THE

KURUME

MEDICAL

Vol. 37, p. 97-104,

JOURNAL

1990

Inhibitory

Effect

to Athymic

of Antineoplaston

Mice

and

Human

A-10

on Breast

Hepatocellular

Cancer

Carcinoma

Hideaki Tsuda and # the Members of Antineoplaston Kurume University School of Medicine, Kurume, Received

for

Publication

Transplanted

March

9,

Cell

Lines

Study Group, 830 Japan

1990

Summary : The inhibitory effect of Antineoplaston A- 10 was tested on the growth curve of human breast cancer (R- 27) serially transplanted to athymic mice and on the cell growth of human hepatocellular carcinomas (KMCH-1, KYN-1, KIM-1). Approximately 1.25°0 of Antineoplaston A-10 in the regular mouse diet (CE2) inhibited the growth curve significantly after 35 days treatment (pCo. 05). Seventy milligrams of daily intraperitoneal administration of Antineoplaston A-10 Injection also inhibited the growth curve of R-27 after 52 days treatment (p