JAMES JOHN URBANIC, MD

JAMES JOHN URBANIC, MD OFFICE ADDRESS: UCSD Radiation Oncology, North County 1200 Garden View Road; Suite 210 Encinitas, CA 92024 [email protected] ME...
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JAMES JOHN URBANIC, MD OFFICE ADDRESS: UCSD Radiation Oncology, North County 1200 Garden View Road; Suite 210 Encinitas, CA 92024 [email protected] MEDICAL LICENSURE / BOARD CERTIFICATION: California #C131112 North Carolina #2008-00021 NPI #1164607875 American Board of Radiology – Radiation Oncology; Authorized User Radio-isotopes NCI Investigator #41789 EDUCATION: 1988-1992 B.S. United States Merchant Marine Academy, Kings Point, NY 1999-2003 M.D. Medical University of South Carolina, Charleston, SC POST GRADUATE TRAINING: 2003-2004 Intern, Internal Medicine; Medical University of South Carolina 2004-2007 Resident, Radiation Oncology; Wake Forest University Baptist Medical Center 2007-2008 Chief Resident, Radiation Oncology; Wake Forest University Baptist Medical Center EMPLOYMENT HISTORY: 1992-1995 Third Officer, US Navy, Military Sealift Command, Pacific 1995-1997 Assistant Engineer, T/V Kings Pointer, United States Merchant Marine Academy 1997-1998 Chief Engineer, T/V Kings Pointer, United States Merchant Marine Academy 2008-2014 Assistant Professor, Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC. 2014-current Medical Director, UCSD Radiation Oncology - North County; Associate Director, Division of Clinical and Translational Research, Department of Radiation Medicine and Applied Sciences, University of California San Diego, Moores Comprehensive Cancer Center La Jolla, CA. MILITARY: 1992-2002 Lieutenant (O-3), United States Naval Reserve AWARDS: 2014

2010-2014 2008

“Teacher of the Year Award” Department of Radiation Oncology as awarded by the radiation oncology residents and residency program for the 2013-2014 academic year. Best Doctors in America – published in “Business North Carolina” American Brachytherapy Society HDR Brachytherapy Fellowship Page 1 of 17

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James John Urbanic, MD 2008 2006 2005 2001-2002 2002 1992

ASCO Cancer Foundation Young Investigator Award RSNA Roentgen Resident/Fellow Research Award American Association for Cancer Research - Methods in Clinical Cancer Research Workshop, Vail Colorado Presidential Scholar, Medical University of South Carolina Alpha Omega Alpha Honor Medical Society Eugene F. Moran Award, United States Merchant Marine Academy

HOBBIES: Sailing, triathlons, soccer, tennis, playing with my kids MEMBERSHIP IN SOCIETIES: American Medical Association American Society for Radiation Oncology (ASTRO) American Society of Clinical Oncology North Carolina Medical Society International Association for the Study of Lung Cancer COOPERATIVE GROUP INVOLVEMENT: Alliance for Clinical Trials in Oncology (ALLIANCE) Clinical Trials: Urbanic, J Study Chair; Stinchcombe, T. Bogart, J; Vokes, E; CALGB 31102: Phase I study of Accelerated Hypofractionated Radiation Therapy with Concomitant Chemotherapy for unresectable Stage III Non-small Cell Lung Cancer. Activated February 2012. Brown, P Study Chair; Urbanic, J CALGB co-PI; Roberge, D NCIC co-PI. NCCTG N107C A Phase III Trial of Post-Surgical Stereotactic Radiosurgery (SRS) Compared with Whole Brain Radiotherapy (WBRT) for Resected Metastatic Brain Disease. Activated CTSU July 8, 2011. Committee Membership: Respiratory Committee Radiation Oncology Study Concept Review Committee (2013-2014) Institutional Performance Evaluation Committee Wake Forest Research Base Community Clinical Oncology Program Executive Steering Committee member – Wake Forest University Research Base Community Clinical Oncology Program 2010co-PI of Wake Forest Research Base Summer 2014; Funding award 8/1/2014. Radiation Therapy Oncology Group Gerber, D Study Chair; Langer, C; Urbanic, J Radiation Oncology PI; Lu, B. RTOG 1328 Randomized, Double Blinded Phase II Trial with Safety Lead In Page 2 of 17 30 September 2015

James John Urbanic, MD of Cisplatin and Etoposide Plus Thoracic Radiation Therapy Followed by Nivolumab/Placebo for Locally Advanced Non-Small Cell Lung Cancer. LOI Submitted to CTEP January 2014. RTOG Institutional PI, Wake Forest University. (2011-2014) NATIONAL COMMITTEES National Comprehensive Cancer Network (NCCN) -2014-current; member of Smoking Cessation Committee NCI Community Clinical Oncology Cardio-toxicity Task Force (2013-current): committee member American Society for Radiation Oncology – (IHE-RO) Integrating the Healthcare EnterpriseRadiation Oncology Committee Member 2011-2013 This is an ASTRO-sponsored initiative for improving the functionality of the radiation oncology clinic. The IHE-RO task force develops IHE Integration Profiles, which specify how industry standards are to be used to address specific clinical problems and ambiguities. These integration profiles are then tested at ASTRO’s annual Connectathon, where vendors meet to test the connectivity of their products. COURSE DIRECTOR: Principles and Practice of Image Guided Hypofractionated Stereotactic Body Radiotherapy First Course November 19 and 20th, 2009, most recent - September 11 and 12, 2014. Given in partnership between Wake Forest Radiation Oncology and Elekta Oncology. 2 to 3 times yearly with a world-wide audience. www.wakeforestsrt.com MENTORING: 2014 - “Teacher of the Year Award” Wake Forest School of Medicine, Department of Radiation Oncology as awarded by the radiation oncology residents and residency program for the 20132014 academic year. Translational Research Fellowship in Radiation Oncology, 2011-2014. Summer medical student project – 2011 and 2013. Mike Soike

ADMINISTRATIVE ACTIVITIES: University of California, San Diego; Department of Radiation Medicine and Applied Sciences Faculty Promotion Committee; Committee Chairman (2014-current) Wake Forest School of Medicine Faculty Representative Council 2013-2014 Wake Forest School of Medicine Faculty Compensation Committee 2013-2014

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James John Urbanic, MD Wake Forest Baptist Medical Center Radiation Safety Committee 2010 – 2013 Wake Forest Translational Radiation Oncology Fellowship Internal Advisory Board 2011 – 2014 NCI Funded T32 grant program supporting fellowship training to develop translational researchers in the fields of radiation biology and physics. Wake Forest Radiation Oncology Research Program 2011 - 2014 Director of program steering and oversight committee Wake Forest Thoracic Oncology Program 2011- 2014 Co-director of multi-disciplinary thoracic oncology program involving multiple providers across medical, surgical, and radiation oncology EDITORIAL POSITIONS: Senior Editor – Practical Radiation Oncology – effective January 2015. Assistant Editor – Frontiers in Oncology Invited Reviewer Journal of Thoracic Oncology Clinical Lung Cancer Practical Radiation Oncology Lung Cancer Abstract Reviewer American Society for Radiation Oncology (ASTRO) – annual meeting 2014 (lung cancer) WEBCASTS: http://www.youtube.com/watch?v=Ap4HV-3VBnY

CLINICAL TRIALS: Urbanic, J Study Chair; Stinchcombe, T. Bogart, J; Vokes, E; Phase I/II study of Accelerated Hypofractionated Radiation Therapy with Concomitant Chemotherapy for unresectable Stage III Non-small Cell Lung Cancer. Activated February 2012. Weaver, K Sudy Chair, Urbanic, J, Danhauer D, Case D; CCCWFU 99211 Feasibility of Delivering a Quitline Based Smoking Cessation Intervention in Lung Cancer Patients Receiving Outpatient Treatment: A Pilot Study. NCI approved for CCOP Research Base Activated January 2012. Urbanic, J Study Chair; Hu J co-PI; Cui Z; Wright JL; Case D; Shaw EG. CCCWFU 97609 Impact of Genomics and Exposures on Disparities in Breast Cancer Radiosensitivity. NCI approved for CCOP Research Base Activated September 2011. Brown, P Study Chair; Urbanic, J CALGB co-PI; Roberge, D NCIC co-PI. NCCTG N107C A Phase III Trial of Post-Surgical Stereotactic Radiosurgery (SRS) Compared with Whole Page 4 of 17 30 September 2015

James John Urbanic, MD Brain Radiotherapy (WBRT) for Resected Metastatic Brain Disease. Activated CTSU July 8, 2011. Urbanic JJ, Clark HP, et al. CCCWFU 62210 A Pilot Study of Cryoablation for Patients with Oligometastatic Cancer Involving the Lung, Opened March 2011. Closed February 2012. Urbanic, JJ, Rusthoven K, Blackstock AW, et al., CCCWFU 62110 Phase II Study of Consolidative Thoracic Radiotherapy and / or Stereotactic Body Radiation Therapy (SBRT) after First-Line Chemotherapy for Metastatic NSCLC. Opened August 2010. Urbanic JJ, Case, D, et al. CCCWFU 98110 A Randomized Phase II Dose Finding Study of ArginMax with or without Sildenafil For Its Effect on Erectile Function and Quality of Life in Survivors of Prostate Cancer Previously Treated with Radiotherapy. NCI approved protocol; Opened October 2010. Urbanic JJ, Clark H, Blackstock AW, et al. CCCWFU 62109 A Pilot Study of Interventional Thermal Ablation Combined with External Beam Radiation Therapy for Patients with Inoperable Non-Small Cell Lung Cancer > 3.5 cm in size Activated spring 2010. Closed Fall 2012 Clark H, Urbanic JJ, Blackstock AW, et al. CCCWFU 62306 A phase II study of radiofrequency ablation combined with external beam radiation therapy for patients with medically inoperable non-small cell lung cancer (Stage I) and the predictive value of positron emission tomography. IRB approved March 2007; closed June 2010. Stieber VW, Urbanic JJ, Blackstock AW, Hinson WH, Kearns WT, Robbins R, Clark P, Petty WJ, Miller A, Oaks T, Bourland JD. A Phase I/II Study of Hypofractionated Stereotactic Body Radiotherapy for Stage I/II Non-small Cell Lung Cancer within the Central Lung Region and the Prognostic Impact of 18FDG Positron Emission Tomography, CCCWFU 62206, Comprehensive Cancer Center, Wake Forest University, 2006. closed 2007

CLINICAL TRIAL FUNDING: Boston Scientific Corporation - CCCWFU 62306, 2007-2010 Cancer Challenge Grant – CCCWFU 62109, 2009-2011 Galil Medical – CCCWFU 62110, 2011 GRANTS: 2012-2014 Salary support (0.6 Calendar Months) – Comprehensive Cancer Center of WFU Community Clinical Oncology Program Research Base NCI CCOP Grant 3 U10 CA 081851 PI Ed Shaw 2012-2013 Salary Support - Subcontract under National Cancer Institute (NCI) Grant Award 5 Page 5 of 17 30 September 2015

James John Urbanic, MD U54 CA142152-04 (CFDA #93.397) between New Hanover Regional Medical Center and Wake Forest University Health Sciences. Improving Cancer Outcomes for Underserved Populations in SE North Carolina. PI P Maguire 2011-2014 Salary Support (1.068 Calendar Months) – Impact of Genomics on Disparities in Breast Cancer Radiosensitivity. CA135288 -8.9% annually PI Jennifer Hu; Wake Forest consortium PI Zheng Cui. 2010-2011 Salary support – Comprehensive Cancer Center of WFU Community Clinical Oncology Program Research Base NCI CCOP Grant 3 U10 CA 081851 PI Ed Shaw 2008-2009 American Society of Clinical Oncology Young Investigator Award, $50,000

INVITED LECTURES: American Society for Radiation Oncology (ASTRO) 2014 – Advanced Treatment Techniques for Non-small cell lung cancer - Review session at national meeting with Dr Jeff Bradley and Dr Indrin Chetty. September 2014, San Francisco CA. Discussant Scientific Session NN: Lung – Imaging and Locally Advanced Disease. American Society for Radiation Oncology (ASTRO) 2014 September 2014, San Francisco CA. American Society for Radiation Oncology (ASTRO) 2013 – Advanced Treatment Techniques for Non-small cell lung cancer - Review session at national meeting with Dr Jeff Bradley and Dr Indrin Chetty. September 2013, Atlanta GA. American Society for Radiation Oncology (ASTRO) 2012 – Advanced Treatment Techniques for Non-small cell lung cancer - Review session at national meeting with Dr Craig Stevens and Dr Indrin Chetty. October 2012, Boston, MA. World Conference on Interventional Oncology, June 2012; Chicago: Lung Cancer Tumor Board. World Conference on Interventional Oncology, June 2012; Chicago: SBRT – Competing or Complimentary to Surgery for Stage I Lung Cancer. North Carolina IMRT/IGRT Symposium, May 2012; Durham, NC: Liver SBRT: How We Do it, Case Presentation and Review of Literature. American Society for Radiation Oncology (ASTRO) 2011 – Advanced Treatment Techniques for Non-small cell lung cancer - Review session at national meeting with Dr Craig Stevens and Dr Indrin Chetty. October 2011, Miami Beach Fla.

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James John Urbanic, MD Society of Interventional Radiology 2011, Update on Radiation Therapy for Primary and Metastatic Lung Cancer. Categorical Course: Multidisciplinary Treatment of Lung Tumors. Chicago, March 2011. RSNA 2010 – Boost Session – Lung Cancer Review, Anatomy, Contouring, and Case Based Learning. Review session for radiation oncologist at national radiology meeting with Dr Jeff Bogart and Dr Ernie Scalizetti. December 2010. ASTRO 2010 – Using All the Tools – Stage 3 Lung Cancer - Review session at national meeting with Dr Craig Stevens and Dr Ellen Yorke. November 2010 North Carolina IMRT/IGRT Symposium, October 2010; Greensboro, NC: SBRT: Focus on Safety. Pink Ribbon Talks – Cancer Services, October 2010; Winston-Salem: Clinical Panel. World Conference on Interventional Oncology, June 2010; Philadelphia: Plenary Session – Lung Cancer Stereotactic Body Radiotherapy. World Conference on Interventional Oncology, June 2010; Philadelphia: Lung Cancer Tumor Board. World Conference on Interventional Oncology, June 2010; Philadelphia:How Do I Do it: Lung Cancer Stereotactic Radiotherapy. World Conference on Interventional Oncology, June 2010; Philadelphia: Synergies – Radiotherapy and Radiofrequency Ablation. High Point Regional Cancer Center – May 2010: Stereotactic Body Radiotherapy 2010 Update. Gibbs Regional Cancer Center Yearly Oncology Syposium; November 2009. Lung Stereotactic Body Radiotherapy – Promise and Uncertainty. Elekta Oncology 18th Annual Users Meeting; October 2009. Hypofractionated Lung Radiotherapy. ACRIN (American College of Radiology Imaging Network) Fall Meeting 2010. Combination therapy – RFA and radiotherapy. Ritz Carlton, Pentagon City, VA October 2010. Multimodality GI Oncology Conference – Second Annual; WFSOM/Northwest AHEC, June 2009. Is there a renewed role for radiotherapy in the management of liver tumors. Piedmont Oncology Association, March 2009; Evolving Role of Radiosurgery – Brain and Body.

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James John Urbanic, MD General Electric Medical Imaging, September 2008; Multimodality Imaging and Its Application to Radiation Oncology.

FACULTY LECTURES: Cardiothoracic Surgery Teaching Conference, February 2014; “Advances in Lung Cancer Radiotherapy.” Oncology Core Curriculum May 2013; “Radiotherapy for Lung Cancer Cardiothoracic Surgery Teaching Conference, November 2012; “Advances in Lung Cancer Radiotherapy.” New Directions in Oncology May 2012; “Clinical Trial Funding” Translational Radiation Oncology Fellowship program Cardiothoracic Surgery Teaching Conference, May 2011; “Stage I Lung Cancer - SBRT.” Oncology Core Curriculum May 2011; “Radiotherapy for Lung Cancer” New Directions in Oncology January 2011; “Opportunities in Metastatic Cancer” Translational Radiation Oncology Fellowship program Oncology Core Curriculum May 2010; “Radiotherapy for Breast Cancer” Cardiothoracic Surgery Teaching Conference, March 2010; “Advances in Radiotherapy for Lung Cancer.” Oncology Core Curriculum May 2009; “Radiotherapy for Lung Cancer” PUBLICATIONS: Lucas JT, Kuremsky JG, Soike M, Hinson W, Kearns WT, Blackstock AW, Urbanic JJ. Comparison of Accelerated Hypofractionation and Stereotactic Body Radiotherapy for Stage 1 & Node Negative Stage 2 Non-Small Cell Lung Cancer (NSCLC). Lung Cancer. 2014 Jul;85(1):59-65. PMID: 24813936 Kilburn, Jeremy M.; Lester, Scott C.; Lucas, John T. Jr; Soike, Michael H.; Blackstock, A. William; Kearns, William T.; Hinson, William H.; Miller, Antonius A.; Petty, William J.; Munley, Michael T.; Urbanic, James J. Management of Mediastinal Relapse after Treatment with Stereotactic Body Radiotherapy or Accelerated Hypofractionated Radiotherapy for Stage I/II Non–Small-Cell Lung Cancer. Journal of Thoracic Oncology. 9(4):572-576, April 2014. PMID 24736084. Ayala-Peacock DN, Peiffer AM, Lucas JT, Isom S, Kuremsky JG, Urbanic JJ, Bourland JD, Laxton AW, Tatter SB, Shaw EG, Chan MD. A nomogram for predicting distant brain Page 8 of 17 30 September 2015

James John Urbanic, MD failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. Neuro Oncol. 2014 Feb 20. [Epub ahead of print] PMID: 24558022 Kilburn JM, Ellis TL, Lovato JF, Urbanic JJ, Daniel Bourland J, Munley MT, Deguzman AF, McMullen KP, Shaw EG, Tatter SB, Chan MD. Local control and toxicity outcomes in brainstem metastases treated with single fraction radiosurgery: is there a volume threshold for toxicity? J Neurooncol. 2014 Feb 7. [Epub ahead of print] PMID: 24504497

Kilburn JM, Kuremsky JG, Blackstock AW, Munley MT, Kearns WT, Hinson WH, Lovato JF, Miller AA, Petty WJ, Urbanic JJ. Thoracic re-irradiation using stereotactic body radiotherapy (SBRT) techniques as first or second course of treatment. Radiother Oncol. 2014 Mar;110(3):505-10. PMID: 24444530 Salama JK, Pang H, Bogart JA, Blackstock AW, Urbanic JJ, Hodgson L, Crawford J, Vokes EE Predictors of pulmonary toxicity in limited stage small cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904. Lung Cancer. 2013 Dec;82(3):436-40. PMID: 24396884 Kuremsky J, Urbanic JJ, Jeff Petty W, Lovato JF, Bourland JD, Tatter SB, Ellis TL, McMullen KP, Shaw EG, Chan MD. Tumor Histology Predicts Patterns of Failure and Survival in Patients with Brain Metastases from Lung Cancer Treated with Gamma Knife Radiosurgery. Neurosurgery. 2013 Oct; 73(4):641-7. PMID: 23842552. PMCID – in process. Salama JK, Hodgson L, Pang H, Urbanic JJ, Blackstock AW, Schild SE, Crawford J, Bogart JA, Vokes EE; for the Cancer and Leukemia Group B. A Pooled Analysis of Limited-Stage Small-Cell Lung Cancer Patients Treated with Induction Chemotherapy Followed by Concurrent Platinum-Based Chemotherapy and 70 Gy Daily Radiotherapy: CALGB 30904. J Thorac Oncol. 2013 Aug;8(8):1043-1049. PMID: 23715301. PMCID: PMC3822578 Patel PR, Yoo DS, Niibe Y, Urbanic JJ, Salama JK. A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer. Pulm Med. 2012;2012:480961. doi: 10.1155/2012/480961. Epub 2012 Oct 17. PMCID: PMC3483729 Loganathan AG, Chan MD, Alphonse N, Peiffer AM, Johnson AJ, McMullen KP, Urbanic JJ, Saconn PA, Bourland JD, Munley MT, Shaw EG, Tatter SB, Ellis TL. Clinical outcomes of brain metastases treated with Gamma Knife radiosurgery with 3.0 T versus 1.5 T MRIbased treatment planning: have we finally optimised detection of occult brain metastases? J Med Imaging Radiat Oncol. 2012 Oct;56(5):554-60. doi: 10.1111/j.1754-9485.2012.02429.x. Epub 2012 Jul 30. PMID: 23043576 Vern-Gross TZ, Lawrence JA, Case LD, McMullen KP, Bourland JD, Metheny-Barlow LJ, Ellis TL, Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery. J Neurooncol. 2012 Dec;110(3):381-8. doi: 10.1007/s11060-012-0976-3. Epub 2012 Sep 24. PMID: 23001361 Page 9 of 17 30 September 2015

James John Urbanic, MD Cochran DC, Chan MD, Aklilu M, Lovato JF, Alphonse NK, Bourland JD, Urbanic JJ, McMullen KP, Shaw EG, Tatter SB, Ellis TL. The effect of targeted agents on outcomes in patients with brain metastases from renal cell carcinoma treated with Gamma Knife surgery. J Neurosurg. 2012 May;116(5):978-83. Epub 2012 Mar 2. PMID: 22385005. PMCID: PMC3791504

Harris S, Chan MD, Lovato JF, Ellis TL, Tatter SB, Bourland JD, Munley MT, deGuzman AF, Shaw EG, Urbanic JJ, McMullen KP. Gamma Knife stereotactic radiosurgery as salvage therapy after failure of whole brain radiotherapy with small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):e53-9. Epub 2012 Feb 17. PMID: 22342297. PMCID: PMC3791505

Petty WJ, Voelzke WR, Urbanic JJ, Varela VA, Waller LL, Swift CB, Graham RM, Memoli VA, Dragnev KH. High cyclin D3 expression confers erlotinib resistance in aerodigestive tract cancer. Lung Cancer. 2011 Dec; 74(3): 384-91. PMID: 21555162 Lowell D, Tatter SB, Bourland JD, Deguzman AF, Ekstrand KE, Ellis TL, Lovato JF, McMullen KP, Munley MT, Shaw EG, Urbanic JJ, Chan MD. Toxicity of gamma knife radiosurgery in the treatment of intracranial tumors in patients with collagen vascular disease or multiple sclerosis. Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4): e519-24. PMID: 21601376 Jensen CA, Chan MD, McCoy TP, Bourland JD, Deguzman AF, Ellis TL, Ekstrand KE, McMullen KP, Munley MT, Shaw EG, Urbanic JJ, Tatter SB. Cavity-directed radiosurgery as adjuvant resection of a brain metastasis. J Neurosurg 2011 June; 114(6): 1585-91. PMID 21166567. PMCID: PMC3789371 Urbanic JJ, Lally B, Blackstock AW. The best laid plans often go …. Awry. J Thoracic Oncology 2009 4(7): 783-4. PMID 19550240 Lally BE, Urbanic JJ, Blackstock AW. Could it be that less is more? Lancet Oncology 2009; 10(5): 435-7. PMID 19410187 Lally BE, Geiger AM, Urbanic JJ, Butler JM, Wentworth S, Perry MC, Wilson LD, Horton JK, Detterbeck FC, Miller AA, Thomas CR, Blackstock AW. Trends in the outcomes for patients with limited stage small cell lung cancer: An analysis of the Surveillance, Epidemiology, and End Results database. Lung Cancer 2009; 64(2); 226-31. PMID 18835059 Rossi PJ, Urbanic J, Clark PE, McCullough DL, Lee WR. Pretreatment PSAV is associated with freedom from biochemical recurrence of prostate cancer after low dose rate prostate brachytherapy alone. Brachytherapy 2008; Oct-Dec: 7(4): 286-289. PMID 18928924 Urbanic JJ, Lally BE, Blackstock AW. Preoperative Chemoradiotherapy for Superior Sulcus Tumors: JCOG 9806 Validation of an Induction Therapy Approach. Amer J Hem Oncol (Review) 2008. Kearns WT, Urbanic JJ, Hampton CJ, McMullen KP, Blackstock AW, Stieber VW., Hinson WH. Radiation safety issues with PET/CT simulation for Stereotactic Body Radiation Page 10 of 17 30 September 2015

James John Urbanic, MD Therapy. Journal of Applied Clinical and Medical Physics 2008; 9(3): 141-146. PMID 18716587 Lally BE, Urbanic JJ, Blackstock AW, Miller AA, Perry MC. Small cell lung cancer: Have we made any progress over the last 25 years? Oncologist 2007 Sept; 12(9):1096-104. PMID 17914079 Papagikos MA, Rossi PJ, Urbanic JJ, deGuzman AF, McCullough DL, Clark PE, Lee WR. A simple model predicts freedom from biochemical recurrence following low-dose-rate prostate brachytherapy alone. Am J Clin Oncol 2007 April; 30: 199-204. PMID 17414471 Urbanic JJ, Lee WR. Confidence Intervals and Survival Estimates: A systematic review of three oncology journals. Am J Clin Oncol 2006 Aug; 29: 405-407. PMID 16891871 Urbanic JJ, Blackstock AW. Radiotherapy for Small Cell Lung Cancer. American Society of Clinical Oncology Annual Meeting Educational Book 2006; 442-444. Urbanic JJ, Lee WR. Update on brachytherapy in prostate cancer: The importance of dosimetry. Curr Opin Urol 2006 May; 16: 157-161. PMID 16679852 Urbanic JJ, Turrisi AT, Sharma AK, Silvestri GA, Williams TE, Vanek KN, Sherman CA. Conformal high-dose external radiation therapy (CHERT), 80.5 Gy, alone for medically inoperable non-small cell lung cancer (MILC) - a retrospective analysis. J Thoracic Oncol 2006 Feb; 1: 112-119. PMID 17409839 Rocha Lima CM, Urbanic JJ, Lal A, Kneuper-Hall R, Brunson CY, Green MR. Beyond pancreatic cancer: irinotecan and gemcitabine in solid tumors and hematologic malignancies. Semin Oncol 2001 Jun; 28(3 Suppl 10): 34-43. PMID 11510032 Rocha Lima CM, Urbanic JJ, Sherman CA, Brescia FJ, Green MR. Docetaxel followed by gemcitabine and irinotecan in solid tumors. Oncology(Huntingt). 2001 Jan; 15(1 Suppl 1):3745. PMID 11221020

PRESENTATIONS: J.J. Urbanic, D. Case, G. Lesser, G. Enevold, M. Naughton, S. Danhauer, S. Rapp, M. Vitolins, E Shaw. L-arginine–Based Nutritional Supplement Did Not Improve Erectile Function or Quality of Life in Prostate Cancer Survivors Previously Treated With Radiation Therapy: Results of CCOP Research Base Protocol 98110 – A Randomized Phase 2 Dose Finding Study. International Journal of Radiation Oncology • Biology • Physics, Vol. 90, Issue 1, S86– S87 (ASTRO 2014 - Oral Presentation) J.M. Kilburn, J.T. Lucas, M.H. Soike, D. Ayala-Peacock, J.G. Kuremsy, A. Blackstock, W.H. Hinson, A.A. Miller, JJ Urbanic. Which Lung Tumors Shrink During Fractionated

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James John Urbanic, MD Radiation and How Does This Influence Outcome?: Appropriately Selecting Tumor and Treatment Characteristics for Adaptive Radiation Therapy Protocols International Journal of Radiation Oncology • Biology • Physics, Vol. 90, Issue 1, S641–S642 (ASTRO 2014 Poster) S.C. Lester, J.M. Kilburn, J.T. Lucas, M.H. Soike, A.W. Blackstock, W.H. Hinson, A.A. Miller, W.J. Petty, JJ Urbanic. An Evaluation of Toxicity Using Accumulated Total Dose Based on EQD2 for Thoracic Reirradiation Incorporating at Least 1 Course of SBRT. International Journal of Radiation Oncology • Biology • Physics, Vol. 90, Issue 1, S640–S641 (ASTRO 2014 Poster) G.M. Videtic, C. Hu, A. Singh, J.Y. Chang, W. Parker, K. Olivier, S. Schild, R. Komaki, J. Urbanic, H. Choy. Radiation Therapy Oncology Group (RTOG) Protocol 0915: A Randomized Phase 2 Study Comparing 2 Stereotactic Body Radiation Therapy (SBRT) Schedules for Medically Inoperable Patients With Stage I Peripheral Non-Small Cell Lung Cancer. International Journal of Radiation Oncology*Biology*Physics, Volume 87, Issue 2, Supplement, 1 October 2013, Page S3 (ASTRO 2013 – Oral Clinical Trials Session) J.M. Kilburn, S.C. Lester, J.T. Lucas, A.W. Blackstock, W.T. Kearns, W.H. Hinson, M.T. Munley, A.A. Miller, W.J. Petty, J.J. Urbanic. Multiple Courses of Thoracic Radiation Therapy (XRT) Using Stereotactic Body Radiation Therapy (SBRT) as the First or Second Course of Treatment for Tumors Outside the Original High-Dose Region. International Journal of Radiation Oncology*Biology*Physics, Volume 87, Issue 2, Supplement, 1 October 2013, Page S36 (ASTRO 2013 – Oral) J.T. Lucas, H.G. Colmer, G.L. White, S.P. Isom, T.L. Ellis, J.J. Urbanic, S.B. Tatter, M.D. Chan. A Competing Risk Analysis of Neurologic Versus Nonneurologic Death in Patients Undergoing Radiosurgical Salvage Following Whole Brain Radiation Therapy Failure (WBRT): Who Actually Dies of Their Brain Metastases? International Journal of Radiation Oncology*Biology*Physics, Volume 87, Issue 2, Supplement, 1 October 2013, Page S52. (ASTRO 2013 – Oral) M. Soike, J.M. Kilburn, J.T. Lucas, D. Ayala-Peacock, A.W. Blackstock, W.T. Kearns, W.H. Hinson, A.T. Miller, W.J. Petty, J.J. Urbanic. Image Guided Radiation Therapy Results in Improved Local Control in Lung Cancer Patients Treated With Fractionated Radiation Therapy for Stage IIB-IIIB Disease. International Journal of Radiation Oncology*Biology*Physics, Volume 87, Issue 2, Supplement, 1 October 2013, Pages S547S548. (ASTRO 2013 – Poster) S.C. Lester, J.M. Kilburn, J.T. Lucas, M.T. Munley, A.W. Blackstock, W.T. Kearns, W.H. Hinson, A.A. Miller, W.J. Petty, J.J. Urbanic. Salvage Radiation for Mediastinal Relapse After Treatment With Accelerated Hypofractionated Radiation Therapy (AHRT) or Stereotactic Body Radiation Therapy (SBRT) for Stage I/II NSCLC International Journal of Radiation Oncology*Biology*Physics, Volume 87, Issue 2, Supplement, 1 October 2013, Pages S543-S544 (ASTRO 2013 – Poster)

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James John Urbanic, MD

J.M. Kilburn, J.T. Lucas, M.H. Soike, D. Ayala-Peacock, A.W. Blackstock, W.T. Kearns, W.H. Hinson, A.A. Miller, W.J. Petty, J.J. Urbanic. Is a Clinical Target Volume (CTV) Necessary in Treatment of Thoracic Malignancies Treated in the Modern Era Combining 4-D Imaging and Image Guided Radiation Therapy (IGRT)? International Journal of Radiation Oncology*Biology*Physics, Volume 87, Issue 2, Supplement, 1 October 2013, Page S549 (ASTRO 2013 – Poster) D.N. Ayala-Peacock, A.W. Blackstock, W.T. Kearns, W.H. Hinson, M.T. Munley, A.A. Miller, W.J. Petty, J.J. Urbanic. Stereotactic Body Radiation Therapy (SBRT) and Image Guided Accelerated Hypofractionated Radiation Therapy (IGAHRT) for the Treatment of Oligometastatic Cancers International Journal of Radiation Oncology*Biology*Physics, Volume 87, Issue 2, Supplement, 1 October 2013, Pages S567-S568. (ASTRO 2013 – Poster) S. Garg, J.M. Kilburn, D.M. Randolph, J.T. Lucas, J.J. Urbanic, M. Porosnicu, W.H. Hinson, W.T. Kearns, K.M. Greven. Re-irradiation for Second Primary or Recurrent Cancers of the Head and Neck: Composite Dosimetric Measures to Evaluate Dose to the Carotid Arteries. International Journal of Radiation Oncology*Biology*Physics, Volume 87, Issue 2, Supplement, 1 October 2013, Pages S480-S481. ASTRO 2013 (Poster) Urbanic JJ, Case D, Naughton MJ, Hu JJ, Enevold G, Beech B, Weaver K, Danhauer S, Rapp S, Sheidler V, Vitolins M, Lesser G, Shaw E. Minority accrual on a prospective study targeting a diverse U.S. breast cancer population: An analysis of Wake Forest CCOP research base protocol 97609. J Clin Oncol 31, 2013 (suppl; abstr 6564). (ASCO 2013 Poster) J.G. Kuremsky, W.J. Petty, A. Miller, W.H. Hinson, C.J. Hampton, A.W. Blackstock, J.J. Urbanic. Hypofractionated Radiation Therapy for Stage I and II Non-small Cell Lung Cancer. International Journal of Radiation Oncology*Biology*Physics, Volume 84, Issue 3, Supplement, 1 November 2012, Pages S153-S154 (ASTRO 2012 - Oral) J.J. Urbanic, M. Soike, C.J. Hampton, J. Lucas, W. Hinson, W. Kearns, A.W. Blackstock. Long-term Follow-up and Patterns of Failure for Patients With Medically Inoperable Stage I Non-small Cell Lung Cancer (NSCLC) Treated With Stereotactic Body Radiation Therapy (SBRT) International Journal of Radiation Oncology*Biology*Physics, Volume 84, Issue 3, Supplement, 1 November 2012, Page S609 (ASTRO 2012 – Poster) C.J. Hampton, A. Baydush, J.J. Urbanic. Is a Single IGRT Localization Followed by a Planned Isocenter Shift Sufficient to Accurately Localize Multi-isocenter SBRT Targets? International Journal of Radiation Oncology*Biology*Physics, Volume 84, Issue 3, Supplement, 1 November 2012, Page S828 (ASTRO 2012 – Poster) D. Ayala-Peacock, A.M. Peiffer, T.L. Ellis, S.B. Tatter, J.J. Urbanic, J.D. Bourland, E.G. Shaw, M.D. Chan Predictive Factors for Distant Brain Failure After Primary Radiosurgical Management of Brain Metastases. International Journal of Radiation Oncology*Biology*Physics, Volume 84, Issue 3, Supplement, 1 November 2012, Page S296 (ASTRO 2012 – Poster) Page 13 of 17 30 September 2015

James John Urbanic, MD J.M. Kilburn, J.G. Kuremsky, A.W. Blackstock, W.T. Kearns, C.J. Hampton, W.H. Hinson, A.A. Miller, W.J. Petty, J.J. Urbanic. Thoracic Reirradiation in Patients With Stereotactic Body Radiation Therapy (SBRT) as First or Second Course of Treatment. International Journal of Radiation Oncology*Biology*Physics, Volume 84, Issue 3, Supplement, 1 November 2012, Page S604 (ASTRO 2012 - Poster) J.M. Kilburn, J.G. Kuremsky, A.W. Blackstock, W.T. Kerans, W.H. Hinson, C.J. Hampton, W.J. Petty, A Miller, J.J. Urbanic. Thoracic Re-irradiation in Patients with Stereotactic Body Radiotherapy (SBRT) As First Or Second Course of Treatment. Multidisciplinary Symposium in Thoracic Oncology Abstr 212. Chicago, Journal of Thoracic Oncology Vol 7 (9); S253, September 2012. J.T. Lucas, J.G. Kuremsky, M Soike, W. Hinson, W.T. Kearns, C.J. Hampton, A.W. Blackstock, J.J. Urbanic. Comparison of Accelerated Hypofractionation and Stereotactic Body Radiotherapy for Stage 1 & 2 Non-small Cell Lung Cancer. Multidisciplinary Symposium in Thoracic Oncology Abstr 143. Chicago, Journal of Thoracic Oncology Vol 7 (9); S228, September 2012. J.G. Kuremsky, W.J. Petty, A Miller, W.H. Hinson, C.J. Hampton, A.W. Blackstock, J.J. Urbanic. Hypofractionated Radiotherapy for Stage I and II Non-small Cell Lung Cancer. Multidisciplinary Symposium in Thoracic Oncology Abstr 148. Chicago, Journal of Thoracic Oncology Vol 7 (9); S230, September 2012. J. Meyer, J. Urbanic, B Steadman, J.A. Requart, D Childs, H. Clark Long-Term Outcomes of Thermal Ablation for Metastatic Tumors in the Lung. World Conference of Interventional Oncology 2012, Chicago. (oral) J.G. Mammarappallil, C Sullivan, J.J. Urbanic, M Porosnicu, J Meyers, H.Clark. Cryotherapy as Salvage Therapy of Locally Recurrent Squamous Cell Laryngeal Cancer. World Conference of Interventional Oncology 2012, Chicago. (poster) T.Z. Vern-Gross, K.P. McMullen, L.D. Case, J.D. Bourland, T.L. Ellis, J.A. Lawrence, S.B. Tatter, E.G. Shaw, J.J. Urbanic, M.D. Chan. Patterns of failure in patients receiving gamma knife radiosurgery for breast carcinoma. International Journal of Radiation Oncology*Biology*Physics, Volume 81, Issue 2, Supplement, 1 October 2011, Pages S216S217. ASTRO 2011. J.M. Kilburn, T.L. Ellis, J.J. Urbanic, J.D. Bourland, M.T. Munley, A.F. deGuzman, K.P. McMullen, E.G. Shaw, S.B. Tatter, M.D. Chan. Outcomes for gamma knife radiosurgery for brainstem metastases. International Journal of Radiation Oncology*Biology*Physics, Volume 81, Issue 2, Supplement, 1 October 2011, Page S302. ASTRO 2011. J.G. Kuremsky, J.J. Urbanic, W.J. Petty, J.F. Lovato, J.D. Bourland, S.B. Tatter, T.L. Ellis, K.P. McMullen, E.G. Shaw, M.D. Chan. Tumor histology predicts pattern of failure and survival in patients with lung cancer treated with gamma knife radiosurgery. International Journal of

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James John Urbanic, MD Radiation Oncology*Biology*Physics, Volume 81, Issue 2, Supplement, 1 October 2011, Page S595. ASTRO 2011. W. Jeffrey Petty, Victor A. Varela, Catherine B. Swift, and James J. Urbanic. A role for angiotensin converting enzyme inhibition in lung cancer chemoprevention. WCAO 2011. J. K. Salama, L. Hodgson, H. Pang, M. R. Green, J. J. Urbanic, A. W. Blackstock, J. Crawford, J. Bogart, E. E. Vokes. Predictors of pulmonary toxicity in limited-stage (LS) small cell lung cancer (SCLC) patients treated with concurrent chemotherapy (CTX) and high-dose (70 Gy) daily radiotherapy (RT): A pooled analysis of three CALGB studies. ASCO Abstract (Poster) 2011. J Clin Oncol 29: 2011 (suppl; abstr 7078) Baskin R, Urbanic J, Russell G, Levine E. The Effect of Preoperative Chemotherapy Prior to Complete Resection or Stereotactic Body Radiotherapy (SBRT) of Pulmonary Metastasis from Sarcoma. Society of Surgical Oncology (Poster) 2011. McMullen KP, Harris S, Lovato J, Ellis TL, Tatter SB, Urbanic J, Bourland JD, Shaw EG, Chan MC. Salvage Radiosurgery for Patients with Small Cell Lung Cancer after Previous Whole Brain Radiation. ASTRO 2010, San Diego (poster). Ge G, Urbanic JJ, Lovato J, Bettman M, Entrikin D, Oaks T, Cappellari JO, Clark HP. Increased Diagnostic Yield with CT Fluoroscopy Compared to Conventional CT Guided Fine Needle Aspiration and/or Biopsy: A Retrospective Analysis of > 1000 Procedures. WCIO 2010, Philadelphia (Oral). Wagner JS, Sandifer V, Chin R, Urbanic J, Oaks T, Clark H, Peacock JE, Cappellari J, Sollenberger M. Image Guided Radiology Provides Image-Guided Ablation as a Novel Therapy for Ectopic Adrenocorticotropin Hormone Syndrome. WCIO 2010, Philadelphia (Poster). Urbanic JJ, Clark HP, Case D, Hinson WH, Kearns WT, Hampton CJ, Chiles C, Crowley M, Clark P, Blackstock AW. Initial Toxicity Report of a Phase II Study of Radiofrequency Ablation Combined with External Beam Radiation Therapy for Patients with Medically Inoperable Non-Small Cell Lung Cancer (Stage Ia and select Ib). ASTRO 2009, Chicago (Poster). Squire SE, Lee WR, Urbanic JJ, DeGuzman AF, King J, Papagikos MA, Rossi PJ, Clark PE, McCullough DL, Fried DB. Low-Dose-Rate Prostate Brachytherapy: Predictors of Freedom From Biochemical Recurrence. ASTRO 2009, Chicago (Poster). Urbanic JJ, McMullen KP, Stieber VW, Hinson WH, Kearns WT, Hampton CJ, Lovato JF, Livengood K, Rosdahl R, Blackstock AW. A Phase I/II Dose-Escalation/Efficacy Study of Single Fraction Stereotactic Body Radiotherapy (SF-SBRT) for Metastatic Cancer. ASTRO 2008, Boston (Poster with Discussion).

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James John Urbanic, MD C.J. Hampton, W.T. Kearns, J.J. Urbanic, K.P. McMullen, A.W. Blackstock, W.H. Hinson Impact of Individualized Target Volumes on Stereotactic Body Radiotherapy Treatment Planning (SBRT): Volumetric Analysis. International Journal of Radiation Oncology*Biology*Physics, Volume 72, Issue 1, Supplement, 1 September 2008, Page S617 ASTO 2008 (Poster) Urbanic JJ, Fried D, Case, D, et al. A Phase III Study of Sildenafil with ArginMax and Their Effect on Male Sexual Function and Quality of Life in Survivors of Pelvic Malignancies CCCWFU/CCOP Research Base Annual Meeting, Asheville NC, 2007. Urbanic JJ, Hinson W, Stieber VW, et al. Heterogeneity corrections in stereotactic body radiotherapy (54 Gy in 3 fractions) significantly alter delivered dose. Poster presentation ASTRO Translational Research Meeting September 2007. Hinson WH, Kearns WT, Hampton CJ, Urbanic JJ, McMullen KP, Blackstock AW, Stieber VW. “SBRT Simulations using PET/CT: Radiation Safety Concerns.” Presented at 49th Annual Meeting of the American Association of Physicists in Medicine, Minneapolis, Minnesota, July, 2007. Petty WJ, Voelzke WR, Memoli VA, Dragnev KV, Urbanic J, Rigas JR, Dmitrovsky E. Expression of cyclin D3 confers resistance to erlotininb. ASCO 2007. Urbanic JJ, Hinson W, Stieber VW, et al. Heterogeneity corrections in stereotactic body radiotherapy (54 Gy in 3 fractions) significantly alter delivered dose. Poster presentation ASTRO 2006. Lally BE, Urbanic JJ, Butler JM, Wentworth S, Thomas CR, Blackstock AW. Outcomes of patients with limited-stage small cell lung cancer treated with radiotherapy: Analysis of data from the Surveillance, Epidemiology, and End-Results (SEER) program. Oral Presentation ASTRO 2006. Wentworth S, Lally BE, D'Agostino R, Urbanic JJ, Butler JM, Paskett E, Blackstock AW. Impact of Race on Survival and Radiotherapy Use in Patients with Non-Metastatic Rectal Cancer: Analysis of Data from the Surveillance, Epidemiology and End-Results (SEER) Program. Oral Presentation ASTRO 2006. Butler JM, Lally BE, D'Agostino R, Urbanic JJ, Wentworth S, Paskett E, Blackstock AW. Impact of race and marital status on survival and stage at presentation for patients with colorectal cancer: An analysis of data from the Surveillance, Epidemiology, and EndResults (SEER) program. Oral Presentation ASTRO 2006. Kearns WT, Hinson WH, Hampton CJ, Butler JM, Urbanic JJ, Starnes D, deGuzman AF, Stieber VW. Radiation safety issues with PET/CT simulation for stereotactic body radiotherapy. Poster Presentation ASTRO 2006.

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James John Urbanic, MD Urbanic JJ, Lee WR. Kaplan Meyer estimates of survival without confidence intervals: a systematic review of three oncology journals. Int J Radiat Oncol Biol Phys 2005; 63 (Suppl 1): S435 (Abstr 2348). Poster Presentation ASTRO 2005. Urbanic JJ, Turrisi A, Sharma A, et al. Conformal high dose external radiotherapy (CHERT) alone for medically inoperable lung cancer (MILC). 11th World Conference on Lung Cancer (IASLC - Barcelona Spain) Lung Cancer 2005; 49(suppl 2):S102. Poster Presentation with Discussion. Urbanic JJ, Turrisi A, Sharma A, et al. Conformal high dose external radiotherapy (CHERT) alone for medically inoperable lung cancer (MILC). Proc Amer Soc Clin Oncol (2004); 23:670 (Abst 7228). - Poster Presentation ASCO 2004.

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