■ Hokkaido Bio Technology Industrial Cluster Forum

Greeting

Hokkaido Biotechnology Industrial Cluster Forum 

President

Hokkaido Bio Technology Industrial Cluster Forum ■

Kenichi Kosuna

The Hokkaido Biotechnology Industrial Cluster Forum was established in July 2002, aimed at encouraging partnerships among the biotechnology industries of Hokkaido and expanding the market for local products, based on the Industry Cluster Project by the Hokkaido Bureau of Economy, Trade and Industry. Our organization was initially supported by 55 Hokkaido companies and a group of partnership businesses consisting of 20 partners outside Hokkaido . We are promoting more extensive networks now, comprised of 123 participating companies and 68 partners outside of Hokkaido as of January 2013. By organizing a steering committee to operate the project smoothly, and posting cluster managers for comprehensive management of the project, the forum has been making efforts for enhancement of networks and expansion of business. These efforts contribute to the growing expansion of cooperation networks with new business partners and are starting to steadily show successful results. The Hokkaido region is designated as a bio-industry cluster promoting area in the Biotechnology Strategy Guidelines. It is also ranked second in the number of bioventure businesses by prefecture based on the survey results by the JBA, which means that companies are concentrating in this region. This forum will be dedicated to forming a more solid bio-industry cluster in collaboration with local organizations toward further development of bio-industry in Hokkaido. We would like to ask all parties concerned to provide further support and cooperation.

What is the Hokkaido Biotechnology Industrial Cluster Forum?

Members of the    Steering Committee President

 Kenichi Kosuna

President

Amino Up Chemical Co., Ltd.

 Tsutomu Inoue Vice-president

Hokkaido System Science Co., Ltd.

 Satoru Kamada

President

Hokudo Co., Ltd.

 Koichi Takada

President

GeneticLab Co., Ltd.

 Hiroki Sado

President

Hokkaido Bio-industry Corporation

  Hiroshi Ishimoto President

Hokkaido Mitsui Chemicals, Inc.

 Katsuyoshi Kumagai

Director of Hokkaido Factory

COSMO FOODS Co., Ltd.

To foster and develop bio-industry in Hokkaido, the forum promotes the formation of a bio-company network in Hokkaido and cooperates with a group of businesses outside the prefecture that are potential business partners for local bio-businesses. The group is called the partners outside Hokkaido and includes trading firms, venture companies, financial institutions, and manufacturers. The forum is striving to expand the market for bioproducts of Hokkaido by actively promoting national biobusiness interchanges (business matching). In addition, the forum aims to seek further results by linking with multilayered networks, including networks of universities and research institutes, independent activities by businesses etc., and regional/sectoral organizations. These activities have already produced some results, such as advanced accumulation of businesses and improved name recognition in Hokkaido s bio-industry, which shows sustainable growth by increasing sales and number of employees.

Organization Scheme of the Hokkaido Biotechnology Industrial Cluster Forum

Cluster Managers

ent

Presid Mr. Hisato Doi

,

Japan s bio-industry cluster promoting areas and the number of bio-venture businesses Number of bio-venture businesses by prefecture (JBA's survey as of October 2012) ■Number of businesses per million people  Tokyo (11.0)  Kyoto (10.2)  Okinawa (7.8)  Kanagawa (7.2)  Shiga (7.0)  Ibaraki (6.0)  Hokkaido (5.4)

ariat ion) Secret EC Foundat T S (NOA

mittee

g Com

Steerin

President Human Capital Management, Inc.

■Number of  businesses  Tokyo (145)  Kanagawa (66)  Osaka (45)  Hokkaido (30)  Chiba (28)

The Hokkaido Bureau of Economy, Trade and Industry launched the Hokkaido Super Cluster Promotion Project in April 2001, aimed at promoting the formation of an information industry cluster and bio-industry cluster in Hokkaido, and has been making active efforts for realization. In response to these efforts, the Hokkaido Biotechnology Industrial Cluster Forum was established in July 2002, and full-scale activities for formation and development of clusters started. For fiscal 2011, the bureau will formulate the Hokkaido BioInnovation Strategy as a ten-year strategy for growth, focusing on the key phrase health and new foods, the endowments of biotechnology. The bureau will encourage innovations in food, agriculture and health, and it will help to add value to related industries by using Hokkaido's advantages of biotechnology for food resources and seeds in the medical care and pharmaceutical sector.

Hokkaido Bio-cluster

（Hokkaido Bio-industry Development Project

）

embly al Ass ing/ r e n e G eet ns ular M （ Reg ation Sessio t n e Pres f the pany o gy m o c er lo echno Memb o Biot Forum id a k k r Ho ste rial Clu Indust

）

President Management

rting Suppo tion etc. a iz n orga

10∼19 20∼29 30∼

Kanto Bio-cluster

（Capital Sphere Bio-Genome Venture Network

Support/subsidy

Presentation NOASTEC

1∼4 5∼9

Leadership in development of project

f reau o ido Bu Hokka y, m Econo d Industry n a e d a Tr

Hokkaido Bureau of Economy, Trade&Industry

Hokkaido Bio Technology Industrial Cluster

）

Multilateral support including financial marketing Kinki Bio-cluster

（Kansai Bio-cluster Project

Support ）

Collaboration

■ Hokkaido Bio Technology Industrial Cluster Forum

Main Activities Excavation of Bio-seeds , from the information of Companies, Universities, etc. We investigate products and key technologies of member companies and publicize the collected information to promote business cooperation and academia-industry joint research. We also collect research information from local universities to identify effective seeds for the promotion of Hokkaido,s bio-industry, and promote the transfer of technology, including research achievements of universities or other institutes.

Hokkaido Bio Technology Industrial Cluster Forum ■

of the Hokkaido Biotechnology Industrial Cluster Forum Company Presentation Sessions

Promotion of Cooperation We actively promote cooperation and interaction with bio-industry concentrated areas in Japan in order to expand business opportunities for biobusiness companies in Hokkaido and strengthen , the foundation of Hokkaido s bio-industry and expand their business focusing on the future.

Presentation sessions aim to promote new cooperation by introducing products and techniques of companies participating in the forum and information on partners outside Hokkaido.

Cluster Forum and Business Exchanges between Tokachi-related companies (Aug. 2012)

Company presentation session (Jun. 2011)

Business exchanges between Hokkaido and Okinawa (Sep. 2012)

Hokkaido Biotechnology Industrial Cluster Forum Participating Company List （Japanese ）

Business Exchanges and Business Meetings of "Food & Health Clusters" between Hokkaido & France (Jan. and Oct. 2011)

Cluster Forum and Business Exchanges between Hakodate-related companies (Oct. 2012)

Hokkaido Biotechnology Industrial Cluster Forum Participating Company List （English ）

Bio-Business Matching in Kansai (Osaka) (Feb. 2012)

Business Matching of "health foods and cosmetics" in Sapporo (Nov. 2012)

Company presentation session (July. 2012)

■ Hokkaido Bio Technology Industrial Cluster Forum

Hokkaido Bio Technology Industrial Cluster Forum ■

Support for Market Development

Provision of Information

We participate in exhibitions etc. held inside and outside the country in order to develop new markets and seek new businesses.

Participation in exhibitions in the country

SAPPORO Health & Beauty FAIR 2012

（H24.10

We hold symposiums on themes necessary for the development of new businesses in the biotechnology field in Hokkaido, such as the current status of cutting-edge biotechnological studies. We also provide support for promoting the development of new businesses, the creation of university-launched venture businesses and the holding of meetings. In addition, we promote information disclosure through our website etc. to form a wide-area bio-industrial cluster.

）

Discussion on the uses of medicinal plants and the development of related industries in Hokkaido (Oct. 2011- Feb. 2012) Fund-raising seminars (Oct. 2011- Jan. 2012)

BIO JAPAN 2012

（H24.10

）

Health Ingredients Japan 2012, Safety and Technology Japan 2012 (Oct. 2012)

Participation in exhibitions outside the country

BIO EUROPE SPRING 2011

（H23.3 ）

Health and Wellness Industry Symposium (Oct. 2011)

Matching in Hong Kong (Nov. 2012)

Health Science Seminar (Feb. 2011)

Seeds Exhibition (Sep. 2012)

Exchanges between food-related companies (Jan. 2012)

■ Hokkaido Bio Technology Industrial Cluster Forum

Hokkaido Bio Technology Industrial Cluster Forum ■

■ Characteristics of Hokkaido Bio-industrial Cluster

■ Multilayered Network Environment (216 companies)

● Research cost for next generation   post-genomic research, company   network   (167 researchers, 49 companies)

sector is as follows: Functional foods and cosmetics account for the largest percentage (47%), followed by research support (14%), medical care and medical drug (14%) and agricultural biotechnology (9%).

Cooperation

Also, the total prospective sales and the number of employees in 2011 are approximately 50.8 billion yen (a 0.0%

Support Network such as administrative institutions

year-on-year increase) and 1,579 people (a 1.5% year-on-year increase), respectively.

Others 23 companies (16%) Agricultural biotechnology 10 companies (9%) Research Support 17 companies (14%)

60,000

35,000 30,000

Development of reagents and experimental animals for research, contract test for safety and pharmacological effect, research development and analysis service etc. of gene and protein, etc.

20,000

Development of biomedicine, pharmaceutical or medical material and research development of medical diagnosis technology, etc

Development of seed and seedling, plant growth and activation agent, development of agriculture, livestock husbandry and green material utilizing microorganisms, etc.

Development of environmental purification and biomass equipment utilizing microorganisms, development of bio-related research devices and or equipment, Bioinformatics, etc.

15,000 10,000 5,000 0

10,544

584 19,161

12,530

23,965

871

47,069 49,900

130

907

110 100

62

90 80

64

70

75

77

74

73

60 40 30 14 3

18 6

24 10

18

26

32

32

35

37

37

37

1400 1300

1000 900

34,218

800 700

24,599 25,629

500 400

16,599

300 200

100 0

34

FY1999 FY2000 FY2001 FY2002 FY2003 FY2004 FY2005 FY2006 FY2007 FY2008 FY2009 FY2010 Other

Northern Advancement Center for Science & Technology Cooperation

Sectoral and Regional networks of cluster participating companies (91 companies)

[Main organizations] ● Tokachi Promotion Institution   (Agricultural biotechnology sector:  30 companies, etc.) ● Hakodate Regional Industry Promotion  Organization (Marine biotechnology  sector: 30 companies, etc.) ● Hokkaido Bio-Industrial Promotion  Association (Food and agricultural  biotechnology sector: 31 companies)

Business Supporter Network including trading company, finance and VC, etc.

■ Research Seeds and Incubation Facilities etc. Concentration of research and incubation bases in northern areas of Hokkaido University campus

National Institute of Advanced Industrial Science and Technology Hokkaido Center

0.1 billion yen 41

27

17

19

23

25

27

29

37

39

43

32

20

10

0

(109 companies)

● Partners of Bio-industrial Cluster   outside of Hokkaido (68 companies) ● Industrial cluster support financial   meeting in Hokkaido region (33 companies) ● Hokkaido Bio-Venture and   Mentor Network (8 people)

Hokkaido University next-generation post-genome research building

5

Biotechnology

● Network with Kinki region  (6 bio-related institutions   in Kinki region)

Number of employees

30

15

(6 institutions)

[Promotion Organization]

600

35

20

36

50

1500

Broad Intercommunion Network

Hokkaido Bio-industrial Cluster Forum

(123 bio-related companies in Hokkaido participated in the forum)

Drawing up strategies, support for applying various policies based on the strategy.

1200

FY1999 FY2000 FY2001 FY2002 FY2003 FY2004 FY2005 FY2006 FY2007 FY2008 FY2009 FY2010 FY2011

25

50

70

1600

1100

40

120

50,811 50,834

42,562

Total sales

45

0

457

510

848

1,424

Person

1,527 1,556 1,579

(105 companies, etc.)

● TACTICS (39 companies) ● Hokkaido Association for   Bio-Business (32 companies) ● Hokkaido Bio-Venture Network   (Dosanko-Bio, etc:   34 university-launched ventures)

Cooperation

Cooperation

Hokkaido Bureau of Economy, Trade and Industry

Self-activity Network by companies, etc.

◆ Changes in research and development investment  （Hokkaido Bio Report 2012 ）

（Hokkaido Bureau of Economy,   Trade and Industry ）

10

746

25,000

◆ Number of university-launched ventures

20

1,221

40,000

Medical care/ Medical drug 16 companies (14%)

Research Support

Others

1,324

45,000

Development of functional foods, cosmetics and raw materials, etc. utilizing agricultural and fishery resources and microorganism, etc.

Agricultural biotechnology

Million yen

50,000

Functional food/ Cosmetics Medical care/ Medical drug

(34 institutions)

● Bio-industrial administrative   collaboration meeting  (C7 Hokkaido) ● Hokkaido intellectual property   strategy headquarters   (25 institutions)

◆ Changes in total sales   and the number of employees  （Hokkaido Bio Report 2012 ）

Functional food/ Cosmetics 55 companies (47 ％)

（21 universities, etc.)

● Hokkaido University ● FUTURE UNIVERSITY-HAKODATE ● Obihiro University of Agriculture   and Veterinary Medicine ● Sapporo Medical University ● Advanced Industrial Science   And Technology Hokkaido ,etc.

Research and Technology Development Promotion Network

The number of companies in the Hokkaido Bio-industrial Cluster continues to grow each year. The breakdown by

◆ Percentage distribution by sector   (Hokkaido Bio Report 2012)

Network with Collaborative Universities and Research Institutions

FY1999 FY2000 FY2001 FY2002 FY2003 FY2004 FY2005 FY2006 FY2007 FY2008 FY2009 FY2010 FY2011 Research and development investment

〈Biotechnology Center

〉

〈Isolated genetically-modified plant factory 〉

National Agricultural Research Center for Hokkaido Region Cold Region Biofunction Development Center

Hokkaido Industry-Academic-Government Collaboration Center Colabo Hokkaido

Hokudai Business Spring

Distribution of Hokkaido Bio-industry Cluster (Note) Only participating companies of Hokkaido Bio-industrial Cluster Forum Marukyo Bio Foods Co.,Ltd.

ASAHI KOGYOSHA Co.,Ltd. ABYSSAL JAPAN Inc. Ama Public Corporation. Amino Up Chemical Co.,Ltd. EVEC,Inc. ITOCHU TECHNO-Solutions Corporation IMUNO-SCIENCE Immunobion Co.,Ltd. Ingenex. Biotechnologies Inc. A-HITBio Inc. EXAM Co.,Ltd. ECONIXE Co.,Ltd. NBHL Co.,Ltd.

Institute of Applied Medicine, Inc. Ogawa Advantec Machinery Inc. Safety Research Institute for Chemical Compounds Co.,Ltd. Katsuri, Inc. Kitaguni Life Co., Ltd. Biodynamic Plant Institute Co.,Ltd. Clinical Support Corporation. Chromosome Science Labo Inc. KELP Industries, Inc. GENMAIKOSO Co., Ltd. CORNES & COMPANY LIMITED CORNES BIOGAS Goryo Chemical, Inc. Immuno-Biological Laboratories Co.,Ltd. Sapporo Bio Factory Co.,Ltd. SAPPORO CLINICAL LABORATORY Inc. SUPPLE ART Co.,Ltd. C's TEC Inc. C's Lab Co.,Ltd. GP Biosciences Ltd. Shouyaku kenkyusho Inc. GENE TECHNO SCIENCE Co.,Ltd.

GeneticLab Co.,Ltd. GEL-Design Inc. SETEC. Co.,Ltd. Serotec Co.,Ltd. Central Systems Co., Ltd. Nature and Chemical Research Institute Co., Ltd. Nippon Meat Packers Inc. R&D center Newton Graphics,Inc. Northbio Laboratories,Inc. HAYASAKA RIKOH Co.,Ltd. Bioimmulance Co.,Ltd. Bio Lafer,Inc. Human Capital Management Inc. Hrein Energy,Inc. Primary Cell Co.,Ltd. Plus Chemical Industry Co.,Ltd. Progresso Co.,Ltd. Hairmertec Co., Ltd. Hokudo Co.,Ltd. Hokkaido Environment Bio-sector Ltd. Hokkaido Green Kousan Co.,Ltd. Hokkaido Coca-Cola Bottling Co.,Ltd. Hokkaido System Science Co.,Ltd. Hokkaido Bio-Industry Corporation Hokkaido Venture Capital, Inc. Hokkaido Reishi Co., Ltd. HOKKAIDO WAKO PURE CHEMICAL INDUSTRIES, Ltd. Mutoh Co.,Ltd. Medical Image Lab Inc. SNOW BRAND SEED Co.,Ltd. Milk Science Sapporo Research Laboratory, Megmilk Snow Brand Co., Ltd. Leaps.Inc. Research of Microbes Co.,Ltd.

Sigma-Aldrich Japan,K.K. Life Seisence Division Frontier Institute Co.,Ltd. Hokkaido Sugar Co.,Ltd. Three-B Co.,Ltd.

MOCHIGOME NO SATO FUUREN TOKUSANKAN Co.,Ltd. Hokkaido Plant,TOKIWA CHEMICAL INDUSTRIES Co., Ltd.

Hokkaido Mitsui Chemicals,Inc.

KINJIRUSHI WASABI Co.,Ltd. Tokyo Nodai Bioindustry Co.,Ltd.

Ozone Technology Laboratory Inc. Densei Communication Inc. RYOKUSAN Co.,Ltd. Ihara&Company

Ohtaka Enzyme Co.,Ltd. KYOSEI HOKKAIDO WINE Co.,Ltd.

Immuno-Biological Laboratories Co.,Ltd.

Sinnihonkoso,KK Takasagoshuzo,Inc. Pekalt Chemical Inc.

Noevir Co.,Ltd. Harunire Bio Laboratory Co.,Ltd. Fujibion Giken Inc.

Fujiisuisan Co.,Ltd. Mori Sangyo Co.,Ltd Okamoto Plant Breeding Biomatech Japan,Inc.

RAISIN CORPORATION HOKKAIDO SODA Co.,Ltd.

Hokkaido Lime Co.,Ltd.

North Civil Engineering Consultants Co., Ltd. BIO CREATE Co.,Ltd.

COSMO FOODS Co.,Ltd. SHIZUNAI EISEISHA Co.,Ltd. NPDI Co.,Ltd.

ACT Co.,Ltd. Nippon Beet Sugar MFG. Co.,Ltd. NYUTEX Co.,Ltd. Huens Co.,Ltd. MARUKATSU Co.,Ltd. Yamachu Co.,Ltd.

Companies outside of Hokkaido

Japan Food Research Laboratories Nippon Shinyaku Co.,Ltd. BIPHA CORPORATION Hokkaido Junbayu Honpo Inc. Hokusan Co., Ltd. Yotsuba Milk Products Co.,Ltd.

Eniwa Research Business Park Co.,Ltd. Plant Ecochemicals Research Center New Drug Development Research Center, Inc. Naturalcare Corporation Nissei Bio Co.,Ltd.

Hitachi High-Tech Fielding Corporation HABA Laboratories Inc. Mayekawa MFG. Co., Ltd.

'13.01

Hokkaido Bio Technology Industrial Cluster Forum Member Companies （123companies） company name

company name

ABYSSAL JAPAN Inc.

Ingenex. Biotechnologies Inc.

ACT Co.,Ltd.

Institute of Applied Medicine, Inc.

A-HITBio Inc.

ITOCHU TECHNO-Solutions Corporation

Ama Public Corporation.

Japan Food Research Laboratories

Amino Up Chemical Co.,Ltd.

Katsuri, Inc.

ASAHI KOGYOSHA Co.,Ltd.

KELP Industries, Inc.

BIO CREATE Co.,Ltd.

KINJIRUSHI WASABI Co.,Ltd.

Biodynamic Plant Institute Co., Ltd.

Kitaguni Life Co., Ltd.

Bio Lafer,Inc.

KYOSEI PHARMACEUTICAL Co.,Ltd.

Bioimmulance Co.,Ltd.

Leaps.Inc.

Biomatech Japan,Inc.

MARUKATSU Co.,Ltd.

BIPHA CORPORATION

Marukyo Bio Foods Co.,Ltd.

Central Systems Co., Ltd.

Mayekawa MFG. Co., Ltd.

Chromosome Science Labo Inc.

Medical Image Lab Inc.

Clinical Support Corporation.

Milk Science Sapporo Research Laboratory, Megmilk Snow Brand Co., Ltd.

CORNES & COMPANY LIMITED CORNES BIOGAS

MOCHIGOME NO SATO FUUREN TOKUSANKAN Co.,Ltd.

COSMO FOODS Co.,Ltd.

Mori Sangyo Co.,Ltd.

C's Lab Co.,Ltd.

Mutoh Co.,Ltd.

C's TEC Inc.

Naturalcare corporation

Densei Communication Inc.

Nature and Chemical Research Institute Co., Ltd.

ECONIXE Co.,Ltd.

NBHL Co.,Ltd.

Eniwa Research Business Park Co.,Ltd.

New Drug Development Research Center, Inc.

EVEC,Inc.

Newton Graphics, Inc.

EXAM Co.,Ltd.

Nippon Beet Sugar MFG. Co.,Ltd.

Frontier Institute Co.,Ltd.

Nippon Meat Packers Inc. R&D center

Fujibion Giken Inc.

Nippon Shinyaku Co.,Ltd.

Fujiisuisan Co.,Ltd.

Nissei Bio Co.,Ltd.

GEL-Design Inc.

Noevir Co.,Ltd.

GeneticLab Co.,Ltd.

Northbio Laboratories,Inc.

GENMAIKOSO Co.,Ltd.

North Civil Engineering Consultants Co., Ltd.

GENE TECHNO SCIENSE Co.,Ltd.

NPDI Co.,Ltd.

GP Biosciences Ltd.

NYUTEX Co.,Ltd.

Goryo Chemical, Inc.

Ogawa Advantec Machinery Inc.

HABA Laboratories Inc.

Ohtaka Enzyme Co.,Ltd.

Harunire Bio Laboratory Co.,Ltd.

Okamoto Plant Breeding

HAYASAKA RIKOH Co.,Ltd.

Ozone Technology Laboratory Inc.

Hairmertec Co., Ltd.

Pekalt Chemical Inc.

Hitachi High-Tech Fielding Corporation

Plant Ecochemicals Research Center

Hokkaido Bio-Industry Corporation

Plus Chemical Industry Co.,Ltd.

Hokkaido Coca-Cola Bottling Co.,Ltd.

Primary Cell Co.,Ltd.

Hokkaido Environment Bio-sector Ltd.

Progresso Co.,Ltd.

Hokkaido Green Kousan Co.,Ltd.

RAISIN CORPORATION

Hokkaido Junbayu Honpo Inc.

Research Of Microbes Co.,Ltd.

Hokkaido Lime Co.,Ltd.

RYOKUSAN Co.,Ltd.

Hokkaido Mitsui Chemicals,Inc.

Safety Research Institute for Chemical Compounds Co.,Ltd.

Hokkaido Plant,TOKIWA CHEMICAL INDUSTRIES Co.,Ltd.

Sapporo Bio Factory Co.,Ltd.

Hokkaido Reishi Co., Ltd.

SAPPORO CLINICAL LABORATORY Inc.

HOKKAIDO SODA Co.,Ltd.

Sapporo Immuno Diagnostic Laboratory

Hokkaido Sugar Co.,Ltd.

Serotec Co.,Ltd.

Hokkaido System Science Co.,Ltd.

SETEC. Co.,Ltd.

Hokkaido Venture Capital, Inc.

SHIZUNAI EISEISHA Co.,Ltd.

HOKKAIDO WAKO PURE CHEMICAL INDUSTRIES, Ltd.

Shouyaku kenkyusho Inc.

HOKKAIDO WINE Co.,Ltd.

Sigma-Aldrich Japan,K.K. Life Science Division

Hokudo Co.,Ltd.

Sinnihonkoso,KK

Hokusan Co., Ltd.

SNOW BRAND SEED Co.,Ltd.

Hrein Energy,Inc.

SUPPLE ART Co.,Ltd.

Huens Co.,Ltd.

Takasagoshuzo,Inc.

Human Capital Management Inc.

Three-B Co.,Ltd.

Ihara&Company

Tokyo Nodai Bioindustry Co.,Ltd.

Immuno-Biological Laboratories Co.,Ltd.

Yamachu Co.,Ltd.

Immunobion Co.,Ltd.

Yotsuba Milk Products Co.,Ltd.

IMUNO-SCIENCE '13.01