Immune Support

R E I N F O R C E T H E B O DY ’S N AT U R A L D E F E N S E S

Quality dietary supplements • Research-driven probiotics • Homeopathic preparations

Reinforce the body’s natural defenses With the arrival of fall and the winter to follow, we must take particular care to sustain our optimal nutritional status. Maintaining vitamin D levels may help to support proper immune function, while supplementing with vitamin C and zinc helps to promote immune response. In addition, probiotic supplementation has been associated with healthy respiratory function. Seroyal provides vitamins, minerals, probiotics and herbal formulations in a variety of formats. We also offer homeopathic products to address some of the most common concerns specific to the colder seasons.†* Seroyal is a natural pharmaceutical company that has been dedicated for 30 years to assisting healthcare practitioners restore, rebuild and maintain patients’ health. Seroyal’s GENESTRA BRANDS, UNDA and Pharmax diverse product lines comprise your key source of effective dietary supplements and homeopathic remedies.

112 Technology Drive, Pittsburgh, PA 15275 TEL: 1-888-737-6925 | FAX: 1-877-737-6925 | EMAIL: [email protected] | WEBSITE: www.seroyal.com The aim of this comprehensive product guide is to assist in building more effective and successful patient treatment strategies. The remedies indicated in this product guide are potent medicines that can have profound therapeutic effects on patients. As with any intervention, the dosage may need to be adjusted for those with chronic conditions, very sensitive individuals and those taking multiple medications. Practitioners are solely responsible for the care and treatment provided to their own patients. The information provided by the speaker or speakers in the Seroyal Continuing Medical Education program together with any written material provided do not necessarily represent the views of Seroyal and are not intended as medical advice or an endorsement of any products. This information is for practitioner use only and is not meant to diagnose, treat, cure, prevent any disease or replace traditional treatment, and has not been evaluated by the FDA. * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. † Product ‘Uses’ are based on Homeopathic Materia Medica and have not been clinically tested. These ‘Uses’ have not been evaluated by the Food and Drug Administration. Copyright © 2015 Seroyal. All rights reserved. No part of this information may be used or reproduced in any form or by any means, or stored in a database or retrieval system, or be distributed or replicated without express permission of Seroyal. Making copies of any part of this information for any purposes other than your own personal use is a violation of copyright law.

2

1878. Version 8. 10/2015

Move over sick days. Hello HMF Fit for School.

SUPPLEMENT FACTS Serving Size 1 Tablet/ Servings per Container 30

GENESTRA BRANDS HMF Fit for School supports children’s upper respiratory tract health and immune function using a unique combination of research-driven probiotic strains and vitamin C. Each delicious blackcurrant flavored chewable tablet provides 12.5 billion CFU of proprietary strains, plus 50 mg of vitamin C – the same formulation shown to help maintain schoolchildren’s immune health in a recent clinical trial. HMF Fit for School also includes additional support for cellular immunity with 1000 IU of vitamin D per tablet.*

Each Tablet Contains Vitamin C (ascorbic acid) 50 mg 1000 IU Vitamin D3 (cholecalciferol) Probiotic Consortium 12.5 billion CFU Lactobacillus acidophilus (CUL-21) Lactobacillus acidophilus (CUL-60) Bifidobacterium animalis subsp. lactis (CUL-34) Bifidobacterium bifidum (CUL-20)

%DV 83% 250% t

t Daily Value (DV) not established Other ingredients: Xylitol, blackcurrant fruit extract, sorbitol, natural blackcurrant flavor, silica, magnesium stearate Recommended Dose: Adolescents and Children (4 years and older): Chew one tablet daily or as recommended by your healthcare practitioner. Product Size: 30 Chewable Tablets

Product Code: 10497

EGETARIAN

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Cor Defense

C1000

DIETARY SUPPLEMENT

VITAMIN SUPPLEMENT

Immune support formula* • Helps to maintain immune function* • Promotes normal nasal function and immune cell activity* • Provides 500 mg of bakers yeast (EpiCor®) per dose • Also includes zinc, the antioxidant vitamin C, and European elderberry flower extract

High-dose vitamin C and flavonoid combination • Supports immune function* • Promotes antioxidant support* • Promotes vitamin C intake* • Provides 1000 mg of vitamin C per tablet, plus rose hips, hesperidin, quercetin and rutin

Cor Defense contains EpiCor®, a proprietary and research-driven extract from Saccharomyces cerevisiae yeast designed to maintain immune function.1-3* Research demonstrates that daily supplementation with 500 mg of EpiCor® promotes mucosal immunity and regulates the infiltration of immune cells into the respiratory tract, which supports normal nasal function.1,4* Zinc further helps to maintain immune function by stimulating the production of lymphocytes and by increasing their phagocytic activity.5* Cor Defense also includes the antioxidant vitamin C and European elderberry flower extract for additional immune health support.6-8*

C1000 is a combination of vitamin C and a wide range of bioflavonoids that promotes immune health and antioxidant support.1-6* Vitamin C stimulates the immune system, resulting in increased T cell proliferation and neutrophil movement.2* Research demonstrates that intracellular vitamin C levels in leukocytes decrease naturally with age, which is associated with impaired neutrophil activity.2* However, supplementation with vitamin C in elderly adults may promote phagocytosis in neutrophils and improve antibody-mediated immune responses.3* Recent research suggests that smokers and elite athletes may experience the greatest benefit of vitamin C supplementation due to its potent antioxidant effects.1-2* As the body does not store vitamin C, continuous intake is required.2*

Supplement Facts Serving Size 1 Capsule/ Servings per Container 30 Each Tablet Contains Vitamin C (ascorbic acid) Vitamin D (cholecalciferol) Zinc (zinc monomethionine)

25 mg 50 IU 1 mg

Brewers Yeast (Saccharomyces cerevisiae) (EpiCor®t) European Elderberry (Sambucus nigra) Flower Extract (4:1) 300 mg Dried Equivalent

500 mg 75 mg

% DV 42% 13% 7% ♦ ♦

Supplement Facts Serving Size 1 Tablet/ Servings per Container 60 or 120 Each Tablet Contains Vitamin C (ascorbic acid)

% DV

1000 mg 1667%

Rose (Rosa canina) Hips

50 mg

♦

♦ Daily Value (DV) not established

Hesperidin (from Citrus aurantium pith/peel)

25 mg

♦

Other ingredients: Hypromellose, cellulose, magnesium stearate, silica

Quercetin

25 mg

♦

t EpiCor® is a registered trademark of Embria Health Sciences, L.L.C.

Rutin

25 mg

♦

♦ Daily Value (DV) not established

Recommended Dose Adults: Take one capsule daily with food, a few hours before or after taking other medications, or as recommended by your healthcare practitioner. 30 Capsules

Product Code: 04275 EGETARIAN

REFERENCES 1. Jensen, GS, Patterson, KM, Barnes, J, Schauss, AG, Beaman, R, Reeves, SG, Robinson, LE. The Open Nutrition Journal. 2008; 2: 68-75. 2. Moyad, MA, Robinson, LE, Zawada, ET Jr, Kittelsrud, JM, Chen, DG, Reeves, SG, Weaver, SE. Urol Nurs. 2008; 28(1): 50-55. 3. Moyad, MA Robinson, LE, Zawada, ET Jr, Kittelsrud, J, Chen, DG, Reeves, SG, Weaver, S. The Journal of Alternative and Complementary Medicine. 2010; 16(2): 213-218. 4. Moyad, MA, Robinson, LE, Kittelsrud, JM, Reeves, SG, Weaver, SE, Guzman, AI, Bubak, ME. Adv Ther. 2009; 26(8): 795-804. 5. Chasapis, CT, Spiliopoulou, CA, Loutsidou, AC, Stefanidou, ME. Arch Toxicol. 2012; 86: 521–534. 6. Kalra, M, Khatak, M, Khatak, S. International Journal of Drug Development & Research. 2011; 3(1): 314-327. 7. Gorton HC, Jarvis K. J Manipulative Physiol Ther. 1999 Oct;22(8):530-3. 8. Peters EM, Goetzsche JM, Grobbelaar B, Noakes TD. Am J Clin Nutr. 1993 Feb;57(2):170-4.

4

Other ingredients: Cellulose, silica, croscarmellose sodium, magnesium stearate, hypromellose, glycerin

Recommended Dose Adult Dose (19 years and older): Take one tablet two times daily with meals or as recommended by your healthcare practitioner.

Size

Product Code

60 Tablets 120 Tablets

01110 01110120

REFERENCES 1. Peters EM, Goetzsche JM, Grobbelaar B, Noakes TD Am J Clin Nutr. 1993 Feb;57(2):170-4. 2. Wintergerst, ES, Maggini, S, Hornig, DH. Ann Nutr Metab. 2006; 50: 85–94. 3. Jayachandran, M, Rani, PJA, Arivazhagan, P, Panneerselvam, C. (Abstract). Journal of Anti-Aging Medicine. 2000; 3(1): 37-42. 4. Alía, M, Mateos, R, Ramos, S, Lecumberri, E, Bravo, L, Goya, L. Eur J Nutr. 2006; 45 : 19–28. 5. Wilmsen, PK, Spada, DS, Salvador, M. J. Agric. Food Chem. 2005; 53: 4757-4761. 6. Gonzalez-Gallego, J, Garcia-Mediavilla, MV, Sanchez-Campos, S, Tunon, M. British Journal of Nutrition. 2010; 104: S15–S27.

D-Mulsion 400 and 1000

D3 400 and D3 1000 Drops

VITAMIN SUPPLEMENT

VITAMIN SUPPLEMENT

Emulsified vitamin D supplement • Supports immune health* • Promotes vitamin D intake* • Provides 400 or 1000 IU of vitamin D per drop • Great-tasting citrus and spearmint flavors (D-Mulsion 1000 only)

Vitamin D in a convenient liquid drop format • Supports immune health* • Promotes vitamin D intake* • Provides 400 or 1000 IU of vitamin D per drop D3 400 and 1000 Drops come in a convenient, easy-to-use liquid drop format – just one drop contains either 400 or 1000 IU of vitamin D. D3 400 and 1000 Drops can be dropped directly into the mouth or mixed into drinks, are good alternatives for individuals who have difficulty swallowing capsules, and are suitable for individuals of all ages. Recent research demonstrates that low vitamin D status is associated with decreased upper respiratory immune function.2,3 However, vitamin D supplementation has been shown to have beneficial effects on the function of a variety of immune cells, including dendritic cells, macrophages, and T cells.1* Research demonstrates that vitamin D mediates the proliferation of T and B cells, increases the phagocytic activity of macrophages, and promotes a healthy cytokine balance to promote normal immune function.4

D-Mulsion 400 and 1000 provide vitamin D using the proprietary WisdOM-3™ emulsification process for enhanced bioavailability and improved palatability. The vitamin D receptor is found on most immune cells, including T cells, B cells, and macrophages, demonstrating an important interaction between vitamin D and the immune system.1 Low vitamin D status has been associated with decreased upper respiratory immune function, while vitamin D supplementation has been shown to have beneficial effects on the function of a variety of immune cells.2-4 Research demonstrates that vitamin D mediates the proliferation of T and B cells, increases the phagocytic activity of macrophages, and promotes a healthy cytokine balance.5 D-Mulsion 400 and 1000 are good alternatives for individuals who have difficulty swallowing capsules and are suitable for individuals of all ages.*

D3 400 Drops

Supplement Facts

D-Mulsion 400

Serving Size 1 Drop (0.028 ml)/ Servings per Container about 1071

Supplement Facts

Each Capsule Contains

Serving Size 2 Drops (0.054 ml)/ Servings per Container about 555 Each Serving Contains Vitamin D (cholecalciferol) Stevia (Stevia rebaudiana) Leaf Std. Extract (95% glucosylsteviosides)

% DV

800 IU 200%

0.02 mg

♦

Vitamin D (cholecalciferol)

400 IU

% DV♦ 100%

♦ Daily Value (DV) Other ingredients: Medium chain triglycerides

Recommended Dose

♦ Daily Value (DV) not established

All ages: Take one drop daily or as recommended by your healthcare practitioner.

Other ingredients: Purified water, maltodextrin, modified tapioca starch, extra virgin olive oil, lemon oil, citric acid, potassium sorbate, natural mixed tocopherols

1fl oz (30 ml) Liquid

Product Code: 01173 EGETARIAN

Recommended Dose All Ages: Take two drops once daily or as recommended by your healthcare practitioner. 1 fl oz (30 ml) Liquid

D3 1000 Drops

Product Code: 01153

Supplement Facts Serving Size 1 Drop (0.028 ml)/ Servings per Container about 1071

EGETARIAN

Each Capsule Contains

D-Mulsion 1000 (Citrus)

Vitamin D (cholecalciferol)

Supplement Facts

♦ Daily Value (DV) not established

Serving Size 1 Drop (0.027 ml)/ Servings per Container about 1111 Each Drop Contains Vitamin D (cholecalciferol) Stevia (Stevia rebaudiana) Leaf Std. Extract (95% glucosylsteviosides)

% DV

1000 IU 250%

250%

Other ingredients: Medium chain triglycerides

Recommended Dose All ages: Take one drop daily or as recommended by your healthcare practitioner.



0.01 mg

♦ Daily Value (DV) not established

♦

1 fl oz (30 ml) Liquid

Product Code: 01152 EGETARIAN

Other ingredients: Purified water, maltodextrin, modified tapioca starch, extra virgin olive oil, lemon oil, citric acid, potassium sorbate, natural mixed tocopherols

Recommended Dose All Ages: Take one drop daily or as recommended by your healthcare practitioner. Citrus: 1 fl oz (30 ml) Liquid Spearmint: 1 fl oz (30 ml) Liquid

1000 IU

% DV♦

REFERENCES 1. Rolf L, Muris AH, Hupperts R, Damoiseaux J. Ann. N.Y. Acad. Sci. 2014; 1317: 84–91. 2. Bryson KJ, Nash AA, and Norval M. Epidemiology & Infection. 2014; 2(9): 1789-1801. 3. Sabetta J, DePetrillo P, Cipriani R, Smardin J, Burns A, and Landry M. PLoS One. 2010; 5(6): e11088. 4. Mora, JR, Iwata, M, von Andrian, UH. Nat Rev Immunol. 2008; 8(9): 685-698.

Product Code: 01154 Product Code: 01159

EGETARIAN

REFERENCES 1. Aranow, C. J Investig Med. 2011; 59(6): 881–886. 2. Bryson KJ, Nash AA, and Norval M. Epidemiology & Infection. 2014; 2(9): 1789-1801. 3. Sabetta J, DePetrillo P, Cipriani R, Smardin J, Burns A, and Landry M. PLoS One. 2010; 5(6): e11088. 4. Rolf L, Muris AH, Hupperts R, Damoiseaux J. Ann. N.Y. Acad. Sci. 2014; 1317: 84–91. 5. Mora, JR, Iwata, M, von Andrian, UH. Nat Rev Immunol. 2008; 8(9): 685-698.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

5

D3 1000

D3 1000 Chewable

VITAMIN SUPPLEMENT

VITAMIN SUPPLEMENT

Vitamin D in capsule format • Supports immune health* • Promotes vitamin D intake* • Provides 1000 IU of vitamin D per capsule

Chewable vitamin D supplement • Supports immune health* • Promotes vitamin D intake* • Provides 1000 IU of vitamin D per chewable tablet • Great-tasting natural blackcurrant flavor

D3 1000 provides 1000 IU of vitamin D in a vegetable capsule format. Very few products naturally contain relevant levels of vitamin D, and its synthesis in the skin can be altered by skin pigmentation, clothing, latitude, and sunscreen use.1 Vitamin D levels also vary depending on the season, with highest levels present during summer and lowest levels present during winter; this pattern also resembles the seasonal variation in immune system health.1 Low vitamin D status has been associated with decreased upper respiratory immune function, although vitamin D supplementation has been shown to have beneficial effects on the function of a variety of immune cells.2-4 In a recent controlled clinical trial involving children, daily supplementation with 1000 IU of vitamin D for 3 months was shown to significantly increase plasma vitamin D levels and promote a healthy cytokine balance. Following supplementation, levels of the cytokines IL-2, IL-4, IL-6, and IFN-γ were all significantly modified.5*

D3 1000 Chewable provides 1000 IU of vitamin D in a delicious natural blackcurrant flavored chewable tablet. Recent research has demonstrated an important interaction between vitamin D and the immune system.1* Vitamin D levels vary depending on the season, with highest levels present during summer and lowest levels present during winter; this pattern also resembles the seasonal variation in immune system health.2 Low vitamin D status has also been associated with decreased upper respiratory immune function, while vitamin D supplementation has been shown to have beneficial effects on the function of a variety of immune cells - including dendritic cells, macrophages, and T cells.3-5 In a recent controlled clinical trial involving children, daily supplementation with 1000 IU of vitamin D for 3 months was shown to significantly increase plasma vitamin D levels and promote a healthy cytokine balance.6 Following supplementation, levels of the cytokines IL-2, IL-4, IL-6, and IFN-γ were all significantly modified.6*

Supplement Facts Serving Size 1 Capsule/ Servings per Container 90

Supplement Facts

Each Capsule Contains Vitamin D (cholecalciferol)

1000 IU

% DV♦ 250%

Serving Size 1 Tablet/ Servings per Container 120 Each Tablet Contains

♦ Daily Value (DV)

Total Carbohydrate

Other ingredients: Hypromellose, cellulose, magnesium stearate

Vitamin D (cholecalciferol)

% DV .

0.09 ml

Size

Product Code

0.5 fl oz (15 ml) Liquid

23924

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Size

Product Code

0.5 fl oz (15 ml) Liquid

23935

UNDA Cold and Flu Homeopathic Preparations

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

13

Angiplex

Drosera Plex

HOMEOPATHIC PREPARATION

HOMEOPATHIC PREPARATION

Relief of sore throat symptoms† • Homeopathic preparation • Provides temporary relief of symptoms associated with sore throat† Angiplex provides a combination of synergistic homeopathic remedies specifically formulated to temporary relieve symptoms associated with sore throat, a common cause of physician visits and missed work.1 Symptoms of sore throat may include lower than normal pitch of the voice or hoarseness, which can last between three and eight days.1 Sore throat may also be associated with difficulty swallowing, the sensation of a foreign body in the throat, or cough.2 Each Angiplex tablet provides ingredients that help decrease burning and stinging in the throat, as well as weak, hoarse and croaking voice.†

Cough relief formula† • Homeopathic preparation • Provides temporary relief of coughs† Drosera Plex is a synergistic homeopathic preparation specifically formulated to assist with the temporary relief of coughs, one of the primary symptoms presented to physicians.1 While coughing is a normal defense mechanism that helps the body clear mucous or aspirated foreign particles, it can also be associated with wheezing, abnormal airways, difficulty eating, and impaired immune and respiratory function. Each drop of Drosera Plex contains ingredients that reduce coughing, including dry, short coughs.1 By specifically targeting the respiratory system, Drosera Plex helps promote and maintain overall respiratory health.†

EACH TABLET CONTAINS:

EACH DROP CONTAINS:

Aconitum napellus (Aconite) Whole Plant 8X. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Dry throat

Arnica montana (Leopard’s bane) Underground Parts 6X . . . . . . . . . . . . . . . . . . . . . . . Dry, short cough

Apis mellifica (Honey bee) 8X . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Difficulty swallowing

Belladonna (Deadly nightshade) Whole Plant 6X (. 2. Allan, GM, Arroll, B. CMAJ. 2014; 186(3): 190-199.

† Product ‘Uses’ are based on Homeopathic Materia Medica and have not been clinically tested. These ‘Uses’ have not been evaluated by the Food and Drug Administration.

Biotherapeutic Drainage™ Immune Support* Kit Biotherapeutic Drainage Immune Support* Kit contains a synergistic combination of UNDA Numbered Compound homeopathic products, plus GENESTRA BRANDS Imu-Gen for phytoembryotherapy support.* The kit includes UNDA Numbered Compounds 3 and 50 to strengthen and reinforce respiratory response against influenza, as well as UNDA Numbered Compound 20 to help reduce mucosal inflammation.†

Package includes: EACH DROP CONTAINS EQUAL PARTS OF: Equisetum arvense (Common horsetail) Stem 4X Chamomilla (German chamomile) Whole Flowering Plant 4X Condurango Bark 4X Viola tricolor (Pansy) Whole Plant 4X Boldo Leaf 4X Aluminium metallicum (Aluminum) 12X Stannum metallicum (Tin) 12X Other ingredients: Ethanol (beet), purified water

0.7 fl oz (20 ml) Liquid

NDC 62106-1102-8

Serving size 10 Drops (0.28 ml)/ Servings per Container about 53 EACH DROP (0.028 ml) CONTAINS: Sea Buckthorn (Hippophae rhamnoides) Bud Extract (1:20) 0.009 ml ♦ 4.7 mg Dried Equivalent English Walnut (Juglans regia) Bud Extract (1:20) 0.009 ml ♦ 4.7 mg Dried Equivalent Dog Rose (Rosa canina) Young Shoot Extract (1:20) 0.009 ml ♦ 4.7 mg Dried Equivalent ♦ Daily Value not established Other Ingredients: Purified water, ethanol (grain), glycerin

EACH DROP CONTAINS EQUAL PARTS OF: Robinia pseudoacacia (Black locust) Bark of Young Twigs 4X Jacaranda caroba Flower 4X Condurango Bark 4X Sabina (Savin) Twig 4X Calendula officinalis (Marigold) Flowering Tops 4X Argentum metallicum (Silver) 12X Aluminium metallicum (Aluminum) 12X Aurum metallicum (Gold) 12X Arsenicum album (Arsenic trioxide) 12X Other ingredients: Ethanol (beet), purified water

0.7 fl oz (20 ml) Liquid

NDC 62106-1198-8

EACH DROP CONTAINS EQUAL PARTS OF: Boldo Leaf 4X Senna Leaflet 4X Carduus marianus Milk thistle - Seed Marigold - Flowering Tops 4X Millefolium Yarrow Whole Plant 4X Aluminium metallicum Aluminum 12X Argentum metallicum Silver 12X

0.5 fl oz (15 ml) Liquid

Recommended Dose Adults and Children (over 12 years): From each bottle, take 5 drops three times daily or as recommended by your healthcare practitioner. See individual product packages for risk and ingredient information. Take 15 minutes before or after ingesting food or drink. To maximize results, avoid intake of coffee, tea or any products containing mint. Other medications may be taken while using Biotherapeutic Drainage™ Immune Support*; however healthcare practitioners should review the contents of each bottle to ensure applicability to individual patients. For optimal results, take Biotherapeutic Drainage™ Immune Support* twice per year, or as recommended by a healthcare practitioner. No special diet is required in order to obtain effective results with Biotherapeutic Drainage™ Immune Support*; however, to maximize results, please refer to directions as recommended by a healthcare practitioner.

Other ingredients: Ethanol (beet), purified water

0.7 fl oz (20 ml) Liquid

NDC 62106-1149-8

† Product ‘Uses’ are based on Homeopathic Materia Medica and have not been clinically tested. These ‘Uses’ have not been evaluated by the Food and Drug Administration. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

17

Notes

18

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

19

HEALING IS OUR NATURE Seroyal is a natural pharmaceutical company, dedicated for 30 years to assisting healthcare practitioners restore, rebuild and maintain patient health. For increased patient retention, compliance and efficacy, Seroyal offers the GENESTRA BRANDS, UNDA, Pharmax and Wobenzym® product lines. To help attain better patient results, the Seroyal Continuing Medical Education program is committed to providing world-class, clinically relevant information that can be immediately integrated with existing modalities for a complete, holistic approach.

To order, call:

1-888-737-6925 or email: [email protected] For more information, visit: www.seroyal.com