Imec WEARABLE HEALTH AND LIFESTYLE PLATFORMS. Imec WEARABLE HEALTH AND LIFESTYLE PLATFORMS

   DRAAGBARE SENSOREN INNOVATIEVE TECHNOLOGIE VOOR GEZONDHEIDSTOEPASSINGEN WALTER DE RAEDT [email protected] %@A0510-3G ->1C1-> G :@C1>...
Author: Doreen Ross
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DRAAGBARE SENSOREN INNOVATIEVE TECHNOLOGIE VOOR GEZONDHEIDSTOEPASSINGEN

WALTER DE RAEDT [email protected] %@A0510-3G

->1C1-> G :@C1>5 

Imec

heads et ffor br ain monitor ing

WEARABLE HEALTH AND LIFESTYLE PLATFORMS

Imec

health patch h s mar t wr is tband

heads et ffor br ain monitor ing s mar t contact lens

WEARABLE HEALTH AND LIFESTYLE PLATFORMS

hhealth patch s mar t wr is tband

s mar t textiles



  

OUR HEALTH R&D ADDRESSES 2 KEY MARKETS MEDICAL: IMPROVED (CHRONIC/ACUTE) DISEASE MANAGEMENT

PERSONAL HEALTH: PREVENTION THROUGH HEALTHIER LIFESTYLE

WEARABLE HEALTH ADDRESSES 2 KEY MARKETS MEDICAL: IMPROVED (CHRONIC/ACUTE) DISEASE MANAGEMENT

F CRD (Car diac Rhythm Dis or der ) F ) CHF (Conges tive Hear $& t Failur e)

!!% %!$% F ADD (Attention Deficit Dis or der ) !&!$% F ASD (Autis m Spectr um Dis or der ) !) F  Sleep $+ apnea )& &!!)&

(Tr aumatic br ain injur y) F TBI & !$&! F Dehydration

WEARABLE HEALTH ADDRESSES 2 KEY MARKETS PERSONAL HEALTH: PREVENTION THROUGH HEALTHIER LIFESTYLE

F F F F F

)  $& Actimetry /Activity Monitoring Energy Expenditure (EE) !!% %!$% Sleep ! monitoring %'$% Stress monitoring  $+! H& Cardiorespiratory fitness (CRF)  !))& &!! )&&  !$&!



  

NOT A (FITNESS) GADGET

REVOLUTION

OUR GOAL BRING MEDICALQUALITY DATA AND SOLUTIONS IN EVERYONE’S REACH



  

SEVERAL OF THE SYSTEMS WE CREATED ARE APPROACHING MARKET INTRODUCTION  $ ("  $ &  /$    (.! - .+ +

           

          

        

        

       

   

OUR CIRCUITS HAVE BEEN ADOPTED BY OUR CUSTOMERS

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Digital git Control

3 Readout Channels Biopotential Readout Contact Impedance Readout Current Source for Contact Impedance SAR ADC per channel

BioImpedance Readout

Current DAC SAR ADC For Bio-Imp SAR ADC (Analog IN)

6 Channel Sigma-Delta ADC (2 per a single Readout Channel)

DSP ARM Cortex M0 128kB Shared Memory

)'*(0 

Accelerators ICA/PCA MUA Accelerators

Connectivity 5 x SPI interface 2 x I2C intrface 2 x RS232 SDIO, JTAG

CONFIDENTIAL | MEGIC - MULTI-PARAMETER SINGLE CHIP SOLUTION

MEG

OUR HEALTH AND WELLNESS APPLICATION RESEARCH DOMAINS Medical Applications Funnel Str es s Management

Conges tive Hear t Failur e

Sleep Apnea

Blood Pr es s ur e

Tr aumatic Br ain Injur y

Non-convuls ive Status Epilepticus

Wellnes s Applications Funnel

Str es s Management

Vir tual Coach

HMI (motion intention)

Rehydr ation

Car dio Res pir ator y Fitnes s

  

THE ESSENTIAL ROLE OF CLINICAL PARTNERS WITH OUR CLINICAL PARTNERS WE VALIDATE SYSTEMS, ALGORITHMS THIS DRIVES APPLICATION AND SYSTEM REQUIREMENTS

THE MAIN CHALLENGES SIGNAL QUALITY

MEDI CAL GRADE SENSI NG MOTI ON ARTI FACT FI LTERI NG

FRICTIONLESS TECHNOLOGY AUTONOMY CLINICAL VALIDATION USER ADOPTION

THE RI GHT FORM FACTOR & NON-CONTACT SENSI NG

ULP DESI GN MAY NOT BE ENOUGH NEW TECHNOLOGY SOLUTI ONS TO THE RESCUE LARGE SCALE CLI NI CAL STUDI ES / TRI ALS PERSONALI ZED ALGORI THMS PERSONALI ZED FEEDBACK

FITNESS



  

FITNESS 1 3 , 5 0 0 , 0 0 0 d e a t h s e a c h y e a r f r o m c a r d i o v as c ul a r d isord e rs

9 ,4 0 0 ,0 0 0 d e a t h s d u e t o h ig h b lood p re ssu re 8 0 % of d e a t h s in low t o m id d le in c om e c ou n t rie s

the imec solution

the perfect solution

AMBULATORY SENSING NEEDS TO BE ROBUST IN DAILY-LIFE CONDITIONS

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error (kcal/min)

PERSONALIZED ALGORITHMS INCREASE ACCURACY SIGNIFICANTLY 10 9 8 7 6 5 4 3 2 1 0

6%

With 3x error reduction! personalized algorithms

Low accur acy (high er r or )

on the market today

51%

27% High accur acy (low er r or )

acc only acc-only

hr-only lying

sedentary



Differ ent par ameter s :



Hear t r ate (ECG) (-6%)



ECG combined with acceler ometer (-51%)



Per s onalized algorithms for ener gy expenditur e (-27%)

personalized

activity-specific walking

running

biking

Movie

DEMO APP Daily summaries D O Online Feature extraction and activity cclassification on the phone Online personalized energy O expenditure estimation on the phone

Filter activity allocation and FFilt energy expenditure by location en

CARDIOVASCULAR DISEASE



  

1 3 ,5 0 0 ,0 0 0 d e a t h s e a c h y e a r f rom c a rd iov a sc u la r d isord e rs

9 ,4 0 0 ,0 0 0 d e a t h s d u e t o h ig h b lood p re ssu re 1 % of a ll p e op le u lt im a t e ly d e v e lop c on g e st iv e h e a rt f a ilu re ( CHF ) [ CHF : wh e n t h e h e a rt n o lon g e r is a b le t o p u m p su f f ic ie n t b lood t o m e e t t h e n e e d s of t h e b od y ]

CONGESTIVE HEART FAILURE MONITORING:

CLINICAL PILOT USING imec WEARABLE BIO-IMPEDANCE SENSOR IS ABLE TO DETECT FLUID BUILD UP IN THE LUNGS

 Reference method: intermittent thorax Xray imaging for assessing buildup of fluids  imec wireless bioimpedance sensor tracks fluid build-up and fluid drain continuously

HEALTH PATCH

**&$-$)( + , +# %8111



  

a medical grade wearable designed for women

FRICTIONLESSTECHNOLOGY FOR WEARABLES: SMART TEXTILES

Enabling new health & sports applications with smart textiles from compression to loose fit  Comfortab le & u n ob tru sive  Reliab le in everyday situ ation s  Lon g au ton omy & rech argeab le  Wash ab le

OUR TEXTILE-INTEGRATED HEALTH PATCH



  

OUR TEXTILE-INTEGRATED HEALTH PATCH

ADDITIVE MANUFACTURING FOR LOW COST

© IMEC 2015 – imec confidential



  

LONG AND WINDING ROAD TO WEARABLE EEG

NEXT GEN COMPACT EEG SYSTEMS  System with updated chipset (EEG AFE v3.1) - Dual-mode Bluetooth module, with iPad App - ARM Cortex M4: for embedded motion artefact reduction and sample rate conversion  NEW: Digital Active - Active electrode chip is further miniaturized

Electrode v1.0

11 mm

11 .5m m

FROM PLATFORM TO PRODUCT FOR CLINICAL RESEARCH

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WRIST BAND TECHNOLOGY Parameters measured       

Skin conductance 3D-accelerometer Skin temperature Skin humidity Ambient temperature Ambient humidity Battery up to 100 hrs 34

INTEGRATION OF IMEC SENSING TECHNOLOGY IN SAMSUNG SIMBAND

Sour ce: Sams ung Str ategy andInnovationCenter http://www.s ams ung.com/us/globalinnovation/innovation_areas /

BLOOD PRESSURE MONITORING



  

BLOOD PRESSURE MONITORING

ECG PPG PAT

PEP Pr e Ej ect i onPeri odP ( EP)

A O R T IC P R E S S U R E

PTT

Pul s e Tr ans i t Time P ( TT)

L E F T V E N T R IC A L P RES S URE

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MEASURING THE PHYSIOLOGICAL RESPONSE OF STRESS respiration gets faster and shallower

pupils dilate

heartrate increases (HRV decreases)

skin conductance increases skin temperature decreases

© IMEC 2015 – imec confidentialall



  

PERSONALIZATION OF MULTISENSOR DATA IS NEEDED

P h on e cal l Meeti n g

CURRENT STATUS STRESS DETECTION IN THE LABORATORY ENVIRONMENT    % $( )(. - (

 

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RESEARCH METHODOLOGY TO ACHIEVE STRESS REDUCTION THROUGH BEHAVIOR CHANGE Stress STUDY %&"  %'$  #' &+ %&$%%

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SWEET STUDY – STRESS IN THE WORK ENVIRONMENT A large-scale, long-term trial

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RELY ON imec-AURORA, a HEALTH DATA SCIENCE PLATFORM

PERSONALIZATION FOR STRESS DETECTION AND STRESS MANAGEMENT Physiological parameters

HR/HRV Skin conductance (tonic/phasic) Respiration Electromyogram (EMG)

Contextual influencers

… Physical activity (3D acceleration) Temperature Relative humidity ...

“stress” is an individual combination of these physiological parameters



  

PRESBYOPIA

C u r r e n t p a ss i ve m u l ti f oc al c o n t a c t le n s e s h av e a p oo r a d h e r e n c e (on l y 1 5 % of s ol d c o n t a c t le n s e s ar e mu l ti f oc a l)

V a s t o p p or tu n i ti e s li e i n th e c r e a t i o n of ac t i ve vi s io n c o r r e c t i o n so lu ti on s

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1. 2 b i l l i o n p eo pl e wor l dwi de ar e e s tim ate d t o h av e p r e s byop ia, a d i s or de r af f e ctin g ev ery bod y ab o v e 45

" 0  +, 

MULTIFOCAL CONTACT LENS Target: 1 month disposable active multifocal contact lens



  

MULTIFOCAL CONTACT LENS Active bifocal contact lens

MULTIFOCAL CONTACT LENS

A SMART CONTACT LENS PLATFORM IN R&D CAN EMBED VARIOUS SENSORS Building a platform that focuses on three fundamental areas: - Autonomy - Form factor and Reliability - Eye safety and guaranteed lifetime



  

OUR GOAL BRING MEDICALQUALITY DATA AND SOLUTIONS IN EVERYONE’S REACH