SAFETY DATA SHEET
1. Identification Product identifier Other means of identification Synonyms
AQUAFRESH TOOTHPASTE
Recommended use
SODIUM FLUORIDE, FORMULATED PRODUCT * SEE SYNONYMS ANNEX AFTER SECTION 16 Oral Care
Recommended restrictions
No other uses are advised.
Manufacturer/Importer/Supplier/Distributor information Manufacturer GlaxoSmithKline Canada Canadian Head Office 7333 Mississauga Road Mississauga, Ontario L5N 6L4 Canada General Information Phone Number (normal business hours): 905-819-3000 Consumer Healthcare Product Inquiries (toll free): 1-800-250-8866 Pharmaceutical, Stiefel, and Vaccine Inquiries (toll free): 1-800-387-7374 ----------------------------------------------------------------------------------------CHEMTREC TRANSPORTATION EMERGENCY NUMBERS Customer Number: CCN9484 (available 24hrs/7days: multi-language response) International Toll Call +(1) 703 527 3887 Email Address:
[email protected] Website: www.gsk.com Supplier
Not available.
2. Hazard(s) identification Classified hazards Exempt from requirements - product regulated as a medicinal product, cosmetic product or medical device. Label elements Exempt from requirements - product regulated as a medicinal product, cosmetic product or medical device. Exempt from requirements - product regulated as a medicinal product, cosmetic product or medical device.
3. Composition/information on ingredients Mixtures Chemical name
Common name and synonyms
CAS number
%
GLYCERIN
Glycerol GLYCERIN ANHYDROUS Glycerine GLYCERITOL GLYCYL ALCOHOL 1,2,3-Propanetriol PROPANETRIOL GLYROL GLYSANIN TRIHYDROXYPROPANE 1,2,3-TRIHYDROXYPROPANE OSMOGLYN
56-81-5
0 - 50
10279-57-9
0 - 25
SILICA, AMORPHOUS HYDRATED SILCON DIOXIDE HYDRATE SILICA, HYDRATE HYDRATED AMORPHOUS SILICA Zeodent 113 Zeodent 153 Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
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Issue date: 15-July-2016
1 / 19
Chemical name
Common name and synonyms
CAS number
%
471-34-1
0 - 21
Calcium carbonate
CARBONIC ACID, CALCIUM SALT CALCIUM MONOCARBONATE PRECIPITATED CALCIUM CARBONATE CHALK
Quartz
ALPHA-QUARTZ Silicon dioxide SILICON DIOXIDE (QUARTZ) Silica SILICIC ANHYDRIDE CRYSTALLINE SILICA
14808-60-7
0 - 16
TIXOSIL
SILICA GEL, CRYSTAL-FREE SILICA, AMORPHOUS: SILICA GEL
Unassigned
0 - 16
Silicon dioxide
Silica Silica gel Amorphous silica DIATOMACEOUS EARTH INFUSORIAL EARTH CAB-O-SIL M-5
7631-86-9
0 - 14
ZEODENT 124
Silica [inhalable fraction] Silicon dioxide (crystalline) (Silica) SILICA, AMORPHOUS, FUMED SILICIC ANHYDRIDE
7631-86-9
0 - 11.5
SODIUM TRIPOLYPHOSPHATE
Triphosphoric acid, pentasodium salt PENTASODIUM TRIPHOSPHATE PENTASODIUM TRIPOLYPHOSPHATE SODIUM TRIPHOSPHATE SODIUM POLYPHOSPHATE SODIUM PHOSPHATE
7758-29-4
0 - 10
Potassium nitrate
Nitric acid potassium salt NITRIC ACID POTASSIUM SALT (1:1)
7757-79-1
0-5
7631-86-9
0-5
SIDENT Propylene glycol
1,2-Propanediol 1,2-DIHYDROXYPROPANE 2-HYDROXYPROPANOL ISOPROPYLENE GLYCOL METHYLETHYLENE GLYCOL METHYLETHYL GLYCOL MONOPROPYLENE GLYCOL 2,3-PROPANEDIOL ALPHA-PROPYLENE GLYCOL 1,2-PROPYLENE GLYCOL (RS)-1,2-PROPANEDIOL 1,2-(RS)-PROPANEDIOL 1,2-PROPANDIOL DL-1,2-PROPANEDIOL DL-PROPYLENE GLYCOL PROPANE-1,2-DIOL (PROPYLENE GLYCOL) PROPANE-1-2-DIOL PROPANEDIOL,1,2-
57-55-6
0 - 4.3
DODECYL SODIUM SULFATE
DODECYL SULFATE, SODIUM SALT SODIUM LAURYL SULPHATE LAURYL SULFATE SODIUM SALT
151-21-3
0-2
Unassigned
0-2
9004-82-4
0 - 2.0
NOVILLE FLAVOR AN133977 SODIUM LAURETH SULFATE
ALPHA-SULFO-OMEGA-(DODECYLOXY) POLY(OXY-1,2-ETHANEDIYL), SODIUM SALT GLYCOLS, POLYETHYLENE, MONO (HYDROGEN SULFATE), DODECYL ETHER, SODIUM SALT LAURETH SULPHATE SODIUM LAURYL ETHER SULFATE SODIUM SULFATE LAURYL ETHER SODIUM LAURETH SULPHATE
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
SDS CANADA
Issue date: 15-July-2016
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Chemical name
Common name and synonyms
CAS number
%
Titanium dioxide
TITANIUM OXIDE TITANIUM(IV) OXIDE TITANIUM PEROXIDE (TiO2) PIGMENT WHITE 6
13463-67-7
0-2
XANTHAN GUM
ACTIGUM CX 9 BIOPOLYMER XB-23 XANTHAN GUM BIOZAN R ENORFLO X FLOCON 1035 GALAXY XB KELFLO KELTROL (GUM) KELZAN KENTROL POLYSACCHARIDE B 1459 RHODOPOL 23 XANFLOOD XANTHOMONAS GUM
11138-66-2
2000 mg/kg
Rat
4400 mg/kg
Rat
3300 mg/kg
Rat
2426 mg/kg
Mouse
17 g/kg
GLYCERIN (CAS 56-81-5) Acute Oral LD50 Limonene (CAS 138-86-3) Acute Oral LD50 L-MENTHOL (CAS 2216-51-5) Acute Oral LD50 PEPPERMINT OIL (CAS 8006-90-4) Acute Oral LD50 SACCHARIN (CAS 81-07-2) Acute Oral LD50
SODIUM HYDROXIDE (CAS 1310-73-2) Acute Dermal LD50
Rabbit
1350 mg/kg
Oral LD50
Rat
104 - 340 mg/kg
SODIUM LAURETH SULFATE (CAS 9004-82-4) Acute Oral LD50
Rat
1288 mg/kg
SODIUM TRIPOLYPHOSPHATE (CAS 7758-29-4) Acute Oral LD50
Rat
3120 mg/kg
Inhalation LC50
Rat
6820 mcg/m3
Oral LD50
Rat
> 24 g/kg
Titanium dioxide (CAS 13463-67-7) Acute
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
SDS CANADA
Issue date: 15-July-2016
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Components
Species
Test results
Inhalation LOEC
Rat
8.6 mg/m3, 1 years TiO2 accumulated in interstitial macrophages, aggregated interstitial cells and particle laden macrophrages in lymphoid tissue.
NOAEC
Rat
250 mg/m3, 2 years Highest dose
Chronic
5 mg/m3, 24 months Subacute Inhalation LOEL
Rat
0.1 - 35 mg/m3, 4 weeks Mild macrophage hyperplasia, no change in bronchio-alveolar lavage fluid.
NOAEC
Guinea pig
26 mg/m3, 3 weeks No evidence of significant inflammation in respiratory tract.
Oral NOAEL
Rat
100000 ppm, 14 Day Dietary study, highest dose tested.
Rat
3.2 - 20 mg/m3, 8 min Accumulation of TiO2 in macrophages and evidence of pulmonary inflammation.
Inhalation LC50
Rat
> 21 mg/l, 1 hour exposure
Oral LD50
Rat
> 5000 mg/kg
Rat
350 mg/kg
Subchronic Inhalation LOEC
XANTHAN GUM (CAS 11138-66-2) Acute
Zinc chloride (CAS 7646-85-7) Acute Oral LD50
* Estimates for product may be based on additional component data not shown. Causes mild skin irritation.
Skin corrosion/irritation
Corrosivity SODIUM HYDROXIDE
Literature search Result: Causes severe burns. Literature search Result: Positive
PEPPERMINT OIL Irritation Corrosion - Skin Titanium dioxide
0, Literature data Result: Non-irritant Species: Guinea pig 0, Literature data Result: Non-irritant Species: Human Acute dermal irritation; OECD 404, Literature data Result: Non-irritant Species: Rabbit
Irritation Corrosion - Skin: P.I.I. value SACCHARIN
Serious eye damage/eye irritation
OECD 404, Data for sodium saccharin Result: Mild irritation Species: Rabbit Direct contact with eyes may cause temporary irritation. May be irritating to eyes.
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
SDS CANADA
Issue date: 15-July-2016
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Eye SODIUM HYDROXIDE
Literature search Result: Causes severe burns. Literature search Result: Mild/moderate Irritant OECD 405, Data for sodium saccharin. Result: Moderate Irritant Species: Rabbit OECD 405, Literature data Result: Mild irritant Species: Rabbit
PEPPERMINT OIL SACCHARIN
Titanium dioxide
Respiratory or skin sensitisation Canada - Alberta OELs: Irritant Calcium carbonate (CAS 471-34-1) GLYCERIN (CAS 56-81-5) SODIUM HYDROXIDE (CAS 1310-73-2) Titanium dioxide (CAS 13463-67-7) Zinc chloride (CAS 7646-85-7)
Irritant Irritant Irritant Irritant Irritant
Respiratory sensitisation
Not available.
Skin sensitisation
May cause an allergic skin reaction.
Sensitisation Titanium dioxide
Limonene PEPPERMINT OIL Titanium dioxide
Germ cell mutagenicity
5 % Optimisation Test, Literature data - Vehicle: petrolatum Result: negative Species: Guinea pig Test Duration: 48 hour exposure Literature search Result: Positive Literature search Result: Positive Patch test, Literature data Result: negative Species: Human No data available to indicate product or any components present at greater than 0.1% are mutagenic or genotoxic.
Mutagenicity Titanium dioxide
Carcinogenicity
Titanium dioxide
Ames, Literature data Result: negative Micronucleus Assay in vitro, CHO cells, Literature data Result: negative Micronucleus Assay in vitro, cultured human peripheral lymphocytes, Literature data Result: Positive Syrian Hamster Embryo (SHE) cell transformation assay Result: negative WIL2-NS HPRT/ t-Thioguanidine - Human B-Cell lymphoblastoid, Literature data Result: Positive Risk of cancer cannot be excluded with prolonged exposure. Health injuries are not known or expected under normal use. Titanium Dioxide produced carcinogenic effects in a lifetime study in mice High concentrations or doses administered over an extended period of time were required to produce adverse effects. 0.5 mg/m3, Literature data Result: negative Species: Rat Test Duration: 24 months 0.72 - 14.8 mg/m3, Literature data Result: negative Species: Mouse 10 - 250 mg/m3, Dietary study - Literature data. Result: Inflammation at all doses with alveolar/bronchiolar adenoma at the highest concentration. Species: Rat Test Duration: 24 months
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
SDS CANADA
Issue date: 15-July-2016
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Carcinogenicity Titanium dioxide
25000 - 50000 ppm, Dietary study Result: negative Species: Mouse 25000 - 50000 ppm, Dietary study - Literature data. Result: negative Species: Rat 7.2 - 14.8 mg/m3, Literature data Result: Lung tumour Species: Rat Test Duration: 24 months
ACGIH Carcinogens Quartz (CAS 14808-60-7) A2 Suspected human carcinogen. Sodium fluoride (CAS 7681-49-4) A4 Not classifiable as a human carcinogen. Titanium dioxide (CAS 13463-67-7) A4 Not classifiable as a human carcinogen. Canada - Alberta OELs: Carcinogen category Quartz (CAS 14808-60-7) Suspected human carcinogen. Canada - Manitoba OELs: carcinogenicity FLUORIDES, AS F (CAS 7681-49-4) Not classifiable as a human carcinogen. SILICA, CRYSTALLINE-.ALPHA.-QUARTZ, Suspected human carcinogen. RESPIRABLE FRACTION (CAS 14808-60-7) Titanium dioxide (CAS 13463-67-7) Not classifiable as a human carcinogen. Canada - Quebec OELs: Carcinogen category Quartz (CAS 14808-60-7) Suspected carcinogenic effect in humans. IARC Monographs. Overall Evaluation of Carcinogenicity Quartz (CAS 14808-60-7) 1 Carcinogenic to humans. SACCHARIN (CAS 81-07-2) 3 Not classifiable as to carcinogenicity to humans. SIDENT (CAS 7631-86-9) 3 Not classifiable as to carcinogenicity to humans. SILICA, AMORPHOUS HYDRATED (CAS 10279-57-9) 3 Not classifiable as to carcinogenicity to humans. Silicon dioxide (CAS 7631-86-9) 3 Not classifiable as to carcinogenicity to humans. Sodium fluoride (CAS 7681-49-4) 3 Not classifiable as to carcinogenicity to humans. Titanium dioxide (CAS 13463-67-7) 2B Possibly carcinogenic to humans. TIXOSIL (CAS Unassigned) 3 Not classifiable as to carcinogenicity to humans. ZEODENT 124 (CAS 7631-86-9) 3 Not classifiable as to carcinogenicity to humans. US. National Toxicology Program (NTP) Report on Carcinogens Quartz (CAS 14808-60-7) Known To Be Human Carcinogen. This product is not expected to cause reproductive or developmental effects. Reproductive toxicity Specific target organ toxicity - single exposure
None known.
Specific target organ toxicity - repeated exposure
None known.
Aspiration hazard
Not available.
Chronic effects
Not expected to be hazardous by WHMIS criteria.
Further information
None known.
12. Ecological information Ecotoxicity
Harmful to aquatic life with long lasting effects. Contains a substance which causes risk of hazardous effects to the environment.
Components
Species
Test results
Calcium carbonate (CAS 471-34-1) Aquatic Fish
LC50
Western mosquitofish (Gambusia affinis) > 56000 mg/l, 24 hours
CETYLPYRIDINIUM CHLORIDE (CAS 123-03-5) Aquatic Acute Activated Sludge Respiration Crustacea
IC50
Residential sludge
20 mg/l
EC50
Water flea (Daphnia magna)
0.0014 mg/l, 48 hours Static test
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
SDS CANADA
Issue date: 15-July-2016
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Components NOEC
Species
Test results
Water flea (Daphnia magna)
0.0006 mg/l, 48 hours Static test
COCOAMIDOPROPYL BETAINE (CAS 61789-40-0) Aquatic Acute Algae
EC50
Green algae (Scenedesmus subspicatus)
0.55 mg/l, 96 hours
NOEC
Green algae (Scenedesmus subspicatus)
0.09 mg/l, 96 hours
EC50
Water flea (Daphnia magna)
6.5 mg/l, 48 hours
NOEC
Water flea (Daphnia magna)
1.6 mg/l, 48 hours
EC50
Zebra fish (Adult Brachydanio rerio)
2 mg/l, 96 hours semi-static test conditions
NOEC
Zebra fish (Adult Brachydanio rerio)
1.7 mg/l, 96 hours semi-static test conditions
Microtox
MIC
Pseudomonas
> 3000 mg/l, 16 hours
Chronic Crustacea
LOEC
Water flea (Daphnia magna)
3.6 mg/l, 21 days
NOEC
Water flea (Daphnia magna)
0.9 mg/l, 21 days
Crustacea Fish
DODECYL SODIUM SULFATE (CAS 151-21-3) Aquatic Acute Crustacea
EC50
Water flea (Daphnia magna)
5.4 mg/l, 48 hours Static test
Fish
EC50
Rainbow trout (Adult Oncorhyncus mykiss)
4.6 mg/l, 96 hours Flow-through test
Chronic Algae
NOEC
Green algae (Desmodesmus subspicatus)
30 mg/l, 72 hours
Crustacea
NOEC
Ceriodaphnia dubia
0.88 mg/l, 7 days Flow-though Test
Fish
NOEC
Fathead minnow (Pimephales promelas) 3.8 mg/l, 28 days Flow-through test
Limonene (CAS 138-86-3) Aquatic Acute Algae
NOEC
Algae
> 4.08 mg/l, 96 hours Static test
Crustacea
EC50
Water flea (Daphnia magna)
28.2 mg/l, 48 hours Flow-through test
Fish
EC50
Fathead minnow (Adult Pimephales promelas)
38.5 mg/l, 96 hours Flow-through test
Golden ide/orfe (Adult Leuciscus idus)
32 mg/l, 48 hours
L-MENTHOL (CAS 2216-51-5) Aquatic Acute Algae
EC50
Green algae (Desmodesmus subspicatus)
21.4 mg/l, 72 hours OECD 201
Crustacea
EC50
Water flea (Daphnia magna)
37.7 mg/l, 24 hours OECD 202
Fish
LC50
Zebra danio (Danio rerio)
15.6 mg/l, 96 hours EU Method C.1
Chronic Algae
NOEC
Green algae (Desmodesmus subspicatus)
9.65 mg/l, 72 hours OECD 201
Water flea (Daphnia magna)
490 mg/l, 48 hours Static test
Potassium nitrate (CAS 7757-79-1) Aquatic Acute Crustacea
EC50
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
SDS CANADA
Issue date: 15-July-2016
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Components
Species
Test results
Bluegill sunfish (Adult Lepomis macrochirus)
420 mg/l, 96 hours Static test
Guppy (Juvenile Poecilia reticulata)
180 mg/l, 96 hours Static test
Mosquito fish (Adult Gambusia affinis)
22.5 mg/l, 96 hours Static test
Activated sludge
> 1000 mg/l, 3 hours
EC50
Green algae (Selenastrum capricornutum)
19000 mg/l, 14 days
NOEC
Green algae (Selenastrum capricornutum)
15000 mg/l, 14 days
EC50
Daphnia
43500 mg/l, 48 hours
NOEC
Daphnia
28500 mg/l, 48 hours
EC50
Fathead minnow (Adult Pimephales promelas)
51400 mg/l, 96 hours Static test
Rainbow trout (Adult Oncorhyncus mykiss)
51600 mg/l, 96 hours Static test
Fathead minnow (Adult Pimephales promelas)
41000 mg/l, 96 hours Static test
Rainbow trout (Adult Oncorhyncus mykiss)
42000 mg/l, 96 hours Static test
EC50
Microtox
51400 mg/l, 30 minutes
EC50
Fathead minnow (Adult Pimephales promelas)
15000 mg/l, 96 hours
Aquatic Acute Crustacea
NOEC
Water flea (Daphnia magna)
> 10000 mg/l, 24 hours
Fish
NOEC
Zebra fish (Adult Brachydanio rerio)
> 10000 mg/l, 96 hours
EC50
Green algae (Selenastrum capricornutum)
440 mg/l, 72 hours
NOEC
Green algae (Selenastrum capricornutum)
60 mg/l, 72 hours
Crustacea
EC50
Water flea (Daphnia magna)
> 10000 mg/l, 24 hours Static test
Fish
EC50
Common carp (Juvenile Cyprinus carpio) > 10000 mg/l, 72 hours
Fish
EC50
Propylene glycol (CAS 57-55-6) Acute IC50 Aquatic Acute Algae
Crustacea Fish
NOEC
Microtox SACCHARIN (CAS 81-07-2) Aquatic Acute Fish SIDENT (CAS 7631-86-9)
Silicon dioxide (CAS 7631-86-9) Aquatic Acute Algae
Microtox
EC50
Sodium fluoride (CAS 7681-49-4) Acute IC50 Aquatic Acute Algae
EC50
Zebra fish (Adult Brachydanio rerio)
5000 mg/l, 96 hours Static test
Microtox
8700 mg/l, 15 minutes
Activated sludge
2930 mg/l, 3 hours
Green algae (Selenastrum capricornutum)
272 mg/l, 96 hours
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
SDS CANADA
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Components
Species
Test results
Crustacea
EC50
Water flea (Daphnia magna)
340 mg/l, 48 hours Static test
Fish
EC50
Fathead minnow (Juvenile Pimephales promelas)
180 mg/l, 96 hours Static renewal test
Mosquito fish (Adult Gambusia affinis)
418 mg/l, 96 hours Static test
Rainbow trout (Juvenile Oncorhyncus mykiss)
108 mg/l, 96 hours Static test
Mosquito fish (Adult Gambusia affinis)
125 mg/l, 96 hours Static test
Rainbow trout (Adult Oncorhyncus mykiss)
45.4 mg/l, 96 hours Static test
SODIUM HYDROXIDE (CAS 1310-73-2) Aquatic Acute Fish
EC50
SODIUM LAURETH SULFATE (CAS 9004-82-4) Aquatic Acute Crustacea
EC50
Water flea (Ceriodaphnia dubia)
SODIUM TRIPOLYPHOSPHATE (CAS 7758-29-4) Acute IC50 Activated sludge
3.12 mg/l, 48 hours
> 1000 mg/l, 3 hours
Aquatic Acute Algae
EC50
Algae
60 - 120 mg/l
Crustacea
EC50
Water flea (Daphnia magna)
1089 mg/l, 50 hours
Fish
EC50
Golden ide/orfe (Adult Leuciscus idus)
1650 mg/l, 48 hours
Orange-red killfish (Adult Oryzias latipes)
590 mg/l, 48 hours Static test
Titanium dioxide (CAS 13463-67-7) Aquatic Fish
LC50
Mummichog (Fundulus heteroclitus)
> 1000 mg/l, 96 hours
Acute Crustacea
EC50
Water flea (Daphnia magna)
> 1000 mg/l, 48 hours Static test
Rainbow trout (Adult Oncorhyncus mykiss)
420 mg/l, 96 hours Static test
Activated sludge
30 mg/l
XANTHAN GUM (CAS 11138-66-2) Aquatic Acute Fish
EC50
Zinc chloride (CAS 7646-85-7) Acute IC50 Aquatic Acute Algae
EC50
Green algae (Selenastrum capricornutum)
136 µg/l, 72 hours OECD 201
Crustacea
EC50
Water flea (Ceriodaphnia dubia)
169 µg/l, 48 hours
Fish
EC50
Bluegill sunfish (Adult Lepomis macrochirus)
2.86 - 3.78 mg/l, 96 hours
Fathead minnow (Adult Pimephales promelas)
0.55 mg/l, 96 hours
Guppy (Juvenile Poecilia reticulata)
3.25 mg/l, 96 hours
Rainbow trout (Adult Oncorhyncus mykiss)
0.066 mg/l, 96 hours
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
SDS CANADA
Issue date: 15-July-2016
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Components Chronic Algae
NOEC
Species
Test results
Green algae (Pseudokirchnereilla subcapitata)
24 µg/l, 3 days OECD 201
* Estimates for product may be based on additional component data not shown. Persistence and degradability Photolysis Half-life (Photolysis-aqueous) Propylene glycol Half-life (Photolysis-atmospheric) L-MENTHOL Limonene Propylene glycol SACCHARIN
1.3 - 2.3 years Estimated 16 Hours Estimated < 3 Hours Estimated 32 Hours Estimated 3 Days Estimated
Biodegradability Percent degradation (Aerobic biodegradation-inherent) COCOAMIDOPROPYL BETAINE 97 %, 28 days Modified Zahn-Wellens, DOC removal., Activated sludge 99 %, 28 days Modified Zahn-Wellens, DOC removal., Activated sludge Propylene glycol 62 %, 5 days BOD5, Activated sludge 79 %, 20 Days BOD20, Activated sludge Percent degradation (Aerobic biodegradation-ready) COCOAMIDOPROPYL BETAINE 100 %, 20 Days Modified Sturm test., Activated sludge 84 %, 30 days Closed Bottle test, Activated sludge DODECYL SODIUM SULFATE 95 % OECD 301 B L-MENTHOL 0 %, 28 days Limonene 41 - 98 %, 14 days Modified MITI test, Activated sludge > 93.8 %, 14 days Coupled Unit test (OECD 303A), Activated sludge SODIUM LAURETH SULFATE 100 % River die away, River water Bioaccumulative potential Partition coefficient n-octanol / water (log Kow) CETYLPYRIDINIUM CHLORIDE DODECYL SODIUM SULFATE GLYCERIN L-MENTHOL Limonene Propylene glycol SACCHARIN SODIUM LAURETH SULFATE Bioconcentration factor (BCF) CETYLPYRIDINIUM CHLORIDE L-MENTHOL Limonene Propylene glycol SACCHARIN Sodium fluoride Zinc chloride
1.71 1.6 -1.76 3.3 4.232 -1.35 0.91 1.99 (calculated) 2 Estimated 1 - 15 Measured, Cyprinus carpio, carp 246 - 262 Calculated < 1 Estimated 3 Estimated 2.3 Measured > 1000 Measured
Mobility in soil Adsorption Soil/sediment sorption - log Koc CETYLPYRIDINIUM CHLORIDE L-MENTHOL Limonene SACCHARIN
2.3 Estimated 3.18 Estimated 3.01 - 3.68 Estimated 1.88 Estimated
Mobility in general Volatility Henry's law L-MENTHOL Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
0.000015 atm m^3/mol Estimated SDS CANADA
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Volatility Henry's law Limonene Propylene glycol SACCHARIN Other adverse effects
0.0319 atm m^3/mol, 25 C Estimated 0 atm m^3/mol Estimated 0 atm m^3/mol Estimated None known.
13. Disposal considerations Disposal instructions
Dispose of contents/container in accordance with local/regional/national/international regulations.
Local disposal regulations
Dispose in accordance with all applicable regulations.
Hazardous waste code
The waste code should be assigned in discussion between the user, the producer and the waste disposal company. Dispose of in accordance with local regulations. Empty containers or liners may retain some product residues. This material and its container must be disposed of in a safe manner (see: Disposal instructions). Avoid discharge into water courses or onto the ground. Since emptied containers may retain product residue, follow label warnings even after container is emptied.
Waste from residues / unused products Contaminated packaging
14. Transport information IATA Not regulated as dangerous goods. IMDG Not regulated as dangerous goods. Not available. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
15. Regulatory information Canadian regulations Controlled Drugs and Substances Act Not regulated. Export Control List (CEPA 1999, Schedule 3) Not listed. Greenhouse Gases Not listed. Precursor Control Regulations Not regulated. The product is classified and labelled in accordance with EC directives or respective national laws. International regulations This Safety Data Sheet complies with the requirements of Regulation (EC) No 1907/2006. Stockholm Convention Not applicable. Rotterdam Convention Not applicable. Kyoto protocol Not applicable. Montreal Protocol Not applicable. Basel Convention Not applicable. International Inventories Country(s) or region Australia
Inventory name Australian Inventory of Chemical Substances (AICS)
Canada
Domestic Substances List (DSL)
No
Canada
Non-Domestic Substances List (NDSL)
No
China
Inventory of Existing Chemical Substances in China (IECSC)
No
Europe
European Inventory of Existing Commercial Chemical Substances (EINECS)
No
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
On inventory (yes/no)* No
SDS CANADA
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Country(s) or region Europe
Inventory name European List of Notified Chemical Substances (ELINCS)
On inventory (yes/no)* No
Japan
Inventory of Existing and New Chemical Substances (ENCS)
No
Korea
Existing Chemicals List (ECL)
No
New Zealand
New Zealand Inventory
No
Philippines
Philippine Inventory of Chemicals and Chemical Substances (PICCS)
No
United States & Puerto Rico
Toxic Substances Control Act (TSCA) Inventory
No
*A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s) A "No" indicates that one or more components of the product are not listed or exempt from listing on the inventory administered by the governing country(s).
16. Other information Issue date
15-July-2016
Revision date
17-January-2017
Version No.
55
References
ACGIH EPA: AQUIRE database NLM: Hazardous Substances Data Base US. IARC Monographs on Occupational Exposures to Chemical Agents HSDB® - Hazardous Substances Data Bank IARC Monographs. Overall Evaluation of Carcinogenicity National Toxicology Program (NTP) Report on Carcinogens ACGIH Documentation of the Threshold Limit Values and Biological Exposure Indices Japan Society for Occupational Health, Recommendation of Occupational Exposure Limits GSK Hazard Determination GOST 30333-2007 - Chemical production safety passport. General requirements JIS Z 7252:2009 Classification of chemicals based on ”Globally Harmonized System of Classification and Labelling of Chemicals (GHS)” JIS Z 7253:2012 Hazard communication of chemicals based on GHS – Labelling and Safety Data Sheet (SDS) Japan Chemical Industry Association (JCIA) GHS Guideline, June 2012 The information and recommendations in this safety data sheet are, to the best of our knowledge, accurate as of the date of issue. Nothing herein shall be deemed to create any warranty, express or implied. It is the responsibility of the user to determine the applicability of this information and the suitability of the material or product for any particular purpose. Composition / Information on Ingredients: Ingredients
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Revision information
Material name: AQUAFRESH TOOTHPASTE 135408 Version #: 55 Revision date: 17-January-2017
SDS CANADA
Issue date: 15-July-2016
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