CIBTech Journal of Pharmaceutical Sciences ISSN: 2319–3891 (Online) An Online International Journal Available at http://www.cibtech.org/cjps.htm 2012 Vol. 1 (2-3) Jul.-Sept. & Oct.-Dec., pp.1-6/Suprapta et al.

Research Article

HYPOGLYCEMIC AND ANTIOXIDANT ACTIVITIES OF BALINESE PURPLE SWEET POTATO (IPOMOEA BATATAS L) IN INDUCEDDIABETIC RATS I Made Jawi1, I Wayan Putu Sutirta-Yasa2, *Dewa Ngurah Suprapta3 and Agung Nova Mahendra1 1 Department of Pharmacology and 2Department of Clinical Pathology Udayana University Denpasar Bali Indonesia 3 Department of Agriculture, Udayana University Denpasar Bali Indonesia *Author for Correpondence ABSTRACT Anthocyanins from plants are potent antioxidants, which may have beneficial effects against oxidative stress-related diseases, such as diabetes mellitus. Balinese purple sweet potato (Ipomoea batatas L.) is an anthocyanin-rich food source. This study was aimed to investigate the effect of water extract of Balinese purple sweet potato on blood glucose level and oxidative stress in diabetic rats. Subject of this study were 20 male adult rats divided into 2 groups with randomized pre-test and post-test control group design. Blood glucose, malondialdehyde (MDA), and total antioxidant levels of all rats were measured before and after treatment. After obtaining pre-test data, all of the groups were treated with streptozotocin (STZ) at 40 mg/kg body weight intraperitoneally to induce diabetic condition. Three days later, the treatment group of rats was treated with 3 ml/day of water extract of purple sweet potato for 60 days. The control group of rats was given 3 ml of water per day. Blood glucose, MDA, and total antioxidant levels were measured to obtain post-test data at day 30 and 60. The results showed that in control group, there was a significant (p