DRAAGBARE SENSOREN INNOVATIEVE TECHNOLOGIE VOOR GEZONDHEIDSTOEPASSINGEN
WALTER DE RAEDT
[email protected] %@A0510-3G
->1C1-> G :@C1>5
Imec
heads et ffor br ain monitor ing
WEARABLE HEALTH AND LIFESTYLE PLATFORMS
Imec
health patch h s mar t wr is tband
heads et ffor br ain monitor ing s mar t contact lens
WEARABLE HEALTH AND LIFESTYLE PLATFORMS
hhealth patch s mar t wr is tband
s mar t textiles
OUR HEALTH R&D ADDRESSES 2 KEY MARKETS MEDICAL: IMPROVED (CHRONIC/ACUTE) DISEASE MANAGEMENT
PERSONAL HEALTH: PREVENTION THROUGH HEALTHIER LIFESTYLE
WEARABLE HEALTH ADDRESSES 2 KEY MARKETS MEDICAL: IMPROVED (CHRONIC/ACUTE) DISEASE MANAGEMENT
F CRD (Car diac Rhythm Dis or der ) F ) CHF (Conges tive Hear $& t Failur e)
!!% %!$% F ADD (Attention Deficit Dis or der ) !&!$% F ASD (Autis m Spectr um Dis or der ) !) F Sleep $+ apnea )& &!!)&
(Tr aumatic br ain injur y) F TBI & !$&! F Dehydration
WEARABLE HEALTH ADDRESSES 2 KEY MARKETS PERSONAL HEALTH: PREVENTION THROUGH HEALTHIER LIFESTYLE
F F F F F
) $& Actimetry /Activity Monitoring Energy Expenditure (EE) !!% %!$% Sleep ! monitoring %'$% Stress monitoring $+! H& Cardiorespiratory fitness (CRF) !))& &!! )&& !$&!
NOT A (FITNESS) GADGET
REVOLUTION
OUR GOAL BRING MEDICALQUALITY DATA AND SOLUTIONS IN EVERYONE’S REACH
SEVERAL OF THE SYSTEMS WE CREATED ARE APPROACHING MARKET INTRODUCTION $ (" $ & /$ (.! - .+ +
OUR CIRCUITS HAVE BEEN ADOPTED BY OUR CUSTOMERS
&&)'*($ ,#/ *+ &$'$(+0)+!$(& -,# -,/$&&
Digital git Control
3 Readout Channels Biopotential Readout Contact Impedance Readout Current Source for Contact Impedance SAR ADC per channel
BioImpedance Readout
Current DAC SAR ADC For Bio-Imp SAR ADC (Analog IN)
6 Channel Sigma-Delta ADC (2 per a single Readout Channel)
DSP ARM Cortex M0 128kB Shared Memory
)'*(0
Accelerators ICA/PCA MUA Accelerators
Connectivity 5 x SPI interface 2 x I2C intrface 2 x RS232 SDIO, JTAG
CONFIDENTIAL | MEGIC - MULTI-PARAMETER SINGLE CHIP SOLUTION
MEG
OUR HEALTH AND WELLNESS APPLICATION RESEARCH DOMAINS Medical Applications Funnel Str es s Management
Conges tive Hear t Failur e
Sleep Apnea
Blood Pr es s ur e
Tr aumatic Br ain Injur y
Non-convuls ive Status Epilepticus
Wellnes s Applications Funnel
Str es s Management
Vir tual Coach
HMI (motion intention)
Rehydr ation
Car dio Res pir ator y Fitnes s
THE ESSENTIAL ROLE OF CLINICAL PARTNERS WITH OUR CLINICAL PARTNERS WE VALIDATE SYSTEMS, ALGORITHMS THIS DRIVES APPLICATION AND SYSTEM REQUIREMENTS
THE MAIN CHALLENGES SIGNAL QUALITY
MEDI CAL GRADE SENSI NG MOTI ON ARTI FACT FI LTERI NG
FRICTIONLESS TECHNOLOGY AUTONOMY CLINICAL VALIDATION USER ADOPTION
THE RI GHT FORM FACTOR & NON-CONTACT SENSI NG
ULP DESI GN MAY NOT BE ENOUGH NEW TECHNOLOGY SOLUTI ONS TO THE RESCUE LARGE SCALE CLI NI CAL STUDI ES / TRI ALS PERSONALI ZED ALGORI THMS PERSONALI ZED FEEDBACK
FITNESS
FITNESS 1 3 , 5 0 0 , 0 0 0 d e a t h s e a c h y e a r f r o m c a r d i o v as c ul a r d isord e rs
9 ,4 0 0 ,0 0 0 d e a t h s d u e t o h ig h b lood p re ssu re 8 0 % of d e a t h s in low t o m id d le in c om e c ou n t rie s
the imec solution
the perfect solution
AMBULATORY SENSING NEEDS TO BE ROBUST IN DAILY-LIFE CONDITIONS
%5 @@5 : 3
)- 8 7 5 : 3
%@- 5 >?
%@- 5 >?
)- 8 7 5 : 3
%5 @@5 : 3
error (kcal/min)
PERSONALIZED ALGORITHMS INCREASE ACCURACY SIGNIFICANTLY 10 9 8 7 6 5 4 3 2 1 0
6%
With 3x error reduction! personalized algorithms
Low accur acy (high er r or )
on the market today
51%
27% High accur acy (low er r or )
acc only acc-only
hr-only lying
sedentary
Differ ent par ameter s :
Hear t r ate (ECG) (-6%)
ECG combined with acceler ometer (-51%)
Per s onalized algorithms for ener gy expenditur e (-27%)
personalized
activity-specific walking
running
biking
Movie
DEMO APP Daily summaries D O Online Feature extraction and activity cclassification on the phone Online personalized energy O expenditure estimation on the phone
Filter activity allocation and FFilt energy expenditure by location en
CARDIOVASCULAR DISEASE
1 3 ,5 0 0 ,0 0 0 d e a t h s e a c h y e a r f rom c a rd iov a sc u la r d isord e rs
9 ,4 0 0 ,0 0 0 d e a t h s d u e t o h ig h b lood p re ssu re 1 % of a ll p e op le u lt im a t e ly d e v e lop c on g e st iv e h e a rt f a ilu re ( CHF ) [ CHF : wh e n t h e h e a rt n o lon g e r is a b le t o p u m p su f f ic ie n t b lood t o m e e t t h e n e e d s of t h e b od y ]
CONGESTIVE HEART FAILURE MONITORING:
CLINICAL PILOT USING imec WEARABLE BIO-IMPEDANCE SENSOR IS ABLE TO DETECT FLUID BUILD UP IN THE LUNGS
Reference method: intermittent thorax Xray imaging for assessing buildup of fluids imec wireless bioimpedance sensor tracks fluid build-up and fluid drain continuously
HEALTH PATCH
**&$-$)( + , +# %8111
a medical grade wearable designed for women
FRICTIONLESSTECHNOLOGY FOR WEARABLES: SMART TEXTILES
Enabling new health & sports applications with smart textiles from compression to loose fit Comfortab le & u n ob tru sive Reliab le in everyday situ ation s Lon g au ton omy & rech argeab le Wash ab le
OUR TEXTILE-INTEGRATED HEALTH PATCH
OUR TEXTILE-INTEGRATED HEALTH PATCH
ADDITIVE MANUFACTURING FOR LOW COST
© IMEC 2015 – imec confidential
LONG AND WINDING ROAD TO WEARABLE EEG
NEXT GEN COMPACT EEG SYSTEMS System with updated chipset (EEG AFE v3.1) - Dual-mode Bluetooth module, with iPad App - ARM Cortex M4: for embedded motion artefact reduction and sample rate conversion NEW: Digital Active - Active electrode chip is further miniaturized
Electrode v1.0
11 mm
11 .5m m
FROM PLATFORM TO PRODUCT FOR CLINICAL RESEARCH
4@@;;4@98
WRIST BAND TECHNOLOGY Parameters measured
Skin conductance 3D-accelerometer Skin temperature Skin humidity Ambient temperature Ambient humidity Battery up to 100 hrs 34
INTEGRATION OF IMEC SENSING TECHNOLOGY IN SAMSUNG SIMBAND
Sour ce: Sams ung Str ategy andInnovationCenter http://www.s ams ung.com/us/globalinnovation/innovation_areas /
BLOOD PRESSURE MONITORING
BLOOD PRESSURE MONITORING
ECG PPG PAT
PEP Pr e Ej ect i onPeri odP ( EP)
A O R T IC P R E S S U R E
PTT
Pul s e Tr ans i t Time P ( TT)
L E F T V E N T R IC A L P RES S URE
9A8@5? 9A8@5 "" 9A8@55@49 -1@/ 4-.81-@5;:2;> - @45::1>-:08534@1>C>5? @.-:0
MEASURING THE PHYSIOLOGICAL RESPONSE OF STRESS respiration gets faster and shallower
pupils dilate
heartrate increases (HRV decreases)
skin conductance increases skin temperature decreases
© IMEC 2015 – imec confidentialall
PERSONALIZATION OF MULTISENSOR DATA IS NEEDED
P h on e cal l Meeti n g
CURRENT STATUS STRESS DETECTION IN THE LABORATORY ENVIRONMENT % $( )(. - (
+-+ -
$1?A8@? 8-??525/-@5;: -//A>-/D ;2 A?5:3 ?;:-85E10 /;910
9;018?
@; A?5:3 31:1>-85E10 9;018? )56?9-: 41
RESEARCH METHODOLOGY TO ACHIEVE STRESS REDUCTION THROUGH BEHAVIOR CHANGE Stress STUDY %&" %'$ #' &+ %&$%%
%&" $% )$ %%&$!' "$%!
%&" " & "$%! &$( &! % ! &*&
CLOSE THE LOOP
SWEET STUDY – STRESS IN THE WORK ENVIRONMENT A large-scale, long-term trial
< - >@5 / 5 < - : @? C1 1 7 = A 1 ? @5 ; : : - 5 >1 ? ; : 8 5 : 1
0 , )!-+$ & %1 : ? ; >?
)>5 ? @. - : 0 < - @/ 4 ? 9- >@< 4 ; : 1 - < < 8 5 / - @5 ; :
- @- - >1 A < 8 ; - 0 1 0 - : 0 ? @; >1 0 ()(0 ' )., &0 (, ! - : 0 -:-8D E 10
RELY ON imec-AURORA, a HEALTH DATA SCIENCE PLATFORM
PERSONALIZATION FOR STRESS DETECTION AND STRESS MANAGEMENT Physiological parameters
HR/HRV Skin conductance (tonic/phasic) Respiration Electromyogram (EMG)
Contextual influencers
… Physical activity (3D acceleration) Temperature Relative humidity ...
“stress” is an individual combination of these physiological parameters
PRESBYOPIA
C u r r e n t p a ss i ve m u l ti f oc al c o n t a c t le n s e s h av e a p oo r a d h e r e n c e (on l y 1 5 % of s ol d c o n t a c t le n s e s ar e mu l ti f oc a l)
V a s t o p p or tu n i ti e s li e i n th e c r e a t i o n of ac t i ve vi s io n c o r r e c t i o n so lu ti on s
)- &*)*.& -$)(
1. 2 b i l l i o n p eo pl e wor l dwi de ar e e s tim ate d t o h av e p r e s byop ia, a d i s or de r af f e ctin g ev ery bod y ab o v e 45
" 0 +,
MULTIFOCAL CONTACT LENS Target: 1 month disposable active multifocal contact lens
MULTIFOCAL CONTACT LENS Active bifocal contact lens
MULTIFOCAL CONTACT LENS
A SMART CONTACT LENS PLATFORM IN R&D CAN EMBED VARIOUS SENSORS Building a platform that focuses on three fundamental areas: - Autonomy - Form factor and Reliability - Eye safety and guaranteed lifetime
OUR GOAL BRING MEDICALQUALITY DATA AND SOLUTIONS IN EVERYONE’S REACH