Julius Brennecke
Curriculum Vitae PERSONAL DATA Name:
Julius Fabian Brennecke
Country of Citizenship:
Germany
Date and Place of Birth:
26. 09. 75 in Munich, Germany
Email:
[email protected]
Work Address:
Institut für Molekulare Biotechnologie GmbH Dr. Bohrgasse 3 1030 Vienna, Austria http://www.imba.oeaw.ac.at/research/julius-brennecke/
Webpage:
PROFESSIONAL EMPLOYMENT since 2014
senior investigator at the IMBA, Vienna, Austria
2009 - 2013
independent group leader at the IMBA, Vienna, Austria
2006 - 2008
postdoctoral studies with Prof. Gregory Hannon at Cold Spring Harbor Laboratories, USA
2005 - 2006
postdoctoral studies with Dr. Stephen Cohen, EMBL Heidelberg, Germany
EDUCATION 2004
PhD degree (summa cum laude) EMBL Heidelberg and Ruprecht-Karls University Heidelberg; 07/2004
2001 - 2004
PhD thesis under supervision of Dr. Stephen M. Cohen at the EMBL Heidelberg; title: “microRNAs in Drosophila – The bantam microRNA Regulates Growth and Computational Identification of microRNA targets
2000 - 2001
Continuation of Diploma Thesis Project with Dr. D. Bohmann (University of Rochester, NY, USA)
2000
Diploma degree (1.0) in Molecular Biology, Cell Biology and Botany at the Ruprecht-Karls University Heidelberg; 03/27/2001
2000
Diploma Thesis under supervision of Dr. D. Bohmann at the EMBL Heidelberg: title: “A Method to Study Protein-Protein Interactions in
Julius Brennecke
Drosophila Using Tandem Affinity Spectrometric Peptide Sequencing”
Chromatography
and
Mass
1995 - 2000
studies in Biology at the Ruprecht-Karls University Heidelberg, Germany
1994
Abitur (high school degree; 1.4)
Julius Brennecke
FIELD RESEARCH IN CONSERVATION BIOLOGY 09/2004 - 02/2005
field assistant in the Galapagos Islands with Prof. Dave Anderson (Wake Forest University, USA) on the endemic Galapagos Albatros population.
06/1999 - 09/1999
field assistant in the Serengeti, Tanzania with Dr. H. Hoeck (Max Planck Institute Seewiesen, Germany) on population genetics of Hyrax species.
10/1997 - 03/1998
field assistant in the Galapagos Islands with Prof. Dave Anderson (Wake Forest University, USA) on evolutionary dynamics of seabird populations.
HONORS AND AWARDS 2012
Förderpreis der Stadt Wien
2011
Member of the Junge Kurie of the Austrian Academy of Sciences
2010
ERC Starting Grant from the European Union
2010
START Prize (FWF Austria)
2010
‚Premio Leonardo Prize’ of ten European Rotary Clubs (Vienna)
2009
John Kendrew Award (EMBL Heidelberg)
2007 - 2008
Postdoctoral fellowship from the Ernst Schering Foundation, Berlin
CAREER RELATED ACTIVITIES •
32 publications listed in PubMed (>5000 citations; h-index 22)
•
ad hoc reviewer for Cell, Science, Nature, Developmental Cell, Cell Stem Cell, Current Biology, Molecular Cell, Nature Cell Biology, Nature Structural and Molecular Biology, PNAS, EMBO Journal, Silence;
•
Co-organizer for “Microsymposium on small RNAs” 2010/2011/2013/2014, Vienna (Austria)
•
Co-organizer for Keystone Symposium “RNA Silencing” 2014, Seattle (USA)
FUNDING ID •
RNA Doktoratskolleg; FWF, Austria (2014)
•
START Award from the FWF, Austria (2010)
•
SFB Grant (RNA regulation) from the FWF, Austria (2010)
•
ERC Starting Grant from the European Research Council (2010)
Julius Brennecke
PUBLICATIONS A.) as independent investigator at IMBA: Drosophila Gtsf1 is an essential component of the Piwi mediated transcriptional silencing complex Dönertas D, Sienski G, Brennecke J. Genes Dev. 2013 Aug 1;27(15):1693-705. The Genetic Makeup of the Drosophila piRNA Pathway. Handler D, Meixner K, Pizka M, Lauss K, Schmied C, Gruber FS, Brennecke J. Mol Cell. 2013 Jun 6;50(5):762-77. Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. Sienski G, Dönertas D, Brennecke J. Cell. 2012 Nov 21;151(5):964-80. The cochaperone Shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Olivieri D, Senti KA, Subramanian S, Sachidanandam R, Brennecke J. Mol Cell. 2012 Sep 28;47(6):954-69 A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. Handler D, Olivieri D, Novatchkova M, Gruber FS, Meixner K, Mechtler K, Stark A, Sachidanandam R, Brennecke J. EMBO J. 2011 Aug 23;30(19):3977-93. A genome-scale shRNA resource for transgenic RNAi in Drosophila. Ni JQ, Zhou R, Czech B, Liu LP, Holderbaum L, Yang-Zhou D, Shim HS, Tao R, Handler D, Karpowicz P, Binari R, Booker M, Brennecke J, Perkins LA, Hannon GJ, Perrimon N. Nat Methods. 2011 May;8(5):405-7. The piRNA pathway: a fly's perspective on the guardian of the genome. Senti KA, Brennecke J. Trends Genet. 2010 Dec;26(12):499-509. Review. An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. Olivieri D, Sykora MM, Sachidanandam R, Mechtler K, Brennecke J. EMBO J. 2010 Oct 6;29(19):3301-17. B.) from postdoctoral work: Preparation of small RNA libraries for high-throughput sequencing. Malone C, Brennecke J, Czech B, Aravin A, Hannon GJ. Cold Spring Harb Protoc. 2012 Oct 1;2012(10):1067-77.
Julius Brennecke
Hierarchical rules for Argonaute loading in Drosophila. Czech B, Zhou R, Erlich Y, Brennecke J, Binari R, Villalta C, Gordon A, Perrimon N, Hannon GJ. Mol Cell. 2009 Nov 13;36(3):445-56. Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. Zhou R, Czech B, Brennecke J, Sachidanandam R, Wohlschlegel JA, Perrimon N, Hannon GJ. RNA. 2009 Oct;15(10):1886-95. Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Malone CD, Brennecke J, Dus M, Stark A, McCombie WR, Sachidanandam R, Hannon GJ. *equal contribution: Malone and Brennecke Cell. 2009 May 1;137(3):522-35. An epigenetic role for maternally inherited piRNAs in transposon silencing. Brennecke J, Malone CD, Aravin AA, Sachidanandam R, Stark A, Hannon GJ. *equal contribution: Brennecke and Malone Science. 2008 Nov 28;322(5906):1387-92. An endogenous small interfering RNA pathway in Drosophila. Czech B, Malone CD, Zhou R, Stark A, Schlingeheyde C, Dus M, Perrimon N, Kellis M, Wohlschlegel JA, Sachidanandam R, Hannon GJ, Brennecke J. Nature. 2008 Jun 5;453(7196):798-802. Analysis of large-scale sequencing of small RNAs. Olson AJ, Brennecke J, Aravin AA, Hannon GJ, Sachidanandam R. Pac Symp Biocomput. 2008:126-36. A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. Stark A, Bushati N, Jan CH, Kheradpour P, Hodges E, Brennecke J, Bartel DP, Cohen SM, Kellis M. Genes Dev. 2008 Jan 1;22(1):8-13. Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M. Genome Res. 2007 Dec;17(12):1865-79. Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Stark A, Lin MF, Kheradpour P, Pedersen JS, Parts L, Carlson JW, Crosby MA, Rasmussen MD, Roy S, Deoras AN, Ruby JG, Brennecke J; Harvard FlyBase curators; Berkeley Drosophila Genome Project, Hodges E, Hinrichs AS, Caspi A, Paten B, Park SW, Han MV, Maeder ML, Polansky BJ, Robson BE, Aerts S, van Helden J, Hassan B, Gilbert DG, Eastman DA, Rice M, Weir M, Hahn MW, Park Y, Dewey CN, Pachter L, Kent WJ, Haussler D, Lai EC, Bartel DP, Hannon GJ, Kaufman TC, Eisen MB, Clark AG, Smith D, Celniker SE, Gelbart WM, Kellis M. Nature. 2007 Nov 8;450(7167):219-32. The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Aravin AA, Hannon GJ, Brennecke J. Science. 2007 Nov 2;318(5851):761-4. Review. Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Brennecke J, Aravin AA, Stark A, Dus M, Kellis M, Sachidanandam R, Hannon GJ. Cell. 2007 Mar 23;128(6):1089-103.
Julius Brennecke
B.) from PhD work: Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila. Bushati N, Stark A, Brennecke J, Cohen SM. Curr Biol. 2008 Apr 8;18(7):501-6. Denoising feedback loops by thresholding--a new role for microRNAs. Cohen SM, Brennecke J, Stark A. Genes Dev. 2006 Oct 15;20(20):2769-72. Perspective. Developmental biology. Mixed messages in early development. Cohen SM, Brennecke J. Science. 2006 Apr 7;312(5770):65-6. News&Views. Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Rehwinkel J, Natalin P, Stark A, Brennecke J, Cohen SM, Izaurralde E. Mol Cell Biol. 2006 Apr;26(8):2965-75. Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Stark A, Brennecke J, Bushati N, Russell RB, Cohen SM. *equal contribution: Stark and Brennecke Cell. 2005 Dec 16;123(6):1133-46. Not miR-ly muscular: microRNAs and muscle development. Brennecke J, Stark A, Cohen SM. Genes Dev. 2005 Oct 1;19(19):2261-4. Perspective. Principles of microRNA-target recognition. Brennecke J, Stark A, Russell RB, Cohen SM. equal contribution: Brennecke and Stark PLoS Biol. 2005 Mar;3(3):e85. Identification of Drosophila MicroRNA targets. Stark A, Brennecke J, Russell RB, Cohen SM. *equal contribution: Stark and Brennecke PLoS Biol. 2003 Dec;1(3):E60. Towards a complete description of the microRNA complement of animal genomes. Brennecke J, Cohen SM. Genome Biol. 2003;4(9):228. Perspective. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM. Cell. 2003 Apr 4;113(1):25-36. From University education Perinatal androgens and adult behavior vary with nestling social system in siblicidal boobies. Müller MS, Brennecke JF, Porter ET, Ottinger MA, Anderson DJ. PLoS One. 2008 Jun 18;3(6):e2460.
Julius Brennecke
Transportin2 functions as importin and mediates nuclear import of HuR. Güttinger S, Mühlhäusser P, Koller-Eichhorn R, Brennecke J, Kutay U. Proc Natl Acad Sci USA. 2004 Mar 2;101(9):2918-23. Transrepression of AP-1 by nuclear receptors in Drosophila. Gritzan U, Weiss C, Brennecke J, Bohmann D. Mech Dev. 2002 Jul;115(1-2):91-100.
