formulation of Paclitaxel-Polylactide Conjugate Nanoparticles", Biomaterials, 2010, 31, 3043-3053.

2009 32.

Lu, H.; Wang, J.; Lin, Y.; Cheng, J. "One-Pot Synthesis of Brush-Like Polymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of Amino Acid NCarboxyanhydrides", J. Am. Chem. Soc., 2009, 131, 13582-13583. 31. Cao, Z.; Tong, R.; Xu, W.; Wong, GWL.; Cheng, J.; Lu, Y. "Reversible cell-specific delivery of chemotherapy drugs using aptamer-functionalized liposomes", Angew. Chem. Int. Ed.,, 2009, 48, 6494-6498. 30. Tong, R.; Cheng, J. "Ring-Opening Polymerization Mediated-Controlled Formulation of Polylactide Nanoparticles", J. Am. Chem. Soc., 2009, 131, 4744-4754. 8

29.

Yigit, MV; Mishra, A.; Tong, R.; Cheng, J.; Wong, GCL.; Lu, Y. "Inorganic mercury detection and controlled release of chelating agents from ion-responsive PEG-liposomes", Chem. Biol., 2009, 16, 937-942. 28. Tong, R., Tang, L., Yala, L., Cheng, J. "Controlled formulation of doxorubicin-polylactide nanoconjugates for cancer drug delivery", IEEE. Eng Med Biol Soc. 2009, 1, 2400-2402. 27. Tong, R.; Christian, D.A.; Tang, L.; Cabral, H.; Baker, J.R. Jr.; Kataoka, K.; Discher, D.; Cheng, J. "Nanopolymeric Therapeutics", MRS Bulletin, 2009, 34, 422-431. 2008 26.

Lu, H.; Cheng, J. "Controlled Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides", J. Am. Chem. Soc., 2008, 130, 1256212563. 25. Tong, R.; Cheng, J. "Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles", Angew. Chem. Int. Ed.,, 2008, 47, 4830-4834. 24. Lee, JS.; Cheng, J.; Kim, KY. "Next Generation Nanosolutions for Cancer Treatment and Diagnosis", Cancer and Chemotherapy Review, 2008, 3, 144-151. 23. Teply, BA; Tong, R.; Jeong, SY; Luther,G.; Sherifi, I.; Yim, CH; Khademhosseini, A.; Farokhzad,OC; Langer R.; Cheng J. "Charge-Coupled Polymeric Microparticles and Micromagnets Allow External Modulation of the Bioavailability of Orally Delivered Macromolecules", Biomaterials, 2008, 29, 1216-1223. 2007 Lu, H.; Cheng, J. "Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino AcidNCarboxyanhydrides", J. Am. Chem. Soc., 2007, 129, 14114-14115. 21. Cheng, J.; Teply, B.; Sherifi, I.; Sung, J.; Luther. G.; Gu, F.X.; Levy-Nissenbaum, E.; Langer, R. Farokhzad, OC. "Formulation of Functionalized PLGA-PEG Nanoparticles for In Vivo Targeted Drug Delivery", Biomaterials, 2007, 28, 869-876. 20. Tong, R.; Cheng, J. "Anticancer Polymeric Nanomedicines", Polymer Reviews, 2007, 47, 345-381. 19. Karp J. M., Yeh, J.;, Eng, G. , Fukuda, J.; Blumling, J.; Suh, K. Y.; Cheng, J.; Mahdavi, A.; Jeffrey Borenstein, J.; Langer, R.; Khademhosseini, A. "Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells", Lab Chip, 2007, 7, 786 - 794. 22.

2006 18.

Farokhzad, OC; Cheng J. (co-first author), Teply, B.A.; Sherifi I.; Khademhosseini A.; Langer, R. "In vivo prostate tumor reduction after single administration of docetaxel encapsulated nanoparticle-aptamer bioconjugates", PNAS, 2006, 103, 6315-6320. 17. Cheng, J. Zeidan, R. Mishra, M., Liu, A., Pun, SH., Kulkarni, RP; Jensen, GS, Bellocq, N., and Davis ME;, Structure-Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Non-Viral Gene Delivery. J. Med. Chem., 2006, 49, 6522-6531. 16. Schluep T., Hwang J., Cheng J., Heidel, J.D.; Derek W., Bartlett, DW, Davis M.E. "Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models." Clinical Cancer Research, 2006, 12, 1606-1614. 15. Cheng, J.; Teply, B. Yim, C.; Jeong, SY, Sherifi, I.; Jon, S.; A. Khademhosseini; Farokhzad, OC; Langer, RS. "Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs", Pharmaceutical Research, 2006, 23, 557-564. 9

14.

13.

Fukuda, J.; Khademhosseini A.; Yeh, J.; Eng, G.; Cheng, J., Farokhzad, OC; Langer, RS. "Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components", Biomaterials, 2006, 27, 1479-1486. Schluep, T.; Cheng, J.; Khin KT, Davis, ME "Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor bearing mice", Cancer Chemotherapy and Pharmacology, 2006, 57, 654-662.

Before 2005 12.

Cheng, J.; Yin, CH; Teply, BA.; Ho, D.; Farokhzad, OC; Langer, RS. “Magnetite-PLGA Microparticles for Oral Delivery of Insulin”, Mater. Res. Soc. Symp. Proc., 2005, 873, K581. 11. Cheng, J. and Pun, S. H.; "Nanotechnology in Drug Delivery", In "An Executive's Guide to Nanotechnology", Editor: Lynn Foster, Prentice Hall, 2005. 10. Farokhzad, O.; Khademhosseini, A.; Jon, S.; Hermmann, A.; Cheng, J.; Chin, C.; Kiselyuk, A.; Eng, G.; Langer, R. "Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells" Analytical Chemistry, 2005, 77, 5453-5459. 9. Pun, S. H.; Bellocq, N. C.; Cheng, J.; Grubbs, B. H.; Jensen, G. S.; Davis, M. E.; Tack, F.; Brewster, M.; Janicot, M.; Janssens, B.; Floren, W.; Bakker, A.; "Biodistribution of RNA-cleaving DNA Enzyme (DNAzyme) to Tumor Tissue by Transferrin-Modified, Cyclodextrin-Based Particles", Cancer Biology and Therapy, 2004, 3, 641-650. 8. Cheng, J.; Khin, K. T.; Davis, M. E. "Antitumor Activity of (β-Cyclodextrin PolymerCamptothecin Conjugates", Molecular Pharmaceutics, 2004, 1, 183-193. 7. Cheng, J.; Khin, K. T.; Jensen, G. S.; Liu, A.; Davis, M. E. "Synthesis of Linear, β-CyclodextrinBased Polymers and Their Camptothecin Conjugates", Bioconjugate Chemistry, 2003, 14, 10071017. 6. Cheng, J.; Deming, T. J., "Controlled Polymerization of Beta-lactams Using Metal-Amido Complexes: Synthesis of Block Copoly(β-peptides)", J. Am. Chem. Soc.,, 2001, 123, 9457-9458. 5. Cheng, J.; Deming, T. J. "Synthesis and Conformational Analysis of Optically Active Poly(βpeptides)", Macromolecules, 2001, 34, 5169-5174. 4. Cheng, J.; Ziller, J. W.; Deming, T. J. "Synthesis of Optically Active β-Amino Acid NCarboxyanhydrides". Organic Letters, 2000, 2, 1943-1946. 3. Cheng, J.; Deming, T. J. "Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of α-Benzyl Glutamate-N-Carboxyanhydride". Macromolecules, 1999, 32, 47454747. 2. Smith, G. V.; Cheng, J.; Song, R. "New Enantioselective Heterogeneous Catalysts", Catalysts Letters, 1997, 45, 73-78. 1. Smith, G. V.; Cheng, J.; Song, R. "Enantioselective Hydrogenation of Prochiral C=C Bonds over Nobel Metal Catalysts Supported by β-Cyclodextrin Polymer", Catalysts of Organic Reactions, 1996, 479-484. CONFERENCE PROCEEDINGS 13. Tong, R.; Cheng, J. “Development of polymeric nanoconjugates” PMSE Preprints, 2009, 101, 1009-1010. 12. Lu, H.; Cheng, J. “N-trimethylsilyl amines for controlled ring-opening polymerization of amino acid N-carboxyanhydrides and facile end group functionalization of polypeptides” PMSE Preprints, 2009, 100, 602. 11. Tong, R.; Cheng, J. “Hexamethyldisilazane-mediated controlled polymerization of .alpha.-amino acid N-carboxyanhydrides” Polymer Preprints, 2008, 49, 337. 10

10. 9. 8. 7. 6. 5. 4.

3.

2. 1.

Tong, R.; Cheng, J. “Conjugated polylactide-drug nanoparticles for drug delivery”, 2008, 98, 313 Lu, H.; Cheng, J. “Living ring opening polymerization of amino acid-N-carboxyanhydrides” Polymeric Materials Science and Engineering Preprints, 2007, 97,185. Lu, H.; Cheng, J. “Living ring opening polymerization of amino acid-N-carboxyanhydrides” Polymeric Materials Science and Engineering Preprints, 2007, 97,440. Tong, R.; Cheng, J. “Polylactide-paclitaxel nanoparticles with controlled sizes and toxicities” Polymer Preprints, 2007, 48, 941. Tong, R.; Cheng, J. “Polymeric nanoparticles with controlled sizes for targeted drug delivery.” Polymeric Materials Science and Engineering Preprints, 2007, 96, 333. Cheng J., Yim, C.H., Teply, T.A., Ho, D., Farokhzad, O.C., and Langer, R.S., “Magnetite-PLGA Microparticles for Oral Delivery of Insulin,” Mat. Res. Soc. Symp. Proc., 873E, K5.8.1 (2005). Cheng, J., Khin, K.T., Liu, A., Jensen, G., and Davis, M.E., “Antitumor activity of linearcyclodextrin polymer conjugates of camptothecin,” AIChE Ann. Mtg., Conf. Proc., San Francisco, CA, United States, 95-99 (2003). Cheng, J.; Bellocq, N.; Pun, S. H.; Khin, K. T.; Liu, A.; Jensen, G. S.; Dartt, C. B.; Davis, M. E. “Linear, cyclodextrin-based polymers for the delivery of broad ranging therapeutics.” Polymeric Materials Science and Engineering Preprints, 2003, 89, 52. Cheng, J.; Deming, T. J. “Synthesis and conformational studies of poly(beta-homolysine).” Polymer Preprints, 1999, 41, 973. Cheng, J.; Deming, T. J. “Enantioselective polymerization of γ-benzyl glutamate Ncarboxyanhydride using chiral nickel(0) initiators.” Polymeric Materials Science and Engineering, 1999, 80, 473.

PATENTS (Patents 1-7 have been licensed) 24. Cheng, J.; Tong R. ““Nanoconjugates and Nanoconjugate Formulations”, US Patent Application 13/518,836. 23. Cheng, J.; Cai, K. “Trigger Responsive Drug Conjugate for High Loading Nanoencapsulates”, February 25, 2015, 62/120,821. 22. Cheng, J.; Xiong, M.; Chen, L.; Bao, Y. “Polypeptide for H-Pylori Treatment”, Provisional Appl. 2014. 21. Cheng, J.; Ying, H. "Hydrolysable polymers with dynamic urea bonds", 62/069,384, 10/28/2014. 20. Cheng, J.; Ying, H.; Zhang, Y. "Dynamic urea bonds for polymers", 62/069,385, 10/28/2014. 19. Rogers, JA; Kang, S.; Hwang, S.; Cheng, J.; Zhang, Z.; Ying, H. "Transient Electronic Devices Comprising Inorganic or Hybrid Inorganic and Organic substrates and encapsulates”, No. 61/811,603. 18. Cheng, J.; Ying, H. "Dynamic urea bonds for reversible and self-healing polymers", 61/799,144, 3/14/2013. 17. Cheng, J.; Yin, L. "Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-a siRNA Against Systemic Inflammation" US 61/810,983, 2013. (TF13054) 16. Cheng, J.; Zhang, Y. "Trigger-Responsive, Degradable Polymers" US 61/649,205, US 61/648,715, 2012. (TF11176). 15. Cheng, J.; Lu, H. "Ionic Polypeptides with Unusual Helical Stability" Converted US 61/418,269, WO PCT/US2011/062656, 2011. (TF10060). 14. Cheng, J.; Gabrielson. "Supramolecular Assembly for Non-Viral Gene Delivery" US 61/371,618 2010, WO PCT/US2011/046791, 2011 (TF10042). 13. Cheng, J.; Tong, R. "Aptamer-Coated Paclitaxel-Polyactide Nanoconjugates: Formulation & Cancer Targeting" US 61/289,893, WO PCT/US2010/062030 2010 (TF09151). 11

12.

Cheng, J.; Tang, L. "Preparation of Degradable Silica-Drug Conjugated Nanoparticle with Monodisperse Particle Sizes" US 61/418,230 2010, WO PCT/US2011/062548, 2011 (TF09149). 11. Cheng, J.; Tong, R. "Particulate Drug Delivery" PRO 60/892,834, 2007; US 12/041,529 2008; WO PCT/US2008/055590 2008 (TF06188). 10. Chung, LWK; Yang, X.; Cheng, J.; Tong, R. "Small molecule mediated cancer targeting and therapy" provisional application, 2008. 9. Cheng, J.; Lu, H. "Controlled Ring-Opening Polymerization of NCA Using Organosilicon Reagents", provisional application, 2008. 8. Cheng, J; Tong, R. "Particulate Drug Delivery", PCT International Application, 2008. 7. Farokhzad, O.; Cheng, J.; Teply, B.; Langer, R. S. "System for targeted delivery of therapeutics agents", PCT international application, 2007, licensed. 6. Jon, S.; Farokhzad, O. C.; Langer, R. S.; Cheng, J. "Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals", PCT. International Application, 2006, licensed. 5. Bellocq, N. C.; Cheng, J; Pun, S. H.; Davis, M.E. "Carbohydrate-Modified Polymers, Compositions and Uses Related Thereto", PCT. International Application, 2004, licensed. 4. Cheng, J; Davis, M. E.; Khin, K. T. "Cyclodextrin-Based Polymers for Therapeutics Delivery", PCT. International Application, 7,270,808, issued in 2007, licensed. 3. Pun, S. H.; Gonzalez, H.; Davis, M. E.; Bellocq, N. C.; Cheng, J. "Complexing agents for compositions containing inclusion complexes", US 716, 6302, issued in 2007, licensed. 2. Pun, S. H.; Gonzalez, H.; Davis, M. E.; Bellocq, N. C.; Cheng, J. "Compositions containing inclusion complexes", PCT. International Application, 701,8609, issued, licensed. 1. Deming. T. J.; Cheng, J., "Transition Metal Initiators for Controlled Poly(β-peptide) Synthesis from Beta-Lactam Monomers ", 681,8732, issued in 2004. Licensed. TECHNOLOGY DEVELOPED OR TRANSFERRED 1. PLGA nanoparticle-aptamer targeting and delivery technology, licensed to BIND Therapeutics, Inc. currently in Phase II clinical trial. 2. IT-101 drug delivery technology developed at Insert Therapeutics was licensed to Cerulean Pharma, currently in Phase II clinical trial. RESEARCH IMPACT, FEATURED ARTICLE AND NEWS REPORTS 9. Illinois News Bureau, "High-efficiency motor neurons differentiation from human pluripotent stem cells and the function of Islet-1", Nature Communications, 2014, has been featured in the Illinois News Bureau. 8. "Dynamic urea bond for the design of reversible and self-healing polymers", Nature Communications, 2014, 5: 3218, has been featured in the Illinois News Bureau. See "Off-the-shelf materials lead to self-healing polymers" by Liz Ahlberg, Illinois News Bureau. His research has also been featured on many online news outlets such as NSF Science360, geek.com, Phys.org, and PaintSquare. 7. "Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release capability", Angew. Chem. Int. Ed, 2013, is featured in C&EN news (May 13, 2013). 6. Illinois News Bureau, “Simpler way of making proteins could lead to new nanomedicine agents” by Liz Ahlberg (Feb., 2011) http://www.sciencedaily.com/releases/2011/02/110223092402.htm. Also reported by the E! Science News, Science Codex, e-EurekAlert, etc 5. Chemical and Engineering News, “One-Pot Route To Brushy, Peptide-Bearing Polymers”. (Sept. 14, 2009) 12

4.

3.

2. 1.

Illinois News Bureau, “New cancer drug delivery system is effective and reversible” by Diana Yates, (Aug. 6, 2009). Also reported by the Medical News, Lab Spaces, the Royal Society of Chemistry (http://www.rsc.org/chemistryworld/News/2009/July/28070901.asp), Science Centric, Science Codex, redOrbit, Azo Nanotechnology, e! Science News, PhysOrg, Huliq News, WebWire, Bio-Medicine, Private Healthcare UK, Genetic Engineering and Biotechnology News, and Association of Cancer Online Resources, etc. National Cancer Institute Alliance for Nanotechnology in Cancer “Tackling metastasis through team science: Cancer biologists lead the charge synergizing their discoveries behind common nanotechnology platforms” (September, 2008). National Cancer Institute Alliance for Nanotechnology in Cancer, “Anticancer Drug Triggers Nanoparticle Formation, Improves Stability In Vivo” (Aug. 6, 2008). Forbes Magazine, “Top Five Nanotechnology Breakthroughs of 2006”, by Josh Wolfe (Dec. 27, 2006)

INVITED PRESENTATIONS AND SEMINARS 120. University of South Carolina, April 5, 2016 119. Tufts University, April 4, 2016 118. Fusion Conferences, Drug Delivery Symposium, Sept. 28-Oct. 1, Arizona, 2015 117. Symposium of Cancer-Targeted Delivery of Therapeutics and Diagnostics, PacifiChem 2015, Dec. 2015 116. IUPAC 11th International Conference on Novel Materials and their Synthesis (NMS-XI), Oct. 1116, 2015, Qinhuangdao, China 115. Cancer Nanotechnology Gordon Research Conference, Design of Anticancer Nanomedicine via Controlled Chemistry, West Dover, VT, June 28-July 3, 2015 114. Department of Chemical Engineering, Zhejiang University 113. Department of Pharmaceutical Science, FuDan University, June 2015 112. Changchun Institute of Applied Chemistry, Chinese Academy of Science, June 2015 111. Department of Chemistry, Beijing University, June 2015 110. Symposium of Polymeric Biomaterials, University of Science and Technology of China, June 2015 109. FUNSOM, Soochow University, June 2015 108. Polymer Advanced Technologies, June 25-28, Hangzhou, China 107. Keynote Speech, China Conference on Nanomedicine and Nanobiotechnology (ChinaNanomedicine 2015), April 6-9, 2015, Hangzhou, China 106. Department of Chemical Engineering, University at Buffalo, The State University of New York, April, 2015 105. 249th ACS National Meeting, Denver, CO, April, 2015 104. First International Symposium on Translational Nanomedicine, Guangzhou, NanoMed Guangzhou, China, Jan. 8-10, 2015 103. The Functional Nano & Soft Materials Laboratory, Suzhou University, China, Sept. 17. 2014 102. The 3rd Symposium on Innovative Polymers for Controlled Delivery (SIPCD 2014). Suzhou, China, Sept. 16-19, 2014 101. The 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Chicago, IL August 26- 30, 2014 100. The Second International Symposium on Polymer Ecomaterials (PEM 2014), Kunming, China, August 22- 26, 2014 99. Biomacromolecules/Macromolecules Young Investigator Award Symposium, 248th ACS National Meeting, San Francisco, California, August 10-14, 2014 98. Bioinspired Materials, Gordon Research Conference, Newry, ME, June 22-27, 2014. 13

97. 10th International Symposium Polymer Therapeutics. 19-21 May 2014. Valencia (Spain) 96. Beckman Director’s Seminar, Beckman Institute, University of Illinois, Urbana, March, 2014 95. Chemical Engineering, Akron University, Akron, OH, Feb. 2014 94. Vanderbilt Institute of Nanoscale Science and Engineering (VINSE), Vanderbilt Univ., Jan. 2014 93. MRS Meeting, Boston, MA, Dec. 2013 92. Indiana University, Bloomington, IN, Oct. 2013 91. Stevens Institute of Technology, Hoboken, NJ, Oct. 2013 90. Department of Chemistry, University of South Carolina, October, 2013 89. Polymer Science, University of Connecticut, Sept. 2013 88. NSF workshop on BioMEMS and Tissue Engineering, Boston, MA, July, 2013 87. International Advanced Drug Delivery Symposium 2013 (IADDS 2013), Taiwan, May 2013 86. American Society of Gene & Cell Therapy 16th Annual Meeting, Salt Lake City, UT, May 15 - 18, 2013 85. ACS Meeting, Symposium "Bottom-up design of the next generation of biomaterials", April 7-11, 2013 84. iCeMS International Symposium, "Cell-Material Integration and Biomaterials Science", Kyoto University, Japan, March, 2013 83. MRS Meeting, Dec. 2012, Boston, MA 82. Department of Chemical Engineering, University of Iowa, 2012, Iowa City, IA 81. International Symposium of Materials on Regenerative Medicine, Aug 2012, Taipei, Taiwan 80. School of Pharmacy, Huazhong Science and Technology University, June 2012, Wuhan, China 79. Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Science, June 2012, Beijing, China 78. Institute of Chemistry, Chinese Academy of Science, June, 2012, Beijing, China 77. International Nanomedicine Symposium, Tsinghua University, June, 2012, Beijing, China 76. The 9th World Biomaterials Congress, June, 2012, Chengdu, China. 75. CNST Annual Symposium, UIUC, May, 2012 74. College of Medicine Research Symposium, Translational Cancer Research: Improving Diagnosis and Outcomes, UIUC, April, 2012 73. Department of Polymer Science and Engineering, University of Massachusetts at Amherst, Feb. 2012 72. College of Medicine Research Symposium, Translational Cancer Research: Improving Diagnosis and Outcomes, UIUC, April, 2012 71. Department of Chemistry, Colorado State University, March, 2012 70. Department of Polymer Science and Engineering, University of Massachusetts at Amherst, Feb. 2012 69. Department of Chemistry, Louisiana State University, Oct, 2011 68. Department of Chemistry and Chemical Engineering, Colorado State University, Fort Collins, CO, Sept.23, 2011 67. Polymer Science National Meeting, Dalian, China, Sept. 2011 66. PMSE, American Chemical Society National Meeting, Denver, CO, August, 2011 65. BioNanotechnology Summer Institute, UIUC, July 25, 2011 64 Recent Advances in Nanotechnology for Cancer Therapy symposium, University of Illinois at Chicago College of Pharmacy, Chicago, IL August 12, 2011. 63. NIH, NIEHS, North Carolina, July, 2011 62. Development of Anticancer Nanomedicine, Distinguished Speaker Series, Agricultural, Consumer and Environmental Sciences, UIUC, June 23, 2011 61. CNST Annual Nanotechnology Workshop and nPEAP workshop, May 12-13, 2011 60. M-CNTC/IGERT/CCM Nanomedicine Seminar, UIUC, March 29, 2011 59. Gordon Research Conference, Ventura, CA, January 9-14, 2011 14

58. Department of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai, China, Dec, 2010 57.Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang Province, China, Dec, 2010 56. Materials Research Society National Meeting, Boston, MA, Dec., 2010 55. Cerulean Pharmaceutical Inc., Boston, MA, Nov. 2010 54. Symposium of Nanotechnology in Medicine and Biotechnology, Institution of Mechanical Engineers, London, United Kingdom, Oct., 2010 53. Department of Pharmacy, Purdue University, September, 2010 52. Children’s Hospital, Harvard Medical School, Boston, Massachusetts, August, 2010 51. POLY, American Chemical Society National Meeting, Boston, Massachusetts, August, 2010 50. PMSE, American Chemical Society National Meeting, Boston, Massachusetts, August, 2010 49. UIC Cancer Center, University of Illinois, Chicago, IL, June, 2010 48. Simon Cancer Center, Indiana University, June, 2010 47. Department of Polymer Science and Engineering, Nanjing University, Nanjing, China, June, 2010 46. Department of Chemistry, Shanghai Jian Tong University, Shanghai, China, May, 2010 45. Plenary Presentation, The 5th PharmSci@Asia2010, Shanghai, China, May, 2010 44. Shanghai Institute of Organic Chemistry, Shanghai, China, May, 2010 43. Particles 2010: Medical/Biochemical Diagnostic, Pharmaceutical, and Drug Delivery Applications of Particle Technology, Lake Buena Vista, Florida, May, 2010 42. Symposium of Implementing and Effectively Performing Phase 0 Trials in Drug Discovery, NextLevel Pharma, Munich, Germany, May, 2010 41. Department of Biomedical Engineering, Cornell University, Ithaca, NY, April, 2010 40. Department of Pharmaceutical Science, University of Illinois, Chicago, IL, April, 2010 39. Department of Bioengineering, University of Illinois at Urbana−Champaign, Urbana, IL, March, 2010 38. Translational Biomedical Research Seminars, University of Illinois at Urbana−Champaign, Urbana, IL, Feb., 2010. 37. Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Dec., 2009 36. Department of Chemistry, University of Memphis, TN, Nov, 2009 35. Department of Chemical Engineering, University of Washington, Seattle, WA, Oct., 2009 34. Department of Urology, School of Medicine, Northwestern University, Evanston, IL, Oct., 2009 33. Department of Chemistry, University of California, Irvine, CA, Oct., 2009 32. Materials Research Laboratory, University of California, Santa Barbara, CA, Oct., 2009 31. Department of Nanoengineering, University of California, San Diego, CA, Oct., 2009 30. Department of Bioengineering, University of California, Los Angeles, CA, Oct, 2009 29. Department of Polymer Science and Engineering, Nanjing University, Nanjing, China, June, 2009 28. Department of Polymer Science and Engineering, University of Science and Technology of China (USTC), Hefei, China, June, 2009 27. Department of Polymer Science and Engineering, Nankai University, Tianjin, China, June, 2009 26. Institute of Chemistry, The Chinese Academy of Sciences, Beijing, China, June, 2009 25. Department of Polymer Science and Engineering, Qinghua University, Beijing, China, June, 2009 24. Department of Chemistry, Beijing University, Beijing, China, June, 2009 23. Department of Materials Science and Engineering, Tongji University, Shanghai, China, June, 2009 22. Department of Polymer Science and Engineering, Fudan University, Shanghai, China, June, 2009 21. Department of Materials Science and Engineering, The Johns Hopkins University, Baltimore, MD, Feb., 2009 20. Chemical Engineering, Robert Langer Laboratory, Massachusetts Institute of Technology, Dec., 2008 15

19. Materials Research Society National Meeting, Boston, MA, Dec., 2008 18. Nanotechnology in Medicine and Biotechnology Symposium, Institution of Mechanical Engineers, London, United Kingdom, Sept., 2008 17. Third Annual NCI Nanotechnology Alliance Investigators Meeting, Chicago, IL, Sept, 2008 16. Department of Materials Science and Engineering, Imperial College London, London, United Kingdom, August, 2008 15. Schering Plough, Summit, NJ, March, 2008 14. The 234th American Chemical Society National Meeting, Boston, MA, July, 2007 13. Center for Nanoscale Science and Technology Nanomedicine Symposium, University of Illinois at Urbana−Champaign, Urbana, IL, May, 2007 12. Department of Veterinary Medicine, University of Illinois at Urbana−Champaign, Urbana, IL, April, 2007 11. Mills Breast Cancer Institute, Carle Foundation Hospital, Urbana, IL, March, 2007 10. Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, June, 2006 9. Materials Science and Engineering, University of Delaware, Newark, DE, March, 2005 8. Materials Science and Engineering, North Carolina State University, Raleigh, NC, March, 2005 7. Polymer Engineering, Akron University, Akron, OH, Feb., 2005 6. Department of Chemistry, Polytechnic University of New York, Brooklyn, NY, Nov., 2004 5. Department of Chemistry, Ohio University, Athens, OH, May, 2004 4. Materials Research Laboratory, University of California, Santa Barbara, CA, Oct., 2003 3. The 226th American Chemical Society National Meeting, New York, NY, August, 2003 2. Alliance Pharmaceutical Corp., San Diego, CA, Dec., 2000 1. NASA Langley Research Center and ICASE, Hampton, VA, Nov. 1999 CONTRIBUTED PRESENTATIONS 33. PMSE, American Chemical Society National Meeting, San Francisco, CA, March, 2010 32. The 10th US-Japan Symposium on Drug Delivery Systems, Maui, HI, Dec., 2009 31. The 235th ACS National Meeting, New Orleans, LA, April, 2008 30. The 235th ACS National Meeting, New Orleans, LA, April, 2008 29. The 9th US-Japan Symposium on Drug Delivery Systems, Maui, HI, Dec., 2007 28. NIH NCI symposium, Washington University, St. Louis, MO, Oct., 2007 27. The Second NIH NCI-CCNE Workshop, University of North Carolina, Oct., 2007 26. The fifth International Nanomedicine and Drug Delivery Symposium, Boston, MA, Nov., 2007 25. Prostate Cancer Foundation 14th Annual Scientific Retreat, Lake Tahoe, NE, Oct., 2007 24. The 234th American Chemical Society National Meeting, Boston, MA, August, 2007. 23. Gordon Research Conference-Polymers, Mount Holyoke College, South Hadley, MA, June, 2007 22. ACS National Meeting, Chicago, IL, March, 2007 21. The Eighth Annual Meeting of the American Society of Gene Therapy, Baltimore, MD, June, 2006. 20. The 231st ACS National Meeting, Atlanta, GA, March, 2006 19. MRS National Meeting, San Francisco, CA, March, 2006 18. Federation of European Cancer Societies, Paris, France, Oct. 2005. 17. The 8th US-Japan Symposium on Drug Delivery Systems, Maui, Hawaii, December, 2005 16. MIT Center for Cancer Research Retreat , Water Valley , NH, Oct. 2005. 15. Materials Research Society Fall Meeting, Boston, MA,, Nov. 2005. 14. The third International Nanomedicine and Drug Delivery Symposium, Baltimore, MD, Sept, 2005. 13. AACR Meeting, Anaheim, CA, April, 2005. 12. Materials Research Society Spring National Meeting, San Francisco, CA, March, 2005. 16

11. DuPont-MIT Alliance Symposium, Massachusetts Institute of Technology, Cambridge, MA, Oct., 2004. 10. The American Institute of Chemical Engineering National Meeting, San Francisco, CA, Nov., 2003 9. The Controlled Release Society 30th Annual Meeting and Exposition, Glasgow, Scotland, July, 2003. 8. The Winter Symposium and 11th International Symposium on Recent Advances in Drug Delivery Systems, Salt lake City, Utah, March, 2003. 7. The American Institute of Chemical Engineering National Meeting, Indianapolis, IN, 2002. 6. The Second International Symposium on Tumor Targeted Drug Delivery Systems, NIH, Rockville, MD, September, 2002. 5. The Fifth Annual Meeting of the American Society of Gene Therapy, Boston, MA, June, 2002. 4. Materials Research Outreach Symposium, University of California, Santa Barbara, Jan., 2001. 2. The 222nd American Chemical Society National Meeting, Chicago, IL. Aug., 2001. 2. The 219th American Chemical Society National Meeting, San Francisco, CA, March, 2000. 1. The 217th American Chemical Society National Meeting, Anaheim, CA, August, 1999. RESEARCH GRANTS ($9.3M to the Cheng lab, 08/2005-04/2015) 1R21EB013379-01 (PI: Chen) $135,000 NIH/NIDDK Antimicrobial activity of pH-activated polypeptides toward H. pylori Major goal: To develop antimicrobial polypeptides against H. pylori disease Role: co-PI

05/01/15-04/30/17

National Science Foundation-MPS-Chemistry (Role: PI(Single PI )) $220k Title: Hindered Urea Bond Based Dynamic Chemistry and Polymer Synthesis

09/16/15-09/15/17

DOE-BES (PI: W. Wilson, $759,000; $90k allocated to Cheng) Title: Fluidic-Directed Assembly of Functional Materials using Tailored Flows

06/2014-05/2017

Roy J. Carver Charitable Trust, $298,636 (Role: PI (Single PI )) Title: Cancer targeting analysis via live animal imaging system Equipment award for the purchase of a live animal imaging system

11/2013-10/2015

National Science Foundation-MPS-DMR (Role: PI (Single PI )) $390k Title: Responsive Drug-Polymer Conjugate

09/2013-08/2016

National Science Foundation-MPS-Chemistry (Role: PI(Single PI )) $390k 09/2013-/08/2016 Title: Poly(alpha-hydroxy acids) via Ring-Opening Polymerization of O-Carboxyanhydrides In3 Seed grant (PI: Y Lu, total $200,000; $44 k allocated to Cheng) Title: Liposome-aptamer for targeted cancer therapy

09/2012-08/2013

CABPN grant-Growmark (Role: co-PI, PI:Cunningham) ($32k allocated to Cheng)09/2012-08/2013 Title: Silica nanoparticle for herbicide delivery CABPN grant (Role: co-PI, PI:Cunningham) ($50k allocated to Cheng) Title: Helical polypeptide for non-viral gene delivery 17

09/2011-08/2013

National Science Foundation-MPS-Chemistry (Role: PI(Single PI )) $270k 08/2012-/07/2014 Title: Synthesis and Studies of Water-Soluble, α-Helical Polypeptides with Charged Side Chains Dow Chemicals (PI: Jeffrey Moore) $3.5M ($750k allocated to Cheng) Novel Solutions for Targeted and Triggered Release of Actives

09/2011-08/2016

Dow Chemicals (PI: Jeffrey Moore) $3.5M ($750k allocated to Cheng) New Materials for Encapsulants

09/2011-08/2016

Research Seed Grant (PI: Neelu Puri) $45k ($15k to Cheng) 07/2011-06/2013 UIC Cancer Center Mechanism of Action and Role of Nano-Assembled Structures as a Drug Delivery System for Novel Therapeutic Agent T-Oligo Research Seed Grant (PI: Ron Gaba; Role: co-PI) $37,650 ($15k to Cheng) 07/2011-06/2013 Radiological Society of North American Polymeric Iohexol Nanoconjugates for Targeted Transcatheter Drug Delivery: Quantitative CT Analysis of Spatial Distribution in a Rabbit VX2 Liver Tumor Model 1R21EB013379-01 (PI: Cheng) $224k (Year 1), $190k (Year 2) NIH/NCI Development of Helical Polypeptides for Non-Viral Gene Delivery Systems

07/2011-06/2013

OTM Concept Award (PI: Cheng) $75k 2011-2013 Development of Polymeric Nanoconjugates for Cancer Targeting and Treatment 1 R21 CA152627-01 (PI: Cheng) $418k 01/2011-12/2012 NIH/NCI Camptothecin-Contining Nanoparticles: Control Over Particle Size, Biodistribution and Cancer Targeting NIH Director’s New Innovator Award (PI: Cheng) DP2 OD007246-01 $2,375k to Cheng 09/2010-06/2015 Title of Project: Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates NIH-Supplementary (Role co-PI; PI: F. Wang) $50k to Cheng 2010-2012 Multi-functional Aptamer-Lipid Theranostic Anticancer Agents: a Novel Approach in Nanomedicine Cell-Based High-Throughput Assays for Fate Decisions of Human Embryonic Stem Cell Beckman Institute (Role co-PI; PI: Y. Lu) $50k to Cheng 2010-2012 Multi-functional Aptamer-Lipid Theranostic Anticancer Agents: a Novel Approach in Nanomedicine NIH-SCCNE (PI: Cheng) $100k to Cheng Development of Silica Nanoparticle for Anticancer Drug Delivery

2009-2010

Morris Animal Foundation (Role: co-PI; PI: T. Fan)

2009-2011

18

$40k to Cheng

Phase I trial-Development of bone-seeking nanoparticles encapsulating doxorubicin for canine appendicular osteosarcoma Cedar Sinai Cancer Center (Role: PI) $100k to Cheng IR783-Dye-Docetaxel Conjugate for Targeted Cancer Therapy

2009-2010

National Institute of Health-NIBIB R21 (Role: PI) $418k Ring-Opening Polymerization of OCA for the Synthesis of PHA

2009-2011

National Institute of Health-NCI R21 (Role: PI) $418k Aptamer-Polylactide Nanoparticles for Targeted Prostate Cancer Therapy

2009-2011

National Science Foundation-MPS-Chemistry (Role: PI) Controlled Polymerization of Amino Acid-N-Carboxyanhydride

2008-2011

$484k

National Science Foundation-DMR Career Award (Role: PI) $625k Development of Conjugated Polymer-Drug Nanoparticulate Delivery Vehicles

2008-2013

NIH-SCCNE (Role: PI) $80k 2007-2008 Red-Blood-Cell-Hitchhiking Nanoparticles for Controlled Drug Delivery and Cancer Therapy American Chemical Society-Petroleum Research Fund (Role: PI) $50k Beta-Peptide Nucleic Acid-Based Self-Assembly via Nucleobase Pairing

2006-2008

Prostate Cancer Foundation (Role: PI) $100k (40k to Cheng) 2006-2007 Aptazyme-Actuated Invertible Liposomes for Targeted Prostate Cancer Therapy NIH-SCCNE (Role: PI) $80k Dendritic polymer nanoparticle for targeted breast cancer therapy

2006-2007

Research Board, ILLINOIS (Role: PI) $14k Crossing the Blood-Brain Barrier with Fluorinated Nanoparticles

2006-2007

JOURNALS REFEREE Nature Chemistry Nature Nanotechnology Nature Materials Journal of American Chemical Society PNAS Angewandte Chemie International Edition ACS Nano Advanced Materials Advanced Healthcare Materials Cancer Research Materials Today Nano Today MRS Bulletin Nano Letters

Molecular Pharmaceutics Pharmaceutical Research Bioconjugate Chemistry Biomacromolecule Journal of Control Release Macromolecules ACS Macro Letters Journals of Biomedical Materials Research Current Pharmacy Review Journal of Drug Targeting European Journal of Medicinal Chemistry European Journal of Pharma. Science Journal of Biomedical Optics Transaction on Nanotechnology 19

International Journal of Nanomedicine Nanomedicine Acta Biomaterialia

Biomaterials Molecular Therapeutic Biomaterials Science

Current postdoctoral associates and graduate students (2 postdoc, 8 graduate students) Yang Liu (Postdoctoral Associate) Menghua Xiong (Postdoctoral Associate) Hanze Ying (Ph.D. graduate student) Ziyuan Song (Ph.D. graduate student) Kaimin Cai (Ph.D. graduate student) Hua Wang (Ph.D. graduate student) Ryan Baumgartner (Ph.D. graduate student) Ruibo Wang (Ph.D. graduate student) Zhiyuan Han (Ph.D. graduate student) Yingfeng Yang (Ph.D. graduate student) Xi He (Ph.D. graduate student) Current technician and lab manager Zhiyu Wang Former postdoctoral associates Name Current Position Xueyun Gao Professor, Ins. of High Energy Physics, Chinese Academy of Science Nathan Gabrielson Lecturer, UIUC Yunxiang Xu Associate Professor, Sichuan University Jungsong Lee Postdoctor, Yale University Haoyu Tang Professor, Xiangtan University, China Chunlai Tu Postdoctoral Associate, UIUC Qiuhao Qu IGB Fellow, UIUC Lichen Yin Professor, Soochow University Yanfeng Zhang Associate Professor, XiAn JiaoTong University Former Ph.D. graduate students Name Current Position Rong Tong Assistant Professor, Chemical Engineering, Virginia Tech Hua Lu Assistant Professor, Beijing University Li Tang CRI Irvington Postdoctoral Fellows at MIT with Prof. Darrell Irvine Jonathan Yen Scientist, Novartis Qian Yin Postdoc Fellow, Stanford University with Mark Davis Nan Zheng Postdoc Fellow, Texas A&M University Former MS graduate students Cheng-En Lai, M.S. (BIOE) Ellora Sen-Gupta, M.S. Qidi Sun, M.S. (CHEM E) Xiaojian Deng Yuyan Hua Isthier Chaudhury

Sr Engineer at Baxter International Inc. Biomedical Engineer. Senior Technician at Mondelēz International UIUC Dioxide Materials, Inc., Senior admissions officer, Univ. of Rochester, New York. 20

Rujing Zhang Zehao Song

Technical University of Denmark Computer Science, UIUC

Former Visiting Professor and Scholars Yanbing Lu (visiting professor, Hunan University, Hunan, China) Dr. Yuan Yao (visiting professor, Shanghai Jiaotong University, China) Dr. Yan Li (visiting professor, Tongji University, China) Zhonghai Zhang (visiting student, Tongji University, China) Former and current undergraduate students and research technicians (current position) Kevin Spencer (undergraduate) Jacqueline Handley (undergraduate) Jason Lang (undergraduate) Kyung Hoon Kim (undergraduate) George Li (Senior Research Specialist) Norman Thomas (undergraduate, ILLINOIS) Linda Yala (undergraduate, MCB, ILLINOIS) Alondra Cooper (undergraduate, ILLINOIS) Luis Lee (Monsanto) Matt Bossemeyer (Caterpillar) Chung Hee Moon (graduate student, Seoul National University) Kelley Kohnen (University of Chicago) Cynthia Lou William Storms (graduate student, the University of Akron) Kristine Yu Nguyen Vo Benjamin Teply (University of Nebraska Medical School) Josephine Sung Ines Sherifi (University of Toronto Medical School) Gaurav Luther (University of Chicago Medical School) Christophe Yim Seok Yoon Jeong Xin Jia (graduate student, University of California, Berkeley) Dennis Ho (graduate student, Harvard University) Huang Yao (undergraduate, ILLINOIS) Malini Ranganathan (Ph.D. UC-Berkeley 2010, currently UIUC Beckman Fellow) Yuxiao Wu (undergraduate) Jiawei Zhang (undergraduate) Yinzhao Huang (undergraduate Siyi Zhang (undergraduate) Chenchen Gu (undergraduate) Konrad M Ryba (undergraduate) Diane Kuai (undergraduate) Jiadi Xiong (undergraduate) STUDENT AWARDS -Hua Wang, HHMI International Graduate Student Fellowship 21

Curriculum Vitae

Jianjun Cheng

-Hanze Ying, Poster competition award, Garnet E. Peck Symposium In Industrial Pharmacy, 2015 -Hanze Ying, Illinois Technology Foundation Fifty for the Future Award, 2015 -Hanze Ying, 2015 Racheff-Intel Award for graduate student research, UIUC, 2015 -Hanze Ying, Conference Travel Award For Graduate Student, Graduate College, UIUC, 2014 -Ryan Baumgartner, Ullyot Fellowship, UIUC, 2014 -Qian Yin, Beckman Institute Graduate Fellow, UIUC, April, 2014 -Qian Yin, 2014 Racheff-Intel Award for graduate student research, UIUC, 2014 -Ryan Baumgartner, Robert Carr Fellowship, UIUC, 2013 -Hanze Ying, 3M Graduate Fellow Award, Materials Science and Engineering, UIUC,2013 -Kaimin Cai, 2013-2015, M-CNTC Graduate Fellowship, UIUC -Li Tang, CRI Irvington Postdoctoral Fellowship, 2013-2016 -Hua Lu, AkzoNobel Award for Outstanding Graduate Research in Polymer Chemistry (one student per year in US; one of the most prestigious awards in American Chemical Society), 2013 -Li Tang, 2012 Racheff-Intel Award, Department of Materials Science and Engineering, UIUC, April, 2012 -Qian Yin, 3M Graduate Fellowship of MatSE, UIUC, 2012. -Qian Yin received M-CNTC Graduate Fellowship, UIUC,2012 -Jonathan Yen, 2012 NSF Video and Poster Competition Award (May, 2012). -Li Tang: M-CNTC Fellowship -Vahid Mirshafiee: M-CNTC Fellowship -onathan Yen, IGERT Fellowship -Hua Lu, China Oversea Outstanding Graduate Student Award in 2011 -Hua Lu, Damon Runyon Postdoctoral Fellowship -Hua Lu: Racheff-Intel Award for graduate student research, UIUC, 2011 -Rong Tong, Akzo Nobel Award for Outstanding Graduate Research in Polymer Chemistry (only one student selected per year in US; one of the most prestigious awards in American Chemical Society), 2011 -Hua Lu, Yee Momorial Award, UIUC, 2010 -Hua Lu, The 6th Excellence in Graduate Polymer Research Symposium of American Chemical Society, San Francisco, CA, March 2010 -Rong Tong, 2009 Racheff-Intel Award for graduate student research, UIUC, 2009 -Rong Tong, Best Poster Award, Center for Nanoscale Science and Technology Nanotechnology Symposium, ILLINOIS, April, 2007 -Rong Tong, 2007 Siteman Center for Cancer Nanotechnology Excellence (SCCNE) Graduate Student Fellowship, ILLINOIS-Washington University THESIS COMMITTEE Sheeny Lan Chan Jerome Park Hee Kyung Sandeep Mariserla Abhijit Mishra

22

Curriculum Vitae

Jianjun Cheng

Richie Kohman Hulin Tu Scott Slimmer David Drake Wei Zhang Xijing Zhang Nikhil Ganesh Nathan Gabrilson Sara T. Parker Bo Wang Shan Jiang Jericho Moll Amit Patel Nihan Yonet-Tanyeri Kalena Stovall Rong Tong Hua Lu Xijing Zhang Jennifer Nicole Hanson Shepard Bo Hyun Lee Chaoyi Ba Yan Yu James Langer Xiaoxiang Zhu Sheeny Lan Zeba Parkar Jinwen Wang WeiZhang Brett A Beiermann Ying He Hang Xing Mo Jiang Ngo Yin Wong Piyush Bajaj Qian Chen Mark Eugene Hwang James Harold Herbison Li Huey Tan Hefei Dong Yaxuan Yao Li Tang Weihua Zheng Chunjie Zhang SukWon Hwang

23

Curriculum Vitae

Jianjun Cheng

Yugang Bai Pulin Wang Catherine M Possanza Qian Yin Hsuan-Chin Wang Jonathan Yen Richard C Webb PROFESSIONAL SOCIETY MEMBERSHIPS American Association for the Advancement of Science Society of Biomaterials American Society of Gene Therapy Materials Research Society Controlled Release Society American Chemical Society

2006-present 2005-present 2004-present. 2004-present 2002-present 1994-present

REFEREE OF GRANT PROPOSALS National Science Foundation National Institute of Health American Chemical Society Petroleum Research Fund Department of Defense US Civilian Research and Development Foundation Citrus Research and Development Foundation InNaBioSanté Foundation, France Qatar National Research Fund (QNRF), Qatar Foundation, Qatar "World Class University Project”, Technology Innovation Centers, Kingdom of Saudi Arabia Fundação para a Ciência e a Tecnologia, Lisboa, Portugal Singapore A*Star Research Grants Council (RGC) of Hong Kong FCT - Fundação para a Ciência e a Tecnologia, Portugal NATIONAL AND INTERNATIONAL SERVICES *Review Panel: NSF-DMR and NSF-CHE, 2007, 2008, 2009, 2011, 2012, 2013, 2014, 2015 *Review Panel: NIH-SBIR Study Section (2008), NIH-DT (2009), NIH-NANO (2015) *Chair: Symposium of “Gene and Drug Delivery”, Institute of Electrical and Electronics Engineers and the Engineering in Medicine and Biology Society (IEEE-EMBS) in Boston Review Panel: NSF-NCI joint review panel, Feb., 2011 *Symposium Chair: “Theme 7, Gene and Drug Delivery”, Institute of Electrical and Electronics *Engineers and the Engineering in Medicine and Biology Society (IEEE-EMBS), Sept., 2011 Symposium Chair: POLY “Polypeptide Biomaterials”, 239th American Chemical Society National Meeting, San Francisco, CA, March, 2010 *Reviewer of Citrus Research and Development Foundation, France, Jan., 2010 *Reviewer of Qatar National Research Fund (QNRF), Qatar Foundation, Qatar, Feb. 2009

24

Curriculum Vitae

Jianjun Cheng

*Reviewer of InNaBioSanté Foundation, France, Oct. 2008 *Review Panel: Breast Cancer Research Program, Congressionally Directed Medical Research Program, Department of Defense, 2007 and 2008 *Chair: Materials Research Society National Meeting. Symposium EE “Responsive Biomaterials for Medical Applications”, San Francisco, CA, March, 2008 *Ad hoc Reviewer of SBIR Study Section, NIH, March, 2008 *Session Chair: PMSE “Polypeptide Materials”, 234th American Chemical Society National Meeting, Boston, MA, July, 2007 UNIVERSITY SERVICE Steering Committee, M-CNTC Center, UIUC, 2014 Institutional Biosafety Committee, UIUC, 2014-2017 College of Engineering Safety Advisory Committee, 2014-2016 Faculty Recruitment Committee, MatSE, 2010-2012; 2013-2014 3M Fellowship Committee, MatSE, 2012, 2013 CNST Seminar Committee, 2009-2010 Senator Committee, UIUC, 2010-2012 Graduate Recruitment Committee, MatSE, 2010-present Colloquium Committee, Department of Materials Science and Engineering, 2006-2008 Curriculum Committee, Department of Materials Science and Engineering 2007-present Faculty Search Committee, Veterinary Clinical Medicine, 2007-2008 Discover Engineering Summer Camp, College of Engineering, ILLINOIS, 2006, 2007 Graduate Admission Committee, Dept. of Materials Science and Engineering, 2006 -2007 High School Open House, College of Engineering, Oct., 2005 High school workshop (Paxton and Buckley-Loda school), Nov. 2005 OTHER OUTREACH ACTIVITES *Helped high school students (Bishop Stang High School in North Dartmouth, Massachusetts, and Fairfield Ludlowe High School, Connecticut) to design science projects on self-healing materials for AP chemistry class (2014) *Participated in Engineering Opening House (EOH), UIUC (2014) *Participated in MatSE, UIUC, high school student visit (2006-now) *Participated in the Art of Science Program. One research image from our group was selected by a City of Chicago aviation department commissioner to be on display at O’Hare International Airport (2013) *Led Therapeutic Nanotechnology Lab module of Bionanotechnology Summer Institute, (2011-now) *Participated in Teacher summer workshop: nano@illinois Research Experience for Teachers (RET) (2014)

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